GREMLIN Database
PREA - NAD-dependent dihydropyrimidine dehydrogenase subunit PreA
UniProt: P25889 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11289
Length: 411 (377)
Sequences: 928 (545)
Seq/√Len: 28.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
164_K195_D7.1701.00
164_K171_M5.8941.00
265_W299_G4.9131.00
96_K129_D4.7491.00
356_D359_H3.9771.00
304_L315_M3.4811.00
313_Q316_V3.4781.00
311_S314_E3.4741.00
124_Q168_T3.2311.00
172_L196_G3.1581.00
190_K254_F3.1431.00
309_F315_M3.1351.00
356_D360_Q2.9441.00
257_S278_T2.8491.00
13_V130_M2.7111.00
22_S282_T2.7091.00
187_L191_R2.6841.00
272_L316_V2.6550.99
238_A271_F2.6310.99
7_S14_K2.5930.99
378_C381_C2.5790.99
356_D362_M2.5380.99
157_E191_R2.5320.99
157_E161_R2.5190.99
124_Q169_L2.4360.99
262_I279_L2.3790.99
290_Y295_D2.3040.99
210_D213_Q2.2840.98
154_E158_K2.2650.98
235_K270_E2.2370.98
16_P102_K2.2330.98
356_D361_A2.2150.98
9_T14_K2.1660.98
255_P277_A2.1600.98
16_P101_D2.1460.98
310_D314_E2.1150.97
359_H362_M2.0890.97
344_C381_C1.9570.96
20_C278_T1.9450.96
378_C389_P1.9440.96
339_I373_C1.8900.95
160_C173_A1.8650.95
15_F278_T1.8450.94
37_Y102_K1.8290.94
239_L271_F1.8220.94
11_C196_G1.8110.94
200_I238_A1.8050.94
344_C378_C1.7390.92
292_I295_D1.7370.92
268_A279_L1.7050.91
262_I271_F1.6940.91
97_E101_D1.6930.91
118_E122_L1.6840.91
13_V103_V1.6710.91
357_G360_Q1.6520.90
21_L41_W1.6400.90
221_N330_D1.6400.90
212_N307_Q1.6100.89
358_G381_C1.6060.89
10_F172_L1.6060.89
183_C248_H1.6060.89
145_M148_D1.5960.88
290_Y293_V1.5880.88
4_K301_S1.5710.88
61_F283_T1.5610.87
138_P228_G1.5540.87
73_G76_N1.5430.87
157_E192_G1.5330.86
281_V296_M1.5320.86
92_L104_L1.5100.85
25_P286_M1.5050.85
293_V297_A1.5040.85
378_C382_L1.5010.85
73_G77_M1.5010.85
359_H379_V1.5000.85
70_G74_F1.4990.85
358_G361_A1.4970.85
288_Y292_I1.4750.84
272_L315_M1.4720.84
358_G378_C1.4620.84
348_G361_A1.4620.84
62_D207_T1.4590.83
356_D379_V1.4400.83
20_C43_G1.4270.82
73_G78_E1.4250.82
198_A259_I1.4090.81
268_A272_L1.3940.80
293_V299_G1.3860.80
293_V296_M1.3830.80
199_A245_M1.3770.80
373_C378_C1.3730.79
346_G377_K1.3710.79
272_L279_L1.3700.79
72_I75_K1.3670.79
312_L315_M1.3480.78
288_Y295_D1.3450.78
381_C389_P1.3410.78
34_A98_D1.3400.78
384_C388_C1.3330.77
15_F20_C1.3320.77
76_N81_A1.3280.77
269_A300_L1.3190.77
74_F77_M1.3180.77
284_G292_I1.3140.76
357_G362_M1.3040.76
380_G383_L1.3040.76
117_E165_R1.2990.75
19_F297_A1.2990.75
235_K267_D1.2740.74
373_C376_E1.2710.74
35_K38_D1.2670.74
318_L321_N1.2670.74
344_C358_G1.2660.74
346_G349_R1.2600.73
106_A128_A1.2460.72
289_G292_I1.2440.72
4_K305_A1.2410.72
268_A296_M1.2380.72
386_H392_C1.2350.72
358_G362_M1.2290.71
300_L306_D1.2280.71
303_Y309_F1.2170.71
268_A300_L1.2130.70
246_R320_N1.2120.70
246_R252_R1.1960.69
170_P317_G1.1910.69
363_E372_H1.1790.68
114_Q118_E1.1740.68
38_D99_Y1.1700.67
131_I169_L1.1680.67
18_P40_G1.1630.67
203_V237_I1.1620.67
13_V272_L1.1550.66
242_I256_I1.1440.66
27_G47_K1.1390.65
105_I278_T1.1360.65
136_S228_G1.1350.65
341_L391_G1.1290.65
115_Q119_L1.1280.65
56_E60_R1.1270.64
120_A167_S1.1240.64
212_N306_D1.1180.64
187_L248_H1.1130.63
240_R244_Q1.1090.63
312_L318_L1.1090.63
389_P393_I1.1060.63
201_N230_S1.1030.63
118_E121_R1.1020.63
291_R295_D1.0970.62
200_I259_I1.0870.62
76_N79_Q1.0850.61
281_V284_G1.0720.61
33_C46_F1.0600.60
177_P201_N1.0530.59
101_D104_L1.0500.59
22_S60_R1.0500.59
373_C380_G1.0440.58
74_F78_E1.0390.58
347_C350_C1.0250.57
113_E158_K1.0190.57
117_E121_R1.0180.56
317_G320_N1.0150.56
353_S382_L1.0140.56
249_P254_F1.0120.56
258_G268_A1.0080.56
90_A93_R1.0070.56
336_Y375_T1.0030.55
60_R228_G1.0020.55
228_G231_G1.0020.55
41_W293_V1.0020.55
348_G381_C1.0000.55
243_Q320_N0.9970.55
17_N297_A0.9970.55
129_D132_E0.9960.55
379_V383_L0.9910.54
269_A273_L0.9900.54
110_G119_L0.9880.54
44_V159_Y0.9850.54
268_A282_T0.9800.54
211_L269_A0.9760.53
48_T200_I0.9760.53
332_S335_V0.9730.53
272_L312_L0.9730.53
356_D381_C0.9680.53
258_G262_I0.9670.53
26_V285_I0.9650.52
277_A316_V0.9640.52
75_K79_Q0.9640.52
359_H380_G0.9620.52
305_A308_G0.9620.52
16_P42_G0.9620.52
373_C381_C0.9600.52
159_Y162_A0.9560.52
101_D313_Q0.9550.52
79_Q82_E0.9550.52
330_D333_Y0.9540.52
269_A315_M0.9520.51
349_R361_A0.9510.51
346_G386_H0.9510.51
298_S301_S0.9500.51
72_I76_N0.9460.51
377_K381_C0.9460.51
6_L267_D0.9370.50
303_Y315_M0.9310.50
373_C389_P0.9300.50
359_H381_C0.9280.50
30_Y94_R0.9230.49
33_C159_Y0.9230.49
15_F103_V0.9210.49
357_G379_V0.9190.49
28_N42_G0.9150.49
385_G390_V0.9070.48
209_I213_Q0.9060.48
334_I343_K0.9050.48
361_A381_C0.9040.48
23_S47_K0.9040.48
340_N343_K0.9030.48
160_C189_A0.9010.48
61_F75_K0.9000.47
202_T228_G0.8990.47
344_C380_G0.8960.47
344_C348_G0.8950.47
349_R381_C0.8950.47
370_T391_G0.8930.47
120_A131_I0.8880.47
95_L104_L0.8860.46
15_F130_M0.8850.46
34_A38_D0.8830.46
353_S379_V0.8800.46
358_G389_P0.8800.46
341_L376_E0.8800.46
120_A163_V0.8790.46
331_R337_P0.8790.46
78_E81_A0.8780.46
48_T109_M0.8780.46
77_M227_S0.8740.45
351_Y360_Q0.8690.45
353_S387_V0.8650.45
249_P252_R0.8630.45
235_K262_I0.8630.45
10_F278_T0.8620.45
144_A147_S0.8590.44
336_Y339_I0.8580.44
345_V390_V0.8570.44
357_G375_T0.8570.44
117_E120_A0.8550.44
308_G311_S0.8550.44
90_A94_R0.8520.44
348_G358_G0.8500.44
270_E315_M0.8470.43
346_G361_A0.8470.43
160_C194_A0.8460.43
372_H377_K0.8450.43
353_S383_L0.8440.43
78_E150_G0.8420.43
344_C389_P0.8390.43
311_S318_L0.8370.43
78_E82_E0.8330.42
209_I274_L0.8320.42
343_K392_C0.8310.42
23_S137_C0.8300.42
120_A169_L0.8290.42
356_D380_G0.8270.42
279_L315_M0.8230.42
335_V338_R0.8190.41
28_N32_M0.8160.41
356_D382_L0.8160.41
379_V382_L0.8140.41
71_F74_F0.8130.41
244_Q247_T0.8130.41
54_A106_A0.8120.41
287_Q349_R0.8120.41
281_V293_V0.8060.40
52_F55_N0.8050.40
58_S262_I0.7990.40
381_C393_I0.7980.40
211_L270_E0.7940.39
377_K392_C0.7910.39
378_C383_L0.7880.39
71_F76_N0.7880.39
363_E370_T0.7850.39
223_K324_V0.7830.39
59_P231_G0.7810.39
363_E376_E0.7800.38
77_M81_A0.7800.38
335_V352_I0.7800.38
363_E391_G0.7790.38
202_T230_S0.7790.38
376_E383_L0.7790.38
84_P87_E0.7770.38
183_C243_Q0.7750.38
141_T147_S0.7740.38
125_E154_E0.7730.38
315_M318_L0.7730.38
93_R125_E0.7730.38
33_C44_V0.7720.38
179_I259_I0.7720.38
273_L318_L0.7690.38
302_H306_D0.7690.38
108_I120_A0.7690.38
385_G391_G0.7680.38
47_K78_E0.7660.37
171_M301_S0.7630.37
358_G382_L0.7570.37
349_R389_P0.7570.37
357_G376_E0.7560.37
143_H147_S0.7560.37
103_V130_M0.7520.36
189_A194_A0.7510.36
21_L44_V0.7510.36
357_G373_C0.7500.36
382_L392_C0.7460.36
189_A256_I0.7420.36
378_C387_V0.7410.36
288_Y293_V0.7380.35
336_Y373_C0.7380.35
372_H375_T0.7380.35
353_S381_C0.7360.35
372_H376_E0.7360.35
121_R166_G0.7360.35
375_T385_G0.7360.35
357_G383_L0.7360.35
353_S378_C0.7350.35
373_C383_L0.7350.35
45_V164_K0.7340.35
73_G224_S0.7330.35
14_K165_R0.7300.35
23_S178_N0.7290.35
128_A132_E0.7280.35
377_K380_G0.7270.35
48_T202_T0.7260.35
209_I318_L0.7240.34
333_Y385_G0.7230.34
310_D318_L0.7210.34
363_E371_P0.7210.34
356_D383_L0.7170.34
337_P343_K0.7160.34
357_G386_H0.7150.34
23_S61_F0.7140.34
116_W194_A0.7140.34
101_D220_V0.7130.34
273_L309_F0.7120.34
8_I278_T0.7070.33
56_E59_P0.7070.33
344_C349_R0.7070.33
8_I272_L0.7050.33
338_R342_D0.7040.33
51_F115_Q0.7030.33
200_I234_V0.7000.33
346_G358_G0.6970.33
154_E187_L0.6940.32
298_S302_H0.6920.32
350_C384_C0.6910.32
376_E381_C0.6910.32
351_Y359_H0.6890.32
70_G75_K0.6880.32
38_D311_S0.6850.32
359_H378_C0.6840.32
138_P231_G0.6830.32
206_I274_L0.6820.32
353_S386_H0.6820.32
11_C172_L0.6820.32
357_G361_A0.6790.31
354_C384_C0.6780.31
387_V391_G0.6760.31
346_G371_P0.6750.31
200_I258_G0.6750.31
264_T299_G0.6740.31
168_T190_K0.6730.31
165_R168_T0.6730.31
378_C393_I0.6690.31
256_I305_A0.6680.31
297_A301_S0.6680.31
358_G377_K0.6670.31
105_I130_M0.6670.31
291_R300_L0.6670.31
339_I345_V0.6660.31
375_T383_L0.6620.30
136_S147_S0.6620.30
390_V393_I0.6600.30
99_Y312_L0.6560.30
169_L191_R0.6540.30
86_E96_K0.6530.30
136_S260_G0.6520.30
363_E386_H0.6510.30
207_T224_S0.6490.29
348_G378_C0.6440.29
156_V189_A0.6440.29
20_C45_V0.6430.29
86_E121_R0.6410.29
303_Y307_Q0.6410.29
202_T260_G0.6390.29
346_G357_G0.6360.29
25_P110_G0.6350.29
350_C388_C0.6340.29
359_H382_L0.6340.29
132_E194_A0.6330.28
352_I391_G0.6320.28
344_C392_C0.6310.28
341_L390_V0.6310.28
47_K282_T0.6290.28
106_A123_V0.6290.28
9_T298_S0.6290.28
375_T389_P0.6270.28
60_R78_E0.6270.28
61_F79_Q0.6260.28
16_P169_L0.6240.28
260_G283_T0.6220.28
344_C393_I0.6220.28
372_H385_G0.6210.28
129_D260_G0.6210.28
375_T393_I0.6190.28
37_Y44_V0.6180.28
265_W303_Y0.6180.28
53_I56_E0.6160.27
334_I339_I0.6150.27
361_A377_K0.6150.27
150_G176_T0.6150.27
118_E327_E0.6120.27
246_R253_D0.6120.27
48_T199_A0.6070.27
64_L67_E0.6070.27
114_Q219_I0.6070.27
99_Y102_K0.6060.27
349_R386_H0.6040.27
356_D378_C0.6040.27
94_R118_E0.6030.27
342_D363_E0.6030.27
354_C388_C0.6020.27
341_L346_G0.6020.27
25_P260_G0.6000.26
45_V105_I0.5990.26
344_C356_D0.5960.26
344_C379_V0.5950.26
158_K161_R0.5940.26
333_Y338_R0.5940.26
348_G359_H0.5930.26
59_P220_V0.5910.26
41_W76_N0.5900.26
263_E267_D0.5880.26
118_E125_E0.5880.26
227_S231_G0.5880.26
375_T378_C0.5880.26
25_P259_I0.5880.26
340_N358_G0.5870.26
357_G380_G0.5870.26
344_C383_L0.5860.26
96_K100_P0.5860.26
376_E380_G0.5850.26
156_V179_I0.5840.26
377_K386_H0.5830.25
197_I242_I0.5830.25
80_I83_H0.5810.25
116_W134_N0.5800.25
87_E162_A0.5790.25
351_Y371_P0.5780.25
292_I296_M0.5780.25
131_I298_S0.5770.25
5_D305_A0.5770.25
238_A260_G0.5750.25
48_T108_I0.5750.25
4_K7_S0.5750.25
382_L386_H0.5740.25
344_C382_L0.5730.25
334_I338_R0.5700.25
72_I77_M0.5690.25
23_S29_C0.5690.25
43_G201_N0.5680.25
117_E122_L0.5670.25
376_E386_H0.5670.25
21_L36_A0.5660.24
39_T294_E0.5640.24
187_L306_D0.5640.24
262_I281_V0.5620.24
114_Q123_V0.5620.24
39_T345_V0.5620.24
58_S67_E0.5620.24
161_R266_E0.5610.24
349_R359_H0.5600.24
155_L176_T0.5600.24
358_G370_T0.5600.24
39_T212_N0.5600.24
350_C354_C0.5590.24
259_I278_T0.5580.24
200_I241_F0.5580.24
134_N387_V0.5550.24
105_I249_P0.5550.24
339_I342_D0.5550.24
124_Q131_I0.5530.24
242_I258_G0.5530.24
202_T241_F0.5520.24
328_D341_L0.5520.24
377_K382_L0.5520.24
140_M147_S0.5510.24
190_K253_D0.5500.24
27_G46_F0.5470.23
339_I393_I0.5470.23
339_I343_K0.5470.23
333_Y336_Y0.5460.23
151_Q182_M0.5440.23
349_R376_E0.5440.23
301_S312_L0.5430.23
300_L309_F0.5420.23
158_K162_A0.5420.23
123_V297_A0.5400.23
140_M144_A0.5390.23
359_H377_K0.5380.23
144_A148_D0.5380.23
295_D299_G0.5380.23
181_D184_E0.5360.23
30_Y34_A0.5360.23
236_P260_G0.5360.23
207_T304_L0.5350.23
380_G393_I0.5340.23
70_G76_N0.5330.23
352_I382_L0.5310.23
348_G389_P0.5310.23
353_S391_G0.5300.22
358_G373_C0.5290.22
379_V387_V0.5290.22
346_G356_D0.5270.22
47_K280_Q0.5260.22
337_P393_I0.5250.22
76_N84_P0.5240.22
349_R378_C0.5230.22
141_T144_A0.5220.22
338_R343_K0.5220.22
342_D372_H0.5200.22
348_G377_K0.5190.22
146_G176_T0.5190.22
336_Y351_Y0.5180.22
21_L282_T0.5180.22
9_T154_E0.5160.22
334_I385_G0.5150.22
309_F314_E0.5140.22
380_G389_P0.5140.22
349_R356_D0.5130.22
329_L333_Y0.5130.22
338_R353_S0.5130.22
289_G293_V0.5130.22
21_L37_Y0.5120.22
168_T253_D0.5120.22
53_I57_V0.5120.22
22_S59_P0.5110.21
348_G356_D0.5110.21
352_I372_H0.5100.21
17_N42_G0.5100.21
84_P157_E0.5090.21
343_K372_H0.5070.21
181_D262_I0.5070.21
45_V198_A0.5050.21
104_L151_Q0.5050.21
308_G324_V0.5050.21
346_G370_T0.5040.21
60_R138_P0.5040.21
346_G376_E0.5040.21
50_G75_K0.5040.21
23_S27_G0.5040.21
327_E330_D0.5040.21
180_G186_A0.5030.21
113_E117_E0.5020.21
76_N228_G0.5020.21
383_L387_V0.5020.21
159_Y199_A0.5010.21
233_A260_G0.5000.21
344_C353_S0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1gteA 4 0.9805 100 0.49 Contact Map
4ef8A 2 0.747 100 0.609 Contact Map
4cq8A 1 0.7299 100 0.615 Contact Map
1tv5A 3 0.7202 100 0.626 Contact Map
1ep3A 2 0.7445 100 0.628 Contact Map
4oqvA 1 0.7129 100 0.63 Contact Map
2e6fA 2 0.7421 100 0.645 Contact Map
1jubA 2 0.7421 100 0.647 Contact Map
3oixA 3 0.7299 100 0.648 Contact Map
1f76A 1 0.6764 100 0.694 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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