GREMLIN Database
RHLE - ATP-dependent RNA helicase RhlE
UniProt: P25888 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11235
Length: 454 (361)
Sequences: 35836 (19644)
Seq/√Len: 1033.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
56_T95_V4.4671.00
59_L78_A3.9091.00
35_V184_L3.6661.00
82_T91_I3.2511.00
273_A296_I3.1341.00
290_D295_D2.9071.00
289_A293_S2.8061.00
255_K278_N2.7671.00
262_A272_S2.7121.00
252_T258_A2.6531.00
131_A136_L2.6391.00
92_G96_R2.6261.00
273_A290_D2.5671.00
286_R290_D2.5491.00
27_I43_A2.5031.00
262_A274_A2.4291.00
237_S268_D2.4071.00
18_E101_Y2.4061.00
259_N274_A2.3931.00
39_R206_L2.3471.00
271_R297_R2.2851.00
107_L126_V2.2321.00
92_G106_S2.2001.00
262_A266_N2.1961.00
252_T261_L2.1231.00
333_I345_A2.1121.00
167_I170_I2.1061.00
221_T344_E2.0931.00
252_T300_V2.0731.00
167_I171_R2.0431.00
285_T289_A2.0411.00
139_L144_A2.0381.00
92_G108_V2.0371.00
248_V316_H2.0261.00
62_H152_I1.9821.00
158_A185_L1.9731.00
316_H346_L1.9391.00
168_H171_R1.9271.00
233_R264_Q1.9261.00
257_G321_E1.9051.00
246_Q315_P1.8941.00
169_D172_R1.8911.00
273_A287_A1.8481.00
77_R151_E1.8181.00
61_Q65_T1.8061.00
94_N97_D1.7861.00
258_A276_H1.7811.00
195_K199_E1.7731.00
270_I298_V1.7711.00
223_H344_E1.7451.00
235_L238_H1.7421.00
21_Y53_A1.7371.00
55_F154_V1.7301.00
89_A285_T1.7241.00
322_L347_S1.7161.00
78_A152_I1.7141.00
116_N120_M1.7051.00
105_R127_D1.7031.00
265_L300_V1.6801.00
55_F186_F1.6721.00
95_V128_V1.6701.00
258_A274_A1.6641.00
301_A305_A1.6621.00
222_Q329_Y1.6591.00
248_V318_V1.6461.00
305_A309_L1.6241.00
313_E341_A1.6141.00
35_V41_L1.6021.00
160_R163_D1.5951.00
264_Q268_D1.5941.00
171_R200_K1.5811.00
222_Q333_I1.5801.00
19_Q97_D1.5751.00
46_Q49_T1.5751.00
43_A186_F1.5681.00
319_N333_I1.5361.00
280_S283_A1.5321.00
137_L172_R1.5181.00
59_L154_V1.5121.00
261_L320_Y1.5121.00
141_H172_R1.5101.00
95_V106_S1.5061.00
319_N347_S1.4951.00
114_S117_P1.4951.00
254_T257_G1.4921.00
31_A54_G1.4831.00
323_P329_Y1.4761.00
168_H172_R1.4641.00
77_R127_D1.4471.00
194_I197_L1.4461.00
34_A206_L1.4451.00
247_Q313_E1.4401.00
241_G268_D1.4381.00
257_G260_H1.4281.00
316_H344_E1.4181.00
75_P149_Q1.4171.00
195_K207_E1.4071.00
82_T88_A1.3981.00
33_P37_E1.3941.00
88_A108_V1.3921.00
237_S241_G1.3881.00
248_V298_V1.3841.00
79_L150_V1.3761.00
325_V328_D1.3751.00
59_L152_I1.3751.00
236_L318_V1.3711.00
279_K287_A1.3701.00
93_E97_D1.3691.00
197_L202_L1.3681.00
153_L183_N1.3541.00
107_L121_K1.3531.00
34_A37_E1.3531.00
357_L361_E1.3451.00
62_H151_E1.3381.00
290_D296_I1.3301.00
89_A93_E1.3301.00
16_V21_Y1.3251.00
239_M346_L1.3231.00
166_F170_I1.3131.00
35_V58_P1.3111.00
81_L136_L1.2971.00
34_A41_L1.2891.00
140_E176_K1.2881.00
266_N272_S1.2871.00
18_E100_K1.2821.00
36_L61_Q1.2811.00
17_A22_R1.2671.00
126_V129_L1.2651.00
159_D307_R1.2651.00
172_R176_K1.2621.00
29_Q33_P1.2571.00
239_M242_K1.2441.00
262_A300_V1.2441.00
87_L308_G1.2381.00
317_V336_T1.2321.00
261_L300_V1.2311.00
344_E347_S1.2241.00
172_R175_T1.2221.00
259_N276_H1.2141.00
283_A287_A1.2081.00
283_A286_R1.2051.00
250_V298_V1.2041.00
245_W248_V1.1941.00
44_S209_E1.1841.00
359_D363_L1.1781.00
153_L174_L1.1771.00
287_A296_I1.1721.00
55_F91_I1.1611.00
279_K283_A1.1571.00
236_L320_Y1.1531.00
116_N119_M1.1481.00
137_L169_D1.1401.00
358_R361_E1.1371.00
174_L177_L1.1251.00
319_N332_R1.1221.00
171_R175_T1.1211.00
95_V130_V1.1161.00
233_R237_S1.1091.00
197_L201_L1.1091.00
107_L129_L1.1081.00
258_A262_A1.0951.00
239_M318_V1.0941.00
234_E237_S1.0941.00
38_G62_H1.0871.00
231_R234_E1.0841.00
32_I36_L1.0811.00
197_L203_H1.0771.00
247_Q294_G1.0751.00
232_K321_E1.0751.00
92_G130_V1.0721.00
220_V337_G1.0691.00
241_G270_I1.0511.00
81_L131_A1.0501.00
93_E96_R1.0481.00
26_P30_Q1.0381.00
256_H260_H1.0371.00
364_L367_E1.0341.00
258_A300_V1.0331.00
170_I173_V1.0321.00
361_E364_L1.0251.00
354_H358_R1.0211.00
118_Q121_K1.0161.00
211_A214_N1.0131.00
166_F169_D0.9981.00
291_F299_L0.9961.00
137_L141_H0.9951.00
228_D231_R0.9921.00
233_R268_D0.9911.00
287_A299_L0.9811.00
276_H279_K0.9771.00
217_S220_V0.9741.00
45_A49_T0.9731.00
275_I305_A0.9731.00
138_D142_Q0.9691.00
281_Q285_T0.9671.00
232_K239_M0.9621.00
53_A57_L0.9611.00
31_A43_A0.9601.00
355_K359_D0.9591.00
52_T91_I0.9571.00
60_L99_S0.9541.00
117_P120_M0.9541.00
263_E266_N0.9481.00
196_A200_K0.9471.00
191_S194_I0.9471.00
372_A375_G0.9441.00
115_I119_M0.9411.00
237_S264_Q0.9411.00
94_N310_D0.9401.00
236_L250_V0.9351.00
289_A292_K0.9351.00
170_I174_L0.9331.00
235_L239_M0.9291.00
193_D196_A0.9251.00
87_L90_Q0.9251.00
115_I142_Q0.9241.00
113_V118_Q0.9231.00
30_Q34_A0.9221.00
375_G379_D0.9211.00
88_A130_V0.9211.00
240_I248_V0.9161.00
375_G378_P0.9091.00
368_I372_A0.9031.00
118_Q122_L0.8971.00
119_M144_A0.8971.00
275_I304_I0.8961.00
356_L359_D0.8941.00
90_Q310_D0.8891.00
361_E367_E0.8871.00
235_L348_L0.8861.00
233_R320_Y0.8831.00
131_A145_V0.8821.00
78_A154_V0.8821.00
194_I198_A0.8791.00
238_H242_K0.8791.00
34_A39_R0.8771.00
38_G182_Q0.8741.00
221_T342_T0.8731.00
192_D196_A0.8601.00
63_L78_A0.8561.00
227_V235_L0.8551.00
26_P29_Q0.8521.00
94_N98_Y0.8501.00
66_R151_E0.8491.00
353_E356_L0.8481.00
245_W297_R0.8451.00
169_D173_V0.8411.00
63_L104_I0.8401.00
219_Q342_T0.8361.00
193_D197_L0.8341.00
357_L360_I0.8321.00
207_E211_A0.8311.00
249_L301_A0.8301.00
115_I118_Q0.8291.00
62_H182_Q0.8271.00
253_R324_N0.8251.00
380_P383_K0.8241.00
43_A184_L0.8211.00
41_L184_L0.8181.00
54_G58_P0.8161.00
120_M123_R0.8141.00
264_Q267_K0.8131.00
247_Q315_P0.8091.00
286_R289_A0.8031.00
166_F171_R0.8011.00
232_K235_L0.8011.00
197_L200_K0.8001.00
78_A128_V0.7941.00
198_A201_L0.7941.00
89_A108_V0.7931.00
32_I57_L0.7911.00
260_H264_Q0.7891.00
195_K198_A0.7871.00
239_M316_H0.7841.00
59_L95_V0.7841.00
292_K313_E0.7821.00
259_N263_E0.7801.00
167_I174_L0.7771.00
61_Q64_I0.7761.00
171_R174_L0.7741.00
154_V184_L0.7741.00
368_I373_I0.7731.00
53_A94_N0.7721.00
209_E212_R0.7711.00
110_F113_V0.7701.00
371_I375_G0.7681.00
288_L311_I0.7681.00
303_D328_D0.7641.00
211_A216_A0.7621.00
251_F332_R0.7621.00
187_S190_F0.7621.00
196_A199_E0.7611.00
353_E357_L0.7601.00
40_D185_L0.7591.00
42_M190_F0.7561.00
374_P377_E0.7541.00
159_D331_H0.7531.00
291_F314_L0.7521.00
365_K368_I0.7521.00
355_K358_R0.7511.00
140_E147_L0.7481.00
225_H235_L0.7451.00
62_H65_T0.7441.00
229_K257_G0.7421.00
152_I184_L0.7421.00
223_H226_F0.7401.00
64_I102_L0.7371.00
109_V118_Q0.7351.00
335_R338_R0.7341.00
152_I182_Q0.7321.00
282_G286_R0.7301.00
168_H173_V0.7301.00
173_V177_L0.7291.00
287_A290_D0.7281.00
99_S106_S0.7281.00
221_T369_P0.7271.00
374_P378_P0.7271.00
349_V352_D0.7231.00
204_N207_E0.7231.00
363_L366_K0.7221.00
113_V117_P0.7221.00
89_A92_G0.7211.00
238_H241_G0.7191.00
188_A334_G0.7151.00
303_D332_R0.7141.00
23_E29_Q0.7121.00
234_E268_D0.7121.00
379_D382_I0.7121.00
59_L80_I0.7121.00
233_R260_H0.7101.00
360_I364_L0.7091.00
306_A328_D0.7071.00
288_L292_K0.7041.00
106_S109_V0.7001.00
361_E368_I0.6971.00
147_L150_V0.6961.00
234_E238_H0.6881.00
215_T218_D0.6871.00
257_G320_Y0.6871.00
47_T334_G0.6841.00
44_S190_F0.6831.00
360_I363_L0.6811.00
135_R138_D0.6801.00
62_H66_R0.6791.00
39_R204_N0.6781.00
47_T188_A0.6771.00
31_A35_V0.6761.00
368_I374_P0.6761.00
99_S102_L0.6761.00
237_S270_I0.6751.00
376_Y379_D0.6751.00
117_P121_K0.6741.00
250_V318_V0.6741.00
64_I77_R0.6731.00
364_L368_I0.6731.00
319_N323_P0.6691.00
199_E203_H0.6671.00
314_L336_T0.6641.00
373_I377_E0.6601.00
33_P36_L0.6601.00
40_D183_N0.6591.00
294_G297_R0.6581.00
370_R374_P0.6551.00
249_L299_L0.6551.00
233_R261_L0.6551.00
271_R296_I0.6521.00
270_I297_R0.6511.00
220_V345_A0.6511.00
212_R215_T0.6501.00
131_A135_R0.6501.00
322_L360_I0.6461.00
253_R321_E0.6461.00
361_E365_K0.6451.00
178_P181_R0.6451.00
240_I270_I0.6441.00
85_R112_G0.6421.00
359_D362_K0.6421.00
202_L205_P0.6421.00
354_H357_L0.6411.00
170_I176_K0.6401.00
167_I178_P0.6401.00
358_R362_K0.6391.00
232_K236_L0.6391.00
76_V151_E0.6381.00
109_V129_L0.6371.00
350_C353_E0.6361.00
349_V357_L0.6351.00
16_V53_A0.6341.00
56_T106_S0.6291.00
357_L367_E0.6281.00
40_D205_P0.6271.00
377_E380_P0.6261.00
247_Q297_R0.6251.00
192_D195_K0.6251.00
288_L291_F0.6241.00
168_H175_T0.6231.00
323_P332_R0.6231.00
372_A376_Y0.6211.00
194_I201_L0.6201.00
43_A54_G0.6201.00
167_I177_L0.6191.00
376_Y380_P0.6191.00
158_A190_F0.6181.00
368_I375_G0.6171.00
357_L368_I0.6151.00
247_Q291_F0.6141.00
224_V349_V0.6121.00
174_L181_R0.6111.00
60_L102_L0.6101.00
79_L153_L0.6101.00
53_A98_Y0.6101.00
374_P379_D0.6091.00
355_K360_I0.6081.00
363_L367_E0.6071.00
91_I94_N0.6061.00
367_E371_I0.6051.00
80_I95_V0.6041.00
285_T288_L0.6041.00
256_H259_N0.6041.00
368_I371_I0.6031.00
294_G313_E0.6021.00
170_I178_P0.6021.00
198_A202_L0.6021.00
269_G272_S0.6021.00
236_L261_L0.6011.00
40_D203_H0.6001.00
207_E210_V0.5991.00
89_A110_F0.5991.00
211_A215_T0.5971.00
118_Q135_R0.5951.00
115_I139_L0.5951.00
307_R331_H0.5941.00
120_M124_G0.5931.00
166_F173_V0.5911.00
193_D201_L0.5881.00
274_A279_K0.5881.00
59_L128_V0.5881.00
263_E267_K0.5871.00
250_V320_Y0.5841.00
34_A208_I0.5841.00
273_A299_L0.5841.00
222_Q226_F0.5831.00
30_Q208_I0.5821.00
171_R177_L0.5821.00
108_V111_G0.5811.00
216_A219_Q0.5811.00
247_Q314_L0.5801.00
119_M139_L0.5801.00
82_T132_T0.5801.00
93_E292_K0.5801.00
356_L360_I0.5781.00
255_K276_H0.5771.00
223_H346_L0.5751.00
170_I177_L0.5741.00
119_M123_R0.5731.00
96_R100_K0.5731.00
239_M348_L0.5721.00
63_L127_D0.5711.00
221_T224_V0.5711.00
373_I376_Y0.5711.00
226_F354_H0.5691.00
97_D100_K0.5681.00
348_L352_D0.5681.00
249_L314_L0.5681.00
40_D202_L0.5671.00
371_I374_P0.5671.00
175_T178_P0.5641.00
284_R288_L0.5641.00
189_T331_H0.5641.00
255_K259_N0.5611.00
214_N217_S0.5611.00
369_P372_A0.5571.00
57_L61_Q0.5571.00
134_G137_L0.5571.00
88_A110_F0.5561.00
253_R257_G0.5561.00
16_V57_L0.5551.00
55_F58_P0.5541.00
205_P208_I0.5531.00
154_V186_F0.5521.00
42_M185_L0.5501.00
40_D182_Q0.5501.00
324_N356_L0.5501.00
233_R236_L0.5491.00
308_G338_R0.5481.00
223_H371_I0.5461.00
308_G335_R0.5451.00
361_E366_K0.5441.00
169_D176_K0.5441.00
329_Y333_I0.5441.00
365_K369_P0.5431.00
55_F82_T0.5431.00
118_Q139_L0.5411.00
367_E370_R0.5411.00
27_I45_A0.5391.00
84_T307_R0.5381.00
302_T332_R0.5381.00
60_L64_I0.5381.00
378_P381_S0.5371.00
42_M198_A0.5361.00
290_D293_S0.5351.00
137_L140_E0.5351.00
36_L62_H0.5351.00
82_T130_V0.5351.00
95_V99_S0.5351.00
362_K365_K0.5341.00
76_V129_L0.5321.00
200_K203_H0.5321.00
357_L363_L0.5311.00
236_L240_I0.5311.00
371_I378_P0.5291.00
259_N278_N0.5241.00
195_K202_L0.5221.00
16_V20_G0.5221.00
16_V19_Q0.5211.00
370_R376_Y0.5201.00
91_I130_V0.5191.00
220_V229_K0.5191.00
234_E264_Q0.5181.00
361_E370_R0.5171.00
90_Q94_N0.5171.00
146_K149_Q0.5161.00
160_R307_R0.5151.00
369_P373_I0.5131.00
224_V227_V0.5131.00
58_P152_I0.5131.00
271_R290_D0.5131.00
367_E372_A0.5121.00
275_I301_A0.5121.00
238_H268_D0.5111.00
229_K350_C0.5111.00
96_R106_S0.5091.00
85_R281_Q0.5091.00
246_Q316_H0.5081.00
292_K312_E0.5081.00
256_H278_N0.5071.00
312_E341_A0.5061.00
104_I127_D0.5051.00
224_V228_D0.5051.00
222_Q366_K0.5031.00
208_I211_A0.5011.00
318_V346_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pxaA 1 0.837 100 0.251 Contact Map
4nhoA 1 0.8216 100 0.255 Contact Map
4c9bA 1 0.8172 100 0.263 Contact Map
2db3A 1 0.8238 100 0.263 Contact Map
4ljyA 1 0.8634 100 0.266 Contact Map
4d25A 1 0.8282 100 0.266 Contact Map
3eiqA 1 0.7753 100 0.272 Contact Map
1s2mA 1 0.8304 100 0.278 Contact Map
4ct4B 1 0.8216 100 0.28 Contact Map
4kbfA 2 0.804 100 0.284 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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