GREMLIN Database
GALS - HTH-type transcriptional regulator GalS
UniProt: P25748 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10365
Length: 346 (325)
Sequences: 35708 (26149)
Seq/√Len: 1450.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
176_H239_T3.6511.00
161_L200_S3.5551.00
10_Q42_E3.2731.00
262_A265_L3.1351.00
167_A270_I2.6801.00
274_D289_R2.6771.00
154_R306_G2.5531.00
176_H268_S2.5101.00
118_A303_A2.5091.00
195_K199_M2.4361.00
165_R204_E2.4081.00
225_E258_D2.2891.00
84_V87_Q2.2411.00
84_V301_E2.2301.00
38_K42_E2.2231.00
34_E38_K2.2221.00
30_A34_E2.2031.00
298_L301_E2.1411.00
169_R173_N2.1081.00
174_N329_V2.0961.00
80_A296_A2.0861.00
224_G251_G2.0821.00
165_R200_S2.0591.00
233_G259_N2.0541.00
164_A168_T2.0301.00
172_L205_Q2.0101.00
163_G272_F2.0031.00
229_V259_N1.9881.00
256_L267_L1.9471.00
85_A300_T1.9431.00
33_R37_M1.9391.00
305_Q310_N1.9261.00
165_R201_A1.9241.00
21_V36_V1.8821.00
162_S166_M1.8671.00
22_L40_V1.8611.00
161_L196_A1.8461.00
169_R201_A1.8021.00
83_L293_A1.8001.00
164_A242_F1.7711.00
229_V255_A1.7411.00
5_R15_V1.7291.00
289_R322_T1.7211.00
165_R169_R1.7021.00
171_L240_A1.6811.00
169_R205_Q1.6791.00
261_I266_H1.6791.00
225_E255_A1.6711.00
228_M241_V1.6681.00
63_G116_C1.6351.00
228_M252_A1.6281.00
84_V297_K1.6251.00
11_A39_A1.6181.00
291_P294_S1.5971.00
262_A266_H1.5931.00
80_A293_A1.5911.00
274_D326_R1.5881.00
166_M321_P1.5881.00
168_T198_W1.5701.00
159_D162_S1.5551.00
284_Q327_H1.5431.00
181_Y244_Y1.5231.00
196_A200_S1.5121.00
180_G238_L1.4961.00
37_M41_S1.4961.00
298_L317_H1.4931.00
243_A252_A1.4911.00
10_Q39_A1.4901.00
178_R210_P1.4861.00
178_R237_Q1.4741.00
168_T172_L1.4671.00
84_V300_T1.4471.00
172_L201_A1.4321.00
162_S165_R1.4281.00
144_I299_A1.4261.00
168_T197_G1.4241.00
21_V40_V1.4221.00
229_V258_D1.4131.00
7_V39_A1.4091.00
37_M40_V1.4061.00
170_M174_N1.4001.00
164_A197_G1.3991.00
257_K282_D1.3931.00
255_A259_N1.3911.00
193_M196_A1.3851.00
294_S298_L1.3811.00
163_G321_P1.3751.00
294_S297_K1.3731.00
270_I286_T1.3581.00
132_A136_D1.3571.00
7_V11_A1.3531.00
301_E305_Q1.3511.00
215_G230_E1.3471.00
84_V88_H1.3471.00
199_M203_K1.3461.00
88_H304_L1.3431.00
176_H240_A1.3411.00
60_D117_N1.3311.00
180_G231_L1.3281.00
170_M173_N1.3101.00
63_G111_L1.3061.00
256_L261_I1.3061.00
168_T201_A1.3001.00
95_G111_L1.2891.00
170_M329_V1.2841.00
255_A258_D1.2811.00
62_I85_A1.2731.00
210_P213_W1.2681.00
60_D90_K1.2661.00
225_E254_T1.2641.00
218_T223_G1.2491.00
6_D9_R1.2491.00
29_S32_T1.2441.00
235_N238_L1.2421.00
225_E229_V1.2351.00
197_G201_A1.2291.00
228_M256_L1.2281.00
178_R239_T1.2261.00
20_R25_S1.2201.00
169_R204_E1.2191.00
170_M325_R1.2111.00
246_D287_T1.2111.00
4_I18_V1.2031.00
39_A43_L1.2011.00
182_L252_A1.1981.00
30_A33_R1.1961.00
5_R9_R1.1901.00
81_V300_T1.1861.00
109_E133_Q1.1781.00
81_V120_I1.1751.00
64_V81_V1.1731.00
198_W202_L1.1721.00
268_S329_V1.1721.00
230_E234_R1.1681.00
241_V252_A1.1671.00
85_A92_V1.1651.00
10_Q43_L1.1611.00
120_I299_A1.1561.00
229_V233_G1.1541.00
253_L269_I1.1511.00
7_V43_L1.1461.00
201_A204_E1.1421.00
304_L308_A1.1421.00
251_G255_A1.1381.00
161_L193_M1.1361.00
222_P226_A1.1341.00
95_G107_A1.1331.00
173_N205_Q1.1291.00
161_L165_R1.1271.00
48_N54_L1.1211.00
166_M169_R1.1201.00
179_I202_L1.1061.00
226_A230_E1.1051.00
48_N51_A1.1011.00
246_D271_G1.0931.00
4_I15_V1.0881.00
293_A297_K1.0841.00
172_L207_I1.0831.00
35_A39_A1.0821.00
174_N325_R1.0731.00
200_S204_E1.0721.00
39_A42_E1.0721.00
64_V92_V1.0661.00
21_V28_V1.0621.00
224_G228_M1.0591.00
82_D86_Q1.0591.00
38_K41_S1.0561.00
161_L197_G1.0461.00
167_A242_F1.0461.00
177_Q239_T1.0421.00
32_T35_A1.0361.00
220_D223_G1.0241.00
184_S219_P1.0221.00
302_L317_H1.0201.00
88_H301_E1.0161.00
181_Y195_K1.0151.00
178_R236_L1.0071.00
88_H308_A1.0021.00
296_A300_T0.9981.00
158_L291_P0.9981.00
198_W242_F0.9931.00
187_G192_A0.9921.00
50_N53_A0.9911.00
40_V43_L0.9901.00
298_L302_L0.9841.00
83_L297_K0.9761.00
24_N33_R0.9711.00
174_N268_S0.9701.00
253_L281_T0.9651.00
243_A249_A0.9651.00
34_E37_M0.9631.00
105_R109_E0.9611.00
87_Q297_K0.9551.00
215_G227_A0.9541.00
167_A288_V0.9531.00
159_D318_C0.9491.00
64_V78_V0.9481.00
61_T91_Y0.9471.00
243_A248_M0.9461.00
298_L319_F0.9431.00
253_L263_I0.9411.00
61_T93_L0.9401.00
86_Q103_K0.9381.00
297_K301_E0.9291.00
291_P319_F0.9221.00
303_A307_A0.9191.00
179_I240_A0.9181.00
51_A54_L0.9171.00
271_G287_T0.9171.00
228_M232_L0.9141.00
103_K106_H0.9131.00
196_A199_M0.9131.00
11_A18_V0.9121.00
217_G248_M0.9101.00
90_K304_L0.9081.00
202_L207_I0.9041.00
59_S117_N0.8961.00
246_D274_D0.8951.00
120_I303_A0.8911.00
109_E113_R0.8911.00
192_A196_A0.8871.00
273_D290_Y0.8871.00
227_A230_E0.8841.00
47_P52_Q0.8841.00
17_T20_R0.8831.00
186_H216_A0.8811.00
178_R213_W0.8791.00
201_A205_Q0.8781.00
274_D278_A0.8751.00
232_L255_A0.8731.00
199_M209_P0.8671.00
158_L290_Y0.8641.00
223_G226_A0.8631.00
168_T202_L0.8601.00
76_A293_A0.8591.00
62_I120_I0.8581.00
170_M286_T0.8561.00
162_S321_P0.8531.00
31_D34_E0.8531.00
162_S320_M0.8521.00
322_T325_R0.8471.00
159_D320_M0.8401.00
81_V296_A0.8371.00
226_A229_V0.8361.00
256_L269_I0.8361.00
81_V92_V0.8341.00
289_R324_V0.8331.00
221_M254_T0.8331.00
155_C316_S0.8321.00
172_L177_Q0.8261.00
325_R329_V0.8251.00
156_V302_L0.8231.00
274_D324_V0.8211.00
261_I267_L0.8191.00
202_L209_P0.8131.00
79_K83_L0.8111.00
180_G241_V0.8091.00
239_T268_S0.8061.00
73_F292_I0.8051.00
246_D249_A0.8031.00
21_V37_M0.8021.00
234_R238_L0.8001.00
278_A281_T0.7991.00
112_I137_N0.7991.00
80_A297_K0.7991.00
200_S203_K0.7991.00
286_T329_V0.7981.00
158_L321_P0.7961.00
100_E103_K0.7931.00
250_A281_T0.7921.00
160_N194_R0.7911.00
46_R113_R0.7841.00
24_N37_M0.7841.00
237_Q261_I0.7821.00
213_W234_R0.7811.00
277_I281_T0.7811.00
181_Y242_F0.7781.00
189_E193_M0.7771.00
67_M74_F0.7771.00
133_Q136_D0.7731.00
223_G227_A0.7711.00
170_M323_L0.7701.00
106_H109_E0.7681.00
58_V117_N0.7631.00
309_G312_D0.7621.00
195_K214_I0.7621.00
134_F141_M0.7591.00
20_R26_T0.7591.00
157_C318_C0.7591.00
154_R315_A0.7591.00
171_L270_I0.7571.00
193_M197_G0.7571.00
182_L243_A0.7561.00
49_A52_Q0.7561.00
234_R237_Q0.7531.00
291_P322_T0.7521.00
257_K284_Q0.7471.00
300_T304_L0.7451.00
20_R27_L0.7411.00
232_L259_N0.7371.00
241_V267_L0.7361.00
77_L144_I0.7361.00
228_M231_L0.7321.00
83_L87_Q0.7311.00
302_L305_Q0.7301.00
154_R302_L0.7271.00
177_Q207_I0.7251.00
165_R197_G0.7241.00
209_P212_S0.7231.00
58_V308_A0.7211.00
215_G231_L0.7171.00
63_G119_L0.7141.00
118_A307_A0.7131.00
166_M288_V0.7131.00
98_Y103_K0.7121.00
286_T323_L0.7111.00
34_E41_S0.7091.00
228_M251_G0.7091.00
13_V36_V0.7071.00
62_I300_T0.7061.00
61_T114_Q0.7051.00
242_F270_I0.7021.00
209_P214_I0.7011.00
179_I198_W0.6981.00
5_R55_A0.6981.00
16_A20_R0.6981.00
112_I139_P0.6971.00
103_K107_A0.6941.00
178_R208_I0.6941.00
145_N160_N0.6921.00
230_E233_G0.6911.00
31_D35_A0.6911.00
228_M255_A0.6911.00
293_A296_A0.6891.00
143_L148_V0.6881.00
270_I329_V0.6821.00
118_A142_V0.6821.00
79_K82_D0.6811.00
183_S195_K0.6811.00
80_A84_V0.6801.00
305_Q309_G0.6801.00
224_G227_A0.6791.00
245_N273_D0.6781.00
102_E106_H0.6781.00
286_T325_R0.6781.00
82_D92_V0.6751.00
217_G223_G0.6751.00
46_R109_E0.6741.00
27_L32_T0.6701.00
80_A292_I0.6671.00
18_V36_V0.6671.00
145_N190_D0.6651.00
7_V18_V0.6641.00
172_L202_L0.6641.00
179_I239_T0.6611.00
78_V94_I0.6601.00
120_I144_I0.6601.00
78_V82_D0.6591.00
41_S44_D0.6581.00
82_D96_N0.6531.00
254_T257_K0.6531.00
171_L242_F0.6511.00
305_Q315_A0.6481.00
249_A271_G0.6481.00
157_C316_S0.6451.00
71_D247_N0.6441.00
180_G213_W0.6431.00
256_L259_N0.6391.00
167_A240_A0.6391.00
135_M152_A0.6391.00
147_V316_S0.6371.00
295_M319_F0.6361.00
77_L292_I0.6341.00
65_V107_A0.6321.00
198_W209_P0.6321.00
93_L116_C0.6311.00
132_A135_M0.6291.00
219_P244_Y0.6281.00
108_I119_L0.6271.00
160_N193_M0.6261.00
21_V33_R0.6241.00
284_Q326_R0.6241.00
250_A275_I0.6191.00
143_L153_H0.6191.00
18_V21_V0.6181.00
184_S191_D0.6181.00
90_K117_N0.6171.00
254_T284_Q0.6171.00
191_D219_P0.6161.00
118_A299_A0.6161.00
62_I90_K0.6151.00
194_R290_Y0.6121.00
44_D47_P0.6081.00
35_A38_K0.6061.00
165_R168_T0.6031.00
238_L261_I0.6021.00
254_T258_D0.6001.00
18_V40_V0.6001.00
90_K307_A0.5981.00
272_F290_Y0.5951.00
219_P248_M0.5931.00
225_E251_G0.5931.00
181_Y198_W0.5901.00
242_F272_F0.5901.00
79_K293_A0.5901.00
79_K98_Y0.5891.00
116_C119_L0.5851.00
178_R238_L0.5851.00
166_M170_M0.5841.00
256_L263_I0.5831.00
135_M141_M0.5821.00
142_V302_L0.5821.00
129_D132_A0.5821.00
73_F77_L0.5791.00
85_A304_L0.5771.00
257_K262_A0.5771.00
25_S28_V0.5741.00
275_I287_T0.5731.00
97_S104_E0.5731.00
222_P225_E0.5701.00
258_D282_D0.5671.00
278_A287_T0.5671.00
221_M251_G0.5661.00
130_E133_Q0.5651.00
215_G234_R0.5641.00
62_I118_A0.5641.00
243_A271_G0.5621.00
13_V18_V0.5611.00
158_L163_G0.5611.00
142_V156_V0.5611.00
46_R50_N0.5571.00
20_R28_V0.5541.00
71_D74_F0.5531.00
283_P328_S0.5511.00
62_I307_A0.5511.00
217_G224_G0.5511.00
199_M211_E0.5481.00
302_L306_G0.5471.00
11_A36_V0.5471.00
274_D279_R0.5471.00
142_V299_A0.5461.00
142_V303_A0.5461.00
227_A231_L0.5451.00
191_D244_Y0.5441.00
306_G309_G0.5441.00
245_N248_M0.5421.00
76_A292_I0.5411.00
142_V306_G0.5381.00
174_N239_T0.5381.00
52_Q56_T0.5381.00
240_A268_S0.5371.00
232_L256_L0.5371.00
135_M153_H0.5351.00
183_S216_A0.5351.00
156_V298_L0.5341.00
99_H146_R0.5321.00
53_A56_T0.5301.00
72_A247_N0.5291.00
253_L257_K0.5291.00
168_T242_F0.5281.00
11_A21_V0.5271.00
306_G312_D0.5271.00
141_M153_H0.5261.00
84_V304_L0.5261.00
223_G248_M0.5251.00
283_P327_H0.5251.00
93_L114_Q0.5251.00
195_K216_A0.5251.00
278_A285_L0.5231.00
254_T282_D0.5221.00
13_V32_T0.5211.00
105_R130_E0.5211.00
167_A198_W0.5211.00
24_N27_L0.5171.00
59_S90_K0.5131.00
158_L272_F0.5121.00
26_T33_R0.5091.00
121_V143_L0.5081.00
111_L116_C0.5081.00
76_A276_P0.5071.00
119_L139_P0.5051.00
104_E123_S0.5041.00
183_S214_I0.5031.00
224_G248_M0.5011.00
25_S33_R0.5011.00
281_T284_Q0.5001.00
21_V27_L0.5001.00
63_G95_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3dbiA 2 0.7977 100 0.088 Contact Map
2hsgA 1 0.9451 100 0.09 Contact Map
1qpzA 2 0.974 100 0.095 Contact Map
2o20A 2 0.7948 100 0.096 Contact Map
3bilA 2 0.7399 100 0.102 Contact Map
4o5aA 2 0.7775 100 0.103 Contact Map
3e3mA 2 0.7746 100 0.104 Contact Map
3kjxA 2 0.9566 100 0.106 Contact Map
3ctpA 2 0.7659 100 0.107 Contact Map
3h5oA 2 0.7803 100 0.112 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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