GALS - ECOLI - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

GALS - HTH-type transcriptional regulator GalS

UniProt:	P25748	Sequences: MITIRDVARQAGVSVATVSRVLNNSTLVSADTREAVMKAVSELDYRPNANAQALATQVSDTIGVVVMDVSDAFFGALVKAVDLVAQQHQKYVLIGNSYHEAEKERHAIEVLIRQRCNALIVHSKALSDDELAQFMDNIPGMVLINRVVPGYAHRCVCLDNLSGARMATRMLLNNGHQRIGYLSSSHGIEDDAMRKAGWMSALKEQDIIPPESWIGAGTPDMPGGEAAMVELLGRNLQLTAVFAYNDNMAAGALTALKDNGIAIPLHLSIIGFDDIPIARYTDPQLTTVRYPIASMAKLATELALQGAAGNIDPRASHCFMPTLVRRHSVATRQNAAAITNSTNQAM	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10365
Length:	346 (325)
Sequences:	35708 (26149)
Seq/√Len:	1450.5

ECOLI - GALS GALR PURR ASCG CYTR RBSR LACI MALI GNTR CRA IDNR YCJW EBGR TRER TORT ALSB YTFQ RBSB XYLF YPHF ARAF LSRB DGAL XYLR
BACSU - KDGR CCPA RBSR NTDR DEGA EXUR YKVZ MSMR GANR YVDE ARAR CCPB RBSB

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
176_H	239_T	3.651	1.00
161_L	200_S	3.555	1.00
10_Q	42_E	3.273	1.00
262_A	265_L	3.135	1.00
167_A	270_I	2.680	1.00
274_D	289_R	2.677	1.00
154_R	306_G	2.553	1.00
176_H	268_S	2.510	1.00
118_A	303_A	2.509	1.00
195_K	199_M	2.436	1.00
165_R	204_E	2.408	1.00
225_E	258_D	2.289	1.00
84_V	87_Q	2.241	1.00
84_V	301_E	2.230	1.00
38_K	42_E	2.223	1.00
34_E	38_K	2.222	1.00
30_A	34_E	2.203	1.00
298_L	301_E	2.141	1.00
169_R	173_N	2.108	1.00
174_N	329_V	2.096	1.00
80_A	296_A	2.086	1.00
224_G	251_G	2.082	1.00
165_R	200_S	2.059	1.00
233_G	259_N	2.054	1.00
164_A	168_T	2.030	1.00
172_L	205_Q	2.010	1.00
163_G	272_F	2.003	1.00
229_V	259_N	1.988	1.00
256_L	267_L	1.947	1.00
85_A	300_T	1.943	1.00
33_R	37_M	1.939	1.00
305_Q	310_N	1.926	1.00
165_R	201_A	1.924	1.00
21_V	36_V	1.882	1.00
162_S	166_M	1.867	1.00
22_L	40_V	1.861	1.00
161_L	196_A	1.846	1.00
169_R	201_A	1.802	1.00
83_L	293_A	1.800	1.00
164_A	242_F	1.771	1.00
229_V	255_A	1.741	1.00
5_R	15_V	1.729	1.00
289_R	322_T	1.721	1.00
165_R	169_R	1.702	1.00
171_L	240_A	1.681	1.00
169_R	205_Q	1.679	1.00
261_I	266_H	1.679	1.00
225_E	255_A	1.671	1.00
228_M	241_V	1.668	1.00
63_G	116_C	1.635	1.00
228_M	252_A	1.628	1.00
84_V	297_K	1.625	1.00
11_A	39_A	1.618	1.00
291_P	294_S	1.597	1.00
262_A	266_H	1.593	1.00
80_A	293_A	1.591	1.00
274_D	326_R	1.588	1.00
166_M	321_P	1.588	1.00
168_T	198_W	1.570	1.00
159_D	162_S	1.555	1.00
284_Q	327_H	1.543	1.00
181_Y	244_Y	1.523	1.00
196_A	200_S	1.512	1.00
180_G	238_L	1.496	1.00
37_M	41_S	1.496	1.00
298_L	317_H	1.493	1.00
243_A	252_A	1.491	1.00
10_Q	39_A	1.490	1.00
178_R	210_P	1.486	1.00
178_R	237_Q	1.474	1.00
168_T	172_L	1.467	1.00
84_V	300_T	1.447	1.00
172_L	201_A	1.432	1.00
162_S	165_R	1.428	1.00
144_I	299_A	1.426	1.00
168_T	197_G	1.424	1.00
21_V	40_V	1.422	1.00
229_V	258_D	1.413	1.00
7_V	39_A	1.409	1.00
37_M	40_V	1.406	1.00
170_M	174_N	1.400	1.00
164_A	197_G	1.399	1.00
257_K	282_D	1.393	1.00
255_A	259_N	1.391	1.00
193_M	196_A	1.385	1.00
294_S	298_L	1.381	1.00
163_G	321_P	1.375	1.00
294_S	297_K	1.373	1.00
270_I	286_T	1.358	1.00
132_A	136_D	1.357	1.00
7_V	11_A	1.353	1.00
301_E	305_Q	1.351	1.00
215_G	230_E	1.347	1.00
84_V	88_H	1.347	1.00
199_M	203_K	1.346	1.00
88_H	304_L	1.343	1.00
176_H	240_A	1.341	1.00
60_D	117_N	1.331	1.00
180_G	231_L	1.328	1.00
170_M	173_N	1.310	1.00
63_G	111_L	1.306	1.00
256_L	261_I	1.306	1.00
168_T	201_A	1.300	1.00
95_G	111_L	1.289	1.00
170_M	329_V	1.284	1.00
255_A	258_D	1.281	1.00
62_I	85_A	1.273	1.00
210_P	213_W	1.268	1.00
60_D	90_K	1.266	1.00
225_E	254_T	1.264	1.00
218_T	223_G	1.249	1.00
6_D	9_R	1.249	1.00
29_S	32_T	1.244	1.00
235_N	238_L	1.242	1.00
225_E	229_V	1.235	1.00
197_G	201_A	1.229	1.00
228_M	256_L	1.228	1.00
178_R	239_T	1.226	1.00
20_R	25_S	1.220	1.00
169_R	204_E	1.219	1.00
170_M	325_R	1.211	1.00
246_D	287_T	1.211	1.00
4_I	18_V	1.203	1.00
39_A	43_L	1.201	1.00
182_L	252_A	1.198	1.00
30_A	33_R	1.196	1.00
5_R	9_R	1.190	1.00
81_V	300_T	1.186	1.00
109_E	133_Q	1.178	1.00
81_V	120_I	1.175	1.00
64_V	81_V	1.173	1.00
198_W	202_L	1.172	1.00
268_S	329_V	1.172	1.00
230_E	234_R	1.168	1.00
241_V	252_A	1.167	1.00
85_A	92_V	1.165	1.00
10_Q	43_L	1.161	1.00
120_I	299_A	1.156	1.00
229_V	233_G	1.154	1.00
253_L	269_I	1.151	1.00
7_V	43_L	1.146	1.00
201_A	204_E	1.142	1.00
304_L	308_A	1.142	1.00
251_G	255_A	1.138	1.00
161_L	193_M	1.136	1.00
222_P	226_A	1.134	1.00
95_G	107_A	1.133	1.00
173_N	205_Q	1.129	1.00
161_L	165_R	1.127	1.00
48_N	54_L	1.121	1.00
166_M	169_R	1.120	1.00
179_I	202_L	1.106	1.00
226_A	230_E	1.105	1.00
48_N	51_A	1.101	1.00
246_D	271_G	1.093	1.00
4_I	15_V	1.088	1.00
293_A	297_K	1.084	1.00
172_L	207_I	1.083	1.00
35_A	39_A	1.082	1.00
174_N	325_R	1.073	1.00
200_S	204_E	1.072	1.00
39_A	42_E	1.072	1.00
64_V	92_V	1.066	1.00
21_V	28_V	1.062	1.00
224_G	228_M	1.059	1.00
82_D	86_Q	1.059	1.00
38_K	41_S	1.056	1.00
161_L	197_G	1.046	1.00
167_A	242_F	1.046	1.00
177_Q	239_T	1.042	1.00
32_T	35_A	1.036	1.00
220_D	223_G	1.024	1.00
184_S	219_P	1.022	1.00
302_L	317_H	1.020	1.00
88_H	301_E	1.016	1.00
181_Y	195_K	1.015	1.00
178_R	236_L	1.007	1.00
88_H	308_A	1.002	1.00
296_A	300_T	0.998	1.00
158_L	291_P	0.998	1.00
198_W	242_F	0.993	1.00
187_G	192_A	0.992	1.00
50_N	53_A	0.991	1.00
40_V	43_L	0.990	1.00
298_L	302_L	0.984	1.00
83_L	297_K	0.976	1.00
24_N	33_R	0.971	1.00
174_N	268_S	0.970	1.00
253_L	281_T	0.965	1.00
243_A	249_A	0.965	1.00
34_E	37_M	0.963	1.00
105_R	109_E	0.961	1.00
87_Q	297_K	0.955	1.00
215_G	227_A	0.954	1.00
167_A	288_V	0.953	1.00
159_D	318_C	0.949	1.00
64_V	78_V	0.948	1.00
61_T	91_Y	0.947	1.00
243_A	248_M	0.946	1.00
298_L	319_F	0.943	1.00
253_L	263_I	0.941	1.00
61_T	93_L	0.940	1.00
86_Q	103_K	0.938	1.00
297_K	301_E	0.929	1.00
291_P	319_F	0.922	1.00
303_A	307_A	0.919	1.00
179_I	240_A	0.918	1.00
51_A	54_L	0.917	1.00
271_G	287_T	0.917	1.00
228_M	232_L	0.914	1.00
103_K	106_H	0.913	1.00
196_A	199_M	0.913	1.00
11_A	18_V	0.912	1.00
217_G	248_M	0.910	1.00
90_K	304_L	0.908	1.00
202_L	207_I	0.904	1.00
59_S	117_N	0.896	1.00
246_D	274_D	0.895	1.00
120_I	303_A	0.891	1.00
109_E	113_R	0.891	1.00
192_A	196_A	0.887	1.00
273_D	290_Y	0.887	1.00
227_A	230_E	0.884	1.00
47_P	52_Q	0.884	1.00
17_T	20_R	0.883	1.00
186_H	216_A	0.881	1.00
178_R	213_W	0.879	1.00
201_A	205_Q	0.878	1.00
274_D	278_A	0.875	1.00
232_L	255_A	0.873	1.00
199_M	209_P	0.867	1.00
158_L	290_Y	0.864	1.00
223_G	226_A	0.863	1.00
168_T	202_L	0.860	1.00
76_A	293_A	0.859	1.00
62_I	120_I	0.858	1.00
170_M	286_T	0.856	1.00
162_S	321_P	0.853	1.00
31_D	34_E	0.853	1.00
162_S	320_M	0.852	1.00
322_T	325_R	0.847	1.00
159_D	320_M	0.840	1.00
81_V	296_A	0.837	1.00
226_A	229_V	0.836	1.00
256_L	269_I	0.836	1.00
81_V	92_V	0.834	1.00
289_R	324_V	0.833	1.00
221_M	254_T	0.833	1.00
155_C	316_S	0.832	1.00
172_L	177_Q	0.826	1.00
325_R	329_V	0.825	1.00
156_V	302_L	0.823	1.00
274_D	324_V	0.821	1.00
261_I	267_L	0.819	1.00
202_L	209_P	0.813	1.00
79_K	83_L	0.811	1.00
180_G	241_V	0.809	1.00
239_T	268_S	0.806	1.00
73_F	292_I	0.805	1.00
246_D	249_A	0.803	1.00
21_V	37_M	0.802	1.00
234_R	238_L	0.800	1.00
278_A	281_T	0.799	1.00
112_I	137_N	0.799	1.00
80_A	297_K	0.799	1.00
200_S	203_K	0.799	1.00
286_T	329_V	0.798	1.00
158_L	321_P	0.796	1.00
100_E	103_K	0.793	1.00
250_A	281_T	0.792	1.00
160_N	194_R	0.791	1.00
46_R	113_R	0.784	1.00
24_N	37_M	0.784	1.00
237_Q	261_I	0.782	1.00
213_W	234_R	0.781	1.00
277_I	281_T	0.781	1.00
181_Y	242_F	0.778	1.00
189_E	193_M	0.777	1.00
67_M	74_F	0.777	1.00
133_Q	136_D	0.773	1.00
223_G	227_A	0.771	1.00
170_M	323_L	0.770	1.00
106_H	109_E	0.768	1.00
58_V	117_N	0.763	1.00
309_G	312_D	0.762	1.00
195_K	214_I	0.762	1.00
134_F	141_M	0.759	1.00
20_R	26_T	0.759	1.00
157_C	318_C	0.759	1.00
154_R	315_A	0.759	1.00
171_L	270_I	0.757	1.00
193_M	197_G	0.757	1.00
182_L	243_A	0.756	1.00
49_A	52_Q	0.756	1.00
234_R	237_Q	0.753	1.00
291_P	322_T	0.752	1.00
257_K	284_Q	0.747	1.00
300_T	304_L	0.745	1.00
20_R	27_L	0.741	1.00
232_L	259_N	0.737	1.00
241_V	267_L	0.736	1.00
77_L	144_I	0.736	1.00
228_M	231_L	0.732	1.00
83_L	87_Q	0.731	1.00
302_L	305_Q	0.730	1.00
154_R	302_L	0.727	1.00
177_Q	207_I	0.725	1.00
165_R	197_G	0.724	1.00
209_P	212_S	0.723	1.00
58_V	308_A	0.721	1.00
215_G	231_L	0.717	1.00
63_G	119_L	0.714	1.00
118_A	307_A	0.713	1.00
166_M	288_V	0.713	1.00
98_Y	103_K	0.712	1.00
286_T	323_L	0.711	1.00
34_E	41_S	0.709	1.00
228_M	251_G	0.709	1.00
13_V	36_V	0.707	1.00
62_I	300_T	0.706	1.00
61_T	114_Q	0.705	1.00
242_F	270_I	0.702	1.00
209_P	214_I	0.701	1.00
179_I	198_W	0.698	1.00
5_R	55_A	0.698	1.00
16_A	20_R	0.698	1.00
112_I	139_P	0.697	1.00
103_K	107_A	0.694	1.00
178_R	208_I	0.694	1.00
145_N	160_N	0.692	1.00
230_E	233_G	0.691	1.00
31_D	35_A	0.691	1.00
228_M	255_A	0.691	1.00
293_A	296_A	0.689	1.00
143_L	148_V	0.688	1.00
270_I	329_V	0.682	1.00
118_A	142_V	0.682	1.00
79_K	82_D	0.681	1.00
183_S	195_K	0.681	1.00
80_A	84_V	0.680	1.00
305_Q	309_G	0.680	1.00
224_G	227_A	0.679	1.00
245_N	273_D	0.678	1.00
102_E	106_H	0.678	1.00
286_T	325_R	0.678	1.00
82_D	92_V	0.675	1.00
217_G	223_G	0.675	1.00
46_R	109_E	0.674	1.00
27_L	32_T	0.670	1.00
80_A	292_I	0.667	1.00
18_V	36_V	0.667	1.00
145_N	190_D	0.665	1.00
7_V	18_V	0.664	1.00
172_L	202_L	0.664	1.00
179_I	239_T	0.661	1.00
78_V	94_I	0.660	1.00
120_I	144_I	0.660	1.00
78_V	82_D	0.659	1.00
41_S	44_D	0.658	1.00
82_D	96_N	0.653	1.00
254_T	257_K	0.653	1.00
171_L	242_F	0.651	1.00
305_Q	315_A	0.648	1.00
249_A	271_G	0.648	1.00
157_C	316_S	0.645	1.00
71_D	247_N	0.644	1.00
180_G	213_W	0.643	1.00
256_L	259_N	0.639	1.00
167_A	240_A	0.639	1.00
135_M	152_A	0.639	1.00
147_V	316_S	0.637	1.00
295_M	319_F	0.636	1.00
77_L	292_I	0.634	1.00
65_V	107_A	0.632	1.00
198_W	209_P	0.632	1.00
93_L	116_C	0.631	1.00
132_A	135_M	0.629	1.00
219_P	244_Y	0.628	1.00
108_I	119_L	0.627	1.00
160_N	193_M	0.626	1.00
21_V	33_R	0.624	1.00
284_Q	326_R	0.624	1.00
250_A	275_I	0.619	1.00
143_L	153_H	0.619	1.00
18_V	21_V	0.618	1.00
184_S	191_D	0.618	1.00
90_K	117_N	0.617	1.00
254_T	284_Q	0.617	1.00
191_D	219_P	0.616	1.00
118_A	299_A	0.616	1.00
62_I	90_K	0.615	1.00
194_R	290_Y	0.612	1.00
44_D	47_P	0.608	1.00
35_A	38_K	0.606	1.00
165_R	168_T	0.603	1.00
238_L	261_I	0.602	1.00
254_T	258_D	0.600	1.00
18_V	40_V	0.600	1.00
90_K	307_A	0.598	1.00
272_F	290_Y	0.595	1.00
219_P	248_M	0.593	1.00
225_E	251_G	0.593	1.00
181_Y	198_W	0.590	1.00
242_F	272_F	0.590	1.00
79_K	293_A	0.590	1.00
79_K	98_Y	0.589	1.00
116_C	119_L	0.585	1.00
178_R	238_L	0.585	1.00
166_M	170_M	0.584	1.00
256_L	263_I	0.583	1.00
135_M	141_M	0.582	1.00
142_V	302_L	0.582	1.00
129_D	132_A	0.582	1.00
73_F	77_L	0.579	1.00
85_A	304_L	0.577	1.00
257_K	262_A	0.577	1.00
25_S	28_V	0.574	1.00
275_I	287_T	0.573	1.00
97_S	104_E	0.573	1.00
222_P	225_E	0.570	1.00
258_D	282_D	0.567	1.00
278_A	287_T	0.567	1.00
221_M	251_G	0.566	1.00
130_E	133_Q	0.565	1.00
215_G	234_R	0.564	1.00
62_I	118_A	0.564	1.00
243_A	271_G	0.562	1.00
13_V	18_V	0.561	1.00
158_L	163_G	0.561	1.00
142_V	156_V	0.561	1.00
46_R	50_N	0.557	1.00
20_R	28_V	0.554	1.00
71_D	74_F	0.553	1.00
283_P	328_S	0.551	1.00
62_I	307_A	0.551	1.00
217_G	224_G	0.551	1.00
199_M	211_E	0.548	1.00
302_L	306_G	0.547	1.00
11_A	36_V	0.547	1.00
274_D	279_R	0.547	1.00
142_V	299_A	0.546	1.00
142_V	303_A	0.546	1.00
227_A	231_L	0.545	1.00
191_D	244_Y	0.544	1.00
306_G	309_G	0.544	1.00
245_N	248_M	0.542	1.00
76_A	292_I	0.541	1.00
142_V	306_G	0.538	1.00
174_N	239_T	0.538	1.00
52_Q	56_T	0.538	1.00
240_A	268_S	0.537	1.00
232_L	256_L	0.537	1.00
135_M	153_H	0.535	1.00
183_S	216_A	0.535	1.00
156_V	298_L	0.534	1.00
99_H	146_R	0.532	1.00
53_A	56_T	0.530	1.00
72_A	247_N	0.529	1.00
253_L	257_K	0.529	1.00
168_T	242_F	0.528	1.00
11_A	21_V	0.527	1.00
306_G	312_D	0.527	1.00
141_M	153_H	0.526	1.00
84_V	304_L	0.526	1.00
223_G	248_M	0.525	1.00
283_P	327_H	0.525	1.00
93_L	114_Q	0.525	1.00
195_K	216_A	0.525	1.00
278_A	285_L	0.523	1.00
254_T	282_D	0.522	1.00
13_V	32_T	0.521	1.00
105_R	130_E	0.521	1.00
167_A	198_W	0.521	1.00
24_N	27_L	0.517	1.00
59_S	90_K	0.513	1.00
158_L	272_F	0.512	1.00
26_T	33_R	0.509	1.00
121_V	143_L	0.508	1.00
111_L	116_C	0.508	1.00
76_A	276_P	0.507	1.00
119_L	139_P	0.505	1.00
104_E	123_S	0.504	1.00
183_S	214_I	0.503	1.00
224_G	248_M	0.501	1.00
25_S	33_R	0.501	1.00
281_T	284_Q	0.500	1.00
21_V	27_L	0.500	1.00
63_G	95_G	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3dbiA	2	0.7977	100	0.088	Contact Map
2hsgA	1	0.9451	100	0.09	Contact Map
1qpzA	2	0.974	100	0.095	Contact Map
2o20A	2	0.7948	100	0.096	Contact Map
3bilA	2	0.7399	100	0.102	Contact Map
4o5aA	2	0.7775	100	0.103	Contact Map
3e3mA	2	0.7746	100	0.104	Contact Map
3kjxA	2	0.9566	100	0.106	Contact Map
3ctpA	2	0.7659	100	0.107	Contact Map
3h5oA	2	0.7803	100	0.112	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0109 seconds.