GREMLIN Database
HFLD - High frequency lysogenization protein HflD
UniProt: P25746 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11345
Length: 213 (200)
Sequences: 505 (349)
Seq/√Len: 24.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
92_L174_G5.8061.00
55_F177_A4.9391.00
14_G177_A4.9141.00
25_L163_V4.0101.00
112_R140_D3.2101.00
19_A174_G3.2001.00
14_G39_S3.1871.00
15_I93_M2.8921.00
105_A141_V2.8140.99
112_R137_I2.7860.99
136_A140_D2.7050.99
141_V144_P2.5700.99
50_S53_A2.5150.99
39_S55_F2.2490.97
40_L169_A2.1790.97
96_E182_H2.1630.97
45_D53_A2.1120.96
25_L170_T2.0950.96
49_S53_A2.0770.96
7_D51_T2.0290.95
9_T201_Q2.0290.95
112_R150_Q1.9350.94
46_M113_I1.8930.93
142_I175_I1.8660.92
156_A159_Q1.8140.91
106_L109_L1.7960.91
99_L109_L1.7940.91
14_G54_V1.7600.90
187_G190_Q1.7560.90
23_Q84_E1.6980.88
110_G114_N1.6530.87
40_L134_M1.5840.84
27_H84_E1.5600.83
157_V192_M1.5460.83
128_E162_Q1.5250.82
64_V68_T1.5230.82
120_L130_L1.5140.82
40_L116_L1.4970.81
8_I147_P1.4910.80
45_D48_P1.4910.80
19_A92_L1.4780.80
128_E175_I1.4720.80
66_L205_I1.4710.80
51_T184_V1.4160.77
137_I140_D1.4100.77
102_A105_A1.4100.77
105_A142_I1.3920.76
8_I198_L1.3850.75
17_Q65_G1.3790.75
37_H41_N1.3410.73
35_A39_S1.3230.72
163_V170_T1.3190.72
42_S177_A1.2710.69
155_P159_Q1.2430.67
92_L175_I1.2430.67
157_V163_V1.2290.66
8_I90_L1.2290.66
148_R151_V1.2280.66
129_T154_S1.2270.66
14_G87_R1.2210.65
83_A91_S1.1960.64
120_L124_D1.1950.64
22_V151_V1.1880.63
91_S193_F1.1830.63
27_H86_T1.1770.63
88_Y149_I1.1720.62
23_Q82_N1.1640.62
162_Q166_K1.1580.61
16_C164_Q1.1410.60
113_I147_P1.1400.60
100_S182_H1.1330.60
132_S136_A1.1320.59
58_S205_I1.1290.59
91_S149_I1.1260.59
115_G190_Q1.1230.59
9_T32_D1.1050.58
140_D150_Q1.0760.56
133_A136_A1.0700.55
72_V82_N1.0530.54
132_S165_A1.0500.54
165_A197_R1.0440.53
48_P183_Q1.0430.53
6_Y204_Q1.0370.53
74_N137_I1.0290.52
179_V202_A1.0280.52
9_T202_A1.0250.52
18_S132_S1.0230.52
105_A144_P1.0200.52
27_H166_K1.0100.51
175_I202_A1.0010.50
13_A17_Q0.9990.50
9_T198_L0.9990.50
43_I134_M0.9950.50
55_F105_A0.9900.49
116_L121_E0.9900.49
116_L130_L0.9700.48
8_I190_Q0.9700.48
25_L31_C0.9690.48
63_R67_E0.9630.47
99_L106_L0.9600.47
19_A151_V0.9550.47
112_R136_A0.9540.47
107_D111_N0.9520.47
23_Q179_V0.9440.46
106_L110_G0.9370.46
38_V56_G0.9360.45
107_D167_V0.9340.45
196_N200_T0.9310.45
55_F87_R0.9280.45
115_G118_R0.9270.45
136_A150_Q0.9250.45
89_T175_I0.9250.45
43_I113_I0.9150.44
112_R190_Q0.9090.44
13_A135_A0.9050.43
16_C191_L0.8960.43
70_L202_A0.8900.42
64_V187_G0.8840.42
17_Q21_L0.8820.42
69_L175_I0.8770.41
43_I46_M0.8760.41
7_D55_F0.8750.41
39_S64_V0.8670.41
89_T189_L0.8670.41
157_V191_L0.8650.40
199_T202_A0.8640.40
21_L98_K0.8610.40
57_G61_N0.8610.40
40_L120_L0.8530.40
96_E179_V0.8510.40
12_L90_L0.8460.39
90_L133_A0.8450.39
142_I147_P0.8430.39
16_C154_S0.8390.39
97_R188_R0.8360.38
95_L123_F0.8320.38
169_A173_A0.8300.38
196_N199_T0.8300.38
9_T67_E0.8260.38
163_V174_G0.8210.37
16_C89_T0.8200.37
48_P54_V0.8190.37
4_N184_V0.8180.37
108_T111_N0.8140.37
179_V183_Q0.8090.37
116_L133_A0.8070.37
21_L39_S0.8070.37
121_E124_D0.8060.36
119_Q129_T0.7980.36
72_V86_T0.7970.36
37_H124_D0.7910.35
62_L202_A0.7890.35
51_T56_G0.7830.35
18_S21_L0.7810.35
112_R147_P0.7780.35
93_M160_S0.7750.34
47_N173_A0.7750.34
4_N10_L0.7720.34
14_G18_S0.7720.34
104_G111_N0.7710.34
72_V90_L0.7670.34
70_L142_I0.7590.33
140_D178_A0.7580.33
135_A152_T0.7570.33
98_K132_S0.7560.33
52_L57_G0.7530.33
41_N124_D0.7480.33
21_L169_A0.7390.32
124_D187_G0.7380.32
114_N162_Q0.7290.31
7_D184_V0.7270.31
36_L126_Q0.7250.31
56_G91_S0.7240.31
160_S182_H0.7240.31
141_V189_L0.7200.31
21_L151_V0.7190.31
31_C75_A0.7140.31
96_E145_L0.7120.30
120_L125_L0.7080.30
119_Q123_F0.7050.30
176_R180_L0.7040.30
18_S167_V0.7030.30
48_P110_G0.7030.30
24_Q98_K0.7030.30
20_R24_Q0.6980.30
163_V166_K0.6960.29
46_M164_Q0.6930.29
41_N45_D0.6910.29
24_Q39_S0.6910.29
141_V164_Q0.6890.29
98_K159_Q0.6890.29
139_V164_Q0.6880.29
28_Q47_N0.6870.29
123_F129_T0.6870.29
7_D111_N0.6830.29
11_A169_A0.6800.29
150_Q179_V0.6780.28
160_S166_K0.6730.28
10_L66_L0.6710.28
53_A66_L0.6680.28
77_S122_H0.6630.28
88_Y188_R0.6620.27
85_L205_I0.6610.27
142_I146_G0.6550.27
42_S192_M0.6460.27
5_Y8_I0.6410.26
82_N179_V0.6410.26
21_L174_G0.6360.26
16_C74_N0.6350.26
36_L39_S0.6350.26
133_A151_V0.6320.26
99_L123_F0.6300.26
13_A66_L0.6280.26
18_S151_V0.6270.26
96_E147_P0.6230.25
4_N111_N0.6170.25
48_P128_E0.6150.25
159_Q187_G0.6150.25
16_C85_L0.6140.25
92_L135_A0.6130.25
129_T132_S0.6120.25
135_A202_A0.6090.25
34_D54_V0.6080.25
52_L58_S0.6030.24
143_S171_L0.6020.24
105_A120_L0.6000.24
94_V128_E0.5960.24
146_G164_Q0.5950.24
98_K173_A0.5930.24
128_E159_Q0.5920.24
69_L74_N0.5900.24
14_G46_M0.5900.24
30_H196_N0.5890.24
15_I47_N0.5870.23
18_S192_M0.5870.23
164_Q189_L0.5860.23
34_D142_I0.5840.23
18_S127_S0.5840.23
101_S149_I0.5830.23
119_Q194_S0.5790.23
16_C144_P0.5740.23
10_L111_N0.5730.23
95_L142_I0.5680.22
100_S173_A0.5670.22
44_I116_L0.5670.22
57_G152_T0.5660.22
91_S107_D0.5630.22
57_G124_D0.5620.22
88_Y99_L0.5610.22
8_I194_S0.5580.22
74_N85_L0.5580.22
141_V148_R0.5520.22
56_G143_S0.5510.22
107_D162_Q0.5510.22
99_L135_A0.5500.22
97_R178_A0.5500.22
28_Q77_S0.5490.21
103_K107_D0.5470.21
156_A191_L0.5470.21
22_V176_R0.5460.21
127_S182_H0.5430.21
35_A64_V0.5410.21
41_N192_M0.5390.21
44_I149_I0.5390.21
117_Q167_V0.5380.21
73_L97_R0.5380.21
40_L133_A0.5360.21
147_P150_Q0.5360.21
86_T144_P0.5350.21
105_A146_G0.5350.21
98_K191_L0.5330.21
24_Q64_V0.5320.21
51_T55_F0.5320.21
52_L71_G0.5320.21
106_L188_R0.5320.21
118_R129_T0.5300.21
84_E142_I0.5280.20
63_R77_S0.5270.20
160_S197_R0.5260.20
132_S167_V0.5220.20
194_S197_R0.5220.20
52_L56_G0.5210.20
120_L155_P0.5180.20
11_A18_S0.5180.20
55_F173_A0.5170.20
179_V182_H0.5160.20
67_E137_I0.5160.20
167_V204_Q0.5160.20
88_Y98_K0.5130.20
145_L173_A0.5130.20
21_L166_K0.5110.20
8_I154_S0.5080.20
151_V167_V0.5070.20
5_Y137_I0.5070.20
109_L118_R0.5050.19
167_V194_S0.5050.19
58_S61_N0.5030.19
54_V183_Q0.5030.19
75_A131_M0.5020.19
40_L125_L0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1sdiA 1 1 100 0.034 Contact Map
1o20A 3 0.23 15.3 0.965 Contact Map
4cgcA 3 0.1362 8.1 0.969 Contact Map
2hz7A 1 0 6.6 0.97 Contact Map
2w96A 1 0.338 6.2 0.971 Contact Map
4i16A 1 0.2535 5.5 0.971 Contact Map
1zl8A 1 0.2441 5.4 0.972 Contact Map
4qhpA 1 0.6103 5.2 0.972 Contact Map
2rnnA 1 0.2958 5 0.972 Contact Map
4cpgA 2 0.2911 4.9 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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