HFLD - ECOLI - GREMLIN Contacts

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HFLD - High frequency lysogenization protein HflD

UniProt:	P25746	Sequences: MAKNYYDITLALAGICQSARLVQQLAHQGHCDADALHVSLNSIIDMNPSSTLAVFGGSEANLRVGLETLLGVLNASSRQGLNAELTRYTLSLMVLERKLSSAKGALDTLGNRINGLQRQLEHFDLQSETLMSAMAAIYVDVISPLGPRIQVTGSPAVLQSPQVQAKVRATLLAGIRAAVLWHQVGGGRLQLMFSRNRLTTQAKQILAHLTPEL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11345
Length:	213 (200)
Sequences:	505 (349)
Seq/√Len:	24.7

ECOLI - HFLD

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
92_L	174_G	5.806	1.00
55_F	177_A	4.939	1.00
14_G	177_A	4.914	1.00
25_L	163_V	4.010	1.00
112_R	140_D	3.210	1.00
19_A	174_G	3.200	1.00
14_G	39_S	3.187	1.00
15_I	93_M	2.892	1.00
105_A	141_V	2.814	0.99
112_R	137_I	2.786	0.99
136_A	140_D	2.705	0.99
141_V	144_P	2.570	0.99
50_S	53_A	2.515	0.99
39_S	55_F	2.249	0.97
40_L	169_A	2.179	0.97
96_E	182_H	2.163	0.97
45_D	53_A	2.112	0.96
25_L	170_T	2.095	0.96
49_S	53_A	2.077	0.96
7_D	51_T	2.029	0.95
9_T	201_Q	2.029	0.95
112_R	150_Q	1.935	0.94
46_M	113_I	1.893	0.93
142_I	175_I	1.866	0.92
156_A	159_Q	1.814	0.91
106_L	109_L	1.796	0.91
99_L	109_L	1.794	0.91
14_G	54_V	1.760	0.90
187_G	190_Q	1.756	0.90
23_Q	84_E	1.698	0.88
110_G	114_N	1.653	0.87
40_L	134_M	1.584	0.84
27_H	84_E	1.560	0.83
157_V	192_M	1.546	0.83
128_E	162_Q	1.525	0.82
64_V	68_T	1.523	0.82
120_L	130_L	1.514	0.82
40_L	116_L	1.497	0.81
8_I	147_P	1.491	0.80
45_D	48_P	1.491	0.80
19_A	92_L	1.478	0.80
128_E	175_I	1.472	0.80
66_L	205_I	1.471	0.80
51_T	184_V	1.416	0.77
137_I	140_D	1.410	0.77
102_A	105_A	1.410	0.77
105_A	142_I	1.392	0.76
8_I	198_L	1.385	0.75
17_Q	65_G	1.379	0.75
37_H	41_N	1.341	0.73
35_A	39_S	1.323	0.72
163_V	170_T	1.319	0.72
42_S	177_A	1.271	0.69
155_P	159_Q	1.243	0.67
92_L	175_I	1.243	0.67
157_V	163_V	1.229	0.66
8_I	90_L	1.229	0.66
148_R	151_V	1.228	0.66
129_T	154_S	1.227	0.66
14_G	87_R	1.221	0.65
83_A	91_S	1.196	0.64
120_L	124_D	1.195	0.64
22_V	151_V	1.188	0.63
91_S	193_F	1.183	0.63
27_H	86_T	1.177	0.63
88_Y	149_I	1.172	0.62
23_Q	82_N	1.164	0.62
162_Q	166_K	1.158	0.61
16_C	164_Q	1.141	0.60
113_I	147_P	1.140	0.60
100_S	182_H	1.133	0.60
132_S	136_A	1.132	0.59
58_S	205_I	1.129	0.59
91_S	149_I	1.126	0.59
115_G	190_Q	1.123	0.59
9_T	32_D	1.105	0.58
140_D	150_Q	1.076	0.56
133_A	136_A	1.070	0.55
72_V	82_N	1.053	0.54
132_S	165_A	1.050	0.54
165_A	197_R	1.044	0.53
48_P	183_Q	1.043	0.53
6_Y	204_Q	1.037	0.53
74_N	137_I	1.029	0.52
179_V	202_A	1.028	0.52
9_T	202_A	1.025	0.52
18_S	132_S	1.023	0.52
105_A	144_P	1.020	0.52
27_H	166_K	1.010	0.51
175_I	202_A	1.001	0.50
13_A	17_Q	0.999	0.50
9_T	198_L	0.999	0.50
43_I	134_M	0.995	0.50
55_F	105_A	0.990	0.49
116_L	121_E	0.990	0.49
116_L	130_L	0.970	0.48
8_I	190_Q	0.970	0.48
25_L	31_C	0.969	0.48
63_R	67_E	0.963	0.47
99_L	106_L	0.960	0.47
19_A	151_V	0.955	0.47
112_R	136_A	0.954	0.47
107_D	111_N	0.952	0.47
23_Q	179_V	0.944	0.46
106_L	110_G	0.937	0.46
38_V	56_G	0.936	0.45
107_D	167_V	0.934	0.45
196_N	200_T	0.931	0.45
55_F	87_R	0.928	0.45
115_G	118_R	0.927	0.45
136_A	150_Q	0.925	0.45
89_T	175_I	0.925	0.45
43_I	113_I	0.915	0.44
112_R	190_Q	0.909	0.44
13_A	135_A	0.905	0.43
16_C	191_L	0.896	0.43
70_L	202_A	0.890	0.42
64_V	187_G	0.884	0.42
17_Q	21_L	0.882	0.42
69_L	175_I	0.877	0.41
43_I	46_M	0.876	0.41
7_D	55_F	0.875	0.41
39_S	64_V	0.867	0.41
89_T	189_L	0.867	0.41
157_V	191_L	0.865	0.40
199_T	202_A	0.864	0.40
21_L	98_K	0.861	0.40
57_G	61_N	0.861	0.40
40_L	120_L	0.853	0.40
96_E	179_V	0.851	0.40
12_L	90_L	0.846	0.39
90_L	133_A	0.845	0.39
142_I	147_P	0.843	0.39
16_C	154_S	0.839	0.39
97_R	188_R	0.836	0.38
95_L	123_F	0.832	0.38
169_A	173_A	0.830	0.38
196_N	199_T	0.830	0.38
9_T	67_E	0.826	0.38
163_V	174_G	0.821	0.37
16_C	89_T	0.820	0.37
48_P	54_V	0.819	0.37
4_N	184_V	0.818	0.37
108_T	111_N	0.814	0.37
179_V	183_Q	0.809	0.37
116_L	133_A	0.807	0.37
21_L	39_S	0.807	0.37
121_E	124_D	0.806	0.36
119_Q	129_T	0.798	0.36
72_V	86_T	0.797	0.36
37_H	124_D	0.791	0.35
62_L	202_A	0.789	0.35
51_T	56_G	0.783	0.35
18_S	21_L	0.781	0.35
112_R	147_P	0.778	0.35
93_M	160_S	0.775	0.34
47_N	173_A	0.775	0.34
4_N	10_L	0.772	0.34
14_G	18_S	0.772	0.34
104_G	111_N	0.771	0.34
72_V	90_L	0.767	0.34
70_L	142_I	0.759	0.33
140_D	178_A	0.758	0.33
135_A	152_T	0.757	0.33
98_K	132_S	0.756	0.33
52_L	57_G	0.753	0.33
41_N	124_D	0.748	0.33
21_L	169_A	0.739	0.32
124_D	187_G	0.738	0.32
114_N	162_Q	0.729	0.31
7_D	184_V	0.727	0.31
36_L	126_Q	0.725	0.31
56_G	91_S	0.724	0.31
160_S	182_H	0.724	0.31
141_V	189_L	0.720	0.31
21_L	151_V	0.719	0.31
31_C	75_A	0.714	0.31
96_E	145_L	0.712	0.30
120_L	125_L	0.708	0.30
119_Q	123_F	0.705	0.30
176_R	180_L	0.704	0.30
18_S	167_V	0.703	0.30
48_P	110_G	0.703	0.30
24_Q	98_K	0.703	0.30
20_R	24_Q	0.698	0.30
163_V	166_K	0.696	0.29
46_M	164_Q	0.693	0.29
41_N	45_D	0.691	0.29
24_Q	39_S	0.691	0.29
141_V	164_Q	0.689	0.29
98_K	159_Q	0.689	0.29
139_V	164_Q	0.688	0.29
28_Q	47_N	0.687	0.29
123_F	129_T	0.687	0.29
7_D	111_N	0.683	0.29
11_A	169_A	0.680	0.29
150_Q	179_V	0.678	0.28
160_S	166_K	0.673	0.28
10_L	66_L	0.671	0.28
53_A	66_L	0.668	0.28
77_S	122_H	0.663	0.28
88_Y	188_R	0.662	0.27
85_L	205_I	0.661	0.27
142_I	146_G	0.655	0.27
42_S	192_M	0.646	0.27
5_Y	8_I	0.641	0.26
82_N	179_V	0.641	0.26
21_L	174_G	0.636	0.26
16_C	74_N	0.635	0.26
36_L	39_S	0.635	0.26
133_A	151_V	0.632	0.26
99_L	123_F	0.630	0.26
13_A	66_L	0.628	0.26
18_S	151_V	0.627	0.26
96_E	147_P	0.623	0.25
4_N	111_N	0.617	0.25
48_P	128_E	0.615	0.25
159_Q	187_G	0.615	0.25
16_C	85_L	0.614	0.25
92_L	135_A	0.613	0.25
129_T	132_S	0.612	0.25
135_A	202_A	0.609	0.25
34_D	54_V	0.608	0.25
52_L	58_S	0.603	0.24
143_S	171_L	0.602	0.24
105_A	120_L	0.600	0.24
94_V	128_E	0.596	0.24
146_G	164_Q	0.595	0.24
98_K	173_A	0.593	0.24
128_E	159_Q	0.592	0.24
69_L	74_N	0.590	0.24
14_G	46_M	0.590	0.24
30_H	196_N	0.589	0.24
15_I	47_N	0.587	0.23
18_S	192_M	0.587	0.23
164_Q	189_L	0.586	0.23
34_D	142_I	0.584	0.23
18_S	127_S	0.584	0.23
101_S	149_I	0.583	0.23
119_Q	194_S	0.579	0.23
16_C	144_P	0.574	0.23
10_L	111_N	0.573	0.23
95_L	142_I	0.568	0.22
100_S	173_A	0.567	0.22
44_I	116_L	0.567	0.22
57_G	152_T	0.566	0.22
91_S	107_D	0.563	0.22
57_G	124_D	0.562	0.22
88_Y	99_L	0.561	0.22
8_I	194_S	0.558	0.22
74_N	85_L	0.558	0.22
141_V	148_R	0.552	0.22
56_G	143_S	0.551	0.22
107_D	162_Q	0.551	0.22
99_L	135_A	0.550	0.22
97_R	178_A	0.550	0.22
28_Q	77_S	0.549	0.21
103_K	107_D	0.547	0.21
156_A	191_L	0.547	0.21
22_V	176_R	0.546	0.21
127_S	182_H	0.543	0.21
35_A	64_V	0.541	0.21
41_N	192_M	0.539	0.21
44_I	149_I	0.539	0.21
117_Q	167_V	0.538	0.21
73_L	97_R	0.538	0.21
40_L	133_A	0.536	0.21
147_P	150_Q	0.536	0.21
86_T	144_P	0.535	0.21
105_A	146_G	0.535	0.21
98_K	191_L	0.533	0.21
24_Q	64_V	0.532	0.21
51_T	55_F	0.532	0.21
52_L	71_G	0.532	0.21
106_L	188_R	0.532	0.21
118_R	129_T	0.530	0.21
84_E	142_I	0.528	0.20
63_R	77_S	0.527	0.20
160_S	197_R	0.526	0.20
132_S	167_V	0.522	0.20
194_S	197_R	0.522	0.20
52_L	56_G	0.521	0.20
120_L	155_P	0.518	0.20
11_A	18_S	0.518	0.20
55_F	173_A	0.517	0.20
179_V	182_H	0.516	0.20
67_E	137_I	0.516	0.20
167_V	204_Q	0.516	0.20
88_Y	98_K	0.513	0.20
145_L	173_A	0.513	0.20
21_L	166_K	0.511	0.20
8_I	154_S	0.508	0.20
151_V	167_V	0.507	0.20
5_Y	137_I	0.507	0.20
109_L	118_R	0.505	0.19
167_V	194_S	0.505	0.19
58_S	61_N	0.503	0.19
54_V	183_Q	0.503	0.19
75_A	131_M	0.502	0.19
40_L	125_L	0.500	0.19

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1sdiA	1	1	100	0.034	Contact Map
1o20A	3	0.23	15.3	0.965	Contact Map
4cgcA	3	0.1362	8.1	0.969	Contact Map
2hz7A	1	0	6.6	0.97	Contact Map
2w96A	1	0.338	6.2	0.971	Contact Map
4i16A	1	0.2535	5.5	0.971	Contact Map
1zl8A	1	0.2441	5.4	0.972	Contact Map
4qhpA	1	0.6103	5.2	0.972	Contact Map
2rnnA	1	0.2958	5	0.972	Contact Map
4cpgA	2	0.2911	4.9	0.972	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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