GREMLIN Database
YCHE - UPF0056 membrane protein YhcE
UniProt: P25743 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11342
Length: 215 (195)
Sequences: 2519 (1678)
Seq/√Len: 120.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
203_V209_I4.2601.00
39_T42_A3.4451.00
55_A161_A3.2871.00
81_I203_V3.2531.00
58_L133_A3.2071.00
89_T92_M2.9771.00
78_S200_E2.8751.00
165_W169_R2.7401.00
77_D208_G2.5971.00
48_L165_W2.5741.00
15_F159_L2.5631.00
53_S120_V2.3981.00
200_E204_T2.3801.00
57_I125_L2.3541.00
55_A158_A2.2311.00
11_Y156_A2.1661.00
66_D70_Q2.1381.00
179_R182_G2.1111.00
52_L56_I2.0051.00
88_V202_I2.0011.00
51_N161_A1.9921.00
14_F156_A1.9751.00
31_F35_T1.9411.00
15_F163_C1.8611.00
63_F154_F1.8581.00
11_Y155_V1.8061.00
59_W154_F1.7741.00
44_N169_R1.7741.00
54_V161_A1.7501.00
91_A195_M1.7151.00
77_D80_R1.7121.00
93_S98_K1.7041.00
207_K210_F1.6941.00
55_A59_W1.6901.00
22_V160_F1.6771.00
53_S124_A1.6431.00
173_W176_R1.6151.00
85_I88_V1.6051.00
23_N26_G1.6011.00
141_G150_L1.5621.00
58_L129_A1.5251.00
80_R204_T1.5081.00
18_L137_T1.5001.00
81_I209_I1.4961.00
57_I129_A1.4801.00
14_F140_W1.4741.00
85_I202_I1.4711.00
31_F47_N1.4441.00
88_V198_G1.4021.00
58_L137_T1.3991.00
141_G153_F1.3721.00
48_L169_R1.3591.00
59_W158_A1.3401.00
40_A44_N1.3131.00
78_S203_V1.3131.00
31_F123_L1.3111.00
62_L137_T1.3051.00
51_N164_C1.3041.00
94_M191_G1.2781.00
11_Y159_L1.2691.00
170_M173_W1.2380.99
43_R172_P1.2320.99
45_K49_T1.2300.99
38_Q42_A1.2220.99
148_S151_F1.2210.99
119_G124_A1.2170.99
128_M164_C1.2080.99
84_G202_I1.2010.99
162_L166_G1.2010.99
137_T157_I1.1970.99
51_N165_W1.1860.99
26_G29_P1.1790.99
38_Q46_T1.1790.99
62_L154_F1.1760.99
11_Y15_F1.1760.99
81_I206_I1.1640.99
203_V206_I1.1560.99
18_L157_I1.1520.99
64_L68_I1.1450.99
80_R208_G1.1330.99
49_T117_S1.1260.99
50_A54_V1.1250.99
22_V161_A1.1210.99
84_G205_G1.1200.99
40_A43_R1.1190.99
20_A72_F1.1140.99
173_W177_V1.1050.99
75_S200_E1.1050.99
56_I60_I1.1010.99
194_L198_G1.0980.99
27_I168_F1.0850.98
62_L141_G1.0850.98
35_T43_R1.0680.98
178_L182_G1.0650.98
94_M190_M1.0520.98
44_N48_L1.0490.98
94_M187_T1.0490.98
20_A23_N1.0390.98
86_L195_M1.0370.98
48_L52_L1.0340.98
57_I124_A1.0310.98
133_A137_T1.0290.98
81_I202_I1.0230.98
29_P32_I1.0220.98
22_V133_A1.0150.98
32_I175_V1.0000.97
85_I92_M0.9950.97
69_L196_A0.9870.97
21_L132_G0.9750.97
86_L90_I0.9710.97
23_N87_V0.9680.97
21_L136_S0.9590.97
54_V124_A0.9530.96
88_V195_M0.9500.96
88_V92_M0.9500.96
195_M198_G0.9480.96
58_L134_I0.9450.96
60_I64_L0.9280.96
62_L150_L0.9270.96
150_L154_F0.9000.95
81_I205_G0.8990.95
151_F155_V0.8970.95
134_I138_I0.8820.95
99_L102_D0.8750.94
166_G170_M0.8690.94
26_G30_V0.8650.94
152_G155_V0.8570.94
162_L173_W0.8550.94
53_S119_G0.8540.94
68_I134_I0.8500.93
40_A172_P0.8450.93
19_F163_C0.8430.93
31_F43_R0.8370.93
188_R199_I0.8310.93
160_F163_C0.8240.92
82_A199_I0.8180.92
111_E115_R0.8160.92
50_A118_I0.8090.92
31_F171_A0.7830.90
87_V139_V0.7810.90
19_F167_L0.7720.90
31_F131_P0.7680.89
51_N54_V0.7640.89
129_A157_I0.7630.89
79_F135_S0.7560.89
79_F161_A0.7530.89
112_T115_R0.7520.88
67_T70_Q0.7510.88
26_G164_C0.7490.88
75_S78_S0.7460.88
17_G136_S0.7450.88
70_Q151_F0.7440.88
81_I199_I0.7410.88
56_I147_I0.7390.88
27_I127_L0.7390.88
86_L183_I0.7370.87
95_I191_G0.7340.87
23_N190_M0.7340.87
56_I113_A0.7310.87
69_L138_I0.7300.87
79_F136_S0.7250.87
44_N165_W0.7250.87
10_V144_Y0.7240.87
120_V181_T0.7240.87
49_T53_S0.7230.86
124_A129_A0.7180.86
156_A160_F0.7170.86
19_F160_F0.7160.86
27_I128_M0.7150.86
99_L104_Q0.7130.86
42_A46_T0.7110.86
61_S138_I0.7080.85
64_L67_T0.7080.85
49_T119_G0.7070.85
28_I167_L0.7040.85
23_N29_P0.7040.85
58_L157_I0.7000.85
100_G103_K0.6990.85
93_S96_S0.6920.84
91_A198_G0.6860.83
24_P160_F0.6850.83
28_I168_F0.6830.83
23_N61_S0.6820.83
78_S82_A0.6800.83
28_I32_I0.6740.82
45_K206_I0.6730.82
24_P131_P0.6710.82
23_N133_A0.6710.82
181_T185_V0.6700.82
97_G188_R0.6660.82
129_A191_G0.6650.82
83_G135_S0.6630.81
97_G191_G0.6620.81
91_A184_N0.6580.81
20_A192_L0.6580.81
132_G188_R0.6570.81
112_T180_Q0.6460.80
18_L58_L0.6450.80
31_F75_S0.6420.79
189_I193_L0.6390.79
133_A157_I0.6350.78
206_I210_F0.6340.78
91_A95_I0.6270.78
15_F19_F0.6250.77
113_A210_F0.6220.77
151_F154_F0.6200.77
35_T38_Q0.6190.77
20_A77_D0.6140.76
72_F139_V0.6120.76
27_I86_L0.6110.76
180_Q184_N0.6110.76
117_S206_I0.6080.75
77_D203_V0.6050.75
86_L137_T0.6040.75
15_F156_A0.6030.75
159_L177_V0.6000.74
20_A195_M0.5990.74
83_G94_M0.5970.74
47_N186_I0.5970.74
93_S102_D0.5950.74
155_V159_L0.5920.74
71_L197_L0.5920.74
145_H152_G0.5900.73
17_G21_L0.5850.73
125_L192_L0.5850.73
25_V186_I0.5820.72
69_L75_S0.5790.72
23_N82_A0.5780.72
79_F192_L0.5750.71
46_T50_A0.5720.71
69_L83_G0.5710.71
62_L189_I0.5700.71
21_L197_L0.5700.71
61_S128_M0.5690.71
17_G192_L0.5650.70
97_G184_N0.5650.70
111_E166_G0.5640.70
132_G194_L0.5630.70
19_F93_S0.5620.70
190_M201_F0.5620.70
121_V194_L0.5610.70
127_L130_G0.5600.69
72_F198_G0.5590.69
41_A44_N0.5570.69
50_A124_A0.5550.69
17_G73_G0.5540.69
87_V197_L0.5530.68
186_I210_F0.5520.68
42_A45_K0.5500.68
29_P128_M0.5500.68
95_I198_G0.5500.68
98_K101_E0.5490.68
148_S177_V0.5450.67
74_I100_G0.5420.67
97_G190_M0.5410.67
32_I186_I0.5400.67
174_L178_L0.5400.67
34_M118_I0.5390.66
12_F64_L0.5390.66
152_G156_A0.5370.66
62_L157_I0.5360.66
57_I170_M0.5360.66
86_L127_L0.5320.65
129_A193_L0.5320.65
67_T189_I0.5310.65
53_S61_S0.5300.65
135_S138_I0.5290.65
65_G130_G0.5280.65
97_G194_L0.5270.65
70_Q176_R0.5260.65
54_V128_M0.5250.64
119_G123_L0.5240.64
140_W153_F0.5230.64
41_A177_V0.5220.64
118_I123_L0.5200.64
99_L103_K0.5200.64
69_L79_F0.5160.63
185_V189_I0.5160.63
27_I123_L0.5160.63
32_I123_L0.5150.63
29_P127_L0.5150.63
21_L57_I0.5120.63
78_S209_I0.5120.63
149_Y152_G0.5110.62
177_V180_Q0.5100.62
79_F210_F0.5080.62
65_G122_P0.5060.62
25_V190_M0.5060.62
18_L178_L0.5030.61
148_S176_R0.5020.61
64_L139_V0.5000.61
45_K166_G0.5000.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2cfqA 1 0.5209 20.6 0.948 Contact Map
4w6vA 1 0.4698 17.6 0.95 Contact Map
4k0jA 3 0.8512 16.2 0.95 Contact Map
3w9iA 3 0.9256 11.7 0.953 Contact Map
4xnjA 1 0.9442 11.1 0.954 Contact Map
3ne5A 3 0.9395 8.9 0.956 Contact Map
4hw9A 3 0.307 7.5 0.957 Contact Map
1pw4A 1 0.5163 7.5 0.957 Contact Map
4kjrA 3 0.3581 6.9 0.958 Contact Map
4wgvA 2 0.3907 6.7 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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