GREMLIN Database
RFAQ - Lipopolysaccharide core heptosyltransferase RfaQ
UniProt: P25742 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11341
Length: 344 (312)
Sequences: 5646 (4531)
Seq/√Len: 256.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
27_D76_Y4.6221.00
175_V251_A4.0841.00
46_A74_N3.3961.00
253_L327_T3.1341.00
18_K45_N2.9501.00
176_I196_I2.9321.00
198_A324_I2.8851.00
191_K320_A2.7981.00
202_R328_E2.6671.00
193_S226_G2.6551.00
262_G274_S2.5511.00
25_K45_N2.5041.00
240_R243_E2.4671.00
25_K46_A2.4601.00
192_F257_V2.4551.00
189_N222_E2.4021.00
126_T134_S2.3981.00
217_L221_D2.3941.00
175_V209_T2.3701.00
175_V248_I2.3211.00
309_D314_Y2.2711.00
304_T314_Y2.2471.00
7_M38_L2.2271.00
159_K243_E2.2031.00
301_K304_T2.1861.00
244_L261_P2.1771.00
188_D191_K2.1591.00
157_W249_D2.1241.00
195_V324_I2.1211.00
256_G262_G2.0961.00
35_I39_S2.0621.00
301_K314_Y2.0501.00
301_K309_D2.0421.00
195_V255_I2.0201.00
304_T309_D2.0191.00
172_H252_V2.0141.00
27_D45_N1.9951.00
161_R250_H1.9871.00
173_Y250_H1.9741.00
220_V236_A1.9491.00
174_V199_L1.9321.00
187_W191_K1.9271.00
171_D205_Q1.9071.00
208_L220_V1.8771.00
156_C242_P1.8681.00
197_D227_C1.8351.00
13_V82_L1.8291.00
187_W323_V1.8181.00
210_C237_G1.7841.00
10_T82_L1.7811.00
200_Q231_P1.7691.00
255_I327_T1.7681.00
27_D46_A1.7581.00
32_Q51_S1.7101.00
27_D48_Y1.7011.00
321_E325_A1.6931.00
198_A202_R1.6671.00
198_A321_E1.6651.00
134_S137_E1.6541.00
313_K317_V1.6501.00
197_D228_E1.6471.00
187_W192_F1.6371.00
173_Y252_V1.6321.00
173_Y251_A1.6231.00
174_V204_Y1.6081.00
245_G264_I1.5991.00
319_P322_D1.5931.00
191_K194_K1.5751.00
99_M119_H1.5671.00
254_F270_T1.5661.00
174_V253_L1.5621.00
27_D74_N1.5611.00
221_D225_R1.5381.00
36_P39_S1.5101.00
136_L141_I1.4991.00
65_L69_K1.4811.00
194_K197_D1.4611.00
173_Y207_V1.4101.00
113_W116_S1.3931.00
248_I268_V1.3891.00
15_S149_T1.3671.00
177_Q256_G1.3551.00
177_Q259_S1.3491.00
178_P208_L1.3491.00
220_V234_G1.3461.00
180_A186_C1.3411.00
296_A322_D1.3361.00
15_S19_Q1.3321.00
312_K315_L1.3291.00
93_R100_K1.3281.00
172_H204_Y1.3271.00
97_A100_K1.3231.00
79_V92_V1.3161.00
163_E243_E1.3061.00
21_Y24_A1.3041.00
78_L101_I1.2961.00
9_L284_W1.2911.00
173_Y205_Q1.2821.00
221_D234_G1.2751.00
153_A156_C1.2711.00
18_K26_I1.2671.00
60_K63_N1.2651.00
209_T244_L1.2601.00
198_A320_A1.2381.00
234_G237_G1.2321.00
199_L327_T1.2311.00
28_M38_L1.2261.00
186_C219_C1.2121.00
130_E287_W1.2081.00
15_S43_E1.2051.00
187_W195_V1.1971.00
205_Q233_T1.1951.00
222_E226_G1.1921.00
179_T216_D1.1881.00
154_E158_K1.1851.00
185_K258_D1.1851.00
199_L324_I1.1801.00
254_F265_A1.1761.00
210_C234_G1.1731.00
288_T291_I1.1691.00
253_L273_I1.1661.00
193_S197_D1.1601.00
198_A201_Q1.1591.00
14_I28_M1.1381.00
188_D316_S1.1281.00
175_V247_L1.1221.00
159_K163_E1.1221.00
11_T41_N1.1201.00
292_I326_A1.1151.00
156_C243_E1.1141.00
81_N88_V1.1131.00
35_I49_G1.1101.00
18_K24_A1.1081.00
193_S223_I1.1061.00
79_V97_A1.1041.00
256_G274_S1.0961.00
13_V136_L1.0871.00
40_E242_P1.0821.00
324_I328_E1.0681.00
7_M34_T1.0641.00
194_K198_A1.0601.00
30_L47_L1.0591.00
224_A234_G1.0581.00
190_D316_S1.0551.00
189_N223_I1.0541.00
35_I47_L1.0521.00
42_P151_S1.0491.00
119_H122_P1.0461.00
20_N141_I1.0451.00
196_I208_L1.0351.00
196_I227_C1.0261.00
318_I322_D1.0231.00
275_L318_I1.0201.00
195_V198_A1.0201.00
248_I270_T1.0201.00
193_S227_C1.0191.00
62_K66_S1.0101.00
176_I255_I1.0071.00
147_D269_K1.0061.00
7_M28_M0.9981.00
179_T186_C0.9931.00
179_T219_C0.9921.00
163_E167_L0.9911.00
273_I327_T0.9901.00
322_D326_A0.9821.00
296_A299_Y0.9801.00
217_L238_K0.9761.00
209_T251_A0.9761.00
68_I72_R0.9761.00
185_K279_T0.9751.00
113_W117_F0.9691.00
216_D219_C0.9681.00
195_V320_A0.9591.00
197_D201_Q0.9581.00
160_M246_A0.9571.00
158_K162_R0.9521.00
4_H34_T0.9491.00
16_T19_Q0.9411.00
222_E225_R0.9401.00
177_Q209_T0.9401.00
295_W302_M0.9351.00
218_A221_D0.9281.00
159_K162_R0.9281.00
3_Y181_R0.9271.00
187_W320_A0.9221.00
180_A257_V0.9211.00
190_D222_E0.9181.00
78_L99_M0.9141.00
239_T247_L0.9131.00
39_S242_P0.9111.00
194_K321_E0.9071.00
221_D224_A0.9071.00
36_P242_P0.9001.00
194_K320_A0.8971.00
186_C257_V0.8941.00
173_Y204_Y0.8901.00
127_H285_R0.8891.00
322_D325_A0.8881.00
207_V247_L0.8881.00
28_M44_I0.8861.00
8_L264_I0.8831.00
16_T20_N0.8831.00
281_H295_W0.8811.00
126_T130_E0.8721.00
273_I326_A0.8711.00
182_Q185_K0.8701.00
248_I254_F0.8691.00
63_N66_S0.8681.00
211_G216_D0.8671.00
179_T257_V0.8661.00
218_A222_E0.8631.00
24_A77_D0.8621.00
177_Q254_F0.8621.00
321_E324_I0.8591.00
202_R324_I0.8550.99
118_T121_A0.8520.99
220_V224_A0.8480.99
129_V287_W0.8450.99
200_Q206_V0.8450.99
262_G276_F0.8310.99
191_K319_P0.8300.99
96_P100_K0.8250.99
245_G268_V0.8220.99
175_V254_F0.8170.99
258_D276_F0.8170.99
3_Y7_M0.8060.99
246_A249_D0.8020.99
3_Y83_T0.7990.99
227_C232_I0.7990.99
249_D270_T0.7970.99
213_S217_L0.7960.99
234_G238_K0.7890.99
255_I273_I0.7870.99
12_P133_L0.7820.99
204_Y252_V0.7810.99
18_K43_E0.7780.99
32_Q35_I0.7770.99
40_E246_A0.7720.99
275_L323_V0.7710.99
79_V95_L0.7690.99
174_V255_I0.7670.99
299_Y302_M0.7650.99
208_L232_I0.7640.99
165_D168_G0.7630.99
296_A302_M0.7580.99
16_T133_L0.7570.99
296_A317_V0.7560.99
196_I223_I0.7560.99
100_K118_T0.7470.99
25_K76_Y0.7460.99
203_G206_V0.7460.99
71_L95_L0.7460.99
137_E142_T0.7460.99
303_P309_D0.7450.99
170_K205_Q0.7410.99
4_H241_F0.7410.99
294_F297_G0.7370.98
212_P217_L0.7370.98
192_F196_I0.7360.98
128_I131_R0.7340.98
217_L234_G0.7330.98
160_M247_L0.7320.98
299_Y304_T0.7260.98
239_T243_E0.7250.98
235_L239_T0.7230.98
320_A324_I0.7210.98
158_K161_R0.7200.98
114_K118_T0.7190.98
41_N44_I0.7170.98
69_K73_A0.7160.98
7_M30_L0.7140.98
90_L94_C0.7130.98
31_Y34_T0.7100.98
171_D203_G0.7070.98
66_S69_K0.7070.98
187_W275_L0.7050.98
325_A328_E0.7050.98
189_N193_S0.7010.98
302_M305_R0.7000.98
198_A328_E0.6960.98
32_Q49_G0.6960.98
83_T284_W0.6930.98
118_T122_P0.6930.98
169_V205_Q0.6900.98
41_N151_S0.6890.98
46_A70_T0.6890.98
187_W257_V0.6870.98
17_L24_A0.6870.98
17_L26_I0.6850.98
3_Y9_L0.6850.98
11_T148_T0.6830.97
68_I94_C0.6810.97
199_L204_Y0.6800.97
193_S196_I0.6790.97
14_I43_E0.6730.97
127_H287_W0.6700.97
152_Y160_M0.6700.97
29_L67_L0.6690.97
315_L318_I0.6680.97
130_E134_S0.6680.97
262_G272_V0.6670.97
178_P223_I0.6660.97
177_Q284_W0.6660.97
80_I139_L0.6660.97
11_T267_A0.6640.97
277_G315_L0.6640.97
252_V271_P0.6620.97
324_I327_T0.6620.97
235_L238_K0.6610.97
114_K120_L0.6610.97
191_K195_V0.6610.97
92_V100_K0.6550.97
153_A242_P0.6540.97
278_A312_K0.6540.97
157_W161_R0.6520.97
128_I283_F0.6490.97
117_F120_L0.6490.97
130_E146_T0.6460.97
62_K65_L0.6440.96
51_S54_G0.6430.96
273_I292_I0.6430.96
8_L267_A0.6430.96
210_C238_K0.6430.96
89_A102_S0.6380.96
234_G239_T0.6380.96
174_V206_V0.6320.96
179_T211_G0.6300.96
210_C235_L0.6300.96
3_Y259_S0.6290.96
266_A287_W0.6240.96
83_T88_V0.6190.96
197_D200_Q0.6180.96
164_L173_Y0.6170.95
103_Q135_V0.6160.95
251_A270_T0.6160.95
24_A78_L0.6140.95
223_I227_C0.6130.95
186_C192_F0.6110.95
275_L294_F0.6100.95
48_Y74_N0.6080.95
45_N76_Y0.6080.95
45_N74_N0.6070.95
177_Q261_P0.6060.95
228_E231_P0.6060.95
197_D230_K0.6050.95
152_Y157_W0.6040.95
8_L245_G0.6040.95
9_L129_V0.6020.95
65_L94_C0.6000.95
180_A259_S0.6000.95
77_D98_R0.5950.95
115_K118_T0.5940.94
209_T261_P0.5940.94
103_Q107_H0.5930.94
83_T131_R0.5930.94
103_Q106_G0.5920.94
176_I195_V0.5910.94
179_T210_C0.5890.94
210_C239_T0.5890.94
313_K316_S0.5880.94
159_K240_R0.5870.94
208_L223_I0.5850.94
195_V327_T0.5840.94
165_D169_V0.5830.94
95_L100_K0.5810.94
135_V241_F0.5780.94
225_R228_E0.5760.94
178_P259_S0.5740.93
66_S70_T0.5730.93
89_A117_F0.5730.93
11_T40_E0.5730.93
31_Y87_M0.5720.93
82_L136_L0.5710.93
21_Y78_L0.5710.93
265_A272_V0.5700.93
28_M83_T0.5700.93
113_W118_T0.5680.93
239_T244_L0.5670.93
160_M163_E0.5670.93
251_A254_F0.5660.93
248_I264_I0.5650.93
301_K305_R0.5650.93
28_M85_Q0.5650.93
249_D268_V0.5650.93
128_I284_W0.5640.93
104_L122_P0.5640.93
178_P220_V0.5620.93
163_E238_K0.5620.93
70_T73_A0.5620.93
125_G131_R0.5610.93
187_W319_P0.5590.92
286_P293_Q0.5590.92
37_I264_I0.5580.92
64_V68_I0.5580.92
72_R96_P0.5570.92
18_K23_D0.5550.92
51_S63_N0.5540.92
4_H37_I0.5530.92
81_N92_V0.5530.92
272_V286_P0.5520.92
95_L98_R0.5520.92
176_I206_V0.5520.92
210_C236_A0.5510.92
157_W250_H0.5510.92
304_T312_K0.5500.92
200_Q232_I0.5500.92
297_G302_M0.5480.92
40_E153_A0.5480.92
18_K22_P0.5460.92
244_L264_I0.5450.92
79_V100_K0.5450.92
175_V207_V0.5440.91
38_L41_N0.5420.91
272_V276_F0.5410.91
280_D284_W0.5410.91
208_L224_A0.5400.91
114_K117_F0.5370.91
81_N85_Q0.5370.91
236_A239_T0.5360.91
181_R284_W0.5360.91
139_L142_T0.5350.91
172_H203_G0.5340.91
69_K72_R0.5330.91
117_F121_A0.5330.91
154_E157_W0.5320.91
101_I138_P0.5310.90
262_G266_A0.5310.90
182_Q278_A0.5300.90
248_I261_P0.5290.90
269_K290_N0.5280.90
14_I44_I0.5280.90
4_H8_L0.5280.90
273_I323_V0.5270.90
9_L127_H0.5270.90
300_Q304_T0.5270.90
128_I132_N0.5250.90
85_Q88_V0.5220.90
306_H309_D0.5220.90
176_I192_F0.5220.90
89_A92_V0.5220.90
17_L80_I0.5200.90
197_D226_G0.5190.89
254_F272_V0.5190.89
170_K252_V0.5190.89
190_D194_K0.5180.89
246_A250_H0.5180.89
12_P15_S0.5180.89
3_Y28_M0.5180.89
302_M309_D0.5170.89
102_S117_F0.5150.89
16_T136_L0.5140.89
191_K316_S0.5120.89
3_Y34_T0.5090.89
273_I294_F0.5090.89
7_M83_T0.5090.89
19_Q147_D0.5080.88
83_T283_F0.5080.88
196_I206_V0.5080.88
8_L41_N0.5070.88
307_E310_R0.5060.88
92_V102_S0.5060.88
46_A76_Y0.5050.88
210_C216_D0.5040.88
188_D315_L0.5040.88
172_H205_Q0.5040.88
301_K312_K0.5030.88
177_Q257_V0.5020.88
92_V97_A0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tovA 1 0.936 100 0.307 Contact Map
1pswA 1 0.9041 100 0.311 Contact Map
2gt1A 1 0.9041 100 0.351 Contact Map
4rapA 3 0.7849 100 0.482 Contact Map
3ot5A 2 0.9012 99 0.835 Contact Map
4rifA 2 0.8895 98.6 0.857 Contact Map
4hwgA 5 0.8953 98.6 0.858 Contact Map
4nesA 2 0.8983 98.5 0.861 Contact Map
1v4vA 2 0.9012 98.4 0.866 Contact Map
4fkzA 2 0.907 98.3 0.869 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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