GREMLIN Database
LYSP - Lysine-specific permease
UniProt: P25737 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11337
Length: 489 (425)
Sequences: 24749 (15964)
Seq/√Len: 774.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
142_F353_T4.3521.00
335_I347_N4.1491.00
395_R399_G3.3941.00
387_L425_F3.2101.00
59_G250_L3.1461.00
338_K347_N3.0731.00
236_K240_R3.0621.00
18_K232_E2.8621.00
83_A329_D2.7501.00
456_G460_F2.6571.00
233_D236_K2.6471.00
231_S237_N2.6041.00
174_G259_I2.5991.00
99_G326_L2.5761.00
23_T244_Q2.5741.00
460_F464_W2.5361.00
327_A337_A2.5331.00
135_A357_G2.4941.00
340_S346_R2.4761.00
295_S299_V2.4751.00
229_G328_C2.4631.00
19_A244_Q2.3901.00
335_I338_K2.3871.00
172_I176_L2.3781.00
390_A424_A2.2781.00
71_E397_R2.2641.00
87_Q95_G2.1871.00
350_Y354_V2.1441.00
143_L147_I2.1421.00
422_I426_I2.1241.00
230_E321_R2.1081.00
19_A23_T2.1041.00
324_Y328_C2.0981.00
19_A237_N2.0971.00
142_F349_L2.0941.00
189_G192_N2.0821.00
453_T456_G2.0811.00
22_L231_S2.0391.00
150_R154_E2.0131.00
139_G357_G1.9971.00
240_R244_Q1.9781.00
134_S360_F1.9621.00
146_Y346_R1.9561.00
23_T248_R1.9551.00
18_K21_H1.9311.00
161_L165_T1.9311.00
419_L423_F1.9301.00
330_G334_R1.9171.00
90_V395_R1.9061.00
87_Q92_E1.9061.00
286_L289_Q1.9001.00
13_L339_L1.8951.00
68_S390_A1.8931.00
135_A360_F1.8931.00
268_D290_H1.8741.00
60_L64_F1.8631.00
265_P268_D1.8561.00
103_W352_T1.8401.00
336_F351_A1.8401.00
243_R247_W1.8241.00
42_T51_A1.8171.00
391_I425_F1.7861.00
90_V391_I1.7801.00
426_I430_I1.7721.00
464_W468_K1.7421.00
340_S344_V1.7351.00
139_G353_T1.7351.00
233_D237_N1.7341.00
280_S286_L1.7061.00
145_N313_N1.6981.00
21_H157_Y1.6581.00
98_L388_G1.6551.00
86_G98_L1.6461.00
165_T169_V1.6401.00
26_A245_V1.6191.00
91_E94_F1.6181.00
460_F463_I1.6181.00
54_S210_V1.6151.00
247_W251_L1.6141.00
146_Y350_Y1.6011.00
17_L21_H1.5891.00
342_G346_R1.5871.00
61_M427_L1.5681.00
395_R398_R1.5621.00
114_L312_G1.5611.00
138_L356_A1.5491.00
64_F423_F1.5421.00
233_D240_R1.5411.00
286_L290_H1.5321.00
190_W193_W1.5191.00
110_I356_A1.5121.00
454_Y458_P1.4931.00
463_I467_Y1.4891.00
121_M133_W1.4801.00
166_T303_V1.4731.00
347_N351_A1.4681.00
49_G200_F1.4671.00
147_I342_G1.4651.00
114_L138_L1.4611.00
459_L463_I1.4601.00
227_A317_Y1.4531.00
456_G459_L1.4511.00
79_S229_G1.4511.00
164_V168_I1.4471.00
175_V259_I1.4411.00
14_R343_G1.4391.00
334_R338_K1.4291.00
462_I466_G1.4161.00
58_I214_V1.4101.00
319_S352_T1.4101.00
391_I395_R1.3981.00
117_A305_L1.3971.00
324_Y339_L1.3951.00
323_L348_A1.3951.00
135_A139_G1.3941.00
86_G388_G1.3771.00
138_L353_T1.3711.00
289_Q297_A1.3671.00
406_D410_L1.3581.00
90_V94_F1.3541.00
66_M246_F1.3501.00
128_T131_W1.3491.00
458_P462_I1.3391.00
60_L423_F1.3361.00
338_K346_R1.3291.00
334_R337_A1.3271.00
465_F469_L1.3241.00
142_F350_Y1.3201.00
298_A302_A1.3121.00
17_L22_L1.3101.00
13_L324_Y1.3081.00
456_G463_I1.3051.00
320_T349_L1.2981.00
117_A137_F1.2961.00
455_I459_L1.2801.00
21_H153_G1.2681.00
282_S286_L1.2671.00
251_L255_F1.2671.00
407_I410_L1.2661.00
76_M88_N1.2641.00
234_P239_P1.2481.00
461_L465_F1.2481.00
66_M242_V1.2481.00
19_A240_R1.2481.00
20_R24_M1.2461.00
68_S421_P1.2451.00
30_S249_I1.2331.00
89_Y392_S1.2331.00
323_L332_A1.2291.00
65_L390_A1.2271.00
67_T243_R1.2161.00
17_L153_G1.2151.00
416_F420_G1.2141.00
113_D311_A1.2131.00
178_I262_L1.2091.00
141_I312_G1.2071.00
237_N240_R1.2061.00
22_L241_A1.2061.00
37_V116_A1.2031.00
171_I255_F1.1961.00
144_L155_A1.1951.00
52_L258_L1.1931.00
75_Y410_L1.1871.00
456_G464_W1.1861.00
84_T88_N1.1811.00
463_I466_G1.1611.00
387_L429_L1.1591.00
453_T460_F1.1581.00
155_A159_F1.1471.00
418_P422_I1.1451.00
132_I136_L1.1431.00
174_G263_I1.1391.00
26_A224_I1.1381.00
430_I434_G1.1331.00
93_G467_Y1.1331.00
175_V179_I1.1331.00
394_Y422_I1.1291.00
103_W323_L1.1251.00
419_L422_I1.1231.00
189_G193_W1.1171.00
25_I227_A1.1101.00
408_N411_P1.1101.00
49_G207_M1.1101.00
289_Q294_L1.1081.00
69_L82_F1.1041.00
27_I248_R1.1011.00
78_V84_T1.1001.00
466_G469_L1.1001.00
168_I172_I1.1001.00
266_Y269_P1.0991.00
88_N400_Y1.0961.00
280_S283_P1.0941.00
136_L140_V1.0911.00
169_V173_V1.0871.00
170_F174_G1.0851.00
96_F100_W1.0841.00
43_I51_A1.0841.00
83_A325_T1.0801.00
464_W467_Y1.0801.00
100_W460_F1.0731.00
439_A442_K1.0661.00
339_L343_G1.0631.00
347_N350_Y1.0631.00
425_F429_L1.0581.00
73_A85_Y1.0561.00
16_E232_E1.0521.00
156_E313_N1.0481.00
410_L413_R1.0481.00
232_E237_N1.0401.00
56_M254_V1.0381.00
203_G206_A1.0381.00
139_G143_L1.0361.00
64_F420_G1.0331.00
354_V358_L1.0331.00
154_E158_W1.0321.00
436_N439_A1.0301.00
176_L181_I1.0281.00
429_L433_L1.0281.00
457_I460_F1.0271.00
208_I430_I1.0231.00
328_C337_A1.0151.00
187_P190_W1.0111.00
265_P290_H1.0101.00
393_H421_P1.0071.00
387_L428_C1.0021.00
142_F146_Y0.9991.00
452_A456_G0.9941.00
71_E74_A0.9851.00
27_I249_I0.9831.00
149_V317_Y0.9821.00
398_R418_P0.9801.00
146_Y344_V0.9801.00
228_A238_I0.9791.00
78_V88_N0.9781.00
46_A49_G0.9771.00
200_F207_M0.9741.00
146_Y340_S0.9631.00
458_P461_L0.9631.00
191_S194_T0.9591.00
195_I198_A0.9591.00
416_F419_L0.9571.00
417_F421_P0.9561.00
121_M305_L0.9561.00
164_V252_F0.9551.00
86_G94_F0.9541.00
176_L180_G0.9511.00
121_M125_F0.9491.00
56_M60_L0.9481.00
219_Q382_G0.9481.00
456_G461_L0.9481.00
457_I461_L0.9371.00
222_E226_I0.9371.00
436_N440_F0.9351.00
118_Q133_W0.9291.00
80_G84_T0.9281.00
316_M353_T0.9251.00
159_F310_S0.9241.00
244_Q248_R0.9241.00
452_A459_L0.9231.00
263_I287_V0.9191.00
171_I259_I0.9191.00
459_L462_I0.9181.00
163_K307_A0.9161.00
294_L298_A0.9161.00
75_Y408_N0.9161.00
118_Q134_S0.9141.00
453_T457_I0.9131.00
424_A428_C0.9071.00
59_G218_F0.9011.00
87_Q329_D0.9011.00
16_E150_R0.9001.00
387_L391_I0.8991.00
464_W469_L0.8951.00
52_L261_S0.8941.00
24_M157_Y0.8921.00
346_R350_Y0.8901.00
400_Y407_I0.8891.00
74_A411_P0.8861.00
141_I313_N0.8841.00
293_L296_A0.8831.00
91_E468_K0.8811.00
336_F347_N0.8801.00
250_L254_V0.8771.00
170_F288_F0.8771.00
31_I34_G0.8741.00
112_V375_L0.8721.00
140_V309_L0.8711.00
340_S343_G0.8701.00
461_L464_W0.8701.00
292_G296_A0.8671.00
390_A425_F0.8661.00
332_A336_F0.8651.00
432_T440_F0.8641.00
200_F203_G0.8621.00
459_L467_Y0.8621.00
454_Y459_L0.8601.00
129_P132_I0.8581.00
409_D412_Y0.8571.00
65_L428_C0.8511.00
112_V216_F0.8491.00
117_A308_V0.8451.00
86_G392_S0.8431.00
100_W332_A0.8421.00
19_A241_A0.8371.00
49_G199_P0.8361.00
458_P463_I0.8351.00
175_V255_F0.8341.00
192_N195_I0.8301.00
179_I187_P0.8301.00
408_N413_R0.8291.00
21_H154_E0.8281.00
433_L437_Y0.8281.00
63_Y67_T0.8271.00
353_T357_G0.8271.00
190_W262_L0.8201.00
117_A309_L0.8191.00
288_F293_L0.8181.00
20_R157_Y0.8181.00
171_I175_V0.8151.00
133_W136_L0.8151.00
13_L321_R0.8141.00
209_G213_I0.8071.00
460_F468_K0.8061.00
412_Y415_G0.8041.00
394_Y421_P0.8041.00
197_E200_F0.8041.00
454_Y457_I0.8031.00
400_Y406_D0.8031.00
453_T458_P0.8021.00
190_W194_T0.8001.00
138_L360_F0.8001.00
409_D413_R0.7951.00
53_L207_M0.7951.00
80_G83_A0.7931.00
455_I460_F0.7931.00
154_E157_Y0.7921.00
453_T459_L0.7921.00
115_V374_L0.7911.00
438_E442_K0.7911.00
141_I316_M0.7901.00
75_Y406_D0.7901.00
223_L318_A0.7901.00
63_Y243_R0.7861.00
118_Q121_M0.7851.00
189_G194_T0.7831.00
128_T132_I0.7821.00
258_L262_L0.7801.00
143_L146_Y0.7801.00
453_T464_W0.7751.00
455_I458_P0.7731.00
31_I163_K0.7731.00
13_L230_E0.7721.00
178_I259_I0.7701.00
451_A454_Y0.7671.00
431_I435_Q0.7661.00
394_Y418_P0.7661.00
219_Q386_W0.7591.00
400_Y410_L0.7561.00
282_S285_T0.7551.00
406_D409_D0.7541.00
432_T435_Q0.7531.00
204_F207_M0.7511.00
72_L85_Y0.7501.00
72_L393_H0.7461.00
64_F68_S0.7451.00
393_H397_R0.7411.00
463_I469_L0.7411.00
283_P287_V0.7401.00
354_V357_G0.7381.00
93_G97_A0.7381.00
233_D239_P0.7341.00
53_L57_L0.7321.00
23_T241_A0.7301.00
109_T378_S0.7301.00
239_P242_V0.7291.00
102_Y106_W0.7281.00
377_T381_T0.7231.00
94_F388_G0.7231.00
48_P261_S0.7201.00
20_R23_T0.7201.00
107_A355_I0.7191.00
171_I256_A0.7161.00
147_I151_G0.7151.00
35_L256_A0.7141.00
415_G419_L0.7141.00
460_F467_Y0.7121.00
188_A191_S0.7111.00
90_V392_S0.7091.00
101_N385_A0.7071.00
145_N349_L0.7071.00
394_Y398_R0.7051.00
418_P421_P0.7041.00
89_Y395_R0.7031.00
198_A201_A0.7001.00
16_E149_V0.6991.00
283_P288_F0.6981.00
284_F288_F0.6961.00
407_I411_P0.6961.00
430_I433_L0.6901.00
30_S245_V0.6881.00
457_I464_W0.6871.00
279_I283_P0.6871.00
452_A455_I0.6861.00
244_Q247_W0.6851.00
288_F291_A0.6801.00
321_R324_Y0.6801.00
83_A87_Q0.6781.00
392_S396_F0.6771.00
335_I351_A0.6771.00
295_S298_A0.6761.00
255_F259_I0.6761.00
153_G157_Y0.6761.00
400_Y408_N0.6761.00
452_A460_F0.6751.00
187_P191_S0.6741.00
20_R154_E0.6731.00
31_I252_F0.6721.00
146_Y342_G0.6711.00
105_N382_G0.6701.00
406_D411_P0.6681.00
414_S417_F0.6681.00
53_L56_M0.6681.00
229_G324_Y0.6671.00
89_Y396_F0.6661.00
162_I303_V0.6641.00
64_F424_A0.6641.00
135_A361_L0.6641.00
323_L351_A0.6631.00
452_A461_L0.6601.00
109_T112_V0.6571.00
208_I434_G0.6541.00
316_M320_T0.6541.00
62_V221_T0.6541.00
341_R346_R0.6531.00
131_W135_A0.6521.00
162_I166_T0.6501.00
428_C431_I0.6481.00
82_F222_E0.6471.00
108_V377_T0.6461.00
66_M221_T0.6461.00
283_P286_L0.6451.00
151_G154_E0.6441.00
109_T113_D0.6441.00
435_Q439_A0.6441.00
72_L89_Y0.6431.00
320_T348_A0.6411.00
32_G36_F0.6411.00
336_F348_A0.6401.00
235_A409_D0.6391.00
83_A99_G0.6391.00
146_Y349_L0.6391.00
69_L389_I0.6381.00
124_W302_A0.6371.00
394_Y425_F0.6351.00
79_S324_Y0.6351.00
381_T385_A0.6341.00
111_A359_C0.6341.00
145_N317_Y0.6331.00
319_S323_L0.6331.00
137_F312_G0.6281.00
248_R252_F0.6281.00
279_I282_S0.6271.00
28_G160_S0.6271.00
38_A375_L0.6271.00
141_I309_L0.6251.00
16_E20_R0.6251.00
111_A374_L0.6251.00
81_S225_G0.6241.00
153_G313_N0.6231.00
248_R251_L0.6231.00
433_L436_N0.6231.00
193_W261_S0.6221.00
307_A310_S0.6221.00
436_N441_L0.6191.00
68_S424_A0.6181.00
52_L254_V0.6171.00
417_F420_G0.6161.00
140_V144_L0.6161.00
452_A463_I0.6151.00
52_L56_M0.6151.00
176_L179_I0.6141.00
188_A192_N0.6121.00
117_A121_M0.6121.00
138_L357_G0.6121.00
57_L211_A0.6111.00
200_F204_F0.6091.00
31_I36_F0.6091.00
51_A257_I0.6081.00
421_P425_F0.6071.00
73_A225_G0.6061.00
238_I242_V0.6051.00
219_Q222_E0.6051.00
120_V304_I0.6021.00
339_L342_G0.6021.00
113_D116_A0.5991.00
302_A306_T0.5971.00
256_A260_I0.5971.00
149_V227_A0.5961.00
345_P348_A0.5951.00
29_G315_G0.5951.00
91_E95_G0.5931.00
29_G314_S0.5911.00
136_L139_G0.5911.00
231_S238_I0.5901.00
151_G155_A0.5891.00
83_A95_G0.5881.00
206_A209_G0.5871.00
39_S257_I0.5851.00
58_I218_F0.5841.00
70_G74_A0.5841.00
458_P464_W0.5841.00
23_T26_A0.5831.00
225_G242_V0.5811.00
453_T461_L0.5811.00
459_L464_W0.5801.00
142_F316_M0.5801.00
121_M137_F0.5791.00
157_Y161_L0.5781.00
73_A238_I0.5781.00
380_M432_T0.5781.00
226_I318_A0.5771.00
284_F287_V0.5771.00
82_F226_I0.5771.00
139_G142_F0.5761.00
453_T467_Y0.5751.00
316_M349_L0.5741.00
387_L432_T0.5741.00
111_A356_A0.5741.00
173_V177_M0.5711.00
55_Y217_S0.5701.00
426_I429_L0.5691.00
106_W315_G0.5691.00
323_L327_A0.5671.00
71_E415_G0.5661.00
460_F465_F0.5661.00
114_L118_Q0.5651.00
451_A464_W0.5651.00
327_A336_F0.5641.00
287_V291_A0.5641.00
461_L467_Y0.5631.00
396_F400_Y0.5631.00
189_G262_L0.5621.00
139_G350_Y0.5621.00
465_F468_K0.5621.00
86_G95_G0.5611.00
372_L375_L0.5611.00
123_W301_N0.5601.00
29_G223_L0.5591.00
27_I160_S0.5581.00
410_L414_S0.5571.00
424_A427_L0.5561.00
423_F426_I0.5551.00
113_D308_V0.5551.00
283_P291_A0.5551.00
197_E201_A0.5551.00
124_W301_N0.5531.00
160_S163_K0.5531.00
157_Y160_S0.5521.00
158_W161_L0.5511.00
397_R417_F0.5501.00
58_I215_G0.5501.00
235_A240_R0.5501.00
13_L16_E0.5491.00
67_T420_G0.5491.00
187_P193_W0.5471.00
98_L385_A0.5461.00
421_P435_Q0.5461.00
63_Y247_W0.5461.00
299_V303_V0.5451.00
41_A44_S0.5441.00
26_A30_S0.5431.00
90_V93_G0.5431.00
259_I262_L0.5431.00
42_T46_A0.5421.00
222_E386_W0.5421.00
137_F309_L0.5411.00
406_D413_R0.5411.00
25_I28_G0.5401.00
113_D312_G0.5401.00
188_A194_T0.5401.00
361_L364_M0.5381.00
351_A355_I0.5361.00
122_S130_G0.5351.00
148_S151_G0.5331.00
456_G468_K0.5331.00
93_G461_L0.5321.00
248_R255_F0.5321.00
234_P237_N0.5321.00
66_M70_G0.5321.00
438_E441_L0.5301.00
187_P192_N0.5291.00
219_Q378_S0.5251.00
195_I201_A0.5241.00
75_Y411_P0.5241.00
42_T214_V0.5231.00
52_L55_Y0.5231.00
166_T299_V0.5221.00
460_F469_L0.5221.00
358_L361_L0.5211.00
22_L237_N0.5201.00
107_A352_T0.5191.00
162_I306_T0.5181.00
231_S241_A0.5171.00
41_A372_L0.5171.00
270_S280_S0.5151.00
428_C432_T0.5141.00
195_I199_P0.5141.00
383_F428_C0.5131.00
152_F317_Y0.5131.00
288_F296_A0.5121.00
415_G420_G0.5121.00
24_M160_S0.5111.00
125_F133_W0.5111.00
421_P424_A0.5111.00
407_I413_R0.5101.00
137_F141_I0.5091.00
452_A458_P0.5091.00
75_Y396_F0.5081.00
459_L466_G0.5081.00
18_K150_R0.5081.00
457_I463_I0.5081.00
224_I242_V0.5071.00
235_A411_P0.5071.00
140_V143_L0.5061.00
452_A457_I0.5061.00
39_S42_T0.5061.00
456_G467_Y0.5051.00
40_G43_I0.5051.00
226_I322_M0.5041.00
54_S57_L0.5041.00
48_P52_L0.5041.00
230_E345_P0.5031.00
55_Y253_Y0.5031.00
451_A456_G0.5021.00
224_I238_I0.5021.00
65_L222_E0.5011.00
264_I268_D0.5001.00
70_G242_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.8528 100 0.342 Contact Map
3giaA 1 0.8753 100 0.382 Contact Map
4djkA 2 0.8609 100 0.385 Contact Map
3dh4A 3 0.8978 99.1 0.852 Contact Map
2xq2A 2 0.8998 99.1 0.858 Contact Map
2jlnA 1 0.8589 99 0.863 Contact Map
4wgvA 2 0.7607 97.4 0.909 Contact Map
4xp4A 1 0.91 96.8 0.918 Contact Map
2a65A 2 0.8998 95.8 0.925 Contact Map
4us3A 1 0.8078 94.2 0.932 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0146 seconds.