LYSP - ECOLI - GREMLIN Contacts

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LYSP - Lysine-specific permease

UniProt:	P25737	Sequences: MVSETKTTEAPGLRRELKARHLTMIAIGGSIGTGLFVASGATISQAGPGGALLSYMLIGLMVYFLMTSLGELAAYMPVSGSFATYGQNYVEEGFGFALGWNYWYNWAVTIAVDLVAAQLVMSWWFPDTPGWIWSALFLGVIFLLNYISVRGFGEAEYWFSLIKVTTVIVFIIVGVLMIIGIFKGAQPAGWSNWTIGEAPFAGGFAAMIGVAMIVGFSFQGTELIGIAAGESEDPAKNIPRAVRQVFWRILLFYVFAILIISLIIPYTDPSLLRNDVKDISVSPFTLVFQHAGLLSAAAVMNAVILTAVLSAGNSGMYASTRMLYTLACDGKAPRIFAKLSRGGVPRNALYATTVIAGLCFLTSMFGNQTVYLWLLNTSGMTGFIAWLGIAISHYRFRRGYVLQGHDINDLPYRSGFFPLGPIFAFILCLIITLGQNYEAFLKDTIDWGGVAATYIGIPLFLIIWFGYKLIKGTHFVRYSEMKFPQNDKK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11337
Length:	489 (425)
Sequences:	24749 (15964)
Seq/√Len:	774.4

ECOLI - LYSP GABP MMUP ANSP PROY YIFK AROP PHEP CYCA PUUP PLAP FRLA GADC POTE ADIC YGJI YJEM YCAM YBAT CADB ARCD YJEH
BACSU - YBGF ROCC GABP HUTM YBXG YTNA ROCE YVBW YDGF AAPA ASPP YBEC YHDG STET YFNA YCGH ARCD YECA YDAO GERBB GERAB YNDE GERKB
HALSA - Q9HHU7 Q9HQB3 Q9HSL5
SULSO - Q97ZB5 Q97WS3 Q97X49 Q97Z63 Q7LXI7 Q97U05 Q97XM0 Q97VA6 Q97WD4 Q97U33 Q97VA8 Q97VR4 Q97Y76 Q97YN3 Q97YX9 Q97U39

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
142_F	353_T	4.352	1.00
335_I	347_N	4.149	1.00
395_R	399_G	3.394	1.00
387_L	425_F	3.210	1.00
59_G	250_L	3.146	1.00
338_K	347_N	3.073	1.00
236_K	240_R	3.062	1.00
18_K	232_E	2.862	1.00
83_A	329_D	2.750	1.00
456_G	460_F	2.657	1.00
233_D	236_K	2.647	1.00
231_S	237_N	2.604	1.00
174_G	259_I	2.599	1.00
99_G	326_L	2.576	1.00
23_T	244_Q	2.574	1.00
460_F	464_W	2.536	1.00
327_A	337_A	2.533	1.00
135_A	357_G	2.494	1.00
340_S	346_R	2.476	1.00
295_S	299_V	2.475	1.00
229_G	328_C	2.463	1.00
19_A	244_Q	2.390	1.00
335_I	338_K	2.387	1.00
172_I	176_L	2.378	1.00
390_A	424_A	2.278	1.00
71_E	397_R	2.264	1.00
87_Q	95_G	2.187	1.00
350_Y	354_V	2.144	1.00
143_L	147_I	2.142	1.00
422_I	426_I	2.124	1.00
230_E	321_R	2.108	1.00
19_A	23_T	2.104	1.00
324_Y	328_C	2.098	1.00
19_A	237_N	2.097	1.00
142_F	349_L	2.094	1.00
189_G	192_N	2.082	1.00
453_T	456_G	2.081	1.00
22_L	231_S	2.039	1.00
150_R	154_E	2.013	1.00
139_G	357_G	1.997	1.00
240_R	244_Q	1.978	1.00
134_S	360_F	1.962	1.00
146_Y	346_R	1.956	1.00
23_T	248_R	1.955	1.00
18_K	21_H	1.931	1.00
161_L	165_T	1.931	1.00
419_L	423_F	1.930	1.00
330_G	334_R	1.917	1.00
90_V	395_R	1.906	1.00
87_Q	92_E	1.906	1.00
286_L	289_Q	1.900	1.00
13_L	339_L	1.895	1.00
68_S	390_A	1.893	1.00
135_A	360_F	1.893	1.00
268_D	290_H	1.874	1.00
60_L	64_F	1.863	1.00
265_P	268_D	1.856	1.00
103_W	352_T	1.840	1.00
336_F	351_A	1.840	1.00
243_R	247_W	1.824	1.00
42_T	51_A	1.817	1.00
391_I	425_F	1.786	1.00
90_V	391_I	1.780	1.00
426_I	430_I	1.772	1.00
464_W	468_K	1.742	1.00
340_S	344_V	1.735	1.00
139_G	353_T	1.735	1.00
233_D	237_N	1.734	1.00
280_S	286_L	1.706	1.00
145_N	313_N	1.698	1.00
21_H	157_Y	1.658	1.00
98_L	388_G	1.655	1.00
86_G	98_L	1.646	1.00
165_T	169_V	1.640	1.00
26_A	245_V	1.619	1.00
91_E	94_F	1.618	1.00
460_F	463_I	1.618	1.00
54_S	210_V	1.615	1.00
247_W	251_L	1.614	1.00
146_Y	350_Y	1.601	1.00
17_L	21_H	1.589	1.00
342_G	346_R	1.587	1.00
61_M	427_L	1.568	1.00
395_R	398_R	1.562	1.00
114_L	312_G	1.561	1.00
138_L	356_A	1.549	1.00
64_F	423_F	1.542	1.00
233_D	240_R	1.541	1.00
286_L	290_H	1.532	1.00
190_W	193_W	1.519	1.00
110_I	356_A	1.512	1.00
454_Y	458_P	1.493	1.00
463_I	467_Y	1.489	1.00
121_M	133_W	1.480	1.00
166_T	303_V	1.473	1.00
347_N	351_A	1.468	1.00
49_G	200_F	1.467	1.00
147_I	342_G	1.465	1.00
114_L	138_L	1.461	1.00
459_L	463_I	1.460	1.00
227_A	317_Y	1.453	1.00
456_G	459_L	1.451	1.00
79_S	229_G	1.451	1.00
164_V	168_I	1.447	1.00
175_V	259_I	1.441	1.00
14_R	343_G	1.439	1.00
334_R	338_K	1.429	1.00
462_I	466_G	1.416	1.00
58_I	214_V	1.410	1.00
319_S	352_T	1.410	1.00
391_I	395_R	1.398	1.00
117_A	305_L	1.397	1.00
324_Y	339_L	1.395	1.00
323_L	348_A	1.395	1.00
135_A	139_G	1.394	1.00
86_G	388_G	1.377	1.00
138_L	353_T	1.371	1.00
289_Q	297_A	1.367	1.00
406_D	410_L	1.358	1.00
90_V	94_F	1.354	1.00
66_M	246_F	1.350	1.00
128_T	131_W	1.349	1.00
458_P	462_I	1.339	1.00
60_L	423_F	1.336	1.00
338_K	346_R	1.329	1.00
334_R	337_A	1.327	1.00
465_F	469_L	1.324	1.00
142_F	350_Y	1.320	1.00
298_A	302_A	1.312	1.00
17_L	22_L	1.310	1.00
13_L	324_Y	1.308	1.00
456_G	463_I	1.305	1.00
320_T	349_L	1.298	1.00
117_A	137_F	1.296	1.00
455_I	459_L	1.280	1.00
21_H	153_G	1.268	1.00
282_S	286_L	1.267	1.00
251_L	255_F	1.267	1.00
407_I	410_L	1.266	1.00
76_M	88_N	1.264	1.00
234_P	239_P	1.248	1.00
461_L	465_F	1.248	1.00
66_M	242_V	1.248	1.00
19_A	240_R	1.248	1.00
20_R	24_M	1.246	1.00
68_S	421_P	1.245	1.00
30_S	249_I	1.233	1.00
89_Y	392_S	1.233	1.00
323_L	332_A	1.229	1.00
65_L	390_A	1.227	1.00
67_T	243_R	1.216	1.00
17_L	153_G	1.215	1.00
416_F	420_G	1.214	1.00
113_D	311_A	1.213	1.00
178_I	262_L	1.209	1.00
141_I	312_G	1.207	1.00
237_N	240_R	1.206	1.00
22_L	241_A	1.206	1.00
37_V	116_A	1.203	1.00
171_I	255_F	1.196	1.00
144_L	155_A	1.195	1.00
52_L	258_L	1.193	1.00
75_Y	410_L	1.187	1.00
456_G	464_W	1.186	1.00
84_T	88_N	1.181	1.00
463_I	466_G	1.161	1.00
387_L	429_L	1.159	1.00
453_T	460_F	1.158	1.00
155_A	159_F	1.147	1.00
418_P	422_I	1.145	1.00
132_I	136_L	1.143	1.00
174_G	263_I	1.139	1.00
26_A	224_I	1.138	1.00
430_I	434_G	1.133	1.00
93_G	467_Y	1.133	1.00
175_V	179_I	1.133	1.00
394_Y	422_I	1.129	1.00
103_W	323_L	1.125	1.00
419_L	422_I	1.123	1.00
189_G	193_W	1.117	1.00
25_I	227_A	1.110	1.00
408_N	411_P	1.110	1.00
49_G	207_M	1.110	1.00
289_Q	294_L	1.108	1.00
69_L	82_F	1.104	1.00
27_I	248_R	1.101	1.00
78_V	84_T	1.100	1.00
466_G	469_L	1.100	1.00
168_I	172_I	1.100	1.00
266_Y	269_P	1.099	1.00
88_N	400_Y	1.096	1.00
280_S	283_P	1.094	1.00
136_L	140_V	1.091	1.00
169_V	173_V	1.087	1.00
170_F	174_G	1.085	1.00
96_F	100_W	1.084	1.00
43_I	51_A	1.084	1.00
83_A	325_T	1.080	1.00
464_W	467_Y	1.080	1.00
100_W	460_F	1.073	1.00
439_A	442_K	1.066	1.00
339_L	343_G	1.063	1.00
347_N	350_Y	1.063	1.00
425_F	429_L	1.058	1.00
73_A	85_Y	1.056	1.00
16_E	232_E	1.052	1.00
156_E	313_N	1.048	1.00
410_L	413_R	1.048	1.00
232_E	237_N	1.040	1.00
56_M	254_V	1.038	1.00
203_G	206_A	1.038	1.00
139_G	143_L	1.036	1.00
64_F	420_G	1.033	1.00
354_V	358_L	1.033	1.00
154_E	158_W	1.032	1.00
436_N	439_A	1.030	1.00
176_L	181_I	1.028	1.00
429_L	433_L	1.028	1.00
457_I	460_F	1.027	1.00
208_I	430_I	1.023	1.00
328_C	337_A	1.015	1.00
187_P	190_W	1.011	1.00
265_P	290_H	1.010	1.00
393_H	421_P	1.007	1.00
387_L	428_C	1.002	1.00
142_F	146_Y	0.999	1.00
452_A	456_G	0.994	1.00
71_E	74_A	0.985	1.00
27_I	249_I	0.983	1.00
149_V	317_Y	0.982	1.00
398_R	418_P	0.980	1.00
146_Y	344_V	0.980	1.00
228_A	238_I	0.979	1.00
78_V	88_N	0.978	1.00
46_A	49_G	0.977	1.00
200_F	207_M	0.974	1.00
146_Y	340_S	0.963	1.00
458_P	461_L	0.963	1.00
191_S	194_T	0.959	1.00
195_I	198_A	0.959	1.00
416_F	419_L	0.957	1.00
417_F	421_P	0.956	1.00
121_M	305_L	0.956	1.00
164_V	252_F	0.955	1.00
86_G	94_F	0.954	1.00
176_L	180_G	0.951	1.00
121_M	125_F	0.949	1.00
56_M	60_L	0.948	1.00
219_Q	382_G	0.948	1.00
456_G	461_L	0.948	1.00
457_I	461_L	0.937	1.00
222_E	226_I	0.937	1.00
436_N	440_F	0.935	1.00
118_Q	133_W	0.929	1.00
80_G	84_T	0.928	1.00
316_M	353_T	0.925	1.00
159_F	310_S	0.924	1.00
244_Q	248_R	0.924	1.00
452_A	459_L	0.923	1.00
263_I	287_V	0.919	1.00
171_I	259_I	0.919	1.00
459_L	462_I	0.918	1.00
163_K	307_A	0.916	1.00
294_L	298_A	0.916	1.00
75_Y	408_N	0.916	1.00
118_Q	134_S	0.914	1.00
453_T	457_I	0.913	1.00
424_A	428_C	0.907	1.00
59_G	218_F	0.901	1.00
87_Q	329_D	0.901	1.00
16_E	150_R	0.900	1.00
387_L	391_I	0.899	1.00
464_W	469_L	0.895	1.00
52_L	261_S	0.894	1.00
24_M	157_Y	0.892	1.00
346_R	350_Y	0.890	1.00
400_Y	407_I	0.889	1.00
74_A	411_P	0.886	1.00
141_I	313_N	0.884	1.00
293_L	296_A	0.883	1.00
91_E	468_K	0.881	1.00
336_F	347_N	0.880	1.00
250_L	254_V	0.877	1.00
170_F	288_F	0.877	1.00
31_I	34_G	0.874	1.00
112_V	375_L	0.872	1.00
140_V	309_L	0.871	1.00
340_S	343_G	0.870	1.00
461_L	464_W	0.870	1.00
292_G	296_A	0.867	1.00
390_A	425_F	0.866	1.00
332_A	336_F	0.865	1.00
432_T	440_F	0.864	1.00
200_F	203_G	0.862	1.00
459_L	467_Y	0.862	1.00
454_Y	459_L	0.860	1.00
129_P	132_I	0.858	1.00
409_D	412_Y	0.857	1.00
65_L	428_C	0.851	1.00
112_V	216_F	0.849	1.00
117_A	308_V	0.845	1.00
86_G	392_S	0.843	1.00
100_W	332_A	0.842	1.00
19_A	241_A	0.837	1.00
49_G	199_P	0.836	1.00
458_P	463_I	0.835	1.00
175_V	255_F	0.834	1.00
192_N	195_I	0.830	1.00
179_I	187_P	0.830	1.00
408_N	413_R	0.829	1.00
21_H	154_E	0.828	1.00
433_L	437_Y	0.828	1.00
63_Y	67_T	0.827	1.00
353_T	357_G	0.827	1.00
190_W	262_L	0.820	1.00
117_A	309_L	0.819	1.00
288_F	293_L	0.818	1.00
20_R	157_Y	0.818	1.00
171_I	175_V	0.815	1.00
133_W	136_L	0.815	1.00
13_L	321_R	0.814	1.00
209_G	213_I	0.807	1.00
460_F	468_K	0.806	1.00
412_Y	415_G	0.804	1.00
394_Y	421_P	0.804	1.00
197_E	200_F	0.804	1.00
454_Y	457_I	0.803	1.00
400_Y	406_D	0.803	1.00
453_T	458_P	0.802	1.00
190_W	194_T	0.800	1.00
138_L	360_F	0.800	1.00
409_D	413_R	0.795	1.00
53_L	207_M	0.795	1.00
80_G	83_A	0.793	1.00
455_I	460_F	0.793	1.00
154_E	157_Y	0.792	1.00
453_T	459_L	0.792	1.00
115_V	374_L	0.791	1.00
438_E	442_K	0.791	1.00
141_I	316_M	0.790	1.00
75_Y	406_D	0.790	1.00
223_L	318_A	0.790	1.00
63_Y	243_R	0.786	1.00
118_Q	121_M	0.785	1.00
189_G	194_T	0.783	1.00
128_T	132_I	0.782	1.00
258_L	262_L	0.780	1.00
143_L	146_Y	0.780	1.00
453_T	464_W	0.775	1.00
455_I	458_P	0.773	1.00
31_I	163_K	0.773	1.00
13_L	230_E	0.772	1.00
178_I	259_I	0.770	1.00
451_A	454_Y	0.767	1.00
431_I	435_Q	0.766	1.00
394_Y	418_P	0.766	1.00
219_Q	386_W	0.759	1.00
400_Y	410_L	0.756	1.00
282_S	285_T	0.755	1.00
406_D	409_D	0.754	1.00
432_T	435_Q	0.753	1.00
204_F	207_M	0.751	1.00
72_L	85_Y	0.750	1.00
72_L	393_H	0.746	1.00
64_F	68_S	0.745	1.00
393_H	397_R	0.741	1.00
463_I	469_L	0.741	1.00
283_P	287_V	0.740	1.00
354_V	357_G	0.738	1.00
93_G	97_A	0.738	1.00
233_D	239_P	0.734	1.00
53_L	57_L	0.732	1.00
23_T	241_A	0.730	1.00
109_T	378_S	0.730	1.00
239_P	242_V	0.729	1.00
102_Y	106_W	0.728	1.00
377_T	381_T	0.723	1.00
94_F	388_G	0.723	1.00
48_P	261_S	0.720	1.00
20_R	23_T	0.720	1.00
107_A	355_I	0.719	1.00
171_I	256_A	0.716	1.00
147_I	151_G	0.715	1.00
35_L	256_A	0.714	1.00
415_G	419_L	0.714	1.00
460_F	467_Y	0.712	1.00
188_A	191_S	0.711	1.00
90_V	392_S	0.709	1.00
101_N	385_A	0.707	1.00
145_N	349_L	0.707	1.00
394_Y	398_R	0.705	1.00
418_P	421_P	0.704	1.00
89_Y	395_R	0.703	1.00
198_A	201_A	0.700	1.00
16_E	149_V	0.699	1.00
283_P	288_F	0.698	1.00
284_F	288_F	0.696	1.00
407_I	411_P	0.696	1.00
430_I	433_L	0.690	1.00
30_S	245_V	0.688	1.00
457_I	464_W	0.687	1.00
279_I	283_P	0.687	1.00
452_A	455_I	0.686	1.00
244_Q	247_W	0.685	1.00
288_F	291_A	0.680	1.00
321_R	324_Y	0.680	1.00
83_A	87_Q	0.678	1.00
392_S	396_F	0.677	1.00
335_I	351_A	0.677	1.00
295_S	298_A	0.676	1.00
255_F	259_I	0.676	1.00
153_G	157_Y	0.676	1.00
400_Y	408_N	0.676	1.00
452_A	460_F	0.675	1.00
187_P	191_S	0.674	1.00
20_R	154_E	0.673	1.00
31_I	252_F	0.672	1.00
146_Y	342_G	0.671	1.00
105_N	382_G	0.670	1.00
406_D	411_P	0.668	1.00
414_S	417_F	0.668	1.00
53_L	56_M	0.668	1.00
229_G	324_Y	0.667	1.00
89_Y	396_F	0.666	1.00
162_I	303_V	0.664	1.00
64_F	424_A	0.664	1.00
135_A	361_L	0.664	1.00
323_L	351_A	0.663	1.00
452_A	461_L	0.660	1.00
109_T	112_V	0.657	1.00
208_I	434_G	0.654	1.00
316_M	320_T	0.654	1.00
62_V	221_T	0.654	1.00
341_R	346_R	0.653	1.00
131_W	135_A	0.652	1.00
162_I	166_T	0.650	1.00
428_C	431_I	0.648	1.00
82_F	222_E	0.647	1.00
108_V	377_T	0.646	1.00
66_M	221_T	0.646	1.00
283_P	286_L	0.645	1.00
151_G	154_E	0.644	1.00
109_T	113_D	0.644	1.00
435_Q	439_A	0.644	1.00
72_L	89_Y	0.643	1.00
320_T	348_A	0.641	1.00
32_G	36_F	0.641	1.00
336_F	348_A	0.640	1.00
235_A	409_D	0.639	1.00
83_A	99_G	0.639	1.00
146_Y	349_L	0.639	1.00
69_L	389_I	0.638	1.00
124_W	302_A	0.637	1.00
394_Y	425_F	0.635	1.00
79_S	324_Y	0.635	1.00
381_T	385_A	0.634	1.00
111_A	359_C	0.634	1.00
145_N	317_Y	0.633	1.00
319_S	323_L	0.633	1.00
137_F	312_G	0.628	1.00
248_R	252_F	0.628	1.00
279_I	282_S	0.627	1.00
28_G	160_S	0.627	1.00
38_A	375_L	0.627	1.00
141_I	309_L	0.625	1.00
16_E	20_R	0.625	1.00
111_A	374_L	0.625	1.00
81_S	225_G	0.624	1.00
153_G	313_N	0.623	1.00
248_R	251_L	0.623	1.00
433_L	436_N	0.623	1.00
193_W	261_S	0.622	1.00
307_A	310_S	0.622	1.00
436_N	441_L	0.619	1.00
68_S	424_A	0.618	1.00
52_L	254_V	0.617	1.00
417_F	420_G	0.616	1.00
140_V	144_L	0.616	1.00
452_A	463_I	0.615	1.00
52_L	56_M	0.615	1.00
176_L	179_I	0.614	1.00
188_A	192_N	0.612	1.00
117_A	121_M	0.612	1.00
138_L	357_G	0.612	1.00
57_L	211_A	0.611	1.00
200_F	204_F	0.609	1.00
31_I	36_F	0.609	1.00
51_A	257_I	0.608	1.00
421_P	425_F	0.607	1.00
73_A	225_G	0.606	1.00
238_I	242_V	0.605	1.00
219_Q	222_E	0.605	1.00
120_V	304_I	0.602	1.00
339_L	342_G	0.602	1.00
113_D	116_A	0.599	1.00
302_A	306_T	0.597	1.00
256_A	260_I	0.597	1.00
149_V	227_A	0.596	1.00
345_P	348_A	0.595	1.00
29_G	315_G	0.595	1.00
91_E	95_G	0.593	1.00
29_G	314_S	0.591	1.00
136_L	139_G	0.591	1.00
231_S	238_I	0.590	1.00
151_G	155_A	0.589	1.00
83_A	95_G	0.588	1.00
206_A	209_G	0.587	1.00
39_S	257_I	0.585	1.00
58_I	218_F	0.584	1.00
70_G	74_A	0.584	1.00
458_P	464_W	0.584	1.00
23_T	26_A	0.583	1.00
225_G	242_V	0.581	1.00
453_T	461_L	0.581	1.00
459_L	464_W	0.580	1.00
142_F	316_M	0.580	1.00
121_M	137_F	0.579	1.00
157_Y	161_L	0.578	1.00
73_A	238_I	0.578	1.00
380_M	432_T	0.578	1.00
226_I	318_A	0.577	1.00
284_F	287_V	0.577	1.00
82_F	226_I	0.577	1.00
139_G	142_F	0.576	1.00
453_T	467_Y	0.575	1.00
316_M	349_L	0.574	1.00
387_L	432_T	0.574	1.00
111_A	356_A	0.574	1.00
173_V	177_M	0.571	1.00
55_Y	217_S	0.570	1.00
426_I	429_L	0.569	1.00
106_W	315_G	0.569	1.00
323_L	327_A	0.567	1.00
71_E	415_G	0.566	1.00
460_F	465_F	0.566	1.00
114_L	118_Q	0.565	1.00
451_A	464_W	0.565	1.00
327_A	336_F	0.564	1.00
287_V	291_A	0.564	1.00
461_L	467_Y	0.563	1.00
396_F	400_Y	0.563	1.00
189_G	262_L	0.562	1.00
139_G	350_Y	0.562	1.00
465_F	468_K	0.562	1.00
86_G	95_G	0.561	1.00
372_L	375_L	0.561	1.00
123_W	301_N	0.560	1.00
29_G	223_L	0.559	1.00
27_I	160_S	0.558	1.00
410_L	414_S	0.557	1.00
424_A	427_L	0.556	1.00
423_F	426_I	0.555	1.00
113_D	308_V	0.555	1.00
283_P	291_A	0.555	1.00
197_E	201_A	0.555	1.00
124_W	301_N	0.553	1.00
160_S	163_K	0.553	1.00
157_Y	160_S	0.552	1.00
158_W	161_L	0.551	1.00
397_R	417_F	0.550	1.00
58_I	215_G	0.550	1.00
235_A	240_R	0.550	1.00
13_L	16_E	0.549	1.00
67_T	420_G	0.549	1.00
187_P	193_W	0.547	1.00
98_L	385_A	0.546	1.00
421_P	435_Q	0.546	1.00
63_Y	247_W	0.546	1.00
299_V	303_V	0.545	1.00
41_A	44_S	0.544	1.00
26_A	30_S	0.543	1.00
90_V	93_G	0.543	1.00
259_I	262_L	0.543	1.00
42_T	46_A	0.542	1.00
222_E	386_W	0.542	1.00
137_F	309_L	0.541	1.00
406_D	413_R	0.541	1.00
25_I	28_G	0.540	1.00
113_D	312_G	0.540	1.00
188_A	194_T	0.540	1.00
361_L	364_M	0.538	1.00
351_A	355_I	0.536	1.00
122_S	130_G	0.535	1.00
148_S	151_G	0.533	1.00
456_G	468_K	0.533	1.00
93_G	461_L	0.532	1.00
248_R	255_F	0.532	1.00
234_P	237_N	0.532	1.00
66_M	70_G	0.532	1.00
438_E	441_L	0.530	1.00
187_P	192_N	0.529	1.00
219_Q	378_S	0.525	1.00
195_I	201_A	0.524	1.00
75_Y	411_P	0.524	1.00
42_T	214_V	0.523	1.00
52_L	55_Y	0.523	1.00
166_T	299_V	0.522	1.00
460_F	469_L	0.522	1.00
358_L	361_L	0.521	1.00
22_L	237_N	0.520	1.00
107_A	352_T	0.519	1.00
162_I	306_T	0.518	1.00
231_S	241_A	0.517	1.00
41_A	372_L	0.517	1.00
270_S	280_S	0.515	1.00
428_C	432_T	0.514	1.00
195_I	199_P	0.514	1.00
383_F	428_C	0.513	1.00
152_F	317_Y	0.513	1.00
288_F	296_A	0.512	1.00
415_G	420_G	0.512	1.00
24_M	160_S	0.511	1.00
125_F	133_W	0.511	1.00
421_P	424_A	0.511	1.00
407_I	413_R	0.510	1.00
137_F	141_I	0.509	1.00
452_A	458_P	0.509	1.00
75_Y	396_F	0.508	1.00
459_L	466_G	0.508	1.00
18_K	150_R	0.508	1.00
457_I	463_I	0.508	1.00
224_I	242_V	0.507	1.00
235_A	411_P	0.507	1.00
140_V	143_L	0.506	1.00
452_A	457_I	0.506	1.00
39_S	42_T	0.506	1.00
456_G	467_Y	0.505	1.00
40_G	43_I	0.505	1.00
226_I	322_M	0.504	1.00
54_S	57_L	0.504	1.00
48_P	52_L	0.504	1.00
230_E	345_P	0.503	1.00
55_Y	253_Y	0.503	1.00
451_A	456_G	0.502	1.00
224_I	238_I	0.502	1.00
65_L	222_E	0.501	1.00
264_I	268_D	0.500	1.00
70_G	242_V	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3l1lA	2	0.8528	100	0.342	Contact Map
3giaA	1	0.8753	100	0.382	Contact Map
4djkA	2	0.8609	100	0.385	Contact Map
3dh4A	3	0.8978	99.1	0.852	Contact Map
2xq2A	2	0.8998	99.1	0.858	Contact Map
2jlnA	1	0.8589	99	0.863	Contact Map
4wgvA	2	0.7607	97.4	0.909	Contact Map
4xp4A	1	0.91	96.8	0.918	Contact Map
2a65A	2	0.8998	95.8	0.925	Contact Map
4us3A	1	0.8078	94.2	0.932	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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