GREMLIN Database
END1 - Endonuclease-1
UniProt: P25736 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11336
Length: 235 (216)
Sequences: 1188 (849)
Seq/√Len: 57.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
166_A169_R5.0251.00
171_A202_Y4.1961.00
206_D210_E3.6831.00
109_D116_E3.2831.00
123_Q175_T3.2491.00
163_E169_R2.8161.00
197_A201_M2.7891.00
212_D222_H2.7201.00
181_D225_Y2.6111.00
140_Q197_A2.5901.00
128_E132_D2.4801.00
189_R193_Q2.4041.00
119_M215_I2.3141.00
222_H227_Q2.2801.00
18_G21_L2.2241.00
89_W93_H2.2241.00
15_A18_G2.1871.00
109_D112_Y2.1681.00
136_F157_F1.9961.00
26_N34_A1.9621.00
109_D113_R1.9381.00
165_P168_A1.9101.00
22_A34_A1.8350.99
153_M162_A1.8320.99
211_R215_I1.7800.99
212_D227_Q1.7610.99
112_Y115_M1.7440.99
67_G71_R1.6940.99
120_H123_Q1.6850.99
36_V40_A1.6840.99
16_F21_L1.6790.99
106_C172_I1.6750.99
120_H212_D1.6630.99
15_A21_L1.6580.99
209_C213_E1.6270.99
216_A220_G1.6070.99
50_C122_L1.6030.99
68_Y71_R1.5990.99
139_S161_A1.5830.98
177_F195_F1.5640.98
110_P113_R1.5470.98
202_Y205_T1.5440.98
57_K119_M1.5400.98
90_Q93_H1.5120.98
192_T196_N1.4850.98
63_L66_C1.4720.98
26_N30_Q1.4670.98
76_R79_R1.4520.97
171_A205_T1.4420.97
77_A81_E1.4310.97
46_F123_Q1.3790.96
151_C155_V1.3760.96
69_Q73_N1.3680.96
210_E214_R1.3510.96
180_R187_L1.3470.96
35_A119_M1.3440.96
92_G95_R1.3390.96
99_Q128_E1.3310.96
228_R231_Q1.3260.95
72_K172_I1.2970.95
60_V70_V1.2840.95
79_R83_E1.2750.94
210_E213_E1.2710.94
120_H211_R1.2710.94
53_N57_K1.2660.94
120_H175_T1.2580.94
18_G22_A1.2560.94
206_D209_C1.2530.94
121_N175_T1.2480.94
196_N199_N1.2440.94
66_C71_R1.2420.94
88_A91_F1.2250.93
167_R205_T1.2210.93
107_A112_Y1.2160.93
88_A92_G1.2070.93
58_K61_V1.2020.92
34_A37_K1.1960.92
148_Y151_C1.1950.92
23_E26_N1.1900.92
81_E84_H1.1880.92
37_K40_A1.1820.92
100_D127_G1.1800.92
149_G152_A1.1730.91
113_R116_E1.1670.91
107_A110_P1.1620.91
133_R138_Y1.1510.91
170_G174_R1.1430.90
109_D179_M1.1320.90
99_Q147_Q1.1260.90
185_L188_S1.1140.89
216_A222_H1.1020.89
214_R218_V1.0960.88
212_D226_V1.0940.88
77_A82_W1.0790.88
81_E85_V1.0760.87
212_D216_A1.0700.87
94_Q99_Q1.0620.87
68_Y73_N1.0610.87
54_W122_L1.0610.87
56_G218_V1.0540.86
106_C109_D1.0540.86
207_W210_E1.0400.86
28_F31_A1.0400.86
103_R179_M1.0260.85
172_I176_Y1.0170.84
82_W85_V1.0170.84
105_N110_P1.0120.84
77_A83_E1.0120.84
116_E179_M1.0050.84
76_R83_E0.9990.83
177_F204_V0.9910.83
93_H96_Q0.9790.82
96_Q99_Q0.9770.82
180_R192_T0.9770.82
32_K184_N0.9740.82
111_V176_Y0.9670.81
121_N179_M0.9640.81
92_G99_Q0.9630.81
67_G73_N0.9620.81
111_V137_M0.9610.81
85_V88_A0.9600.81
96_Q100_D0.9450.80
196_N200_K0.9440.80
119_M218_V0.9420.79
197_A200_K0.9420.79
190_Q194_L0.9370.79
181_D184_N0.9360.79
94_Q127_G0.9360.79
106_C176_Y0.9330.79
84_H88_A0.9250.78
164_P194_L0.9210.78
102_G106_C0.9170.78
23_E34_A0.9090.77
92_G127_G0.9060.77
112_Y121_N0.9060.77
187_L195_F0.9050.77
33_A37_K0.9050.77
106_C175_T0.9050.77
168_A202_Y0.9050.77
52_I55_Q0.8930.76
118_D178_Y0.8890.75
78_S83_E0.8860.75
50_C54_W0.8830.75
199_N217_K0.8780.74
21_L26_N0.8770.74
141_W144_G0.8770.74
102_G112_Y0.8760.74
66_C69_Q0.8760.74
103_R106_C0.8740.74
138_Y176_Y0.8740.74
163_E166_A0.8670.73
92_G100_D0.8660.73
180_R225_Y0.8650.73
55_Q58_K0.8590.73
76_R81_E0.8480.72
109_D114_K0.8420.71
76_R82_W0.8340.71
168_A171_A0.8290.70
84_H87_P0.8250.70
78_S81_E0.8240.70
30_Q34_A0.8200.69
102_G109_D0.8070.68
163_E177_F0.8070.68
128_E147_Q0.8050.68
19_P25_I0.7970.67
116_E122_L0.7970.67
62_D70_V0.7960.67
106_C123_Q0.7940.67
98_W128_E0.7930.67
181_D224_P0.7910.66
105_N108_K0.7880.66
63_L67_G0.7850.66
81_E88_A0.7760.65
50_C66_C0.7720.65
79_R82_W0.7710.64
138_Y172_I0.7710.64
32_K181_D0.7710.64
102_G110_P0.7670.64
118_D219_Q0.7650.64
91_F100_D0.7640.64
85_V175_T0.7620.64
83_E88_A0.7590.63
60_V66_C0.7570.63
152_A167_R0.7570.63
166_A171_A0.7560.63
104_K108_K0.7480.62
54_W59_G0.7470.62
50_C55_Q0.7450.62
107_A111_V0.7420.61
53_N119_M0.7420.61
20_A23_E0.7410.61
182_Q203_P0.7380.61
56_G214_R0.7370.61
17_S21_L0.7350.61
21_L30_Q0.7260.60
90_Q94_Q0.7240.60
108_K189_R0.7240.60
222_H226_V0.7150.59
89_W92_G0.7110.58
213_E217_K0.7080.58
93_H99_Q0.7060.58
140_Q201_M0.7050.58
91_F127_G0.7040.57
141_W202_Y0.7040.57
53_N218_V0.7010.57
138_Y162_A0.6970.57
132_D148_Y0.6940.56
84_H92_G0.6890.56
92_G96_Q0.6870.56
44_G117_S0.6870.56
109_D121_N0.6860.55
177_F225_Y0.6830.55
21_L24_G0.6820.55
19_P34_A0.6800.55
39_H182_Q0.6760.54
208_E226_V0.6760.54
60_V65_S0.6690.54
15_A19_P0.6680.54
24_G37_K0.6680.54
87_P92_G0.6670.53
214_R220_G0.6660.53
177_F196_N0.6650.53
141_W163_E0.6620.53
115_M121_N0.6600.53
23_E38_V0.6580.52
95_R127_G0.6570.52
46_F117_S0.6560.52
207_W214_R0.6520.52
57_K215_I0.6520.52
120_H219_Q0.6510.52
122_L135_N0.6490.51
24_G34_A0.6480.51
108_K138_Y0.6480.51
137_M161_A0.6460.51
95_R99_Q0.6380.50
107_A179_M0.6340.50
102_G133_R0.6300.49
18_G24_G0.6290.49
19_P222_H0.6280.49
56_G217_K0.6220.48
21_L34_A0.6200.48
105_N222_H0.6200.48
79_R85_V0.6200.48
63_L70_V0.6190.48
157_F220_G0.6190.48
107_A113_R0.6140.48
19_P30_Q0.6120.47
107_A168_A0.6060.47
33_A186_T0.6040.46
136_F160_K0.5960.46
80_V84_H0.5940.45
106_C116_E0.5940.45
88_A98_W0.5930.45
126_V139_S0.5920.45
215_I219_Q0.5910.45
16_F19_P0.5880.45
63_L71_R0.5830.44
19_P23_E0.5820.44
76_R85_V0.5820.44
175_T194_L0.5800.44
109_D122_L0.5800.44
91_F98_W0.5790.44
49_G56_G0.5780.44
120_H131_G0.5780.44
29_S33_A0.5760.43
79_R84_H0.5750.43
63_L68_Y0.5710.43
97_C106_C0.5710.43
176_Y189_R0.5710.43
73_N81_E0.5700.43
171_A225_Y0.5680.43
29_S122_L0.5680.43
180_R184_N0.5660.42
75_N79_R0.5620.42
46_F49_G0.5610.42
187_L193_Q0.5610.42
95_R98_W0.5610.42
17_S24_G0.5560.41
125_S188_S0.5550.41
33_A231_Q0.5530.41
105_N227_Q0.5530.41
136_F204_V0.5500.41
153_M165_P0.5500.41
115_M187_L0.5500.41
162_A195_F0.5500.41
167_R171_A0.5470.40
149_G157_F0.5470.40
127_G134_G0.5450.40
145_E162_A0.5450.40
67_G72_K0.5420.40
177_F192_T0.5410.40
104_K222_H0.5400.40
26_N201_M0.5380.39
51_K58_K0.5370.39
95_R131_G0.5320.39
49_G55_Q0.5310.39
93_H127_G0.5310.39
174_R208_E0.5310.39
76_R84_H0.5300.39
80_V83_E0.5300.39
36_V41_D0.5290.38
221_N225_Y0.5270.38
82_W87_P0.5260.38
127_G131_G0.5260.38
15_A25_I0.5250.38
143_G152_A0.5220.38
51_K90_Q0.5210.38
151_C157_F0.5200.37
191_Q204_V0.5200.37
70_V73_N0.5190.37
85_V90_Q0.5160.37
32_K38_V0.5150.37
129_V164_P0.5100.36
152_A205_T0.5080.36
16_F20_A0.5050.36
170_G208_E0.5050.36
125_S162_A0.5040.36
19_P31_A0.5030.36
84_H127_G0.5030.36
177_F181_D0.5030.36
111_V228_R0.5030.36
182_Q199_N0.5020.36
109_D175_T0.5020.36
83_E93_H0.5000.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2pu3A 1 0.8681 100 0.225 Contact Map
3m7kA 2 0.5106 30.3 0.959 Contact Map
4h9dA 3 0.4128 4.8 0.972 Contact Map
4p6kA 2 0.0638 3.4 0.974 Contact Map
2mfqB 1 0.0979 3.4 0.974 Contact Map
1no1A 1 0.2766 3.3 0.974 Contact Map
4kt3B 1 0.2511 3.2 0.974 Contact Map
2zc2A 1 0.2383 3 0.974 Contact Map
2i39A 2 0.2085 3 0.974 Contact Map
3ro2B 1 0.0936 2.9 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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