GREMLIN Database
AMY1 - Alpha-amylase
UniProt: P25718 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11316
Length: 676 (551)
Sequences: 198 (140)
Seq/√Len: 5.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
297_V454_I4.2970.96
203_D229_R4.2480.95
299_S302_Q3.9190.93
229_R292_D3.8160.92
150_Q154_V3.2950.84
169_G173_L3.2030.82
201_N207_D3.0030.78
140_G144_R2.9770.77
157_G173_L2.9580.77
143_V147_Y2.8390.73
140_G143_V2.8290.73
169_G172_L2.7620.71
144_R147_Y2.5760.65
301_H455_D2.5750.65
149_Q155_K2.5740.65
156_N162_Q2.5720.65
155_K159_I2.5400.64
590_F626_S2.4910.63
102_T106_S2.4630.62
154_V157_G2.4620.62
169_G174_E2.4310.61
157_G163_P2.4190.60
238_L243_V2.3430.58
289_N292_D2.3420.58
170_L173_L2.3170.57
168_N173_L2.3120.57
164_A173_L2.2900.56
611_R616_W2.2890.56
157_G160_M2.2790.55
154_V161_L2.2750.55
149_Q163_P2.2500.54
228_L448_W2.1710.52
231_L248_I2.1470.51
203_D292_D2.0980.49
239_Q472_Q2.0550.48
163_P173_L2.0550.48
155_K160_M2.0410.47
163_P172_L2.0340.47
154_V160_M2.0180.46
140_G148_S2.0080.46
101_P107_I2.0030.46
144_R148_S1.9890.45
159_I172_L1.9880.45
570_R596_S1.9700.45
170_L174_E1.9660.44
243_V390_D1.9450.44
106_S110_A1.9440.44
167_S172_L1.9410.44
154_V159_I1.9390.44
230_G273_H1.9300.43
157_G174_E1.9180.43
333_Y336_G1.9010.42
154_V163_P1.9000.42
152_A155_K1.8930.42
227_D230_G1.8880.42
296_L307_I1.8810.42
561_L576_A1.8570.41
154_V158_Q1.8560.41
198_R230_G1.8290.40
282_N628_A1.8280.40
202_G237_Y1.8260.40
159_I173_L1.8190.39
140_G146_Y1.8180.39
167_S173_L1.8100.39
143_V148_S1.8030.39
142_A147_Y1.7960.39
187_H567_R1.7910.38
310_D458_R1.7910.38
158_Q163_P1.7600.37
150_Q156_N1.7570.37
417_L424_K1.7480.37
102_T107_I1.7400.37
299_S303_R1.7400.37
140_G145_D1.7370.37
274_G464_H1.7250.36
295_T302_Q1.7220.36
635_Q639_R1.7210.36
124_W133_V1.7180.36
143_V146_Y1.7110.36
198_R227_D1.7090.36
156_N159_I1.7070.36
227_D273_H1.7060.36
336_G341_K1.7010.36
393_G396_D1.6990.35
202_G236_D1.6900.35
417_L420_F1.6900.35
159_I164_A1.6700.35
155_K161_L1.6680.34
602_T609_G1.6670.34
250_A287_M1.6650.34
275_Y460_D1.6440.34
157_G161_L1.6440.34
158_Q173_L1.6420.34
164_A172_L1.6350.33
106_S109_N1.6330.33
154_V173_L1.6290.33
157_G169_G1.6270.33
198_R273_H1.6220.33
393_G398_T1.6160.33
196_T231_L1.6130.33
225_G288_G1.6130.33
249_S271_A1.6080.33
164_A167_S1.5980.32
193_F461_T1.5740.32
149_Q154_V1.5660.31
462_A542_D1.5640.31
163_P170_L1.5600.31
163_P169_G1.5590.31
140_G147_Y1.5580.31
591_Y646_G1.5550.31
149_Q152_A1.5500.31
295_T299_S1.5470.31
154_V164_A1.5460.31
103_L106_S1.5370.30
154_V162_Q1.5350.30
605_D611_R1.5120.30
269_H276_Y1.5060.29
273_H315_H1.5050.29
426_D429_A1.4960.29
247_W461_T1.4880.29
160_M173_L1.4860.29
274_G461_T1.4640.28
192_Y284_D1.4620.28
192_Y592_G1.4620.28
192_Y594_E1.4620.28
284_D592_G1.4620.28
284_D594_E1.4620.28
461_T464_H1.4540.28
247_W464_H1.4440.28
282_N346_R1.4430.28
164_A169_G1.4390.28
208_Q214_K1.4280.27
611_R614_M1.4250.27
152_A157_G1.4210.27
100_T106_S1.4200.27
155_K164_A1.4180.27
194_V316_T1.4100.27
167_S174_E1.4030.27
150_Q164_A1.4030.27
197_D225_G1.4020.27
190_T280_W1.3990.26
272_Y461_T1.3960.26
157_G172_L1.3930.26
333_Y341_K1.3830.26
246_L296_L1.3820.26
239_Q249_S1.3780.26
247_W274_G1.3770.26
154_V174_E1.3720.26
570_R573_G1.3600.25
167_S170_L1.3590.25
192_Y226_G1.3580.25
226_G284_D1.3580.25
226_G592_G1.3580.25
226_G594_E1.3580.25
155_K163_P1.3570.25
158_Q162_Q1.3540.25
202_G230_G1.3500.25
340_K344_G1.3490.25
116_S123_K1.3440.25
289_N632_K1.3410.25
280_W561_L1.3360.25
595_S615_N1.3350.25
198_R315_H1.3220.24
275_Y458_R1.3180.24
150_Q158_Q1.3150.24
227_D315_H1.3130.24
106_S111_A1.3110.24
155_K167_S1.3100.24
198_R202_G1.3100.24
346_R349_D1.3070.24
575_K634_S1.3050.24
332_L336_G1.3050.24
101_P106_S1.3040.24
193_F247_W1.3000.24
163_P174_E1.2980.24
298_D491_K1.2970.24
326_E329_F1.2940.24
230_G315_H1.2880.23
100_T105_I1.2750.23
344_G350_W1.2700.23
99_G102_T1.2690.23
250_A596_S1.2650.23
158_Q174_E1.2630.23
225_G448_W1.2620.23
101_P110_A1.2620.23
159_I169_G1.2510.23
315_H661_R1.2510.23
545_W626_S1.2490.23
248_I287_M1.2480.22
246_L283_L1.2450.22
164_A168_N1.2370.22
225_G593_D1.2340.22
275_Y310_D1.2260.22
310_D460_D1.2260.22
202_G227_D1.2090.22
315_H591_Y1.2090.22
288_G593_D1.2070.21
228_L293_L1.2050.21
333_Y339_V1.2040.21
150_Q159_I1.2030.21
155_K158_Q1.2030.21
273_H314_N1.2020.21
527_Y658_G1.1970.21
492_A495_D1.1930.21
524_N563_S1.1870.21
204_P239_Q1.1870.21
145_D148_S1.1860.21
332_L341_K1.1760.21
297_V633_I1.1760.21
603_G614_M1.1730.21
150_Q155_K1.1660.21
228_L292_D1.1660.21
205_S654_K1.1640.20
202_G273_H1.1630.20
426_D432_I1.1620.20
609_G612_S1.1590.20
198_R661_R1.1590.20
341_K344_G1.1580.20
107_I114_V1.1580.20
199_F227_D1.1570.20
503_E565_D1.1560.20
560_Y563_S1.1560.20
333_Y363_D1.1560.20
570_R595_S1.1460.20
606_P611_R1.1440.20
334_L338_E1.1380.20
150_Q163_P1.1370.20
472_Q476_E1.1320.20
101_P109_N1.1310.20
103_L107_I1.1300.20
567_R579_L1.1290.20
150_Q167_S1.1280.20
197_D288_G1.1270.20
207_D640_H1.1260.20
164_A174_E1.1260.20
156_N163_P1.1240.20
108_Q111_A1.1200.19
227_D661_R1.1180.19
439_D670_V1.1160.19
490_D493_L1.1150.19
199_F230_G1.1140.19
193_F274_G1.1050.19
199_F273_H1.1030.19
293_L582_L1.0990.19
626_S655_Q1.0950.19
518_G545_W1.0940.19
168_N174_E1.0940.19
199_F591_Y1.0940.19
249_S461_T1.0940.19
527_Y626_S1.0900.19
336_G339_V1.0850.19
97_R102_T1.0850.19
358_W361_F1.0840.19
420_F429_A1.0820.19
151_I162_Q1.0810.19
298_D475_T1.0770.19
117_L122_P1.0750.19
192_Y453_G1.0690.18
284_D453_G1.0690.18
453_G592_G1.0690.18
453_G594_E1.0690.18
139_E144_R1.0660.18
230_G237_Y1.0630.18
627_V660_V1.0590.18
542_D546_Q1.0560.18
217_M333_Y1.0560.18
139_E147_Y1.0560.18
158_Q172_L1.0550.18
154_V172_L1.0500.18
488_N491_K1.0490.18
355_G358_W1.0420.18
564_H661_R1.0420.18
163_P167_S1.0390.18
300_A307_I1.0380.18
570_R656_G1.0340.18
335_S338_E1.0340.18
250_A269_H1.0310.18
229_R289_N1.0300.18
344_G347_W1.0290.18
612_S616_W1.0270.18
322_A325_Q1.0260.17
193_F272_Y1.0250.17
373_W383_R1.0240.17
317_G519_F1.0210.17
253_E440_Y1.0190.17
345_E349_D1.0170.17
198_R314_N1.0130.17
406_D409_T1.0120.17
205_S649_T1.0110.17
315_H646_G1.0090.17
157_G168_N1.0070.17
193_F464_H1.0030.17
251_P269_H1.0030.17
611_R615_N1.0010.17
377_W439_D1.0000.17
117_L121_C1.0000.17
237_Y273_H1.0000.17
227_D314_N1.0000.17
193_F525_F0.9960.17
273_H661_R0.9920.17
102_T105_I0.9910.17
201_N288_G0.9910.17
315_H458_R0.9910.17
591_Y661_R0.9880.17
201_N225_G0.9840.17
347_W351_K0.9820.17
430_K433_D0.9820.17
492_A651_L0.9820.17
230_G314_N0.9810.17
519_F577_A0.9810.17
247_W272_Y0.9760.16
283_L571_E0.9720.16
347_W350_W0.9670.16
461_T525_F0.9670.16
288_G448_W0.9650.16
111_A118_V0.9640.16
226_G453_G0.9640.16
185_D229_R0.9610.16
237_Y661_R0.9610.16
154_V167_S0.9590.16
227_D237_Y0.9540.16
646_G661_R0.9530.16
100_T104_M0.9510.16
227_D591_Y0.9510.16
105_I109_N0.9510.16
125_D178_T0.9500.16
201_N593_D0.9470.16
195_L238_L0.9470.16
198_R237_Y0.9440.16
501_T558_L0.9440.16
100_T107_I0.9440.16
314_N661_R0.9390.16
97_R101_P0.9390.16
238_L589_I0.9390.16
185_D319_A0.9380.16
195_L468_P0.9320.16
228_L561_L0.9320.16
602_T606_P0.9320.16
190_T589_I0.9310.16
384_T488_N0.9310.16
234_K237_Y0.9280.16
227_D646_G0.9280.16
254_Q597_R0.9250.16
206_N661_R0.9250.16
310_D315_H0.9230.15
280_W344_G0.9220.15
150_Q157_G0.9220.15
195_L337_D0.9220.15
198_R591_Y0.9220.15
149_Q169_G0.9200.15
159_I174_E0.9170.15
98_S101_P0.9150.15
250_A280_W0.9140.15
157_G164_A0.9130.15
250_A275_Y0.9120.15
250_A460_D0.9120.15
159_I170_L0.9110.15
157_G162_Q0.9090.15
149_Q159_I0.9070.15
589_I606_P0.9070.15
272_Y464_H0.9060.15
101_P108_Q0.9060.15
230_G661_R0.9040.15
109_N114_V0.9020.15
313_M469_A0.9010.15
142_A145_D0.9010.15
243_V276_Y0.9010.15
541_M669_L0.9000.15
502_G590_F0.8990.15
117_L120_E0.8990.15
198_R646_G0.8980.15
370_K451_D0.8960.15
406_D410_E0.8960.15
312_V637_R0.8950.15
330_G333_Y0.8940.15
228_L582_L0.8930.15
346_R665_D0.8930.15
306_R558_L0.8840.15
511_Q570_R0.8840.15
283_L671_V0.8810.15
225_G611_R0.8790.15
567_R634_S0.8760.15
314_N591_Y0.8730.15
625_A632_K0.8710.15
107_I110_A0.8690.15
242_G503_E0.8690.15
242_G565_D0.8690.15
203_D287_M0.8680.14
313_M470_W0.8660.14
199_F458_R0.8660.14
226_G503_E0.8630.14
226_G565_D0.8630.14
401_L406_D0.8610.14
160_M169_G0.8600.14
334_L340_K0.8580.14
453_G637_R0.8560.14
131_V138_P0.8550.14
602_T605_D0.8530.14
150_Q172_L0.8520.14
243_V589_I0.8500.14
324_M329_F0.8500.14
134_S155_K0.8490.14
155_K170_L0.8450.14
275_Y315_H0.8440.14
315_H460_D0.8440.14
651_L669_L0.8440.14
424_K429_A0.8430.14
333_Y337_D0.8410.14
101_P104_M0.8410.14
410_E417_L0.8400.14
545_W658_G0.8400.14
353_A357_T0.8390.14
527_Y590_F0.8330.14
309_F567_R0.8310.14
168_N172_L0.8310.14
626_S658_G0.8310.14
273_H591_Y0.8290.14
606_P616_W0.8280.14
399_M404_L0.8280.14
334_L343_L0.8280.14
230_G236_D0.8270.14
199_F310_D0.8240.14
189_A584_P0.8210.14
110_A118_V0.8210.14
524_N616_W0.8200.14
202_G315_H0.8170.14
192_Y503_E0.8160.14
192_Y565_D0.8160.14
284_D503_E0.8160.14
284_D565_D0.8160.14
353_A360_S0.8160.14
503_E592_G0.8160.14
503_E594_E0.8160.14
565_D592_G0.8160.14
565_D594_E0.8160.14
156_N173_L0.8120.14
340_K343_L0.8080.13
412_T419_V0.8050.13
227_D590_F0.8030.13
138_P441_L0.8020.13
604_S615_N0.7980.13
426_D430_K0.7980.13
511_Q516_R0.7970.13
325_Q330_G0.7960.13
411_S414_A0.7910.13
334_L337_D0.7900.13
214_K282_N0.7890.13
469_A527_Y0.7870.13
153_I162_Q0.7870.13
445_L580_L0.7860.13
197_D448_W0.7860.13
160_M165_A0.7840.13
355_G631_Q0.7830.13
104_M112_E0.7790.13
160_M163_P0.7780.13
153_I156_N0.7780.13
196_T249_S0.7770.13
138_P143_V0.7770.13
248_I276_Y0.7770.13
342_S345_E0.7760.13
150_Q160_M0.7750.13
247_W525_F0.7740.13
168_N171_L0.7690.13
139_E142_A0.7690.13
331_A372_G0.7660.13
487_A490_D0.7660.13
352_P359_H0.7640.13
429_A432_I0.7640.13
596_S623_S0.7630.13
103_L112_E0.7600.13
227_D310_D0.7560.13
152_A156_N0.7550.13
150_Q162_Q0.7540.13
334_L344_G0.7540.13
616_W621_G0.7520.13
548_M551_K0.7480.13
195_L623_S0.7460.12
273_H646_G0.7450.12
288_G611_R0.7450.12
160_M170_L0.7440.12
603_G611_R0.7430.12
449_V670_V0.7420.12
198_R590_F0.7410.12
238_L280_W0.7410.12
647_K662_E0.7410.12
273_H461_T0.7400.12
155_K162_Q0.7400.12
538_L626_S0.7400.12
593_D596_S0.7380.12
150_Q173_L0.7370.12
228_L530_Q0.7360.12
490_D596_S0.7340.12
302_Q639_R0.7340.12
527_Y669_L0.7330.12
332_L343_L0.7330.12
156_N172_L0.7330.12
315_H585_G0.7330.12
303_R426_D0.7310.12
354_A374_D0.7290.12
199_F590_F0.7280.12
199_F315_H0.7280.12
291_A491_K0.7260.12
225_G273_H0.7250.12
159_I163_P0.7230.12
519_F524_N0.7220.12
469_A472_Q0.7220.12
129_L134_S0.7170.12
603_G613_D0.7170.12
107_I118_V0.7110.12
251_P466_E0.7110.12
227_D236_D0.7100.12
212_R444_W0.7080.12
343_L349_D0.7060.12
280_W504_A0.7060.12
101_P105_I0.7050.12
287_M329_F0.7040.12
473_L520_D0.7040.12
192_Y235_L0.7030.12
235_L284_D0.7030.12
235_L592_G0.7030.12
235_L594_E0.7030.12
416_G421_Y0.7030.12
158_Q164_A0.7030.12
396_D399_M0.7030.12
314_N458_R0.7020.12
191_V306_R0.7010.12
293_L309_F0.7010.12
539_A543_T0.7000.12
144_R154_V0.6960.12
376_W392_P0.6960.12
328_Q471_Q0.6950.12
126_G130_T0.6950.12
282_N459_V0.6950.12
273_H590_F0.6950.12
151_I163_P0.6940.12
153_I157_G0.6940.12
202_G661_R0.6930.12
254_Q501_T0.6930.12
329_F334_L0.6930.12
417_L422_K0.6930.12
105_I108_Q0.6920.12
527_Y571_E0.6910.12
230_G591_Y0.6910.12
315_H590_F0.6910.12
434_G628_A0.6900.12
196_T602_T0.6890.12
162_Q169_G0.6880.12
202_G234_K0.6880.12
398_T401_L0.6870.12
335_S339_V0.6870.12
225_G314_N0.6860.12
247_W457_F0.6860.12
315_H564_H0.6840.12
196_T461_T0.6820.12
187_H249_S0.6800.12
527_Y545_W0.6770.11
340_K345_E0.6770.11
251_P276_Y0.6770.11
413_T632_K0.6770.11
275_Y661_R0.6720.11
460_D661_R0.6720.11
230_G590_F0.6710.11
104_M123_K0.6710.11
185_D203_D0.6690.11
415_S419_V0.6690.11
191_V558_L0.6680.11
155_K174_E0.6670.11
270_Y560_Y0.6670.11
458_R591_Y0.6660.11
393_G533_K0.6650.11
236_D303_R0.6640.11
223_F448_W0.6630.11
427_T430_K0.6630.11
225_G315_H0.6620.11
108_Q115_A0.6610.11
206_N237_Y0.6610.11
402_A405_P0.6610.11
225_G230_G0.6570.11
325_Q334_L0.6570.11
230_G646_G0.6560.11
166_T172_L0.6560.11
429_A433_D0.6550.11
294_R556_N0.6540.11
314_N646_G0.6540.11
457_F498_F0.6540.11
506_G586_A0.6520.11
102_T493_L0.6520.11
295_T643_I0.6520.11
275_Y503_E0.6510.11
275_Y565_D0.6510.11
459_V462_A0.6510.11
460_D503_E0.6510.11
460_D565_D0.6510.11
236_D273_H0.6510.11
277_T656_G0.6510.11
199_F241_L0.6500.11
250_A276_Y0.6490.11
153_I159_I0.6490.11
185_D583_A0.6490.11
230_G461_T0.6490.11
469_A476_E0.6480.11
188_N644_G0.6480.11
511_Q527_Y0.6480.11
225_G271_A0.6480.11
365_I369_D0.6470.11
333_Y338_E0.6470.11
103_L110_A0.6460.11
105_I117_L0.6450.11
100_T103_L0.6440.11
187_H521_A0.6440.11
230_G310_D0.6440.11
230_G241_L0.6440.11
275_Y564_H0.6430.11
460_D564_H0.6430.11
202_G502_G0.6390.11
235_L453_G0.6390.11
149_Q156_N0.6380.11
332_L340_K0.6360.11
224_H614_M0.6360.11
157_G167_S0.6340.11
614_M617_Q0.6340.11
310_D314_N0.6320.11
401_L405_P0.6320.11
107_I111_A0.6290.11
197_D201_N0.6290.11
315_H502_G0.6290.11
252_F280_W0.6270.11
112_E117_L0.6260.11
437_P642_A0.6260.11
98_S102_T0.6250.11
227_D241_L0.6240.11
250_A576_A0.6240.11
447_Q451_D0.6240.11
372_G469_A0.6240.11
198_R458_R0.6230.11
602_T611_R0.6220.11
618_D623_S0.6210.11
197_D611_R0.6190.11
239_Q302_Q0.6180.11
287_M445_L0.6180.11
99_G104_M0.6170.11
246_L285_A0.6170.11
250_A324_M0.6150.11
373_W378_G0.6150.11
104_M107_I0.6140.11
251_P445_L0.6140.11
149_Q164_A0.6130.11
193_F254_Q0.6130.11
156_N161_L0.6130.11
141_A144_R0.6120.11
341_K346_R0.6120.11
121_C144_R0.6110.11
570_R623_S0.6110.11
106_S114_V0.6100.11
137_F154_V0.6090.11
227_D458_R0.6080.11
190_T387_G0.6080.11
103_L108_Q0.6070.10
411_S416_G0.6070.10
154_V165_A0.6060.10
152_A158_Q0.6060.10
310_D591_Y0.6060.10
580_L583_A0.6030.10
456_G470_W0.6020.10
105_I112_E0.6020.10
193_F249_S0.6010.10
244_N671_V0.6010.10
201_N303_R0.6000.10
520_D563_S0.6000.10
226_G235_L0.6000.10
155_K165_A0.5990.10
241_L591_Y0.5990.10
325_Q329_F0.5980.10
457_F464_H0.5980.10
156_N160_M0.5970.10
246_L496_K0.5960.10
277_T539_A0.5960.10
336_G342_S0.5960.10
314_N593_D0.5950.10
190_T248_I0.5930.10
287_M290_E0.5920.10
533_K571_E0.5920.10
270_Y563_S0.5910.10
348_S351_K0.5890.10
574_D634_S0.5880.10
197_D593_D0.5860.10
549_A552_L0.5850.10
198_R236_D0.5840.10
100_T109_N0.5830.10
278_Q311_V0.5830.10
309_F603_G0.5830.10
502_G661_R0.5820.10
273_H458_R0.5820.10
285_A530_Q0.5810.10
457_F461_T0.5800.10
318_Y562_S0.5790.10
194_V231_L0.5790.10
275_Y314_N0.5780.10
314_N460_D0.5780.10
269_H445_L0.5780.10
327_Y338_E0.5780.10
299_S491_K0.5770.10
288_G596_S0.5770.10
150_Q153_I0.5760.10
196_T311_V0.5760.10
387_G561_L0.5740.10
198_R502_G0.5730.10
226_G242_G0.5730.10
106_S368_S0.5720.10
181_S543_T0.5710.10
593_D611_R0.5710.10
198_R241_L0.5710.10
229_R633_I0.5680.10
356_Q361_F0.5660.10
376_W379_K0.5660.10
198_R585_G0.5650.10
230_G234_K0.5650.10
152_A174_E0.5630.10
100_T133_V0.5630.10
299_S412_T0.5620.10
298_D596_S0.5600.10
109_N116_S0.5590.10
299_S620_S0.5590.10
315_H461_T0.5580.10
199_F202_G0.5570.10
356_Q359_H0.5570.10
344_G348_S0.5560.10
273_H564_H0.5560.10
244_N561_L0.5560.10
308_L328_Q0.5550.10
367_F548_M0.5540.10
604_S611_R0.5540.10
241_L661_R0.5540.10
201_N293_L0.5540.10
529_E590_F0.5540.10
313_M590_F0.5530.10
537_C546_Q0.5520.10
235_L304_G0.5510.10
448_W611_R0.5510.10
193_F560_Y0.5510.10
198_R310_D0.5510.10
279_D315_H0.5500.10
187_H296_L0.5500.10
462_A522_M0.5500.10
308_L655_Q0.5490.10
391_N434_G0.5480.10
163_P168_N0.5470.10
99_G105_I0.5460.10
225_G276_Y0.5460.10
329_F343_L0.5450.10
393_G406_D0.5440.10
327_Y332_L0.5440.10
442_T638_A0.5440.10
561_L579_L0.5420.10
161_L635_Q0.5420.10
564_H585_G0.5410.10
393_G657_Y0.5410.10
276_Y604_S0.5400.10
205_S229_R0.5400.10
396_D401_L0.5400.10
472_Q570_R0.5400.10
652_L669_L0.5400.10
222_T320_T0.5390.10
462_A669_L0.5390.10
369_D385_D0.5380.10
285_A388_D0.5370.10
209_S212_R0.5370.10
249_S504_A0.5340.10
223_F317_G0.5330.10
273_H310_D0.5330.10
246_L605_D0.5330.10
523_I563_S0.5330.10
161_L665_D0.5320.10
225_G596_S0.5320.10
610_T616_W0.5310.10
119_R122_P0.5310.10
633_I642_A0.5300.10
461_T560_Y0.5300.10
250_A458_R0.5300.10
249_S274_G0.5280.09
228_L239_Q0.5270.09
276_Y445_L0.5270.09
117_L123_K0.5240.09
225_G470_W0.5210.09
312_V661_R0.5210.09
233_N295_T0.5200.09
192_Y242_G0.5200.09
242_G284_D0.5200.09
242_G592_G0.5200.09
242_G594_E0.5200.09
564_H646_G0.5200.09
536_D574_D0.5190.09
371_T628_A0.5180.09
228_L249_S0.5180.09
368_S610_T0.5170.09
230_G458_R0.5170.09
170_L297_V0.5170.09
165_A172_L0.5150.09
162_Q174_E0.5140.09
399_M406_D0.5140.09
417_L426_D0.5140.09
289_N511_Q0.5140.09
208_Q643_I0.5140.09
300_A641_P0.5130.09
228_L252_F0.5120.09
228_L277_T0.5120.09
563_S601_P0.5120.09
604_S616_W0.5120.09
596_S653_L0.5110.09
171_L174_E0.5100.09
101_P114_V0.5090.09
374_D633_I0.5070.09
491_K494_D0.5060.09
527_Y631_Q0.5060.09
272_Y525_F0.5060.09
490_D624_A0.5060.09
442_T472_Q0.5050.09
353_A414_A0.5050.09
237_Y453_G0.5040.09
249_S464_H0.5030.09
382_I415_S0.5030.09
193_F629_H0.5020.09
470_W520_D0.5020.09
491_K532_A0.5010.09
492_A574_D0.5010.09
237_Y241_L0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ea9C 2 0.7515 100 0.612 Contact Map
4aefA 1 0.8062 100 0.612 Contact Map
4aeeA 1 0.858 100 0.612 Contact Map
1j0hA 2 0.75 100 0.616 Contact Map
1wzlA 2 0.7515 100 0.618 Contact Map
1ji1A 1 0.7559 100 0.625 Contact Map
2wc7A 2 0.5799 100 0.627 Contact Map
1qhoA 1 0.6065 100 0.63 Contact Map
3bmvA 1 0.6183 100 0.636 Contact Map
1cygA 1 0.6139 100 0.636 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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