GREMLIN Database
METE - 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
UniProt: P25665 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10584
Length: 753 (743)
Sequences: 1672 (1014)
Seq/√Len: 37.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
469_I548_V6.5551.00
395_R583_D5.0401.00
74_S167_W4.8411.00
331_D351_Q4.8311.00
466_K470_V4.7021.00
299_A304_K4.6911.00
130_F171_G4.6181.00
568_V573_I4.2701.00
453_D456_N3.9031.00
61_V157_V3.8611.00
708_L722_V3.8381.00
70_V162_L3.8151.00
705_E749_N3.7611.00
598_I629_A3.7391.00
26_Y94_D3.6191.00
501_F558_I3.6061.00
458_R535_E3.5561.00
32_T35_E3.4831.00
420_R594_G3.4341.00
408_N634_D3.2971.00
497_H532_I3.2591.00
141_T145_D3.1831.00
302_T375_S3.1331.00
142_Q146_E3.0691.00
734_P738_A3.0681.00
147_V203_I3.0251.00
148_D201_R3.0161.00
446_D451_N2.9781.00
447_F454_A2.9691.00
44_R149_E2.9651.00
7_T321_S2.9191.00
65_A72_T2.8381.00
247_V254_I2.7961.00
147_V156_K2.7801.00
195_L206_V2.7281.00
40_G66_W2.6861.00
162_L166_T2.6551.00
342_V502_V2.6441.00
466_K543_L2.6241.00
185_N227_P2.5931.00
421_F595_I2.5651.00
337_R505_Q2.5601.00
69_H162_L2.4361.00
611_R614_W2.3581.00
291_I299_A2.3491.00
697_N703_W2.3151.00
476_G748_Q2.3011.00
454_A458_R2.2640.99
574_A624_A2.2580.99
648_N676_S2.2490.99
442_T446_D2.2480.99
43_L47_H2.2480.99
204_E237_K2.1920.99
410_Y414_A2.1850.99
156_K204_E2.1850.99
526_I577_I2.1580.99
471_E737_R2.1580.99
77_L190_V2.1540.99
144_L194_V2.1450.99
77_L187_I2.1380.99
389_N499_D2.1260.99
418_R685_E2.1240.99
33_R94_D2.1120.99
615_D619_Q2.0980.99
23_Q514_S2.0900.99
701_V745_Q2.0620.99
701_V742_N2.0570.99
62_G142_Q2.0550.99
345_W381_R2.0500.99
10_F350_L2.0330.99
537_A593_I2.0330.99
389_N527_S2.0180.99
321_S356_L2.0170.99
113_A126_M2.0150.99
99_I113_A2.0020.99
495_G503_F1.9980.99
26_Y33_R1.9970.99
147_V157_V1.9890.99
601_P657_L1.9890.99
464_H467_Q1.9830.98
319_V356_L1.9720.98
290_L308_I1.9720.98
144_L201_R1.9640.98
388_H393_E1.9600.98
400_T403_D1.9580.98
161_L194_V1.9520.98
443_L452_L1.9400.98
216_E610_R1.9360.98
443_L461_I1.9320.98
114_E172_K1.9310.98
120_N268_H1.9000.98
58_L158_K1.8890.98
581_L601_P1.8860.98
476_G546_K1.8660.98
160_V209_D1.8610.98
712_A717_A1.8610.98
300_D303_E1.8460.98
50_Q350_L1.8340.97
218_P221_W1.8320.97
737_R741_A1.8230.97
414_A685_E1.8220.97
619_Q623_E1.8210.97
479_V595_I1.8150.97
169_W221_W1.7850.97
10_F50_Q1.7720.97
459_T463_E1.7710.97
614_W649_D1.7640.97
732_G736_T1.7570.97
564_P573_I1.7570.97
379_Q383_H1.7490.97
79_N167_W1.7390.96
74_S113_A1.7360.96
37_L66_W1.7220.96
205_W239_L1.7190.96
421_F594_G1.7170.96
492_E518_K1.7110.96
339_D386_R1.7100.96
288_A311_I1.7080.96
412_V634_D1.6950.96
462_A535_E1.6920.96
534_V591_A1.6900.96
266_L288_A1.6870.96
77_L194_V1.6780.96
426_W750_L1.6770.96
33_R37_L1.6740.96
471_E475_L1.6730.96
298_R374_W1.6700.96
49_D53_Q1.6570.95
458_R462_A1.6500.95
45_A153_L1.6400.95
333_S350_L1.6370.95
7_T60_P1.6320.95
655_A684_N1.6320.95
206_V236_V1.6320.95
575_K623_E1.6310.95
589_E632_A1.6290.95
179_D182_S1.6250.95
445_L449_K1.6220.95
501_F526_I1.6110.95
560_C601_P1.6110.95
241_T263_H1.6110.95
84_H110_A1.5920.94
192_Q232_L1.5900.94
305_Y359_L1.5890.94
281_P284_W1.5860.94
334_V506_N1.5840.94
539_Y543_L1.5840.94
57_D360_R1.5830.94
716_P719_R1.5800.94
470_V474_R1.5660.94
732_G738_A1.5640.94
80_V99_I1.5540.93
144_L197_E1.5510.93
443_L460_G1.5210.93
582_R631_V1.5170.93
5_N356_L1.5140.93
586_A631_V1.5020.92
292_N566_E1.4990.92
468_A485_A1.4970.92
38_A42_E1.4950.92
5_N319_V1.4870.92
440_I485_A1.4830.92
374_W378_I1.4770.92
698_V732_G1.4720.91
140_W144_L1.4650.91
98_R103_R1.4590.91
240_L254_I1.4590.91
358_L371_L1.4570.91
21_K25_S1.4550.91
269_G272_D1.4480.91
312_V317_L1.4450.91
172_K672_E1.4400.90
186_D189_P1.4340.90
309_K367_D1.4340.90
701_V749_N1.4270.90
603_L645_C1.4210.90
671_M707_L1.4180.90
174_K670_D1.4170.90
715_I720_L1.4150.90
141_T197_E1.4070.89
374_W377_P1.4050.89
214_V242_T1.4030.89
166_T212_A1.4010.89
222_L250_N1.3980.89
104_A109_P1.3970.89
564_P569_S1.3940.89
412_V415_E1.3930.89
332_L343_K1.3870.89
212_A215_L1.3740.88
528_R587_D1.3730.88
585_V598_I1.3700.88
586_A632_A1.3690.88
399_I403_D1.3690.88
574_A620_W1.3610.88
456_N459_T1.3560.88
539_Y542_S1.3460.87
15_L46_R1.3460.87
65_A96_L1.3450.87
73_T77_L1.3450.87
226_K230_D1.3430.87
466_K539_Y1.3420.87
42_E46_R1.3420.87
390_P394_K1.3410.87
41_R152_A1.3340.87
212_A225_Y1.3320.87
404_S623_E1.3280.87
80_V139_T1.3280.87
404_S627_I1.3260.86
138_L190_V1.3210.86
245_E610_R1.3190.86
192_Q231_A1.3180.86
73_T76_L1.3160.86
7_T353_C1.3140.86
49_D52_K1.3110.86
601_P628_N1.3060.86
16_R506_N1.3030.85
277_H311_I1.3000.85
56_I353_C1.2980.85
396_L399_I1.2850.85
308_I319_V1.2810.84
258_P284_W1.2780.84
568_V572_T1.2770.84
222_L253_T1.2760.84
184_L228_A1.2730.84
189_P231_A1.2730.84
59_L155_H1.2710.84
467_Q471_E1.2700.84
469_I543_L1.2690.84
331_D334_V1.2640.84
399_I404_S1.2640.84
266_L272_D1.2630.84
338_L504_T1.2600.83
130_F183_L1.2580.83
165_V217_L1.2580.83
226_K256_A1.2560.83
76_L143_L1.2550.83
83_R129_E1.2510.83
250_N254_I1.2510.83
261_G285_L1.2500.83
308_I363_L1.2490.83
558_I577_I1.2490.83
564_P568_V1.2490.83
570_R606_G1.2480.83
499_D527_S1.2430.83
109_P697_N1.2420.83
575_K627_I1.2390.82
277_H310_D1.2360.82
45_A49_D1.2360.82
474_R741_A1.2340.82
280_L284_W1.2340.82
448_K492_E1.2290.82
183_L186_D1.2240.82
465_I485_A1.2230.82
135_Q186_D1.2220.81
452_L456_N1.2170.81
404_S575_K1.2160.81
6_H158_K1.2150.81
556_V574_A1.2130.81
60_P160_V1.2090.81
216_E612_S1.2070.81
239_L261_G1.2060.81
62_G157_V1.1990.80
185_N231_A1.1970.80
16_R334_V1.1950.80
79_N136_F1.1950.80
148_D151_L1.1940.80
745_Q749_N1.1920.80
474_R737_R1.1920.80
426_W747_A1.1910.80
41_R149_E1.1860.79
78_G85_Q1.1860.79
616_A619_Q1.1830.79
76_L144_L1.1820.79
22_A39_V1.1770.79
589_E636_T1.1750.79
213_L225_Y1.1750.79
233_Q260_Q1.1740.79
254_I262_L1.1730.79
5_N360_R1.1730.79
7_T56_I1.1730.79
25_S31_S1.1670.78
91_V95_T1.1660.78
394_K398_A1.1600.78
711_A720_L1.1590.78
5_N56_I1.1540.78
344_S377_P1.1490.77
702_E706_A1.1480.77
285_L318_W1.1450.77
308_I359_L1.1420.77
405_Q626_R1.1410.77
305_Y362_A1.1400.77
60_P159_P1.1400.77
147_V201_R1.1400.77
707_L711_A1.1390.77
245_E613_D1.1380.77
475_L741_A1.1330.76
598_I628_N1.1300.76
10_F349_A1.1230.76
296_V521_I1.1230.76
181_L224_A1.1220.76
72_T96_L1.1210.75
70_V166_T1.1200.75
623_E627_I1.1180.75
132_K176_E1.1180.75
291_I304_K1.1170.75
701_V705_E1.1160.75
415_E419_A1.1150.75
414_A719_R1.1090.75
462_A539_Y1.1070.75
357_A361_D1.1060.74
116_T672_E1.1020.74
698_V734_P1.1000.74
531_P587_D1.1000.74
173_V180_R1.0990.74
78_G137_K1.0950.74
459_T462_A1.0940.74
365_S369_A1.0920.74
745_Q748_Q1.0880.73
463_E466_K1.0870.73
448_K518_K1.0840.73
301_L358_L1.0790.73
704_I747_A1.0760.72
362_A366_G1.0750.72
409_V412_V1.0740.72
79_N130_F1.0740.72
601_P645_C1.0730.72
244_F323_C1.0730.72
410_Y685_E1.0730.72
48_W153_L1.0730.72
276_L311_I1.0700.72
195_L208_I1.0690.72
708_L750_L1.0680.72
646_E672_E1.0650.72
98_R697_N1.0640.72
263_H287_S1.0600.71
61_V147_V1.0550.71
547_P594_G1.0520.71
585_V628_N1.0500.71
698_V738_A1.0500.71
461_I465_I1.0500.71
98_R104_A1.0490.70
291_I356_L1.0490.70
426_W717_A1.0470.70
33_R91_V1.0440.70
671_M711_A1.0390.70
356_L360_R1.0390.70
31_S35_E1.0370.70
290_L304_K1.0370.70
652_D656_A1.0360.70
199_A235_Q1.0340.69
62_G143_L1.0320.69
301_L362_A1.0320.69
614_W650_I1.0310.69
341_E386_R1.0310.69
251_L280_L1.0300.69
113_A167_W1.0300.69
158_K318_W1.0280.69
151_L156_K1.0280.69
420_R635_D1.0220.68
41_R44_R1.0210.68
34_E38_A1.0190.68
75_L96_L1.0180.68
301_L359_L1.0140.68
165_V228_A1.0090.67
199_A236_V1.0060.67
131_V134_Q1.0010.67
655_A683_P1.0000.67
45_A149_E0.9990.67
447_F452_L0.9970.67
366_G369_A0.9970.67
501_F577_I0.9940.66
477_L546_K0.9900.66
543_L547_P0.9890.66
271_D274_A0.9880.66
559_L574_A0.9870.66
698_V736_T0.9830.65
366_G370_A0.9830.65
78_G139_T0.9800.65
244_F324_S0.9780.65
22_A36_L0.9760.65
579_L627_I0.9740.65
440_I460_G0.9740.65
62_G146_E0.9740.65
217_L221_W0.9710.64
188_L228_A0.9650.64
705_E709_K0.9620.64
143_L147_V0.9590.63
28_A732_G0.9590.63
268_H292_N0.9570.63
169_W212_A0.9560.63
136_F187_I0.9520.63
33_R93_I0.9510.63
497_H530_A0.9500.63
560_C570_R0.9460.62
60_P155_H0.9450.62
426_W712_A0.9440.62
251_L276_L0.9440.62
85_Q91_V0.9430.62
377_P380_A0.9430.62
649_D739_A0.9430.62
140_W190_V0.9420.62
169_W218_P0.9400.62
190_V193_Q0.9380.62
70_V167_W0.9370.62
72_T142_Q0.9360.62
560_C606_G0.9350.61
440_I461_I0.9340.61
747_A751_R0.9340.61
103_R697_N0.9330.61
12_R69_H0.9310.61
361_D365_S0.9270.61
535_E538_K0.9260.61
12_R510_Q0.9260.61
39_V42_E0.9250.61
251_L255_T0.9240.61
525_D576_Q0.9230.60
213_L240_L0.9200.60
103_R109_P0.9160.60
341_E384_S0.9130.60
517_V520_P0.9120.60
334_V351_Q0.9110.59
493_Y536_W0.9080.59
185_N189_P0.9080.59
499_D529_P0.9040.59
166_T169_W0.9040.59
132_K178_F0.9010.59
247_V264_V0.9010.59
74_S171_G0.9000.58
88_D95_T0.8990.58
60_P157_V0.8990.58
536_W674_L0.8980.58
205_W261_G0.8980.58
203_I206_V0.8970.58
463_E467_Q0.8960.58
384_S388_H0.8920.58
242_T247_V0.8910.58
291_I359_L0.8890.58
138_L194_V0.8880.57
416_A419_A0.8880.57
147_V198_L0.8860.57
407_A634_D0.8860.57
381_R566_E0.8850.57
114_E672_E0.8850.57
84_H99_I0.8830.57
165_V224_A0.8810.57
22_A31_S0.8810.57
614_W667_S0.8780.57
354_H357_A0.8780.57
10_F47_H0.8770.57
193_Q197_E0.8740.56
74_S79_N0.8710.56
691_Y739_A0.8710.56
31_S39_V0.8690.56
571_E575_K0.8690.56
52_K155_H0.8680.56
178_F182_S0.8680.56
264_V288_A0.8640.55
537_A581_L0.8620.55
594_G635_D0.8610.55
341_E380_A0.8610.55
304_K319_V0.8580.55
392_V525_D0.8570.55
530_A535_E0.8540.54
403_D627_I0.8530.54
13_V516_C0.8530.54
607_L618_L0.8530.54
589_E633_K0.8520.54
56_I59_L0.8520.54
264_V279_R0.8470.54
471_E474_R0.8470.54
655_A680_F0.8460.54
36_L40_G0.8460.54
287_S318_W0.8460.54
537_A548_V0.8460.54
169_W215_L0.8450.54
144_L148_D0.8420.53
205_W237_K0.8420.53
70_V73_T0.8410.53
197_E201_R0.8410.53
158_K492_E0.8400.53
56_I60_P0.8390.53
239_L263_H0.8360.53
628_N657_L0.8350.53
614_W685_E0.8350.53
65_A142_Q0.8340.53
528_R583_D0.8340.53
8_L241_T0.8330.53
353_C560_C0.8280.52
91_V139_T0.8280.52
358_L362_A0.8280.52
704_I743_M0.8270.52
251_L279_R0.8250.52
61_V156_K0.8250.52
77_L167_W0.8240.52
130_F167_W0.8220.52
76_L140_W0.8210.52
159_P203_I0.8200.52
504_T521_I0.8180.51
465_I537_A0.8170.51
165_V212_A0.8140.51
473_E480_L0.8140.51
523_I564_P0.8130.51
688_P720_L0.8130.51
82_A131_V0.8130.51
116_T711_A0.8130.51
414_A418_R0.8130.51
287_S320_A0.8110.51
164_P184_L0.8110.51
84_H98_R0.8100.51
309_K313_G0.8090.51
467_Q733_W0.8090.51
80_V95_T0.8080.50
77_L138_L0.8080.50
158_K663_T0.8060.50
586_A589_E0.8040.50
558_I581_L0.8030.50
410_Y719_R0.8020.50
140_W145_D0.8020.50
169_W217_L0.7990.50
506_N516_C0.7980.50
76_L138_L0.7980.50
345_W384_S0.7980.50
298_R377_P0.7970.49
571_E616_A0.7960.49
95_T139_T0.7960.49
399_I627_I0.7940.49
139_T144_L0.7940.49
575_K624_A0.7940.49
358_L370_A0.7930.49
673_L686_I0.7930.49
15_L330_I0.7910.49
371_L374_W0.7900.49
391_A527_S0.7900.49
438_T732_G0.7900.49
408_N412_V0.7900.49
86_N91_V0.7870.49
10_F152_A0.7860.48
372_A376_A0.7820.48
401_A405_Q0.7800.48
161_L208_I0.7800.48
19_L40_G0.7760.48
7_T320_A0.7760.48
116_T172_K0.7730.47
80_V212_A0.7710.47
40_G97_F0.7690.47
346_F569_S0.7670.47
225_Y271_D0.7670.47
742_N745_Q0.7650.47
171_G174_K0.7650.47
301_L374_W0.7640.47
663_T712_A0.7640.47
522_V577_I0.7640.47
233_Q258_P0.7620.46
702_E749_N0.7620.46
393_E572_T0.7620.46
298_R332_L0.7620.46
247_V250_N0.7600.46
147_V151_L0.7570.46
585_V632_A0.7560.46
645_C664_I0.7550.46
744_V747_A0.7530.46
76_L142_Q0.7520.46
305_Y366_G0.7510.45
138_L193_Q0.7510.45
360_R364_N0.7510.45
217_L222_L0.7500.45
402_Q405_Q0.7490.45
344_S380_A0.7480.45
103_R110_A0.7480.45
603_L657_L0.7470.45
338_L502_V0.7470.45
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263_H288_A0.7430.45
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263_H320_A0.7420.45
222_L254_I0.7410.45
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82_A133_G0.7400.44
346_F521_I0.7390.44
309_K312_V0.7380.44
468_A471_E0.7380.44
39_V43_L0.7380.44
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365_S368_T0.7360.44
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262_L286_L0.7110.42
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305_Y363_L0.7090.42
213_L254_I0.7090.42
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379_Q382_R0.7070.42
663_T670_D0.7060.42
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209_D326_L0.7020.41
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666_T671_M0.7000.41
423_L427_P0.7000.41
336_T505_Q0.7000.41
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277_H288_A0.6940.40
346_F523_I0.6930.40
339_D344_S0.6930.40
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6_H318_W0.6920.40
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140_W194_V0.6900.40
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173_V178_F0.6890.40
60_P326_L0.6870.40
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188_L192_Q0.6860.40
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242_T248_T0.6820.39
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586_A628_N0.6800.39
244_F517_V0.6800.39
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321_S353_C0.6780.39
144_L198_L0.6760.39
544_T548_V0.6760.39
345_W386_R0.6760.39
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148_D197_E0.6750.39
188_L331_D0.6750.39
581_L657_L0.6750.39
495_G551_M0.6740.39
715_I719_R0.6720.39
302_T374_W0.6720.39
60_P321_S0.6720.39
446_D449_K0.6710.39
61_V158_K0.6710.39
611_R615_D0.6700.38
345_W387_V0.6690.38
140_W197_E0.6690.38
440_I465_I0.6690.38
172_K669_S0.6680.38
537_A601_P0.6670.38
646_E649_D0.6670.38
296_V503_F0.6670.38
690_V704_I0.6660.38
461_I485_A0.6660.38
426_W708_L0.6650.38
666_T673_L0.6640.38
94_D336_T0.6630.38
152_A223_D0.6620.38
276_L280_L0.6620.38
198_L201_R0.6620.38
377_P381_R0.6610.38
110_A113_A0.6610.38
243_Y323_C0.6600.38
678_E714_R0.6600.38
663_T674_L0.6590.38
261_G318_W0.6570.37
13_V645_C0.6560.37
161_L189_P0.6550.37
169_W663_T0.6550.37
10_F353_C0.6540.37
79_N187_I0.6540.37
732_G735_E0.6540.37
25_S28_A0.6530.37
583_D587_D0.6520.37
291_I614_W0.6520.37
346_F564_P0.6520.37
230_D283_D0.6510.37
348_F521_I0.6510.37
163_G210_E0.6500.37
371_L377_P0.6500.37
168_L183_L0.6490.37
118_W244_F0.6490.37
278_K314_K0.6480.37
114_E669_S0.6470.37
410_Y683_P0.6460.36
188_L351_Q0.6460.36
246_G610_R0.6450.36
214_V245_E0.6430.36
556_V620_W0.6420.36
208_I292_N0.6410.36
255_T279_R0.6410.36
223_D226_K0.6410.36
495_G522_V0.6400.36
235_Q260_Q0.6400.36
734_P737_R0.6400.36
41_R45_A0.6390.36
138_L197_E0.6380.36
414_A718_E0.6380.36
37_L142_Q0.6380.36
96_L100_G0.6370.36
73_T194_V0.6370.36
116_T127_V0.6370.36
250_N610_R0.6360.36
15_L334_V0.6340.35
38_A590_A0.6340.35
4_L57_D0.6330.35
569_S573_I0.6320.35
425_A718_E0.6320.35
374_W381_R0.6320.35
375_S379_Q0.6310.35
604_R618_L0.6310.35
708_L746_A0.6300.35
140_W146_E0.6300.35
83_R158_K0.6300.35
62_G657_L0.6290.35
99_I126_M0.6290.35
469_I537_A0.6280.35
156_K203_I0.6280.35
606_G677_F0.6280.35
196_A199_A0.6270.35
506_N521_I0.6270.35
531_P534_V0.6270.35
33_R92_D0.6260.35
133_G382_R0.6260.35
706_A713_K0.6260.35
392_V396_L0.6260.35
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241_T267_V0.6200.34
224_A228_A0.6200.34
326_L517_V0.6170.34
15_L47_H0.6150.34
92_D95_T0.6150.34
664_I677_F0.6140.34
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398_A401_A0.6120.34
306_A367_D0.6110.34
88_D91_V0.6110.34
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418_R718_E0.6110.34
151_L157_V0.6090.33
277_H314_K0.6090.33
62_G155_H0.6090.33
256_A734_P0.6070.33
69_H207_Q0.6070.33
51_Q353_C0.6060.33
51_Q321_S0.6050.33
181_L221_W0.6050.33
130_F134_Q0.6040.33
208_I229_Y0.6040.33
136_F181_L0.6020.33
272_D277_H0.6020.33
702_E705_E0.6000.33
62_G65_A0.6000.33
162_L241_T0.6000.33
447_F716_P0.5990.33
675_E679_E0.5990.33
586_A590_A0.5980.33
178_F183_L0.5980.33
522_V573_I0.5970.33
376_A379_Q0.5960.32
61_V159_P0.5950.32
376_A380_A0.5950.32
109_P703_W0.5950.32
4_L58_L0.5940.32
314_K317_L0.5940.32
503_F657_L0.5930.32
194_V468_A0.5930.32
84_H95_T0.5930.32
366_G722_V0.5930.32
396_L627_I0.5930.32
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537_A595_I0.5910.32
390_P409_V0.5900.32
23_Q663_T0.5900.32
663_T722_V0.5890.32
120_N294_R0.5890.32
241_T320_A0.5890.32
272_D311_I0.5880.32
674_L688_P0.5870.32
677_F682_Y0.5870.32
706_A718_E0.5860.32
76_L197_E0.5860.32
585_V629_A0.5840.32
143_L157_V0.5840.32
225_Y657_L0.5840.32
239_L287_S0.5840.32
673_L682_Y0.5840.32
179_D220_A0.5840.32
47_H518_K0.5840.32
362_A371_L0.5820.31
323_C532_I0.5820.31
89_G95_T0.5820.31
507_G581_L0.5820.31
504_T581_L0.5820.31
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53_Q548_V0.5800.31
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6_H58_L0.5790.31
40_G62_G0.5790.31
495_G520_P0.5790.31
290_L302_T0.5790.31
66_W96_L0.5790.31
293_G323_C0.5780.31
79_N99_I0.5780.31
651_M678_E0.5770.31
32_T38_A0.5760.31
419_A422_K0.5760.31
670_D703_W0.5750.31
477_L560_C0.5750.31
678_E713_K0.5750.31
76_L194_V0.5750.31
596_I636_T0.5750.31
345_W566_E0.5740.31
292_N384_S0.5740.31
456_N460_G0.5730.31
342_V523_I0.5730.31
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331_D350_L0.5720.31
113_A697_N0.5720.31
440_I736_T0.5710.31
384_S566_E0.5710.31
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219_Q223_D0.5700.30
141_T144_L0.5690.30
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220_A223_D0.5590.30
348_F504_T0.5590.30
667_S710_K0.5580.30
111_A697_N0.5580.30
49_D155_H0.5570.30
604_R607_L0.5570.30
279_R283_D0.5570.30
629_A632_A0.5550.29
420_R547_P0.5550.29
461_I715_I0.5540.29
28_A449_K0.5530.29
649_D663_T0.5530.29
157_V203_I0.5530.29
454_A578_A0.5520.29
99_I532_I0.5520.29
76_L146_E0.5520.29
454_A535_E0.5510.29
200_K405_Q0.5510.29
75_L99_I0.5510.29
333_S343_K0.5510.29
56_I77_L0.5510.29
165_V290_L0.5500.29
218_P278_K0.5500.29
241_T321_S0.5500.29
77_L140_W0.5490.29
570_R577_I0.5490.29
304_K307_Q0.5490.29
589_E626_R0.5490.29
248_T275_E0.5490.29
672_E711_A0.5490.29
663_T715_I0.5470.29
121_T323_C0.5460.29
119_F166_T0.5460.29
6_H320_A0.5460.29
705_E746_A0.5460.29
247_V251_L0.5460.29
700_S742_N0.5460.29
255_T283_D0.5460.29
73_T577_I0.5460.29
86_N89_G0.5450.29
560_C573_I0.5450.29
126_M445_L0.5450.29
263_H733_W0.5450.29
652_D679_E0.5440.29
548_V752_R0.5440.29
373_E376_A0.5440.29
452_L461_I0.5440.29
392_V395_R0.5430.28
452_L507_G0.5430.28
104_A110_A0.5430.28
138_L144_L0.5420.28
7_T708_L0.5420.28
292_N295_N0.5420.28
167_W171_G0.5410.28
219_Q222_L0.5410.28
709_K750_L0.5410.28
8_L160_V0.5410.28
254_I284_W0.5410.28
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36_L93_I0.5400.28
263_H272_D0.5400.28
25_S43_L0.5390.28
501_F504_T0.5390.28
98_R113_A0.5390.28
223_D702_E0.5390.28
302_T347_A0.5390.28
601_P675_E0.5380.28
688_P707_L0.5380.28
405_Q630_A0.5380.28
162_L208_I0.5370.28
69_H573_I0.5370.28
180_R184_L0.5370.28
82_A722_V0.5360.28
403_D574_A0.5360.28
333_S351_Q0.5350.28
143_L167_W0.5340.28
632_A638_I0.5340.28
347_A627_I0.5340.28
362_A369_A0.5330.28
93_I150_A0.5330.28
673_L715_I0.5330.28
468_A537_A0.5330.28
226_K713_K0.5330.28
371_L375_S0.5320.28
165_V221_W0.5320.28
693_I697_N0.5320.28
438_T442_T0.5320.28
54_A354_H0.5320.28
650_I662_I0.5320.28
247_V284_W0.5320.28
144_L147_V0.5320.28
136_F183_L0.5310.28
248_T610_R0.5300.28
226_K278_K0.5300.28
34_E309_K0.5300.28
13_V330_I0.5300.28
98_R110_A0.5300.28
502_V522_V0.5300.28
19_L528_R0.5290.27
225_Y242_T0.5290.27
173_V177_Q0.5280.27
286_L341_E0.5280.27
230_D233_Q0.5280.27
8_L320_A0.5280.27
73_T712_A0.5270.27
51_Q158_K0.5270.27
675_E714_R0.5270.27
412_V416_A0.5260.27
231_A234_G0.5260.27
136_F189_P0.5260.27
405_Q623_E0.5260.27
214_V246_G0.5250.27
306_A394_K0.5250.27
165_V218_P0.5250.27
232_L238_L0.5250.27
365_S370_A0.5250.27
8_L209_D0.5250.27
112_A495_G0.5240.27
73_T162_L0.5240.27
242_T246_G0.5240.27
92_D140_W0.5240.27
537_A544_T0.5240.27
319_V477_L0.5240.27
29_G745_Q0.5230.27
419_A438_T0.5230.27
309_K366_G0.5220.27
559_L620_W0.5220.27
47_H63_D0.5220.27
319_V360_R0.5220.27
33_R249_P0.5220.27
287_S733_W0.5210.27
529_P532_I0.5200.27
47_H51_Q0.5200.27
140_W143_L0.5200.27
247_V276_L0.5200.27
37_L93_I0.5190.27
649_D666_T0.5190.27
674_L710_K0.5190.27
626_R630_A0.5190.27
526_I538_K0.5190.27
247_V255_T0.5190.27
604_R609_L0.5180.27
499_D521_I0.5180.27
48_W146_E0.5170.27
238_L241_T0.5170.27
669_S672_E0.5170.27
492_E662_I0.5160.27
65_A245_E0.5160.27
384_S393_E0.5160.27
539_Y556_V0.5160.27
87_K98_R0.5160.27
394_K530_A0.5150.27
747_A750_L0.5150.27
332_L347_A0.5150.27
45_A48_W0.5140.26
598_I680_F0.5140.26
62_G520_P0.5140.26
80_V256_A0.5130.26
407_A598_I0.5130.26
471_E598_I0.5130.26
40_G144_L0.5130.26
84_H507_G0.5130.26
381_R387_V0.5120.26
623_E656_A0.5120.26
19_L65_A0.5120.26
350_L736_T0.5120.26
651_M676_S0.5120.26
75_L95_T0.5120.26
43_L203_I0.5120.26
283_D314_K0.5110.26
160_V207_Q0.5110.26
538_K591_A0.5100.26
96_L571_E0.5100.26
361_D470_V0.5100.26
384_S524_G0.5100.26
221_W318_W0.5100.26
151_L203_I0.5100.26
379_Q708_L0.5090.26
137_K193_Q0.5090.26
363_L620_W0.5090.26
495_G560_C0.5090.26
526_I703_W0.5090.26
634_D655_A0.5090.26
558_I573_I0.5090.26
471_E485_A0.5080.26
525_D565_R0.5080.26
443_L464_H0.5080.26
332_L506_N0.5070.26
447_F461_I0.5070.26
495_G537_A0.5070.26
460_G464_H0.5070.26
440_I686_I0.5070.26
581_L593_I0.5060.26
134_Q186_D0.5060.26
75_L92_D0.5050.26
239_L323_C0.5050.26
33_R66_W0.5050.26
350_L354_H0.5050.26
326_L510_Q0.5050.26
66_W72_T0.5050.26
438_T477_L0.5040.26
655_A671_M0.5040.26
176_E182_S0.5040.26
197_E526_I0.5040.26
7_T10_F0.5040.26
643_C726_C0.5030.26
35_E38_A0.5030.26
181_L184_L0.5030.26
570_R574_A0.5030.26
318_W492_E0.5020.26
558_I562_S0.5020.26
160_V326_L0.5020.26
87_K521_I0.5020.26
642_M677_F0.5010.26
648_N673_L0.5000.26
454_A465_I0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1t7lA 1 0.9655 100 0.322 Contact Map
4l6hA 1 0.9854 100 0.324 Contact Map
1u1jA 1 0.9734 100 0.334 Contact Map
2nq5A 1 0.927 100 0.356 Contact Map
3rpdA 1 0.4236 100 0.753 Contact Map
1ypxA 1 0.3918 100 0.754 Contact Map
2infA 2 0.4117 99.9 0.937 Contact Map
2ejaA 2 0.405 99.9 0.937 Contact Map
1j93A 2 0.413 99.9 0.938 Contact Map
4exqA 2 0.413 99.9 0.942 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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