ALDA - ECOLI - GREMLIN Contacts

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ALDA - Lactaldehyde dehydrogenase

UniProt:	P25553	Sequences: MSVPVQHPMYIDGQFVTWRGDAWIDVVNPATEAVISRIPDGQAEDARKAIDAAERAQPEWEALPAIERASWLRKISAGIRERASEISALIVEEGGKIQQLAEVEVAFTADYIDYMAEWARRYEGEIIQSDRPGENILLFKRALGVTTGILPWNFPFFLIARKMAPALLTGNTIVIKPSEFTPNNAIAFAKIVDEIGLPRGVFNLVLGRGETVGQELAGNPKVAMVSMTGSVSAGEKIMATAAKNITKVCLELGGKAPAIVMDDADLELAVKAIVDSRVINSGQVCNCAERVYVQKGIYDQFVNRLGEAMQAVQFGNPAERNDIAMGPLINAAALERVEQKVARAVEEGARVAFGGKAVEGKGYYYPPTLLLDVRQEMSIMHEETFGPVLPVVAFDTLEDAISMANDSDYGLTSSIYTQNLNVAMKAIKGLKFGETYINRENFEAMQGFHAGWRKSGIGGADGKHGLHEYLQTQVVYLQS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10035
Length:	479 (453)
Sequences:	36456 (21944)
Seq/√Len:	1031.0

ECOLI - ALDA GABD PUUC BETB ABDH FEAB ALDB ASTD SAD EUTE PUTA PAAZ PROA ADHE
BACSU - ALDH1 ALDH4 ROCA ROCA2 ALDH5 ALDY IOLA BETB GABD ALDH3 ALDH2 PROA
HALSA - Q9HQZ2 Q9HMJ6 Q9HRB5 Q9HR91
SULSO - Q97YT9 KGSDH GAPN Q97XS9 Q97XA5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
295_K	395_D	4.994	1.00
239_A	243_K	3.993	1.00
295_K	393_A	3.153	1.00
267_E	304_R	3.090	1.00
298_Y	393_A	2.951	1.00
25_D	37_R	2.842	1.00
356_K	366_P	2.784	1.00
54_E	221_K	2.761	1.00
262_D	294_Q	2.725	1.00
374_R	377_M	2.666	1.00
331_A	335_E	2.633	1.00
271_K	308_A	2.582	1.00
343_R	378_S	2.581	1.00
187_A	190_K	2.540	1.00
342_A	346_E	2.498	1.00
302_V	391_V	2.494	1.00
262_D	296_G	2.465	1.00
82_R	85_E	2.403	1.00
80_R	113_D	2.356	1.00
25_D	34_V	2.351	1.00
417_T	423_A	2.347	1.00
193_D	199_R	2.230	1.00
42_Q	45_D	2.207	1.00
54_E	223_A	2.199	1.00
341_V	365_Y	2.198	1.00
319_E	322_D	2.186	1.00
83_A	106_A	2.159	1.00
338_E	342_A	2.158	1.00
75_I	192_V	2.119	1.00
78_G	194_E	2.113	1.00
408_D	454_K	2.065	1.00
397_L	422_V	2.062	1.00
343_R	347_E	2.019	1.00
218_G	240_T	2.016	1.00
214_Q	218_G	2.011	1.00
180_F	330_N	1.997	1.00
350_R	372_D	1.978	1.00
141_R	473_Q	1.975	1.00
338_E	357_A	1.968	1.00
306_G	310_Q	1.929	1.00
258_A	273_I	1.921	1.00
425_K	429_G	1.920	1.00
85_E	187_A	1.916	1.00
328_L	337_V	1.909	1.00
300_Q	304_R	1.908	1.00
338_E	365_Y	1.907	1.00
140_K	467_H	1.896	1.00
352_A	371_L	1.849	1.00
71_W	197_L	1.848	1.00
47_R	215_E	1.846	1.00
236_K	239_A	1.836	1.00
263_D	422_V	1.823	1.00
235_E	454_K	1.810	1.00
51_D	221_K	1.807	1.00
345_V	351_V	1.786	1.00
78_G	81_E	1.781	1.00
292_Y	403_M	1.768	1.00
84_S	102_E	1.767	1.00
82_R	194_E	1.763	1.00
380_M	392_V	1.735	1.00
431_K	453_R	1.711	1.00
78_G	195_I	1.710	1.00
397_L	425_K	1.703	1.00
47_R	51_D	1.697	1.00
140_K	470_L	1.688	1.00
34_V	37_R	1.686	1.00
375_Q	403_M	1.648	1.00
294_Q	394_F	1.639	1.00
89_L	187_A	1.635	1.00
370_L	379_I	1.631	1.00
309_M	369_L	1.627	1.00
73_R	113_D	1.626	1.00
306_G	352_A	1.623	1.00
189_A	204_L	1.622	1.00
78_G	191_I	1.603	1.00
399_D	402_S	1.599	1.00
395_D	399_D	1.585	1.00
80_R	109_A	1.573	1.00
292_Y	400_A	1.571	1.00
208_R	211_T	1.567	1.00
298_Y	302_V	1.566	1.00
64_P	67_E	1.566	1.00
303_N	307_E	1.566	1.00
350_R	371_L	1.563	1.00
112_I	164_A	1.562	1.00
273_I	301_F	1.558	1.00
278_V	309_M	1.556	1.00
304_R	307_E	1.543	1.00
331_A	363_Y	1.525	1.00
57_Q	61_E	1.520	1.00
77_A	81_E	1.516	1.00
339_Q	378_S	1.514	1.00
378_S	382_E	1.511	1.00
74_K	77_A	1.508	1.00
172_T	201_V	1.505	1.00
266_L	304_R	1.499	1.00
270_V	304_R	1.485	1.00
23_W	37_R	1.482	1.00
47_R	219_N	1.481	1.00
67_E	70_S	1.472	1.00
299_D	393_A	1.465	1.00
261_M	422_V	1.450	1.00
73_R	120_R	1.444	1.00
291_V	389_L	1.444	1.00
190_K	194_E	1.442	1.00
62_A	429_G	1.438	1.00
292_Y	394_F	1.431	1.00
88_A	92_E	1.426	1.00
33_A	361_K	1.419	1.00
351_V	370_L	1.417	1.00
63_L	67_E	1.416	1.00
32_E	361_K	1.413	1.00
272_A	416_Y	1.413	1.00
308_A	311_A	1.408	1.00
76_S	113_D	1.405	1.00
300_Q	303_N	1.403	1.00
293_V	301_F	1.402	1.00
84_S	88_A	1.401	1.00
313_Q	322_D	1.400	1.00
273_I	291_V	1.396	1.00
342_A	345_V	1.396	1.00
398_E	429_G	1.395	1.00
399_D	403_M	1.394	1.00
262_D	422_V	1.377	1.00
27_V	34_V	1.376	1.00
112_I	160_A	1.375	1.00
413_S	432_F	1.375	1.00
139_F	428_K	1.374	1.00
118_W	121_R	1.372	1.00
45_D	48_K	1.356	1.00
82_R	187_A	1.341	1.00
22_A	40_D	1.339	1.00
148_G	173_I	1.338	1.00
298_Y	371_L	1.330	1.00
337_V	386_G	1.329	1.00
214_Q	240_T	1.318	1.00
238_M	457_I	1.318	1.00
334_L	338_E	1.313	1.00
77_A	113_D	1.309	1.00
335_E	339_Q	1.308	1.00
224_M	249_C	1.303	1.00
340_K	384_T	1.296	1.00
88_A	318_A	1.286	1.00
347_E	378_S	1.282	1.00
394_F	403_M	1.280	1.00
91_V	101_A	1.279	1.00
299_D	303_N	1.278	1.00
261_M	394_F	1.274	1.00
28_N	31_T	1.269	1.00
159_I	175_I	1.262	1.00
334_L	357_A	1.260	1.00
334_L	365_Y	1.258	1.00
302_V	306_G	1.257	1.00
307_E	310_Q	1.256	1.00
331_A	334_L	1.252	1.00
218_G	243_K	1.251	1.00
57_Q	172_T	1.247	1.00
189_A	202_F	1.246	1.00
261_M	426_A	1.244	1.00
310_Q	353_F	1.236	1.00
98_Q	102_E	1.235	1.00
259_I	400_A	1.228	1.00
43_A	215_E	1.227	1.00
297_I	300_Q	1.220	1.00
50_I	219_N	1.216	1.00
376_E	381_H	1.213	1.00
294_Q	396_T	1.209	1.00
40_D	208_R	1.206	1.00
76_S	80_R	1.206	1.00
401_I	426_A	1.205	1.00
316_N	319_E	1.197	1.00
51_D	55_R	1.196	1.00
315_G	323_I	1.192	1.00
307_E	311_A	1.189	1.00
464_H	467_H	1.189	1.00
313_Q	324_A	1.186	1.00
294_Q	297_I	1.182	1.00
304_R	308_A	1.182	1.00
463_K	467_H	1.178	1.00
88_A	98_Q	1.177	1.00
396_T	399_D	1.173	1.00
137_L	424_M	1.173	1.00
339_Q	343_R	1.163	1.00
140_K	472_T	1.162	1.00
192_V	202_F	1.157	1.00
179_E	208_R	1.157	1.00
214_Q	236_K	1.152	1.00
63_L	71_W	1.152	1.00
179_E	209_G	1.152	1.00
46_A	212_V	1.144	1.00
398_E	425_K	1.136	1.00
91_V	317_P	1.135	1.00
375_Q	406_D	1.133	1.00
413_S	435_T	1.133	1.00
50_I	222_V	1.130	1.00
305_L	389_L	1.128	1.00
427_I	475_V	1.127	1.00
86_I	187_A	1.122	1.00
200_G	203_N	1.118	1.00
236_K	240_T	1.117	1.00
301_F	305_L	1.112	1.00
349_A	370_L	1.111	1.00
143_L	224_M	1.111	1.00
423_A	437_I	1.109	1.00
381_H	408_D	1.104	1.00
50_I	221_K	1.102	1.00
74_K	78_G	1.101	1.00
232_S	236_K	1.096	1.00
302_V	371_L	1.095	1.00
186_I	206_L	1.094	1.00
302_V	352_A	1.094	1.00
233_A	236_K	1.091	1.00
83_A	102_E	1.090	1.00
52_A	203_N	1.083	1.00
125_E	463_K	1.083	1.00
398_E	402_S	1.082	1.00
24_I	40_D	1.079	1.00
73_R	117_E	1.074	1.00
75_I	191_I	1.067	1.00
344_A	370_L	1.067	1.00
358_V	366_P	1.067	1.00
238_M	248_V	1.066	1.00
163_M	202_F	1.065	1.00
36_S	183_N	1.064	1.00
258_A	288_A	1.062	1.00
265_D	418_Q	1.059	1.00
215_E	219_N	1.055	1.00
381_H	406_D	1.053	1.00
148_G	226_S	1.047	1.00
259_I	426_A	1.046	1.00
75_I	197_L	1.046	1.00
28_N	316_N	1.045	1.00
464_H	472_T	1.045	1.00
397_L	426_A	1.040	1.00
401_I	429_G	1.040	1.00
75_I	112_I	1.038	1.00
347_E	377_M	1.038	1.00
306_G	353_F	1.037	1.00
310_Q	366_P	1.037	1.00
163_M	173_I	1.034	1.00
40_D	211_T	1.034	1.00
259_I	404_A	1.032	1.00
147_T	216_L	1.032	1.00
147_T	222_V	1.025	1.00
30_A	317_P	1.024	1.00
419_N	422_V	1.017	1.00
394_F	400_A	1.012	1.00
125_E	464_H	1.002	1.00
312_V	325_M	1.001	1.00
154_F	284_V	1.000	1.00
86_I	191_I	0.994	1.00
43_A	211_T	0.994	1.00
343_R	346_E	0.990	1.00
334_L	363_Y	0.988	1.00
265_D	268_L	0.987	1.00
108_T	160_A	0.984	1.00
56_A	172_T	0.982	1.00
32_E	363_Y	0.981	1.00
235_E	245_I	0.980	1.00
82_R	191_I	0.972	1.00
255_K	289_E	0.972	1.00
69_A	120_R	0.971	1.00
58_P	402_S	0.970	1.00
145_V	172_T	0.970	1.00
81_E	194_E	0.965	1.00
54_E	58_P	0.964	1.00
459_G	471_Q	0.961	1.00
452_W	471_Q	0.957	1.00
58_P	431_K	0.956	1.00
28_N	92_E	0.954	1.00
85_E	88_A	0.954	1.00
268_L	272_A	0.952	1.00
73_R	116_A	0.951	1.00
190_K	193_D	0.950	1.00
337_V	388_V	0.949	1.00
274_V	308_A	0.948	1.00
139_F	475_V	0.943	1.00
119_A	168_L	0.942	1.00
339_Q	342_A	0.942	1.00
186_I	204_L	0.941	1.00
402_S	406_D	0.933	1.00
143_L	247_K	0.932	1.00
238_M	242_A	0.931	1.00
340_K	343_R	0.930	1.00
373_V	377_M	0.930	1.00
82_R	190_K	0.930	1.00
43_A	47_R	0.929	1.00
267_E	300_Q	0.927	1.00
354_G	366_P	0.926	1.00
450_A	459_G	0.925	1.00
276_S	288_A	0.924	1.00
257_P	413_S	0.924	1.00
92_E	318_A	0.916	1.00
354_G	368_T	0.916	1.00
414_S	440_E	0.913	1.00
78_G	82_R	0.912	1.00
136_I	447_G	0.911	1.00
70_S	74_K	0.904	1.00
146_T	224_M	0.896	1.00
141_R	428_K	0.894	1.00
277_R	289_E	0.894	1.00
266_L	270_V	0.894	1.00
141_R	452_W	0.891	1.00
235_E	239_A	0.889	1.00
108_T	156_F	0.889	1.00
258_A	416_Y	0.886	1.00
69_A	73_R	0.886	1.00
223_A	431_K	0.884	1.00
61_E	431_K	0.883	1.00
58_P	62_A	0.879	1.00
180_F	332_A	0.877	1.00
48_K	52_A	0.873	1.00
96_K	104_E	0.872	1.00
28_N	33_A	0.872	1.00
65_A	69_A	0.872	1.00
299_D	302_V	0.869	1.00
27_V	363_Y	0.869	1.00
46_A	147_T	0.869	1.00
94_G	181_T	0.868	1.00
298_Y	391_V	0.868	1.00
261_M	417_T	0.864	1.00
76_S	116_A	0.862	1.00
62_A	428_K	0.860	1.00
392_V	403_M	0.859	1.00
145_V	222_V	0.859	1.00
189_A	193_D	0.858	1.00
424_M	428_K	0.858	1.00
261_M	397_L	0.858	1.00
238_M	241_A	0.857	1.00
270_V	305_L	0.856	1.00
335_E	338_E	0.856	1.00
247_K	471_Q	0.851	1.00
270_V	308_A	0.848	1.00
447_G	474_V	0.848	1.00
230_S	233_A	0.847	1.00
345_V	370_L	0.841	1.00
225_V	241_A	0.840	1.00
337_V	384_T	0.840	1.00
79_I	108_T	0.837	1.00
349_A	377_M	0.837	1.00
340_K	378_S	0.834	1.00
30_A	364_Y	0.833	1.00
186_I	190_K	0.833	1.00
375_Q	392_V	0.829	1.00
413_S	430_L	0.828	1.00
24_I	208_R	0.826	1.00
169_T	470_L	0.822	1.00
60_W	201_V	0.817	1.00
162_K	460_A	0.817	1.00
303_N	306_G	0.816	1.00
69_A	116_A	0.816	1.00
44_E	48_K	0.815	1.00
48_K	51_D	0.815	1.00
348_G	377_M	0.811	1.00
56_A	201_V	0.807	1.00
52_A	200_G	0.806	1.00
400_A	403_M	0.806	1.00
415_I	426_A	0.802	1.00
420_L	423_A	0.802	1.00
269_A	273_I	0.802	1.00
44_E	47_R	0.802	1.00
175_I	185_A	0.801	1.00
41_G	45_D	0.801	1.00
355_G	368_T	0.799	1.00
165_P	465_G	0.798	1.00
238_M	245_I	0.798	1.00
270_V	301_F	0.798	1.00
53_A	203_N	0.795	1.00
159_I	163_M	0.794	1.00
401_I	405_N	0.794	1.00
143_L	171_N	0.794	1.00
143_L	471_Q	0.793	1.00
166_A	173_I	0.793	1.00
234_G	252_L	0.791	1.00
394_F	399_D	0.786	1.00
260_V	301_F	0.785	1.00
99_Q	324_A	0.783	1.00
35_I	92_E	0.782	1.00
432_F	435_T	0.781	1.00
73_R	77_A	0.779	1.00
177_P	206_L	0.777	1.00
225_V	237_I	0.777	1.00
160_A	188_F	0.772	1.00
332_A	335_E	0.771	1.00
66_I	120_R	0.769	1.00
341_V	388_V	0.769	1.00
234_G	250_L	0.766	1.00
344_A	384_T	0.766	1.00
55_R	58_P	0.760	1.00
55_R	59_E	0.759	1.00
71_W	195_I	0.759	1.00
92_E	183_N	0.758	1.00
72_L	168_L	0.757	1.00
217_A	237_I	0.757	1.00
197_L	201_V	0.756	1.00
80_R	83_A	0.755	1.00
314_F	358_V	0.754	1.00
79_I	109_A	0.752	1.00
231_V	454_K	0.749	1.00
305_L	369_L	0.749	1.00
94_G	329_I	0.748	1.00
337_V	365_Y	0.748	1.00
91_V	98_Q	0.747	1.00
266_L	297_I	0.747	1.00
41_G	49_A	0.746	1.00
312_V	324_A	0.746	1.00
156_F	184_N	0.745	1.00
87_S	102_E	0.745	1.00
217_A	240_T	0.744	1.00
345_V	356_K	0.743	1.00
80_R	106_A	0.742	1.00
98_Q	318_A	0.741	1.00
207_G	212_V	0.741	1.00
215_E	218_G	0.736	1.00
197_L	202_F	0.735	1.00
227_M	233_A	0.734	1.00
235_E	243_K	0.734	1.00
147_T	225_V	0.734	1.00
267_E	308_A	0.732	1.00
148_G	162_K	0.732	1.00
256_A	289_E	0.732	1.00
87_S	98_Q	0.731	1.00
241_A	248_V	0.731	1.00
257_P	404_A	0.729	1.00
28_N	318_A	0.729	1.00
298_Y	372_D	0.728	1.00
269_A	301_F	0.728	1.00
294_Q	397_L	0.726	1.00
58_P	61_E	0.723	1.00
59_E	63_L	0.721	1.00
340_K	382_E	0.720	1.00
87_S	91_V	0.714	1.00
320_R	323_I	0.714	1.00
309_M	353_F	0.713	1.00
270_V	274_V	0.712	1.00
136_I	474_V	0.711	1.00
74_K	195_I	0.711	1.00
102_E	106_A	0.707	1.00
217_A	225_V	0.706	1.00
22_A	211_T	0.702	1.00
306_G	309_M	0.701	1.00
418_Q	421_N	0.700	1.00
293_V	297_I	0.698	1.00
143_L	223_A	0.697	1.00
336_R	339_Q	0.697	1.00
180_F	329_I	0.697	1.00
53_A	172_T	0.694	1.00
175_I	202_F	0.693	1.00
27_V	32_E	0.692	1.00
46_A	215_E	0.689	1.00
84_S	98_Q	0.689	1.00
330_N	333_A	0.688	1.00
85_E	190_K	0.688	1.00
240_T	243_K	0.687	1.00
150_L	159_I	0.687	1.00
159_I	185_A	0.686	1.00
333_A	336_R	0.685	1.00
47_R	221_K	0.683	1.00
60_W	71_W	0.680	1.00
274_V	305_L	0.680	1.00
371_L	393_A	0.679	1.00
89_L	183_N	0.678	1.00
319_E	323_I	0.675	1.00
54_E	57_Q	0.672	1.00
32_E	331_A	0.672	1.00
179_E	336_R	0.670	1.00
281_S	325_M	0.670	1.00
261_M	294_Q	0.670	1.00
46_A	50_I	0.669	1.00
61_E	429_G	0.669	1.00
427_I	437_I	0.668	1.00
292_Y	380_M	0.667	1.00
274_V	312_V	0.665	1.00
147_T	213_G	0.662	1.00
247_K	468_E	0.660	1.00
77_A	80_R	0.659	1.00
239_A	242_A	0.658	1.00
65_A	119_A	0.658	1.00
263_D	417_T	0.658	1.00
292_Y	375_Q	0.658	1.00
309_M	312_V	0.656	1.00
171_N	470_L	0.654	1.00
260_V	269_A	0.654	1.00
420_L	424_M	0.652	1.00
159_I	188_F	0.651	1.00
90_I	93_E	0.651	1.00
76_S	109_A	0.650	1.00
467_H	470_L	0.650	1.00
23_W	39_P	0.649	1.00
135_N	424_M	0.647	1.00
396_T	402_S	0.645	1.00
365_Y	368_T	0.645	1.00
291_V	301_F	0.645	1.00
315_G	319_E	0.643	1.00
59_E	62_A	0.640	1.00
268_L	418_Q	0.639	1.00
314_F	325_M	0.639	1.00
268_L	271_K	0.639	1.00
67_E	71_W	0.638	1.00
331_A	357_A	0.638	1.00
332_A	336_R	0.635	1.00
136_I	476_Y	0.635	1.00
122_Y	470_L	0.635	1.00
467_H	472_T	0.635	1.00
273_I	305_L	0.634	1.00
397_L	401_I	0.634	1.00
179_E	236_K	0.634	1.00
60_W	167_L	0.633	1.00
192_V	197_L	0.633	1.00
375_Q	380_M	0.632	1.00
403_M	406_D	0.631	1.00
431_K	452_W	0.631	1.00
423_A	427_I	0.630	1.00
266_L	300_Q	0.630	1.00
56_A	59_E	0.629	1.00
417_T	422_V	0.627	1.00
52_A	199_R	0.627	1.00
316_N	323_I	0.627	1.00
83_A	87_S	0.625	1.00
61_E	141_R	0.625	1.00
96_K	100_L	0.624	1.00
39_P	206_L	0.622	1.00
58_P	429_G	0.622	1.00
347_E	376_E	0.622	1.00
61_E	142_A	0.620	1.00
334_L	358_V	0.619	1.00
249_C	468_E	0.619	1.00
139_F	473_Q	0.616	1.00
338_E	341_V	0.613	1.00
238_M	250_L	0.612	1.00
305_L	391_V	0.612	1.00
26_V	36_S	0.612	1.00
373_V	380_M	0.611	1.00
373_V	379_I	0.611	1.00
86_I	156_F	0.611	1.00
174_V	203_N	0.610	1.00
162_K	226_S	0.609	1.00
421_N	424_M	0.608	1.00
187_A	191_I	0.606	1.00
341_V	370_L	0.605	1.00
263_D	419_N	0.604	1.00
328_L	333_A	0.604	1.00
105_V	109_A	0.602	1.00
43_A	218_G	0.602	1.00
49_A	205_V	0.599	1.00
88_A	91_V	0.599	1.00
276_S	440_E	0.599	1.00
355_G	366_P	0.598	1.00
90_I	101_A	0.597	1.00
65_A	168_L	0.596	1.00
51_D	54_E	0.596	1.00
163_M	175_I	0.595	1.00
90_I	104_E	0.595	1.00
353_F	369_L	0.595	1.00
26_V	93_E	0.595	1.00
90_I	184_N	0.594	1.00
122_Y	466_L	0.594	1.00
96_K	154_F	0.592	1.00
137_L	475_V	0.590	1.00
79_I	112_I	0.589	1.00
415_I	423_A	0.588	1.00
401_I	425_K	0.588	1.00
35_I	183_N	0.587	1.00
79_I	188_F	0.587	1.00
370_L	373_V	0.586	1.00
211_T	214_Q	0.585	1.00
293_V	298_Y	0.584	1.00
267_E	307_E	0.584	1.00
146_T	171_N	0.583	1.00
421_N	425_K	0.580	1.00
156_F	188_F	0.580	1.00
277_R	389_L	0.578	1.00
41_G	205_V	0.576	1.00
293_V	391_V	0.576	1.00
372_D	393_A	0.575	1.00
384_T	388_V	0.575	1.00
38_I	182_P	0.575	1.00
79_I	156_F	0.574	1.00
207_G	213_G	0.573	1.00
102_E	320_R	0.573	1.00
52_A	56_A	0.573	1.00
91_V	318_A	0.572	1.00
76_S	112_I	0.572	1.00
415_I	437_I	0.571	1.00
224_M	468_E	0.569	1.00
231_V	235_E	0.567	1.00
286_N	444_A	0.566	1.00
400_A	404_A	0.566	1.00
114_Y	118_W	0.566	1.00
375_Q	402_S	0.562	1.00
341_V	368_T	0.560	1.00
258_A	291_V	0.558	1.00
401_I	430_L	0.558	1.00
434_E	443_E	0.556	1.00
306_G	369_L	0.556	1.00
22_A	42_Q	0.556	1.00
404_A	430_L	0.555	1.00
258_A	414_S	0.553	1.00
357_A	366_P	0.553	1.00
172_T	203_N	0.553	1.00
266_L	269_A	0.551	1.00
123_E	126_I	0.550	1.00
106_A	109_A	0.550	1.00
179_E	232_S	0.549	1.00
284_V	287_C	0.549	1.00
266_L	301_F	0.549	1.00
87_S	105_V	0.548	1.00
188_F	192_V	0.548	1.00
351_V	368_T	0.548	1.00
75_I	78_G	0.547	1.00
66_I	70_S	0.546	1.00
145_V	223_A	0.545	1.00
263_D	418_Q	0.545	1.00
291_V	391_V	0.544	1.00
209_G	214_Q	0.544	1.00
49_A	203_N	0.543	1.00
115_M	165_P	0.542	1.00
70_S	73_R	0.542	1.00
54_E	145_V	0.539	1.00
53_A	174_V	0.539	1.00
356_K	359_E	0.539	1.00
105_V	156_F	0.538	1.00
146_T	173_I	0.537	1.00
379_I	384_T	0.536	1.00
65_A	123_E	0.534	1.00
167_L	202_F	0.534	1.00
436_Y	439_R	0.533	1.00
314_F	324_A	0.532	1.00
397_L	429_G	0.530	1.00
262_D	394_F	0.530	1.00
264_A	269_A	0.530	1.00
26_V	182_P	0.529	1.00
169_T	466_L	0.529	1.00
431_K	471_Q	0.529	1.00
130_D	136_I	0.528	1.00
94_G	280_N	0.528	1.00
157_F	161_R	0.528	1.00
217_A	244_N	0.527	1.00
213_G	217_A	0.524	1.00
256_A	412_T	0.524	1.00
141_R	431_K	0.523	1.00
336_R	340_K	0.522	1.00
351_V	355_G	0.522	1.00
79_I	86_I	0.522	1.00
338_E	345_V	0.522	1.00
87_S	101_A	0.522	1.00
248_V	457_I	0.521	1.00
193_D	200_G	0.521	1.00
118_W	463_K	0.520	1.00
86_I	105_V	0.520	1.00
295_K	298_Y	0.520	1.00
270_V	297_I	0.519	1.00
351_V	354_G	0.519	1.00
271_K	275_D	0.519	1.00
232_S	332_A	0.518	1.00
435_T	473_Q	0.518	1.00
117_E	120_R	0.517	1.00
426_A	430_L	0.517	1.00
148_G	163_M	0.516	1.00
53_A	145_V	0.516	1.00
278_V	312_V	0.516	1.00
83_A	109_A	0.515	1.00
38_I	183_N	0.515	1.00
352_A	372_D	0.514	1.00
327_P	364_Y	0.513	1.00
107_F	157_F	0.512	1.00
288_A	414_S	0.512	1.00
40_D	179_E	0.512	1.00
71_W	75_I	0.511	1.00
328_L	365_Y	0.511	1.00
226_S	469_Y	0.510	1.00
242_A	245_I	0.509	1.00
305_L	309_M	0.507	1.00
347_E	374_R	0.506	1.00
167_L	197_L	0.506	1.00
402_S	429_G	0.504	1.00
211_T	215_E	0.502	1.00
161_R	461_D	0.501	1.00
26_V	35_I	0.500	1.00
43_A	214_Q	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4o5hA	4	0.9979	100	0.014	Contact Map
4qf6A	4	0.9958	100	0.017	Contact Map
4yweA	5	0.9812	100	0.019	Contact Map
4qtoA	4	0.9979	100	0.019	Contact Map
3u4jA	4	0.9979	100	0.021	Contact Map
3ek1A	5	0.9937	100	0.021	Contact Map
4pxlA	4	0.9937	100	0.021	Contact Map
2o2pA	5	0.9979	100	0.023	Contact Map
1a4sA	4	0.9937	100	0.023	Contact Map
2d4eA	4	0.9937	100	0.024	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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