GREMLIN Database
ALDA - Lactaldehyde dehydrogenase
UniProt: P25553 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10035
Length: 479 (453)
Sequences: 36456 (21944)
Seq/√Len: 1031.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
295_K395_D4.9941.00
239_A243_K3.9931.00
295_K393_A3.1531.00
267_E304_R3.0901.00
298_Y393_A2.9511.00
25_D37_R2.8421.00
356_K366_P2.7841.00
54_E221_K2.7611.00
262_D294_Q2.7251.00
374_R377_M2.6661.00
331_A335_E2.6331.00
271_K308_A2.5821.00
343_R378_S2.5811.00
187_A190_K2.5401.00
342_A346_E2.4981.00
302_V391_V2.4941.00
262_D296_G2.4651.00
82_R85_E2.4031.00
80_R113_D2.3561.00
25_D34_V2.3511.00
417_T423_A2.3471.00
193_D199_R2.2301.00
42_Q45_D2.2071.00
54_E223_A2.1991.00
341_V365_Y2.1981.00
319_E322_D2.1861.00
83_A106_A2.1591.00
338_E342_A2.1581.00
75_I192_V2.1191.00
78_G194_E2.1131.00
408_D454_K2.0651.00
397_L422_V2.0621.00
343_R347_E2.0191.00
218_G240_T2.0161.00
214_Q218_G2.0111.00
180_F330_N1.9971.00
350_R372_D1.9781.00
141_R473_Q1.9751.00
338_E357_A1.9681.00
306_G310_Q1.9291.00
258_A273_I1.9211.00
425_K429_G1.9201.00
85_E187_A1.9161.00
328_L337_V1.9091.00
300_Q304_R1.9081.00
338_E365_Y1.9071.00
140_K467_H1.8961.00
352_A371_L1.8491.00
71_W197_L1.8481.00
47_R215_E1.8461.00
236_K239_A1.8361.00
263_D422_V1.8231.00
235_E454_K1.8101.00
51_D221_K1.8071.00
345_V351_V1.7861.00
78_G81_E1.7811.00
292_Y403_M1.7681.00
84_S102_E1.7671.00
82_R194_E1.7631.00
380_M392_V1.7351.00
431_K453_R1.7111.00
78_G195_I1.7101.00
397_L425_K1.7031.00
47_R51_D1.6971.00
140_K470_L1.6881.00
34_V37_R1.6861.00
375_Q403_M1.6481.00
294_Q394_F1.6391.00
89_L187_A1.6351.00
370_L379_I1.6311.00
309_M369_L1.6271.00
73_R113_D1.6261.00
306_G352_A1.6231.00
189_A204_L1.6221.00
78_G191_I1.6031.00
399_D402_S1.5991.00
395_D399_D1.5851.00
80_R109_A1.5731.00
292_Y400_A1.5711.00
208_R211_T1.5671.00
298_Y302_V1.5661.00
64_P67_E1.5661.00
303_N307_E1.5661.00
350_R371_L1.5631.00
112_I164_A1.5621.00
273_I301_F1.5581.00
278_V309_M1.5561.00
304_R307_E1.5431.00
331_A363_Y1.5251.00
57_Q61_E1.5201.00
77_A81_E1.5161.00
339_Q378_S1.5141.00
378_S382_E1.5111.00
74_K77_A1.5081.00
172_T201_V1.5051.00
266_L304_R1.4991.00
270_V304_R1.4851.00
23_W37_R1.4821.00
47_R219_N1.4811.00
67_E70_S1.4721.00
299_D393_A1.4651.00
261_M422_V1.4501.00
73_R120_R1.4441.00
291_V389_L1.4441.00
190_K194_E1.4421.00
62_A429_G1.4381.00
292_Y394_F1.4311.00
88_A92_E1.4261.00
33_A361_K1.4191.00
351_V370_L1.4171.00
63_L67_E1.4161.00
32_E361_K1.4131.00
272_A416_Y1.4131.00
308_A311_A1.4081.00
76_S113_D1.4051.00
300_Q303_N1.4031.00
293_V301_F1.4021.00
84_S88_A1.4011.00
313_Q322_D1.4001.00
273_I291_V1.3961.00
342_A345_V1.3961.00
398_E429_G1.3951.00
399_D403_M1.3941.00
262_D422_V1.3771.00
27_V34_V1.3761.00
112_I160_A1.3751.00
413_S432_F1.3751.00
139_F428_K1.3741.00
118_W121_R1.3721.00
45_D48_K1.3561.00
82_R187_A1.3411.00
22_A40_D1.3391.00
148_G173_I1.3381.00
298_Y371_L1.3301.00
337_V386_G1.3291.00
214_Q240_T1.3181.00
238_M457_I1.3181.00
334_L338_E1.3131.00
77_A113_D1.3091.00
335_E339_Q1.3081.00
224_M249_C1.3031.00
340_K384_T1.2961.00
88_A318_A1.2861.00
347_E378_S1.2821.00
394_F403_M1.2801.00
91_V101_A1.2791.00
299_D303_N1.2781.00
261_M394_F1.2741.00
28_N31_T1.2691.00
159_I175_I1.2621.00
334_L357_A1.2601.00
334_L365_Y1.2581.00
302_V306_G1.2571.00
307_E310_Q1.2561.00
331_A334_L1.2521.00
218_G243_K1.2511.00
57_Q172_T1.2471.00
189_A202_F1.2461.00
261_M426_A1.2441.00
310_Q353_F1.2361.00
98_Q102_E1.2351.00
259_I400_A1.2281.00
43_A215_E1.2271.00
297_I300_Q1.2201.00
50_I219_N1.2161.00
376_E381_H1.2131.00
294_Q396_T1.2091.00
40_D208_R1.2061.00
76_S80_R1.2061.00
401_I426_A1.2051.00
316_N319_E1.1971.00
51_D55_R1.1961.00
315_G323_I1.1921.00
307_E311_A1.1891.00
464_H467_H1.1891.00
313_Q324_A1.1861.00
294_Q297_I1.1821.00
304_R308_A1.1821.00
463_K467_H1.1781.00
88_A98_Q1.1771.00
396_T399_D1.1731.00
137_L424_M1.1731.00
339_Q343_R1.1631.00
140_K472_T1.1621.00
192_V202_F1.1571.00
179_E208_R1.1571.00
214_Q236_K1.1521.00
63_L71_W1.1521.00
179_E209_G1.1521.00
46_A212_V1.1441.00
398_E425_K1.1361.00
91_V317_P1.1351.00
375_Q406_D1.1331.00
413_S435_T1.1331.00
50_I222_V1.1301.00
305_L389_L1.1281.00
427_I475_V1.1271.00
86_I187_A1.1221.00
200_G203_N1.1181.00
236_K240_T1.1171.00
301_F305_L1.1121.00
349_A370_L1.1111.00
143_L224_M1.1111.00
423_A437_I1.1091.00
381_H408_D1.1041.00
50_I221_K1.1021.00
74_K78_G1.1011.00
232_S236_K1.0961.00
302_V371_L1.0951.00
186_I206_L1.0941.00
302_V352_A1.0941.00
233_A236_K1.0911.00
83_A102_E1.0901.00
52_A203_N1.0831.00
125_E463_K1.0831.00
398_E402_S1.0821.00
24_I40_D1.0791.00
73_R117_E1.0741.00
75_I191_I1.0671.00
344_A370_L1.0671.00
358_V366_P1.0671.00
238_M248_V1.0661.00
163_M202_F1.0651.00
36_S183_N1.0641.00
258_A288_A1.0621.00
265_D418_Q1.0591.00
215_E219_N1.0551.00
381_H406_D1.0531.00
148_G226_S1.0471.00
259_I426_A1.0461.00
75_I197_L1.0461.00
28_N316_N1.0451.00
464_H472_T1.0451.00
397_L426_A1.0401.00
401_I429_G1.0401.00
75_I112_I1.0381.00
347_E377_M1.0381.00
306_G353_F1.0371.00
310_Q366_P1.0371.00
163_M173_I1.0341.00
40_D211_T1.0341.00
259_I404_A1.0321.00
147_T216_L1.0321.00
147_T222_V1.0251.00
30_A317_P1.0241.00
419_N422_V1.0171.00
394_F400_A1.0121.00
125_E464_H1.0021.00
312_V325_M1.0011.00
154_F284_V1.0001.00
86_I191_I0.9941.00
43_A211_T0.9941.00
343_R346_E0.9901.00
334_L363_Y0.9881.00
265_D268_L0.9871.00
108_T160_A0.9841.00
56_A172_T0.9821.00
32_E363_Y0.9811.00
235_E245_I0.9801.00
82_R191_I0.9721.00
255_K289_E0.9721.00
69_A120_R0.9711.00
58_P402_S0.9701.00
145_V172_T0.9701.00
81_E194_E0.9651.00
54_E58_P0.9641.00
459_G471_Q0.9611.00
452_W471_Q0.9571.00
58_P431_K0.9561.00
28_N92_E0.9541.00
85_E88_A0.9541.00
268_L272_A0.9521.00
73_R116_A0.9511.00
190_K193_D0.9501.00
337_V388_V0.9491.00
274_V308_A0.9481.00
139_F475_V0.9431.00
119_A168_L0.9421.00
339_Q342_A0.9421.00
186_I204_L0.9411.00
402_S406_D0.9331.00
143_L247_K0.9321.00
238_M242_A0.9311.00
340_K343_R0.9301.00
373_V377_M0.9301.00
82_R190_K0.9301.00
43_A47_R0.9291.00
267_E300_Q0.9271.00
354_G366_P0.9261.00
450_A459_G0.9251.00
276_S288_A0.9241.00
257_P413_S0.9241.00
92_E318_A0.9161.00
354_G368_T0.9161.00
414_S440_E0.9131.00
78_G82_R0.9121.00
136_I447_G0.9111.00
70_S74_K0.9041.00
146_T224_M0.8961.00
141_R428_K0.8941.00
277_R289_E0.8941.00
266_L270_V0.8941.00
141_R452_W0.8911.00
235_E239_A0.8891.00
108_T156_F0.8891.00
258_A416_Y0.8861.00
69_A73_R0.8861.00
223_A431_K0.8841.00
61_E431_K0.8831.00
58_P62_A0.8791.00
180_F332_A0.8771.00
48_K52_A0.8731.00
96_K104_E0.8721.00
28_N33_A0.8721.00
65_A69_A0.8721.00
299_D302_V0.8691.00
27_V363_Y0.8691.00
46_A147_T0.8691.00
94_G181_T0.8681.00
298_Y391_V0.8681.00
261_M417_T0.8641.00
76_S116_A0.8621.00
62_A428_K0.8601.00
392_V403_M0.8591.00
145_V222_V0.8591.00
189_A193_D0.8581.00
424_M428_K0.8581.00
261_M397_L0.8581.00
238_M241_A0.8571.00
270_V305_L0.8561.00
335_E338_E0.8561.00
247_K471_Q0.8511.00
270_V308_A0.8481.00
447_G474_V0.8481.00
230_S233_A0.8471.00
345_V370_L0.8411.00
225_V241_A0.8401.00
337_V384_T0.8401.00
79_I108_T0.8371.00
349_A377_M0.8371.00
340_K378_S0.8341.00
30_A364_Y0.8331.00
186_I190_K0.8331.00
375_Q392_V0.8291.00
413_S430_L0.8281.00
24_I208_R0.8261.00
169_T470_L0.8221.00
60_W201_V0.8171.00
162_K460_A0.8171.00
303_N306_G0.8161.00
69_A116_A0.8161.00
44_E48_K0.8151.00
48_K51_D0.8151.00
348_G377_M0.8111.00
56_A201_V0.8071.00
52_A200_G0.8061.00
400_A403_M0.8061.00
415_I426_A0.8021.00
420_L423_A0.8021.00
269_A273_I0.8021.00
44_E47_R0.8021.00
175_I185_A0.8011.00
41_G45_D0.8011.00
355_G368_T0.7991.00
165_P465_G0.7981.00
238_M245_I0.7981.00
270_V301_F0.7981.00
53_A203_N0.7951.00
159_I163_M0.7941.00
401_I405_N0.7941.00
143_L171_N0.7941.00
143_L471_Q0.7931.00
166_A173_I0.7931.00
234_G252_L0.7911.00
394_F399_D0.7861.00
260_V301_F0.7851.00
99_Q324_A0.7831.00
35_I92_E0.7821.00
432_F435_T0.7811.00
73_R77_A0.7791.00
177_P206_L0.7771.00
225_V237_I0.7771.00
160_A188_F0.7721.00
332_A335_E0.7711.00
66_I120_R0.7691.00
341_V388_V0.7691.00
234_G250_L0.7661.00
344_A384_T0.7661.00
55_R58_P0.7601.00
55_R59_E0.7591.00
71_W195_I0.7591.00
92_E183_N0.7581.00
72_L168_L0.7571.00
217_A237_I0.7571.00
197_L201_V0.7561.00
80_R83_A0.7551.00
314_F358_V0.7541.00
79_I109_A0.7521.00
231_V454_K0.7491.00
305_L369_L0.7491.00
94_G329_I0.7481.00
337_V365_Y0.7481.00
91_V98_Q0.7471.00
266_L297_I0.7471.00
41_G49_A0.7461.00
312_V324_A0.7461.00
156_F184_N0.7451.00
87_S102_E0.7451.00
217_A240_T0.7441.00
345_V356_K0.7431.00
80_R106_A0.7421.00
98_Q318_A0.7411.00
207_G212_V0.7411.00
215_E218_G0.7361.00
197_L202_F0.7351.00
227_M233_A0.7341.00
235_E243_K0.7341.00
147_T225_V0.7341.00
267_E308_A0.7321.00
148_G162_K0.7321.00
256_A289_E0.7321.00
87_S98_Q0.7311.00
241_A248_V0.7311.00
257_P404_A0.7291.00
28_N318_A0.7291.00
298_Y372_D0.7281.00
269_A301_F0.7281.00
294_Q397_L0.7261.00
58_P61_E0.7231.00
59_E63_L0.7211.00
340_K382_E0.7201.00
87_S91_V0.7141.00
320_R323_I0.7141.00
309_M353_F0.7131.00
270_V274_V0.7121.00
136_I474_V0.7111.00
74_K195_I0.7111.00
102_E106_A0.7071.00
217_A225_V0.7061.00
22_A211_T0.7021.00
306_G309_M0.7011.00
418_Q421_N0.7001.00
293_V297_I0.6981.00
143_L223_A0.6971.00
336_R339_Q0.6971.00
180_F329_I0.6971.00
53_A172_T0.6941.00
175_I202_F0.6931.00
27_V32_E0.6921.00
46_A215_E0.6891.00
84_S98_Q0.6891.00
330_N333_A0.6881.00
85_E190_K0.6881.00
240_T243_K0.6871.00
150_L159_I0.6871.00
159_I185_A0.6861.00
333_A336_R0.6851.00
47_R221_K0.6831.00
60_W71_W0.6801.00
274_V305_L0.6801.00
371_L393_A0.6791.00
89_L183_N0.6781.00
319_E323_I0.6751.00
54_E57_Q0.6721.00
32_E331_A0.6721.00
179_E336_R0.6701.00
281_S325_M0.6701.00
261_M294_Q0.6701.00
46_A50_I0.6691.00
61_E429_G0.6691.00
427_I437_I0.6681.00
292_Y380_M0.6671.00
274_V312_V0.6651.00
147_T213_G0.6621.00
247_K468_E0.6601.00
77_A80_R0.6591.00
239_A242_A0.6581.00
65_A119_A0.6581.00
263_D417_T0.6581.00
292_Y375_Q0.6581.00
309_M312_V0.6561.00
171_N470_L0.6541.00
260_V269_A0.6541.00
420_L424_M0.6521.00
159_I188_F0.6511.00
90_I93_E0.6511.00
76_S109_A0.6501.00
467_H470_L0.6501.00
23_W39_P0.6491.00
135_N424_M0.6471.00
396_T402_S0.6451.00
365_Y368_T0.6451.00
291_V301_F0.6451.00
315_G319_E0.6431.00
59_E62_A0.6401.00
268_L418_Q0.6391.00
314_F325_M0.6391.00
268_L271_K0.6391.00
67_E71_W0.6381.00
331_A357_A0.6381.00
332_A336_R0.6351.00
136_I476_Y0.6351.00
122_Y470_L0.6351.00
467_H472_T0.6351.00
273_I305_L0.6341.00
397_L401_I0.6341.00
179_E236_K0.6341.00
60_W167_L0.6331.00
192_V197_L0.6331.00
375_Q380_M0.6321.00
403_M406_D0.6311.00
431_K452_W0.6311.00
423_A427_I0.6301.00
266_L300_Q0.6301.00
56_A59_E0.6291.00
417_T422_V0.6271.00
52_A199_R0.6271.00
316_N323_I0.6271.00
83_A87_S0.6251.00
61_E141_R0.6251.00
96_K100_L0.6241.00
39_P206_L0.6221.00
58_P429_G0.6221.00
347_E376_E0.6221.00
61_E142_A0.6201.00
334_L358_V0.6191.00
249_C468_E0.6191.00
139_F473_Q0.6161.00
338_E341_V0.6131.00
238_M250_L0.6121.00
305_L391_V0.6121.00
26_V36_S0.6121.00
373_V380_M0.6111.00
373_V379_I0.6111.00
86_I156_F0.6111.00
174_V203_N0.6101.00
162_K226_S0.6091.00
421_N424_M0.6081.00
187_A191_I0.6061.00
341_V370_L0.6051.00
263_D419_N0.6041.00
328_L333_A0.6041.00
105_V109_A0.6021.00
43_A218_G0.6021.00
49_A205_V0.5991.00
88_A91_V0.5991.00
276_S440_E0.5991.00
355_G366_P0.5981.00
90_I101_A0.5971.00
65_A168_L0.5961.00
51_D54_E0.5961.00
163_M175_I0.5951.00
90_I104_E0.5951.00
353_F369_L0.5951.00
26_V93_E0.5951.00
90_I184_N0.5941.00
122_Y466_L0.5941.00
96_K154_F0.5921.00
137_L475_V0.5901.00
79_I112_I0.5891.00
415_I423_A0.5881.00
401_I425_K0.5881.00
35_I183_N0.5871.00
79_I188_F0.5871.00
370_L373_V0.5861.00
211_T214_Q0.5851.00
293_V298_Y0.5841.00
267_E307_E0.5841.00
146_T171_N0.5831.00
421_N425_K0.5801.00
156_F188_F0.5801.00
277_R389_L0.5781.00
41_G205_V0.5761.00
293_V391_V0.5761.00
372_D393_A0.5751.00
384_T388_V0.5751.00
38_I182_P0.5751.00
79_I156_F0.5741.00
207_G213_G0.5731.00
102_E320_R0.5731.00
52_A56_A0.5731.00
91_V318_A0.5721.00
76_S112_I0.5721.00
415_I437_I0.5711.00
224_M468_E0.5691.00
231_V235_E0.5671.00
286_N444_A0.5661.00
400_A404_A0.5661.00
114_Y118_W0.5661.00
375_Q402_S0.5621.00
341_V368_T0.5601.00
258_A291_V0.5581.00
401_I430_L0.5581.00
434_E443_E0.5561.00
306_G369_L0.5561.00
22_A42_Q0.5561.00
404_A430_L0.5551.00
258_A414_S0.5531.00
357_A366_P0.5531.00
172_T203_N0.5531.00
266_L269_A0.5511.00
123_E126_I0.5501.00
106_A109_A0.5501.00
179_E232_S0.5491.00
284_V287_C0.5491.00
266_L301_F0.5491.00
87_S105_V0.5481.00
188_F192_V0.5481.00
351_V368_T0.5481.00
75_I78_G0.5471.00
66_I70_S0.5461.00
145_V223_A0.5451.00
263_D418_Q0.5451.00
291_V391_V0.5441.00
209_G214_Q0.5441.00
49_A203_N0.5431.00
115_M165_P0.5421.00
70_S73_R0.5421.00
54_E145_V0.5391.00
53_A174_V0.5391.00
356_K359_E0.5391.00
105_V156_F0.5381.00
146_T173_I0.5371.00
379_I384_T0.5361.00
65_A123_E0.5341.00
167_L202_F0.5341.00
436_Y439_R0.5331.00
314_F324_A0.5321.00
397_L429_G0.5301.00
262_D394_F0.5301.00
264_A269_A0.5301.00
26_V182_P0.5291.00
169_T466_L0.5291.00
431_K471_Q0.5291.00
130_D136_I0.5281.00
94_G280_N0.5281.00
157_F161_R0.5281.00
217_A244_N0.5271.00
213_G217_A0.5241.00
256_A412_T0.5241.00
141_R431_K0.5231.00
336_R340_K0.5221.00
351_V355_G0.5221.00
79_I86_I0.5221.00
338_E345_V0.5221.00
87_S101_A0.5221.00
248_V457_I0.5211.00
193_D200_G0.5211.00
118_W463_K0.5201.00
86_I105_V0.5201.00
295_K298_Y0.5201.00
270_V297_I0.5191.00
351_V354_G0.5191.00
271_K275_D0.5191.00
232_S332_A0.5181.00
435_T473_Q0.5181.00
117_E120_R0.5171.00
426_A430_L0.5171.00
148_G163_M0.5161.00
53_A145_V0.5161.00
278_V312_V0.5161.00
83_A109_A0.5151.00
38_I183_N0.5151.00
352_A372_D0.5141.00
327_P364_Y0.5131.00
107_F157_F0.5121.00
288_A414_S0.5121.00
40_D179_E0.5121.00
71_W75_I0.5111.00
328_L365_Y0.5111.00
226_S469_Y0.5101.00
242_A245_I0.5091.00
305_L309_M0.5071.00
347_E374_R0.5061.00
167_L197_L0.5061.00
402_S429_G0.5041.00
211_T215_E0.5021.00
161_R461_D0.5011.00
26_V35_I0.5001.00
43_A214_Q0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4o5hA 4 0.9979 100 0.014 Contact Map
4qf6A 4 0.9958 100 0.017 Contact Map
4yweA 5 0.9812 100 0.019 Contact Map
4qtoA 4 0.9979 100 0.019 Contact Map
3u4jA 4 0.9979 100 0.021 Contact Map
3ek1A 5 0.9937 100 0.021 Contact Map
4pxlA 4 0.9937 100 0.021 Contact Map
2o2pA 5 0.9979 100 0.023 Contact Map
1a4sA 4 0.9937 100 0.023 Contact Map
2d4eA 4 0.9937 100 0.024 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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