GPPA - ECOLI - GREMLIN Contacts

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GPPA - Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

UniProt:	P25552	Sequences: MGSTSSLYAAIDLGSNSFHMLVVREVAGSIQTLTRIKRKVRLAAGLNSENALSNEAMERGWQCLRLFAERLQDIPPSQIRVVATATLRLAVNAGDFIAKAQEILGCPVQVISGEEEARLIYQGVAHTTGGADQRLVVDIGGASTELVTGTGAQTTSLFSLSMGCVTWLERYFADRNLGQENFDAAEKAAREVLRPVADELRYHGWKVCVGASGTVQALQEIMMAQGMDERITLEKLQQLKQRAIHCGRLEELEIDGLTLERALVFPSGLAILIAIFTELNIQCMTLAGGALREGLVYGMLHLAVEQDIRSRTLRNIQRRFMIDIDQAQRVAKVAANFFDQVENEWHLEAISRDLLISACQLHEIGLSVDFKQAPQHAAYLVRNLDLPGFTPAQKKLLATLLLNQTNPVDLSSLHQQNAVPPRVAEQLCRLLRLAIIFASRRRDDLVPEMTLQANHELLTLTLPQGWLTQHPLGKEIIAQESQWQSYVHWPLEVH	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10413
Length:	494 (479)
Sequences:	2283 (1656)
Seq/√Len:	75.6

ECOLI - GPPA PPX
SULSO - Q97YV9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
339_D	352_R	6.484	1.00
80_R	109_Q	4.826	1.00
51_A	91_V	3.877	1.00
101_Q	107_P	3.794	1.00
335_A	352_R	3.754	1.00
168_L	267_S	3.692	1.00
58_E	62_Q	3.660	1.00
377_A	401_L	3.642	1.00
82_V	295_L	3.597	1.00
348_E	351_S	3.570	1.00
214_T	268_G	3.488	1.00
137_V	275_I	3.466	1.00
100_A	108_V	3.334	1.00
215_V	272_L	3.279	1.00
54_N	99_K	3.252	1.00
230_R	283_C	3.209	1.00
68_A	72_Q	3.061	1.00
351_S	423_V	3.033	1.00
381_V	401_L	3.014	1.00
190_R	274_A	2.973	1.00
47_N	51_A	2.939	1.00
71_L	79_I	2.935	1.00
132_D	150_T	2.918	1.00
331_A	356_I	2.836	1.00
335_A	339_D	2.706	1.00
376_H	379_Y	2.684	1.00
373_A	404_Q	2.598	1.00
221_I	265_F	2.591	1.00
65_R	103_I	2.574	1.00
146_L	275_I	2.454	1.00
210_G	215_V	2.412	1.00
337_F	430_L	2.398	1.00
276_F	284_M	2.386	1.00
115_E	118_R	2.372	1.00
368_V	380_L	2.359	1.00
83_A	87_L	2.328	1.00
309_R	389_F	2.328	1.00
93_A	110_V	2.282	1.00
54_N	58_E	2.271	1.00
95_D	98_A	2.239	1.00
13_L	108_V	2.125	1.00
60_G	96_F	2.102	1.00
81_V	106_C	2.095	1.00
396_L	424_A	2.061	1.00
99_K	103_I	2.043	1.00
100_A	104_L	2.029	1.00
113_G	145_E	2.024	1.00
338_F	352_R	2.004	1.00
192_V	195_P	1.986	1.00
9_A	71_L	1.980	1.00
12_D	16_N	1.968	1.00
96_F	100_A	1.943	1.00
7_L	24_R	1.935	1.00
237_Q	273_I	1.917	1.00
109_Q	115_E	1.897	1.00
313_L	361_L	1.886	1.00
390_T	393_Q	1.884	1.00
23_V	296_V	1.862	1.00
190_R	277_T	1.850	1.00
237_Q	277_T	1.843	1.00
222_M	235_K	1.832	1.00
185_A	189_A	1.831	1.00
392_A	420_P	1.830	1.00
221_I	257_L	1.820	1.00
322_I	364_I	1.815	1.00
331_A	360_Q	1.808	1.00
57_M	92_N	1.805	1.00
94_G	98_A	1.783	1.00
301_H	304_V	1.777	1.00
87_L	96_F	1.765	1.00
13_L	18_F	1.745	1.00
416_Q	419_V	1.744	1.00
453_A	458_L	1.737	1.00
118_R	298_G	1.737	1.00
52_L	96_F	1.728	1.00
34_T	440_R	1.697	1.00
84_T	88_R	1.690	1.00
333_V	438_A	1.688	1.00
9_A	79_I	1.682	1.00
71_L	76_P	1.679	1.00
54_N	95_D	1.679	1.00
22_V	74_I	1.678	1.00
171_Y	188_A	1.665	1.00
474_K	478_A	1.649	1.00
16_N	213_G	1.635	1.00
316_I	364_I	1.609	1.00
228_D	391_P	1.579	0.99
222_M	226_G	1.569	0.99
99_K	102_E	1.563	0.99
79_I	106_C	1.560	0.99
374_P	405_T	1.555	0.99
16_N	261_R	1.545	0.99
53_S	56_A	1.537	0.99
259_L	262_A	1.533	0.99
19_H	290_A	1.527	0.99
233_L	237_Q	1.524	0.99
137_V	284_M	1.518	0.99
357_S	389_F	1.515	0.99
186_E	274_A	1.509	0.99
243_A	265_F	1.501	0.99
317_Q	322_I	1.490	0.99
120_I	212_S	1.478	0.99
403_N	409_D	1.470	0.99
404_Q	435_I	1.468	0.99
113_G	117_A	1.458	0.99
190_R	278_E	1.456	0.99
142_A	166_T	1.436	0.99
212_S	290_A	1.431	0.99
326_Q	329_R	1.421	0.99
189_A	270_A	1.418	0.99
127_T	289_G	1.418	0.99
137_V	208_C	1.414	0.99
247_G	250_E	1.409	0.99
97_I	110_V	1.398	0.99
89_L	166_T	1.396	0.99
193_L	275_I	1.393	0.99
6_S	78_Q	1.391	0.99
12_D	213_G	1.382	0.99
470_H	473_G	1.375	0.98
213_G	261_R	1.367	0.98
208_C	276_F	1.363	0.98
233_L	277_T	1.357	0.98
24_R	31_Q	1.351	0.98
340_Q	451_L	1.346	0.98
132_D	207_V	1.334	0.98
138_D	143_S	1.328	0.98
145_E	159_S	1.326	0.98
422_R	426_Q	1.321	0.98
140_G	143_S	1.318	0.98
231_I	236_L	1.312	0.98
345_W	458_L	1.309	0.98
21_L	293_E	1.303	0.98
429_R	484_Q	1.295	0.98
160_L	196_V	1.288	0.98
331_A	335_A	1.281	0.98
186_E	277_T	1.272	0.97
138_D	261_R	1.259	0.97
326_Q	438_A	1.253	0.97
13_L	83_A	1.252	0.97
454_N	457_L	1.251	0.97
58_E	99_K	1.247	0.97
458_L	484_Q	1.240	0.97
82_V	291_L	1.232	0.97
200_L	204_G	1.227	0.97
18_F	67_F	1.227	0.97
41_R	263_L	1.220	0.97
98_A	102_E	1.216	0.97
118_R	122_Q	1.215	0.97
17_S	37_K	1.215	0.97
225_Q	242_R	1.211	0.97
450_T	461_T	1.204	0.96
237_Q	241_Q	1.200	0.96
180_E	184_A	1.199	0.96
57_M	96_F	1.198	0.96
87_L	100_A	1.192	0.96
250_E	253_E	1.188	0.96
164_C	264_V	1.187	0.96
240_K	269_L	1.186	0.96
361_L	381_V	1.180	0.96
318_R	324_I	1.177	0.96
335_A	356_I	1.170	0.96
18_F	60_G	1.167	0.96
6_S	77_S	1.167	0.96
454_N	459_T	1.160	0.96
178_G	181_N	1.150	0.95
213_G	292_R	1.148	0.95
85_A	166_T	1.147	0.95
452_Q	461_T	1.145	0.95
341_V	430_L	1.144	0.95
117_A	145_E	1.142	0.95
243_A	269_L	1.129	0.95
137_V	144_T	1.126	0.95
19_H	212_S	1.126	0.95
36_I	70_R	1.119	0.95
240_K	244_I	1.116	0.95
313_L	357_S	1.116	0.95
345_W	348_E	1.115	0.94
263_L	266_P	1.114	0.94
396_L	400_L	1.104	0.94
338_F	347_L	1.104	0.94
61_W	100_A	1.100	0.94
345_W	426_Q	1.094	0.94
206_K	282_Q	1.090	0.94
238_Q	242_R	1.079	0.93
12_D	19_H	1.071	0.93
332_K	450_T	1.070	0.93
183_D	186_E	1.066	0.93
144_T	379_Y	1.065	0.93
69_E	72_Q	1.064	0.93
22_V	34_T	1.063	0.93
7_L	76_P	1.060	0.93
211_A	287_A	1.057	0.93
16_N	19_H	1.055	0.93
56_A	90_A	1.054	0.93
132_D	206_K	1.054	0.93
21_L	83_A	1.052	0.93
90_A	93_A	1.049	0.92
128_T	209_V	1.048	0.92
56_A	92_N	1.045	0.92
354_L	396_L	1.044	0.92
182_F	270_A	1.040	0.92
365_G	376_H	1.032	0.92
365_G	380_L	1.031	0.92
41_R	264_V	1.028	0.92
310_S	356_I	1.025	0.92
241_Q	245_H	1.020	0.91
36_I	66_L	1.018	0.91
341_V	345_W	1.013	0.91
114_E	157_L	1.010	0.91
60_G	87_L	1.003	0.91
38_R	66_L	1.002	0.91
261_R	292_R	0.993	0.90
117_A	138_D	0.992	0.90
19_H	292_R	0.990	0.90
233_L	273_I	0.989	0.90
373_A	377_A	0.989	0.90
143_S	261_R	0.986	0.90
179_Q	241_Q	0.985	0.90
64_L	106_C	0.984	0.90
244_I	247_G	0.980	0.90
317_Q	360_Q	0.979	0.90
167_W	189_A	0.978	0.90
175_R	181_N	0.976	0.89
342_E	349_A	0.975	0.89
309_R	357_S	0.974	0.89
46_L	86_T	0.973	0.89
347_L	351_S	0.969	0.89
23_V	30_I	0.967	0.89
165_V	264_V	0.966	0.89
13_L	40_V	0.966	0.89
132_D	151_G	0.965	0.89
138_D	159_S	0.960	0.89
218_L	405_T	0.958	0.89
126_H	152_A	0.958	0.89
382_R	395_K	0.954	0.88
37_K	145_E	0.953	0.88
450_T	455_H	0.951	0.88
363_E	373_A	0.948	0.88
329_R	444_D	0.946	0.88
80_R	299_M	0.945	0.88
413_L	416_Q	0.944	0.88
19_H	296_V	0.942	0.88
61_W	96_F	0.941	0.88
37_K	41_R	0.937	0.87
201_R	280_N	0.936	0.87
452_Q	459_T	0.932	0.87
338_F	345_W	0.931	0.87
481_S	485_S	0.931	0.87
326_Q	330_V	0.930	0.87
145_E	213_G	0.929	0.87
143_S	159_S	0.927	0.87
16_N	116_E	0.927	0.87
427_L	430_L	0.926	0.87
336_N	340_Q	0.925	0.87
138_D	141_G	0.923	0.87
16_N	145_E	0.922	0.87
149_G	212_S	0.922	0.87
113_G	140_G	0.919	0.86
374_P	404_Q	0.915	0.86
85_A	142_A	0.915	0.86
248_R	262_A	0.909	0.86
17_S	145_E	0.901	0.85
11_I	103_I	0.900	0.85
141_G	261_R	0.899	0.85
119_L	298_G	0.899	0.85
68_A	106_C	0.899	0.85
59_R	63_C	0.897	0.85
88_R	145_E	0.897	0.85
336_N	448_E	0.893	0.85
57_M	99_K	0.893	0.85
87_L	110_V	0.892	0.85
83_A	408_V	0.891	0.85
273_I	277_T	0.887	0.84
354_L	424_A	0.884	0.84
317_Q	327_A	0.883	0.84
11_I	81_V	0.876	0.84
218_L	269_L	0.871	0.83
116_E	213_G	0.869	0.83
17_S	268_G	0.869	0.83
226_G	235_K	0.869	0.83
81_V	108_V	0.865	0.83
212_S	216_Q	0.865	0.83
117_A	139_I	0.865	0.83
117_A	157_L	0.863	0.83
287_A	293_E	0.862	0.83
7_L	33_L	0.862	0.83
138_D	145_E	0.860	0.83
350_I	353_D	0.857	0.82
247_G	251_E	0.855	0.82
124_V	398_A	0.854	0.82
352_R	356_I	0.852	0.82
56_A	59_R	0.850	0.82
82_V	111_I	0.850	0.82
138_D	213_G	0.849	0.82
375_Q	404_Q	0.843	0.81
330_V	434_A	0.842	0.81
117_A	261_R	0.841	0.81
42_L	309_R	0.841	0.81
234_E	280_N	0.841	0.81
43_A	166_T	0.840	0.81
81_V	103_I	0.840	0.81
302_L	305_E	0.837	0.81
262_A	266_P	0.837	0.81
378_A	395_K	0.837	0.81
12_D	140_G	0.836	0.81
233_L	284_M	0.834	0.81
162_M	271_I	0.833	0.81
12_D	145_E	0.831	0.80
320_F	367_S	0.831	0.80
227_M	238_Q	0.831	0.80
131_A	241_Q	0.830	0.80
124_V	136_V	0.829	0.80
350_I	393_Q	0.827	0.80
174_D	181_N	0.825	0.80
402_L	409_D	0.821	0.80
141_G	294_G	0.820	0.79
116_E	261_R	0.820	0.79
17_S	214_T	0.819	0.79
11_I	68_A	0.818	0.79
276_F	281_I	0.815	0.79
165_V	268_G	0.815	0.79
181_N	184_A	0.814	0.79
435_I	480_E	0.810	0.79
312_T	386_L	0.810	0.79
186_E	273_I	0.807	0.78
452_Q	456_E	0.806	0.78
355_L	431_L	0.806	0.78
37_K	113_G	0.803	0.78
368_V	376_H	0.802	0.78
41_R	165_V	0.801	0.78
31_Q	315_N	0.798	0.78
120_I	211_A	0.797	0.78
60_G	100_A	0.797	0.78
257_L	276_F	0.796	0.77
212_S	309_R	0.796	0.77
150_T	155_T	0.794	0.77
19_H	213_G	0.790	0.77
399_T	413_L	0.788	0.77
186_E	240_K	0.787	0.77
88_R	142_A	0.786	0.77
12_D	141_G	0.786	0.77
123_G	289_G	0.786	0.77
176_N	180_E	0.785	0.76
287_A	364_I	0.785	0.76
62_Q	193_L	0.784	0.76
322_I	327_A	0.784	0.76
23_V	293_E	0.783	0.76
50_N	89_L	0.782	0.76
218_L	272_L	0.782	0.76
117_A	140_G	0.781	0.76
22_V	353_D	0.781	0.76
236_L	276_F	0.781	0.76
344_E	348_E	0.780	0.76
334_A	355_L	0.779	0.76
365_G	377_A	0.779	0.76
12_D	84_T	0.778	0.76
218_L	236_L	0.778	0.76
117_A	143_S	0.777	0.76
45_G	60_G	0.777	0.76
117_A	214_T	0.777	0.76
314_R	324_I	0.775	0.76
12_D	15_S	0.775	0.76
453_A	457_L	0.772	0.75
269_L	273_I	0.771	0.75
25_E	30_I	0.770	0.75
11_I	381_V	0.770	0.75
20_M	35_R	0.769	0.75
276_F	279_L	0.769	0.75
140_G	261_R	0.768	0.75
102_E	346_H	0.766	0.75
320_F	384_L	0.766	0.75
378_A	398_A	0.764	0.75
74_I	79_I	0.764	0.75
482_Q	485_S	0.762	0.74
141_G	145_E	0.761	0.74
12_D	292_R	0.760	0.74
9_A	14_G	0.759	0.74
24_R	33_L	0.758	0.74
345_W	351_S	0.756	0.74
462_L	465_G	0.756	0.74
216_Q	290_A	0.755	0.74
113_G	214_T	0.755	0.74
116_E	138_D	0.754	0.74
261_R	290_A	0.754	0.74
118_R	144_T	0.753	0.73
312_T	387_P	0.753	0.73
71_L	166_T	0.752	0.73
115_E	298_G	0.751	0.73
50_N	81_V	0.750	0.73
329_R	333_V	0.749	0.73
314_R	318_R	0.748	0.73
13_L	20_M	0.748	0.73
140_G	145_E	0.747	0.73
113_G	268_G	0.747	0.73
391_P	394_K	0.745	0.73
16_N	214_T	0.745	0.73
232_T	235_K	0.745	0.73
18_F	40_V	0.743	0.72
120_I	147_V	0.743	0.72
375_Q	402_L	0.742	0.72
222_M	239_L	0.739	0.72
16_N	292_R	0.739	0.72
13_L	46_L	0.739	0.72
38_R	63_C	0.738	0.72
246_C	251_E	0.737	0.72
93_A	97_I	0.737	0.72
20_M	71_L	0.737	0.72
189_A	274_A	0.733	0.71
374_P	406_N	0.733	0.71
61_W	104_L	0.732	0.71
116_E	145_E	0.731	0.71
141_G	159_S	0.731	0.71
193_L	278_E	0.730	0.71
483_W	486_Y	0.728	0.71
88_R	138_D	0.727	0.71
42_L	86_T	0.726	0.71
246_C	252_L	0.726	0.71
141_G	292_R	0.724	0.70
335_A	343_N	0.723	0.70
355_L	427_L	0.722	0.70
438_A	444_D	0.722	0.70
377_A	400_L	0.720	0.70
95_D	99_K	0.718	0.70
81_V	104_L	0.718	0.70
117_A	141_G	0.718	0.70
182_F	189_A	0.717	0.70
326_Q	441_R	0.716	0.70
113_G	141_G	0.715	0.70
54_N	61_W	0.715	0.70
478_A	481_S	0.714	0.69
172_F	309_R	0.713	0.69
32_T	35_R	0.712	0.69
84_T	116_E	0.712	0.69
16_N	37_K	0.711	0.69
137_V	272_L	0.711	0.69
53_S	57_M	0.710	0.69
16_N	123_G	0.707	0.69
158_F	196_V	0.706	0.69
51_A	95_D	0.705	0.68
354_L	393_Q	0.705	0.68
145_E	292_R	0.704	0.68
396_L	423_V	0.703	0.68
120_I	145_E	0.703	0.68
386_L	390_T	0.701	0.68
262_A	401_L	0.701	0.68
328_Q	332_K	0.700	0.68
288_G	371_K	0.699	0.68
148_T	203_H	0.699	0.68
472_L	480_E	0.699	0.68
248_R	251_E	0.699	0.68
216_Q	371_K	0.698	0.68
280_N	459_T	0.698	0.68
214_T	261_R	0.696	0.67
117_A	213_G	0.694	0.67
135_L	362_H	0.693	0.67
301_H	305_E	0.693	0.67
12_D	117_A	0.691	0.67
182_F	273_I	0.691	0.67
55_E	450_T	0.687	0.66
43_A	89_L	0.687	0.66
53_S	67_F	0.686	0.66
248_R	252_L	0.685	0.66
123_G	297_Y	0.685	0.66
377_A	404_Q	0.685	0.66
282_Q	343_N	0.685	0.66
385_D	389_F	0.684	0.66
452_Q	455_H	0.682	0.66
37_K	138_D	0.682	0.66
92_N	142_A	0.680	0.66
87_L	93_A	0.677	0.65
16_N	117_A	0.677	0.65
216_Q	395_K	0.677	0.65
314_R	328_Q	0.677	0.65
12_D	17_S	0.676	0.65
19_H	35_R	0.675	0.65
337_F	460_L	0.674	0.65
137_V	220_E	0.674	0.65
479_Q	483_W	0.672	0.65
336_N	449_M	0.672	0.65
201_R	452_Q	0.671	0.65
113_G	138_D	0.667	0.64
364_I	380_L	0.666	0.64
408_V	429_R	0.666	0.64
17_S	113_G	0.664	0.64
137_V	215_V	0.663	0.64
97_I	103_I	0.661	0.63
330_V	431_L	0.661	0.63
135_L	205_W	0.660	0.63
120_I	268_G	0.659	0.63
162_M	193_L	0.659	0.63
83_A	218_L	0.658	0.63
243_A	252_L	0.657	0.63
115_E	119_L	0.657	0.63
356_I	360_Q	0.656	0.63
390_T	446_V	0.656	0.63
65_R	102_E	0.650	0.62
116_E	141_G	0.647	0.62
297_Y	307_D	0.646	0.62
320_F	368_V	0.646	0.62
113_G	143_S	0.645	0.62
317_Q	324_I	0.645	0.62
140_G	268_G	0.645	0.62
112_S	194_R	0.644	0.61
11_I	283_C	0.643	0.61
233_L	276_F	0.641	0.61
139_I	144_T	0.641	0.61
341_V	451_L	0.640	0.61
56_A	67_F	0.640	0.61
20_M	34_T	0.639	0.61
162_M	167_W	0.638	0.61
84_T	159_S	0.637	0.61
9_A	434_A	0.636	0.61
19_H	216_Q	0.636	0.61
68_A	103_I	0.635	0.60
126_H	387_P	0.635	0.60
359_C	434_A	0.635	0.60
209_V	479_Q	0.635	0.60
20_M	70_R	0.635	0.60
40_V	59_R	0.634	0.60
85_A	402_L	0.634	0.60
136_V	147_V	0.631	0.60
144_T	271_I	0.630	0.60
446_V	463_P	0.628	0.60
53_S	245_H	0.626	0.59
103_I	106_C	0.626	0.59
375_Q	412_S	0.625	0.59
34_T	70_R	0.624	0.59
93_A	390_T	0.624	0.59
165_V	209_V	0.623	0.59
378_A	382_R	0.623	0.59
21_L	216_Q	0.623	0.59
320_F	334_A	0.622	0.59
12_D	88_R	0.620	0.59
17_S	60_G	0.619	0.58
34_T	286_L	0.617	0.58
86_T	138_D	0.617	0.58
45_G	56_A	0.617	0.58
472_L	475_E	0.616	0.58
274_A	277_T	0.616	0.58
114_E	192_V	0.613	0.58
108_V	487_V	0.613	0.58
21_L	35_R	0.612	0.58
156_S	204_G	0.611	0.57
330_V	404_Q	0.611	0.57
342_E	454_N	0.611	0.57
16_N	138_D	0.611	0.57
240_K	273_I	0.610	0.57
141_G	213_G	0.610	0.57
18_F	212_S	0.610	0.57
66_L	370_F	0.609	0.57
108_V	239_L	0.609	0.57
373_A	435_I	0.609	0.57
332_K	336_N	0.608	0.57
71_L	106_C	0.606	0.57
222_M	231_I	0.606	0.57
234_E	332_K	0.605	0.57
37_K	312_T	0.605	0.57
339_D	342_E	0.605	0.57
129_G	244_I	0.604	0.57
146_L	196_V	0.603	0.56
188_A	192_V	0.602	0.56
222_M	228_D	0.602	0.56
360_Q	364_I	0.601	0.56
140_G	159_S	0.601	0.56
353_D	393_Q	0.600	0.56
270_A	274_A	0.597	0.56
232_T	448_E	0.597	0.56
476_I	479_Q	0.597	0.56
11_I	24_R	0.597	0.56
120_I	141_G	0.596	0.56
88_R	261_R	0.596	0.56
243_A	246_C	0.595	0.55
146_L	305_E	0.593	0.55
16_N	159_S	0.592	0.55
334_A	427_L	0.592	0.55
40_V	60_G	0.591	0.55
151_G	257_L	0.591	0.55
409_D	413_L	0.590	0.55
396_L	420_P	0.590	0.55
323_D	374_P	0.589	0.55
176_N	485_S	0.588	0.55
111_I	119_L	0.588	0.55
185_A	188_A	0.588	0.55
277_T	448_E	0.587	0.54
236_L	273_I	0.587	0.54
114_E	158_F	0.586	0.54
226_G	238_Q	0.585	0.54
88_R	143_S	0.584	0.54
448_E	463_P	0.583	0.54
189_A	193_L	0.582	0.54
305_E	342_E	0.580	0.54
19_H	293_E	0.580	0.54
123_G	214_T	0.580	0.54
469_Q	485_S	0.579	0.53
324_I	328_Q	0.579	0.53
113_G	116_E	0.579	0.53
199_E	202_Y	0.579	0.53
10_A	212_S	0.578	0.53
452_Q	457_L	0.578	0.53
12_D	261_R	0.578	0.53
57_M	61_W	0.578	0.53
55_E	97_I	0.577	0.53
413_L	419_V	0.577	0.53
459_T	469_Q	0.576	0.53
326_Q	363_E	0.576	0.53
330_V	362_H	0.576	0.53
321_M	367_S	0.574	0.53
483_W	487_V	0.574	0.53
326_Q	362_H	0.573	0.53
84_T	138_D	0.572	0.53
236_L	240_K	0.572	0.53
86_T	143_S	0.572	0.53
7_L	208_C	0.571	0.52
210_G	272_L	0.570	0.52
113_G	159_S	0.570	0.52
12_D	294_G	0.569	0.52
369_D	373_A	0.569	0.52
316_I	386_L	0.568	0.52
234_E	241_Q	0.568	0.52
358_A	397_L	0.568	0.52
317_Q	398_A	0.568	0.52
460_L	468_T	0.568	0.52
214_T	221_I	0.567	0.52
10_A	149_G	0.566	0.52
140_G	213_G	0.565	0.52
117_A	159_S	0.565	0.52
185_A	364_I	0.563	0.51
465_G	468_T	0.562	0.51
120_I	290_A	0.562	0.51
88_R	116_E	0.562	0.51
37_K	213_G	0.562	0.51
372_Q	375_Q	0.561	0.51
66_L	70_R	0.561	0.51
298_G	302_L	0.560	0.51
96_F	268_G	0.560	0.51
47_N	53_S	0.560	0.51
120_I	123_G	0.560	0.51
9_A	12_D	0.559	0.51
405_T	432_R	0.559	0.51
379_Y	383_N	0.558	0.51
407_P	411_S	0.557	0.51
267_S	271_I	0.557	0.51
215_V	284_M	0.554	0.50
376_H	431_L	0.554	0.50
130_G	209_V	0.553	0.50
86_T	90_A	0.553	0.50
83_A	301_H	0.552	0.50
288_G	370_F	0.550	0.50
12_D	291_L	0.550	0.50
336_N	461_T	0.549	0.50
246_C	254_I	0.547	0.49
284_M	388_G	0.547	0.49
241_Q	346_H	0.547	0.49
150_T	256_G	0.545	0.49
120_I	291_L	0.545	0.49
43_A	86_T	0.544	0.49
84_T	142_A	0.544	0.49
59_R	268_G	0.544	0.49
331_A	334_A	0.544	0.49
165_V	386_L	0.544	0.49
202_Y	277_T	0.541	0.49
191_E	462_L	0.541	0.49
83_A	110_V	0.539	0.48
104_L	147_V	0.539	0.48
331_A	359_C	0.538	0.48
219_Q	286_L	0.538	0.48
22_V	150_T	0.537	0.48
15_S	212_S	0.537	0.48
83_A	272_L	0.536	0.48
289_G	293_E	0.534	0.48
22_V	55_E	0.534	0.48
153_Q	234_E	0.534	0.48
234_E	253_E	0.532	0.48
44_A	320_F	0.532	0.48
194_R	278_E	0.531	0.47
113_G	272_L	0.531	0.47
159_S	213_G	0.531	0.47
238_Q	241_Q	0.531	0.47
209_V	285_T	0.530	0.47
219_Q	228_D	0.530	0.47
115_E	144_T	0.529	0.47
88_R	213_G	0.527	0.47
334_A	434_A	0.526	0.47
64_L	100_A	0.526	0.47
409_D	428_C	0.525	0.47
234_E	456_E	0.525	0.47
185_A	441_R	0.523	0.46
307_D	353_D	0.523	0.46
186_E	233_L	0.522	0.46
156_S	197_A	0.521	0.46
134_R	216_Q	0.521	0.46
23_V	32_T	0.519	0.46
267_S	380_L	0.517	0.46
145_E	261_R	0.516	0.46
110_V	440_R	0.516	0.46
66_L	432_R	0.512	0.45
221_I	239_L	0.510	0.45
37_K	167_W	0.508	0.45
119_L	363_E	0.507	0.44
104_L	107_P	0.507	0.44
46_L	100_A	0.507	0.44
29_S	54_N	0.507	0.44
19_H	41_R	0.505	0.44
455_H	459_T	0.505	0.44
359_C	431_L	0.505	0.44
406_N	438_A	0.505	0.44
165_V	267_S	0.504	0.44
450_T	457_L	0.504	0.44
393_Q	396_L	0.503	0.44
139_I	289_G	0.503	0.44
51_A	482_Q	0.502	0.44
84_T	291_L	0.502	0.44
13_L	60_G	0.502	0.44
122_Q	152_A	0.501	0.44
159_S	164_C	0.501	0.44
109_Q	123_G	0.501	0.44
85_A	89_L	0.501	0.44
101_Q	104_L	0.500	0.44

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1u6zA	2	0.9858	100	0.138	Contact Map
3hi0A	2	0.9636	100	0.215	Contact Map
3cerA	1	0.6174	100	0.483	Contact Map
1t6cA	1	0.5972	100	0.5	Contact Map
3mdqA	1	0.6113	100	0.5	Contact Map
4brcA	2	0.5992	100	0.653	Contact Map
3rf0A	1	0.3846	100	0.699	Contact Map
3cj1A	1	0.6478	100	0.748	Contact Map
3zx3A	3	0.6255	100	0.76	Contact Map
3h1qA	1	0.4696	99.7	0.867	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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