ASLB - ECOLI - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

ASLB - Anaerobic sulfatase-maturating enzyme homolog AslB

UniProt:	P25550	Sequences: MLQQVPTRAFHVMAKPSGSDCNLNCDYCFYLEKQSLYREKPVTHMDDDTLEAYVRHYIAASEPQNEVAFTWQGGEPTLLGLAFYRRAVALQAKYGAGRKISNSFQTNGVLLDDEWCAFLAEHHFLVGLSLDGPPEIHNQYRVTKGGRPTHKLVMRALTLLQKHHVDYNVLVCVNRTSAQQPLQVYDFLCDAGVEFIQFIPVVERLADETTARDGLKLHAPGDIQGELTEWSVRPEEFGEFLVAIFDHWIKRDVGKIFVMNIEWAFANFVGAPGAVCHHQPTCGRSVIVEHNGDVYACDHYVYPQYRLGNMHQQTIAEMIDSPQQQAFGEDKFKQLPAQCRSCNVLKACWGGCPKHRFMLDASGKPGLNYLCAGYQRYFRHLPPYLKAMADLLAHGRPASDIMHAHLLVVSK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10090
Length:	411 (335)
Sequences:	5425 (4254)
Seq/√Len:	232.4

ECOLI - ASLB YDEM MOAA
BACSU - ALBA SKFB MOAA YYDG
HALSA - Q9HQF5 MOAA Q9HQF7
SULSO - Q97XA7 Q97XS7 Q97XZ2 Q7LXV3 Q97XA6 Q97XS8 Q97WK5 Q97Y04 Q97WC3 MOAA Q980E0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
134_P	151_K	6.012	1.00
23_L	109_V	3.951	1.00
49_T	311_H	3.631	1.00
113_D	159_L	3.374	1.00
138_N	148_P	3.374	1.00
117_A	163_H	3.336	1.00
293_D	309_N	3.054	1.00
46_D	49_T	2.996	1.00
150_H	187_F	2.984	1.00
158_T	191_A	2.907	1.00
47_D	86_R	2.824	1.00
180_Q	183_Q	2.680	1.00
293_D	306_R	2.675	1.00
113_D	162_K	2.622	1.00
51_E	90_L	2.609	1.00
52_A	56_H	2.601	1.00
297_C	352_C	2.502	1.00
22_N	107_N	2.414	1.00
314_T	317_E	2.386	1.00
133_P	136_I	2.324	1.00
55_R	90_L	2.307	1.00
13_M	57_Y	2.273	1.00
85_R	118_F	2.248	1.00
108_G	128_L	2.162	1.00
113_D	163_H	2.160	1.00
79_L	83_F	2.149	1.00
309_N	312_Q	2.109	1.00
45_M	49_T	2.044	1.00
186_D	190_D	2.000	1.00
152_L	155_R	1.982	1.00
182_L	243_A	1.982	1.00
92_A	122_H	1.970	1.00
117_A	121_E	1.959	1.00
116_C	159_L	1.951	1.00
128_L	157_L	1.947	1.00
159_L	162_K	1.947	1.00
20_D	44_H	1.930	1.00
186_D	247_H	1.926	1.00
131_D	141_R	1.925	1.00
313_Q	317_E	1.916	1.00
175_R	236_E	1.911	1.00
118_F	122_H	1.907	1.00
279_Q	297_C	1.902	1.00
51_E	86_R	1.888	1.00
289_E	293_D	1.871	1.00
134_P	138_N	1.860	1.00
325_Q	328_G	1.822	1.00
112_D	115_W	1.822	1.00
139_Q	176_T	1.815	1.00
154_M	191_A	1.768	1.00
22_N	110_L	1.748	1.00
183_Q	186_D	1.746	1.00
158_T	162_K	1.711	1.00
137_H	149_T	1.692	1.00
44_H	79_L	1.688	1.00
111_L	116_C	1.687	1.00
86_R	89_A	1.634	1.00
158_T	161_Q	1.634	1.00
55_R	98_R	1.634	1.00
136_I	180_Q	1.634	1.00
317_E	321_S	1.632	1.00
133_P	180_Q	1.626	1.00
50_L	87_A	1.620	1.00
120_A	163_H	1.614	1.00
169_V	188_L	1.598	1.00
47_D	51_E	1.588	1.00
325_Q	329_E	1.587	1.00
279_Q	282_C	1.582	1.00
153_V	156_A	1.578	1.00
128_L	156_A	1.538	1.00
134_P	150_H	1.521	1.00
294_V	318_M	1.513	1.00
151_K	155_R	1.513	1.00
336_P	362_S	1.509	1.00
105_Q	127_G	1.501	1.00
71_W	102_N	1.489	1.00
85_R	121_E	1.484	1.00
276_C	279_Q	1.476	1.00
322_P	328_G	1.462	1.00
187_F	191_A	1.460	1.00
49_T	52_A	1.458	1.00
51_E	55_R	1.444	1.00
155_R	159_L	1.437	1.00
26_D	139_Q	1.431	1.00
126_V	160_L	1.427	1.00
242_V	246_D	1.382	1.00
279_Q	352_C	1.379	1.00
155_R	158_T	1.364	1.00
15_K	53_Y	1.335	1.00
56_H	314_T	1.316	1.00
322_P	325_Q	1.309	1.00
22_N	75_E	1.304	1.00
113_D	117_A	1.302	1.00
324_Q	327_F	1.296	1.00
154_M	187_F	1.296	1.00
130_L	169_V	1.296	1.00
137_H	148_P	1.292	1.00
88_V	118_F	1.281	1.00
77_T	104_F	1.265	1.00
169_V	193_V	1.264	1.00
140_Y	174_N	1.263	1.00
15_K	50_L	1.262	1.00
233_R	236_E	1.256	1.00
324_Q	328_G	1.252	1.00
118_F	121_E	1.248	1.00
77_T	110_L	1.239	1.00
185_Y	189_C	1.239	1.00
54_V	69_F	1.234	1.00
104_F	119_L	1.234	1.00
45_M	50_L	1.224	1.00
52_A	311_H	1.216	1.00
115_W	119_L	1.214	1.00
53_Y	288_V	1.212	1.00
289_E	295_Y	1.209	1.00
54_V	98_R	1.202	1.00
23_L	149_T	1.199	1.00
171_V	196_I	1.198	1.00
85_R	114_E	1.195	1.00
116_C	120_A	1.191	1.00
86_R	90_L	1.177	1.00
52_A	55_R	1.168	1.00
29_F	72_Q	1.168	1.00
26_D	140_Y	1.167	1.00
133_P	183_Q	1.161	1.00
295_Y	306_R	1.160	1.00
116_C	163_H	1.159	1.00
132_G	150_H	1.155	1.00
235_E	239_E	1.148	1.00
138_N	149_T	1.147	1.00
114_E	117_A	1.145	1.00
300_Y	354_K	1.141	1.00
91_Q	102_N	1.138	1.00
159_L	163_H	1.135	1.00
171_V	184_V	1.135	1.00
19_S	290_H	1.134	1.00
157_L	167_Y	1.134	1.00
43_T	291_N	1.130	1.00
161_Q	192_G	1.126	1.00
104_F	126_V	1.122	1.00
87_A	91_Q	1.113	1.00
85_R	89_A	1.105	1.00
132_G	136_I	1.098	1.00
57_Y	69_F	1.090	1.00
337_A	340_R	1.088	1.00
247_H	250_K	1.088	1.00
337_A	341_S	1.080	1.00
323_Q	327_F	1.078	1.00
88_V	124_F	1.075	1.00
239_E	243_A	1.074	1.00
17_S	71_W	1.073	1.00
116_C	156_A	1.072	1.00
109_V	156_A	1.065	1.00
182_L	247_H	1.053	1.00
238_G	242_V	1.050	1.00
156_A	159_L	1.049	1.00
27_Y	140_Y	1.044	1.00
243_A	247_H	1.044	1.00
77_T	156_A	1.043	1.00
152_L	156_A	1.040	1.00
294_V	315_I	1.039	1.00
160_L	165_V	1.031	1.00
338_Q	367_L	1.030	1.00
27_Y	131_D	1.027	1.00
239_E	242_V	1.022	1.00
236_E	239_E	1.022	1.00
83_F	87_A	1.020	1.00
85_R	115_W	1.010	1.00
132_G	141_R	1.007	1.00
120_A	164_H	1.001	1.00
47_D	83_F	0.997	1.00
188_L	193_V	0.994	1.00
154_M	158_T	0.992	1.00
18_G	44_H	0.984	1.00
89_A	118_F	0.976	1.00
68_A	101_S	0.972	1.00
322_P	326_A	0.967	1.00
88_V	122_H	0.967	1.00
246_D	249_I	0.965	1.00
339_C	348_C	0.963	1.00
129_S	172_C	0.958	1.00
338_Q	368_N	0.958	1.00
127_G	170_L	0.957	1.00
308_G	313_Q	0.956	1.00
16_P	72_Q	0.951	1.00
22_N	109_V	0.951	1.00
137_H	150_H	0.946	1.00
111_L	156_A	0.945	1.00
234_P	238_G	0.935	1.00
186_D	189_C	0.934	1.00
286_V	315_I	0.933	1.00
56_H	59_A	0.928	1.00
181_P	243_A	0.927	1.00
90_L	94_Y	0.926	1.00
353_P	356_R	0.926	1.00
55_R	59_A	0.921	1.00
89_A	122_H	0.918	1.00
313_Q	318_M	0.914	1.00
141_R	146_G	0.913	1.00
111_L	160_L	0.909	1.00
348_C	371_C	0.908	1.00
128_L	160_L	0.906	1.00
54_V	91_Q	0.904	1.00
323_Q	328_G	0.904	1.00
313_Q	321_S	0.903	1.00
243_A	246_D	0.902	0.99
79_L	86_R	0.902	0.99
75_E	107_N	0.895	0.99
77_T	115_W	0.893	0.99
150_H	154_M	0.892	0.99
179_Q	236_E	0.892	0.99
56_H	60_A	0.891	0.99
326_A	329_E	0.882	0.99
246_D	250_K	0.877	0.99
149_T	153_V	0.877	0.99
68_A	103_S	0.876	0.99
114_E	118_F	0.870	0.99
146_G	149_T	0.868	0.99
69_F	91_Q	0.867	0.99
308_G	318_M	0.866	0.99
305_Y	357_F	0.859	0.99
107_N	110_L	0.855	0.99
316_A	320_D	0.851	0.99
166_D	194_E	0.848	0.99
184_V	188_L	0.846	0.99
339_C	342_C	0.845	0.99
336_P	367_L	0.836	0.99
138_N	141_R	0.836	0.99
50_L	53_Y	0.835	0.99
110_L	156_A	0.831	0.99
13_M	286_V	0.829	0.99
22_N	78_L	0.828	0.99
69_F	102_N	0.826	0.99
21_C	28_C	0.822	0.99
105_Q	298_D	0.822	0.99
83_F	86_R	0.818	0.99
232_V	236_E	0.818	0.99
55_R	94_Y	0.817	0.99
322_P	327_F	0.816	0.99
115_W	118_F	0.814	0.99
137_H	153_V	0.811	0.99
105_Q	170_L	0.809	0.99
72_Q	105_Q	0.807	0.99
179_Q	239_E	0.805	0.99
171_V	188_L	0.805	0.99
111_L	115_W	0.805	0.99
72_Q	298_D	0.802	0.99
260_N	263_W	0.801	0.99
18_G	79_L	0.800	0.99
323_Q	326_A	0.799	0.99
339_C	371_C	0.798	0.99
157_L	169_V	0.798	0.99
17_S	79_L	0.795	0.99
178_A	236_E	0.795	0.99
314_T	318_M	0.794	0.99
56_H	316_A	0.791	0.99
245_F	249_I	0.791	0.99
255_K	259_M	0.789	0.99
79_L	87_A	0.787	0.99
58_I	98_R	0.786	0.99
66_E	101_S	0.785	0.99
135_E	139_Q	0.784	0.99
161_Q	167_Y	0.784	0.99
247_H	251_R	0.783	0.99
116_C	160_L	0.783	0.99
335_L	345_L	0.781	0.99
201_V	207_D	0.781	0.99
54_V	71_W	0.780	0.99
21_C	25_C	0.777	0.98
288_V	294_V	0.776	0.98
112_D	156_A	0.775	0.98
25_C	28_C	0.775	0.98
45_M	53_Y	0.773	0.98
119_L	124_F	0.772	0.98
157_L	193_V	0.772	0.98
151_K	154_M	0.771	0.98
321_S	324_Q	0.769	0.98
345_L	349_W	0.766	0.98
256_I	259_M	0.763	0.98
132_G	180_Q	0.762	0.98
113_D	116_C	0.757	0.98
327_F	330_D	0.755	0.98
17_S	50_L	0.753	0.98
50_L	54_V	0.750	0.98
49_T	53_Y	0.750	0.98
92_A	121_E	0.750	0.98
161_Q	194_E	0.745	0.98
255_K	258_V	0.745	0.98
14_A	285_S	0.743	0.98
134_P	148_P	0.743	0.98
174_N	177_S	0.743	0.98
16_P	287_I	0.743	0.98
75_E	106_T	0.740	0.98
303_P	306_R	0.739	0.98
111_L	119_L	0.735	0.98
170_L	298_D	0.733	0.98
59_A	316_A	0.732	0.98
116_C	126_V	0.731	0.98
60_A	315_I	0.730	0.98
50_L	90_L	0.726	0.98
189_C	251_R	0.725	0.98
27_Y	141_R	0.725	0.98
175_R	233_R	0.724	0.98
351_G	368_N	0.723	0.98
254_G	258_V	0.722	0.98
137_H	141_R	0.721	0.98
58_I	100_I	0.720	0.98
322_P	329_E	0.717	0.97
276_C	280_P	0.715	0.97
336_P	366_G	0.713	0.97
343_N	375_Q	0.712	0.97
126_V	165_V	0.709	0.97
117_A	120_A	0.709	0.97
16_P	170_L	0.707	0.97
342_C	348_C	0.705	0.97
138_N	146_G	0.704	0.97
361_A	364_K	0.694	0.97
92_A	102_N	0.693	0.97
135_E	183_Q	0.693	0.97
241_L	245_F	0.691	0.97
15_K	27_Y	0.688	0.97
169_V	196_I	0.688	0.97
170_L	199_I	0.686	0.97
32_E	206_A	0.686	0.97
323_Q	329_E	0.684	0.97
66_E	99_K	0.682	0.97
287_I	298_D	0.680	0.97
47_D	79_L	0.680	0.97
286_V	319_I	0.679	0.96
160_L	167_Y	0.677	0.96
84_Y	88_V	0.676	0.96
70_T	103_S	0.675	0.96
72_Q	127_G	0.674	0.96
132_G	137_H	0.673	0.96
306_R	309_N	0.672	0.96
181_P	240_F	0.672	0.96
338_Q	375_Q	0.669	0.96
79_L	84_Y	0.668	0.96
130_L	154_M	0.668	0.96
20_D	42_V	0.665	0.96
138_N	150_H	0.659	0.96
30_Y	172_C	0.659	0.96
332_F	335_L	0.658	0.96
245_F	248_W	0.655	0.96
91_Q	94_Y	0.654	0.96
58_I	94_Y	0.652	0.96
48_D	52_A	0.650	0.96
27_Y	172_C	0.650	0.96
187_F	190_D	0.645	0.95
70_T	105_Q	0.643	0.95
244_I	248_W	0.640	0.95
156_A	160_L	0.635	0.95
135_E	180_Q	0.634	0.95
294_V	313_Q	0.631	0.95
188_L	196_I	0.630	0.95
161_Q	193_V	0.630	0.95
102_N	124_F	0.629	0.95
88_V	102_N	0.625	0.94
317_E	320_D	0.623	0.94
263_W	267_N	0.623	0.94
161_Q	191_A	0.619	0.94
320_D	326_A	0.619	0.94
242_V	376_R	0.618	0.94
172_C	201_V	0.616	0.94
75_E	108_G	0.616	0.94
248_W	251_R	0.615	0.94
189_C	256_I	0.615	0.94
195_F	257_F	0.614	0.94
261_I	264_A	0.610	0.94
201_V	205_L	0.610	0.94
288_V	310_M	0.610	0.94
181_P	185_Y	0.610	0.94
342_C	371_C	0.607	0.94
14_A	70_T	0.606	0.94
157_L	191_A	0.605	0.93
57_Y	66_E	0.603	0.93
83_F	90_L	0.603	0.93
14_A	298_D	0.601	0.93
71_W	88_V	0.601	0.93
59_A	314_T	0.601	0.93
17_S	84_Y	0.600	0.93
185_Y	244_I	0.599	0.93
351_G	356_R	0.599	0.93
239_E	376_R	0.596	0.93
52_A	314_T	0.596	0.93
374_Y	378_F	0.595	0.93
97_G	100_I	0.595	0.93
319_I	328_G	0.591	0.93
181_P	198_F	0.590	0.93
96_A	125_L	0.590	0.93
16_P	172_C	0.588	0.92
344_V	375_Q	0.587	0.92
30_Y	298_D	0.587	0.92
119_L	165_V	0.584	0.92
360_D	366_G	0.583	0.92
127_G	168_N	0.583	0.92
92_A	123_H	0.582	0.92
14_A	72_Q	0.581	0.92
204_R	207_D	0.581	0.92
109_V	152_L	0.579	0.92
360_D	367_L	0.579	0.92
205_L	208_E	0.576	0.92
262_E	267_N	0.575	0.92
130_L	150_H	0.574	0.92
65_N	99_K	0.574	0.92
321_S	325_Q	0.574	0.92
281_T	297_C	0.573	0.92
88_V	91_Q	0.571	0.91
141_R	149_T	0.568	0.91
30_Y	287_I	0.568	0.91
130_L	153_V	0.566	0.91
120_A	165_V	0.566	0.91
16_P	105_Q	0.565	0.91
160_L	163_H	0.563	0.91
129_S	141_R	0.562	0.91
30_Y	72_Q	0.562	0.91
189_C	247_H	0.562	0.91
47_D	90_L	0.561	0.91
72_Q	170_L	0.561	0.91
173_V	240_F	0.561	0.91
324_Q	329_E	0.561	0.91
278_H	281_T	0.560	0.91
304_Q	357_F	0.558	0.90
176_T	230_W	0.558	0.90
16_P	290_H	0.557	0.90
244_I	247_H	0.557	0.90
344_V	347_A	0.556	0.90
15_K	45_M	0.556	0.90
315_I	319_I	0.555	0.90
16_P	19_S	0.554	0.90
71_W	91_Q	0.553	0.90
296_A	300_Y	0.550	0.90
126_V	378_F	0.550	0.90
278_H	282_C	0.548	0.90
296_A	307_L	0.545	0.89
18_G	290_H	0.545	0.89
231_S	237_F	0.544	0.89
127_G	298_D	0.543	0.89
182_L	246_D	0.542	0.89
24_N	146_G	0.542	0.89
119_L	160_L	0.539	0.89
60_A	316_A	0.538	0.89
260_N	266_A	0.536	0.89
264_A	267_N	0.535	0.89
173_V	198_F	0.535	0.89
116_C	165_V	0.534	0.88
50_L	79_L	0.533	0.88
52_A	313_Q	0.533	0.88
260_N	265_F	0.531	0.88
50_L	71_W	0.531	0.88
254_G	257_F	0.530	0.88
16_P	30_Y	0.530	0.88
167_Y	193_V	0.528	0.88
351_G	355_H	0.528	0.88
350_G	356_R	0.527	0.88
45_M	83_F	0.526	0.88
182_L	186_D	0.526	0.88
27_Y	30_Y	0.525	0.88
199_I	202_V	0.525	0.88
320_D	323_Q	0.524	0.87
368_N	374_Y	0.524	0.87
326_A	330_D	0.524	0.87
232_V	240_F	0.523	0.87
295_Y	308_G	0.522	0.87
105_Q	299_H	0.522	0.87
12_V	70_T	0.521	0.87
175_R	229_E	0.521	0.87
16_P	298_D	0.520	0.87
237_F	241_L	0.520	0.87
44_H	311_H	0.519	0.87
72_Q	199_I	0.519	0.87
27_Y	102_N	0.518	0.87
77_T	109_V	0.518	0.87
233_R	243_A	0.517	0.87
263_W	266_A	0.516	0.87
292_G	310_M	0.516	0.87
179_Q	243_A	0.515	0.87
85_R	90_L	0.514	0.86
172_C	199_I	0.514	0.86
240_F	248_W	0.514	0.86
285_S	298_D	0.513	0.86
51_E	94_Y	0.513	0.86
307_L	322_P	0.513	0.86
186_D	251_R	0.513	0.86
160_L	164_H	0.511	0.86
179_Q	182_L	0.511	0.86
10_F	319_I	0.509	0.86
311_H	314_T	0.509	0.86
229_E	233_R	0.509	0.86
119_L	122_H	0.507	0.86
141_R	172_C	0.506	0.86
20_D	78_L	0.505	0.86
78_L	152_L	0.505	0.86
254_G	259_M	0.505	0.86
108_G	157_L	0.504	0.85
132_G	138_N	0.504	0.85
106_T	128_L	0.504	0.85
134_P	187_F	0.503	0.85
53_Y	310_M	0.502	0.85
256_I	260_N	0.502	0.85
88_V	92_A	0.502	0.85
296_A	299_H	0.501	0.85
227_L	230_W	0.500	0.85

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4k36A	1	0.8954	100	0.293	Contact Map
1tv8A	2	0.7518	100	0.546	Contact Map
4m7tA	1	0.5815	100	0.557	Contact Map
4rtbA	2	0.8127	100	0.619	Contact Map
4wcxA	1	0.8881	100	0.633	Contact Map
3c8fA	1	0.5499	100	0.664	Contact Map
2yx0A	1	0.6107	99.9	0.695	Contact Map
2qgqA	1	0.6083	99.9	0.699	Contact Map
2z2uA	1	0.528	99.9	0.708	Contact Map
3rfaA	1	0.5985	99.9	0.713	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.054 seconds.