GREMLIN Database
ASLB - Anaerobic sulfatase-maturating enzyme homolog AslB
UniProt: P25550 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10090
Length: 411 (335)
Sequences: 5425 (4254)
Seq/√Len: 232.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
134_P151_K6.0121.00
23_L109_V3.9511.00
49_T311_H3.6311.00
113_D159_L3.3741.00
138_N148_P3.3741.00
117_A163_H3.3361.00
293_D309_N3.0541.00
46_D49_T2.9961.00
150_H187_F2.9841.00
158_T191_A2.9071.00
47_D86_R2.8241.00
180_Q183_Q2.6801.00
293_D306_R2.6751.00
113_D162_K2.6221.00
51_E90_L2.6091.00
52_A56_H2.6011.00
297_C352_C2.5021.00
22_N107_N2.4141.00
314_T317_E2.3861.00
133_P136_I2.3241.00
55_R90_L2.3071.00
13_M57_Y2.2731.00
85_R118_F2.2481.00
108_G128_L2.1621.00
113_D163_H2.1601.00
79_L83_F2.1491.00
309_N312_Q2.1091.00
45_M49_T2.0441.00
186_D190_D2.0001.00
152_L155_R1.9821.00
182_L243_A1.9821.00
92_A122_H1.9701.00
117_A121_E1.9591.00
116_C159_L1.9511.00
128_L157_L1.9471.00
159_L162_K1.9471.00
20_D44_H1.9301.00
186_D247_H1.9261.00
131_D141_R1.9251.00
313_Q317_E1.9161.00
175_R236_E1.9111.00
118_F122_H1.9071.00
279_Q297_C1.9021.00
51_E86_R1.8881.00
289_E293_D1.8711.00
134_P138_N1.8601.00
325_Q328_G1.8221.00
112_D115_W1.8221.00
139_Q176_T1.8151.00
154_M191_A1.7681.00
22_N110_L1.7481.00
183_Q186_D1.7461.00
158_T162_K1.7111.00
137_H149_T1.6921.00
44_H79_L1.6881.00
111_L116_C1.6871.00
86_R89_A1.6341.00
158_T161_Q1.6341.00
55_R98_R1.6341.00
136_I180_Q1.6341.00
317_E321_S1.6321.00
133_P180_Q1.6261.00
50_L87_A1.6201.00
120_A163_H1.6141.00
169_V188_L1.5981.00
47_D51_E1.5881.00
325_Q329_E1.5871.00
279_Q282_C1.5821.00
153_V156_A1.5781.00
128_L156_A1.5381.00
134_P150_H1.5211.00
294_V318_M1.5131.00
151_K155_R1.5131.00
336_P362_S1.5091.00
105_Q127_G1.5011.00
71_W102_N1.4891.00
85_R121_E1.4841.00
276_C279_Q1.4761.00
322_P328_G1.4621.00
187_F191_A1.4601.00
49_T52_A1.4581.00
51_E55_R1.4441.00
155_R159_L1.4371.00
26_D139_Q1.4311.00
126_V160_L1.4271.00
242_V246_D1.3821.00
279_Q352_C1.3791.00
155_R158_T1.3641.00
15_K53_Y1.3351.00
56_H314_T1.3161.00
322_P325_Q1.3091.00
22_N75_E1.3041.00
113_D117_A1.3021.00
324_Q327_F1.2961.00
154_M187_F1.2961.00
130_L169_V1.2961.00
137_H148_P1.2921.00
88_V118_F1.2811.00
77_T104_F1.2651.00
169_V193_V1.2641.00
140_Y174_N1.2631.00
15_K50_L1.2621.00
233_R236_E1.2561.00
324_Q328_G1.2521.00
118_F121_E1.2481.00
77_T110_L1.2391.00
185_Y189_C1.2391.00
54_V69_F1.2341.00
104_F119_L1.2341.00
45_M50_L1.2241.00
52_A311_H1.2161.00
115_W119_L1.2141.00
53_Y288_V1.2121.00
289_E295_Y1.2091.00
54_V98_R1.2021.00
23_L149_T1.1991.00
171_V196_I1.1981.00
85_R114_E1.1951.00
116_C120_A1.1911.00
86_R90_L1.1771.00
52_A55_R1.1681.00
29_F72_Q1.1681.00
26_D140_Y1.1671.00
133_P183_Q1.1611.00
295_Y306_R1.1601.00
116_C163_H1.1591.00
132_G150_H1.1551.00
235_E239_E1.1481.00
138_N149_T1.1471.00
114_E117_A1.1451.00
300_Y354_K1.1411.00
91_Q102_N1.1381.00
159_L163_H1.1351.00
171_V184_V1.1351.00
19_S290_H1.1341.00
157_L167_Y1.1341.00
43_T291_N1.1301.00
161_Q192_G1.1261.00
104_F126_V1.1221.00
87_A91_Q1.1131.00
85_R89_A1.1051.00
132_G136_I1.0981.00
57_Y69_F1.0901.00
337_A340_R1.0881.00
247_H250_K1.0881.00
337_A341_S1.0801.00
323_Q327_F1.0781.00
88_V124_F1.0751.00
239_E243_A1.0741.00
17_S71_W1.0731.00
116_C156_A1.0721.00
109_V156_A1.0651.00
182_L247_H1.0531.00
238_G242_V1.0501.00
156_A159_L1.0491.00
27_Y140_Y1.0441.00
243_A247_H1.0441.00
77_T156_A1.0431.00
152_L156_A1.0401.00
294_V315_I1.0391.00
160_L165_V1.0311.00
338_Q367_L1.0301.00
27_Y131_D1.0271.00
239_E242_V1.0221.00
236_E239_E1.0221.00
83_F87_A1.0201.00
85_R115_W1.0101.00
132_G141_R1.0071.00
120_A164_H1.0011.00
47_D83_F0.9971.00
188_L193_V0.9941.00
154_M158_T0.9921.00
18_G44_H0.9841.00
89_A118_F0.9761.00
68_A101_S0.9721.00
322_P326_A0.9671.00
88_V122_H0.9671.00
246_D249_I0.9651.00
339_C348_C0.9631.00
129_S172_C0.9581.00
338_Q368_N0.9581.00
127_G170_L0.9571.00
308_G313_Q0.9561.00
16_P72_Q0.9511.00
22_N109_V0.9511.00
137_H150_H0.9461.00
111_L156_A0.9451.00
234_P238_G0.9351.00
186_D189_C0.9341.00
286_V315_I0.9331.00
56_H59_A0.9281.00
181_P243_A0.9271.00
90_L94_Y0.9261.00
353_P356_R0.9261.00
55_R59_A0.9211.00
89_A122_H0.9181.00
313_Q318_M0.9141.00
141_R146_G0.9131.00
111_L160_L0.9091.00
348_C371_C0.9081.00
128_L160_L0.9061.00
54_V91_Q0.9041.00
323_Q328_G0.9041.00
313_Q321_S0.9031.00
243_A246_D0.9020.99
79_L86_R0.9020.99
75_E107_N0.8950.99
77_T115_W0.8930.99
150_H154_M0.8920.99
179_Q236_E0.8920.99
56_H60_A0.8910.99
326_A329_E0.8820.99
246_D250_K0.8770.99
149_T153_V0.8770.99
68_A103_S0.8760.99
114_E118_F0.8700.99
146_G149_T0.8680.99
69_F91_Q0.8670.99
308_G318_M0.8660.99
305_Y357_F0.8590.99
107_N110_L0.8550.99
316_A320_D0.8510.99
166_D194_E0.8480.99
184_V188_L0.8460.99
339_C342_C0.8450.99
336_P367_L0.8360.99
138_N141_R0.8360.99
50_L53_Y0.8350.99
110_L156_A0.8310.99
13_M286_V0.8290.99
22_N78_L0.8280.99
69_F102_N0.8260.99
21_C28_C0.8220.99
105_Q298_D0.8220.99
83_F86_R0.8180.99
232_V236_E0.8180.99
55_R94_Y0.8170.99
322_P327_F0.8160.99
115_W118_F0.8140.99
137_H153_V0.8110.99
105_Q170_L0.8090.99
72_Q105_Q0.8070.99
179_Q239_E0.8050.99
171_V188_L0.8050.99
111_L115_W0.8050.99
72_Q298_D0.8020.99
260_N263_W0.8010.99
18_G79_L0.8000.99
323_Q326_A0.7990.99
339_C371_C0.7980.99
157_L169_V0.7980.99
17_S79_L0.7950.99
178_A236_E0.7950.99
314_T318_M0.7940.99
56_H316_A0.7910.99
245_F249_I0.7910.99
255_K259_M0.7890.99
79_L87_A0.7870.99
58_I98_R0.7860.99
66_E101_S0.7850.99
135_E139_Q0.7840.99
161_Q167_Y0.7840.99
247_H251_R0.7830.99
116_C160_L0.7830.99
335_L345_L0.7810.99
201_V207_D0.7810.99
54_V71_W0.7800.99
21_C25_C0.7770.98
288_V294_V0.7760.98
112_D156_A0.7750.98
25_C28_C0.7750.98
45_M53_Y0.7730.98
119_L124_F0.7720.98
157_L193_V0.7720.98
151_K154_M0.7710.98
321_S324_Q0.7690.98
345_L349_W0.7660.98
256_I259_M0.7630.98
132_G180_Q0.7620.98
113_D116_C0.7570.98
327_F330_D0.7550.98
17_S50_L0.7530.98
50_L54_V0.7500.98
49_T53_Y0.7500.98
92_A121_E0.7500.98
161_Q194_E0.7450.98
255_K258_V0.7450.98
14_A285_S0.7430.98
134_P148_P0.7430.98
174_N177_S0.7430.98
16_P287_I0.7430.98
75_E106_T0.7400.98
303_P306_R0.7390.98
111_L119_L0.7350.98
170_L298_D0.7330.98
59_A316_A0.7320.98
116_C126_V0.7310.98
60_A315_I0.7300.98
50_L90_L0.7260.98
189_C251_R0.7250.98
27_Y141_R0.7250.98
175_R233_R0.7240.98
351_G368_N0.7230.98
254_G258_V0.7220.98
137_H141_R0.7210.98
58_I100_I0.7200.98
322_P329_E0.7170.97
276_C280_P0.7150.97
336_P366_G0.7130.97
343_N375_Q0.7120.97
126_V165_V0.7090.97
117_A120_A0.7090.97
16_P170_L0.7070.97
342_C348_C0.7050.97
138_N146_G0.7040.97
361_A364_K0.6940.97
92_A102_N0.6930.97
135_E183_Q0.6930.97
241_L245_F0.6910.97
15_K27_Y0.6880.97
169_V196_I0.6880.97
170_L199_I0.6860.97
32_E206_A0.6860.97
323_Q329_E0.6840.97
66_E99_K0.6820.97
287_I298_D0.6800.97
47_D79_L0.6800.97
286_V319_I0.6790.96
160_L167_Y0.6770.96
84_Y88_V0.6760.96
70_T103_S0.6750.96
72_Q127_G0.6740.96
132_G137_H0.6730.96
306_R309_N0.6720.96
181_P240_F0.6720.96
338_Q375_Q0.6690.96
79_L84_Y0.6680.96
130_L154_M0.6680.96
20_D42_V0.6650.96
138_N150_H0.6590.96
30_Y172_C0.6590.96
332_F335_L0.6580.96
245_F248_W0.6550.96
91_Q94_Y0.6540.96
58_I94_Y0.6520.96
48_D52_A0.6500.96
27_Y172_C0.6500.96
187_F190_D0.6450.95
70_T105_Q0.6430.95
244_I248_W0.6400.95
156_A160_L0.6350.95
135_E180_Q0.6340.95
294_V313_Q0.6310.95
188_L196_I0.6300.95
161_Q193_V0.6300.95
102_N124_F0.6290.95
88_V102_N0.6250.94
317_E320_D0.6230.94
263_W267_N0.6230.94
161_Q191_A0.6190.94
320_D326_A0.6190.94
242_V376_R0.6180.94
172_C201_V0.6160.94
75_E108_G0.6160.94
248_W251_R0.6150.94
189_C256_I0.6150.94
195_F257_F0.6140.94
261_I264_A0.6100.94
201_V205_L0.6100.94
288_V310_M0.6100.94
181_P185_Y0.6100.94
342_C371_C0.6070.94
14_A70_T0.6060.94
157_L191_A0.6050.93
57_Y66_E0.6030.93
83_F90_L0.6030.93
14_A298_D0.6010.93
71_W88_V0.6010.93
59_A314_T0.6010.93
17_S84_Y0.6000.93
185_Y244_I0.5990.93
351_G356_R0.5990.93
239_E376_R0.5960.93
52_A314_T0.5960.93
374_Y378_F0.5950.93
97_G100_I0.5950.93
319_I328_G0.5910.93
181_P198_F0.5900.93
96_A125_L0.5900.93
16_P172_C0.5880.92
344_V375_Q0.5870.92
30_Y298_D0.5870.92
119_L165_V0.5840.92
360_D366_G0.5830.92
127_G168_N0.5830.92
92_A123_H0.5820.92
14_A72_Q0.5810.92
204_R207_D0.5810.92
109_V152_L0.5790.92
360_D367_L0.5790.92
205_L208_E0.5760.92
262_E267_N0.5750.92
130_L150_H0.5740.92
65_N99_K0.5740.92
321_S325_Q0.5740.92
281_T297_C0.5730.92
88_V91_Q0.5710.91
141_R149_T0.5680.91
30_Y287_I0.5680.91
130_L153_V0.5660.91
120_A165_V0.5660.91
16_P105_Q0.5650.91
160_L163_H0.5630.91
129_S141_R0.5620.91
30_Y72_Q0.5620.91
189_C247_H0.5620.91
47_D90_L0.5610.91
72_Q170_L0.5610.91
173_V240_F0.5610.91
324_Q329_E0.5610.91
278_H281_T0.5600.91
304_Q357_F0.5580.90
176_T230_W0.5580.90
16_P290_H0.5570.90
244_I247_H0.5570.90
344_V347_A0.5560.90
15_K45_M0.5560.90
315_I319_I0.5550.90
16_P19_S0.5540.90
71_W91_Q0.5530.90
296_A300_Y0.5500.90
126_V378_F0.5500.90
278_H282_C0.5480.90
296_A307_L0.5450.89
18_G290_H0.5450.89
231_S237_F0.5440.89
127_G298_D0.5430.89
182_L246_D0.5420.89
24_N146_G0.5420.89
119_L160_L0.5390.89
60_A316_A0.5380.89
260_N266_A0.5360.89
264_A267_N0.5350.89
173_V198_F0.5350.89
116_C165_V0.5340.88
50_L79_L0.5330.88
52_A313_Q0.5330.88
260_N265_F0.5310.88
50_L71_W0.5310.88
254_G257_F0.5300.88
16_P30_Y0.5300.88
167_Y193_V0.5280.88
351_G355_H0.5280.88
350_G356_R0.5270.88
45_M83_F0.5260.88
182_L186_D0.5260.88
27_Y30_Y0.5250.88
199_I202_V0.5250.88
320_D323_Q0.5240.87
368_N374_Y0.5240.87
326_A330_D0.5240.87
232_V240_F0.5230.87
295_Y308_G0.5220.87
105_Q299_H0.5220.87
12_V70_T0.5210.87
175_R229_E0.5210.87
16_P298_D0.5200.87
237_F241_L0.5200.87
44_H311_H0.5190.87
72_Q199_I0.5190.87
27_Y102_N0.5180.87
77_T109_V0.5180.87
233_R243_A0.5170.87
263_W266_A0.5160.87
292_G310_M0.5160.87
179_Q243_A0.5150.87
85_R90_L0.5140.86
172_C199_I0.5140.86
240_F248_W0.5140.86
285_S298_D0.5130.86
51_E94_Y0.5130.86
307_L322_P0.5130.86
186_D251_R0.5130.86
160_L164_H0.5110.86
179_Q182_L0.5110.86
10_F319_I0.5090.86
311_H314_T0.5090.86
229_E233_R0.5090.86
119_L122_H0.5070.86
141_R172_C0.5060.86
20_D78_L0.5050.86
78_L152_L0.5050.86
254_G259_M0.5050.86
108_G157_L0.5040.85
132_G138_N0.5040.85
106_T128_L0.5040.85
134_P187_F0.5030.85
53_Y310_M0.5020.85
256_I260_N0.5020.85
88_V92_A0.5020.85
296_A299_H0.5010.85
227_L230_W0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4k36A 1 0.8954 100 0.293 Contact Map
1tv8A 2 0.7518 100 0.546 Contact Map
4m7tA 1 0.5815 100 0.557 Contact Map
4rtbA 2 0.8127 100 0.619 Contact Map
4wcxA 1 0.8881 100 0.633 Contact Map
3c8fA 1 0.5499 100 0.664 Contact Map
2yx0A 1 0.6107 99.9 0.695 Contact Map
2qgqA 1 0.6083 99.9 0.699 Contact Map
2z2uA 1 0.528 99.9 0.708 Contact Map
3rfaA 1 0.5985 99.9 0.713 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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