ASLA - ECOLI - GREMLIN Contacts

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ASLA - Arylsulfatase

UniProt:	P25549	Sequences: MEFSFSPKRLVVAVAAALPLMASAADTPSTATARKGFAGYDHPNQYLVKPATTIADNMMPVMQHPAQDKETQQKLAELEKKTGKKPNVVVFLLDDVGWMDVGFNGGGVAVGNPTPDIDAVASQGLILTSAYSQPSSSPTRATILTGQYSIHHGILMPPMYGQPGGLQGLTTLPQLLHDQGYVTQAIGKWHMGENKESQPQNVGFDDFRGFNSVSDMYTEWRDVHVNPEVALSPDRSEYIKQLPFSKDDVHAVRGGEQQAIADITPKYMEDLDQRWMDYGVKFLDKMAKSDKPFFLYYGTRGCHFDNYPNAKYAGSSPARTSYGDCMVEMNDVFANLYKTLEKNGQLDNTLIVFTSDNGPEAEVPPHGRTPFRGAKGSTWEGGVRVPTFVYWKGMIQPRKSDGIVDLADLFPTALDLAGHPGAKVANLVPKTTFIDGVDQTSFFLGTNGQSNRKAEHYFLNGKLAAVRMDEFKYHVLIQQPYAYTQSGYQGGFTGTVMQTAGSSVFNLYTDPQESDSIGVRHIPMGVPLQTEMHAYMEILKKYPPRAQIKSD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10089
Length:	551 (423)
Sequences:	3172 (2190)
Seq/√Len:	106.5

ECOLI - ASLA YDEN YIDJ
HALSA - Q9HSV3 Q9HQ44 Q9HQQ2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
415_D	438_D	6.014	1.00
341_E	346_L	5.241	1.00
470_E	506_N	4.639	1.00
284_D	339_T	4.089	1.00
338_K	342_K	4.057	1.00
470_E	508_Y	3.784	1.00
506_N	509_T	3.749	1.00
123_Q	390_Y	3.735	1.00
524_M	527_P	3.610	1.00
337_Y	351_I	3.197	1.00
102_G	118_D	3.139	1.00
280_V	339_T	3.127	1.00
472_K	513_E	3.074	1.00
88_V	176_L	3.035	1.00
116_D	334_A	2.989	1.00
93_L	96_V	2.921	1.00
119_A	341_E	2.908	1.00
297_Y	336_L	2.886	1.00
276_M	299_T	2.867	1.00
151_H	435_D	2.776	1.00
278_Y	281_K	2.756	1.00
279_G	295_L	2.668	1.00
281_K	285_K	2.623	1.00
350_L	389_V	2.570	1.00
139_T	406_L	2.563	1.00
468_M	527_P	2.549	1.00
404_V	439_Q	2.538	1.00
312_Y	331_D	2.518	1.00
339_T	343_N	2.489	1.00
359_P	368_R	2.466	1.00
179_Q	419_H	2.351	1.00
411_P	436_G	2.306	1.00
89_V	351_I	2.266	1.00
91_F	333_F	2.250	1.00
120_V	388_F	2.241	1.00
92_L	354_T	2.167	1.00
125_L	400_S	2.162	1.00
310_A	314_G	2.161	1.00
468_M	531_E	2.124	1.00
177_H	205_D	2.109	1.00
276_M	332_V	2.084	1.00
276_M	336_L	2.074	1.00
414_L	419_H	2.066	1.00
280_V	335_N	2.041	1.00
416_L	440_T	2.024	1.00
175_L	414_L	2.023	1.00
186_I	295_L	1.997	1.00
518_G	525_G	1.992	1.00
299_T	332_V	1.988	1.00
415_D	440_T	1.978	1.00
119_A	123_Q	1.965	1.00
339_T	342_K	1.962	1.00
130_A	404_V	1.940	1.00
277_D	335_N	1.916	1.00
352_V	413_A	1.901	1.00
90_V	352_V	1.895	1.00
284_D	343_N	1.895	1.00
129_S	467_R	1.861	1.00
346_L	390_Y	1.795	1.00
93_L	353_F	1.794	1.00
172_L	294_F	1.767	1.00
503_S	516_S	1.761	1.00
125_L	399_K	1.758	1.00
185_A	296_Y	1.748	1.00
273_Q	332_V	1.746	1.00
184_Q	282_F	1.733	1.00
113_P	327_V	1.726	1.00
409_L	413_A	1.713	1.00
132_S	385_V	1.707	1.00
517_I	521_H	1.700	1.00
314_G	324_D	1.695	1.00
271_L	275_W	1.694	1.00
116_D	119_A	1.685	1.00
350_L	416_L	1.670	1.00
88_V	417_A	1.659	1.00
96_V	302_C	1.656	1.00
337_Y	346_L	1.655	1.00
96_V	326_M	1.648	1.00
454_A	531_E	1.620	1.00
175_L	410_F	1.611	1.00
284_D	342_K	1.605	1.00
521_H	524_M	1.603	1.00
253_R	278_Y	1.601	1.00
313_A	324_D	1.600	1.00
346_L	351_I	1.597	1.00
89_V	295_L	1.592	1.00
103_F	126_I	1.581	1.00
389_V	395_I	1.578	1.00
206_D	285_K	1.577	1.00
341_E	390_Y	1.567	1.00
276_M	280_V	1.547	1.00
352_V	389_V	1.523	1.00
526_V	529_Q	1.513	1.00
142_T	149_S	1.506	1.00
440_T	444_L	1.497	1.00
394_M	444_L	1.482	1.00
251_A	254_G	1.460	1.00
92_L	143_I	1.453	1.00
308_P	313_A	1.448	1.00
182_V	291_K	1.444	1.00
117_I	353_F	1.439	1.00
125_L	395_I	1.425	1.00
309_N	312_Y	1.423	1.00
89_V	340_L	1.409	1.00
169_L	432_T	1.404	1.00
120_V	390_Y	1.399	1.00
473_Y	525_G	1.392	1.00
182_V	286_M	1.382	1.00
103_F	118_D	1.377	1.00
275_W	297_Y	1.372	1.00
379_W	503_S	1.372	1.00
92_L	406_L	1.372	1.00
350_L	413_A	1.357	1.00
273_Q	328_E	1.351	1.00
299_T	329_M	1.346	1.00
137_S	154_I	1.345	1.00
371_F	511_P	1.336	0.99
515_D	520_R	1.313	0.99
93_L	329_M	1.312	0.99
166_L	171_T	1.312	0.99
96_V	353_F	1.301	0.99
400_S	442_F	1.296	0.99
302_C	326_M	1.296	0.99
120_V	337_Y	1.296	0.99
335_N	338_K	1.291	0.99
147_Q	169_L	1.287	0.99
329_M	353_F	1.284	0.99
104_N	126_I	1.276	0.99
129_S	384_R	1.259	0.99
501_G	516_S	1.248	0.99
85_K	179_Q	1.241	0.99
441_S	446_T	1.235	0.99
471_F	517_I	1.232	0.99
174_Q	202_V	1.228	0.99
95_D	375_K	1.228	0.99
380_E	507_L	1.227	0.99
117_I	120_V	1.224	0.99
467_R	470_E	1.218	0.99
127_L	442_F	1.211	0.99
287_A	345_Q	1.207	0.99
530_T	534_A	1.202	0.99
280_V	284_D	1.194	0.99
88_V	416_L	1.191	0.99
310_A	313_A	1.186	0.99
84_K	348_N	1.177	0.99
196_E	201_N	1.158	0.98
123_Q	346_L	1.156	0.98
272_D	299_T	1.153	0.98
127_L	443_F	1.151	0.98
372_R	379_W	1.143	0.98
526_V	530_T	1.141	0.98
328_E	332_V	1.136	0.98
119_A	338_K	1.136	0.98
272_D	301_G	1.132	0.98
466_V	531_E	1.128	0.98
471_F	504_V	1.124	0.98
123_Q	341_E	1.120	0.98
351_I	390_Y	1.100	0.98
380_E	472_K	1.100	0.98
195_K	201_N	1.097	0.98
131_Y	383_V	1.093	0.98
350_L	391_W	1.092	0.98
329_M	333_F	1.091	0.98
128_T	401_D	1.089	0.98
185_A	189_W	1.086	0.98
213_V	216_M	1.085	0.98
119_A	337_Y	1.085	0.98
308_P	324_D	1.080	0.98
119_A	346_L	1.079	0.98
272_D	332_V	1.077	0.98
340_L	346_L	1.077	0.98
473_Y	502_S	1.073	0.98
524_M	528_L	1.071	0.97
337_Y	390_Y	1.070	0.97
312_Y	328_E	1.068	0.97
452_R	456_H	1.068	0.97
127_L	387_T	1.065	0.97
170_T	178_D	1.063	0.97
184_Q	295_L	1.062	0.97
182_V	205_D	1.061	0.97
118_D	122_S	1.061	0.97
207_F	210_F	1.058	0.97
283_L	336_L	1.057	0.97
454_A	468_M	1.056	0.97
98_W	128_T	1.054	0.97
208_R	274_R	1.051	0.97
438_D	441_S	1.051	0.97
387_T	409_L	1.050	0.97
337_Y	341_E	1.047	0.97
320_T	323_G	1.045	0.97
276_M	297_Y	1.032	0.97
132_S	139_T	1.023	0.97
361_A	374_A	1.023	0.97
468_M	528_L	1.021	0.97
91_F	351_I	1.017	0.97
279_G	297_Y	1.012	0.96
251_A	255_G	1.005	0.96
186_I	206_D	0.998	0.96
320_T	324_D	0.997	0.96
293_F	345_Q	0.992	0.96
373_G	377_S	0.992	0.96
355_S	385_V	0.986	0.96
286_M	289_S	0.985	0.96
174_Q	177_H	0.985	0.96
121_A	126_I	0.984	0.96
332_V	335_N	0.980	0.96
289_S	343_N	0.978	0.96
336_L	339_T	0.977	0.96
218_T	221_R	0.974	0.96
87_N	349_T	0.970	0.95
316_S	320_T	0.968	0.95
132_S	406_L	0.968	0.95
152_H	155_L	0.959	0.95
90_V	413_A	0.950	0.95
340_L	343_N	0.949	0.95
453_K	469_D	0.946	0.95
517_I	524_M	0.943	0.95
517_I	520_R	0.942	0.95
471_F	521_H	0.941	0.95
331_D	335_N	0.939	0.95
309_N	328_E	0.935	0.94
216_M	307_Y	0.935	0.94
428_V	431_T	0.926	0.94
92_L	298_G	0.921	0.94
185_A	298_G	0.917	0.94
130_A	387_T	0.917	0.94
184_Q	206_D	0.914	0.94
208_R	278_Y	0.913	0.94
531_E	534_A	0.911	0.94
455_E	458_F	0.909	0.94
204_F	296_Y	0.908	0.94
95_D	382_G	0.905	0.93
413_A	417_A	0.905	0.93
354_T	406_L	0.896	0.93
143_I	409_L	0.895	0.93
437_V	452_R	0.890	0.93
173_P	177_H	0.889	0.93
324_D	328_E	0.883	0.93
270_D	325_C	0.882	0.93
531_E	535_Y	0.882	0.93
352_V	409_L	0.881	0.93
124_G	388_F	0.881	0.93
237_E	240_K	0.879	0.92
525_G	529_Q	0.877	0.92
466_V	473_Y	0.874	0.92
176_L	414_L	0.870	0.92
338_K	341_E	0.868	0.92
437_V	451_N	0.868	0.92
172_L	410_F	0.867	0.92
394_M	397_P	0.867	0.92
89_V	349_T	0.865	0.92
456_H	466_V	0.864	0.92
340_L	351_I	0.862	0.92
189_W	192_G	0.862	0.92
359_P	367_G	0.861	0.92
370_P	511_P	0.854	0.91
490_G	494_G	0.854	0.91
313_A	321_S	0.851	0.91
273_Q	277_D	0.845	0.91
352_V	387_T	0.843	0.91
97_G	381_G	0.843	0.91
439_Q	451_N	0.842	0.91
312_Y	327_V	0.840	0.91
100_D	322_Y	0.838	0.91
380_E	384_R	0.836	0.90
88_V	413_A	0.835	0.90
530_T	533_H	0.835	0.90
170_T	175_L	0.834	0.90
253_R	256_E	0.834	0.90
130_A	406_L	0.832	0.90
272_D	328_E	0.831	0.90
275_W	300_R	0.831	0.90
134_P	378_T	0.830	0.90
114_T	118_D	0.828	0.90
470_E	524_M	0.828	0.90
89_V	293_F	0.828	0.90
235_R	240_K	0.828	0.90
466_V	532_M	0.827	0.90
90_V	409_L	0.824	0.90
87_N	293_F	0.824	0.90
282_F	286_M	0.823	0.90
316_S	323_G	0.822	0.90
108_V	112_N	0.821	0.90
452_R	457_Y	0.820	0.90
99_M	369_T	0.811	0.89
375_K	382_G	0.809	0.89
235_R	238_Y	0.808	0.89
308_P	325_C	0.804	0.89
283_L	286_M	0.803	0.89
90_V	143_I	0.803	0.89
173_P	176_L	0.801	0.89
450_S	453_K	0.800	0.88
177_H	183_T	0.799	0.88
345_Q	348_N	0.795	0.88
186_I	275_W	0.791	0.88
308_P	312_Y	0.791	0.88
391_W	394_M	0.790	0.88
144_L	204_F	0.789	0.88
100_D	367_G	0.786	0.88
276_M	335_N	0.783	0.87
97_G	357_N	0.780	0.87
234_D	238_Y	0.780	0.87
396_Q	399_K	0.776	0.87
173_P	202_V	0.775	0.87
496_V	499_T	0.774	0.87
527_P	531_E	0.772	0.87
270_D	328_E	0.767	0.86
348_N	393_G	0.765	0.86
466_V	528_L	0.764	0.86
96_V	117_I	0.762	0.86
473_Y	504_V	0.761	0.86
506_N	524_M	0.761	0.86
104_N	388_F	0.760	0.86
452_R	455_E	0.759	0.86
154_I	158_P	0.758	0.86
301_G	325_C	0.758	0.86
273_Q	309_N	0.755	0.85
384_R	511_P	0.751	0.85
90_V	354_T	0.749	0.85
489_Q	492_F	0.747	0.85
168_G	174_Q	0.746	0.85
103_F	388_F	0.746	0.85
270_D	273_Q	0.745	0.85
456_H	459_L	0.744	0.85
535_Y	538_I	0.743	0.84
473_Y	528_L	0.743	0.84
103_F	121_A	0.740	0.84
534_A	537_E	0.739	0.84
327_V	331_D	0.739	0.84
252_V	255_G	0.737	0.84
105_G	108_V	0.736	0.84
172_L	413_A	0.736	0.84
504_V	528_L	0.735	0.84
276_M	279_G	0.735	0.84
283_L	295_L	0.735	0.84
453_K	468_M	0.734	0.84
174_Q	178_D	0.733	0.84
185_A	207_F	0.733	0.84
210_F	215_D	0.732	0.84
95_D	357_N	0.732	0.84
269_E	274_R	0.731	0.84
471_F	524_M	0.731	0.84
315_S	327_V	0.727	0.83
96_V	101_V	0.727	0.83
236_S	240_K	0.727	0.83
129_S	507_L	0.727	0.83
490_G	493_T	0.725	0.83
472_K	507_L	0.724	0.83
404_V	441_S	0.724	0.83
182_V	282_F	0.723	0.83
176_L	417_A	0.722	0.83
238_Y	241_Q	0.720	0.83
468_M	524_M	0.720	0.83
357_N	381_G	0.719	0.82
137_S	190_H	0.718	0.82
378_T	465_A	0.715	0.82
492_F	495_T	0.714	0.82
236_S	239_I	0.709	0.82
504_V	516_S	0.707	0.81
170_T	432_T	0.707	0.81
91_F	336_L	0.707	0.81
116_D	337_Y	0.706	0.81
283_L	345_Q	0.705	0.81
409_L	439_Q	0.703	0.81
288_K	291_K	0.700	0.81
328_E	331_D	0.698	0.81
355_S	386_P	0.694	0.80
176_L	350_L	0.692	0.80
147_Q	152_H	0.688	0.80
489_Q	493_T	0.688	0.80
151_H	169_L	0.688	0.80
175_L	178_D	0.688	0.80
473_Y	529_Q	0.688	0.80
149_S	155_L	0.686	0.79
235_R	241_Q	0.685	0.79
360_E	366_H	0.685	0.79
102_G	121_A	0.684	0.79
459_L	464_A	0.684	0.79
176_L	413_A	0.682	0.79
152_H	169_L	0.681	0.79
150_I	458_F	0.681	0.79
104_N	387_T	0.679	0.79
400_S	403_I	0.678	0.79
362_E	365_P	0.678	0.79
378_T	474_H	0.677	0.79
213_V	218_T	0.676	0.78
457_Y	507_L	0.676	0.78
172_L	176_L	0.676	0.78
266_K	269_E	0.676	0.78
272_D	297_Y	0.675	0.78
97_G	359_P	0.674	0.78
144_L	296_Y	0.673	0.78
151_H	538_I	0.671	0.78
532_M	536_M	0.666	0.77
97_G	199_P	0.666	0.77
287_A	343_N	0.665	0.77
524_M	531_E	0.665	0.77
147_Q	167_Q	0.663	0.77
100_D	359_P	0.662	0.77
84_K	347_D	0.662	0.77
502_S	529_Q	0.662	0.77
311_K	331_D	0.660	0.77
125_L	443_F	0.660	0.77
380_E	467_R	0.658	0.77
145_T	171_T	0.654	0.76
457_Y	465_A	0.652	0.76
306_N	325_C	0.651	0.76
354_T	387_T	0.650	0.76
415_D	441_S	0.650	0.76
88_V	350_L	0.647	0.75
216_M	219_E	0.647	0.75
114_T	326_M	0.646	0.75
383_V	457_Y	0.645	0.75
101_V	126_I	0.644	0.75
150_I	456_H	0.643	0.75
254_G	258_Q	0.643	0.75
371_F	384_R	0.643	0.75
93_L	302_C	0.642	0.75
339_T	345_Q	0.642	0.75
348_N	396_Q	0.640	0.75
117_I	388_F	0.637	0.74
447_N	451_N	0.637	0.74
116_D	338_K	0.636	0.74
475_V	532_M	0.635	0.74
509_T	523_P	0.635	0.74
97_G	100_D	0.634	0.74
136_S	140_R	0.632	0.74
179_Q	417_A	0.631	0.74
469_D	506_N	0.630	0.73
465_A	472_K	0.629	0.73
516_S	519_V	0.629	0.73
307_Y	325_C	0.628	0.73
315_S	320_T	0.628	0.73
533_H	537_E	0.626	0.73
131_Y	403_I	0.625	0.73
494_G	497_M	0.624	0.73
389_V	443_F	0.624	0.73
411_P	434_I	0.623	0.73
410_F	434_I	0.623	0.73
185_A	209_G	0.622	0.73
505_F	516_S	0.622	0.73
308_P	321_S	0.622	0.73
141_A	152_H	0.621	0.72
101_V	117_I	0.621	0.72
133_Q	149_S	0.620	0.72
360_E	363_V	0.619	0.72
410_F	414_L	0.619	0.72
212_S	216_M	0.619	0.72
400_S	404_V	0.619	0.72
301_G	329_M	0.618	0.72
395_I	444_L	0.618	0.72
451_N	455_E	0.616	0.72
283_L	343_N	0.616	0.72
193_E	198_Q	0.613	0.71
395_I	399_K	0.613	0.71
131_Y	380_E	0.613	0.71
236_S	241_Q	0.610	0.71
534_A	538_I	0.610	0.71
206_D	254_G	0.609	0.71
117_I	333_F	0.607	0.71
150_I	155_L	0.606	0.71
141_A	154_I	0.606	0.71
441_S	451_N	0.601	0.70
401_D	508_Y	0.600	0.70
156_M	160_Y	0.599	0.70
357_N	382_G	0.598	0.70
218_T	307_Y	0.597	0.69
312_Y	324_D	0.597	0.69
144_L	191_M	0.597	0.69
520_R	523_P	0.595	0.69
454_A	457_Y	0.594	0.69
390_Y	397_P	0.594	0.69
527_P	534_A	0.594	0.69
293_F	340_L	0.594	0.69
165_G	197_S	0.593	0.69
465_A	474_H	0.593	0.69
100_D	189_W	0.591	0.69
122_S	398_R	0.589	0.68
200_Q	209_G	0.589	0.68
131_Y	149_S	0.588	0.68
416_L	444_L	0.587	0.68
98_W	370_P	0.587	0.68
402_G	450_S	0.587	0.68
291_K	528_L	0.586	0.68
89_V	297_Y	0.586	0.68
509_T	521_H	0.586	0.68
91_F	299_T	0.585	0.68
402_G	442_F	0.584	0.68
324_D	327_V	0.584	0.68
201_N	255_G	0.584	0.68
102_G	114_T	0.583	0.68
198_Q	201_N	0.583	0.68
391_W	395_I	0.583	0.68
325_C	328_E	0.583	0.68
301_G	328_E	0.581	0.67
212_S	215_D	0.580	0.67
173_P	185_A	0.580	0.67
122_S	126_I	0.580	0.67
522_I	526_V	0.579	0.67
378_T	383_V	0.578	0.67
93_L	326_M	0.576	0.67
151_H	539_L	0.576	0.67
189_W	202_V	0.574	0.66
373_G	382_G	0.573	0.66
456_H	535_Y	0.573	0.66
293_F	344_G	0.572	0.66
210_F	217_Y	0.572	0.66
148_Y	407_A	0.569	0.66
526_V	533_H	0.568	0.66
491_G	495_T	0.568	0.66
258_Q	261_A	0.567	0.65
293_F	349_T	0.567	0.65
489_Q	494_G	0.565	0.65
491_G	494_G	0.565	0.65
97_G	382_G	0.564	0.65
452_R	458_F	0.564	0.65
318_A	360_E	0.562	0.65
189_W	199_P	0.562	0.65
306_N	322_Y	0.562	0.65
405_D	455_E	0.561	0.65
280_V	338_K	0.561	0.65
99_M	370_P	0.560	0.65
391_W	416_L	0.560	0.65
210_F	216_M	0.560	0.65
308_P	314_G	0.560	0.65
96_V	329_M	0.559	0.64
154_I	191_M	0.559	0.64
529_Q	533_H	0.559	0.64
522_I	525_G	0.559	0.64
199_P	203_G	0.557	0.64
361_A	365_P	0.556	0.64
360_E	365_P	0.556	0.64
316_S	327_V	0.555	0.64
90_V	294_F	0.554	0.64
96_V	100_D	0.554	0.64
309_N	313_A	0.554	0.64
336_L	351_I	0.553	0.64
112_N	302_C	0.553	0.64
274_R	278_Y	0.553	0.64
145_T	191_M	0.552	0.63
170_T	173_P	0.552	0.63
283_L	340_L	0.552	0.63
143_I	406_L	0.551	0.63
186_I	297_Y	0.551	0.63
118_D	322_Y	0.551	0.63
201_N	254_G	0.551	0.63
347_D	401_D	0.550	0.63
123_Q	397_P	0.549	0.63
147_Q	433_F	0.549	0.63
234_D	240_K	0.549	0.63
289_S	340_L	0.549	0.63
140_R	187_G	0.548	0.63
439_Q	443_F	0.548	0.63
451_N	456_H	0.547	0.63
213_V	217_Y	0.547	0.63
234_D	237_E	0.547	0.63
316_S	324_D	0.546	0.63
280_V	332_V	0.545	0.62
277_D	280_V	0.544	0.62
79_E	82_T	0.544	0.62
359_P	366_H	0.543	0.62
120_V	351_I	0.543	0.62
98_W	371_F	0.542	0.62
127_L	389_V	0.542	0.62
237_E	241_Q	0.541	0.62
379_W	476_L	0.541	0.62
265_P	268_M	0.540	0.62
84_K	122_S	0.539	0.62
361_A	368_R	0.537	0.61
475_V	529_Q	0.537	0.61
459_L	462_K	0.537	0.61
99_M	512_Q	0.536	0.61
235_R	239_I	0.536	0.61
120_V	346_L	0.535	0.61
87_N	345_Q	0.534	0.61
214_S	218_T	0.534	0.61
120_V	124_G	0.532	0.61
101_V	118_D	0.531	0.60
114_T	117_I	0.530	0.60
215_D	218_T	0.529	0.60
125_L	398_R	0.529	0.60
290_D	396_Q	0.529	0.60
372_R	505_F	0.529	0.60
82_T	85_K	0.529	0.60
391_W	435_D	0.528	0.60
175_L	419_H	0.528	0.60
471_F	506_N	0.528	0.60
139_T	366_H	0.528	0.60
93_L	333_F	0.527	0.60
286_M	295_L	0.526	0.60
140_R	188_K	0.526	0.60
199_P	381_G	0.526	0.60
194_N	198_Q	0.525	0.60
103_F	113_P	0.525	0.60
458_F	463_L	0.524	0.59
407_A	434_I	0.523	0.59
272_D	329_M	0.523	0.59
170_T	174_Q	0.523	0.59
89_V	337_Y	0.522	0.59
439_Q	444_L	0.521	0.59
98_W	357_N	0.520	0.59
101_V	104_N	0.519	0.59
103_F	117_I	0.518	0.59
210_F	300_R	0.518	0.59
277_D	281_K	0.518	0.59
354_T	409_L	0.518	0.59
102_G	113_P	0.518	0.59
315_S	318_A	0.518	0.59
271_L	300_R	0.517	0.58
101_V	388_F	0.517	0.58
311_K	314_G	0.517	0.58
84_K	290_D	0.515	0.58
518_G	522_I	0.515	0.58
418_G	520_R	0.515	0.58
141_A	153_G	0.514	0.58
197_S	202_V	0.514	0.58
280_V	336_L	0.513	0.58
474_H	477_I	0.511	0.58
95_D	359_P	0.510	0.57
341_E	351_I	0.510	0.57
92_L	139_T	0.509	0.57
99_M	105_G	0.508	0.57
281_K	284_D	0.508	0.57
493_T	496_V	0.506	0.57
304_F	360_E	0.506	0.57
200_Q	255_G	0.505	0.57
178_D	183_T	0.505	0.57
95_D	187_G	0.505	0.57
139_T	407_A	0.504	0.57
429_P	432_T	0.503	0.56
97_G	203_G	0.503	0.56
199_P	357_N	0.502	0.56
455_E	459_L	0.501	0.56
380_E	513_E	0.500	0.56

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1p49A	3	0.8131	100	0.336	Contact Map
1hdhA	1	0.7459	100	0.345	Contact Map
1aukA	3	0.804	100	0.351	Contact Map
4fdiA	2	0.7895	100	0.357	Contact Map
1fsuA	1	0.7913	100	0.358	Contact Map
4uplA	2	0.7586	100	0.366	Contact Map
3ed4A	3	0.7659	100	0.366	Contact Map
2vqrA	3	0.7568	100	0.367	Contact Map
4upiA	2	0.7586	100	0.368	Contact Map
4uphA	2	0.7568	100	0.374	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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