GREMLIN Database
ASLA - Arylsulfatase
UniProt: P25549 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10089
Length: 551 (423)
Sequences: 3172 (2190)
Seq/√Len: 106.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
415_D438_D6.0141.00
341_E346_L5.2411.00
470_E506_N4.6391.00
284_D339_T4.0891.00
338_K342_K4.0571.00
470_E508_Y3.7841.00
506_N509_T3.7491.00
123_Q390_Y3.7351.00
524_M527_P3.6101.00
337_Y351_I3.1971.00
102_G118_D3.1391.00
280_V339_T3.1271.00
472_K513_E3.0741.00
88_V176_L3.0351.00
116_D334_A2.9891.00
93_L96_V2.9211.00
119_A341_E2.9081.00
297_Y336_L2.8861.00
276_M299_T2.8671.00
151_H435_D2.7761.00
278_Y281_K2.7561.00
279_G295_L2.6681.00
281_K285_K2.6231.00
350_L389_V2.5701.00
139_T406_L2.5631.00
468_M527_P2.5491.00
404_V439_Q2.5381.00
312_Y331_D2.5181.00
339_T343_N2.4891.00
359_P368_R2.4661.00
179_Q419_H2.3511.00
411_P436_G2.3061.00
89_V351_I2.2661.00
91_F333_F2.2501.00
120_V388_F2.2411.00
92_L354_T2.1671.00
125_L400_S2.1621.00
310_A314_G2.1611.00
468_M531_E2.1241.00
177_H205_D2.1091.00
276_M332_V2.0841.00
276_M336_L2.0741.00
414_L419_H2.0661.00
280_V335_N2.0411.00
416_L440_T2.0241.00
175_L414_L2.0231.00
186_I295_L1.9971.00
518_G525_G1.9921.00
299_T332_V1.9881.00
415_D440_T1.9781.00
119_A123_Q1.9651.00
339_T342_K1.9621.00
130_A404_V1.9401.00
277_D335_N1.9161.00
352_V413_A1.9011.00
90_V352_V1.8951.00
284_D343_N1.8951.00
129_S467_R1.8611.00
346_L390_Y1.7951.00
93_L353_F1.7941.00
172_L294_F1.7671.00
503_S516_S1.7611.00
125_L399_K1.7581.00
185_A296_Y1.7481.00
273_Q332_V1.7461.00
184_Q282_F1.7331.00
113_P327_V1.7261.00
409_L413_A1.7131.00
132_S385_V1.7071.00
517_I521_H1.7001.00
314_G324_D1.6951.00
271_L275_W1.6941.00
116_D119_A1.6851.00
350_L416_L1.6701.00
88_V417_A1.6591.00
96_V302_C1.6561.00
337_Y346_L1.6551.00
96_V326_M1.6481.00
454_A531_E1.6201.00
175_L410_F1.6111.00
284_D342_K1.6051.00
521_H524_M1.6031.00
253_R278_Y1.6011.00
313_A324_D1.6001.00
346_L351_I1.5971.00
89_V295_L1.5921.00
103_F126_I1.5811.00
389_V395_I1.5781.00
206_D285_K1.5771.00
341_E390_Y1.5671.00
276_M280_V1.5471.00
352_V389_V1.5231.00
526_V529_Q1.5131.00
142_T149_S1.5061.00
440_T444_L1.4971.00
394_M444_L1.4821.00
251_A254_G1.4601.00
92_L143_I1.4531.00
308_P313_A1.4481.00
182_V291_K1.4441.00
117_I353_F1.4391.00
125_L395_I1.4251.00
309_N312_Y1.4231.00
89_V340_L1.4091.00
169_L432_T1.4041.00
120_V390_Y1.3991.00
473_Y525_G1.3921.00
182_V286_M1.3821.00
103_F118_D1.3771.00
275_W297_Y1.3721.00
379_W503_S1.3721.00
92_L406_L1.3721.00
350_L413_A1.3571.00
273_Q328_E1.3511.00
299_T329_M1.3461.00
137_S154_I1.3451.00
371_F511_P1.3360.99
515_D520_R1.3130.99
93_L329_M1.3120.99
166_L171_T1.3120.99
96_V353_F1.3010.99
400_S442_F1.2960.99
302_C326_M1.2960.99
120_V337_Y1.2960.99
335_N338_K1.2910.99
147_Q169_L1.2870.99
329_M353_F1.2840.99
104_N126_I1.2760.99
129_S384_R1.2590.99
501_G516_S1.2480.99
85_K179_Q1.2410.99
441_S446_T1.2350.99
471_F517_I1.2320.99
174_Q202_V1.2280.99
95_D375_K1.2280.99
380_E507_L1.2270.99
117_I120_V1.2240.99
467_R470_E1.2180.99
127_L442_F1.2110.99
287_A345_Q1.2070.99
530_T534_A1.2020.99
280_V284_D1.1940.99
88_V416_L1.1910.99
310_A313_A1.1860.99
84_K348_N1.1770.99
196_E201_N1.1580.98
123_Q346_L1.1560.98
272_D299_T1.1530.98
127_L443_F1.1510.98
372_R379_W1.1430.98
526_V530_T1.1410.98
328_E332_V1.1360.98
119_A338_K1.1360.98
272_D301_G1.1320.98
466_V531_E1.1280.98
471_F504_V1.1240.98
123_Q341_E1.1200.98
351_I390_Y1.1000.98
380_E472_K1.1000.98
195_K201_N1.0970.98
131_Y383_V1.0930.98
350_L391_W1.0920.98
329_M333_F1.0910.98
128_T401_D1.0890.98
185_A189_W1.0860.98
213_V216_M1.0850.98
119_A337_Y1.0850.98
308_P324_D1.0800.98
119_A346_L1.0790.98
272_D332_V1.0770.98
340_L346_L1.0770.98
473_Y502_S1.0730.98
524_M528_L1.0710.97
337_Y390_Y1.0700.97
312_Y328_E1.0680.97
452_R456_H1.0680.97
127_L387_T1.0650.97
170_T178_D1.0630.97
184_Q295_L1.0620.97
182_V205_D1.0610.97
118_D122_S1.0610.97
207_F210_F1.0580.97
283_L336_L1.0570.97
454_A468_M1.0560.97
98_W128_T1.0540.97
208_R274_R1.0510.97
438_D441_S1.0510.97
387_T409_L1.0500.97
337_Y341_E1.0470.97
320_T323_G1.0450.97
276_M297_Y1.0320.97
132_S139_T1.0230.97
361_A374_A1.0230.97
468_M528_L1.0210.97
91_F351_I1.0170.97
279_G297_Y1.0120.96
251_A255_G1.0050.96
186_I206_D0.9980.96
320_T324_D0.9970.96
293_F345_Q0.9920.96
373_G377_S0.9920.96
355_S385_V0.9860.96
286_M289_S0.9850.96
174_Q177_H0.9850.96
121_A126_I0.9840.96
332_V335_N0.9800.96
289_S343_N0.9780.96
336_L339_T0.9770.96
218_T221_R0.9740.96
87_N349_T0.9700.95
316_S320_T0.9680.95
132_S406_L0.9680.95
152_H155_L0.9590.95
90_V413_A0.9500.95
340_L343_N0.9490.95
453_K469_D0.9460.95
517_I524_M0.9430.95
517_I520_R0.9420.95
471_F521_H0.9410.95
331_D335_N0.9390.95
309_N328_E0.9350.94
216_M307_Y0.9350.94
428_V431_T0.9260.94
92_L298_G0.9210.94
185_A298_G0.9170.94
130_A387_T0.9170.94
184_Q206_D0.9140.94
208_R278_Y0.9130.94
531_E534_A0.9110.94
455_E458_F0.9090.94
204_F296_Y0.9080.94
95_D382_G0.9050.93
413_A417_A0.9050.93
354_T406_L0.8960.93
143_I409_L0.8950.93
437_V452_R0.8900.93
173_P177_H0.8890.93
324_D328_E0.8830.93
270_D325_C0.8820.93
531_E535_Y0.8820.93
352_V409_L0.8810.93
124_G388_F0.8810.93
237_E240_K0.8790.92
525_G529_Q0.8770.92
466_V473_Y0.8740.92
176_L414_L0.8700.92
338_K341_E0.8680.92
437_V451_N0.8680.92
172_L410_F0.8670.92
394_M397_P0.8670.92
89_V349_T0.8650.92
456_H466_V0.8640.92
340_L351_I0.8620.92
189_W192_G0.8620.92
359_P367_G0.8610.92
370_P511_P0.8540.91
490_G494_G0.8540.91
313_A321_S0.8510.91
273_Q277_D0.8450.91
352_V387_T0.8430.91
97_G381_G0.8430.91
439_Q451_N0.8420.91
312_Y327_V0.8400.91
100_D322_Y0.8380.91
380_E384_R0.8360.90
88_V413_A0.8350.90
530_T533_H0.8350.90
170_T175_L0.8340.90
253_R256_E0.8340.90
130_A406_L0.8320.90
272_D328_E0.8310.90
275_W300_R0.8310.90
134_P378_T0.8300.90
114_T118_D0.8280.90
470_E524_M0.8280.90
89_V293_F0.8280.90
235_R240_K0.8280.90
466_V532_M0.8270.90
90_V409_L0.8240.90
87_N293_F0.8240.90
282_F286_M0.8230.90
316_S323_G0.8220.90
108_V112_N0.8210.90
452_R457_Y0.8200.90
99_M369_T0.8110.89
375_K382_G0.8090.89
235_R238_Y0.8080.89
308_P325_C0.8040.89
283_L286_M0.8030.89
90_V143_I0.8030.89
173_P176_L0.8010.89
450_S453_K0.8000.88
177_H183_T0.7990.88
345_Q348_N0.7950.88
186_I275_W0.7910.88
308_P312_Y0.7910.88
391_W394_M0.7900.88
144_L204_F0.7890.88
100_D367_G0.7860.88
276_M335_N0.7830.87
97_G357_N0.7800.87
234_D238_Y0.7800.87
396_Q399_K0.7760.87
173_P202_V0.7750.87
496_V499_T0.7740.87
527_P531_E0.7720.87
270_D328_E0.7670.86
348_N393_G0.7650.86
466_V528_L0.7640.86
96_V117_I0.7620.86
473_Y504_V0.7610.86
506_N524_M0.7610.86
104_N388_F0.7600.86
452_R455_E0.7590.86
154_I158_P0.7580.86
301_G325_C0.7580.86
273_Q309_N0.7550.85
384_R511_P0.7510.85
90_V354_T0.7490.85
489_Q492_F0.7470.85
168_G174_Q0.7460.85
103_F388_F0.7460.85
270_D273_Q0.7450.85
456_H459_L0.7440.85
535_Y538_I0.7430.84
473_Y528_L0.7430.84
103_F121_A0.7400.84
534_A537_E0.7390.84
327_V331_D0.7390.84
252_V255_G0.7370.84
105_G108_V0.7360.84
172_L413_A0.7360.84
504_V528_L0.7350.84
276_M279_G0.7350.84
283_L295_L0.7350.84
453_K468_M0.7340.84
174_Q178_D0.7330.84
185_A207_F0.7330.84
210_F215_D0.7320.84
95_D357_N0.7320.84
269_E274_R0.7310.84
471_F524_M0.7310.84
315_S327_V0.7270.83
96_V101_V0.7270.83
236_S240_K0.7270.83
129_S507_L0.7270.83
490_G493_T0.7250.83
472_K507_L0.7240.83
404_V441_S0.7240.83
182_V282_F0.7230.83
176_L417_A0.7220.83
238_Y241_Q0.7200.83
468_M524_M0.7200.83
357_N381_G0.7190.82
137_S190_H0.7180.82
378_T465_A0.7150.82
492_F495_T0.7140.82
236_S239_I0.7090.82
504_V516_S0.7070.81
170_T432_T0.7070.81
91_F336_L0.7070.81
116_D337_Y0.7060.81
283_L345_Q0.7050.81
409_L439_Q0.7030.81
288_K291_K0.7000.81
328_E331_D0.6980.81
355_S386_P0.6940.80
176_L350_L0.6920.80
147_Q152_H0.6880.80
489_Q493_T0.6880.80
151_H169_L0.6880.80
175_L178_D0.6880.80
473_Y529_Q0.6880.80
149_S155_L0.6860.79
235_R241_Q0.6850.79
360_E366_H0.6850.79
102_G121_A0.6840.79
459_L464_A0.6840.79
176_L413_A0.6820.79
152_H169_L0.6810.79
150_I458_F0.6810.79
104_N387_T0.6790.79
400_S403_I0.6780.79
362_E365_P0.6780.79
378_T474_H0.6770.79
213_V218_T0.6760.78
457_Y507_L0.6760.78
172_L176_L0.6760.78
266_K269_E0.6760.78
272_D297_Y0.6750.78
97_G359_P0.6740.78
144_L296_Y0.6730.78
151_H538_I0.6710.78
532_M536_M0.6660.77
97_G199_P0.6660.77
287_A343_N0.6650.77
524_M531_E0.6650.77
147_Q167_Q0.6630.77
100_D359_P0.6620.77
84_K347_D0.6620.77
502_S529_Q0.6620.77
311_K331_D0.6600.77
125_L443_F0.6600.77
380_E467_R0.6580.77
145_T171_T0.6540.76
457_Y465_A0.6520.76
306_N325_C0.6510.76
354_T387_T0.6500.76
415_D441_S0.6500.76
88_V350_L0.6470.75
216_M219_E0.6470.75
114_T326_M0.6460.75
383_V457_Y0.6450.75
101_V126_I0.6440.75
150_I456_H0.6430.75
254_G258_Q0.6430.75
371_F384_R0.6430.75
93_L302_C0.6420.75
339_T345_Q0.6420.75
348_N396_Q0.6400.75
117_I388_F0.6370.74
447_N451_N0.6370.74
116_D338_K0.6360.74
475_V532_M0.6350.74
509_T523_P0.6350.74
97_G100_D0.6340.74
136_S140_R0.6320.74
179_Q417_A0.6310.74
469_D506_N0.6300.73
465_A472_K0.6290.73
516_S519_V0.6290.73
307_Y325_C0.6280.73
315_S320_T0.6280.73
533_H537_E0.6260.73
131_Y403_I0.6250.73
494_G497_M0.6240.73
389_V443_F0.6240.73
411_P434_I0.6230.73
410_F434_I0.6230.73
185_A209_G0.6220.73
505_F516_S0.6220.73
308_P321_S0.6220.73
141_A152_H0.6210.72
101_V117_I0.6210.72
133_Q149_S0.6200.72
360_E363_V0.6190.72
410_F414_L0.6190.72
212_S216_M0.6190.72
400_S404_V0.6190.72
301_G329_M0.6180.72
395_I444_L0.6180.72
451_N455_E0.6160.72
283_L343_N0.6160.72
193_E198_Q0.6130.71
395_I399_K0.6130.71
131_Y380_E0.6130.71
236_S241_Q0.6100.71
534_A538_I0.6100.71
206_D254_G0.6090.71
117_I333_F0.6070.71
150_I155_L0.6060.71
141_A154_I0.6060.71
441_S451_N0.6010.70
401_D508_Y0.6000.70
156_M160_Y0.5990.70
357_N382_G0.5980.70
218_T307_Y0.5970.69
312_Y324_D0.5970.69
144_L191_M0.5970.69
520_R523_P0.5950.69
454_A457_Y0.5940.69
390_Y397_P0.5940.69
527_P534_A0.5940.69
293_F340_L0.5940.69
165_G197_S0.5930.69
465_A474_H0.5930.69
100_D189_W0.5910.69
122_S398_R0.5890.68
200_Q209_G0.5890.68
131_Y149_S0.5880.68
416_L444_L0.5870.68
98_W370_P0.5870.68
402_G450_S0.5870.68
291_K528_L0.5860.68
89_V297_Y0.5860.68
509_T521_H0.5860.68
91_F299_T0.5850.68
402_G442_F0.5840.68
324_D327_V0.5840.68
201_N255_G0.5840.68
102_G114_T0.5830.68
198_Q201_N0.5830.68
391_W395_I0.5830.68
325_C328_E0.5830.68
301_G328_E0.5810.67
212_S215_D0.5800.67
173_P185_A0.5800.67
122_S126_I0.5800.67
522_I526_V0.5790.67
378_T383_V0.5780.67
93_L326_M0.5760.67
151_H539_L0.5760.67
189_W202_V0.5740.66
373_G382_G0.5730.66
456_H535_Y0.5730.66
293_F344_G0.5720.66
210_F217_Y0.5720.66
148_Y407_A0.5690.66
526_V533_H0.5680.66
491_G495_T0.5680.66
258_Q261_A0.5670.65
293_F349_T0.5670.65
489_Q494_G0.5650.65
491_G494_G0.5650.65
97_G382_G0.5640.65
452_R458_F0.5640.65
318_A360_E0.5620.65
189_W199_P0.5620.65
306_N322_Y0.5620.65
405_D455_E0.5610.65
280_V338_K0.5610.65
99_M370_P0.5600.65
391_W416_L0.5600.65
210_F216_M0.5600.65
308_P314_G0.5600.65
96_V329_M0.5590.64
154_I191_M0.5590.64
529_Q533_H0.5590.64
522_I525_G0.5590.64
199_P203_G0.5570.64
361_A365_P0.5560.64
360_E365_P0.5560.64
316_S327_V0.5550.64
90_V294_F0.5540.64
96_V100_D0.5540.64
309_N313_A0.5540.64
336_L351_I0.5530.64
112_N302_C0.5530.64
274_R278_Y0.5530.64
145_T191_M0.5520.63
170_T173_P0.5520.63
283_L340_L0.5520.63
143_I406_L0.5510.63
186_I297_Y0.5510.63
118_D322_Y0.5510.63
201_N254_G0.5510.63
347_D401_D0.5500.63
123_Q397_P0.5490.63
147_Q433_F0.5490.63
234_D240_K0.5490.63
289_S340_L0.5490.63
140_R187_G0.5480.63
439_Q443_F0.5480.63
451_N456_H0.5470.63
213_V217_Y0.5470.63
234_D237_E0.5470.63
316_S324_D0.5460.63
280_V332_V0.5450.62
277_D280_V0.5440.62
79_E82_T0.5440.62
359_P366_H0.5430.62
120_V351_I0.5430.62
98_W371_F0.5420.62
127_L389_V0.5420.62
237_E241_Q0.5410.62
379_W476_L0.5410.62
265_P268_M0.5400.62
84_K122_S0.5390.62
361_A368_R0.5370.61
475_V529_Q0.5370.61
459_L462_K0.5370.61
99_M512_Q0.5360.61
235_R239_I0.5360.61
120_V346_L0.5350.61
87_N345_Q0.5340.61
214_S218_T0.5340.61
120_V124_G0.5320.61
101_V118_D0.5310.60
114_T117_I0.5300.60
215_D218_T0.5290.60
125_L398_R0.5290.60
290_D396_Q0.5290.60
372_R505_F0.5290.60
82_T85_K0.5290.60
391_W435_D0.5280.60
175_L419_H0.5280.60
471_F506_N0.5280.60
139_T366_H0.5280.60
93_L333_F0.5270.60
286_M295_L0.5260.60
140_R188_K0.5260.60
199_P381_G0.5260.60
194_N198_Q0.5250.60
103_F113_P0.5250.60
458_F463_L0.5240.59
407_A434_I0.5230.59
272_D329_M0.5230.59
170_T174_Q0.5230.59
89_V337_Y0.5220.59
439_Q444_L0.5210.59
98_W357_N0.5200.59
101_V104_N0.5190.59
103_F117_I0.5180.59
210_F300_R0.5180.59
277_D281_K0.5180.59
354_T409_L0.5180.59
102_G113_P0.5180.59
315_S318_A0.5180.59
271_L300_R0.5170.58
101_V388_F0.5170.58
311_K314_G0.5170.58
84_K290_D0.5150.58
518_G522_I0.5150.58
418_G520_R0.5150.58
141_A153_G0.5140.58
197_S202_V0.5140.58
280_V336_L0.5130.58
474_H477_I0.5110.58
95_D359_P0.5100.57
341_E351_I0.5100.57
92_L139_T0.5090.57
99_M105_G0.5080.57
281_K284_D0.5080.57
493_T496_V0.5060.57
304_F360_E0.5060.57
200_Q255_G0.5050.57
178_D183_T0.5050.57
95_D187_G0.5050.57
139_T407_A0.5040.57
429_P432_T0.5030.56
97_G203_G0.5030.56
199_P357_N0.5020.56
455_E459_L0.5010.56
380_E513_E0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1p49A 3 0.8131 100 0.336 Contact Map
1hdhA 1 0.7459 100 0.345 Contact Map
1aukA 3 0.804 100 0.351 Contact Map
4fdiA 2 0.7895 100 0.357 Contact Map
1fsuA 1 0.7913 100 0.358 Contact Map
4uplA 2 0.7586 100 0.366 Contact Map
3ed4A 3 0.7659 100 0.366 Contact Map
2vqrA 3 0.7568 100 0.367 Contact Map
4upiA 2 0.7586 100 0.368 Contact Map
4uphA 2 0.7568 100 0.374 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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