GREMLIN Database
YHDE - Maf-like protein YhdE
UniProt: P25536 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11298
Length: 197 (183)
Sequences: 5654 (4120)
Seq/√Len: 304.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
94_R131_D2.9841.00
86_A139_A2.8461.00
100_T125_T2.7711.00
78_E95_K2.7421.00
90_A135_A2.7311.00
76_N99_Q2.4931.00
14_Q18_A2.3811.00
88_H91_Q2.3151.00
102_Q123_D2.2951.00
102_Q121_V2.2731.00
123_D164_N2.1711.00
46_V119_L2.1641.00
31_I51_E2.0371.00
125_T161_R2.0251.00
125_T162_K2.0231.00
49_A108_A2.0101.00
3_S25_E1.9741.00
90_A138_V1.9131.00
100_T123_D1.8851.00
50_R54_R1.8441.00
84_R88_H1.7991.00
122_T170_V1.7971.00
116_L184_N1.7641.00
130_T133_D1.7511.00
97_S129_L1.6341.00
86_A138_V1.6171.00
14_Q24_F1.6081.00
108_A117_D1.6071.00
138_V144_L1.6051.00
54_R115_I1.5911.00
120_V169_A1.5891.00
104_M121_V1.5741.00
122_T169_A1.5491.00
75_L99_Q1.5241.00
129_L134_I1.5201.00
39_E47_R1.5171.00
156_G159_F1.5061.00
173_L178_T1.4941.00
116_L181_L1.4921.00
53_A68_G1.4841.00
120_V177_E1.4821.00
9_G28_V1.4791.00
50_R117_D1.4531.00
86_A90_A1.4511.00
90_A94_R1.4501.00
27_I59_Q1.4461.00
118_C177_E1.4331.00
86_A144_L1.4161.00
18_A24_F1.4031.00
90_A134_I1.3881.00
15_E19_Q1.3781.00
29_T56_G1.3741.00
142_E154_G1.3641.00
92_M149_A1.3641.00
118_C181_L1.3641.00
4_L67_L1.3641.00
167_Y171_V1.3221.00
50_R115_I1.2991.00
104_M119_L1.2981.00
107_V118_C1.2811.00
127_R176_V1.2761.00
74_I104_M1.2581.00
53_A110_A1.2571.00
40_S43_Q1.2541.00
97_S128_T1.2541.00
158_C179_Y1.2381.00
131_D135_A1.2351.00
97_S131_D1.2261.00
46_V117_D1.2121.00
127_R180_E1.2081.00
86_A135_A1.2081.00
101_H150_Y1.1951.00
91_Q95_K1.1791.00
127_R133_D1.1761.00
7_A68_G1.1751.00
44_Y72_I1.1741.00
47_R51_E1.1361.00
109_L181_L1.1311.00
75_L95_K1.1301.00
80_L92_M1.1221.00
85_D88_H1.1171.00
55_A59_Q1.1061.00
89_A149_A1.1031.00
107_V178_T1.1001.00
127_R161_R1.1001.00
12_R145_D1.0981.00
67_L178_T1.0971.00
14_Q26_R1.0921.00
3_S64_L1.0891.00
138_V143_P1.0781.00
27_I60_T1.0741.00
133_D183_S1.0671.00
116_L185_F1.0631.00
132_E136_G1.0561.00
90_A131_D1.0411.00
146_K151_G1.0341.00
50_R108_A1.0271.00
9_G29_T1.0121.00
122_T163_I1.0101.00
67_L109_L1.0061.00
89_A143_P1.0041.00
15_E18_A1.0001.00
19_Q157_G0.9941.00
152_I171_V0.9941.00
44_Y79_V0.9891.00
30_G55_A0.9861.00
110_A115_I0.9751.00
135_A139_A0.9731.00
36_Q51_E0.9731.00
126_F156_G0.9721.00
35_R44_Y0.9631.00
5_Y64_L0.9621.00
94_R134_I0.9551.00
72_I79_V0.9441.00
44_Y48_L0.9401.00
74_I77_G0.9381.00
111_D185_F0.9331.00
69_A105_T0.9291.00
141_D144_L0.9251.00
163_I170_V0.9191.00
45_V106_A0.9191.00
80_L95_K0.9181.00
88_H92_M0.9021.00
31_I55_A0.8961.00
27_I56_G0.8891.00
5_Y27_I0.8881.00
31_I48_L0.8831.00
177_E181_L0.8801.00
51_E54_R0.8741.00
93_L149_A0.8731.00
125_T164_N0.8671.00
140_S155_L0.8671.00
179_Y183_S0.8641.00
89_A138_V0.8481.00
18_A23_T0.8451.00
45_V104_M0.8331.00
56_G66_V0.8301.00
57_V110_A0.8271.00
36_Q47_R0.8261.00
74_I102_Q0.8171.00
42_Q46_V0.8141.00
107_V174_P0.8121.00
136_G139_A0.8111.00
65_P109_L0.8111.00
36_Q39_E0.8041.00
5_Y56_G0.8031.00
78_E91_Q0.8021.00
108_A115_I0.8011.00
43_Q46_V0.7971.00
96_L150_Y0.7901.00
142_E155_L0.7901.00
46_V50_R0.7871.00
20_L179_Y0.7820.99
107_V181_L0.7810.99
109_L178_T0.7800.99
54_R110_A0.7780.99
96_L101_H0.7700.99
12_R153_Q0.7690.99
181_L184_N0.7690.99
16_L175_L0.7670.99
67_L173_L0.7630.99
16_L173_L0.7580.99
106_A169_A0.7550.99
129_L159_F0.7470.99
87_E91_Q0.7450.99
168_H175_L0.7450.99
76_N95_K0.7400.99
41_A79_V0.7400.99
106_A119_L0.7360.99
21_G140_S0.7360.99
114_H185_F0.7260.99
17_L24_F0.7140.99
68_G110_A0.7130.99
166_S176_V0.7080.99
81_E147_A0.7060.99
118_C184_N0.7060.99
29_T55_A0.7050.99
56_G68_G0.7050.99
118_C180_E0.7040.99
53_A108_A0.7030.99
75_L96_L0.7010.99
75_L80_L0.6970.99
73_V103_V0.6960.99
111_D114_H0.6930.99
35_R79_V0.6920.99
71_T103_V0.6900.99
42_Q121_V0.6880.99
74_I79_V0.6870.99
44_Y47_R0.6800.99
27_I64_L0.6760.98
12_R15_E0.6750.98
166_S169_A0.6700.98
168_H171_V0.6660.98
45_V72_I0.6630.98
161_R180_E0.6630.98
48_L51_E0.6610.98
4_L22_V0.6610.98
98_G128_T0.6580.98
86_A141_D0.6580.98
12_R146_K0.6540.98
73_V80_L0.6520.98
42_Q119_L0.6500.98
17_L67_L0.6500.98
85_D91_Q0.6500.98
134_I138_V0.6490.98
178_T181_L0.6460.98
146_K153_Q0.6440.98
54_R58_A0.6420.98
150_Y160_V0.6400.98
48_L68_G0.6360.98
57_V66_V0.6360.98
109_L185_F0.6300.98
16_L171_V0.6230.97
60_T64_L0.6220.97
16_L168_H0.6180.97
16_L19_Q0.6160.97
41_A45_V0.6150.97
141_D154_G0.6130.97
66_V110_A0.6120.97
81_E92_M0.6070.97
69_A169_A0.6050.97
89_A93_L0.6040.97
122_T165_G0.6020.97
136_G140_S0.5990.97
163_I167_Y0.5990.97
68_G108_A0.5970.97
132_E135_A0.5830.96
47_R50_R0.5820.96
97_S134_I0.5820.96
51_E55_A0.5810.96
63_D111_D0.5780.96
26_R56_G0.5770.96
25_E64_L0.5760.96
20_L175_L0.5740.96
72_I81_E0.5700.96
40_S44_Y0.5690.96
22_V179_Y0.5670.96
155_L158_C0.5660.96
91_Q94_R0.5620.95
39_E44_Y0.5610.95
9_G31_I0.5600.95
105_T174_P0.5590.95
42_Q102_Q0.5570.95
4_L65_P0.5570.95
87_E90_A0.5560.95
135_A138_V0.5520.95
65_P111_D0.5510.95
9_G26_R0.5500.95
9_G30_G0.5470.95
152_I167_Y0.5450.95
157_G175_L0.5450.95
124_V160_V0.5400.94
42_Q104_M0.5390.94
181_L185_F0.5370.94
49_A68_G0.5360.94
65_P182_L0.5350.94
69_A173_L0.5330.94
44_Y81_E0.5300.94
35_R39_E0.5270.94
60_T63_D0.5250.93
71_T153_Q0.5250.93
67_L107_V0.5230.93
12_R171_V0.5230.93
84_R145_D0.5220.93
140_S143_P0.5200.93
41_A74_I0.5190.93
168_H176_V0.5190.93
57_V60_T0.5150.93
50_R110_A0.5090.92
100_T164_N0.5080.92
126_F129_L0.5070.92
65_P185_F0.5060.92
176_V180_E0.5040.92
93_L138_V0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ex2A 2 0.934 100 0.041 Contact Map
4jhcA 2 0.9645 100 0.045 Contact Map
4p0eA 2 0.9594 100 0.051 Contact Map
4oo0A 2 0.9594 100 0.051 Contact Map
2p5xA 1 0.9492 100 0.062 Contact Map
2amhA 1 0.9289 100 0.07 Contact Map
4bnqA 2 0.8426 99.8 0.699 Contact Map
3tquA 2 0.8477 99.6 0.75 Contact Map
1k7kA 1 0.8274 97.8 0.868 Contact Map
1b78A 2 0.8122 97.4 0.877 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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