GREMLIN Database
UBII - 2-octaprenylphenol hydroxylase
UniProt: P25535 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11333
Length: 400 (343)
Sequences: 26807 (20411)
Seq/√Len: 1102.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
30_A130_L4.2641.00
34_Q134_E3.6211.00
14_V305_G3.6021.00
7_A157_A3.5031.00
5_D28_R3.4691.00
5_D158_R3.2841.00
336_E340_K3.0781.00
137_Q173_K2.7091.00
134_E150_K2.7081.00
32_L155_L2.6351.00
120_K123_Q2.6231.00
18_V161_I2.5991.00
146_F154_M2.5111.00
133_A151_D2.5001.00
21_G313_I2.4451.00
69_D119_N2.4071.00
7_A32_L2.4051.00
25_S317_K2.3971.00
137_Q148_T2.3781.00
115_Y119_N2.3551.00
139_A146_F2.3461.00
146_F156_T2.3391.00
7_A147_L2.2931.00
148_T154_M2.2931.00
17_A306_F2.1651.00
14_V287_V2.1471.00
162_G170_L2.1341.00
130_L133_A2.1261.00
136_Q150_K2.1111.00
62_T67_W2.0731.00
133_A149_L2.0121.00
241_S244_E1.9791.00
315_E338_S1.9621.00
6_V27_L1.9481.00
28_R128_T1.9331.00
139_A148_T1.9261.00
36_V132_P1.9201.00
247_R251_I1.9031.00
20_C120_K1.8731.00
69_D120_K1.8701.00
5_D30_A1.8631.00
141_G146_F1.8461.00
32_L149_L1.8261.00
162_G286_L1.8161.00
60_L310_A1.8111.00
280_A333_R1.8071.00
149_L155_L1.7831.00
340_K344_A1.7671.00
315_E334_R1.7611.00
309_A313_I1.7581.00
57_S303_N1.7501.00
278_Q281_S1.7481.00
6_V22_L1.7391.00
27_L317_K1.7151.00
163_A287_V1.7091.00
141_G144_E1.7061.00
135_L147_L1.6981.00
23_Q127_I1.6981.00
121_A127_I1.6961.00
140_W281_S1.6851.00
246_N250_N1.6741.00
141_G156_T1.6721.00
63_R310_A1.6651.00
68_Q72_S1.6611.00
69_D123_Q1.6201.00
164_D168_S1.6191.00
138_V160_V1.6111.00
327_G330_I1.5911.00
280_A285_A1.5841.00
30_A155_L1.5641.00
69_D72_S1.5621.00
311_E315_E1.5611.00
169_W173_K1.5551.00
118_W131_A1.5501.00
19_A31_V1.5421.00
7_A155_L1.5361.00
144_E156_T1.5181.00
20_C24_G1.5151.00
18_V309_A1.5091.00
244_E247_R1.4861.00
118_W122_H1.4511.00
174_A284_L1.4451.00
159_L332_L1.4411.00
311_E338_S1.4401.00
9_V135_L1.4361.00
90_G93_S1.4321.00
279_F343_A1.4241.00
263_E266_R1.4071.00
21_G64_L1.4061.00
67_W71_L1.4051.00
13_M302_V1.3971.00
278_Q336_E1.3961.00
285_A312_L1.3921.00
193_R262_V1.3911.00
243_D247_R1.3861.00
308_D339_R1.3831.00
307_M342_S1.3821.00
279_F336_E1.3511.00
85_D88_S1.3421.00
242_E246_N1.3311.00
161_I287_V1.3271.00
314_A338_S1.3201.00
315_E331_Y1.3201.00
169_W172_N1.3071.00
9_V164_D1.3071.00
273_G351_Q1.3051.00
8_I18_V1.2931.00
130_L155_L1.2901.00
20_C121_A1.2791.00
57_S306_F1.2781.00
247_R250_N1.2771.00
136_Q148_T1.2691.00
74_R112_V1.2681.00
135_L170_L1.2591.00
120_K125_S1.2581.00
119_N122_H1.2531.00
139_A154_M1.2491.00
18_V22_L1.2291.00
30_A128_T1.2241.00
292_H308_D1.2241.00
7_A30_A1.2121.00
135_L138_V1.2021.00
240_A244_E1.1951.00
315_E318_R1.1891.00
68_Q71_L1.1831.00
23_Q126_D1.1821.00
177_P277_R1.1791.00
253_F256_R1.1761.00
17_A64_L1.1751.00
31_V129_L1.1751.00
179_T277_R1.1741.00
9_V170_L1.1661.00
280_A336_E1.1601.00
193_R222_L1.1581.00
140_W283_R1.1571.00
286_L290_A1.1561.00
248_A252_A1.1511.00
5_D27_L1.1501.00
147_L157_A1.1481.00
51_S302_V1.1341.00
138_V173_K1.1331.00
161_I285_A1.1331.00
254_D257_L1.1251.00
166_A293_T1.1191.00
32_L130_L1.1171.00
133_A153_S1.1151.00
145_T283_R1.1091.00
140_W145_T1.1091.00
112_V115_Y1.1091.00
109_E112_V1.0991.00
248_A251_I1.0921.00
294_I304_L1.0911.00
18_V287_V1.0871.00
69_D116_A1.0821.00
11_G16_L1.0801.00
24_G120_K1.0791.00
8_I19_A1.0631.00
344_A348_A1.0621.00
157_A160_V1.0561.00
118_W129_L1.0501.00
58_E67_W1.0501.00
149_L152_G1.0451.00
63_R314_A1.0421.00
8_I29_V1.0291.00
287_V335_Y1.0291.00
89_F93_S1.0281.00
16_L121_A1.0201.00
19_A29_V1.0181.00
29_V127_I1.0101.00
280_A329_Y1.0051.00
119_N123_Q1.0051.00
245_F253_F1.0011.00
37_Q131_A0.9981.00
20_C125_S0.9951.00
32_L133_A0.9861.00
17_A21_G0.9781.00
9_V160_V0.9771.00
162_G284_L0.9771.00
333_R337_R0.9771.00
242_E266_R0.9721.00
334_R337_R0.9711.00
233_E236_R0.9681.00
294_I347_L0.9631.00
243_D246_N0.9631.00
66_V120_K0.9631.00
351_Q355_D0.9611.00
138_V174_A0.9581.00
135_L169_W0.9561.00
276_A286_L0.9471.00
135_L173_K0.9451.00
249_L253_F0.9451.00
311_E314_A0.9311.00
193_R261_K0.9311.00
240_A245_F0.9291.00
56_A307_M0.9251.00
13_M306_F0.9241.00
24_G125_S0.9241.00
244_E248_A0.9231.00
318_R334_R0.9181.00
20_C64_L0.9181.00
59_K62_T0.9151.00
51_S110_N0.9151.00
252_A256_R0.9141.00
285_A335_Y0.9111.00
30_A157_A0.9061.00
27_L320_H0.9011.00
116_A120_K0.9011.00
80_G201_V0.9001.00
16_L118_W0.8991.00
22_L27_L0.8981.00
274_R293_T0.8961.00
5_D157_A0.8941.00
70_I116_A0.8941.00
66_V116_A0.8911.00
70_I113_I0.8871.00
145_T160_V0.8861.00
280_A332_L0.8851.00
56_A300_Q0.8831.00
116_A119_N0.8791.00
38_E118_W0.8771.00
138_V170_L0.8731.00
170_L284_L0.8711.00
122_H128_T0.8701.00
245_F250_N0.8701.00
194_T197_P0.8671.00
176_I276_A0.8651.00
23_Q29_V0.8641.00
49_R110_N0.8631.00
11_G33_E0.8611.00
52_A105_G0.8571.00
21_G25_S0.8531.00
328_Q331_Y0.8501.00
147_L160_V0.8491.00
75_A106_H0.8491.00
33_E131_A0.8481.00
32_L157_A0.8471.00
223_C226_V0.8471.00
26_G29_V0.8461.00
58_E106_H0.8451.00
328_Q332_L0.8441.00
213_A226_V0.8431.00
48_L51_S0.8431.00
140_W282_H0.8421.00
286_L291_A0.8411.00
174_A281_S0.8401.00
176_I281_S0.8391.00
23_Q121_A0.8381.00
319_L334_R0.8371.00
80_G93_S0.8371.00
138_V284_L0.8321.00
329_Y333_R0.8261.00
62_T71_L0.8261.00
23_Q122_H0.8231.00
16_L114_H0.8141.00
279_F291_A0.8121.00
74_R115_Y0.8111.00
52_A107_I0.8091.00
249_L252_A0.8061.00
190_A225_I0.8031.00
56_A59_K0.8021.00
91_H94_F0.8001.00
313_I317_K0.7971.00
91_H95_D0.7961.00
89_F94_F0.7951.00
310_A314_A0.7901.00
255_N258_G0.7881.00
93_S96_D0.7861.00
334_R338_S0.7841.00
317_K321_R0.7831.00
294_I298_A0.7821.00
5_D155_L0.7781.00
22_L313_I0.7781.00
266_R269_F0.7761.00
203_R206_F0.7761.00
279_F340_K0.7751.00
77_C104_L0.7731.00
245_F249_L0.7631.00
21_G60_L0.7611.00
82_E201_V0.7601.00
114_H118_W0.7581.00
251_I254_D0.7581.00
23_Q128_T0.7571.00
159_L285_A0.7571.00
22_L316_L0.7561.00
110_N114_H0.7551.00
21_G24_G0.7551.00
122_H126_D0.7511.00
93_S97_Q0.7491.00
254_D258_G0.7491.00
19_A127_I0.7461.00
122_H127_I0.7451.00
161_I312_L0.7441.00
32_L147_L0.7441.00
121_A126_D0.7391.00
341_H345_L0.7381.00
175_D178_L0.7371.00
61_L66_V0.7351.00
61_L306_F0.7341.00
19_A121_A0.7321.00
202_A205_V0.7321.00
193_R220_P0.7311.00
112_V218_S0.7311.00
338_S341_H0.7261.00
298_A350_M0.7261.00
275_Y344_A0.7241.00
257_L260_C0.7191.00
187_A191_T0.7191.00
224_S228_S0.7191.00
281_S284_L0.7181.00
17_A117_L0.7161.00
130_L153_S0.7151.00
58_E62_T0.7141.00
201_V204_Q0.7121.00
162_G168_S0.7111.00
343_A347_L0.7101.00
253_F257_L0.7101.00
108_V113_I0.7091.00
276_A279_F0.7071.00
109_E218_S0.7051.00
293_T308_D0.7021.00
256_R259_L0.7011.00
18_V313_I0.7001.00
84_W203_R0.6951.00
271_L295_H0.6941.00
300_Q304_L0.6931.00
304_L346_M0.6921.00
69_D74_R0.6921.00
145_T149_L0.6891.00
60_L64_L0.6881.00
180_F183_Y0.6881.00
25_S313_I0.6871.00
302_V306_F0.6871.00
304_L343_A0.6861.00
275_Y279_F0.6861.00
121_A129_L0.6861.00
6_V159_L0.6851.00
194_T223_C0.6851.00
168_S171_R0.6831.00
89_F96_D0.6791.00
171_R286_L0.6791.00
188_L191_T0.6751.00
16_L31_V0.6741.00
134_E169_W0.6721.00
57_S60_L0.6711.00
319_L327_G0.6711.00
330_I334_R0.6701.00
140_W144_E0.6681.00
202_A206_F0.6671.00
282_H329_Y0.6671.00
224_S229_L0.6661.00
74_R116_A0.6651.00
21_G310_A0.6641.00
23_Q125_S0.6601.00
20_C23_Q0.6561.00
170_L173_K0.6551.00
29_V121_A0.6541.00
133_A150_K0.6531.00
253_F258_G0.6501.00
297_L354_R0.6501.00
56_A342_S0.6481.00
249_L259_L0.6471.00
250_N257_L0.6461.00
275_Y340_K0.6461.00
160_V284_L0.6451.00
84_W88_S0.6441.00
250_N255_N0.6421.00
302_V305_G0.6401.00
359_G362_P0.6381.00
159_L320_H0.6371.00
11_G31_V0.6341.00
54_N303_N0.6331.00
35_R45_P0.6311.00
294_I350_M0.6301.00
253_F259_L0.6291.00
240_A248_A0.6271.00
162_G169_W0.6251.00
178_L274_R0.6241.00
333_R336_E0.6231.00
17_A61_L0.6211.00
159_L316_L0.6211.00
135_L149_L0.6211.00
6_V18_V0.6211.00
187_A190_A0.6181.00
285_A332_L0.6181.00
162_G174_A0.6181.00
90_G94_F0.6171.00
246_N249_L0.6141.00
250_N254_D0.6131.00
353_F356_L0.6131.00
345_L348_A0.6121.00
230_S233_E0.6111.00
149_L153_S0.6091.00
287_V309_A0.6081.00
327_G331_Y0.6081.00
319_L331_Y0.6041.00
172_N177_P0.6011.00
300_Q303_N0.6011.00
20_C127_I0.6001.00
159_L328_Q0.6001.00
267_Q271_L0.5991.00
295_H298_A0.5971.00
38_E131_A0.5961.00
268_V271_L0.5951.00
74_R77_C0.5951.00
70_I106_H0.5931.00
241_S245_F0.5911.00
267_Q270_P0.5871.00
16_L129_L0.5861.00
28_R158_R0.5841.00
29_V126_D0.5821.00
314_A318_R0.5821.00
62_T103_H0.5821.00
337_R341_H0.5811.00
164_D286_L0.5811.00
186_H231_P0.5801.00
348_A352_G0.5801.00
352_G355_D0.5771.00
218_S222_L0.5761.00
59_K63_R0.5761.00
319_L330_I0.5741.00
67_W70_I0.5731.00
62_T68_Q0.5721.00
183_Y351_Q0.5701.00
53_I57_S0.5701.00
27_L321_R0.5691.00
307_M339_R0.5681.00
289_D305_G0.5671.00
351_Q354_R0.5651.00
292_H339_R0.5621.00
180_F274_R0.5621.00
191_T222_L0.5621.00
18_V163_A0.5621.00
250_N259_L0.5611.00
89_F92_I0.5591.00
215_L224_S0.5591.00
14_V161_I0.5581.00
29_V128_T0.5581.00
285_A336_E0.5561.00
61_L113_I0.5561.00
60_L63_R0.5561.00
176_I181_W0.5561.00
250_N256_R0.5551.00
225_I228_S0.5551.00
185_H189_V0.5551.00
185_H297_L0.5541.00
190_A194_T0.5531.00
271_L274_R0.5511.00
256_R260_C0.5511.00
91_H96_D0.5511.00
82_E91_H0.5501.00
211_I215_L0.5501.00
85_D89_F0.5491.00
37_Q45_P0.5471.00
249_L256_R0.5471.00
158_R283_R0.5451.00
311_E335_Y0.5451.00
184_Q189_V0.5451.00
219_D222_L0.5451.00
92_I96_D0.5441.00
20_C66_V0.5441.00
298_A353_F0.5441.00
10_G15_G0.5421.00
61_L70_I0.5411.00
158_R320_H0.5401.00
139_A142_E0.5391.00
18_V316_L0.5381.00
210_G217_L0.5371.00
330_I333_R0.5361.00
112_V116_A0.5361.00
167_N172_N0.5351.00
18_V21_G0.5341.00
213_A217_L0.5331.00
307_M311_E0.5331.00
90_G95_D0.5321.00
21_G309_A0.5301.00
160_V170_L0.5301.00
147_L155_L0.5301.00
315_E319_L0.5281.00
253_F260_C0.5271.00
109_E222_L0.5271.00
144_E158_R0.5271.00
345_L349_G0.5271.00
24_G63_R0.5271.00
305_G309_A0.5261.00
246_N257_L0.5251.00
36_V131_A0.5251.00
79_H200_A0.5241.00
160_V283_R0.5241.00
89_F95_D0.5241.00
96_D99_M0.5231.00
269_F272_T0.5201.00
91_H97_Q0.5201.00
54_N57_S0.5181.00
92_I95_D0.5181.00
352_G356_L0.5171.00
122_H131_A0.5171.00
215_L218_S0.5171.00
94_F97_Q0.5171.00
186_H189_V0.5151.00
11_G129_L0.5121.00
176_I183_Y0.5101.00
186_H268_V0.5081.00
335_Y339_R0.5071.00
217_L220_P0.5071.00
225_I229_L0.5061.00
164_D171_R0.5041.00
74_R108_V0.5041.00
229_L233_E0.5031.00
254_D259_L0.5021.00
132_P151_D0.5011.00
287_V305_G0.5011.00
186_H190_A0.5011.00
252_A257_L0.5001.00
222_L225_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4n9xA 5 0.9275 100 0.25 Contact Map
2qa1A 2 0.9325 100 0.292 Contact Map
2qa2A 2 0.9425 100 0.295 Contact Map
4k22A 4 0.89 100 0.302 Contact Map
4k5sA 2 0.945 100 0.303 Contact Map
1pn0A 3 0.96 100 0.307 Contact Map
4k2xA 2 0.93 100 0.319 Contact Map
2x3nA 1 0.875 100 0.325 Contact Map
2dkhA 2 0.9025 100 0.327 Contact Map
1k0iA 2 0.955 100 0.328 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.012 seconds.