GREMLIN Database
UBIH - 2-octaprenyl-6-methoxyphenol hydroxylase
UniProt: P25534 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11324
Length: 392 (338)
Sequences: 26967 (20414)
Seq/√Len: 1110.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
30_H128_H4.3451.00
4_I155_G3.5471.00
34_A132_R3.4441.00
11_A302_G3.2391.00
2_S28_P2.9481.00
333_Q337_Q2.8251.00
144_E152_T2.6971.00
118_L121_K2.6761.00
32_I153_L2.6351.00
15_L159_V2.6321.00
2_S156_R2.6151.00
25_G314_T2.5641.00
135_N171_A2.5561.00
131_D149_S2.5471.00
135_N146_T2.5241.00
18_A310_A2.4461.00
144_E154_T2.3691.00
137_A144_E2.3651.00
132_R148_E2.3451.00
113_Q117_A2.3181.00
11_A284_V2.2621.00
146_T152_T2.2401.00
68_S117_A2.2251.00
4_I32_I2.2181.00
160_A168_L2.1811.00
4_I145_V2.1741.00
131_D151_E2.1551.00
61_A66_W2.1061.00
14_T303_M2.0891.00
128_H131_D2.0821.00
36_A130_P2.0481.00
68_S118_L2.0461.00
312_T335_R1.9911.00
139_T144_E1.9241.00
17_L118_L1.9231.00
312_T331_R1.9221.00
238_S241_K1.9141.00
134_A148_E1.9091.00
244_R248_S1.8641.00
118_L122_A1.8641.00
137_A146_T1.8571.00
337_Q341_E1.8131.00
131_D147_L1.7811.00
27_L314_T1.7641.00
62_R307_M1.7551.00
59_Q307_M1.7391.00
28_P126_T1.7221.00
243_C247_Q1.7131.00
167_A171_A1.7011.00
139_T154_T1.6911.00
147_L153_L1.6881.00
139_T142_H1.6831.00
56_T300_N1.6581.00
275_R278_T1.6501.00
20_S125_V1.6491.00
306_V310_A1.6481.00
116_F129_C1.6391.00
136_V158_L1.6341.00
32_I147_L1.6331.00
142_H154_T1.6281.00
160_A283_L1.6271.00
17_L21_R1.6201.00
16_A31_L1.6141.00
138_R278_T1.6091.00
308_S335_R1.5971.00
161_A284_V1.5951.00
68_S71_D1.5951.00
116_F120_R1.5821.00
68_S121_K1.5691.00
277_I330_C1.5671.00
30_H153_L1.5581.00
308_S312_T1.5441.00
277_I282_V1.5301.00
119_L125_V1.5291.00
147_L151_E1.5291.00
133_V145_V1.5241.00
275_R333_Q1.5141.00
20_S122_A1.5111.00
21_R122_A1.5081.00
2_S30_H1.5081.00
128_H151_E1.5041.00
324_G327_G1.4901.00
3_V19_I1.4831.00
257_I260_A1.4741.00
15_L306_V1.4741.00
6_V133_V1.4601.00
67_Q71_D1.4541.00
66_W70_A1.4461.00
30_H126_T1.4451.00
172_C281_T1.4391.00
162_D166_S1.4321.00
88_G91_T1.4291.00
72_C110_N1.4251.00
241_K244_R1.4201.00
18_A63_I1.4031.00
4_I153_L1.3811.00
282_V309_L1.3481.00
134_A146_T1.3431.00
276_S340_R1.3381.00
6_V162_D1.3201.00
147_L150_G1.3151.00
133_V136_V1.3101.00
128_H153_L1.3061.00
167_A170_T1.3011.00
312_T328_V1.2991.00
157_V329_L1.2911.00
5_I15_L1.2861.00
10_M299_F1.2701.00
312_T315_Q1.2451.00
68_S114_R1.2421.00
136_V171_A1.2371.00
276_S333_Q1.2361.00
277_I333_Q1.2341.00
244_R247_Q1.2251.00
137_A152_T1.2201.00
239_D243_C1.2141.00
3_V27_L1.2131.00
83_D86_H1.2131.00
237_W241_K1.2121.00
14_T63_I1.2111.00
38_E129_C1.2081.00
304_R339_D1.2071.00
305_D336_R1.2051.00
17_L122_A1.2011.00
56_T303_M1.1971.00
164_T290_T1.1831.00
107_E110_N1.1821.00
67_Q70_A1.1821.00
159_V282_V1.1791.00
311_E335_R1.1751.00
145_V155_G1.1741.00
110_N113_Q1.1651.00
270_L348_D1.1641.00
240_E244_R1.1631.00
245_E249_A1.1621.00
191_A219_R1.1571.00
31_L127_L1.1541.00
159_V284_V1.1511.00
17_L119_L1.1421.00
117_A120_R1.1421.00
138_R280_R1.1341.00
83_D87_A1.1201.00
6_V168_L1.1201.00
114_R117_A1.1161.00
57_C66_W1.1131.00
16_A29_V1.1101.00
248_S251_G1.1081.00
4_I30_H1.1061.00
32_I128_H1.0981.00
15_L19_I1.0951.00
283_L287_A1.0941.00
341_E345_G1.0871.00
263_R266_Y1.0791.00
138_R143_V1.0781.00
245_E248_S1.0781.00
15_L284_V1.0771.00
143_V147_L1.0741.00
5_I16_A1.0691.00
72_C113_Q1.0661.00
230_R233_E1.0591.00
177_Q274_A1.0551.00
289_Q305_D1.0501.00
175_D274_A1.0481.00
291_L301_L1.0461.00
37_P129_C1.0451.00
133_V168_L1.0351.00
20_S124_G1.0301.00
143_V280_R1.0261.00
78_T199_R1.0191.00
21_R118_L1.0171.00
330_C334_Q1.0091.00
116_F127_L1.0071.00
277_I326_Y1.0061.00
284_V332_Y1.0011.00
192_T195_A1.0001.00
6_V158_L1.0001.00
308_S311_E0.9931.00
30_H155_G0.9921.00
250_F253_R0.9881.00
20_S29_V0.9871.00
13_A119_L0.9851.00
221_S225_C0.9851.00
38_E116_F0.9811.00
307_M311_E0.9741.00
32_I131_D0.9631.00
89_F92_L0.9591.00
348_D352_H0.9551.00
117_A121_K0.9541.00
114_R118_L0.9521.00
8_G13_A0.9521.00
326_Y330_C0.9481.00
29_V125_V0.9471.00
65_V118_L0.9441.00
136_V172_C0.9411.00
14_T18_A0.9411.00
251_G254_L0.9401.00
268_L271_T0.9381.00
273_A283_L0.9301.00
133_V167_A0.9291.00
155_G158_L0.9291.00
233_E236_S0.9281.00
266_Y271_T0.9231.00
62_R311_E0.9231.00
2_S27_L0.9201.00
69_L111_V0.9141.00
50_I299_F0.9121.00
241_K245_E0.9111.00
27_L317_Q0.9091.00
68_S72_C0.9081.00
5_I29_V0.9041.00
291_L344_I0.9041.00
72_C114_R0.9041.00
17_L63_I0.9021.00
57_C104_Q0.9011.00
240_E243_C0.8991.00
8_G33_E0.8991.00
122_A125_V0.8991.00
65_V114_R0.8971.00
331_R334_Q0.8951.00
168_L281_T0.8941.00
266_Y269_A0.8921.00
73_A104_Q0.8891.00
18_A25_G0.8881.00
58_Q61_A0.8741.00
69_L114_R0.8701.00
89_F93_A0.8701.00
19_I27_L0.8661.00
133_V171_A0.8641.00
191_A258_T0.8611.00
136_V168_L0.8581.00
315_Q331_R0.8561.00
239_D263_R0.8531.00
13_A116_F0.8521.00
143_V158_L0.8501.00
278_T281_T0.8461.00
310_A314_T0.8441.00
325_D328_V0.8431.00
10_M303_M0.8421.00
145_V158_L0.8401.00
26_A29_V0.8341.00
272_H341_E0.8341.00
276_S288_A0.8271.00
282_V332_Y0.8271.00
19_I310_A0.8271.00
211_A223_V0.8261.00
325_D329_L0.8201.00
32_I155_G0.8181.00
20_S119_L0.8161.00
16_A119_L0.8141.00
91_T94_A0.8131.00
331_R335_R0.8131.00
338_S342_A0.8121.00
50_I108_L0.8101.00
120_R126_T0.8101.00
237_W242_F0.8101.00
138_R279_H0.8031.00
136_V281_T0.8011.00
271_T290_T0.7991.00
57_C61_A0.7951.00
191_A218_G0.7941.00
283_L288_A0.7941.00
18_A59_Q0.7941.00
19_I313_L0.7911.00
157_V282_V0.7901.00
194_V197_E0.7891.00
18_A21_R0.7881.00
160_A281_T0.7861.00
77_T198_G0.7861.00
119_L124_G0.7841.00
8_G31_L0.7841.00
316_A331_R0.7831.00
106_V111_V0.7781.00
51_A103_G0.7781.00
144_E147_L0.7731.00
55_G304_R0.7691.00
131_D148_E0.7681.00
107_E216_S0.7661.00
80_H199_R0.7651.00
277_I329_L0.7621.00
186_V189_N0.7621.00
185_A188_A0.7611.00
266_Y270_L0.7581.00
20_S120_R0.7551.00
61_A70_A0.7551.00
279_H326_Y0.7511.00
112_G116_F0.7491.00
199_R202_E0.7471.00
32_I145_V0.7451.00
185_A189_N0.7441.00
273_A276_S0.7421.00
191_A259_H0.7401.00
295_A347_T0.7401.00
55_G297_Q0.7391.00
174_V278_T0.7381.00
159_V309_L0.7371.00
13_A112_G0.7371.00
252_W255_G0.7361.00
201_F204_F0.7341.00
192_T220_C0.7341.00
250_F255_G0.7331.00
21_R25_G0.7331.00
2_S153_L0.7311.00
55_G58_Q0.7311.00
25_G310_A0.7301.00
184_L187_I0.7271.00
60_L303_M0.7241.00
327_G331_R0.7241.00
132_R167_A0.7221.00
335_R338_S0.7201.00
75_A102_L0.7151.00
242_F250_F0.7141.00
2_S155_G0.7131.00
119_L127_L0.7131.00
192_T196_H0.7121.00
174_V273_A0.7101.00
237_W245_E0.7091.00
272_H276_S0.7081.00
166_S169_A0.7071.00
222_L225_C0.7071.00
246_L250_F0.7051.00
340_R344_I0.7011.00
345_G349_S0.7011.00
59_Q62_R0.7001.00
82_S201_F0.7001.00
119_L122_A0.6981.00
76_I81_V0.6971.00
242_F247_Q0.6961.00
18_A307_M0.6901.00
88_G92_L0.6901.00
316_A324_G0.6891.00
253_R256_K0.6891.00
172_C278_T0.6891.00
91_T95_E0.6861.00
238_S242_F0.6791.00
264_S268_L0.6771.00
276_S337_Q0.6771.00
84_R87_A0.6741.00
33_E129_C0.6741.00
290_T305_D0.6731.00
20_S25_G0.6681.00
20_S126_T0.6661.00
181_Y348_D0.6651.00
14_T60_L0.6641.00
16_A125_V0.6641.00
282_V329_L0.6621.00
14_T115_L0.6621.00
191_A194_V0.6621.00
247_Q252_W0.6581.00
330_C333_Q0.6571.00
324_G328_V0.6561.00
247_Q251_G0.6551.00
173_G176_W0.6551.00
268_L292_H0.6541.00
80_H83_D0.6541.00
15_L310_A0.6541.00
221_S226_H0.6541.00
157_V313_L0.6521.00
60_L65_V0.6521.00
291_L295_A0.6511.00
265_A268_L0.6491.00
198_G201_F0.6471.00
17_L20_S0.6471.00
78_T91_T0.6461.00
342_A345_G0.6421.00
249_A253_R0.6411.00
220_C223_V0.6391.00
264_S267_P0.6381.00
52_L56_T0.6381.00
59_Q63_I0.6371.00
36_A129_C0.6371.00
200_A204_F0.6311.00
17_L125_V0.6291.00
316_A327_G0.6281.00
110_N216_S0.6251.00
56_T59_Q0.6251.00
284_V306_V0.6251.00
205_T208_G0.6251.00
21_R64_G0.6241.00
242_F246_L0.6201.00
200_A203_R0.6201.00
301_L340_R0.6201.00
233_E237_W0.6171.00
304_R308_S0.6141.00
222_L226_H0.6141.00
158_L281_T0.6111.00
267_P270_L0.6111.00
53_A300_N0.6111.00
29_V119_L0.6101.00
301_L343_T0.6081.00
11_A159_V0.6081.00
51_A105_V0.6081.00
262_K266_Y0.6071.00
234_V238_S0.6051.00
350_L353_L0.6051.00
183_Q187_I0.6051.00
130_P148_E0.6021.00
247_Q256_K0.6001.00
312_T316_A0.5961.00
184_L228_L0.5961.00
291_L347_T0.5951.00
295_A350_L0.5951.00
29_V124_G0.5941.00
316_A328_V0.5941.00
47_G50_I0.5941.00
160_A167_A0.5941.00
294_I351_V0.5911.00
80_H201_F0.5911.00
13_A31_L0.5911.00
299_F303_M0.5891.00
168_L171_A0.5881.00
89_F94_A0.5881.00
311_E315_Q0.5831.00
35_T39_S0.5831.00
188_A192_T0.5821.00
110_N114_R0.5811.00
108_L112_G0.5801.00
60_L69_L0.5791.00
107_E219_R0.5791.00
234_V237_W0.5781.00
160_A172_C0.5771.00
342_A346_V0.5761.00
247_Q254_L0.5761.00
243_C246_L0.5721.00
297_Q301_L0.5721.00
181_Y185_A0.5711.00
251_G255_G0.5711.00
260_A263_R0.5691.00
216_S219_R0.5681.00
188_A222_L0.5671.00
138_R142_H0.5651.00
215_M219_R0.5621.00
61_A101_A0.5611.00
39_S46_D0.5571.00
249_A252_W0.5561.00
173_G178_Q0.5561.00
80_H89_F0.5561.00
13_A127_L0.5561.00
38_E113_Q0.5551.00
76_I79_V0.5551.00
82_S87_A0.5531.00
184_L188_A0.5531.00
327_G330_C0.5531.00
60_L111_V0.5521.00
158_L168_L0.5521.00
236_S239_D0.5511.00
120_R129_C0.5511.00
243_C249_A0.5501.00
349_S352_H0.5501.00
239_D242_F0.5501.00
242_F245_E0.5491.00
66_W69_L0.5491.00
27_L313_L0.5471.00
157_V317_Q0.5471.00
69_L104_Q0.5461.00
176_W271_T0.5451.00
183_Q294_I0.5451.00
54_A58_Q0.5441.00
247_Q253_R0.5431.00
187_I190_V0.5431.00
272_H337_Q0.5421.00
88_G94_A0.5401.00
299_F302_G0.5401.00
187_I191_A0.5391.00
181_Y186_V0.5381.00
165_H170_T0.5371.00
181_Y187_I0.5371.00
226_H230_R0.5361.00
58_Q62_R0.5351.00
156_R317_Q0.5351.00
157_V325_D0.5331.00
76_I105_V0.5331.00
160_A287_A0.5321.00
352_H356_N0.5311.00
38_E112_G0.5311.00
64_G67_Q0.5311.00
250_F256_K0.5301.00
169_A283_L0.5291.00
282_V333_Q0.5281.00
142_H156_R0.5261.00
156_R280_R0.5261.00
72_C106_V0.5251.00
90_V93_A0.5231.00
180_P269_A0.5231.00
160_A166_S0.5221.00
252_W256_K0.5221.00
345_G348_D0.5211.00
289_Q340_R0.5201.00
286_N302_G0.5201.00
15_L18_A0.5181.00
247_Q250_F0.5181.00
332_Y336_R0.5181.00
93_A96_D0.5151.00
80_H91_T0.5141.00
180_P184_L0.5131.00
182_E187_I0.5131.00
261_G264_S0.5081.00
191_A261_G0.5081.00
308_S336_R0.5081.00
145_V153_L0.5071.00
313_L317_Q0.5071.00
18_A306_V0.5061.00
46_D50_I0.5031.00
184_L265_A0.5021.00
302_G306_V0.5021.00
174_V177_Q0.5021.00
74_T77_T0.5011.00
346_V349_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4n9xA 5 0.926 100 0.243 Contact Map
2qa1A 2 0.9311 100 0.276 Contact Map
2qa2A 2 0.9439 100 0.28 Contact Map
4k5sA 2 0.9439 100 0.291 Contact Map
1pn0A 3 0.9617 100 0.298 Contact Map
4k22A 4 0.8929 100 0.3 Contact Map
2x3nA 1 0.8852 100 0.308 Contact Map
4k2xA 2 0.9362 100 0.308 Contact Map
1k0iA 2 0.9617 100 0.314 Contact Map
2dkhA 2 0.898 100 0.315 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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