GREMLIN Database
YICR - UPF0758 protein YicR
UniProt: P25531 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11312
Length: 222 (218)
Sequences: 3149 (2321)
Seq/√Len: 157.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_K47_E5.3001.00
52_F61_S3.1151.00
214_V219_R2.9801.00
129_D133_R2.9451.00
138_R158_E2.9411.00
156_I195_C2.7061.00
192_I202_V2.6931.00
169_L202_V2.6841.00
111_L170_A2.6391.00
185_K216_F2.6301.00
136_T162_I2.4301.00
101_L134_V2.2201.00
126_I134_V2.2151.00
182_K186_L2.0951.00
43_T46_K2.0951.00
120_R142_S2.0941.00
102_L106_M2.0771.00
62_E65_Q2.0711.00
130_S146_N2.0071.00
169_L191_I1.9921.00
178_A212_E1.9861.00
40_D43_T1.9641.00
124_M139_R1.9431.00
105_E109_E1.9091.00
54_S57_G1.8591.00
145_L165_S1.8521.00
189_E193_K1.8411.00
139_R142_S1.8311.00
122_I142_S1.7801.00
114_Q137_H1.7701.00
118_E122_I1.7591.00
25_V46_K1.7411.00
123_F150_V1.7361.00
115_L118_E1.7321.00
107_T168_I1.6771.00
108_R112_Q1.6551.00
122_I139_R1.6411.00
120_R141_F1.6381.00
193_K196_Q1.6371.00
155_I191_I1.6281.00
132_H166_A1.6141.00
127_F158_E1.5921.00
157_R163_N1.5911.00
192_I196_Q1.5881.00
185_K221_W1.5741.00
83_I87_A1.5691.00
104_P218_E1.5411.00
72_I77_F1.5261.00
14_M19_I1.5201.00
159_A200_L1.5191.00
141_F148_V1.5171.00
124_M137_H1.5161.00
127_F162_I1.5041.00
131_Q177_C1.4551.00
38_G70_H1.4481.00
67_S74_V1.4351.00
158_E161_K1.3901.00
123_F202_V1.3761.00
14_M78_A1.3451.00
29_A42_L1.3381.00
150_V187_I1.3371.00
63_Y67_S1.3341.00
66_F77_F1.3301.00
158_E162_I1.3271.00
127_F138_R1.3251.00
14_M22_L1.3041.00
11_R75_A1.3041.00
156_I198_M1.3031.00
33_R79_Q1.2911.00
17_F21_A1.2881.00
41_V45_A1.2731.00
216_F221_W1.2591.00
55_L86_L1.2561.00
31_F79_Q1.2511.00
188_T205_H1.2461.00
51_N69_V1.2451.00
14_M30_L1.2311.00
51_N68_G1.2261.00
123_F148_V1.2211.00
6_Q9_M1.2091.00
115_L124_M1.2081.00
116_T210_R1.2021.00
67_S77_F1.2011.00
13_K26_E1.1801.00
214_V221_W1.1691.00
182_K185_K1.1431.00
194_S197_F1.1421.00
128_L166_A1.1361.00
144_T149_E1.1301.00
112_Q116_T1.1291.00
132_H203_L1.1271.00
25_V42_L1.1231.00
178_A214_V1.1161.00
159_A167_L1.1131.00
101_L107_T1.1061.00
13_K17_F1.0990.99
126_I137_H1.0980.99
195_C198_M1.0960.99
189_E192_I1.0780.99
15_L74_V1.0760.99
206_I213_Y1.0740.99
31_F83_I1.0700.99
144_T151_H1.0650.99
32_L41_V1.0640.99
127_F159_A1.0640.99
148_V187_I1.0610.99
194_S198_M1.0570.99
179_E219_R1.0530.99
108_R213_Y1.0450.99
48_M69_V1.0440.99
101_L106_M1.0410.99
35_G76_K1.0270.99
34_T79_Q1.0200.99
116_T209_G1.0160.99
107_T206_I0.9990.99
103_S106_M0.9920.99
105_E218_E0.9840.99
110_F137_H0.9810.99
207_V214_V0.9780.99
178_A209_G0.9730.99
108_R218_E0.9680.99
141_F149_E0.9610.99
157_R161_K0.9600.99
63_Y74_V0.9530.99
144_T154_E0.9500.99
85_E89_R0.9470.98
15_L78_A0.9450.98
112_Q211_G0.9430.98
195_C202_V0.9360.98
145_L153_R0.9340.98
123_F187_I0.9280.98
34_T76_K0.9140.98
65_Q161_K0.9120.98
150_V155_I0.9120.98
72_I76_K0.9040.98
74_V78_A0.9020.98
111_L126_I0.8990.98
39_K43_T0.8990.98
20_S88_R0.8940.98
118_E139_R0.8890.98
63_Y81_K0.8820.98
9_M41_V0.8810.98
125_V169_L0.8690.97
136_T158_E0.8660.97
101_L110_F0.8660.97
209_G212_E0.8590.97
120_R138_R0.8580.97
119_E157_R0.8580.97
130_S165_S0.8550.97
51_N65_Q0.8520.97
112_Q210_R0.8510.97
13_K19_I0.8460.97
127_F140_L0.8450.97
216_F219_R0.8440.97
42_L46_K0.8440.97
111_L137_H0.8430.97
138_R162_I0.8430.97
63_Y77_F0.8360.97
10_P35_G0.8330.97
208_I213_Y0.8320.97
92_N114_Q0.8320.97
100_P133_R0.8250.96
204_D215_S0.8250.96
66_F80_L0.8240.96
166_A203_L0.8220.96
54_S93_V0.8200.96
63_Y78_A0.8170.96
84_A87_A0.8090.96
107_T170_A0.8030.96
167_L195_C0.8030.96
108_R206_I0.8010.96
114_Q124_M0.7980.96
178_A207_V0.7960.96
10_P33_R0.7950.96
75_A78_A0.7900.95
99_S134_V0.7880.95
213_Y218_E0.7850.95
154_E157_R0.7840.95
24_D93_V0.7820.95
65_Q68_G0.7770.95
123_F169_L0.7760.95
183_A186_L0.7710.95
30_L34_T0.7660.95
85_E88_R0.7610.94
5_S8_L0.7580.94
118_E142_S0.7560.94
10_P29_A0.7460.94
10_P30_L0.7400.93
98_E133_R0.7380.93
28_L153_R0.7370.93
77_F81_K0.7320.93
56_Y93_V0.7280.93
60_T90_Y0.7280.93
127_F164_A0.7260.93
99_S106_M0.7230.93
120_R154_E0.7100.92
193_K197_F0.7070.92
185_K189_E0.7070.92
186_L189_E0.7020.92
35_G79_Q0.6980.91
156_I202_V0.6970.91
24_D89_R0.6940.91
143_G172_N0.6920.91
79_Q83_I0.6900.91
125_V140_L0.6890.91
106_M134_V0.6890.91
104_P108_R0.6850.91
29_A33_R0.6750.90
135_I164_A0.6720.90
59_L84_A0.6720.90
173_H184_D0.6720.90
190_R199_D0.6700.90
145_L163_N0.6680.89
4_N42_L0.6670.89
91_Y113_S0.6650.89
60_T119_E0.6610.89
173_H181_S0.6590.89
207_V221_W0.6590.89
115_L208_I0.6540.88
4_N46_K0.6540.88
140_L155_I0.6520.88
207_V216_F0.6510.88
14_M81_K0.6490.88
121_E171_H0.6480.88
19_I30_L0.6460.88
114_Q139_R0.6450.88
25_V41_V0.6420.88
186_L190_R0.6390.87
47_E51_N0.6380.87
109_E112_Q0.6370.87
22_L26_E0.6330.87
121_E173_H0.6320.87
111_L206_I0.6310.87
36_T39_K0.6300.87
6_Q16_K0.6290.86
155_I167_L0.6180.85
14_M85_E0.6170.85
155_I169_L0.6150.85
66_F72_I0.6140.85
123_F152_P0.6130.85
171_H181_S0.6100.85
151_H154_E0.6070.84
146_N165_S0.6050.84
180_P214_V0.6010.84
128_L168_I0.5970.83
185_K214_V0.5960.83
57_G93_V0.5960.83
40_D46_K0.5950.83
125_V167_L0.5950.83
181_S184_D0.5930.83
118_E124_M0.5900.83
84_A90_Y0.5900.83
212_E219_R0.5900.83
121_E181_S0.5900.83
5_S9_M0.5890.83
44_L47_E0.5850.82
52_F69_V0.5830.82
113_S116_T0.5830.82
107_T126_I0.5810.82
95_M109_E0.5810.82
153_R165_S0.5800.82
13_K23_T0.5780.81
32_L44_L0.5770.81
10_P41_V0.5770.81
29_A35_G0.5760.81
167_L202_V0.5730.81
172_N184_D0.5720.81
48_M72_I0.5720.81
57_G60_T0.5700.81
73_G76_K0.5670.80
9_M40_D0.5650.80
121_E174_P0.5640.80
131_Q175_S0.5630.80
30_L41_V0.5620.80
143_G173_H0.5620.80
36_T70_H0.5620.80
190_R194_S0.5600.79
60_T84_A0.5600.79
154_E175_S0.5590.79
87_A90_Y0.5570.79
145_L151_H0.5560.79
39_K44_L0.5550.79
20_S85_E0.5530.79
181_S188_T0.5520.78
64_E162_I0.5520.78
121_E143_G0.5510.78
160_I194_S0.5490.78
127_F167_L0.5480.78
195_C200_L0.5470.78
19_I22_L0.5450.78
29_A76_K0.5440.77
19_I27_L0.5430.77
39_K70_H0.5420.77
11_R14_M0.5420.77
157_R160_I0.5420.77
12_E16_K0.5400.77
186_L193_K0.5400.77
27_L86_L0.5370.77
143_G184_D0.5360.76
59_L90_Y0.5330.76
56_Y117_G0.5330.76
145_L152_P0.5330.76
10_P76_K0.5320.76
190_R193_K0.5320.76
56_Y60_T0.5320.76
9_M42_L0.5310.76
201_R217_A0.5310.76
90_Y117_G0.5300.76
15_L63_Y0.5270.75
207_V219_R0.5270.75
166_A201_R0.5240.75
104_P217_A0.5220.75
48_M58_L0.5200.74
33_R41_V0.5190.74
69_V72_I0.5180.74
130_S145_L0.5180.74
51_N70_H0.5150.74
134_V149_E0.5140.73
30_L82_G0.5130.73
143_G171_H0.5130.73
13_K42_L0.5080.73
196_Q201_R0.5050.72
53_G57_G0.5050.72
27_L35_G0.5030.72
30_L33_R0.5030.72
128_L132_H0.5020.72
185_K201_R0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qlcA 1 0.5676 100 0.421 Contact Map
1x2iA 2 0.3063 98.6 0.853 Contact Map
3c1yA 5 0.4054 98 0.877 Contact Map
1dgsA 1 0.473 97.1 0.896 Contact Map
4bxoA 1 0.3694 97 0.897 Contact Map
2owoA 1 0.473 96.8 0.9 Contact Map
2a1jB 2 0.3514 96.7 0.902 Contact Map
2bgwA 2 0.3784 96.6 0.903 Contact Map
1z00A 1 0.3784 96.5 0.903 Contact Map
1kftA 1 0.2523 96.3 0.906 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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