GREMLIN Database
GABP - GABA permease
UniProt: P25527 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11330
Length: 466 (422)
Sequences: 24885 (16073)
Seq/√Len: 782.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
138_T342_T4.3051.00
324_V336_V4.2671.00
384_R388_I3.4061.00
55_G246_S3.1901.00
376_L411_I3.1751.00
327_K336_V3.0651.00
232_K236_R3.0021.00
15_K228_D2.8571.00
227_S233_H2.6791.00
79_S318_R2.6461.00
95_G315_L2.6171.00
229_T232_K2.5831.00
316_S326_G2.5491.00
170_G255_V2.5381.00
329_N335_Y2.5261.00
131_L346_F2.4921.00
20_T240_S2.4461.00
324_V327_K2.4281.00
16_S240_S2.4051.00
168_F172_V2.2791.00
225_A317_R2.2651.00
284_H288_I2.2371.00
379_A410_V2.2321.00
442_I446_P2.2031.00
226_E310_R2.1671.00
67_E386_R2.1661.00
83_D91_G2.1561.00
139_G143_L2.1481.00
339_L343_G2.1341.00
16_S233_H2.1181.00
19_V227_S2.1081.00
313_Y317_R2.1071.00
275_S278_E2.0921.00
16_S20_T2.0671.00
135_L346_F2.0581.00
146_K150_E2.0491.00
138_T338_V2.0341.00
142_L335_Y2.0111.00
236_R240_S2.0091.00
122_P125_P1.9571.00
86_I384_R1.9501.00
408_W412_G1.9071.00
319_G323_A1.9041.00
15_K18_H1.9001.00
130_S349_V1.9001.00
83_D88_R1.8991.00
64_M379_A1.8991.00
437_L441_I1.8931.00
436_L440_G1.8851.00
325_M340_L1.8831.00
99_W341_S1.8801.00
131_L349_V1.8651.00
157_L161_I1.8641.00
39_A47_V1.8571.00
56_L60_M1.8441.00
10_L328_I1.8431.00
86_I380_V1.8341.00
441_I445_V1.7851.00
261_P264_M1.7571.00
405_W409_L1.7511.00
275_S279_L1.7491.00
440_G443_C1.7431.00
229_T233_H1.7331.00
57_L413_F1.7291.00
329_N333_T1.7241.00
239_N243_W1.7141.00
18_H153_F1.7071.00
380_V411_I1.7051.00
264_M279_L1.7041.00
134_T345_A1.6711.00
82_A94_I1.6691.00
438_A442_I1.6691.00
444_T448_M1.6651.00
135_L342_T1.6581.00
142_L339_L1.6371.00
106_I345_A1.6281.00
20_T244_R1.6231.00
141_N302_N1.6181.00
23_S241_V1.6081.00
331_S335_Y1.6041.00
384_R387_K1.5981.00
412_G416_F1.5951.00
433_S436_L1.5941.00
161_I165_A1.5931.00
94_I377_V1.5921.00
110_A301_L1.5921.00
50_A206_A1.5831.00
434_T438_A1.5561.00
87_G90_A1.5551.00
14_L18_H1.5421.00
60_M409_L1.5311.00
117_L129_F1.5301.00
243_W247_I1.5061.00
440_G444_T1.4711.00
445_V449_A1.4671.00
269_A275_S1.4671.00
223_A306_Y1.4581.00
312_L337_A1.4541.00
54_A210_T1.4431.00
134_T342_T1.4401.00
56_L409_L1.4391.00
278_E286_K1.4391.00
336_V340_L1.4211.00
308_A341_S1.4201.00
143_L331_S1.4171.00
46_A196_M1.4091.00
313_Y328_I1.4001.00
229_T236_R1.3931.00
323_A326_G1.3861.00
162_A292_V1.3781.00
438_A441_I1.3741.00
171_A255_V1.3741.00
62_M242_I1.3721.00
82_A377_V1.3721.00
131_L135_L1.3711.00
309_S338_V1.3621.00
10_L313_Y1.3611.00
433_S440_G1.3591.00
383_L408_W1.3591.00
110_A134_T1.3551.00
380_V384_R1.3521.00
75_T225_A1.3431.00
327_K335_Y1.3331.00
11_G332_K1.3311.00
323_A327_K1.3291.00
138_T339_L1.3291.00
160_V164_L1.3201.00
72_T84_K1.3171.00
122_P126_I1.3141.00
48_L254_F1.3091.00
167_I251_C1.3001.00
287_L291_C1.2941.00
86_I90_A1.2931.00
443_C447_I1.2861.00
247_I251_C1.2781.00
18_H149_G1.2741.00
176_G179_P1.2711.00
16_S236_R1.2691.00
34_V112_I1.2681.00
113_A294_L1.2641.00
416_F420_V1.2631.00
230_P235_V1.2621.00
61_I379_A1.2611.00
62_M238_T1.2611.00
14_L19_V1.2581.00
233_H236_R1.2551.00
27_V245_I1.2531.00
71_A396_I1.2531.00
174_I258_A1.2521.00
89_W449_A1.2491.00
113_A133_I1.2451.00
435_G439_I1.2421.00
85_A381_S1.2351.00
434_T441_I1.2301.00
137_L301_L1.2241.00
376_L415_T1.2191.00
80_T84_K1.2141.00
435_G444_T1.1991.00
14_L149_G1.1981.00
312_L321_A1.1881.00
63_R239_N1.1831.00
271_G275_S1.1721.00
140_S151_F1.1681.00
64_M407_T1.1671.00
17_R21_M1.1661.00
433_S444_T1.1581.00
436_L441_I1.1551.00
402_L406_L1.1541.00
99_W312_L1.1491.00
166_F170_G1.1471.00
444_T447_I1.1411.00
40_I47_V1.1331.00
127_W131_L1.1321.00
109_E300_C1.1221.00
65_L78_F1.1201.00
262_W265_P1.1191.00
404_P408_W1.1171.00
278_E283_P1.1141.00
435_G438_A1.1081.00
228_D233_H1.1051.00
19_V237_A1.1051.00
74_D80_T1.1031.00
193_G197_P1.0951.00
405_W408_W1.0871.00
150_E154_W1.0851.00
46_A203_V1.0841.00
92_Y96_W1.0821.00
387_K404_P1.0791.00
152_E302_N1.0731.00
403_Y407_T1.0671.00
393_G396_I1.0671.00
23_S220_V1.0651.00
13_G228_D1.0591.00
392_E396_I1.0551.00
183_V186_I1.0541.00
82_A90_A1.0501.00
445_V448_M1.0491.00
165_A169_L1.0441.00
382_Q407_T1.0431.00
125_P128_L1.0411.00
444_T449_A1.0381.00
317_R326_G1.0371.00
151_F155_L1.0341.00
128_L132_V1.0341.00
438_A445_V1.0341.00
343_G347_L1.0311.00
434_T440_G1.0301.00
22_L223_A1.0301.00
171_A175_S1.0291.00
434_T437_L1.0251.00
170_G259_L1.0251.00
67_E70_V1.0231.00
79_S314_S1.0231.00
394_S397_R1.0201.00
69_A81_Y1.0191.00
379_A411_I1.0151.00
132_V136_A1.0141.00
328_I332_K1.0141.00
336_V339_L1.0121.00
114_A129_F1.0091.00
52_L250_L1.0071.00
204_L416_F1.0071.00
24_I245_I1.0061.00
24_I244_R1.0041.00
436_L444_T1.0021.00
434_T445_V0.9961.00
84_K391_A0.9961.00
138_T142_L0.9961.00
224_A234_I0.9931.00
135_L139_G0.9901.00
60_M406_L0.9881.00
145_V306_Y0.9871.00
199_G202_A0.9871.00
433_S441_I0.9831.00
411_I415_T0.9831.00
175_S179_P0.9821.00
439_I442_I0.9821.00
437_L444_T0.9791.00
435_G440_G0.9751.00
164_L168_F0.9751.00
117_L294_L0.9721.00
71_A394_S0.9721.00
438_A443_C0.9721.00
160_V248_F0.9711.00
402_L405_W0.9661.00
422_L426_A0.9651.00
74_D84_K0.9591.00
376_L414_I0.9571.00
167_I255_V0.9571.00
391_A394_S0.9551.00
283_P287_L0.9481.00
196_M203_V0.9481.00
172_V176_G0.9461.00
433_S437_L0.9401.00
166_F277_L0.9391.00
114_A130_S0.9371.00
415_T419_V0.9371.00
246_S250_L0.9351.00
218_E222_I0.9321.00
142_L333_T0.9311.00
395_E399_R0.9311.00
136_A298_T0.9281.00
137_L302_N0.9261.00
437_L440_G0.9231.00
281_N285_A0.9181.00
335_Y339_L0.9151.00
441_I444_T0.9151.00
21_M153_F0.9111.00
261_P279_L0.9111.00
175_S178_Y0.9111.00
215_M371_A0.9101.00
419_V423_F0.9081.00
48_L257_V0.9061.00
396_I399_R0.9041.00
240_S244_R0.9021.00
259_L276_V0.8991.00
76_G80_T0.8941.00
305_L342_T0.8881.00
117_L121_V0.8871.00
282_I285_A0.8851.00
442_I445_V0.8811.00
422_L425_P0.8801.00
55_G214_F0.8771.00
443_C446_P0.8761.00
437_L442_I0.8741.00
155_L299_S0.8701.00
42_E45_P0.8651.00
436_L439_I0.8611.00
52_L56_L0.8611.00
70_V397_R0.8591.00
159_K296_S0.8591.00
254_F258_A0.8571.00
61_I414_I0.8571.00
124_I128_L0.8561.00
329_N332_K0.8561.00
13_G146_K0.8541.00
434_T443_C0.8531.00
68_M382_Q0.8501.00
142_L329_N0.8501.00
10_L226_E0.8481.00
325_M336_V0.8471.00
436_L445_V0.8471.00
403_Y406_L0.8441.00
18_H150_E0.8431.00
418_L426_A0.8421.00
433_S438_A0.8411.00
83_D318_R0.8391.00
150_E153_F0.8391.00
108_L364_I0.8391.00
108_L212_F0.8381.00
28_I31_S0.8381.00
269_A272_S0.8381.00
435_G445_V0.8371.00
376_L380_V0.8321.00
446_P449_A0.8311.00
321_A325_M0.8311.00
418_L421_M0.8271.00
10_L310_R0.8261.00
342_T346_F0.8231.00
441_I449_A0.8221.00
172_V177_F0.8211.00
196_M199_G0.8161.00
129_F132_V0.8131.00
383_L407_T0.8111.00
123_G126_I0.8101.00
17_R153_F0.8101.00
82_A381_S0.8101.00
205_S209_I0.8071.00
200_F203_V0.8061.00
16_S237_A0.8061.00
59_V63_R0.8051.00
410_V414_I0.8051.00
395_E398_L0.8041.00
134_T349_V0.8041.00
167_I171_A0.8031.00
113_A298_T0.8031.00
264_M267_L0.7991.00
127_W349_V0.7981.00
76_G79_S0.7951.00
96_W321_A0.7921.00
219_I307_T0.7911.00
439_I443_C0.7871.00
438_A444_T0.7861.00
425_P428_Q0.7841.00
441_I446_P0.7821.00
113_A297_V0.7821.00
71_A397_R0.7811.00
98_Y102_W0.7801.00
90_A377_V0.7791.00
435_G441_I0.7771.00
277_L280_L0.7741.00
139_G142_L0.7711.00
49_L203_V0.7701.00
28_I159_K0.7701.00
383_L404_P0.7671.00
171_A251_C0.7661.00
215_M375_Y0.7661.00
111_N363_L0.7661.00
416_F419_V0.7651.00
59_V239_N0.7641.00
436_L443_C0.7621.00
137_L305_L0.7621.00
434_T442_I0.7601.00
60_M64_M0.7571.00
191_D194_G0.7551.00
89_W93_T0.7531.00
143_L147_N0.7421.00
417_V421_M0.7391.00
32_L252_S0.7351.00
186_I258_A0.7341.00
438_A448_M0.7331.00
20_T237_A0.7321.00
127_W130_S0.7241.00
229_T235_V0.7211.00
272_S276_V0.7201.00
174_I255_V0.7181.00
142_L331_S0.7141.00
79_S83_D0.7111.00
324_V340_L0.7091.00
330_R335_Y0.7081.00
383_L387_K0.7081.00
13_G145_V0.7071.00
310_R313_Y0.7061.00
366_S370_I0.7061.00
103_V344_A0.7041.00
235_V238_T0.7041.00
68_M81_Y0.7031.00
440_G445_V0.7021.00
114_A117_L0.7011.00
443_C449_A0.7001.00
149_G153_F0.6981.00
433_S442_I0.6981.00
271_G274_R0.6971.00
334_P337_A0.6971.00
85_A384_R0.6961.00
190_W193_G0.6961.00
105_V367_S0.6951.00
414_I417_V0.6951.00
439_I446_P0.6951.00
49_L53_F0.6911.00
381_S385_M0.6901.00
167_I252_S0.6891.00
64_M410_V0.6861.00
441_I447_I0.6851.00
424_R428_Q0.6841.00
107_P363_L0.6831.00
17_R150_E0.6831.00
402_L407_T0.6831.00
58_V217_A0.6801.00
131_L350_V0.6781.00
86_I381_S0.6771.00
305_L309_S0.6751.00
195_F198_N0.6751.00
172_V175_S0.6751.00
343_G346_F0.6731.00
141_N338_V0.6731.00
436_L449_A0.6731.00
435_G442_I0.6671.00
110_A114_A0.6661.00
382_Q386_R0.6661.00
75_T313_Y0.6651.00
28_I33_F0.6651.00
36_S253_I0.6641.00
398_L401_W0.6631.00
284_H287_L0.6621.00
137_L298_T0.6611.00
45_P257_V0.6611.00
25_A156_A0.6601.00
101_F371_A0.6591.00
325_M337_A0.6581.00
309_S337_A0.6571.00
105_V108_L0.6571.00
105_V109_E0.6561.00
46_A195_F0.6561.00
394_S399_R0.6551.00
60_M410_V0.6541.00
372_L414_I0.6531.00
410_V413_F0.6511.00
244_R248_F0.6501.00
135_L138_T0.6491.00
387_K391_A0.6491.00
10_L13_G0.6481.00
141_N306_Y0.6481.00
49_L52_L0.6471.00
29_G33_F0.6461.00
65_L378_I0.6451.00
437_L445_V0.6441.00
312_L340_L0.6441.00
87_G91_G0.6441.00
142_L338_V0.6401.00
439_I445_V0.6401.00
200_F204_L0.6391.00
13_G17_R0.6391.00
434_T439_I0.6391.00
85_A385_M0.6361.00
234_I238_T0.6361.00
204_L420_V0.6351.00
202_A205_S0.6351.00
96_W440_G0.6331.00
104_L366_S0.6321.00
69_A234_I0.6291.00
221_T238_T0.6291.00
414_I418_L0.6291.00
144_S147_N0.6281.00
117_L133_I0.6281.00
62_M217_A0.6271.00
53_F207_M0.6261.00
147_N150_E0.6251.00
316_S325_M0.6251.00
68_M85_A0.6241.00
27_V241_V0.6241.00
133_I301_L0.6221.00
396_I400_M0.6221.00
273_Y277_L0.6211.00
435_G449_A0.6211.00
272_S275_S0.6211.00
175_S183_V0.6201.00
120_W291_C0.6201.00
225_A313_Y0.6191.00
386_R403_Y0.6191.00
240_S243_W0.6191.00
158_C292_V0.6181.00
39_A43_A0.6181.00
134_T346_F0.6171.00
26_G303_S0.6141.00
436_L448_M0.6141.00
263_N267_L0.6141.00
169_L282_I0.6141.00
66_A70_V0.6141.00
48_L250_L0.6121.00
20_T23_S0.6111.00
48_L52_L0.6101.00
215_M218_E0.6101.00
370_I374_V0.6071.00
194_G197_P0.6071.00
35_G364_I0.6041.00
369_A418_L0.6031.00
78_F218_E0.6021.00
116_I293_I0.6011.00
434_T444_T0.6001.00
107_P348_T0.6001.00
193_G196_M0.6001.00
169_L173_A0.6001.00
47_V253_I0.6001.00
291_C295_L0.5991.00
79_S95_G0.5971.00
442_I449_A0.5961.00
231_E397_R0.5961.00
45_P48_L0.5951.00
296_S299_S0.5931.00
97_L374_V0.5931.00
433_S446_P0.5921.00
308_A312_L0.5911.00
401_W405_W0.5911.00
251_C255_V0.5911.00
102_W304_A0.5901.00
26_G304_A0.5891.00
222_I307_T0.5871.00
226_E334_P0.5861.00
433_S447_I0.5861.00
404_P407_T0.5841.00
244_R247_I0.5831.00
388_I391_A0.5831.00
28_I248_F0.5811.00
158_C162_A0.5811.00
71_A392_E0.5791.00
145_V223_A0.5791.00
24_I156_A0.5781.00
227_S234_I0.5781.00
48_L51_Y0.5761.00
156_A159_K0.5761.00
54_A214_F0.5751.00
69_A221_T0.5731.00
421_M425_P0.5721.00
38_V361_K0.5721.00
109_E112_I0.5701.00
423_F426_A0.5691.00
324_V328_I0.5691.00
54_A211_M0.5681.00
51_Y213_S0.5671.00
77_S221_T0.5651.00
394_S398_L0.5651.00
376_L418_L0.5641.00
192_S263_N0.5631.00
417_V422_L0.5631.00
79_S91_G0.5621.00
148_Y306_Y0.5621.00
78_F222_I0.5611.00
262_W266_G0.5601.00
419_V422_L0.5601.00
112_I116_I0.5591.00
440_G447_I0.5591.00
213_S249_Y0.5591.00
43_A46_A0.5581.00
407_T411_I0.5581.00
328_I331_S0.5581.00
38_V41_A0.5581.00
119_S290_D0.5581.00
438_A449_A0.5571.00
107_P110_A0.5561.00
138_T305_L0.5551.00
147_N151_F0.5551.00
39_A206_A0.5541.00
63_R406_L0.5531.00
103_V341_S0.5511.00
400_M403_Y0.5501.00
109_E297_V0.5481.00
230_P233_H0.5481.00
400_M406_L0.5461.00
272_S277_L0.5461.00
29_G249_Y0.5451.00
23_S27_V0.5441.00
63_R401_W0.5431.00
133_I137_L0.5431.00
252_S256_V0.5421.00
153_F157_L0.5421.00
109_E301_L0.5421.00
191_D195_F0.5401.00
383_L411_I0.5371.00
132_V135_L0.5371.00
62_M66_A0.5361.00
26_G219_I0.5361.00
152_E299_S0.5351.00
440_G449_A0.5351.00
371_A374_V0.5341.00
42_E205_S0.5341.00
412_G415_T0.5321.00
408_W411_I0.5321.00
38_V42_E0.5321.00
94_I374_V0.5311.00
17_R20_T0.5301.00
28_I35_G0.5301.00
149_G302_N0.5301.00
120_W290_D0.5281.00
397_R400_M0.5241.00
97_L101_F0.5241.00
255_V258_A0.5221.00
312_L316_S0.5221.00
392_E395_E0.5221.00
260_I264_M0.5211.00
420_V424_R0.5211.00
350_V353_Y0.5201.00
113_A117_L0.5201.00
154_W157_L0.5191.00
436_L447_I0.5171.00
283_P286_K0.5171.00
34_V37_S0.5161.00
288_I292_V0.5161.00
121_V124_I0.5151.00
227_S237_A0.5151.00
310_R334_P0.5141.00
110_A113_A0.5141.00
161_I164_L0.5141.00
39_A210_T0.5131.00
442_I447_I0.5121.00
36_S256_V0.5121.00
51_Y253_I0.5111.00
162_A288_I0.5111.00
347_L350_V0.5101.00
136_A140_S0.5091.00
252_S273_Y0.5091.00
153_F156_A0.5081.00
19_V223_A0.5071.00
335_Y338_V0.5071.00
361_K364_I0.5051.00
263_N266_G0.5051.00
67_E71_A0.5031.00
436_L446_P0.5031.00
51_Y249_Y0.5031.00
71_A385_M0.5021.00
61_I218_E0.5011.00
436_L442_I0.5011.00
46_A49_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.8948 100 0.297 Contact Map
4djkA 2 0.8906 100 0.332 Contact Map
3giaA 1 0.9142 100 0.338 Contact Map
3dh4A 3 0.9206 98.9 0.856 Contact Map
2xq2A 2 0.9227 98.9 0.856 Contact Map
2jlnA 1 0.8927 98.4 0.88 Contact Map
4wgvA 2 0.7918 97.7 0.898 Contact Map
4xp4A 1 0.9227 96.9 0.911 Contact Map
4us3A 1 0.8433 96.7 0.913 Contact Map
2a65A 2 0.927 96.5 0.915 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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