GREMLIN Database
GABD - Succinate-semialdehyde dehydrogenase [NADP(+)] GabD
UniProt: P25526 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11329
Length: 482 (453)
Sequences: 36502 (21854)
Seq/√Len: 1026.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
299_D398_K4.9811.00
243_E247_K3.9391.00
299_D396_R3.1561.00
271_D308_K3.1011.00
302_Y396_R2.9241.00
29_D41_S2.8101.00
359_K369_Q2.7821.00
58_N225_L2.7791.00
266_D298_Q2.7251.00
377_P380_A2.6681.00
334_E338_A2.6141.00
346_D381_K2.5841.00
275_E312_A2.5641.00
191_A194_E2.5511.00
345_A349_E2.5171.00
306_A394_L2.4761.00
266_D300_G2.4351.00
86_H89_D2.4021.00
84_M117_E2.3751.00
29_D38_K2.3241.00
420_A426_V2.3101.00
344_I368_F2.2261.00
58_N227_R2.2261.00
197_I203_A2.2011.00
46_G49_E2.1871.00
341_E345_A2.1371.00
87_Q110_S2.1291.00
88_D106_K2.1231.00
79_W196_A2.1161.00
82_L198_R2.0791.00
400_E425_R2.0611.00
346_D350_K2.0281.00
353_R375_D2.0241.00
411_E457_A2.0231.00
222_S244_Q2.0221.00
218_N222_S2.0051.00
184_Q333_D1.9821.00
145_Q476_K1.9811.00
341_E360_A1.9761.00
310_Q314_S1.9391.00
428_R432_A1.9261.00
331_L340_V1.9171.00
262_F277_A1.9091.00
341_E368_F1.9031.00
89_D191_A1.8981.00
304_R308_K1.8951.00
355_V374_V1.8731.00
75_I201_V1.8431.00
51_R219_E1.8351.00
240_Q243_E1.8221.00
348_L354_V1.8001.00
144_K470_E1.7981.00
267_D425_R1.7941.00
55_D225_L1.7931.00
239_R457_A1.7881.00
86_H198_R1.7581.00
82_L85_E1.7491.00
296_Y406_Q1.7491.00
434_E456_K1.7251.00
383_S395_F1.7241.00
144_K473_L1.7041.00
373_L382_V1.6961.00
400_E428_R1.6911.00
82_L199_A1.6881.00
51_R55_D1.6871.00
378_A406_Q1.6561.00
353_R374_V1.6501.00
298_Q397_F1.6471.00
38_K41_S1.6451.00
313_V372_I1.6251.00
402_D405_A1.6241.00
82_L195_L1.6211.00
310_Q355_V1.6161.00
296_Y403_V1.6111.00
193_A208_V1.6111.00
77_R117_E1.6021.00
93_L191_A1.5961.00
102_L106_K1.5761.00
398_K402_D1.5761.00
302_Y306_A1.5751.00
307_E311_Q1.5741.00
116_I168_G1.5621.00
84_M113_A1.5611.00
277_A305_F1.5581.00
68_T71_E1.5571.00
282_F313_V1.5561.00
212_S215_A1.5541.00
61_L65_R1.5521.00
51_R223_N1.5321.00
381_K385_E1.5311.00
342_E381_K1.5161.00
308_K311_Q1.5161.00
176_T205_V1.5091.00
81_N85_E1.5071.00
334_E366_N1.5071.00
270_L308_K1.4931.00
295_L392_A1.4891.00
78_N81_N1.4851.00
274_V308_K1.4751.00
303_D396_R1.4681.00
27_A41_S1.4571.00
71_E74_T1.4561.00
194_E198_R1.4511.00
77_R124_K1.4421.00
265_F425_R1.4411.00
66_A432_A1.4401.00
36_G364_G1.4271.00
354_V373_L1.4231.00
37_D364_G1.4191.00
87_Q106_K1.4151.00
276_G419_Y1.4111.00
296_Y397_F1.4091.00
92_R96_L1.4071.00
302_Y374_V1.4051.00
401_A432_A1.4001.00
345_A348_L1.3971.00
297_V305_F1.3961.00
67_L71_E1.3951.00
416_A435_Y1.3941.00
312_A315_K1.3941.00
266_D425_R1.3901.00
88_D92_R1.3881.00
80_F117_E1.3841.00
81_N117_E1.3821.00
402_D406_Q1.3811.00
304_R307_E1.3791.00
122_E125_R1.3791.00
277_A295_L1.3791.00
31_T38_K1.3731.00
143_I431_E1.3681.00
116_I164_T1.3471.00
317_H325_G1.3461.00
49_E52_A1.3381.00
86_H191_A1.3361.00
152_A177_M1.3351.00
92_R322_L1.3281.00
340_V389_G1.3281.00
26_E44_K1.3221.00
218_N244_Q1.3191.00
242_M460_L1.3191.00
399_D402_D1.3121.00
343_H387_T1.3091.00
350_K381_K1.3051.00
397_F406_Q1.3011.00
337_V341_E1.3001.00
228_K253_S1.2801.00
303_D307_E1.2771.00
337_V368_F1.2761.00
163_I179_L1.2751.00
95_T105_A1.2751.00
265_F397_F1.2721.00
338_A342_E1.2681.00
32_N35_N1.2621.00
61_L176_T1.2581.00
311_Q314_S1.2531.00
193_A206_F1.2521.00
337_V360_A1.2511.00
222_S247_K1.2491.00
314_S356_C1.2411.00
265_F429_V1.2381.00
306_A310_Q1.2331.00
334_E337_V1.2301.00
54_I223_N1.2281.00
404_I429_V1.2201.00
80_F84_M1.2111.00
47_A219_E1.2061.00
319_G326_V1.2031.00
301_V304_R1.1981.00
298_Q399_D1.1971.00
263_I403_V1.1961.00
467_Y470_E1.1941.00
298_Q301_V1.1921.00
379_N384_K1.1921.00
44_K212_S1.1921.00
196_A206_F1.1901.00
311_Q315_K1.1811.00
141_I427_F1.1811.00
317_H327_T1.1781.00
50_T216_V1.1751.00
183_S212_S1.1721.00
55_D59_R1.1701.00
144_K475_I1.1701.00
218_N240_Q1.1691.00
466_K470_E1.1631.00
183_S213_A1.1601.00
308_K312_A1.1581.00
342_E346_D1.1551.00
54_I225_L1.1531.00
67_L75_I1.1491.00
204_G207_N1.1471.00
95_T321_G1.1371.00
54_I226_V1.1331.00
306_A374_V1.1321.00
430_G478_M1.1321.00
92_R102_L1.1311.00
416_A438_V1.1301.00
309_L392_A1.1291.00
90_L191_A1.1261.00
378_A409_D1.1241.00
305_F309_L1.1181.00
401_A428_R1.1141.00
240_Q244_Q1.1091.00
237_I240_Q1.1081.00
79_W195_L1.1071.00
426_V440_I1.1061.00
78_N82_L1.1041.00
56_A207_N1.1041.00
347_A373_L1.0941.00
147_I228_K1.0931.00
306_A355_V1.0931.00
236_E240_Q1.0901.00
28_I44_K1.0881.00
352_A373_L1.0831.00
32_N320_D1.0821.00
384_K411_E1.0791.00
167_A206_F1.0781.00
453_G462_R1.0741.00
384_K409_D1.0691.00
190_L210_T1.0691.00
467_Y475_I1.0691.00
77_R121_E1.0681.00
129_D466_K1.0681.00
262_F292_A1.0681.00
401_A405_A1.0661.00
79_W201_V1.0641.00
151_A220_L1.0641.00
242_M252_V1.0581.00
40_G187_F1.0571.00
310_Q356_C1.0571.00
79_W116_I1.0541.00
361_H369_Q1.0521.00
152_A230_S1.0471.00
219_E223_N1.0461.00
263_I429_V1.0461.00
314_S369_Q1.0451.00
316_L328_I1.0421.00
350_K380_A1.0411.00
404_I432_A1.0401.00
462_R474_E1.0381.00
44_K215_A1.0331.00
129_D467_Y1.0321.00
167_A177_M1.0301.00
34_A321_G1.0201.00
422_D425_R1.0181.00
151_A226_V1.0181.00
357_G371_T1.0081.00
269_D421_R1.0041.00
63_A67_L1.0021.00
337_V366_N0.9961.00
400_E429_V0.9951.00
263_I407_A0.9931.00
90_L195_L0.9921.00
36_G366_N0.9901.00
47_A215_A0.9891.00
397_F403_V0.9891.00
158_F288_T0.9871.00
62_P405_A0.9861.00
60_A176_T0.9831.00
73_A124_K0.9811.00
239_R249_I0.9771.00
85_E198_R0.9721.00
346_D349_E0.9711.00
194_E197_I0.9711.00
357_G369_Q0.9691.00
86_H195_L0.9691.00
259_N293_N0.9651.00
123_G172_A0.9651.00
269_D272_K0.9631.00
62_P434_E0.9601.00
190_L208_V0.9591.00
58_N62_P0.9541.00
143_I478_M0.9531.00
340_V391_L0.9521.00
320_D323_D0.9521.00
112_A164_T0.9521.00
149_V176_T0.9511.00
455_I474_E0.9461.00
271_D304_R0.9411.00
86_H194_E0.9401.00
91_A106_K0.9381.00
278_L312_A0.9371.00
343_H346_D0.9351.00
272_K276_G0.9351.00
261_P416_A0.9341.00
89_D92_R0.9341.00
376_V380_A0.9261.00
77_R120_A0.9251.00
147_I251_K0.9241.00
405_A409_D0.9231.00
242_M246_A0.9231.00
280_S292_A0.9231.00
417_Y443_G0.9201.00
32_N96_L0.9181.00
47_A51_R0.9161.00
96_L322_L0.9141.00
140_L450_A0.9131.00
342_E345_A0.9061.00
82_L86_H0.9051.00
281_K293_N0.9021.00
303_D306_A0.9011.00
145_Q431_E0.9011.00
227_R434_E0.8991.00
62_P66_A0.8951.00
150_T228_K0.8881.00
98_Q185_T0.8831.00
32_N37_D0.8831.00
69_A73_A0.8811.00
302_Y394_L0.8801.00
265_F400_E0.8791.00
270_L274_V0.8781.00
74_T78_N0.8781.00
262_F419_Y0.8761.00
239_R243_E0.8761.00
73_A77_R0.8761.00
100_K108_E0.8751.00
352_A380_A0.8751.00
149_V226_V0.8731.00
338_A341_E0.8721.00
145_Q455_I0.8721.00
242_M245_C0.8711.00
65_R434_E0.8691.00
340_V387_T0.8671.00
50_T151_A0.8671.00
274_V309_L0.8661.00
31_T366_N0.8661.00
343_H381_K0.8661.00
395_F406_Q0.8641.00
184_Q335_K0.8641.00
80_F120_A0.8611.00
274_V312_A0.8601.00
193_A197_I0.8591.00
265_F420_A0.8581.00
112_A160_A0.8571.00
427_F431_E0.8561.00
52_A56_A0.8511.00
378_A395_F0.8451.00
83_M112_A0.8441.00
348_L373_L0.8431.00
234_S237_I0.8421.00
66_A431_E0.8391.00
450_A477_Y0.8371.00
73_A120_A0.8361.00
416_A433_L0.8351.00
403_V406_Q0.8341.00
229_L245_C0.8341.00
48_D52_A0.8291.00
166_K463_E0.8281.00
60_A205_V0.8261.00
251_K474_E0.8261.00
147_I474_E0.8231.00
28_I212_S0.8221.00
63_A66_A0.8191.00
404_I408_N0.8181.00
190_L194_E0.8161.00
57_A207_N0.8121.00
34_A367_F0.8121.00
173_A473_L0.8111.00
397_F402_D0.8101.00
147_I175_C0.8101.00
56_A204_G0.8101.00
274_V305_F0.8081.00
48_D51_R0.8061.00
273_A277_A0.8051.00
358_G371_T0.8041.00
229_L241_L0.8021.00
347_A387_T0.7991.00
264_V305_F0.7971.00
418_F429_V0.7971.00
45_M49_E0.7951.00
307_E310_Q0.7941.00
179_L189_A0.7941.00
242_M249_I0.7931.00
64_W205_V0.7911.00
423_L426_V0.7911.00
59_R62_P0.7901.00
318_I361_H0.7891.00
52_A55_D0.7891.00
170_A177_M0.7851.00
238_G256_L0.7851.00
163_I167_A0.7831.00
374_V396_R0.7791.00
77_R81_N0.7751.00
169_P468_G0.7741.00
39_L96_L0.7731.00
351_G380_A0.7671.00
98_Q332_I0.7671.00
181_P210_T0.7651.00
221_T241_L0.7641.00
83_M113_A0.7641.00
344_I391_L0.7601.00
340_V368_F0.7591.00
103_A327_T0.7571.00
435_Y438_V0.7571.00
221_T244_Q0.7561.00
76_L172_A0.7541.00
302_Y375_D0.7541.00
70_K124_K0.7521.00
84_M87_Q0.7521.00
164_T192_L0.7511.00
273_A305_F0.7511.00
309_L372_I0.7511.00
95_T102_L0.7501.00
239_R247_K0.7471.00
238_G254_L0.7461.00
45_M53_A0.7451.00
335_K338_A0.7451.00
316_L327_T0.7431.00
235_T457_A0.7421.00
270_L301_V0.7401.00
91_A102_L0.7391.00
245_C252_V0.7381.00
201_V206_F0.7351.00
201_V205_V0.7331.00
96_L187_F0.7331.00
313_V356_C0.7321.00
261_P407_A0.7311.00
260_A293_N0.7311.00
152_A166_K0.7301.00
211_G216_V0.7281.00
102_L322_L0.7281.00
62_P65_R0.7271.00
298_Q400_E0.7271.00
231_F237_I0.7261.00
91_A95_T0.7261.00
160_A188_S0.7241.00
78_N199_A0.7241.00
221_T229_L0.7221.00
274_V278_L0.7211.00
32_N322_L0.7211.00
271_D312_A0.7201.00
84_M110_S0.7181.00
421_R424_S0.7161.00
348_L359_K0.7151.00
310_Q313_V0.7121.00
151_A229_L0.7111.00
106_K324_N0.7091.00
343_H385_E0.7091.00
323_D326_V0.7071.00
278_L309_L0.7071.00
26_E215_A0.7071.00
50_T219_E0.7071.00
219_E222_S0.7051.00
184_Q332_I0.7021.00
88_D102_L0.6991.00
147_I227_R0.6991.00
179_L206_F0.6961.00
57_A176_T0.6951.00
140_L477_Y0.6941.00
339_K342_E0.6921.00
163_I189_A0.6891.00
154_T163_I0.6871.00
64_W75_I0.6861.00
297_V301_V0.6851.00
244_Q247_K0.6821.00
265_F298_Q0.6811.00
31_T36_G0.6801.00
296_Y378_A0.6791.00
183_S339_K0.6781.00
175_C473_L0.6771.00
93_L187_F0.6771.00
60_A63_A0.6771.00
336_A339_K0.6771.00
313_V316_L0.6771.00
50_T54_I0.6741.00
36_G334_E0.6731.00
58_N61_L0.6721.00
243_E246_A0.6721.00
89_D194_E0.6681.00
267_D420_A0.6661.00
378_A383_S0.6651.00
94_M97_E0.6641.00
318_I328_I0.6641.00
81_N84_M0.6631.00
75_I199_A0.6631.00
163_I192_L0.6611.00
423_L427_F0.6601.00
27_A43_P0.6591.00
285_A328_I0.6581.00
337_V361_H0.6581.00
296_Y383_S0.6571.00
295_L305_F0.6571.00
333_D336_A0.6561.00
334_E360_A0.6561.00
278_L316_L0.6551.00
344_I373_L0.6531.00
399_D405_A0.6531.00
65_R432_A0.6521.00
69_A123_G0.6501.00
64_W171_L0.6501.00
406_Q409_D0.6491.00
251_K471_D0.6481.00
320_D326_V0.6481.00
51_R225_L0.6481.00
109_I113_A0.6471.00
272_K275_E0.6461.00
350_K379_N0.6451.00
368_F371_T0.6441.00
65_R146_P0.6441.00
151_A217_G0.6441.00
56_A203_A0.6441.00
178_V207_N0.6431.00
430_G440_I0.6421.00
139_R427_F0.6411.00
264_V273_A0.6381.00
335_K339_K0.6381.00
62_P432_A0.6381.00
270_L304_R0.6371.00
434_E455_I0.6371.00
400_E404_I0.6351.00
470_E473_L0.6341.00
277_A309_L0.6341.00
470_E475_I0.6331.00
196_A201_V0.6321.00
71_E75_I0.6321.00
183_S240_Q0.6311.00
426_V430_G0.6301.00
90_L160_A0.6291.00
43_P210_T0.6281.00
376_V383_S0.6281.00
341_E344_I0.6271.00
126_I473_L0.6261.00
309_L394_L0.6261.00
143_I476_K0.6261.00
75_I200_G0.6251.00
420_A425_R0.6251.00
356_C372_I0.6241.00
45_M209_V0.6231.00
272_K421_R0.6221.00
80_F113_A0.6211.00
140_L479_C0.6181.00
100_K104_E0.6181.00
358_G369_Q0.6181.00
95_T322_L0.6181.00
87_Q91_A0.6171.00
65_R145_Q0.6171.00
373_L376_V0.6161.00
30_V40_G0.6151.00
191_A195_L0.6121.00
253_S471_D0.6081.00
167_A179_L0.6071.00
166_K230_S0.6071.00
69_A172_A0.6061.00
424_S427_F0.6051.00
242_M254_L0.6051.00
141_I478_M0.6051.00
30_V97_E0.6011.00
297_V302_Y0.6011.00
215_A218_N0.6001.00
53_A209_V0.6001.00
94_M188_S0.5991.00
418_F426_V0.5981.00
100_K158_F0.5971.00
47_A222_S0.5961.00
387_T391_L0.5941.00
126_I469_I0.5921.00
42_V186_P0.5911.00
94_M105_A0.5911.00
55_D58_N0.5901.00
354_V357_G0.5891.00
92_R95_T0.5881.00
404_I428_R0.5871.00
160_A192_L0.5861.00
262_F295_L0.5851.00
267_D421_R0.5851.00
331_L336_A0.5851.00
354_V371_T0.5851.00
267_D422_D0.5841.00
424_S428_R0.5821.00
176_T207_N0.5821.00
83_M116_I0.5821.00
318_I327_T0.5781.00
297_V394_L0.5771.00
118_W122_E0.5751.00
376_V382_V0.5751.00
83_M192_L0.5741.00
39_L187_F0.5741.00
83_M160_A0.5741.00
280_S443_G0.5741.00
375_D396_R0.5741.00
150_T175_C0.5721.00
217_G221_T0.5711.00
288_T291_C0.5701.00
82_L200_G0.5681.00
235_T239_R0.5681.00
360_A369_Q0.5681.00
94_M108_E0.5671.00
310_Q372_I0.5641.00
262_F417_Y0.5621.00
281_K392_A0.5621.00
59_R63_A0.5621.00
228_K471_D0.5611.00
211_G217_G0.5611.00
407_A433_L0.5611.00
80_F116_I0.5601.00
270_L273_A0.5601.00
221_T248_D0.5571.00
437_I446_S0.5571.00
271_D311_Q0.5561.00
378_A405_A0.5541.00
404_I433_L0.5541.00
418_F440_I0.5531.00
109_I160_A0.5521.00
341_E348_L0.5511.00
56_A60_A0.5501.00
26_E46_G0.5491.00
382_V387_T0.5491.00
403_V407_A0.5481.00
150_T177_M0.5471.00
344_I371_T0.5461.00
149_V227_R0.5461.00
57_A178_V0.5451.00
270_L305_F0.5441.00
183_S236_E0.5441.00
79_W82_L0.5441.00
91_A109_I0.5431.00
58_N149_V0.5431.00
317_H323_D0.5431.00
434_E474_E0.5421.00
295_L394_L0.5421.00
53_A207_N0.5411.00
400_E432_A0.5401.00
438_V476_K0.5401.00
299_D302_Y0.5381.00
266_D397_F0.5381.00
268_A273_A0.5381.00
359_K362_E0.5351.00
75_I79_W0.5351.00
69_A127_Y0.5351.00
192_L196_A0.5341.00
30_V186_P0.5341.00
439_G442_T0.5341.00
161_A165_R0.5341.00
213_A218_N0.5331.00
63_A176_T0.5331.00
119_F169_P0.5331.00
121_E124_K0.5321.00
350_K377_P0.5301.00
292_A417_Y0.5301.00
173_A469_I0.5291.00
145_Q434_E0.5281.00
70_K74_T0.5281.00
260_A415_A0.5281.00
90_L109_I0.5261.00
197_I204_G0.5251.00
171_L206_F0.5251.00
42_V187_F0.5241.00
339_K343_H0.5241.00
87_Q113_A0.5231.00
274_V301_V0.5221.00
57_A149_V0.5221.00
110_S113_A0.5221.00
236_E335_K0.5211.00
429_V433_L0.5211.00
111_Y161_A0.5211.00
152_A167_A0.5201.00
122_E466_K0.5191.00
98_Q284_N0.5181.00
74_T77_R0.5181.00
378_A384_K0.5181.00
83_M90_L0.5141.00
44_K183_S0.5141.00
78_N200_G0.5141.00
331_L368_F0.5131.00
307_E314_S0.5121.00
53_A178_V0.5121.00
151_A178_V0.5101.00
347_A381_K0.5091.00
282_F316_L0.5081.00
30_V39_L0.5081.00
224_P411_E0.5071.00
252_V460_L0.5071.00
108_E158_F0.5071.00
355_V375_D0.5071.00
348_L352_A0.5051.00
405_A432_A0.5021.00
91_A105_A0.5021.00
171_L201_V0.5011.00
178_V209_V0.5011.00
309_L313_V0.5001.00
106_K110_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ek1A 5 0.9959 100 0.019 Contact Map
4o5hA 4 1 100 0.019 Contact Map
4pxlA 4 0.9876 100 0.02 Contact Map
4qf6A 4 0.9979 100 0.02 Contact Map
4yweA 5 0.9751 100 0.022 Contact Map
1a4sA 4 0.9959 100 0.023 Contact Map
4wj9A 4 0.9979 100 0.024 Contact Map
4pz2A 4 0.9938 100 0.025 Contact Map
4qtoA 4 0.9959 100 0.026 Contact Map
3ifgA 6 0.9979 100 0.028 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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