GREMLIN Database
CODA - Cytosine deaminase
UniProt: P25524 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11326
Length: 427 (347)
Sequences: 33008 (25230)
Seq/√Len: 1354.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
399_V404_V4.8411.00
9_I49_A4.2341.00
52_G396_R3.9101.00
26_Q31_S3.7401.00
397_Y404_V3.7221.00
49_A379_I3.4461.00
370_A373_N3.3091.00
55_I380_L3.2491.00
346_Q349_D3.1831.00
57_P118_Q3.1131.00
12_A49_A3.1061.00
367_Y374_S3.0921.00
10_I46_S2.8291.00
300_K304_E2.7931.00
374_S401_G2.6911.00
32_A371_A2.6651.00
364_L367_Y2.4241.00
28_G374_S2.3891.00
55_I378_I2.3631.00
8_T24_H2.3161.00
235_H269_S2.2951.00
264_R305_S2.2831.00
308_N360_R2.2791.00
34_D37_S2.2521.00
204_L207_K2.1961.00
352_N356_H2.1931.00
23_I54_V2.1711.00
54_V379_I2.1121.00
22_Q37_S2.1111.00
369_I377_L2.1071.00
45_N407_S2.0951.00
29_K374_S2.0751.00
377_L399_V2.0651.00
349_D352_N2.0521.00
25_L377_L2.0231.00
7_Q399_V2.0231.00
381_P396_R2.0011.00
52_G381_P1.9831.00
54_V377_L1.9181.00
398_S406_A1.9081.00
28_G401_G1.8931.00
52_G379_I1.8631.00
12_A54_V1.8341.00
404_V407_S1.8031.00
41_P44_E1.7911.00
24_H44_E1.7701.00
113_I405_I1.7671.00
10_I22_Q1.7621.00
14_L21_W1.7471.00
11_N48_D1.7461.00
360_R365_Q1.7021.00
264_R268_M1.6911.00
357_H360_R1.6441.00
378_I395_V1.6271.00
114_A406_A1.6251.00
55_I58_F1.6171.00
147_W151_Q1.6171.00
336_L350_G1.5881.00
366_D373_N1.5781.00
352_N357_H1.5681.00
18_E21_W1.5481.00
24_H32_A1.5301.00
310_C361_T1.5111.00
199_H203_A1.5001.00
23_I369_I1.4931.00
146_P151_Q1.4831.00
199_H236_H1.4631.00
9_I25_L1.4601.00
303_L349_D1.4561.00
30_I369_I1.4511.00
195_V199_H1.4441.00
356_H360_R1.4401.00
351_L355_T1.4361.00
265_L269_S1.4341.00
397_Y407_S1.4331.00
135_K139_E1.4311.00
33_I371_A1.4311.00
203_A207_K1.4091.00
22_Q36_Q1.4061.00
298_R301_E1.3991.00
356_H373_N1.3831.00
7_Q25_L1.3791.00
23_I377_L1.3771.00
232_A236_H1.3731.00
379_I399_V1.3631.00
8_T22_Q1.3571.00
206_Q243_V1.3561.00
142_Q145_A1.3411.00
136_A139_E1.3261.00
53_L382_A1.3041.00
200_K203_A1.3001.00
263_F305_S1.2961.00
327_N330_Q1.2931.00
171_E175_R1.2841.00
13_R18_E1.2811.00
112_Q120_V1.2791.00
49_A54_V1.2781.00
400_R405_I1.2761.00
21_W35_A1.2721.00
204_L208_Y1.2621.00
59_V358_S1.2561.00
253_S301_E1.2551.00
275_A279_V1.2551.00
13_R19_G1.2511.00
379_I397_Y1.2511.00
186_H189_F1.2421.00
61_P310_C1.2411.00
11_N51_Q1.2351.00
172_E176_L1.2341.00
25_L399_V1.2331.00
302_M307_I1.2301.00
229_T233_L1.2111.00
196_E199_H1.2101.00
380_L395_V1.2031.00
213_D246_S1.1931.00
11_N20_L1.1921.00
365_Q373_N1.1921.00
55_I351_L1.1921.00
61_P358_S1.1901.00
265_L268_M1.1881.00
64_H247_H1.1851.00
13_R20_L1.1851.00
24_H31_S1.1781.00
9_I377_L1.1751.00
276_N279_V1.1711.00
17_E356_H1.1691.00
14_L23_I1.1631.00
179_D184_I1.1611.00
61_P362_L1.1521.00
169_L172_E1.1471.00
272_N308_N1.1471.00
21_W34_D1.1441.00
248_T273_F1.1411.00
272_N361_T1.1391.00
136_A140_V1.1391.00
220_D224_S1.1381.00
59_V119_H1.1371.00
332_L354_I1.1341.00
171_E208_Y1.1321.00
310_C357_H1.1311.00
333_H337_H1.1181.00
145_A151_Q1.1151.00
22_Q38_G1.1141.00
11_N50_E1.1101.00
9_I399_V1.0991.00
381_P394_P1.0981.00
45_N404_V1.0891.00
47_L399_V1.0851.00
121_R362_L1.0841.00
106_W110_K1.0741.00
149_D153_V1.0731.00
34_D38_G1.0711.00
31_S371_A1.0681.00
245_A248_T1.0681.00
310_C358_S1.0681.00
22_Q34_D1.0631.00
24_H41_P1.0621.00
162_S165_N1.0611.00
211_L363_N1.0571.00
12_A379_I1.0521.00
301_E304_E1.0511.00
21_W33_I1.0501.00
353_L357_H1.0431.00
252_H255_N1.0351.00
61_P274_V1.0321.00
119_H367_Y1.0311.00
293_R297_T1.0311.00
32_A38_G1.0271.00
170_L174_L1.0261.00
174_L210_R1.0201.00
168_A172_E1.0181.00
301_E305_S1.0181.00
205_A212_I1.0181.00
267_K307_I1.0131.00
130_T133_A1.0121.00
143_E146_P1.0111.00
59_V367_Y1.0091.00
386_F394_P1.0071.00
169_L173_A0.9971.00
253_S298_R0.9971.00
171_E204_L0.9901.00
147_W153_V0.9891.00
266_L273_F0.9871.00
146_P149_D0.9801.00
15_P351_L0.9781.00
329_L333_H0.9761.00
189_F192_E0.9711.00
59_V359_A0.9691.00
24_H43_T0.9501.00
205_A210_R0.9471.00
172_E175_R0.9461.00
164_P167_E0.9461.00
330_Q333_H0.9421.00
248_T251_M0.9411.00
185_P189_F0.9321.00
7_Q45_N0.9321.00
274_V310_C0.9311.00
30_I377_L0.9301.00
106_W143_E0.9301.00
232_A235_H0.9291.00
215_H314_D0.9261.00
148_I152_I0.9261.00
175_R208_Y0.9261.00
267_K309_V0.9241.00
231_A235_H0.9231.00
378_I398_S0.9231.00
178_A182_G0.9181.00
47_L397_Y0.9161.00
179_D182_G0.9111.00
133_A137_M0.9101.00
181_V184_I0.9091.00
185_P188_E0.9081.00
102_K139_E0.9081.00
247_H314_D0.9081.00
187_F190_T0.9061.00
9_I47_L0.9011.00
9_I54_V0.9001.00
168_A171_E0.8991.00
109_L113_I0.8951.00
160_I163_Y0.8941.00
10_I48_D0.8921.00
131_L135_K0.8901.00
209_D242_R0.8891.00
233_L237_E0.8841.00
267_K270_G0.8771.00
13_R53_L0.8731.00
43_T46_S0.8701.00
231_A234_A0.8681.00
267_K305_S0.8651.00
133_A140_V0.8621.00
133_A138_L0.8591.00
59_V362_L0.8591.00
332_L350_G0.8581.00
171_E207_K0.8571.00
329_L332_L0.8551.00
133_A136_A0.8541.00
35_A38_G0.8431.00
280_N283_L0.8411.00
113_I400_R0.8411.00
157_Q161_L0.8391.00
65_L108_T0.8361.00
132_T135_K0.8341.00
328_M354_I0.8321.00
24_H34_D0.8291.00
325_T330_Q0.8281.00
113_I406_A0.8261.00
229_T232_A0.8261.00
158_E161_L0.8251.00
163_Y167_E0.8241.00
134_L137_M0.8241.00
147_W152_I0.8231.00
354_I358_S0.8211.00
119_H376_N0.8181.00
49_A52_G0.8111.00
123_H213_D0.8111.00
202_F212_I0.8051.00
62_H247_H0.8021.00
293_R296_I0.7991.00
264_R267_K0.7971.00
180_V184_I0.7961.00
251_M302_M0.7961.00
58_F354_I0.7951.00
198_L214_V0.7941.00
111_W114_A0.7941.00
130_T135_K0.7931.00
130_T138_L0.7921.00
141_K145_A0.7921.00
15_P53_L0.7911.00
244_T361_T0.7911.00
52_G397_Y0.7891.00
137_M140_V0.7881.00
15_P18_E0.7831.00
180_V183_A0.7771.00
102_K143_E0.7751.00
383_E386_F0.7741.00
376_N401_G0.7741.00
64_H215_H0.7721.00
230_V234_A0.7711.00
13_R383_E0.7691.00
110_K114_A0.7671.00
18_E348_N0.7661.00
243_V247_H0.7641.00
113_I398_S0.7631.00
348_N352_N0.7611.00
7_Q47_L0.7611.00
156_P159_G0.7611.00
251_M298_R0.7601.00
327_N333_H0.7591.00
107_Q110_K0.7571.00
130_T137_M0.7561.00
117_I328_M0.7551.00
146_P152_I0.7541.00
132_T136_A0.7521.00
266_L269_S0.7511.00
173_A176_L0.7501.00
65_L109_L0.7501.00
215_H247_H0.7451.00
229_T234_A0.7441.00
161_L165_N0.7421.00
11_N49_A0.7401.00
359_A368_G0.7371.00
367_Y376_N0.7361.00
223_Q255_N0.7361.00
385_G389_L0.7361.00
367_Y373_N0.7361.00
188_E191_R0.7351.00
149_D152_I0.7341.00
60_E313_H0.7331.00
20_L50_E0.7321.00
163_Y166_G0.7291.00
64_H314_D0.7271.00
395_V398_S0.7271.00
155_F158_E0.7261.00
24_H37_S0.7251.00
107_Q111_W0.7241.00
325_T329_L0.7231.00
135_K138_L0.7231.00
276_N312_G0.7211.00
142_Q147_W0.7171.00
62_H215_H0.7171.00
148_I151_Q0.7171.00
23_I33_I0.7161.00
156_P162_S0.7151.00
65_L120_V0.7141.00
63_I112_Q0.7131.00
60_E63_I0.7131.00
334_M338_V0.7131.00
229_T235_H0.7121.00
235_H265_L0.7111.00
22_Q32_A0.7111.00
186_H190_T0.7101.00
234_A237_E0.7061.00
197_S200_K0.7011.00
341_L345_G0.7011.00
12_A377_L0.7001.00
143_E147_W0.6921.00
300_K303_L0.6921.00
216_C245_A0.6901.00
62_H314_D0.6861.00
132_T137_M0.6861.00
159_G162_S0.6851.00
157_Q160_I0.6831.00
118_Q398_S0.6821.00
17_E351_L0.6821.00
308_N357_H0.6811.00
21_W369_I0.6801.00
37_S40_M0.6791.00
359_A373_N0.6791.00
275_A278_L0.6731.00
154_A157_Q0.6721.00
273_F307_I0.6711.00
340_Q345_G0.6671.00
229_T237_E0.6661.00
327_N334_M0.6631.00
21_W36_Q0.6621.00
102_K136_A0.6611.00
174_L208_Y0.6601.00
324_G327_N0.6591.00
157_Q162_S0.6581.00
17_E348_N0.6571.00
331_V335_G0.6571.00
213_D244_T0.6561.00
142_Q146_P0.6531.00
118_Q376_N0.6511.00
311_F353_L0.6481.00
263_F302_M0.6481.00
144_V149_D0.6461.00
147_W150_L0.6431.00
233_L236_H0.6411.00
251_M254_Y0.6401.00
195_V236_H0.6351.00
275_A299_V0.6341.00
20_L36_Q0.6331.00
145_A152_I0.6331.00
272_N310_C0.6321.00
32_A37_S0.6311.00
145_A148_I0.6291.00
244_T272_N0.6281.00
334_M337_H0.6271.00
381_P384_N0.6261.00
311_F335_G0.6251.00
170_L173_A0.6241.00
10_I36_Q0.6241.00
247_H250_A0.6231.00
356_H365_Q0.6181.00
159_G164_P0.6181.00
145_A149_D0.6161.00
196_E200_K0.6161.00
8_T43_T0.6161.00
266_L271_I0.6141.00
14_L19_G0.6141.00
121_R244_T0.6131.00
25_L31_S0.6121.00
142_Q151_Q0.6111.00
66_D125_D0.6101.00
53_L380_L0.6071.00
250_A253_S0.6071.00
219_I223_Q0.6061.00
30_I373_N0.6041.00
159_G163_Y0.6041.00
366_D374_S0.6031.00
220_D223_Q0.6031.00
274_V278_L0.6031.00
275_A280_N0.6011.00
279_V283_L0.6011.00
156_P160_I0.5981.00
326_A329_L0.5981.00
139_E143_E0.5971.00
270_G308_N0.5971.00
397_Y406_A0.5961.00
160_I165_N0.5961.00
160_I166_G0.5951.00
245_A266_L0.5931.00
150_L153_V0.5921.00
102_K106_W0.5911.00
20_L33_I0.5911.00
330_Q334_M0.5901.00
155_F159_G0.5881.00
280_N284_Q0.5871.00
143_E151_Q0.5871.00
214_V230_V0.5861.00
20_L35_A0.5851.00
58_F117_I0.5851.00
109_L120_V0.5831.00
197_S201_T0.5811.00
177_G180_V0.5811.00
162_S166_G0.5781.00
178_A181_V0.5771.00
32_A40_M0.5761.00
161_L164_P0.5751.00
201_T204_L0.5731.00
294_R297_T0.5711.00
263_F267_K0.5711.00
218_E221_D0.5701.00
151_Q154_A0.5701.00
263_F301_E0.5691.00
232_A254_Y0.5681.00
128_D131_L0.5671.00
169_L175_R0.5671.00
229_T255_N0.5651.00
58_F395_V0.5651.00
217_D249_T0.5641.00
241_A247_H0.5631.00
145_A153_V0.5621.00
121_R246_S0.5621.00
221_D224_S0.5611.00
250_A254_Y0.5611.00
333_H338_V0.5601.00
401_G404_V0.5601.00
296_I300_K0.5601.00
274_V279_V0.5581.00
244_T250_A0.5581.00
326_A336_L0.5561.00
199_H237_E0.5561.00
148_I153_V0.5561.00
100_D103_Q0.5551.00
15_P348_N0.5551.00
230_V233_L0.5541.00
157_Q163_Y0.5541.00
347_I385_G0.5511.00
246_S274_V0.5501.00
325_T328_M0.5481.00
7_Q44_E0.5471.00
177_G182_G0.5451.00
131_L134_L0.5451.00
23_I30_I0.5451.00
63_I120_V0.5451.00
324_G329_L0.5451.00
146_P153_V0.5441.00
8_T46_S0.5441.00
10_I40_M0.5441.00
336_L340_Q0.5431.00
249_T252_H0.5431.00
144_V152_I0.5421.00
229_T236_H0.5411.00
155_F160_I0.5411.00
232_A265_L0.5361.00
19_G35_A0.5361.00
273_F302_M0.5361.00
336_L341_L0.5351.00
119_H364_L0.5331.00
251_M255_N0.5331.00
231_A265_L0.5321.00
146_P150_L0.5321.00
112_Q326_A0.5311.00
254_Y264_R0.5301.00
244_T247_H0.5291.00
58_F329_L0.5291.00
129_A132_T0.5291.00
327_N332_L0.5281.00
158_E162_S0.5281.00
202_F206_Q0.5271.00
203_A206_Q0.5251.00
246_S249_T0.5241.00
336_L347_I0.5231.00
65_L122_T0.5211.00
276_N280_N0.5201.00
230_V237_E0.5201.00
323_L331_V0.5201.00
17_E352_N0.5191.00
119_H362_L0.5181.00
47_L404_V0.5171.00
325_T331_V0.5171.00
178_A183_A0.5161.00
160_I164_P0.5161.00
123_H246_S0.5151.00
132_T138_L0.5141.00
235_H268_M0.5131.00
237_E240_G0.5131.00
8_T41_P0.5111.00
58_F378_I0.5111.00
58_F351_L0.5091.00
248_T266_L0.5091.00
167_E200_K0.5091.00
13_R382_A0.5061.00
376_N400_R0.5031.00
112_Q117_I0.5021.00
8_T44_E0.5021.00
147_W376_N0.5011.00
297_T301_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ra0A 4 0.9883 100 0.274 Contact Map
4r85A 4 0.9578 100 0.319 Contact Map
4dzhA 2 0.9251 100 0.338 Contact Map
4cqbA 2 0.9087 100 0.338 Contact Map
3ls9A 2 0.9297 100 0.338 Contact Map
2pajA 2 0.8478 100 0.34 Contact Map
3hpaA 2 0.911 100 0.344 Contact Map
4v1xA 5 0.9297 100 0.352 Contact Map
3lnpA 2 0.9204 100 0.353 Contact Map
4gbdA 2 0.9204 100 0.364 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0122 seconds.