GREMLIN Database
MNME - tRNA modification GTPase MnmE
UniProt: P25522 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10997
Length: 454 (444)
Sequences: 4635 (3389)
Seq/√Len: 160.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
46_A65_L4.4551.00
20_G90_L3.9921.00
284_I287_E3.7931.00
5_D104_R3.7391.00
28_K31_E3.6481.00
32_V103_L3.2971.00
124_A153_S3.2281.00
73_F112_S3.1141.00
262_D373_K3.0111.00
8_V94_L2.9161.00
246_D280_E2.9061.00
42_K45_Y2.8011.00
235_A365_V2.7481.00
24_I33_A2.6331.00
201_D400_A2.6041.00
371_H374_Q2.5521.00
176_F452_I2.4791.00
75_G120_K2.4721.00
300_L333_V2.4541.00
8_V97_I2.4371.00
30_R66_W2.4051.00
247_I279_D2.4031.00
65_L82_Q2.3051.00
305_G334_R2.2821.00
107_R113_E2.2821.00
302_M335_N2.2591.00
197_I400_A2.2571.00
222_A293_I2.2391.00
57_S142_R2.2131.00
190_E411_L2.1841.00
394_Q398_Q2.1781.00
13_P17_G2.1771.00
162_A192_Q2.1751.00
197_I404_Q2.1711.00
277_A286_I2.1601.00
157_N436_E2.1451.00
155_R199_D2.1411.00
333_V355_I2.1381.00
24_I97_I2.1201.00
353_A371_H2.1181.00
37_L49_L2.1101.00
48_Y61_Q2.1041.00
335_N359_A2.0521.00
194_N407_K2.0471.00
364_G367_V2.0311.00
413_A417_E2.0151.00
445_R449_S2.0061.00
291_Q295_Q2.0041.00
38_G52_K1.9941.00
16_R134_D1.9571.00
6_T28_K1.9541.00
337_A356_R1.9151.00
162_A195_D1.9041.00
254_V269_I1.8971.00
200_L396_L1.8961.00
217_M376_M1.8821.00
235_A362_G1.8821.00
70_P77_D1.8711.00
197_I407_K1.8701.00
160_V164_T1.8371.00
21_I82_Q1.8241.00
46_A63_I1.8161.00
73_F129_I1.8161.00
219_V266_L1.8081.00
220_V296_A1.7921.00
287_E291_Q1.7721.00
51_F62_G1.7661.00
6_T29_A1.7651.00
29_A79_L1.7561.00
231_S359_A1.7461.00
331_T371_H1.7391.00
112_S129_I1.7261.00
298_R372_L1.7251.00
402_H425_L1.7081.00
413_A416_G1.7051.00
132_L141_A1.7031.00
98_L105_I1.6851.00
398_Q432_E1.6801.00
62_G81_L1.6681.00
162_A199_D1.6531.00
400_A404_Q1.6511.00
50_P58_V1.6411.00
35_T101_P1.6321.00
201_D404_Q1.6261.00
201_D205_A1.6041.00
190_E407_K1.5991.00
168_I445_R1.5871.00
63_I67_F1.5811.00
88_V141_A1.5801.00
41_P66_W1.5531.00
283_R287_E1.5481.00
130_A134_D1.5401.00
245_T281_V1.5401.00
398_Q429_N1.5381.00
319_E322_A1.5271.00
300_L372_L1.5261.00
241_A257_E1.5251.00
72_S75_G1.4981.00
233_L242_A1.4801.00
280_E283_R1.4791.00
24_I81_L1.4711.00
131_D214_R1.4691.00
138_E141_A1.4641.00
361_T364_G1.4611.00
10_Q90_L1.4491.00
53_D57_S1.4361.00
29_A33_A1.4281.00
402_H422_E1.4261.00
394_Q397_E1.4201.00
218_K267_H1.4201.00
6_T32_V1.4191.00
238_G369_R1.4181.00
429_N432_E1.4161.00
303_V332_V1.4141.00
43_P66_W1.4111.00
197_I403_L1.4061.00
304_D307_T1.4011.00
405_Q422_E1.3971.00
33_A79_L1.3921.00
262_D370_N1.3881.00
408_A412_G1.3881.00
305_G340_T1.3821.00
311_V315_E1.3761.00
33_A64_A1.3731.00
393_L397_E1.3581.00
193_L403_L1.3561.00
370_N374_Q1.3431.00
141_A145_L1.3411.00
409_Q422_E1.3361.00
41_P47_D1.3281.00
8_V98_L1.3251.00
307_T310_A1.3241.00
298_R331_T1.3131.00
121_L129_I1.3091.00
312_D315_E1.3081.00
254_V292_E1.3081.00
225_P248_A1.3071.00
43_P68_P1.3021.00
161_E445_R1.2941.00
69_G77_D1.2841.00
30_R68_P1.2831.00
334_R356_R1.2831.00
237_A241_A1.2761.00
292_E295_Q1.2681.00
334_R354_L1.2601.00
396_L400_A1.2551.00
137_S260_H1.2541.00
406_G419_L1.2521.00
368_L372_L1.2501.00
402_H405_Q1.2441.00
197_I201_D1.2381.00
224_R310_A1.2371.00
83_G93_L1.2331.00
31_E34_E1.2281.00
52_K58_V1.2261.00
29_A32_V1.2251.00
442_L446_I1.2161.00
97_I103_L1.2101.00
260_H265_P1.2081.00
95_K390_R1.2071.00
305_G337_A1.2021.00
18_G78_V1.1981.00
247_I280_E1.1971.00
288_R292_E1.1961.00
337_A363_E1.1931.00
281_V284_I1.1881.00
291_Q294_E1.1861.00
96_R99_T1.1851.00
10_Q20_G1.1791.00
182_D185_S1.1751.00
243_I284_I1.1711.00
59_L96_R1.1701.00
266_L372_L1.1661.00
68_P77_D1.1631.00
172_A176_F1.1621.00
311_V314_A1.1611.00
401_E405_Q1.1611.00
235_A359_A1.1561.00
31_E35_T1.1441.00
57_S92_L1.1421.00
127_E391_R1.1411.00
32_V97_I1.1401.00
404_Q407_K1.1361.00
158_H162_A1.1301.00
154_A158_H1.1301.00
22_L94_L1.1211.00
190_E194_N1.1201.00
258_H265_P1.1201.00
113_E117_L1.1191.00
6_T27_F1.1181.00
8_V24_I1.1181.00
395_A429_N1.1151.00
231_S357_L1.1101.00
331_T372_L1.1091.00
333_V357_L1.1051.00
131_D389_R1.1031.00
224_R313_P1.1021.00
144_A148_L1.1001.00
258_H267_H1.0981.00
153_S157_N1.0961.00
18_G21_I1.0890.99
355_I371_H1.0800.99
52_K56_G1.0790.99
156_V430_L1.0770.99
126_A129_I1.0760.99
389_R392_H1.0740.99
90_L93_L1.0660.99
53_D96_R1.0650.99
305_G341_G1.0640.99
10_Q94_L1.0630.99
171_E424_R1.0580.99
137_S140_A1.0560.99
171_E178_D1.0560.99
390_R393_L1.0500.99
96_R101_P1.0490.99
36_V97_I1.0420.99
431_S437_F1.0390.99
260_H263_G1.0350.99
387_L396_L1.0330.99
405_Q408_A1.0310.99
200_L399_A1.0280.99
175_D181_I1.0230.99
67_F72_S1.0190.99
161_E165_H1.0150.99
188_K192_Q1.0140.99
81_L93_L1.0130.99
357_L360_R1.0050.99
92_L138_E1.0030.99
277_A280_E1.0030.99
371_H375_S1.0020.99
211_S239_R0.9990.99
86_G90_L0.9980.99
53_D99_T0.9970.99
284_I288_R0.9970.99
236_L369_R0.9950.99
62_G65_L0.9890.99
398_Q401_E0.9880.99
143_S147_S0.9870.99
183_F186_D0.9850.99
165_H192_Q0.9830.99
104_R110_E0.9750.99
185_S188_K0.9740.99
159_L196_V0.9700.99
373_K377_G0.9630.99
50_P61_Q0.9600.99
30_R34_E0.9590.99
182_D186_D0.9540.99
110_E114_R0.9460.99
367_V371_H0.9430.99
147_S388_A0.9420.99
280_E284_I0.9330.98
406_G423_L0.9310.98
219_V268_I0.9300.98
29_A78_V0.9300.98
28_K32_V0.9290.98
171_E174_I0.9270.98
22_L93_L0.9270.98
301_F317_W0.9250.98
301_F332_V0.9230.98
200_L403_L0.9210.98
390_R394_Q0.9210.98
255_L289_A0.9190.98
256_R292_E0.9170.98
11_A19_V0.9170.98
191_A194_N0.9160.98
237_A257_E0.9120.98
188_K191_A0.9120.98
366_D369_R0.9070.98
333_V368_L0.9050.98
194_N197_I0.9050.98
221_I233_L0.9040.98
373_K378_F0.9010.98
232_L302_M0.8990.98
175_D178_D0.8960.98
167_R427_Q0.8950.98
256_R267_H0.8940.98
381_N384_G0.8930.98
219_V298_R0.8900.98
224_R227_A0.8890.98
123_L127_E0.8870.98
69_G75_G0.8850.98
302_M357_L0.8810.98
198_A201_D0.8790.98
224_R307_T0.8770.98
194_N198_A0.8770.98
381_N385_G0.8760.98
151_A154_A0.8740.98
401_E404_Q0.8720.98
165_H449_S0.8710.98
148_L152_F0.8680.98
157_N161_E0.8660.97
405_Q425_L0.8650.97
176_F179_E0.8650.97
167_R174_I0.8650.97
224_R312_D0.8630.97
75_G121_L0.8630.97
269_I292_E0.8580.97
181_I188_K0.8530.97
44_R71_N0.8520.97
30_R33_A0.8480.97
42_K47_D0.8470.97
247_I281_V0.8420.97
67_F78_V0.8360.97
165_H169_Y0.8350.97
48_Y62_G0.8340.97
407_K411_L0.8310.97
181_I186_D0.8310.97
14_P17_G0.8300.97
24_I103_L0.8300.97
204_R397_E0.8270.97
193_L406_G0.8230.97
303_V334_R0.8210.97
24_I29_A0.8210.97
181_I185_S0.8180.96
128_A132_L0.8170.96
309_D313_P0.8170.96
289_A292_E0.8130.96
129_I133_I0.8120.96
44_R47_D0.8090.96
293_I299_V0.8070.96
8_V103_L0.8070.96
402_H429_N0.8060.96
122_D150_G0.8050.96
51_F93_L0.8020.96
218_K295_Q0.7980.96
34_E40_L0.7950.96
109_G116_F0.7950.96
397_E401_E0.7930.96
62_G83_G0.7910.96
169_Y173_A0.7900.96
128_A131_D0.7900.96
232_L368_L0.7890.96
58_V145_L0.7850.96
218_K292_E0.7840.95
163_L423_L0.7830.95
59_L92_L0.7820.95
403_L426_A0.7800.95
155_R158_H0.7800.95
170_V420_A0.7780.95
95_K138_E0.7770.95
290_W319_E0.7750.95
317_W320_F0.7750.95
331_T355_I0.7690.95
66_W69_G0.7690.95
427_Q431_S0.7680.95
49_L64_A0.7680.95
33_A41_P0.7650.95
36_V51_F0.7650.95
34_E41_P0.7630.95
421_E425_L0.7630.95
221_I289_A0.7630.95
116_F123_L0.7620.95
37_L51_F0.7600.95
303_V343_T0.7600.95
404_Q408_A0.7560.94
224_R316_I0.7550.94
171_E175_D0.7550.94
262_D369_R0.7540.94
425_L429_N0.7520.94
158_H199_D0.7510.94
147_S152_F0.7510.94
306_T339_I0.7500.94
279_D286_I0.7480.94
19_V63_I0.7470.94
106_A109_G0.7450.94
172_A179_E0.7450.94
114_R128_A0.7440.94
75_G118_N0.7410.94
406_G409_Q0.7390.94
174_I179_E0.7370.94
81_L97_I0.7370.94
112_S116_F0.7350.94
400_A407_K0.7340.94
387_L393_L0.7340.94
299_V328_L0.7320.93
11_A78_V0.7320.93
51_F64_A0.7300.93
451_C454_K0.7290.93
222_A299_V0.7290.93
220_V269_I0.7280.93
34_E39_K0.7280.93
10_Q22_L0.7280.93
400_A403_L0.7270.93
146_N150_G0.7270.93
277_A283_R0.7260.93
109_G114_R0.7240.93
396_L399_A0.7240.93
302_M359_A0.7210.93
8_V22_L0.7210.93
192_Q195_D0.7170.93
431_S435_G0.7160.93
110_E115_A0.7150.93
233_L241_A0.7140.93
437_F441_D0.7140.93
119_D123_L0.7130.93
170_V175_D0.7130.93
38_G41_P0.7100.92
64_A81_L0.7100.92
146_N151_A0.7070.92
11_A18_G0.7070.92
428_Q437_F0.7010.92
434_T437_F0.6990.92
13_P16_R0.6970.92
106_A111_F0.6940.92
221_I302_M0.6920.91
160_V427_Q0.6900.91
147_S392_H0.6880.91
170_V174_I0.6880.91
137_S144_A0.6870.91
139_Q142_R0.6850.91
121_L125_Q0.6840.91
357_L365_V0.6840.91
299_V330_I0.6800.91
59_L93_L0.6770.91
137_S265_P0.6760.90
427_Q434_T0.6760.90
51_F96_R0.6760.90
156_V203_V0.6760.90
99_T397_E0.6750.90
345_G356_R0.6740.90
282_E285_G0.6740.90
359_A362_G0.6710.90
149_Q154_A0.6700.90
233_L255_L0.6690.90
341_G344_L0.6690.90
213_L265_P0.6670.90
418_L422_E0.6670.90
128_A147_S0.6670.90
157_N160_V0.6660.90
127_E131_D0.6650.90
313_P317_W0.6640.90
405_Q409_Q0.6640.90
191_A195_D0.6630.90
320_F323_R0.6630.90
165_H445_R0.6610.90
218_K269_I0.6610.90
39_K47_D0.6600.89
119_D127_E0.6600.89
392_H433_I0.6600.89
191_A198_A0.6600.89
313_P316_I0.6590.89
259_I268_I0.6590.89
314_A319_E0.6590.89
140_A143_S0.6580.89
52_K55_D0.6580.89
63_I82_Q0.6570.89
275_R285_G0.6570.89
172_A452_I0.6570.89
288_R291_Q0.6530.89
360_R363_E0.6520.89
384_G388_A0.6520.89
418_L421_E0.6510.89
44_R68_P0.6510.89
6_T103_L0.6510.89
395_A399_A0.6510.89
236_L365_V0.6490.89
300_L368_L0.6480.89
450_F453_G0.6470.88
132_L145_L0.6470.88
167_R420_A0.6460.88
18_G24_I0.6450.88
367_V370_N0.6440.88
168_I172_A0.6440.88
382_M385_G0.6430.88
162_A196_V0.6420.88
388_A393_L0.6400.88
109_G123_L0.6390.88
104_R108_P0.6380.88
111_F115_A0.6380.88
125_Q128_A0.6380.88
386_F389_R0.6360.88
242_A255_L0.6360.88
383_E388_A0.6340.87
86_G93_L0.6330.87
81_L85_G0.6330.87
106_A110_E0.6330.87
5_D27_F0.6300.87
355_I368_L0.6290.87
88_V92_L0.6280.87
202_A366_D0.6270.87
440_D444_G0.6250.87
388_A392_H0.6250.87
238_G362_G0.6250.87
110_E126_A0.6250.87
41_P45_Y0.6240.87
222_A301_F0.6230.87
44_R48_Y0.6230.87
124_A127_E0.6230.87
184_L188_K0.6220.86
24_I79_L0.6210.86
169_Y172_A0.6210.86
278_S283_R0.6200.86
111_F114_R0.6200.86
30_R79_L0.6190.86
385_G388_A0.6180.86
231_S235_A0.6180.86
204_R400_A0.6170.86
432_E438_T0.6170.86
274_L290_W0.6160.86
111_F118_N0.6160.86
171_E177_P0.6150.86
186_D189_I0.6120.86
427_Q442_L0.6110.86
220_V292_E0.6100.85
158_H161_E0.6100.85
301_F330_I0.6100.85
308_T342_E0.6070.85
365_V369_R0.6070.85
281_V288_R0.6060.85
28_K35_T0.6050.85
339_I361_T0.6050.85
395_A398_Q0.6050.85
133_I137_S0.6040.85
12_T15_G0.6020.85
122_D126_A0.6000.84
44_R66_W0.6000.84
137_S141_A0.5990.84
364_G368_L0.5990.84
114_R123_L0.5970.84
421_E427_Q0.5960.84
24_I32_V0.5950.84
86_G89_I0.5950.84
72_S76_E0.5950.84
168_I178_D0.5950.84
38_G50_P0.5950.84
154_A157_N0.5940.84
173_A183_F0.5920.84
382_M386_F0.5900.83
261_I369_R0.5880.83
41_P44_R0.5870.83
25_S76_E0.5860.83
46_A82_Q0.5860.83
163_L426_A0.5860.83
160_V436_E0.5860.83
109_G115_A0.5850.83
240_E288_R0.5840.83
30_R40_L0.5820.83
167_R171_E0.5820.83
220_V289_A0.5820.83
109_G122_D0.5810.83
237_A259_I0.5810.83
58_V61_Q0.5800.82
11_A72_S0.5790.82
46_A49_L0.5770.82
409_Q419_L0.5770.82
169_Y174_I0.5760.82
379_D382_M0.5760.82
227_A274_L0.5750.82
443_L452_I0.5730.82
450_F454_K0.5720.82
173_A177_P0.5720.82
39_K49_L0.5720.82
50_P149_Q0.5720.82
167_R423_L0.5700.81
421_E424_R0.5700.81
19_V82_Q0.5700.81
332_V354_L0.5680.81
431_S434_T0.5680.81
16_R136_S0.5680.81
44_R65_L0.5660.81
152_F155_R0.5660.81
196_V203_V0.5650.81
438_T443_L0.5640.81
121_L126_A0.5640.81
362_G365_V0.5630.81
424_R452_I0.5630.81
289_A293_I0.5630.81
241_A254_V0.5620.80
193_L197_I0.5610.80
124_A128_A0.5610.80
176_F443_L0.5590.80
37_L64_A0.5590.80
385_G389_R0.5580.80
66_W79_L0.5570.80
356_R367_V0.5570.80
204_R393_L0.5560.80
363_E367_V0.5540.80
30_R41_P0.5540.80
40_L49_L0.5530.79
85_G109_G0.5510.79
92_L141_A0.5500.79
353_A375_S0.5490.79
172_A177_P0.5490.79
172_A181_I0.5490.79
409_Q414_W0.5490.79
111_F127_E0.5480.79
61_Q120_K0.5470.79
38_G56_G0.5470.79
344_L356_R0.5460.79
275_R282_E0.5450.78
352_H371_H0.5440.78
115_A120_K0.5440.78
170_V178_D0.5430.78
126_A130_A0.5420.78
109_G117_L0.5420.78
115_A118_N0.5420.78
415_A418_L0.5410.78
152_F156_V0.5410.78
124_A129_I0.5400.78
256_R269_I0.5390.78
340_T344_L0.5390.78
76_E118_N0.5380.78
160_V431_S0.5370.77
206_E209_Q0.5350.77
392_H431_S0.5350.77
340_T345_G0.5350.77
106_A123_L0.5350.77
173_A176_F0.5350.77
61_Q64_A0.5340.77
306_T340_T0.5340.77
294_E328_L0.5340.77
98_L103_L0.5340.77
266_L376_M0.5330.77
116_F122_D0.5330.77
201_D204_R0.5330.77
138_E142_R0.5310.77
36_V39_K0.5300.76
180_E185_S0.5300.76
127_E135_A0.5300.76
171_E176_F0.5280.76
104_R111_F0.5280.76
218_K297_D0.5280.76
109_G118_N0.5280.76
64_A79_L0.5280.76
323_R327_K0.5280.76
207_A393_L0.5270.76
150_G176_F0.5260.76
77_D80_E0.5250.76
85_G89_I0.5240.76
245_T280_E0.5240.76
12_T17_G0.5230.76
286_I290_W0.5230.76
132_L150_G0.5230.76
370_N373_K0.5210.75
200_L400_A0.5200.75
84_H89_I0.5170.75
319_E448_S0.5170.75
366_D370_N0.5170.75
110_E244_V0.5160.75
408_A411_L0.5160.75
122_D153_S0.5160.75
95_K99_T0.5150.74
67_F75_G0.5150.74
224_R303_V0.5150.74
76_E84_H0.5130.74
380_T384_G0.5130.74
16_R87_P0.5120.74
261_I264_M0.5120.74
91_D95_K0.5120.74
131_D392_H0.5110.74
211_S393_L0.5100.74
431_S442_L0.5100.74
143_S388_A0.5090.74
165_H168_I0.5090.74
255_L267_H0.5080.73
61_Q145_L0.5080.73
236_L259_I0.5060.73
432_E435_G0.5060.73
118_N122_D0.5050.73
171_E446_I0.5050.73
12_T16_R0.5030.73
304_D335_N0.5030.73
182_D187_G0.5030.73
104_R114_R0.5010.72
227_A289_A0.5000.72
13_P18_G0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1xzpA 4 0.978 100 0.172 Contact Map
3geeA 2 0.9075 100 0.175 Contact Map
3gehA 2 0.9405 100 0.176 Contact Map
2qtfA 1 0.6322 100 0.72 Contact Map
3j65o 1 0.7026 100 0.722 Contact Map
4kjzA 1 0.6057 100 0.727 Contact Map
3j4jA 1 0.6101 100 0.728 Contact Map
4b43A 1 0.5903 100 0.735 Contact Map
2e87A 1 0.7225 100 0.743 Contact Map
2qm8A 2 0.5661 100 0.743 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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