GREMLIN Database
HFLX - GTPase HflX
UniProt: P25519 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10437
Length: 426 (387)
Sequences: 3434 (1921)
Seq/√Len: 97.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
63_A95_L4.0201.00
70_V98_C3.6681.00
130_R175_Q3.6341.00
34_V79_L3.6131.00
58_V66_I3.5941.00
281_L315_V3.2711.00
63_A92_L3.2471.00
49_R53_H2.8601.00
236_L248_V2.8461.00
31_E44_V2.8331.00
201_S277_A2.8021.00
28_Q44_V2.7611.00
284_I314_L2.7131.00
238_R246_E2.6931.00
62_K65_E2.6701.00
125_E170_R2.5731.00
243_D358_T2.5681.00
32_S35_S2.5451.00
78_V96_C2.4801.00
45_I66_I2.3981.00
70_V78_V2.3521.00
34_V39_V2.3341.00
82_H258_H2.3241.00
216_R350_I2.2921.00
356_A359_E2.2901.00
43_Q69_A2.2531.00
67_A71_K2.2461.00
200_V247_T2.2131.00
17_Y48_S2.2071.00
12_V75_A2.1911.00
299_N312_T2.1601.00
236_L250_A2.1431.00
122_L174_I2.1341.00
36_S114_R2.1101.00
45_I69_A2.0661.00
14_V58_V2.0481.00
295_I314_L2.0021.00
11_A39_V1.9941.00
212_T344_A1.9911.00
315_V353_L1.9881.00
92_L96_C1.9881.00
288_D294_N1.9811.00
265_A268_K1.9711.00
14_V80_F1.9401.00
281_L353_L1.8921.00
382_R386_L1.8841.00
313_L356_A1.8761.00
109_D128_Q1.8661.00
203_V280_L1.8631.00
303_E308_H1.8301.00
223_Y227_Q1.8251.00
261_H301_V1.8001.00
162_T166_L1.7891.00
173_Q177_R1.7771.00
356_A360_R1.7571.00
179_E182_E1.7391.00
11_A77_V1.7301.00
78_V98_C1.7151.00
140_W159_Q1.7151.00
279_L357_L1.7141.00
315_V340_V1.7101.00
182_E272_Q1.7031.00
384_Y392_E1.6971.00
290_R293_E1.6921.00
193_I276_Q1.6751.00
319_I341_W1.6701.00
67_A95_L1.6631.00
119_E185_R1.6461.00
140_W144_E1.6431.00
36_S227_Q1.6401.00
296_E300_T1.6241.00
284_I295_I1.6201.00
58_V80_F1.6191.00
211_S222_V1.5991.00
146_Q152_L1.5961.00
125_E129_L1.5931.00
171_I175_Q1.5801.00
300_T304_E1.5711.00
140_W143_L1.5671.00
70_V96_C1.5661.00
371_R398_G1.5651.00
182_E268_K1.5651.00
287_A321_M1.5651.00
215_N224_A1.5531.00
286_A316_M1.5501.00
216_R347_G1.5391.00
8_G40_E1.5261.00
185_R272_Q1.5211.00
15_H27_L1.5071.00
222_V235_T1.4881.00
313_L360_R1.4861.00
12_V69_A1.4751.00
118_H177_R1.4691.00
57_F82_H1.4681.00
282_H298_V1.4531.00
275_R306_D1.4491.00
380_R392_E1.4441.00
142_H159_Q1.4381.00
9_E99_R1.4371.00
346_T349_G1.4331.00
126_L171_I1.4181.00
63_A96_C1.3990.99
316_M341_W1.3980.99
323_E326_E1.3870.99
64_V68_E1.3870.99
34_V106_L1.3740.99
53_H60_E1.3680.99
23_D46_T1.3670.99
239_I249_L1.3660.99
184_Q187_Q1.3630.99
223_Y230_A1.3520.99
172_V176_S1.3510.99
218_T239_I1.3460.99
189_R272_Q1.3440.99
299_N314_L1.3360.99
182_E269_A1.3240.99
212_T342_L1.3190.99
12_V43_Q1.3170.99
140_W147_K1.3020.99
28_Q31_E1.3000.99
262_D304_E1.2850.99
240_D246_E1.2840.99
56_Y63_A1.2830.99
200_V281_L1.2750.99
203_V302_L1.2690.99
64_V95_L1.2660.99
138_R147_K1.2660.99
286_A291_V1.2630.99
147_K152_L1.2590.99
30_F79_L1.2570.99
373_P376_E1.2550.99
69_A73_T1.2540.99
349_G352_Q1.2530.99
295_I299_N1.2480.99
10_Q40_E1.2470.99
199_T248_V1.2430.99
39_V76_S1.2340.99
291_V316_M1.2240.99
42_L73_T1.2130.99
122_L181_V1.2130.99
36_S256_I1.2090.98
133_A168_R1.1950.98
338_N356_A1.1840.98
37_A109_D1.1840.98
279_L313_L1.1830.98
241_V247_T1.1830.98
187_Q190_Q1.1640.98
70_V75_A1.1630.98
239_I247_T1.1610.98
43_Q75_A1.1590.98
374_P398_G1.1580.98
288_D291_V1.1530.98
15_H26_D1.1500.98
114_R223_Y1.1470.98
200_V279_L1.1390.98
307_A310_I1.1370.98
315_V342_L1.1360.98
355_Q359_E1.1360.98
39_V79_L1.1350.98
58_V63_A1.1330.98
261_H264_V1.1280.98
138_R142_H1.1220.98
39_V109_D1.1180.97
138_R141_T1.1150.97
226_D321_M1.1130.97
68_E71_K1.1070.97
130_R262_D1.1050.97
282_H295_I1.1020.97
202_L214_F1.0980.97
9_E39_V1.0920.97
284_I291_V1.0910.97
128_Q155_P1.0910.97
42_L75_A1.0870.97
43_Q73_T1.0760.97
36_S228_L1.0720.97
184_Q188_G1.0720.97
376_E379_L1.0710.97
68_E72_A1.0690.97
128_Q132_L1.0600.96
13_L30_F1.0540.96
146_Q159_Q1.0530.96
14_V66_I1.0480.96
144_E152_L1.0480.96
77_V99_R1.0430.96
313_L357_L1.0410.96
182_E265_A1.0390.96
295_I316_M1.0370.96
367_Q390_E1.0330.96
395_E398_G1.0280.96
120_G155_P1.0260.96
128_Q160_L1.0210.96
119_E181_V1.0180.96
34_V41_A1.0160.96
207_N226_D1.0150.96
157_E165_R1.0110.95
112_A155_P1.0100.95
381_S385_Q1.0050.95
138_R152_L1.0050.95
353_L357_L1.0050.95
16_I47_G1.0040.95
10_Q74_G1.0030.95
292_Q296_E1.0020.95
372_L379_L0.9990.95
297_A301_V0.9990.95
67_A97_E0.9940.95
91_N94_R0.9930.95
130_R171_I0.9900.95
129_L167_L0.9880.95
144_E147_K0.9860.95
242_A358_T0.9810.95
69_A75_A0.9780.95
109_D153_R0.9780.95
282_H312_T0.9710.94
180_R183_K0.9680.94
150_I155_P0.9680.94
52_P57_F0.9640.94
31_E35_S0.9600.94
152_L162_T0.9590.94
39_V77_V0.9560.94
16_I52_P0.9550.94
71_K97_E0.9540.94
147_K150_I0.9500.94
39_V150_I0.9500.94
66_I96_C0.9480.94
190_Q194_K0.9480.94
152_L155_P0.9450.93
139_G142_H0.9420.93
24_M28_Q0.9410.93
282_H288_D0.9390.93
112_A128_Q0.9370.93
153_R160_L0.9310.93
352_Q355_Q0.9310.93
176_S179_E0.9300.93
191_S194_K0.9260.93
81_D258_H0.9200.93
342_L350_I0.9190.92
371_R395_E0.9180.92
293_E296_E0.9180.92
287_A322_L0.9140.92
140_W166_L0.9130.92
227_Q230_A0.9120.92
159_Q166_L0.9120.92
301_V305_I0.9110.92
11_A79_L0.9050.92
291_V295_I0.9050.92
144_E159_Q0.9030.92
120_G234_P0.9020.92
225_A230_A0.9020.92
197_V248_V0.9010.92
172_V175_Q0.8980.92
94_R97_E0.8970.92
146_Q158_T0.8940.91
26_D258_H0.8870.91
372_L376_E0.8850.91
360_R363_G0.8810.91
325_F328_R0.8710.90
38_G113_Q0.8680.90
268_K304_E0.8660.90
161_E165_R0.8620.90
183_K187_Q0.8610.90
36_S109_D0.8600.90
83_A262_D0.8570.90
37_A112_A0.8570.90
374_P394_M0.8540.89
387_Q392_E0.8510.89
214_F249_L0.8510.89
203_V274_T0.8490.89
274_T277_A0.8380.89
340_V356_A0.8380.89
12_V66_I0.8320.88
13_L31_E0.8310.88
338_N360_R0.8310.88
144_E150_I0.8300.88
142_H166_L0.8280.88
138_R159_Q0.8270.88
347_G350_I0.8260.88
214_F297_A0.8250.88
314_L339_R0.8210.87
39_V128_Q0.8200.87
109_D112_A0.8170.87
146_Q153_R0.8160.87
136_L160_L0.8150.87
146_Q150_I0.8150.87
37_A128_Q0.8150.87
217_I354_F0.8150.87
374_P395_E0.8130.87
36_S223_Y0.8130.87
185_R266_A0.8120.87
67_A96_C0.8120.87
143_L163_D0.8090.87
60_E64_V0.8090.87
274_T280_L0.8050.86
371_R374_P0.8050.86
24_M44_V0.8030.86
326_E329_I0.8030.86
142_H145_R0.8000.86
370_L379_L0.8000.86
79_L106_L0.7990.86
383_F387_Q0.7960.86
234_P249_L0.7950.86
99_R128_Q0.7920.86
120_G266_A0.7860.85
239_I357_L0.7840.85
15_H23_D0.7800.85
300_T303_E0.7790.85
245_G362_S0.7780.85
178_L181_V0.7760.84
36_S225_A0.7750.84
99_R109_D0.7740.84
186_E193_I0.7730.84
200_V357_L0.7710.84
244_V358_T0.7690.84
47_G62_K0.7670.84
138_R163_D0.7670.84
202_L213_L0.7610.83
321_M345_Q0.7610.83
32_S257_R0.7600.83
45_I75_A0.7580.83
384_Y389_I0.7560.83
144_E153_R0.7560.83
324_D327_P0.7550.83
27_L30_F0.7550.83
35_S41_A0.7540.83
169_N173_Q0.7530.83
101_I106_L0.7530.83
169_N172_V0.7530.83
56_Y60_E0.7520.82
137_V140_W0.7500.82
25_E290_R0.7490.82
189_R273_E0.7450.82
140_W145_R0.7430.82
166_L169_N0.7430.82
117_T120_G0.7410.82
198_P361_L0.7390.81
296_E299_N0.7370.81
144_E166_L0.7310.81
10_Q42_L0.7270.80
39_V99_R0.7230.80
25_E288_D0.7210.80
89_E105_G0.7200.80
351_P355_Q0.7140.79
211_S224_A0.7140.79
31_E41_A0.7130.79
167_L171_I0.7130.79
301_V304_E0.7110.79
177_R265_A0.7100.79
242_A354_F0.7090.79
245_G358_T0.7090.79
138_R143_L0.7070.78
15_H258_H0.7040.78
119_E266_A0.7010.78
27_L44_V0.6960.77
32_S36_S0.6950.77
355_Q358_T0.6940.77
57_F80_F0.6910.77
140_W155_P0.6910.77
136_L164_R0.6900.77
64_V67_A0.6860.76
202_L283_V0.6860.76
208_A266_A0.6850.76
74_G180_R0.6840.76
141_T144_E0.6780.76
218_T221_R0.6770.75
323_E328_R0.6760.75
94_R98_C0.6750.75
159_Q163_D0.6720.75
36_S202_L0.6700.75
142_H146_Q0.6680.74
286_A322_L0.6670.74
143_L159_Q0.6660.74
56_Y95_L0.6630.74
191_S195_A0.6630.74
12_V45_I0.6620.74
47_G59_G0.6620.74
37_A113_Q0.6610.74
13_L44_V0.6590.73
327_P348_A0.6580.73
284_I316_M0.6580.73
99_R187_Q0.6580.73
372_L377_G0.6540.73
322_L327_P0.6540.73
144_E148_G0.6530.73
151_G155_P0.6500.72
188_G265_A0.6490.72
93_E99_R0.6480.72
148_G152_L0.6480.72
132_L139_G0.6460.72
316_M339_R0.6460.72
28_Q321_M0.6440.72
90_R93_E0.6420.71
67_A70_V0.6410.71
12_V70_V0.6410.71
9_E128_Q0.6390.71
384_Y394_M0.6390.71
297_A300_T0.6390.71
40_E44_V0.6380.71
384_Y387_Q0.6380.71
370_L383_F0.6340.71
9_E76_S0.6320.70
200_V360_R0.6320.70
207_N225_A0.6290.70
126_L174_I0.6290.70
140_W152_L0.6280.70
245_G365_V0.6270.70
159_Q215_N0.6250.69
26_D257_R0.6250.69
316_M336_K0.6250.69
128_Q150_I0.6250.69
158_T162_T0.6220.69
371_R397_D0.6210.69
342_L348_A0.6170.68
112_A153_R0.6150.68
36_S257_R0.6150.68
32_S226_D0.6130.68
84_L277_A0.6130.68
176_S348_A0.6120.68
235_T384_Y0.6090.67
247_T357_L0.6090.67
154_G161_E0.6090.67
245_G361_L0.6080.67
99_R155_P0.6080.67
277_A307_A0.6080.67
101_I105_G0.6060.67
216_R345_Q0.6060.67
283_V342_L0.6060.67
175_Q265_A0.6050.67
233_D298_V0.6040.67
119_E272_Q0.6040.67
233_D263_L0.6040.67
279_L360_R0.6020.67
160_L163_D0.6010.66
154_G157_E0.6010.66
299_N303_E0.5980.66
26_D30_F0.5970.66
157_E161_E0.5960.66
175_Q179_E0.5950.66
66_I70_V0.5920.65
137_V148_G0.5910.65
67_A98_C0.5910.65
144_E155_P0.5910.65
392_E398_G0.5900.65
105_G134_T0.5890.65
40_E74_G0.5890.65
380_R384_Y0.5870.65
145_R272_Q0.5870.65
377_G383_F0.5870.65
261_H304_E0.5860.65
117_T121_K0.5860.65
219_E378_R0.5860.65
214_F222_V0.5820.64
275_R310_I0.5820.64
27_L46_T0.5810.64
59_G84_L0.5800.64
179_E183_K0.5790.64
284_I299_N0.5760.63
57_F85_S0.5760.63
30_F80_F0.5750.63
211_S249_L0.5750.63
221_R225_A0.5750.63
137_V164_R0.5750.63
15_H18_F0.5740.63
17_Y23_D0.5710.63
315_V350_I0.5710.63
128_Q162_T0.5700.62
377_G380_R0.5700.62
342_L346_T0.5700.62
156_G165_R0.5690.62
37_A150_I0.5680.62
377_G381_S0.5680.62
199_T276_Q0.5680.62
140_W163_D0.5670.62
28_Q194_K0.5670.62
214_F224_A0.5670.62
390_E393_W0.5660.62
59_G62_K0.5660.62
76_S269_A0.5650.62
45_I73_T0.5640.62
389_I392_E0.5640.62
213_L342_L0.5630.61
327_P341_W0.5630.61
134_T214_F0.5630.61
272_Q276_Q0.5630.61
22_K293_E0.5610.61
186_E363_G0.5610.61
132_L160_L0.5600.61
89_E142_H0.5580.61
224_A227_Q0.5570.61
83_A104_T0.5560.61
66_I113_Q0.5560.61
120_G215_N0.5560.61
346_T351_P0.5560.61
309_E396_E0.5550.60
216_R224_A0.5550.60
105_G160_L0.5540.60
194_K363_G0.5530.60
214_F250_A0.5520.60
50_K300_T0.5510.60
178_L265_A0.5510.60
295_I298_V0.5500.60
239_I354_F0.5490.60
10_Q76_S0.5470.59
378_R385_Q0.5460.59
306_D310_I0.5460.59
138_R144_E0.5450.59
374_P377_G0.5450.59
94_R321_M0.5430.59
142_H152_L0.5430.59
214_F236_L0.5420.59
351_P354_F0.5410.58
241_V244_V0.5410.58
350_I354_F0.5410.58
136_L165_R0.5400.58
180_R184_Q0.5400.58
276_Q345_Q0.5390.58
79_L162_T0.5380.58
108_L215_N0.5370.58
71_K98_C0.5370.58
15_H81_D0.5370.58
324_D328_R0.5370.58
220_A234_P0.5350.58
224_A269_A0.5340.57
230_A263_L0.5330.57
302_L307_A0.5330.57
159_Q177_R0.5330.57
30_F41_A0.5320.57
336_K339_R0.5310.57
133_A171_I0.5300.57
382_R385_Q0.5300.57
172_V180_R0.5290.57
32_S265_A0.5290.57
29_E33_L0.5290.57
80_F84_L0.5280.57
371_R393_W0.5270.56
126_L298_V0.5270.56
179_E359_E0.5270.56
23_D81_D0.5260.56
370_L394_M0.5250.56
77_V158_T0.5250.56
285_D318_K0.5250.56
110_I178_L0.5250.56
26_D32_S0.5240.56
153_R162_T0.5220.56
185_R234_P0.5210.56
42_L76_S0.5210.56
128_Q153_R0.5210.56
10_Q75_A0.5210.56
315_V357_L0.5210.56
15_H82_H0.5200.55
380_R389_I0.5200.55
286_A319_I0.5190.55
145_R148_G0.5190.55
391_K395_E0.5180.55
129_L171_I0.5180.55
105_G158_T0.5180.55
199_T305_I0.5170.55
176_S180_R0.5160.55
101_I109_D0.5160.55
375_Q382_R0.5150.55
184_Q224_A0.5140.55
322_L326_E0.5130.54
101_I112_A0.5120.54
176_S300_T0.5120.54
202_L222_V0.5120.54
160_L164_R0.5110.54
13_L16_I0.5090.54
378_R381_S0.5080.54
203_V307_A0.5080.54
116_R233_D0.5080.54
225_A228_L0.5080.54
345_Q391_K0.5070.54
266_A396_E0.5070.54
105_G139_G0.5060.53
146_Q155_P0.5050.53
354_F358_T0.5040.53
346_T359_E0.5030.53
107_I157_E0.5030.53
140_W160_L0.5030.53
57_F188_G0.5010.53
85_S88_Q0.5010.53
379_L386_L0.5000.53
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qtfA 1 0.7042 100 0.369 Contact Map
3geeA 2 0.8192 100 0.711 Contact Map
3j65o 1 0.7441 100 0.711 Contact Map
1xzpA 4 0.892 100 0.725 Contact Map
3gehA 2 0.8521 100 0.744 Contact Map
2e87A 1 0.7958 100 0.762 Contact Map
3j4jA 1 0.6549 100 0.779 Contact Map
4kjzA 1 0.6667 100 0.788 Contact Map
2qm8A 2 0.5939 100 0.789 Contact Map
4xc8A 2 0.9202 100 0.79 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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