GREMLIN Database
ACON1 - Aconitate hydratase 1
UniProt: P25516 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11325
Length: 891 (871)
Sequences: 2126 (875)
Seq/√Len: 29.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
575_H581_P5.5311.00
666_A750_I5.1231.00
288_Y362_T5.0581.00
452_K488_Y4.7301.00
278_H361_S4.7241.00
319_I344_A4.7171.00
486_T490_D4.5871.00
741_H760_E4.4611.00
477_S499_Y4.4091.00
785_P811_I4.3771.00
741_H744_D4.3271.00
328_R334_E4.1321.00
322_V325_D4.0411.00
258_L267_L4.0071.00
253_K364_E3.9641.00
341_E345_K3.9301.00
452_K456_T3.8271.00
770_K796_E3.7321.00
490_D495_N3.7111.00
576_D580_D3.6261.00
517_T521_K3.5451.00
453_K593_E3.4681.00
731_V734_V3.4231.00
455_V488_Y3.3931.00
470_A502_T3.3311.00
259_R262_I3.3131.00
849_V863_C3.2991.00
224_L314_C3.2961.00
853_R859_E3.2451.00
87_L180_C3.0531.00
713_H717_M3.0411.00
136_F512_P2.9521.00
456_T488_Y2.9491.00
847_V863_C2.9361.00
274_M363_L2.9191.00
457_L576_D2.9191.00
453_K456_T2.8861.00
661_G834_D2.8831.00
250_V361_S2.8101.00
817_P846_T2.8061.00
203_A339_L2.7921.00
664_I833_I2.7821.00
768_A795_A2.6561.00
124_D171_S2.6521.00
60_E64_H2.6471.00
488_Y491_E2.6401.00
374_L389_V2.6321.00
851_L861_V2.6261.00
741_H756_R2.6201.00
148_L151_E2.5951.00
849_V861_V2.5921.00
516_E543_L2.5831.00
109_R642_L2.5710.99
834_D852_T2.5670.99
29_A34_D2.5430.99
771_E774_S2.5230.99
527_G564_M2.4970.99
250_V360_T2.4930.99
739_T753_A2.4730.99
729_E822_R2.4700.99
29_A36_T2.4620.99
11_D27_L2.4470.99
746_D756_R2.4000.99
371_E387_P2.3950.99
563_N566_I2.3650.99
389_V564_M2.3110.99
250_V278_H2.3060.99
274_M365_L2.3030.99
105_E642_L2.2960.99
293_D351_R2.2630.99
734_V747_V2.2510.99
158_V634_Q2.2510.99
385_A388_D2.2380.99
135_R144_E2.2360.99
796_E821_T2.2180.98
817_P820_V2.2120.98
567_N570_S2.2070.98
133_V468_S2.2050.98
751_Y755_M2.2010.98
455_V491_E2.1990.98
612_E615_E2.1990.98
37_R358_I2.1940.98
392_A548_W2.1550.98
273_Q277_K2.1530.98
431_A502_T2.1440.98
146_V176_G2.1420.98
846_T862_P2.1420.98
660_H834_D2.1330.98
470_A497_V2.0930.98
658_D837_D2.0850.98
189_G223_V2.0680.98
683_I687_S2.0650.97
668_L726_I2.0630.97
177_T613_V2.0480.97
792_V835_I2.0320.97
310_Y315_G2.0300.97
446_A553_P2.0240.97
729_E823_K2.0130.97
142_F496_L1.9980.97
446_A594_I1.9870.97
450_L453_K1.9780.97
189_G218_I1.9760.97
273_Q383_R1.9740.97
520_K543_L1.9730.97
641_R714_E1.9700.97
371_E385_A1.9690.97
595_A598_V1.9660.97
592_Q596_R1.9600.97
374_L550_A1.9590.97
388_D391_K1.9530.96
307_S310_Y1.9490.96
748_V753_A1.9440.96
765_A833_I1.9350.96
699_E702_D1.9300.96
194_S201_W1.9190.96
150_M617_T1.9100.96
366_D369_D1.9080.96
144_E147_R1.8990.96
836_G850_T1.8980.96
22_Y346_A1.8960.96
667_M729_E1.8890.96
390_P571_E1.8840.96
481_A486_T1.8740.96
252_F274_M1.8730.95
307_S315_G1.8710.95
744_D756_R1.8700.95
732_P738_M1.8680.95
11_D24_S1.8640.95
165_Q627_R1.8640.95
61_E64_H1.8550.95
748_V756_R1.8480.95
851_L859_E1.8460.95
253_K356_E1.8390.95
848_P860_V1.8260.95
706_Y722_A1.8250.95
69_W360_T1.8210.95
192_V203_A1.8190.95
444_L469_L1.8170.95
497_V502_T1.8170.95
878_N887_R1.8170.95
453_K457_L1.8080.95
821_T824_T1.8070.95
664_I667_M1.8050.94
767_I833_I1.8020.94
297_L322_V1.7980.94
389_V558_Y1.7960.94
15_A18_K1.7830.94
270_T373_S1.7730.94
705_S708_S1.7630.94
659_I662_A1.7590.94
850_T860_V1.7560.94
445_M597_A1.7500.93
642_L647_D1.7480.93
667_M822_R1.7370.93
140_E144_E1.7370.93
16_K335_D1.7160.93
618_A622_G1.7050.93
720_T784_G1.7050.93
684_K690_G1.6970.92
23_Y202_I1.6840.92
15_A20_Y1.6680.92
450_L457_L1.6530.91
848_P862_P1.6470.91
834_D850_T1.6470.91
161_K625_V1.6450.91
373_S383_R1.6420.91
142_F146_V1.6420.91
744_D760_E1.6410.91
450_L557_A1.6410.91
321_A325_D1.6400.91
478_D609_E1.6340.91
312_A315_G1.6300.91
830_E854_A1.6270.91
852_T858_Q1.6230.91
663_R762_T1.6220.91
453_K590_S1.6190.90
727_R735_E1.6180.90
748_V752_D1.6150.90
133_V431_A1.5990.90
505_I680_A1.5930.90
731_V740_R1.5900.90
714_E717_M1.5880.90
14_Q17_D1.5830.89
379_R382_D1.5800.89
756_R760_E1.5740.89
756_R759_Q1.5630.89
487_P490_D1.5620.89
107_V112_G1.5590.89
767_I822_R1.5590.89
381_Q671_S1.5510.88
53_Q63_I1.5430.88
248_D361_S1.5340.88
867_I876_Y1.5330.88
691_R695_G1.5320.88
394_A565_N1.5290.88
118_N169_R1.5290.88
457_L582_V1.5240.88
365_L369_D1.5200.87
717_M755_M1.5190.87
767_I851_L1.5180.87
617_T621_K1.5130.87
321_A341_E1.5130.87
615_E621_K1.5130.87
731_V747_V1.5040.87
64_H68_G1.5030.87
828_T853_R1.5020.87
430_A494_F1.4930.86
687_S706_Y1.4870.86
575_H579_G1.4840.86
89_Q707_G1.4770.86
623_I626_T1.4750.86
519_I541_H1.4680.85
365_L370_V1.4670.85
253_K288_Y1.4640.85
812_L876_Y1.4630.85
194_S203_A1.4630.85
457_L580_D1.4610.85
390_P567_N1.4580.85
260_E591_A1.4560.85
316_F319_I1.4560.85
11_D22_Y1.4540.85
815_E864_R1.4520.85
853_R857_S1.4510.85
124_D190_K1.4430.84
334_E338_E1.4270.84
741_H748_V1.4190.83
16_K338_E1.4180.83
478_D608_K1.4140.83
740_R830_E1.4070.83
159_F163_G1.4040.83
767_I816_F1.4010.83
450_L590_S1.3940.82
190_K193_W1.3870.82
292_L351_R1.3790.82
519_I526_V1.3720.81
523_D545_K1.3700.81
668_L750_I1.3650.81
494_F559_A1.3620.81
832_K852_T1.3610.81
667_M823_K1.3520.80
49_L63_I1.3490.80
483_A597_A1.3480.80
596_R600_Q1.3480.80
190_K336_Q1.3480.80
482_K602_S1.3480.80
658_D836_G1.3450.80
426_A565_N1.3400.80
738_M749_S1.3320.79
478_D481_A1.3300.79
483_A486_T1.3300.79
344_A350_W1.3260.79
525_T546_T1.3230.79
117_V889_M1.3220.79
429_I544_V1.3220.79
445_M598_V1.3200.79
115_A629_D1.3190.79
601_V606_F1.3110.78
455_V487_P1.3110.78
143_E147_R1.3100.78
452_K455_V1.3000.78
253_K290_D1.2960.77
754_A758_K1.2940.77
22_Y203_A1.2920.77
382_D671_S1.2910.77
874_T877_Q1.2910.77
109_R648_E1.2850.77
665_L790_I1.2800.77
428_V544_V1.2770.76
653_P878_N1.2730.76
667_M767_I1.2720.76
734_V738_M1.2700.76
766_V790_I1.2700.76
741_H762_T1.2680.76
324_L337_V1.2670.76
146_V150_M1.2670.76
878_N884_Y1.2610.75
518_A522_S1.2610.75
817_P862_P1.2610.75
191_A327_M1.2600.75
307_S312_A1.2590.75
14_Q19_T1.2590.75
133_V497_V1.2480.75
134_D152_R1.2400.74
298_A329_L1.2370.74
486_T496_L1.2340.74
396_S548_W1.2330.74
846_T864_R1.2320.74
21_H200_E1.2280.73
393_F548_W1.2240.73
74_H248_D1.2210.73
658_D838_L1.2200.73
304_A315_G1.2180.73
135_R141_A1.2140.73
730_M742_L1.2110.72
727_R733_G1.1990.72
820_V824_T1.1980.72
381_Q774_S1.1900.71
444_L528_A1.1870.71
694_Q700_R1.1870.71
338_E342_K1.1830.71
154_H158_V1.1810.70
461_R467_A1.1800.70
663_R832_K1.1770.70
828_T854_A1.1720.70
24_S347_Q1.1660.69
826_G853_R1.1660.69
774_S785_P1.1610.69
15_A342_K1.1610.69
867_I873_L1.1550.69
604_E608_K1.1540.69
89_Q720_T1.1510.68
406_K409_Q1.1500.68
513_D517_T1.1490.68
487_P491_E1.1480.68
558_Y563_N1.1470.68
333_S336_Q1.1470.68
685_P690_G1.1410.68
412_D421_Q1.1400.68
29_A32_L1.1380.68
342_K346_A1.1360.67
516_E520_K1.1360.67
310_Y316_F1.1360.67
815_E866_R1.1300.67
420_Y515_I1.1260.67
135_R138_D1.1250.67
739_T750_I1.1240.67
105_E630_T1.1240.67
563_N571_E1.1240.67
260_E592_Q1.1230.66
430_A559_A1.1220.66
667_M730_M1.1210.66
729_E821_T1.1200.66
743_P748_V1.1190.66
691_R749_S1.1180.66
755_M758_K1.1170.66
692_Y714_E1.1110.66
474_K609_E1.1110.66
575_H580_D1.1090.65
566_I572_P1.1090.65
143_E619_E1.1090.65
566_I571_E1.1090.65
684_K687_S1.1070.65
91_F94_V1.1000.65
560_L587_I1.0990.65
259_R371_E1.0980.65
392_A396_S1.0970.65
257_K294_S1.0950.64
384_V396_S1.0940.64
453_K587_I1.0940.64
18_K335_D1.0900.64
80_A243_S1.0860.64
248_D360_T1.0830.64
57_S82_R1.0750.63
92_T505_I1.0670.62
91_F720_T1.0650.62
427_V529_V1.0640.62
749_S752_D1.0610.62
114_T815_E1.0600.62
785_P788_L1.0560.62
461_R492_L1.0530.61
216_T315_G1.0530.61
62_D77_R1.0500.61
456_T487_P1.0490.61
743_P756_R1.0470.61
221_L297_L1.0460.61
668_L672_V1.0440.61
642_L645_F1.0400.60
100_L167_F1.0370.60
374_L384_V1.0370.60
304_A312_A1.0360.60
732_P747_V1.0350.60
429_I508_S1.0340.60
244_M869_T1.0320.60
220_G304_A1.0300.60
91_F707_G1.0300.60
107_V889_M1.0290.60
255_T364_E1.0290.60
685_P694_Q1.0260.59
88_M180_C1.0250.59
185_L301_A1.0240.59
40_K359_F1.0210.59
268_V616_G1.0200.59
194_S339_L1.0200.59
40_K354_G1.0180.59
452_K487_P1.0180.59
171_S614_F1.0180.59
54_D58_V1.0170.59
411_V522_S1.0160.59
328_R341_E1.0140.58
576_D582_V1.0130.58
794_I863_C1.0130.58
850_T858_Q1.0130.58
135_R140_E1.0110.58
24_S346_A1.0090.58
412_D419_Q1.0080.58
20_Y203_A1.0080.58
455_V492_L1.0080.58
12_T19_T1.0070.58
603_T607_R1.0020.58
664_I767_I1.0020.58
658_D839_Q1.0010.57
66_L246_I1.0010.57
304_A307_S1.0010.57
490_D496_L0.9990.57
683_I738_M0.9990.57
287_F594_I0.9990.57
731_V738_M0.9960.57
25_L35_I0.9920.57
13_L342_K0.9920.57
786_R791_R0.9890.57
650_Q654_A0.9880.56
21_H202_I0.9870.56
185_L218_I0.9870.56
569_A585_K0.9870.56
557_A584_L0.9860.56
389_V548_W0.9860.56
48_N464_W0.9850.56
428_V526_V0.9850.56
381_Q705_S0.9840.56
252_F365_L0.9840.56
133_V502_T0.9840.56
390_P565_N0.9820.56
820_V862_P0.9820.56
628_S632_G0.9820.56
374_L564_M0.9810.56
327_M340_V0.9770.56
692_Y713_H0.9760.55
278_H362_T0.9750.55
147_R619_E0.9610.54
105_E109_R0.9590.54
765_A785_P0.9570.54
336_Q339_L0.9560.54
107_V116_K0.9510.54
686_D690_G0.9490.53
250_V304_A0.9490.53
691_R694_Q0.9480.53
52_W82_R0.9480.53
815_E868_D0.9460.53
92_T680_A0.9440.53
767_I794_I0.9410.53
110_L887_R0.9380.53
44_V221_L0.9380.53
450_L572_P0.9350.52
133_V498_G0.9340.52
819_G824_T0.9340.52
144_E148_L0.9340.52
150_M548_W0.9340.52
45_L83_P0.9320.52
271_V365_L0.9290.52
486_T495_N0.9280.52
482_K605_M0.9240.51
86_V209_V0.9240.51
618_A621_K0.9190.51
319_I350_W0.9170.51
450_L584_L0.9170.51
649_M887_R0.9160.51
796_E823_K0.9160.51
393_F546_T0.9140.51
295_L299_D0.9130.51
307_S774_S0.9130.51
283_K361_S0.9130.51
561_A566_I0.9120.50
666_A726_I0.9110.50
685_P700_R0.9100.50
102_A643_S0.9070.50
49_L53_Q0.9050.50
659_I835_I0.9040.50
560_L573_I0.9030.50
653_P887_R0.9000.50
384_V548_W0.8990.49
414_V419_Q0.8990.49
626_T632_G0.8990.49
107_V117_V0.8980.49
765_A792_V0.8970.49
842_Q845_A0.8950.49
252_F370_V0.8940.49
563_N568_L0.8920.49
641_R712_N0.8920.49
616_G621_K0.8900.49
134_D148_L0.8890.49
851_L863_C0.8880.49
726_I749_S0.8870.48
448_G469_L0.8840.48
163_G268_V0.8820.48
577_R580_D0.8810.48
350_W464_W0.8810.48
461_R464_W0.8800.48
595_A599_E0.8800.48
491_E495_N0.8800.48
460_K491_E0.8790.48
457_L577_R0.8760.48
109_R647_D0.8740.47
325_D328_R0.8700.47
652_T878_N0.8680.47
867_I872_E0.8680.47
744_D811_I0.8660.47
259_R368_N0.8640.47
413_Y518_A0.8630.47
304_A316_F0.8630.47
744_D762_T0.8620.47
835_I863_C0.8620.47
89_Q180_C0.8610.46
371_E388_D0.8600.46
270_T273_Q0.8600.46
820_V861_V0.8550.46
150_M543_L0.8530.46
788_L811_I0.8510.46
41_S44_V0.8470.45
452_K491_E0.8470.45
460_K560_L0.8460.45
661_G832_K0.8450.45
92_T98_V0.8440.45
28_A871_T0.8440.45
687_S738_M0.8430.45
826_G861_V0.8420.45
833_I861_V0.8420.45
84_A193_W0.8420.45
838_L847_V0.8410.45
258_L370_V0.8410.45
352_N355_D0.8370.45
590_S593_E0.8360.44
415_M420_Y0.8360.44
94_V505_I0.8340.44
22_Y202_I0.8330.44
680_A777_S0.8320.44
450_L455_V0.8310.44
53_Q60_E0.8300.44
792_V863_C0.8300.44
873_L886_I0.8290.44
97_V170_F0.8280.44
48_N207_T0.8280.44
48_N616_G0.8280.44
459_L574_G0.8270.44
641_R713_H0.8260.44
216_T225_G0.8240.44
721_F785_P0.8230.43
833_I849_V0.8220.43
43_K348_G0.8220.43
207_T314_C0.8210.43
749_S754_A0.8210.43
525_T545_K0.8200.43
70_L73_A0.8180.43
344_A359_F0.8180.43
293_D321_A0.8170.43
794_I849_V0.8170.43
159_F623_I0.8160.43
224_L538_G0.8140.43
667_M827_L0.8140.43
835_I849_V0.8120.43
359_F877_Q0.8110.43
88_M96_A0.8100.42
390_P394_A0.8100.42
817_P864_R0.8100.42
49_L58_V0.8090.42
252_F287_F0.8060.42
567_N571_E0.8060.42
58_V463_P0.8060.42
142_F177_T0.8060.42
389_V527_G0.8050.42
826_G851_L0.8040.42
844_G864_R0.8040.42
150_M619_E0.8040.42
512_P515_I0.8030.42
209_V242_V0.8020.42
450_L487_P0.8010.42
68_G71_K0.8010.42
324_L350_W0.8010.42
56_N874_T0.7990.42
739_T748_V0.7980.42
726_I735_E0.7980.42
304_A540_I0.7980.42
55_G59_T0.7970.41
242_V446_A0.7960.41
73_A248_D0.7960.41
338_E341_E0.7930.41
663_R764_L0.7920.41
158_V626_T0.7910.41
252_F362_T0.7900.41
477_S486_T0.7900.41
397_N424_D0.7900.41
741_H745_S0.7850.41
733_G738_M0.7820.40
193_W204_Y0.7810.40
476_V479_Y0.7810.40
456_T577_R0.7780.40
33_G36_T0.7760.40
727_R732_P0.7760.40
486_T564_M0.7750.40
91_F680_A0.7750.40
703_F720_T0.7750.40
635_E641_R0.7750.40
163_G244_M0.7740.40
826_G859_E0.7720.40
638_T696_R0.7720.40
65_A246_I0.7710.39
684_K722_A0.7700.39
292_L317_F0.7700.39
137_G465_V0.7700.39
335_D338_E0.7670.39
526_V541_H0.7670.39
527_G798_F0.7660.39
328_R337_V0.7660.39
287_F315_G0.7660.39
577_R581_P0.7640.39
92_T777_S0.7630.39
645_F648_E0.7630.39
218_I225_G0.7620.39
117_V169_R0.7620.39
24_S28_A0.7610.39
729_E767_I0.7610.39
514_P518_A0.7600.39
192_V344_A0.7590.39
497_V503_T0.7580.39
205_P349_M0.7560.38
481_A490_D0.7560.38
329_L601_V0.7550.38
427_V462_Q0.7550.38
820_V851_L0.7540.38
138_D141_A0.7540.38
13_L20_Y0.7520.38
499_Y708_S0.7490.38
636_D697_G0.7490.38
671_S774_S0.7490.38
92_T507_N0.7490.38
245_L869_T0.7480.38
157_Y680_A0.7470.38
738_M748_V0.7470.38
828_T859_E0.7460.38
654_A766_V0.7460.38
751_Y754_A0.7450.38
278_H363_L0.7440.37
794_I861_V0.7440.37
516_E541_H0.7430.37
171_S190_K0.7410.37
270_T365_L0.7410.37
254_L271_V0.7400.37
89_Q92_T0.7400.37
538_G550_A0.7400.37
428_V515_I0.7390.37
81_Y207_T0.7390.37
837_D847_V0.7380.37
83_P118_N0.7380.37
132_T705_S0.7370.37
663_R763_P0.7370.37
765_A794_I0.7350.37
855_D858_Q0.7330.37
843_P873_L0.7330.37
97_V446_A0.7310.37
545_K811_I0.7300.36
410_P423_P0.7300.36
252_F271_V0.7290.36
54_D59_T0.7280.36
478_D605_M0.7280.36
218_I304_A0.7280.36
159_F236_A0.7280.36
740_R747_V0.7260.36
180_C707_G0.7260.36
450_L492_L0.7250.36
94_V160_L0.7250.36
576_D581_P0.7240.36
42_L66_L0.7240.36
272_T795_A0.7230.36
302_T443_V0.7230.36
114_T390_P0.7230.36
94_V98_V0.7220.36
87_L142_F0.7220.36
726_I730_M0.7220.36
151_E701_K0.7210.36
192_V319_I0.7200.36
391_K395_A0.7190.36
66_L70_L0.7180.36
426_A493_G0.7160.35
71_K75_A0.7160.35
515_I543_L0.7150.35
189_G304_A0.7140.35
173_V614_F0.7130.35
250_V315_G0.7120.35
598_V601_V0.7120.35
40_K355_D0.7120.35
563_N573_I0.7120.35
482_K600_Q0.7110.35
457_L586_D0.7110.35
416_N420_Y0.7110.35
767_I853_R0.7110.35
812_L867_I0.7100.35
845_A865_C0.7100.35
28_A67_A0.7090.35
102_A642_L0.7080.35
203_A344_A0.7070.35
158_V624_N0.7070.35
40_K352_N0.7070.35
461_R559_A0.7060.35
194_S199_G0.7050.35
224_L292_L0.7050.35
791_R834_D0.7030.34
86_V236_A0.7020.34
752_D755_M0.7020.34
26_P346_A0.7020.34
390_P566_I0.7010.34
316_F357_P0.7010.34
180_C189_G0.7010.34
102_A105_E0.7000.34
661_G852_T0.7000.34
767_I861_V0.6990.34
742_L830_E0.6990.34
730_M851_L0.6980.34
571_E807_I0.6980.34
815_E818_Q0.6970.34
660_H836_G0.6970.34
41_S359_F0.6960.34
216_T304_A0.6960.34
852_T856_G0.6950.34
686_D691_R0.6950.34
160_L505_I0.6950.34
746_D759_Q0.6950.34
411_V415_M0.6940.34
411_V518_A0.6930.34
527_G548_W0.6920.34
664_I851_L0.6920.34
874_T886_I0.6920.34
638_T698_V0.6920.34
324_L328_R0.6920.34
173_V616_G0.6910.34
277_K682_S0.6910.34
302_T440_N0.6900.34
505_I777_S0.6890.34
218_I315_G0.6890.34
257_K652_T0.6880.33
25_L347_Q0.6880.33
606_F706_Y0.6880.33
671_S771_E0.6870.33
44_V785_P0.6870.33
81_Y180_C0.6870.33
796_E819_G0.6860.33
540_I672_V0.6850.33
121_S563_N0.6850.33
792_V811_I0.6840.33
290_D353_P0.6830.33
667_M826_G0.6820.33
422_L428_V0.6820.33
80_A871_T0.6820.33
185_L312_A0.6810.33
40_K351_R0.6810.33
427_V564_M0.6810.33
222_G300_R0.6790.33
253_K362_T0.6790.33
381_Q708_S0.6780.33
132_T468_S0.6780.33
224_L344_A0.6780.33
516_E548_W0.6770.33
48_N82_R0.6770.33
142_F150_M0.6760.33
240_Q886_I0.6760.33
46_L63_I0.6760.33
136_F515_I0.6750.33
445_M455_V0.6730.32
526_V543_L0.6730.32
869_T889_M0.6730.32
13_L346_A0.6720.32
192_V343_Y0.6720.32
758_K791_R0.6710.32
272_T367_M0.6690.32
81_Y87_L0.6690.32
368_N648_E0.6690.32
113_D116_K0.6690.32
469_L486_T0.6680.32
847_V865_C0.6670.32
290_D357_P0.6670.32
107_V114_T0.6670.32
91_F646_F0.6670.32
833_I851_L0.6660.32
379_R671_S0.6660.32
659_I763_P0.6650.32
830_E853_R0.6640.32
270_T370_V0.6630.32
646_F720_T0.6630.32
645_F883_H0.6620.32
452_K605_M0.6620.32
57_S871_T0.6610.32
252_F462_Q0.6610.32
138_D144_E0.6600.31
684_K867_I0.6590.31
260_E590_S0.6590.31
75_A248_D0.6590.31
734_V740_R0.6580.31
798_F834_D0.6560.31
113_D634_Q0.6560.31
707_G720_T0.6560.31
33_G672_V0.6550.31
573_I581_P0.6550.31
288_Y484_K0.6550.31
132_T236_A0.6550.31
553_P594_I0.6540.31
70_L75_A0.6530.31
157_Y170_F0.6530.31
409_Q824_T0.6520.31
163_G869_T0.6510.31
415_M418_H0.6510.31
416_N517_T0.6510.31
359_F798_F0.6510.31
40_K356_E0.6500.31
364_E634_Q0.6500.31
351_R357_P0.6480.31
497_V510_P0.6480.31
767_I798_F0.6470.31
416_N419_Q0.6470.31
224_L246_I0.6460.31
22_Y26_P0.6460.31
742_L748_V0.6460.31
664_I822_R0.6450.30
58_V62_D0.6440.30
57_S81_Y0.6440.30
767_I849_V0.6430.30
634_Q641_R0.6420.30
218_I222_G0.6420.30
444_L631_Y0.6420.30
40_K112_G0.6420.30
236_A244_M0.6420.30
163_G245_L0.6420.30
415_M419_Q0.6410.30
38_L46_L0.6410.30
656_V838_L0.6390.30
43_K347_Q0.6370.30
455_V461_R0.6360.30
263_T475_V0.6350.30
866_R876_Y0.6340.30
540_I634_Q0.6330.30
199_G202_I0.6330.30
254_L295_L0.6330.30
767_I863_C0.6330.30
194_S336_Q0.6320.30
43_K357_P0.6320.30
413_Y420_Y0.6320.30
157_Y164_K0.6310.30
53_Q163_G0.6310.30
27_L207_T0.6310.30
445_M601_V0.6300.29
631_Y640_I0.6300.29
296_P444_L0.6300.29
17_D623_I0.6300.29
297_L301_A0.6290.29
150_M621_K0.6290.29
273_Q373_S0.6290.29
48_N80_A0.6290.29
75_A843_P0.6290.29
148_L701_K0.6290.29
742_L828_T0.6280.29
337_V521_K0.6280.29
207_T878_N0.6270.29
410_P421_Q0.6270.29
541_H548_W0.6260.29
149_E216_T0.6260.29
62_D65_A0.6260.29
300_R320_D0.6250.29
470_A692_Y0.6240.29
116_K120_L0.6240.29
159_F242_V0.6230.29
662_A763_P0.6220.29
689_A693_L0.6220.29
273_Q363_L0.6210.29
450_L574_G0.6210.29
445_M594_I0.6200.29
422_L759_Q0.6190.29
297_L613_V0.6190.29
558_Y564_M0.6190.29
450_L568_L0.6190.29
820_V859_E0.6190.29
282_G687_S0.6190.29
453_K591_A0.6180.29
18_K201_W0.6180.29
571_E576_D0.6180.29
455_V460_K0.6170.29
63_I516_E0.6160.29
44_V578_K0.6160.29
573_I665_L0.6150.29
84_A204_Y0.6150.29
428_V512_P0.6150.29
615_E672_V0.6140.28
423_P426_A0.6140.28
146_V617_T0.6140.28
25_L67_A0.6140.28
296_P322_V0.6130.28
409_Q672_V0.6130.28
141_A626_T0.6130.28
525_T713_H0.6120.28
94_V680_A0.6110.28
515_I520_K0.6110.28
359_F724_I0.6100.28
94_V131_V0.6100.28
42_L246_I0.6090.28
108_K452_K0.6080.28
48_N617_T0.6070.28
605_M751_Y0.6070.28
379_R771_E0.6050.28
444_L597_A0.6050.28
32_L43_K0.6050.28
730_M861_V0.6050.28
180_C190_K0.6040.28
141_A622_G0.6040.28
144_E359_F0.6040.28
550_A724_I0.6040.28
135_R148_L0.6040.28
130_S704_N0.6030.28
268_V303_I0.6030.28
62_D290_D0.6030.28
321_A570_S0.6030.28
161_K624_N0.6020.28
663_R742_L0.6020.28
664_I730_M0.6010.28
875_Y884_Y0.6010.28
56_N871_T0.5990.27
44_V349_M0.5980.27
350_W355_D0.5980.27
383_R424_D0.5980.27
450_L587_I0.5980.27
462_Q465_V0.5980.27
426_A566_I0.5970.27
91_F180_C0.5970.27
146_V157_Y0.5970.27
515_I764_L0.5970.27
631_Y634_Q0.5970.27
124_D316_F0.5960.27
392_A594_I0.5960.27
22_Y27_L0.5960.27
486_T861_V0.5950.27
321_A352_N0.5950.27
307_S314_C0.5950.27
147_R151_E0.5950.27
288_Y367_M0.5950.27
381_Q499_Y0.5950.27
450_L573_I0.5950.27
274_M370_V0.5950.27
836_G848_P0.5940.27
271_V770_K0.5940.27
668_L767_I0.5940.27
42_L374_L0.5930.27
573_I587_I0.5930.27
46_L499_Y0.5930.27
557_A573_I0.5930.27
115_A168_S0.5930.27
177_T614_F0.5930.27
439_S610_Y0.5920.27
645_F649_M0.5920.27
23_Y50_L0.5920.27
727_R731_V0.5920.27
682_S708_S0.5910.27
218_I223_V0.5900.27
163_G424_D0.5900.27
765_A854_A0.5900.27
836_G860_V0.5900.27
161_K837_D0.5900.27
164_K690_G0.5890.27
816_F819_G0.5890.27
698_V835_I0.5880.27
583_Y628_S0.5880.27
243_S884_Y0.5880.27
15_A338_E0.5870.27
218_I842_Q0.5870.27
176_G609_E0.5870.27
315_G444_L0.5860.27
664_I830_E0.5860.27
97_V159_F0.5860.27
486_T849_V0.5850.27
79_I869_T0.5850.27
631_Y755_M0.5850.27
123_V541_H0.5840.27
112_G116_K0.5830.27
118_N127_I0.5830.27
695_G834_D0.5820.26
78_E103_M0.5820.26
59_T62_D0.5820.26
474_K608_K0.5820.26
738_M747_V0.5820.26
323_T713_H0.5820.26
159_F538_G0.5810.26
58_V427_V0.5810.26
510_P515_I0.5810.26
154_H624_N0.5810.26
252_F288_Y0.5800.26
820_V825_L0.5800.26
683_I750_I0.5790.26
252_F278_H0.5790.26
643_S647_D0.5790.26
743_P760_E0.5780.26
89_Q646_F0.5780.26
161_K272_T0.5780.26
147_R346_A0.5780.26
48_N837_D0.5780.26
814_L863_C0.5780.26
167_F172_V0.5770.26
662_A765_A0.5770.26
321_A324_L0.5770.26
262_I387_P0.5760.26
42_L389_V0.5760.26
403_A406_K0.5760.26
189_G886_I0.5760.26
800_R805_N0.5750.26
24_S27_L0.5750.26
729_E811_I0.5750.26
744_D748_V0.5730.26
75_A180_C0.5730.26
189_G225_G0.5730.26
824_T855_D0.5720.26
49_L66_L0.5720.26
48_N53_Q0.5720.26
869_T872_E0.5720.26
816_F821_T0.5710.26
96_A133_V0.5710.26
69_W743_P0.5710.26
244_M268_V0.5710.26
763_P837_D0.5710.26
291_G808_G0.5710.26
62_D523_D0.5700.26
851_L858_Q0.5700.26
96_A208_L0.5700.26
268_V617_T0.5690.26
771_E838_L0.5690.26
146_V177_T0.5690.26
274_M278_H0.5680.26
89_Q132_T0.5670.26
136_F766_V0.5670.26
740_R745_S0.5670.26
341_E350_W0.5660.25
505_I875_Y0.5660.25
132_T634_Q0.5660.25
107_V498_G0.5650.25
530_L547_N0.5640.25
847_V862_P0.5640.25
375_A427_V0.5640.25
109_R645_F0.5640.25
70_L870_A0.5640.25
209_V291_G0.5640.25
208_L218_I0.5640.25
151_E398_E0.5640.25
50_L53_Q0.5630.25
649_M653_P0.5630.25
259_R387_P0.5630.25
477_S496_L0.5630.25
389_V392_A0.5620.25
159_F446_A0.5620.25
244_M616_G0.5620.25
350_W462_Q0.5620.25
344_A349_M0.5620.25
548_W564_M0.5610.25
15_A19_T0.5610.25
103_M505_I0.5610.25
101_A272_T0.5610.25
176_G623_I0.5610.25
329_L337_V0.5610.25
653_P867_I0.5610.25
743_P762_T0.5610.25
762_T798_F0.5600.25
486_T851_L0.5600.25
142_F519_I0.5590.25
407_D424_D0.5590.25
767_I821_T0.5590.25
87_L545_K0.5590.25
730_M853_R0.5590.25
50_L207_T0.5590.25
868_D876_Y0.5590.25
560_L576_D0.5580.25
431_A541_H0.5580.25
121_S871_T0.5580.25
569_A762_T0.5580.25
601_V605_M0.5580.25
26_P29_A0.5570.25
61_E257_K0.5550.25
84_A341_E0.5550.25
163_G166_A0.5540.25
265_T438_T0.5540.25
157_Y381_Q0.5540.25
396_S890_L0.5540.25
798_F843_P0.5540.25
106_A726_I0.5530.25
616_G623_I0.5530.25
817_P863_C0.5530.25
457_L581_P0.5530.25
822_R861_V0.5530.25
741_H746_D0.5530.25
298_A538_G0.5520.25
347_Q383_R0.5520.25
78_E809_M0.5520.25
448_G480_L0.5510.25
290_D548_W0.5510.25
234_E681_G0.5510.25
812_L838_L0.5500.25
98_V711_G0.5500.25
396_S568_L0.5500.25
665_L668_L0.5500.25
252_F273_Q0.5480.24
524_L725_R0.5480.24
394_A452_K0.5480.24
716_M719_G0.5470.24
124_D176_G0.5470.24
43_K550_A0.5470.24
497_V508_S0.5470.24
666_A737_G0.5460.24
732_P740_R0.5460.24
41_S314_C0.5460.24
120_L659_I0.5460.24
730_M830_E0.5460.24
319_I372_A0.5460.24
371_E653_P0.5450.24
208_L645_F0.5450.24
157_Y774_S0.5440.24
431_A683_I0.5440.24
692_Y751_Y0.5430.24
648_E887_R0.5430.24
680_A719_G0.5430.24
505_I708_S0.5420.24
690_G764_L0.5420.24
69_W633_W0.5420.24
218_I330_S0.5420.24
120_L885_V0.5420.24
136_F304_A0.5410.24
768_A791_R0.5410.24
613_V717_M0.5410.24
25_L28_A0.5410.24
98_V645_F0.5410.24
496_L568_L0.5400.24
346_A349_M0.5400.24
304_A314_C0.5400.24
549_L719_G0.5400.24
110_L878_N0.5400.24
290_D602_S0.5400.24
651_A890_L0.5390.24
161_K165_Q0.5390.24
537_E707_G0.5390.24
134_D737_G0.5380.24
278_H288_Y0.5380.24
172_V323_T0.5380.24
250_V656_V0.5380.24
796_E822_R0.5380.24
682_S766_V0.5380.24
243_S871_T0.5380.24
124_D843_P0.5380.24
116_K889_M0.5370.24
53_Q645_F0.5370.24
329_L336_Q0.5370.24
766_V774_S0.5370.24
265_T437_N0.5360.24
218_I598_V0.5360.24
255_T370_V0.5360.24
660_H791_R0.5360.24
180_C193_W0.5360.24
284_F314_C0.5350.24
827_L854_A0.5350.24
573_I873_L0.5350.24
207_T502_T0.5350.24
834_D860_V0.5350.24
103_M889_M0.5340.24
475_V610_Y0.5340.24
42_L464_W0.5330.24
609_E613_V0.5330.24
507_N680_A0.5330.24
636_D828_T0.5330.24
110_L650_Q0.5330.24
263_T553_P0.5320.23
216_T314_C0.5320.23
558_Y865_C0.5320.23
185_L297_L0.5320.23
103_M680_A0.5320.23
444_L480_L0.5310.23
870_A874_T0.5310.23
750_I766_V0.5310.23
262_I495_N0.5310.23
92_T707_G0.5310.23
44_V295_L0.5310.23
281_V313_T0.5310.23
15_A203_A0.5310.23
848_P859_E0.5300.23
407_D410_P0.5300.23
312_A643_S0.5300.23
146_V726_I0.5300.23
157_Y177_T0.5300.23
445_M528_A0.5290.23
765_A817_P0.5290.23
827_L833_I0.5290.23
96_A236_A0.5290.23
491_E890_L0.5290.23
428_V519_I0.5290.23
727_R838_L0.5280.23
375_A383_R0.5280.23
278_H672_V0.5270.23
843_P870_A0.5270.23
126_V173_V0.5270.23
349_M598_V0.5270.23
565_N851_L0.5270.23
288_Y297_L0.5270.23
224_L298_A0.5270.23
378_K731_V0.5260.23
503_T508_S0.5260.23
671_S732_P0.5260.23
108_K114_T0.5260.23
381_Q771_E0.5250.23
165_Q729_E0.5250.23
132_T161_K0.5240.23
43_K538_G0.5240.23
79_I752_D0.5230.23
339_L359_F0.5230.23
74_H360_T0.5230.23
110_L653_P0.5230.23
163_G303_I0.5220.23
252_F315_G0.5220.23
671_S705_S0.5220.23
513_D608_K0.5210.23
566_I706_Y0.5210.23
804_S808_G0.5210.23
80_A121_S0.5210.23
21_H890_L0.5200.23
115_A708_S0.5200.23
304_A774_S0.5190.23
18_K349_M0.5190.23
279_G712_N0.5180.23
130_S505_I0.5180.23
527_G541_H0.5180.23
176_G542_P0.5180.23
368_N748_V0.5180.23
86_V160_L0.5180.23
390_P570_S0.5180.23
132_T774_S0.5180.23
139_D490_D0.5170.23
209_V442_S0.5170.23
270_T527_G0.5170.23
335_D655_P0.5170.23
523_D526_V0.5170.23
140_E143_E0.5160.23
766_V818_Q0.5160.23
362_T483_A0.5160.23
254_L287_F0.5150.23
482_K640_I0.5150.23
684_K738_M0.5150.23
683_I749_S0.5150.23
110_L649_M0.5150.23
274_M369_D0.5150.23
721_F766_V0.5140.22
429_I503_T0.5140.22
756_R791_R0.5140.22
240_Q871_T0.5140.22
484_K488_Y0.5140.22
559_A705_S0.5140.22
716_M780_W0.5130.22
224_L613_V0.5130.22
274_M587_I0.5130.22
48_N631_Y0.5130.22
252_F601_V0.5120.22
587_I631_Y0.5120.22
117_V626_T0.5120.22
491_E577_R0.5120.22
28_A34_D0.5120.22
79_I684_K0.5110.22
375_A870_A0.5110.22
259_R369_D0.5110.22
56_N236_A0.5110.22
717_M726_I0.5110.22
87_L224_L0.5100.22
626_T697_G0.5100.22
379_R547_N0.5100.22
243_S298_A0.5100.22
134_D429_I0.5100.22
91_F505_I0.5100.22
20_Y177_T0.5100.22
324_L364_E0.5100.22
50_L737_G0.5090.22
666_A823_K0.5090.22
683_I748_V0.5080.22
76_D844_G0.5080.22
341_E344_A0.5080.22
105_E641_R0.5080.22
849_V862_P0.5080.22
116_K168_S0.5080.22
452_K582_V0.5080.22
722_A737_G0.5070.22
108_K113_D0.5070.22
507_N707_G0.5070.22
89_Q126_V0.5070.22
110_L890_L0.5070.22
221_L873_L0.5070.22
316_F865_C0.5070.22
139_D657_E0.5060.22
236_A871_T0.5060.22
272_T349_M0.5050.22
35_I43_K0.5050.22
540_I649_M0.5050.22
574_G587_I0.5050.22
609_E612_E0.5050.22
429_I470_A0.5050.22
698_V703_F0.5040.22
431_A890_L0.5040.22
13_L22_Y0.5040.22
127_I583_Y0.5040.22
68_G113_D0.5030.22
268_V462_Q0.5030.22
394_A580_D0.5030.22
363_L654_A0.5030.22
572_P575_H0.5020.22
518_A567_N0.5020.22
41_S79_I0.5010.22
791_R877_Q0.5010.22
497_V528_A0.5000.22
816_F822_R0.5000.22
103_M393_F0.5000.22
121_S209_V0.5000.22
599_E604_E0.5000.22
182_Q238_L0.5000.22
180_C272_T0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2b3yA 1 0.9843 100 0.284 Contact Map
1c96A 1 0.8305 100 0.505 Contact Map
4kp2A 2 0.4669 100 0.707 Contact Map
4kp1A 1 0.4669 100 0.715 Contact Map
1l5jA 1 0.5679 100 0.733 Contact Map
3vbaA 2 0.1863 100 0.913 Contact Map
2pkpA 2 0.1818 100 0.913 Contact Map
1v7lA 6 0.1796 100 0.915 Contact Map
2hcuA 1 0.1942 100 0.918 Contact Map
3q3wA 1 0.1987 100 0.923 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0198 seconds.