ACON1 - ECOLI - GREMLIN Contacts

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ACON1 - Aconitate hydratase 1

UniProt:	P25516	Sequences: MSSTLREASKDTLQAKDKTYHYYSLPLAAKSLGDITRLPKSLKVLLENLLRWQDGNSVTEEDIHALAGWLKNAHADREIAYRPARVLMQDFTGVPAVVDLAAMREAVKRLGGDTAKVNPLSPVDLVIDHSVTVDRFGDDEAFEENVRLEMERNHERYVFLKWGKQAFSRFSVVPPGTGICHQVNLEYLGKAVWSELQDGEWIAYPDTLVGTDSHTTMINGLGVLGWGVGGIEAEAAMLGQPVSMLIPDVVGFKLTGKLREGITATDLVLTVTQMLRKHGVVGKFVEFYGDGLDSLPLADRATIANMSPEYGATCGFFPIDAVTLDYMRLSGRSEDQVELVEKYAKAQGMWRNPGDEPIFTSTLELDMNDVEASLAGPKRPQDRVALPDVPKAFAASNELEVNATHKDRQPVDYVMNGHQYQLPDGAVVIAAITSCTNTSNPSVLMAAGLLAKKAVTLGLKRQPWVKASLAPGSKVVSDYLAKAKLTPYLDELGFNLVGYGCTTCIGNSGPLPDPIETAIKKSDLTVGAVLSGNRNFEGRIHPLVKTNWLASPPLVVAYALAGNMNINLASEPIGHDRKGDPVYLKDIWPSAQEIARAVEQVSTEMFRKEYAEVFEGTAEWKGINVTRSDTYGWQEDSTYIRLSPFFDEMQATPAPVEDIHGARILAMLGDSVTTDHISPAGSIKPDSPAGRYLQGRGVERKDFNSYGSRRGNHEVMMRGTFANIRIRNEMVPGVEGGMTRHLPDSDVVSIYDAAMRYKQEQTPLAVIAGKEYGSGSSRDWAAKGPRLLGIRVVIAESFERIHRSNLIGMGILPLEFPQGVTRKTLGLTGEEKIDIGDLQNLQPGATVPVTLTRADGSQEVVPCRCRIDTATELTYYQNDGILHYVIRNMLK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11325
Length:	891 (871)
Sequences:	2126 (875)
Seq/√Len:	29.6

ECOLI - ACON1 YBHJ
BACSU - ACON
HALSA - Q9HMF1
SULSO - Q97Z42

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
575_H	581_P	5.531	1.00
666_A	750_I	5.123	1.00
288_Y	362_T	5.058	1.00
452_K	488_Y	4.730	1.00
278_H	361_S	4.724	1.00
319_I	344_A	4.717	1.00
486_T	490_D	4.587	1.00
741_H	760_E	4.461	1.00
477_S	499_Y	4.409	1.00
785_P	811_I	4.377	1.00
741_H	744_D	4.327	1.00
328_R	334_E	4.132	1.00
322_V	325_D	4.041	1.00
258_L	267_L	4.007	1.00
253_K	364_E	3.964	1.00
341_E	345_K	3.930	1.00
452_K	456_T	3.827	1.00
770_K	796_E	3.732	1.00
490_D	495_N	3.711	1.00
576_D	580_D	3.626	1.00
517_T	521_K	3.545	1.00
453_K	593_E	3.468	1.00
731_V	734_V	3.423	1.00
455_V	488_Y	3.393	1.00
470_A	502_T	3.331	1.00
259_R	262_I	3.313	1.00
849_V	863_C	3.299	1.00
224_L	314_C	3.296	1.00
853_R	859_E	3.245	1.00
87_L	180_C	3.053	1.00
713_H	717_M	3.041	1.00
136_F	512_P	2.952	1.00
456_T	488_Y	2.949	1.00
847_V	863_C	2.936	1.00
274_M	363_L	2.919	1.00
457_L	576_D	2.919	1.00
453_K	456_T	2.886	1.00
661_G	834_D	2.883	1.00
250_V	361_S	2.810	1.00
817_P	846_T	2.806	1.00
203_A	339_L	2.792	1.00
664_I	833_I	2.782	1.00
768_A	795_A	2.656	1.00
124_D	171_S	2.652	1.00
60_E	64_H	2.647	1.00
488_Y	491_E	2.640	1.00
374_L	389_V	2.632	1.00
851_L	861_V	2.626	1.00
741_H	756_R	2.620	1.00
148_L	151_E	2.595	1.00
849_V	861_V	2.592	1.00
516_E	543_L	2.583	1.00
109_R	642_L	2.571	0.99
834_D	852_T	2.567	0.99
29_A	34_D	2.543	0.99
771_E	774_S	2.523	0.99
527_G	564_M	2.497	0.99
250_V	360_T	2.493	0.99
739_T	753_A	2.473	0.99
729_E	822_R	2.470	0.99
29_A	36_T	2.462	0.99
11_D	27_L	2.447	0.99
746_D	756_R	2.400	0.99
371_E	387_P	2.395	0.99
563_N	566_I	2.365	0.99
389_V	564_M	2.311	0.99
250_V	278_H	2.306	0.99
274_M	365_L	2.303	0.99
105_E	642_L	2.296	0.99
293_D	351_R	2.263	0.99
734_V	747_V	2.251	0.99
158_V	634_Q	2.251	0.99
385_A	388_D	2.238	0.99
135_R	144_E	2.236	0.99
796_E	821_T	2.218	0.98
817_P	820_V	2.212	0.98
567_N	570_S	2.207	0.98
133_V	468_S	2.205	0.98
751_Y	755_M	2.201	0.98
455_V	491_E	2.199	0.98
612_E	615_E	2.199	0.98
37_R	358_I	2.194	0.98
392_A	548_W	2.155	0.98
273_Q	277_K	2.153	0.98
431_A	502_T	2.144	0.98
146_V	176_G	2.142	0.98
846_T	862_P	2.142	0.98
660_H	834_D	2.133	0.98
470_A	497_V	2.093	0.98
658_D	837_D	2.085	0.98
189_G	223_V	2.068	0.98
683_I	687_S	2.065	0.97
668_L	726_I	2.063	0.97
177_T	613_V	2.048	0.97
792_V	835_I	2.032	0.97
310_Y	315_G	2.030	0.97
446_A	553_P	2.024	0.97
729_E	823_K	2.013	0.97
142_F	496_L	1.998	0.97
446_A	594_I	1.987	0.97
450_L	453_K	1.978	0.97
189_G	218_I	1.976	0.97
273_Q	383_R	1.974	0.97
520_K	543_L	1.973	0.97
641_R	714_E	1.970	0.97
371_E	385_A	1.969	0.97
595_A	598_V	1.966	0.97
592_Q	596_R	1.960	0.97
374_L	550_A	1.959	0.97
388_D	391_K	1.953	0.96
307_S	310_Y	1.949	0.96
748_V	753_A	1.944	0.96
765_A	833_I	1.935	0.96
699_E	702_D	1.930	0.96
194_S	201_W	1.919	0.96
150_M	617_T	1.910	0.96
366_D	369_D	1.908	0.96
144_E	147_R	1.899	0.96
836_G	850_T	1.898	0.96
22_Y	346_A	1.896	0.96
667_M	729_E	1.889	0.96
390_P	571_E	1.884	0.96
481_A	486_T	1.874	0.96
252_F	274_M	1.873	0.95
307_S	315_G	1.871	0.95
744_D	756_R	1.870	0.95
732_P	738_M	1.868	0.95
11_D	24_S	1.864	0.95
165_Q	627_R	1.864	0.95
61_E	64_H	1.855	0.95
748_V	756_R	1.848	0.95
851_L	859_E	1.846	0.95
253_K	356_E	1.839	0.95
848_P	860_V	1.826	0.95
706_Y	722_A	1.825	0.95
69_W	360_T	1.821	0.95
192_V	203_A	1.819	0.95
444_L	469_L	1.817	0.95
497_V	502_T	1.817	0.95
878_N	887_R	1.817	0.95
453_K	457_L	1.808	0.95
821_T	824_T	1.807	0.95
664_I	667_M	1.805	0.94
767_I	833_I	1.802	0.94
297_L	322_V	1.798	0.94
389_V	558_Y	1.796	0.94
15_A	18_K	1.783	0.94
270_T	373_S	1.773	0.94
705_S	708_S	1.763	0.94
659_I	662_A	1.759	0.94
850_T	860_V	1.756	0.94
445_M	597_A	1.750	0.93
642_L	647_D	1.748	0.93
667_M	822_R	1.737	0.93
140_E	144_E	1.737	0.93
16_K	335_D	1.716	0.93
618_A	622_G	1.705	0.93
720_T	784_G	1.705	0.93
684_K	690_G	1.697	0.92
23_Y	202_I	1.684	0.92
15_A	20_Y	1.668	0.92
450_L	457_L	1.653	0.91
848_P	862_P	1.647	0.91
834_D	850_T	1.647	0.91
161_K	625_V	1.645	0.91
373_S	383_R	1.642	0.91
142_F	146_V	1.642	0.91
744_D	760_E	1.641	0.91
450_L	557_A	1.641	0.91
321_A	325_D	1.640	0.91
478_D	609_E	1.634	0.91
312_A	315_G	1.630	0.91
830_E	854_A	1.627	0.91
852_T	858_Q	1.623	0.91
663_R	762_T	1.622	0.91
453_K	590_S	1.619	0.90
727_R	735_E	1.618	0.90
748_V	752_D	1.615	0.90
133_V	431_A	1.599	0.90
505_I	680_A	1.593	0.90
731_V	740_R	1.590	0.90
714_E	717_M	1.588	0.90
14_Q	17_D	1.583	0.89
379_R	382_D	1.580	0.89
756_R	760_E	1.574	0.89
756_R	759_Q	1.563	0.89
487_P	490_D	1.562	0.89
107_V	112_G	1.559	0.89
767_I	822_R	1.559	0.89
381_Q	671_S	1.551	0.88
53_Q	63_I	1.543	0.88
248_D	361_S	1.534	0.88
867_I	876_Y	1.533	0.88
691_R	695_G	1.532	0.88
394_A	565_N	1.529	0.88
118_N	169_R	1.529	0.88
457_L	582_V	1.524	0.88
365_L	369_D	1.520	0.87
717_M	755_M	1.519	0.87
767_I	851_L	1.518	0.87
617_T	621_K	1.513	0.87
321_A	341_E	1.513	0.87
615_E	621_K	1.513	0.87
731_V	747_V	1.504	0.87
64_H	68_G	1.503	0.87
828_T	853_R	1.502	0.87
430_A	494_F	1.493	0.86
687_S	706_Y	1.487	0.86
575_H	579_G	1.484	0.86
89_Q	707_G	1.477	0.86
623_I	626_T	1.475	0.86
519_I	541_H	1.468	0.85
365_L	370_V	1.467	0.85
253_K	288_Y	1.464	0.85
812_L	876_Y	1.463	0.85
194_S	203_A	1.463	0.85
457_L	580_D	1.461	0.85
390_P	567_N	1.458	0.85
260_E	591_A	1.456	0.85
316_F	319_I	1.456	0.85
11_D	22_Y	1.454	0.85
815_E	864_R	1.452	0.85
853_R	857_S	1.451	0.85
124_D	190_K	1.443	0.84
334_E	338_E	1.427	0.84
741_H	748_V	1.419	0.83
16_K	338_E	1.418	0.83
478_D	608_K	1.414	0.83
740_R	830_E	1.407	0.83
159_F	163_G	1.404	0.83
767_I	816_F	1.401	0.83
450_L	590_S	1.394	0.82
190_K	193_W	1.387	0.82
292_L	351_R	1.379	0.82
519_I	526_V	1.372	0.81
523_D	545_K	1.370	0.81
668_L	750_I	1.365	0.81
494_F	559_A	1.362	0.81
832_K	852_T	1.361	0.81
667_M	823_K	1.352	0.80
49_L	63_I	1.349	0.80
483_A	597_A	1.348	0.80
596_R	600_Q	1.348	0.80
190_K	336_Q	1.348	0.80
482_K	602_S	1.348	0.80
658_D	836_G	1.345	0.80
426_A	565_N	1.340	0.80
738_M	749_S	1.332	0.79
478_D	481_A	1.330	0.79
483_A	486_T	1.330	0.79
344_A	350_W	1.326	0.79
525_T	546_T	1.323	0.79
117_V	889_M	1.322	0.79
429_I	544_V	1.322	0.79
445_M	598_V	1.320	0.79
115_A	629_D	1.319	0.79
601_V	606_F	1.311	0.78
455_V	487_P	1.311	0.78
143_E	147_R	1.310	0.78
452_K	455_V	1.300	0.78
253_K	290_D	1.296	0.77
754_A	758_K	1.294	0.77
22_Y	203_A	1.292	0.77
382_D	671_S	1.291	0.77
874_T	877_Q	1.291	0.77
109_R	648_E	1.285	0.77
665_L	790_I	1.280	0.77
428_V	544_V	1.277	0.76
653_P	878_N	1.273	0.76
667_M	767_I	1.272	0.76
734_V	738_M	1.270	0.76
766_V	790_I	1.270	0.76
741_H	762_T	1.268	0.76
324_L	337_V	1.267	0.76
146_V	150_M	1.267	0.76
878_N	884_Y	1.261	0.75
518_A	522_S	1.261	0.75
817_P	862_P	1.261	0.75
191_A	327_M	1.260	0.75
307_S	312_A	1.259	0.75
14_Q	19_T	1.259	0.75
133_V	497_V	1.248	0.75
134_D	152_R	1.240	0.74
298_A	329_L	1.237	0.74
486_T	496_L	1.234	0.74
396_S	548_W	1.233	0.74
846_T	864_R	1.232	0.74
21_H	200_E	1.228	0.73
393_F	548_W	1.224	0.73
74_H	248_D	1.221	0.73
658_D	838_L	1.220	0.73
304_A	315_G	1.218	0.73
135_R	141_A	1.214	0.73
730_M	742_L	1.211	0.72
727_R	733_G	1.199	0.72
820_V	824_T	1.198	0.72
381_Q	774_S	1.190	0.71
444_L	528_A	1.187	0.71
694_Q	700_R	1.187	0.71
338_E	342_K	1.183	0.71
154_H	158_V	1.181	0.70
461_R	467_A	1.180	0.70
663_R	832_K	1.177	0.70
828_T	854_A	1.172	0.70
24_S	347_Q	1.166	0.69
826_G	853_R	1.166	0.69
774_S	785_P	1.161	0.69
15_A	342_K	1.161	0.69
867_I	873_L	1.155	0.69
604_E	608_K	1.154	0.69
89_Q	720_T	1.151	0.68
406_K	409_Q	1.150	0.68
513_D	517_T	1.149	0.68
487_P	491_E	1.148	0.68
558_Y	563_N	1.147	0.68
333_S	336_Q	1.147	0.68
685_P	690_G	1.141	0.68
412_D	421_Q	1.140	0.68
29_A	32_L	1.138	0.68
342_K	346_A	1.136	0.67
516_E	520_K	1.136	0.67
310_Y	316_F	1.136	0.67
815_E	866_R	1.130	0.67
420_Y	515_I	1.126	0.67
135_R	138_D	1.125	0.67
739_T	750_I	1.124	0.67
105_E	630_T	1.124	0.67
563_N	571_E	1.124	0.67
260_E	592_Q	1.123	0.66
430_A	559_A	1.122	0.66
667_M	730_M	1.121	0.66
729_E	821_T	1.120	0.66
743_P	748_V	1.119	0.66
691_R	749_S	1.118	0.66
755_M	758_K	1.117	0.66
692_Y	714_E	1.111	0.66
474_K	609_E	1.111	0.66
575_H	580_D	1.109	0.65
566_I	572_P	1.109	0.65
143_E	619_E	1.109	0.65
566_I	571_E	1.109	0.65
684_K	687_S	1.107	0.65
91_F	94_V	1.100	0.65
560_L	587_I	1.099	0.65
259_R	371_E	1.098	0.65
392_A	396_S	1.097	0.65
257_K	294_S	1.095	0.64
384_V	396_S	1.094	0.64
453_K	587_I	1.094	0.64
18_K	335_D	1.090	0.64
80_A	243_S	1.086	0.64
248_D	360_T	1.083	0.64
57_S	82_R	1.075	0.63
92_T	505_I	1.067	0.62
91_F	720_T	1.065	0.62
427_V	529_V	1.064	0.62
749_S	752_D	1.061	0.62
114_T	815_E	1.060	0.62
785_P	788_L	1.056	0.62
461_R	492_L	1.053	0.61
216_T	315_G	1.053	0.61
62_D	77_R	1.050	0.61
456_T	487_P	1.049	0.61
743_P	756_R	1.047	0.61
221_L	297_L	1.046	0.61
668_L	672_V	1.044	0.61
642_L	645_F	1.040	0.60
100_L	167_F	1.037	0.60
374_L	384_V	1.037	0.60
304_A	312_A	1.036	0.60
732_P	747_V	1.035	0.60
429_I	508_S	1.034	0.60
244_M	869_T	1.032	0.60
220_G	304_A	1.030	0.60
91_F	707_G	1.030	0.60
107_V	889_M	1.029	0.60
255_T	364_E	1.029	0.60
685_P	694_Q	1.026	0.59
88_M	180_C	1.025	0.59
185_L	301_A	1.024	0.59
40_K	359_F	1.021	0.59
268_V	616_G	1.020	0.59
194_S	339_L	1.020	0.59
40_K	354_G	1.018	0.59
452_K	487_P	1.018	0.59
171_S	614_F	1.018	0.59
54_D	58_V	1.017	0.59
411_V	522_S	1.016	0.59
328_R	341_E	1.014	0.58
576_D	582_V	1.013	0.58
794_I	863_C	1.013	0.58
850_T	858_Q	1.013	0.58
135_R	140_E	1.011	0.58
24_S	346_A	1.009	0.58
412_D	419_Q	1.008	0.58
20_Y	203_A	1.008	0.58
455_V	492_L	1.008	0.58
12_T	19_T	1.007	0.58
603_T	607_R	1.002	0.58
664_I	767_I	1.002	0.58
658_D	839_Q	1.001	0.57
66_L	246_I	1.001	0.57
304_A	307_S	1.001	0.57
490_D	496_L	0.999	0.57
683_I	738_M	0.999	0.57
287_F	594_I	0.999	0.57
731_V	738_M	0.996	0.57
25_L	35_I	0.992	0.57
13_L	342_K	0.992	0.57
786_R	791_R	0.989	0.57
650_Q	654_A	0.988	0.56
21_H	202_I	0.987	0.56
185_L	218_I	0.987	0.56
569_A	585_K	0.987	0.56
557_A	584_L	0.986	0.56
389_V	548_W	0.986	0.56
48_N	464_W	0.985	0.56
428_V	526_V	0.985	0.56
381_Q	705_S	0.984	0.56
252_F	365_L	0.984	0.56
133_V	502_T	0.984	0.56
390_P	565_N	0.982	0.56
820_V	862_P	0.982	0.56
628_S	632_G	0.982	0.56
374_L	564_M	0.981	0.56
327_M	340_V	0.977	0.56
692_Y	713_H	0.976	0.55
278_H	362_T	0.975	0.55
147_R	619_E	0.961	0.54
105_E	109_R	0.959	0.54
765_A	785_P	0.957	0.54
336_Q	339_L	0.956	0.54
107_V	116_K	0.951	0.54
686_D	690_G	0.949	0.53
250_V	304_A	0.949	0.53
691_R	694_Q	0.948	0.53
52_W	82_R	0.948	0.53
815_E	868_D	0.946	0.53
92_T	680_A	0.944	0.53
767_I	794_I	0.941	0.53
110_L	887_R	0.938	0.53
44_V	221_L	0.938	0.53
450_L	572_P	0.935	0.52
133_V	498_G	0.934	0.52
819_G	824_T	0.934	0.52
144_E	148_L	0.934	0.52
150_M	548_W	0.934	0.52
45_L	83_P	0.932	0.52
271_V	365_L	0.929	0.52
486_T	495_N	0.928	0.52
482_K	605_M	0.924	0.51
86_V	209_V	0.924	0.51
618_A	621_K	0.919	0.51
319_I	350_W	0.917	0.51
450_L	584_L	0.917	0.51
649_M	887_R	0.916	0.51
796_E	823_K	0.916	0.51
393_F	546_T	0.914	0.51
295_L	299_D	0.913	0.51
307_S	774_S	0.913	0.51
283_K	361_S	0.913	0.51
561_A	566_I	0.912	0.50
666_A	726_I	0.911	0.50
685_P	700_R	0.910	0.50
102_A	643_S	0.907	0.50
49_L	53_Q	0.905	0.50
659_I	835_I	0.904	0.50
560_L	573_I	0.903	0.50
653_P	887_R	0.900	0.50
384_V	548_W	0.899	0.49
414_V	419_Q	0.899	0.49
626_T	632_G	0.899	0.49
107_V	117_V	0.898	0.49
765_A	792_V	0.897	0.49
842_Q	845_A	0.895	0.49
252_F	370_V	0.894	0.49
563_N	568_L	0.892	0.49
641_R	712_N	0.892	0.49
616_G	621_K	0.890	0.49
134_D	148_L	0.889	0.49
851_L	863_C	0.888	0.49
726_I	749_S	0.887	0.48
448_G	469_L	0.884	0.48
163_G	268_V	0.882	0.48
577_R	580_D	0.881	0.48
350_W	464_W	0.881	0.48
461_R	464_W	0.880	0.48
595_A	599_E	0.880	0.48
491_E	495_N	0.880	0.48
460_K	491_E	0.879	0.48
457_L	577_R	0.876	0.48
109_R	647_D	0.874	0.47
325_D	328_R	0.870	0.47
652_T	878_N	0.868	0.47
867_I	872_E	0.868	0.47
744_D	811_I	0.866	0.47
259_R	368_N	0.864	0.47
413_Y	518_A	0.863	0.47
304_A	316_F	0.863	0.47
744_D	762_T	0.862	0.47
835_I	863_C	0.862	0.47
89_Q	180_C	0.861	0.46
371_E	388_D	0.860	0.46
270_T	273_Q	0.860	0.46
820_V	861_V	0.855	0.46
150_M	543_L	0.853	0.46
788_L	811_I	0.851	0.46
41_S	44_V	0.847	0.45
452_K	491_E	0.847	0.45
460_K	560_L	0.846	0.45
661_G	832_K	0.845	0.45
92_T	98_V	0.844	0.45
28_A	871_T	0.844	0.45
687_S	738_M	0.843	0.45
826_G	861_V	0.842	0.45
833_I	861_V	0.842	0.45
84_A	193_W	0.842	0.45
838_L	847_V	0.841	0.45
258_L	370_V	0.841	0.45
352_N	355_D	0.837	0.45
590_S	593_E	0.836	0.44
415_M	420_Y	0.836	0.44
94_V	505_I	0.834	0.44
22_Y	202_I	0.833	0.44
680_A	777_S	0.832	0.44
450_L	455_V	0.831	0.44
53_Q	60_E	0.830	0.44
792_V	863_C	0.830	0.44
873_L	886_I	0.829	0.44
97_V	170_F	0.828	0.44
48_N	207_T	0.828	0.44
48_N	616_G	0.828	0.44
459_L	574_G	0.827	0.44
641_R	713_H	0.826	0.44
216_T	225_G	0.824	0.44
721_F	785_P	0.823	0.43
833_I	849_V	0.822	0.43
43_K	348_G	0.822	0.43
207_T	314_C	0.821	0.43
749_S	754_A	0.821	0.43
525_T	545_K	0.820	0.43
70_L	73_A	0.818	0.43
344_A	359_F	0.818	0.43
293_D	321_A	0.817	0.43
794_I	849_V	0.817	0.43
159_F	623_I	0.816	0.43
224_L	538_G	0.814	0.43
667_M	827_L	0.814	0.43
835_I	849_V	0.812	0.43
359_F	877_Q	0.811	0.43
88_M	96_A	0.810	0.42
390_P	394_A	0.810	0.42
817_P	864_R	0.810	0.42
49_L	58_V	0.809	0.42
252_F	287_F	0.806	0.42
567_N	571_E	0.806	0.42
58_V	463_P	0.806	0.42
142_F	177_T	0.806	0.42
389_V	527_G	0.805	0.42
826_G	851_L	0.804	0.42
844_G	864_R	0.804	0.42
150_M	619_E	0.804	0.42
512_P	515_I	0.803	0.42
209_V	242_V	0.802	0.42
450_L	487_P	0.801	0.42
68_G	71_K	0.801	0.42
324_L	350_W	0.801	0.42
56_N	874_T	0.799	0.42
739_T	748_V	0.798	0.42
726_I	735_E	0.798	0.42
304_A	540_I	0.798	0.42
55_G	59_T	0.797	0.41
242_V	446_A	0.796	0.41
73_A	248_D	0.796	0.41
338_E	341_E	0.793	0.41
663_R	764_L	0.792	0.41
158_V	626_T	0.791	0.41
252_F	362_T	0.790	0.41
477_S	486_T	0.790	0.41
397_N	424_D	0.790	0.41
741_H	745_S	0.785	0.41
733_G	738_M	0.782	0.40
193_W	204_Y	0.781	0.40
476_V	479_Y	0.781	0.40
456_T	577_R	0.778	0.40
33_G	36_T	0.776	0.40
727_R	732_P	0.776	0.40
486_T	564_M	0.775	0.40
91_F	680_A	0.775	0.40
703_F	720_T	0.775	0.40
635_E	641_R	0.775	0.40
163_G	244_M	0.774	0.40
826_G	859_E	0.772	0.40
638_T	696_R	0.772	0.40
65_A	246_I	0.771	0.39
684_K	722_A	0.770	0.39
292_L	317_F	0.770	0.39
137_G	465_V	0.770	0.39
335_D	338_E	0.767	0.39
526_V	541_H	0.767	0.39
527_G	798_F	0.766	0.39
328_R	337_V	0.766	0.39
287_F	315_G	0.766	0.39
577_R	581_P	0.764	0.39
92_T	777_S	0.763	0.39
645_F	648_E	0.763	0.39
218_I	225_G	0.762	0.39
117_V	169_R	0.762	0.39
24_S	28_A	0.761	0.39
729_E	767_I	0.761	0.39
514_P	518_A	0.760	0.39
192_V	344_A	0.759	0.39
497_V	503_T	0.758	0.39
205_P	349_M	0.756	0.38
481_A	490_D	0.756	0.38
329_L	601_V	0.755	0.38
427_V	462_Q	0.755	0.38
820_V	851_L	0.754	0.38
138_D	141_A	0.754	0.38
13_L	20_Y	0.752	0.38
499_Y	708_S	0.749	0.38
636_D	697_G	0.749	0.38
671_S	774_S	0.749	0.38
92_T	507_N	0.749	0.38
245_L	869_T	0.748	0.38
157_Y	680_A	0.747	0.38
738_M	748_V	0.747	0.38
828_T	859_E	0.746	0.38
654_A	766_V	0.746	0.38
751_Y	754_A	0.745	0.38
278_H	363_L	0.744	0.37
794_I	861_V	0.744	0.37
516_E	541_H	0.743	0.37
171_S	190_K	0.741	0.37
270_T	365_L	0.741	0.37
254_L	271_V	0.740	0.37
89_Q	92_T	0.740	0.37
538_G	550_A	0.740	0.37
428_V	515_I	0.739	0.37
81_Y	207_T	0.739	0.37
837_D	847_V	0.738	0.37
83_P	118_N	0.738	0.37
132_T	705_S	0.737	0.37
663_R	763_P	0.737	0.37
765_A	794_I	0.735	0.37
855_D	858_Q	0.733	0.37
843_P	873_L	0.733	0.37
97_V	446_A	0.731	0.37
545_K	811_I	0.730	0.36
410_P	423_P	0.730	0.36
252_F	271_V	0.729	0.36
54_D	59_T	0.728	0.36
478_D	605_M	0.728	0.36
218_I	304_A	0.728	0.36
159_F	236_A	0.728	0.36
740_R	747_V	0.726	0.36
180_C	707_G	0.726	0.36
450_L	492_L	0.725	0.36
94_V	160_L	0.725	0.36
576_D	581_P	0.724	0.36
42_L	66_L	0.724	0.36
272_T	795_A	0.723	0.36
302_T	443_V	0.723	0.36
114_T	390_P	0.723	0.36
94_V	98_V	0.722	0.36
87_L	142_F	0.722	0.36
726_I	730_M	0.722	0.36
151_E	701_K	0.721	0.36
192_V	319_I	0.720	0.36
391_K	395_A	0.719	0.36
66_L	70_L	0.718	0.36
426_A	493_G	0.716	0.35
71_K	75_A	0.716	0.35
515_I	543_L	0.715	0.35
189_G	304_A	0.714	0.35
173_V	614_F	0.713	0.35
250_V	315_G	0.712	0.35
598_V	601_V	0.712	0.35
40_K	355_D	0.712	0.35
563_N	573_I	0.712	0.35
482_K	600_Q	0.711	0.35
457_L	586_D	0.711	0.35
416_N	420_Y	0.711	0.35
767_I	853_R	0.711	0.35
812_L	867_I	0.710	0.35
845_A	865_C	0.710	0.35
28_A	67_A	0.709	0.35
102_A	642_L	0.708	0.35
203_A	344_A	0.707	0.35
158_V	624_N	0.707	0.35
40_K	352_N	0.707	0.35
461_R	559_A	0.706	0.35
194_S	199_G	0.705	0.35
224_L	292_L	0.705	0.35
791_R	834_D	0.703	0.34
86_V	236_A	0.702	0.34
752_D	755_M	0.702	0.34
26_P	346_A	0.702	0.34
390_P	566_I	0.701	0.34
316_F	357_P	0.701	0.34
180_C	189_G	0.701	0.34
102_A	105_E	0.700	0.34
661_G	852_T	0.700	0.34
767_I	861_V	0.699	0.34
742_L	830_E	0.699	0.34
730_M	851_L	0.698	0.34
571_E	807_I	0.698	0.34
815_E	818_Q	0.697	0.34
660_H	836_G	0.697	0.34
41_S	359_F	0.696	0.34
216_T	304_A	0.696	0.34
852_T	856_G	0.695	0.34
686_D	691_R	0.695	0.34
160_L	505_I	0.695	0.34
746_D	759_Q	0.695	0.34
411_V	415_M	0.694	0.34
411_V	518_A	0.693	0.34
527_G	548_W	0.692	0.34
664_I	851_L	0.692	0.34
874_T	886_I	0.692	0.34
638_T	698_V	0.692	0.34
324_L	328_R	0.692	0.34
173_V	616_G	0.691	0.34
277_K	682_S	0.691	0.34
302_T	440_N	0.690	0.34
505_I	777_S	0.689	0.34
218_I	315_G	0.689	0.34
257_K	652_T	0.688	0.33
25_L	347_Q	0.688	0.33
606_F	706_Y	0.688	0.33
671_S	771_E	0.687	0.33
44_V	785_P	0.687	0.33
81_Y	180_C	0.687	0.33
796_E	819_G	0.686	0.33
540_I	672_V	0.685	0.33
121_S	563_N	0.685	0.33
792_V	811_I	0.684	0.33
290_D	353_P	0.683	0.33
667_M	826_G	0.682	0.33
422_L	428_V	0.682	0.33
80_A	871_T	0.682	0.33
185_L	312_A	0.681	0.33
40_K	351_R	0.681	0.33
427_V	564_M	0.681	0.33
222_G	300_R	0.679	0.33
253_K	362_T	0.679	0.33
381_Q	708_S	0.678	0.33
132_T	468_S	0.678	0.33
224_L	344_A	0.678	0.33
516_E	548_W	0.677	0.33
48_N	82_R	0.677	0.33
142_F	150_M	0.676	0.33
240_Q	886_I	0.676	0.33
46_L	63_I	0.676	0.33
136_F	515_I	0.675	0.33
445_M	455_V	0.673	0.32
526_V	543_L	0.673	0.32
869_T	889_M	0.673	0.32
13_L	346_A	0.672	0.32
192_V	343_Y	0.672	0.32
758_K	791_R	0.671	0.32
272_T	367_M	0.669	0.32
81_Y	87_L	0.669	0.32
368_N	648_E	0.669	0.32
113_D	116_K	0.669	0.32
469_L	486_T	0.668	0.32
847_V	865_C	0.667	0.32
290_D	357_P	0.667	0.32
107_V	114_T	0.667	0.32
91_F	646_F	0.667	0.32
833_I	851_L	0.666	0.32
379_R	671_S	0.666	0.32
659_I	763_P	0.665	0.32
830_E	853_R	0.664	0.32
270_T	370_V	0.663	0.32
646_F	720_T	0.663	0.32
645_F	883_H	0.662	0.32
452_K	605_M	0.662	0.32
57_S	871_T	0.661	0.32
252_F	462_Q	0.661	0.32
138_D	144_E	0.660	0.31
684_K	867_I	0.659	0.31
260_E	590_S	0.659	0.31
75_A	248_D	0.659	0.31
734_V	740_R	0.658	0.31
798_F	834_D	0.656	0.31
113_D	634_Q	0.656	0.31
707_G	720_T	0.656	0.31
33_G	672_V	0.655	0.31
573_I	581_P	0.655	0.31
288_Y	484_K	0.655	0.31
132_T	236_A	0.655	0.31
553_P	594_I	0.654	0.31
70_L	75_A	0.653	0.31
157_Y	170_F	0.653	0.31
409_Q	824_T	0.652	0.31
163_G	869_T	0.651	0.31
415_M	418_H	0.651	0.31
416_N	517_T	0.651	0.31
359_F	798_F	0.651	0.31
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364_E	634_Q	0.650	0.31
351_R	357_P	0.648	0.31
497_V	510_P	0.648	0.31
767_I	798_F	0.647	0.31
416_N	419_Q	0.647	0.31
224_L	246_I	0.646	0.31
22_Y	26_P	0.646	0.31
742_L	748_V	0.646	0.31
664_I	822_R	0.645	0.30
58_V	62_D	0.644	0.30
57_S	81_Y	0.644	0.30
767_I	849_V	0.643	0.30
634_Q	641_R	0.642	0.30
218_I	222_G	0.642	0.30
444_L	631_Y	0.642	0.30
40_K	112_G	0.642	0.30
236_A	244_M	0.642	0.30
163_G	245_L	0.642	0.30
415_M	419_Q	0.641	0.30
38_L	46_L	0.641	0.30
656_V	838_L	0.639	0.30
43_K	347_Q	0.637	0.30
455_V	461_R	0.636	0.30
263_T	475_V	0.635	0.30
866_R	876_Y	0.634	0.30
540_I	634_Q	0.633	0.30
199_G	202_I	0.633	0.30
254_L	295_L	0.633	0.30
767_I	863_C	0.633	0.30
194_S	336_Q	0.632	0.30
43_K	357_P	0.632	0.30
413_Y	420_Y	0.632	0.30
157_Y	164_K	0.631	0.30
53_Q	163_G	0.631	0.30
27_L	207_T	0.631	0.30
445_M	601_V	0.630	0.29
631_Y	640_I	0.630	0.29
296_P	444_L	0.630	0.29
17_D	623_I	0.630	0.29
297_L	301_A	0.629	0.29
150_M	621_K	0.629	0.29
273_Q	373_S	0.629	0.29
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148_L	701_K	0.629	0.29
742_L	828_T	0.628	0.29
337_V	521_K	0.628	0.29
207_T	878_N	0.627	0.29
410_P	421_Q	0.627	0.29
541_H	548_W	0.626	0.29
149_E	216_T	0.626	0.29
62_D	65_A	0.626	0.29
300_R	320_D	0.625	0.29
470_A	692_Y	0.624	0.29
116_K	120_L	0.624	0.29
159_F	242_V	0.623	0.29
662_A	763_P	0.622	0.29
689_A	693_L	0.622	0.29
273_Q	363_L	0.621	0.29
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445_M	594_I	0.620	0.29
422_L	759_Q	0.619	0.29
297_L	613_V	0.619	0.29
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282_G	687_S	0.619	0.29
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571_E	576_D	0.618	0.29
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573_I	665_L	0.615	0.29
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428_V	512_P	0.615	0.29
615_E	672_V	0.614	0.28
423_P	426_A	0.614	0.28
146_V	617_T	0.614	0.28
25_L	67_A	0.614	0.28
296_P	322_V	0.613	0.28
409_Q	672_V	0.613	0.28
141_A	626_T	0.613	0.28
525_T	713_H	0.612	0.28
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515_I	520_K	0.611	0.28
359_F	724_I	0.610	0.28
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42_L	246_I	0.609	0.28
108_K	452_K	0.608	0.28
48_N	617_T	0.607	0.28
605_M	751_Y	0.607	0.28
379_R	771_E	0.605	0.28
444_L	597_A	0.605	0.28
32_L	43_K	0.605	0.28
730_M	861_V	0.605	0.28
180_C	190_K	0.604	0.28
141_A	622_G	0.604	0.28
144_E	359_F	0.604	0.28
550_A	724_I	0.604	0.28
135_R	148_L	0.604	0.28
130_S	704_N	0.603	0.28
268_V	303_I	0.603	0.28
62_D	290_D	0.603	0.28
321_A	570_S	0.603	0.28
161_K	624_N	0.602	0.28
663_R	742_L	0.602	0.28
664_I	730_M	0.601	0.28
875_Y	884_Y	0.601	0.28
56_N	871_T	0.599	0.27
44_V	349_M	0.598	0.27
350_W	355_D	0.598	0.27
383_R	424_D	0.598	0.27
450_L	587_I	0.598	0.27
462_Q	465_V	0.598	0.27
426_A	566_I	0.597	0.27
91_F	180_C	0.597	0.27
146_V	157_Y	0.597	0.27
515_I	764_L	0.597	0.27
631_Y	634_Q	0.597	0.27
124_D	316_F	0.596	0.27
392_A	594_I	0.596	0.27
22_Y	27_L	0.596	0.27
486_T	861_V	0.595	0.27
321_A	352_N	0.595	0.27
307_S	314_C	0.595	0.27
147_R	151_E	0.595	0.27
288_Y	367_M	0.595	0.27
381_Q	499_Y	0.595	0.27
450_L	573_I	0.595	0.27
274_M	370_V	0.595	0.27
836_G	848_P	0.594	0.27
271_V	770_K	0.594	0.27
668_L	767_I	0.594	0.27
42_L	374_L	0.593	0.27
573_I	587_I	0.593	0.27
46_L	499_Y	0.593	0.27
557_A	573_I	0.593	0.27
115_A	168_S	0.593	0.27
177_T	614_F	0.593	0.27
439_S	610_Y	0.592	0.27
645_F	649_M	0.592	0.27
23_Y	50_L	0.592	0.27
727_R	731_V	0.592	0.27
682_S	708_S	0.591	0.27
218_I	223_V	0.590	0.27
163_G	424_D	0.590	0.27
765_A	854_A	0.590	0.27
836_G	860_V	0.590	0.27
161_K	837_D	0.590	0.27
164_K	690_G	0.589	0.27
816_F	819_G	0.589	0.27
698_V	835_I	0.588	0.27
583_Y	628_S	0.588	0.27
243_S	884_Y	0.588	0.27
15_A	338_E	0.587	0.27
218_I	842_Q	0.587	0.27
176_G	609_E	0.587	0.27
315_G	444_L	0.586	0.27
664_I	830_E	0.586	0.27
97_V	159_F	0.586	0.27
486_T	849_V	0.585	0.27
79_I	869_T	0.585	0.27
631_Y	755_M	0.585	0.27
123_V	541_H	0.584	0.27
112_G	116_K	0.583	0.27
118_N	127_I	0.583	0.27
695_G	834_D	0.582	0.26
78_E	103_M	0.582	0.26
59_T	62_D	0.582	0.26
474_K	608_K	0.582	0.26
738_M	747_V	0.582	0.26
323_T	713_H	0.582	0.26
159_F	538_G	0.581	0.26
58_V	427_V	0.581	0.26
510_P	515_I	0.581	0.26
154_H	624_N	0.581	0.26
252_F	288_Y	0.580	0.26
820_V	825_L	0.580	0.26
683_I	750_I	0.579	0.26
252_F	278_H	0.579	0.26
643_S	647_D	0.579	0.26
743_P	760_E	0.578	0.26
89_Q	646_F	0.578	0.26
161_K	272_T	0.578	0.26
147_R	346_A	0.578	0.26
48_N	837_D	0.578	0.26
814_L	863_C	0.578	0.26
167_F	172_V	0.577	0.26
662_A	765_A	0.577	0.26
321_A	324_L	0.577	0.26
262_I	387_P	0.576	0.26
42_L	389_V	0.576	0.26
403_A	406_K	0.576	0.26
189_G	886_I	0.576	0.26
800_R	805_N	0.575	0.26
24_S	27_L	0.575	0.26
729_E	811_I	0.575	0.26
744_D	748_V	0.573	0.26
75_A	180_C	0.573	0.26
189_G	225_G	0.573	0.26
824_T	855_D	0.572	0.26
49_L	66_L	0.572	0.26
48_N	53_Q	0.572	0.26
869_T	872_E	0.572	0.26
816_F	821_T	0.571	0.26
96_A	133_V	0.571	0.26
69_W	743_P	0.571	0.26
244_M	268_V	0.571	0.26
763_P	837_D	0.571	0.26
291_G	808_G	0.571	0.26
62_D	523_D	0.570	0.26
851_L	858_Q	0.570	0.26
96_A	208_L	0.570	0.26
268_V	617_T	0.569	0.26
771_E	838_L	0.569	0.26
146_V	177_T	0.569	0.26
274_M	278_H	0.568	0.26
89_Q	132_T	0.567	0.26
136_F	766_V	0.567	0.26
740_R	745_S	0.567	0.26
341_E	350_W	0.566	0.25
505_I	875_Y	0.566	0.25
132_T	634_Q	0.566	0.25
107_V	498_G	0.565	0.25
530_L	547_N	0.564	0.25
847_V	862_P	0.564	0.25
375_A	427_V	0.564	0.25
109_R	645_F	0.564	0.25
70_L	870_A	0.564	0.25
209_V	291_G	0.564	0.25
208_L	218_I	0.564	0.25
151_E	398_E	0.564	0.25
50_L	53_Q	0.563	0.25
649_M	653_P	0.563	0.25
259_R	387_P	0.563	0.25
477_S	496_L	0.563	0.25
389_V	392_A	0.562	0.25
159_F	446_A	0.562	0.25
244_M	616_G	0.562	0.25
350_W	462_Q	0.562	0.25
344_A	349_M	0.562	0.25
548_W	564_M	0.561	0.25
15_A	19_T	0.561	0.25
103_M	505_I	0.561	0.25
101_A	272_T	0.561	0.25
176_G	623_I	0.561	0.25
329_L	337_V	0.561	0.25
653_P	867_I	0.561	0.25
743_P	762_T	0.561	0.25
762_T	798_F	0.560	0.25
486_T	851_L	0.560	0.25
142_F	519_I	0.559	0.25
407_D	424_D	0.559	0.25
767_I	821_T	0.559	0.25
87_L	545_K	0.559	0.25
730_M	853_R	0.559	0.25
50_L	207_T	0.559	0.25
868_D	876_Y	0.559	0.25
560_L	576_D	0.558	0.25
431_A	541_H	0.558	0.25
121_S	871_T	0.558	0.25
569_A	762_T	0.558	0.25
601_V	605_M	0.558	0.25
26_P	29_A	0.557	0.25
61_E	257_K	0.555	0.25
84_A	341_E	0.555	0.25
163_G	166_A	0.554	0.25
265_T	438_T	0.554	0.25
157_Y	381_Q	0.554	0.25
396_S	890_L	0.554	0.25
798_F	843_P	0.554	0.25
106_A	726_I	0.553	0.25
616_G	623_I	0.553	0.25
817_P	863_C	0.553	0.25
457_L	581_P	0.553	0.25
822_R	861_V	0.553	0.25
741_H	746_D	0.553	0.25
298_A	538_G	0.552	0.25
347_Q	383_R	0.552	0.25
78_E	809_M	0.552	0.25
448_G	480_L	0.551	0.25
290_D	548_W	0.551	0.25
234_E	681_G	0.551	0.25
812_L	838_L	0.550	0.25
98_V	711_G	0.550	0.25
396_S	568_L	0.550	0.25
665_L	668_L	0.550	0.25
252_F	273_Q	0.548	0.24
524_L	725_R	0.548	0.24
394_A	452_K	0.548	0.24
716_M	719_G	0.547	0.24
124_D	176_G	0.547	0.24
43_K	550_A	0.547	0.24
497_V	508_S	0.547	0.24
666_A	737_G	0.546	0.24
732_P	740_R	0.546	0.24
41_S	314_C	0.546	0.24
120_L	659_I	0.546	0.24
730_M	830_E	0.546	0.24
319_I	372_A	0.546	0.24
371_E	653_P	0.545	0.24
208_L	645_F	0.545	0.24
157_Y	774_S	0.544	0.24
431_A	683_I	0.544	0.24
692_Y	751_Y	0.543	0.24
648_E	887_R	0.543	0.24
680_A	719_G	0.543	0.24
505_I	708_S	0.542	0.24
690_G	764_L	0.542	0.24
69_W	633_W	0.542	0.24
218_I	330_S	0.542	0.24
120_L	885_V	0.542	0.24
136_F	304_A	0.541	0.24
768_A	791_R	0.541	0.24
613_V	717_M	0.541	0.24
25_L	28_A	0.541	0.24
98_V	645_F	0.541	0.24
496_L	568_L	0.540	0.24
346_A	349_M	0.540	0.24
304_A	314_C	0.540	0.24
549_L	719_G	0.540	0.24
110_L	878_N	0.540	0.24
290_D	602_S	0.540	0.24
651_A	890_L	0.539	0.24
161_K	165_Q	0.539	0.24
537_E	707_G	0.539	0.24
134_D	737_G	0.538	0.24
278_H	288_Y	0.538	0.24
172_V	323_T	0.538	0.24
250_V	656_V	0.538	0.24
796_E	822_R	0.538	0.24
682_S	766_V	0.538	0.24
243_S	871_T	0.538	0.24
124_D	843_P	0.538	0.24
116_K	889_M	0.537	0.24
53_Q	645_F	0.537	0.24
329_L	336_Q	0.537	0.24
766_V	774_S	0.537	0.24
265_T	437_N	0.536	0.24
218_I	598_V	0.536	0.24
255_T	370_V	0.536	0.24
660_H	791_R	0.536	0.24
180_C	193_W	0.536	0.24
284_F	314_C	0.535	0.24
827_L	854_A	0.535	0.24
573_I	873_L	0.535	0.24
207_T	502_T	0.535	0.24
834_D	860_V	0.535	0.24
103_M	889_M	0.534	0.24
475_V	610_Y	0.534	0.24
42_L	464_W	0.533	0.24
609_E	613_V	0.533	0.24
507_N	680_A	0.533	0.24
636_D	828_T	0.533	0.24
110_L	650_Q	0.533	0.24
263_T	553_P	0.532	0.23
216_T	314_C	0.532	0.23
558_Y	865_C	0.532	0.23
185_L	297_L	0.532	0.23
103_M	680_A	0.532	0.23
444_L	480_L	0.531	0.23
870_A	874_T	0.531	0.23
750_I	766_V	0.531	0.23
262_I	495_N	0.531	0.23
92_T	707_G	0.531	0.23
44_V	295_L	0.531	0.23
281_V	313_T	0.531	0.23
15_A	203_A	0.531	0.23
848_P	859_E	0.530	0.23
407_D	410_P	0.530	0.23
312_A	643_S	0.530	0.23
146_V	726_I	0.530	0.23
157_Y	177_T	0.530	0.23
445_M	528_A	0.529	0.23
765_A	817_P	0.529	0.23
827_L	833_I	0.529	0.23
96_A	236_A	0.529	0.23
491_E	890_L	0.529	0.23
428_V	519_I	0.529	0.23
727_R	838_L	0.528	0.23
375_A	383_R	0.528	0.23
278_H	672_V	0.527	0.23
843_P	870_A	0.527	0.23
126_V	173_V	0.527	0.23
349_M	598_V	0.527	0.23
565_N	851_L	0.527	0.23
288_Y	297_L	0.527	0.23
224_L	298_A	0.527	0.23
378_K	731_V	0.526	0.23
503_T	508_S	0.526	0.23
671_S	732_P	0.526	0.23
108_K	114_T	0.526	0.23
381_Q	771_E	0.525	0.23
165_Q	729_E	0.525	0.23
132_T	161_K	0.524	0.23
43_K	538_G	0.524	0.23
79_I	752_D	0.523	0.23
339_L	359_F	0.523	0.23
74_H	360_T	0.523	0.23
110_L	653_P	0.523	0.23
163_G	303_I	0.522	0.23
252_F	315_G	0.522	0.23
671_S	705_S	0.522	0.23
513_D	608_K	0.521	0.23
566_I	706_Y	0.521	0.23
804_S	808_G	0.521	0.23
80_A	121_S	0.521	0.23
21_H	890_L	0.520	0.23
115_A	708_S	0.520	0.23
304_A	774_S	0.519	0.23
18_K	349_M	0.519	0.23
279_G	712_N	0.518	0.23
130_S	505_I	0.518	0.23
527_G	541_H	0.518	0.23
176_G	542_P	0.518	0.23
368_N	748_V	0.518	0.23
86_V	160_L	0.518	0.23
390_P	570_S	0.518	0.23
132_T	774_S	0.518	0.23
139_D	490_D	0.517	0.23
209_V	442_S	0.517	0.23
270_T	527_G	0.517	0.23
335_D	655_P	0.517	0.23
523_D	526_V	0.517	0.23
140_E	143_E	0.516	0.23
766_V	818_Q	0.516	0.23
362_T	483_A	0.516	0.23
254_L	287_F	0.515	0.23
482_K	640_I	0.515	0.23
684_K	738_M	0.515	0.23
683_I	749_S	0.515	0.23
110_L	649_M	0.515	0.23
274_M	369_D	0.515	0.23
721_F	766_V	0.514	0.22
429_I	503_T	0.514	0.22
756_R	791_R	0.514	0.22
240_Q	871_T	0.514	0.22
484_K	488_Y	0.514	0.22
559_A	705_S	0.514	0.22
716_M	780_W	0.513	0.22
224_L	613_V	0.513	0.22
274_M	587_I	0.513	0.22
48_N	631_Y	0.513	0.22
252_F	601_V	0.512	0.22
587_I	631_Y	0.512	0.22
117_V	626_T	0.512	0.22
491_E	577_R	0.512	0.22
28_A	34_D	0.512	0.22
79_I	684_K	0.511	0.22
375_A	870_A	0.511	0.22
259_R	369_D	0.511	0.22
56_N	236_A	0.511	0.22
717_M	726_I	0.511	0.22
87_L	224_L	0.510	0.22
626_T	697_G	0.510	0.22
379_R	547_N	0.510	0.22
243_S	298_A	0.510	0.22
134_D	429_I	0.510	0.22
91_F	505_I	0.510	0.22
20_Y	177_T	0.510	0.22
324_L	364_E	0.510	0.22
50_L	737_G	0.509	0.22
666_A	823_K	0.509	0.22
683_I	748_V	0.508	0.22
76_D	844_G	0.508	0.22
341_E	344_A	0.508	0.22
105_E	641_R	0.508	0.22
849_V	862_P	0.508	0.22
116_K	168_S	0.508	0.22
452_K	582_V	0.508	0.22
722_A	737_G	0.507	0.22
108_K	113_D	0.507	0.22
507_N	707_G	0.507	0.22
89_Q	126_V	0.507	0.22
110_L	890_L	0.507	0.22
221_L	873_L	0.507	0.22
316_F	865_C	0.507	0.22
139_D	657_E	0.506	0.22
236_A	871_T	0.506	0.22
272_T	349_M	0.505	0.22
35_I	43_K	0.505	0.22
540_I	649_M	0.505	0.22
574_G	587_I	0.505	0.22
609_E	612_E	0.505	0.22
429_I	470_A	0.505	0.22
698_V	703_F	0.504	0.22
431_A	890_L	0.504	0.22
13_L	22_Y	0.504	0.22
127_I	583_Y	0.504	0.22
68_G	113_D	0.503	0.22
268_V	462_Q	0.503	0.22
394_A	580_D	0.503	0.22
363_L	654_A	0.503	0.22
572_P	575_H	0.502	0.22
518_A	567_N	0.502	0.22
41_S	79_I	0.501	0.22
791_R	877_Q	0.501	0.22
497_V	528_A	0.500	0.22
816_F	822_R	0.500	0.22
103_M	393_F	0.500	0.22
121_S	209_V	0.500	0.22
599_E	604_E	0.500	0.22
182_Q	238_L	0.500	0.22
180_C	272_T	0.500	0.22

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2b3yA	1	0.9843	100	0.284	Contact Map
1c96A	1	0.8305	100	0.505	Contact Map
4kp2A	2	0.4669	100	0.707	Contact Map
4kp1A	1	0.4669	100	0.715	Contact Map
1l5jA	1	0.5679	100	0.733	Contact Map
3vbaA	2	0.1863	100	0.913	Contact Map
2pkpA	2	0.1818	100	0.913	Contact Map
1v7lA	6	0.1796	100	0.915	Contact Map
2hcuA	1	0.1942	100	0.918	Contact Map
3q3wA	1	0.1987	100	0.923	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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