FRMA - ECOLI - GREMLIN Contacts

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FRMA - S-(hydroxymethyl)glutathione dehydrogenase

UniProt:	P25437	Sequences: MKSRAAVAFAPGKPLEIVEIDVAPPKKGEVLIKVTHTGVCHTDAFTLSGDDPEGVFPVVLGHEGAGVVVEVGEGVTSVKPGDHVIPLYTAECGECEFCRSGKTNLCVAVRETQGKGLMPDGTTRFSYNGQPLYHYMGCSTFSEYTVVAEVSLAKINPEANHEHVCLLGCGVTTGIGAVHNTAKVQPGDSVAVFGLGAIGLAVVQGARQAKAGRIIAIDTNPKKFDLARRFGATDCINPNDYDKPIKDVLLDINKWGIDHTFECIGNVNVMRAALESAHRGWGQSVIIGVAVAGQEISTRPFQLVTGRVWKGSAFGGVKGRSQLPGMVEDAMKGDIDLEPFVTHTMSLDEINDAFDLMHEGKSIRTVIRY	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG50010
Length:	369 (327)
Sequences:	35149 (23546)
Seq/√Len:	1302.1

ECOLI - FRMA YBDR YGGP YDJJ YAHK YDJL GATD RSPB YPHC AHR YJJN TDH ADHP IDND QOR1 YCJQ ACUI CURA
BACSU - ADHB YJMD YYCR DHSO ADHA TDH BDHA YOGA YHFP YFMJ
HALSA - Q9HP38 Q9HMB6 GLCDH Q9HQS8 Q9HR85
SULSO - Q97ZV3 Q97VV5 ADH Q7LXK1 Q97YT7 Q97XR4 Q97V32 Q97VW0 Q97TZ4 Q97WA1 Q97YM2 GLCD1 GLCD2 GLCD3 Q97W06 Q97VB8 Q97UW5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
33_K	69_V	3.039	1.00
35_T	161_H	3.021	1.00
35_T	67_V	2.971	1.00
349_E	352_D	2.966	1.00
9_F	18_V	2.854	1.00
189_S	213_R	2.782	1.00
31_L	69_V	2.623	1.00
30_V	152_L	2.578	1.00
64_G	140_T	2.519	1.00
82_D	154_K	2.492	1.00
160_N	163_H	2.464	1.00
9_F	16_E	2.452	1.00
207_R	233_T	2.447	1.00
224_F	228_R	2.399	1.00
185_Q	188_D	2.377	1.00
162_E	344_T	2.301	1.00
98_C	106_C	2.283	1.00
345_M	356_L	2.262	1.00
343_H	356_L	2.235	1.00
213_R	234_D	2.219	1.00
83_H	155_I	2.214	1.00
27_K	73_E	2.190	1.00
28_G	74_G	2.188	1.00
33_K	67_V	2.176	1.00
195_L	216_A	2.175	1.00
48_S	358_H	2.172	1.00
225_D	229_R	2.159	1.00
346_S	349_E	2.139	1.00
355_D	359_E	2.133	1.00
33_K	144_Y	2.127	1.00
27_K	74_G	2.105	1.00
77_S	149_E	2.097	1.00
7_V	18_V	2.082	1.00
158_E	331_M	2.079	1.00
79_K	82_D	2.069	1.00
22_V	144_Y	2.051	1.00
283_Q	308_V	2.029	1.00
328_E	332_K	2.012	1.00
83_H	161_H	1.965	1.00
190_V	206_A	1.940	1.00
191_A	257_I	1.895	1.00
65_A	161_H	1.879	1.00
247_D	250_L	1.867	1.00
163_H	338_E	1.819	1.00
179_H	325_G	1.805	1.00
277_A	284_S	1.801	1.00
69_V	144_Y	1.798	1.00
283_Q	310_K	1.789	1.00
26_K	29_E	1.786	1.00
225_D	228_R	1.785	1.00
64_G	86_P	1.779	1.00
226_L	229_R	1.773	1.00
155_I	164_V	1.772	1.00
179_H	209_A	1.768	1.00
24_P	70_E	1.761	1.00
31_L	146_V	1.740	1.00
191_A	217_I	1.740	1.00
345_M	353_A	1.739	1.00
215_I	257_I	1.714	1.00
224_F	235_C	1.709	1.00
352_D	355_D	1.694	1.00
203_V	232_A	1.692	1.00
356_L	361_K	1.671	1.00
213_R	233_T	1.659	1.00
260_T	277_A	1.651	1.00
258_D	278_H	1.644	1.00
221_P	225_D	1.638	1.00
4_R	19_E	1.630	1.00
241_Y	247_D	1.629	1.00
352_D	356_L	1.623	1.00
229_R	339_P	1.604	1.00
70_E	80_P	1.596	1.00
351_N	355_D	1.586	1.00
6_A	350_I	1.581	1.00
78_V	154_K	1.578	1.00
221_P	237_N	1.559	1.00
71_V	80_P	1.543	1.00
34_V	64_G	1.534	1.00
31_L	144_Y	1.530	1.00
155_I	161_H	1.526	1.00
260_T	273_A	1.523	1.00
277_A	307_R	1.485	1.00
4_R	348_D	1.485	1.00
208_Q	334_D	1.466	1.00
72_G	75_V	1.463	1.00
328_E	331_M	1.447	1.00
25_P	146_V	1.442	1.00
193_F	273_A	1.442	1.00
83_H	157_P	1.441	1.00
67_V	83_H	1.434	1.00
171_V	201_A	1.430	1.00
36_H	162_E	1.422	1.00
277_A	282_G	1.417	1.00
28_G	148_A	1.417	1.00
237_N	240_D	1.414	1.00
221_P	240_D	1.407	1.00
219_T	238_P	1.396	1.00
78_V	82_D	1.392	1.00
67_V	161_H	1.391	1.00
6_A	17_I	1.390	1.00
68_V	78_V	1.385	1.00
202_V	261_F	1.383	1.00
141_F	354_F	1.381	1.00
31_L	70_E	1.375	1.00
29_E	146_V	1.374	1.00
25_P	31_L	1.372	1.00
29_E	148_A	1.367	1.00
22_V	31_L	1.363	1.00
4_R	143_E	1.343	1.00
203_V	216_A	1.342	1.00
336_D	339_P	1.337	1.00
5_A	20_I	1.325	1.00
221_P	224_F	1.309	1.00
218_D	224_F	1.308	1.00
247_D	251_D	1.301	1.00
167_L	330_A	1.293	1.00
189_S	215_I	1.275	1.00
30_V	78_V	1.266	1.00
188_D	283_Q	1.261	1.00
182_A	259_H	1.258	1.00
28_G	149_E	1.235	1.00
10_A	13_K	1.215	1.00
246_K	250_L	1.206	1.00
78_V	152_L	1.197	1.00
264_I	269_V	1.194	1.00
275_E	302_Q	1.192	1.00
47_L	354_F	1.187	1.00
228_R	235_C	1.158	1.00
34_V	145_T	1.156	1.00
189_S	258_D	1.152	1.00
193_F	217_I	1.145	1.00
32_I	84_V	1.140	1.00
181_T	308_V	1.138	1.00
39_V	353_A	1.137	1.00
35_T	83_H	1.131	1.00
195_L	218_D	1.128	1.00
224_F	237_N	1.121	1.00
174_G	202_V	1.115	1.00
219_T	224_F	1.114	1.00
7_V	20_I	1.109	1.00
208_Q	329_D	1.103	1.00
69_V	80_P	1.102	1.00
234_D	251_D	1.101	1.00
179_H	322_Q	1.099	1.00
25_P	29_E	1.095	1.00
188_D	258_D	1.095	1.00
159_A	164_V	1.090	1.00
325_G	328_E	1.087	1.00
184_V	188_D	1.080	1.00
188_D	259_H	1.080	1.00
36_H	161_H	1.078	1.00
324_P	328_E	1.074	1.00
355_D	358_H	1.065	1.00
9_F	14_P	1.061	1.00
58_V	138_C	1.060	1.00
37_T	140_T	1.059	1.00
6_A	347_L	1.058	1.00
191_A	276_S	1.050	1.00
32_I	66_G	1.041	1.00
141_F	350_I	1.038	1.00
20_I	138_C	1.037	1.00
107_V	279_R	1.035	1.00
10_A	14_P	1.030	1.00
271_R	275_E	1.018	1.00
171_V	326_M	1.017	1.00
17_I	348_D	1.017	1.00
44_A	357_M	1.011	1.00
20_I	59_V	1.005	1.00
22_V	70_E	1.004	1.00
216_A	227_A	1.004	1.00
35_T	65_A	1.003	1.00
176_G	322_Q	1.000	1.00
362_S	365_T	0.998	1.00
195_L	203_V	0.998	1.00
345_M	349_E	0.992	1.00
219_T	239_N	0.992	1.00
177_A	287_I	0.990	1.00
217_I	238_P	0.988	1.00
273_A	284_S	0.982	1.00
216_A	232_A	0.982	1.00
174_G	205_G	0.979	1.00
7_V	59_V	0.977	1.00
102_K	280_G	0.976	1.00
175_I	179_H	0.973	1.00
184_V	211_A	0.970	1.00
182_A	285_V	0.964	1.00
342_T	356_L	0.963	1.00
37_T	141_F	0.963	1.00
215_I	234_D	0.962	1.00
76_T	149_E	0.958	1.00
147_V	152_L	0.958	1.00
220_N	223_K	0.954	1.00
204_Q	336_D	0.954	1.00
64_G	145_T	0.952	1.00
192_V	206_A	0.952	1.00
33_K	143_E	0.951	1.00
205_G	326_M	0.948	1.00
47_L	358_H	0.946	1.00
193_F	269_V	0.930	1.00
242_D	246_K	0.930	1.00
271_R	295_E	0.920	1.00
252_I	255_W	0.918	1.00
6_A	15_L	0.915	1.00
222_K	225_D	0.913	1.00
203_V	214_I	0.905	1.00
5_A	59_V	0.900	1.00
329_D	334_D	0.899	1.00
242_D	247_D	0.897	1.00
71_V	79_K	0.895	1.00
218_D	235_C	0.891	1.00
228_R	234_D	0.885	1.00
262_E	265_G	0.881	1.00
22_V	69_V	0.874	1.00
260_T	284_S	0.872	1.00
272_A	275_E	0.870	1.00
40_C	62_H	0.864	1.00
3_S	22_V	0.864	1.00
40_C	63_E	0.861	1.00
86_P	147_V	0.858	1.00
226_L	363_I	0.858	1.00
245_I	275_E	0.856	1.00
79_K	154_K	0.854	1.00
206_A	211_A	0.851	1.00
240_D	247_D	0.849	1.00
177_A	261_F	0.846	1.00
362_S	366_V	0.842	1.00
183_K	283_Q	0.840	1.00
30_V	149_E	0.839	1.00
156_N	331_M	0.839	1.00
181_T	310_K	0.837	1.00
325_G	329_D	0.837	1.00
302_Q	305_T	0.832	1.00
215_I	236_I	0.829	1.00
190_V	211_A	0.826	1.00
193_F	260_T	0.825	1.00
245_I	272_A	0.823	1.00
153_A	324_P	0.819	1.00
140_T	145_T	0.815	1.00
223_K	363_I	0.815	1.00
71_V	75_V	0.814	1.00
11_P	56_F	0.811	1.00
329_D	333_G	0.810	1.00
195_L	227_A	0.809	1.00
280_G	306_G	0.803	1.00
266_N	269_V	0.799	1.00
75_V	149_E	0.796	1.00
6_A	351_N	0.792	1.00
303_L	309_W	0.792	1.00
341_V	344_T	0.789	1.00
174_G	201_A	0.787	1.00
178_V	206_A	0.782	1.00
28_G	73_E	0.780	1.00
189_S	257_I	0.779	1.00
267_V	271_R	0.779	1.00
85_I	327_V	0.778	1.00
174_G	198_I	0.776	1.00
24_P	31_L	0.773	1.00
175_I	326_M	0.770	1.00
176_G	306_G	0.766	1.00
84_V	152_L	0.764	1.00
219_T	227_A	0.762	1.00
257_I	260_T	0.760	1.00
174_G	178_V	0.759	1.00
39_V	357_M	0.757	1.00
3_S	23_A	0.754	1.00
244_P	248_V	0.754	1.00
65_A	165_C	0.750	1.00
26_K	146_V	0.749	1.00
320_R	324_P	0.748	1.00
192_V	202_V	0.747	1.00
214_I	233_T	0.746	1.00
28_G	72_G	0.744	1.00
175_I	325_G	0.738	1.00
153_A	327_V	0.737	1.00
38_G	63_E	0.735	1.00
207_R	214_I	0.733	1.00
295_E	299_R	0.733	1.00
286_I	309_W	0.728	1.00
250_L	253_N	0.728	1.00
25_P	70_E	0.724	1.00
157_P	331_M	0.724	1.00
268_N	272_A	0.724	1.00
172_T	322_Q	0.719	1.00
87_L	153_A	0.715	1.00
184_V	259_H	0.714	1.00
107_V	255_W	0.711	1.00
200_L	226_L	0.711	1.00
192_V	216_A	0.711	1.00
82_D	157_P	0.710	1.00
206_A	214_I	0.704	1.00
299_R	302_Q	0.703	1.00
105_L	306_G	0.702	1.00
356_L	359_E	0.700	1.00
271_R	297_S	0.699	1.00
260_T	276_S	0.698	1.00
39_V	141_F	0.695	1.00
4_R	17_I	0.695	1.00
65_A	83_H	0.694	1.00
248_V	257_I	0.694	1.00
163_H	336_D	0.693	1.00
36_H	344_T	0.693	1.00
327_V	331_M	0.692	1.00
245_I	276_S	0.689	1.00
61_G	141_F	0.683	1.00
354_F	358_H	0.682	1.00
294_Q	297_S	0.682	1.00
343_H	352_D	0.677	1.00
83_H	158_E	0.675	1.00
32_I	86_P	0.675	1.00
54_G	58_V	0.671	1.00
279_R	305_T	0.670	1.00
183_K	310_K	0.669	1.00
262_E	284_S	0.668	1.00
153_A	323_L	0.668	1.00
110_R	137_G	0.666	1.00
259_H	285_V	0.665	1.00
321_S	325_G	0.665	1.00
177_A	285_V	0.663	1.00
38_G	165_C	0.659	1.00
17_I	347_L	0.658	1.00
329_D	332_K	0.657	1.00
177_A	202_V	0.655	1.00
170_G	201_A	0.655	1.00
28_G	150_V	0.654	1.00
259_H	283_Q	0.647	1.00
236_I	244_P	0.647	1.00
42_T	62_H	0.646	1.00
303_L	307_R	0.644	1.00
211_A	214_I	0.644	1.00
85_I	155_I	0.643	1.00
23_A	146_V	0.642	1.00
227_A	232_A	0.640	1.00
41_H	45_F	0.640	1.00
172_T	315_G	0.640	1.00
32_I	152_L	0.640	1.00
215_I	248_V	0.639	1.00
204_Q	230_F	0.639	1.00
3_S	143_E	0.639	1.00
321_S	324_P	0.636	1.00
175_I	329_D	0.634	1.00
30_V	68_V	0.632	1.00
183_K	308_V	0.629	1.00
15_L	354_F	0.628	1.00
190_V	259_H	0.628	1.00
44_A	358_H	0.627	1.00
25_P	72_G	0.626	1.00
285_V	310_K	0.625	1.00
257_I	276_S	0.623	1.00
215_I	251_D	0.623	1.00
173_T	198_I	0.622	1.00
268_N	271_R	0.622	1.00
364_R	367_I	0.618	1.00
178_V	205_G	0.616	1.00
202_V	287_I	0.616	1.00
45_F	50_D	0.616	1.00
77_S	324_P	0.615	1.00
303_L	311_G	0.615	1.00
242_D	272_A	0.614	1.00
192_V	203_V	0.612	1.00
267_V	297_S	0.609	1.00
218_D	238_P	0.609	1.00
36_H	65_A	0.609	1.00
40_C	43_D	0.605	1.00
229_R	336_D	0.604	1.00
312_S	315_G	0.604	1.00
77_S	154_K	0.603	1.00
244_P	272_A	0.600	1.00
207_R	232_A	0.597	1.00
159_A	330_A	0.595	1.00
211_A	259_H	0.595	1.00
42_T	45_F	0.594	1.00
3_S	142_S	0.594	1.00
245_I	248_V	0.594	1.00
8_A	15_L	0.593	1.00
264_I	288_G	0.593	1.00
191_A	260_T	0.592	1.00
269_V	273_A	0.591	1.00
289_V	304_V	0.590	1.00
202_V	263_C	0.590	1.00
175_I	322_Q	0.590	1.00
65_A	155_I	0.590	1.00
322_Q	325_G	0.590	1.00
167_L	326_M	0.589	1.00
21_D	24_P	0.589	1.00
224_F	238_P	0.588	1.00
23_A	144_Y	0.588	1.00
200_L	227_A	0.587	1.00
5_A	142_S	0.586	1.00
77_S	80_P	0.586	1.00
252_I	256_G	0.585	1.00
270_M	286_I	0.584	1.00
173_T	287_I	0.584	1.00
217_I	236_I	0.584	1.00
204_Q	339_P	0.582	1.00
154_K	157_P	0.580	1.00
186_P	210_K	0.579	1.00
262_E	288_G	0.579	1.00
77_S	320_R	0.578	1.00
13_K	48_S	0.574	1.00
71_V	82_D	0.573	1.00
204_Q	335_I	0.572	1.00
23_A	31_L	0.571	1.00
209_A	325_G	0.571	1.00
55_V	58_V	0.570	1.00
46_T	51_D	0.569	1.00
323_L	327_V	0.568	1.00
45_F	289_V	0.567	1.00
203_V	230_F	0.566	1.00
218_D	223_K	0.566	1.00
263_C	287_I	0.566	1.00
22_V	25_P	0.565	1.00
222_K	361_K	0.565	1.00
86_P	152_L	0.562	1.00
262_E	269_V	0.561	1.00
170_G	197_A	0.559	1.00
175_I	209_A	0.556	1.00
62_H	169_C	0.556	1.00
271_R	302_Q	0.555	1.00
236_I	241_Y	0.554	1.00
203_V	207_R	0.551	1.00
186_P	209_A	0.549	1.00
228_R	233_T	0.549	1.00
71_V	78_V	0.549	1.00
78_V	149_E	0.547	1.00
251_D	255_W	0.546	1.00
175_I	205_G	0.544	1.00
159_A	331_M	0.542	1.00
300_P	303_L	0.541	1.00
177_A	312_S	0.541	1.00
11_P	14_P	0.541	1.00
90_A	151_S	0.539	1.00
40_C	169_C	0.539	1.00
208_Q	335_I	0.539	1.00
46_T	58_V	0.538	1.00
251_D	254_K	0.538	1.00
189_S	256_G	0.538	1.00
90_A	148_A	0.537	1.00
242_D	245_I	0.536	1.00
218_D	227_A	0.534	1.00
272_A	276_S	0.533	1.00
168_G	173_T	0.532	1.00
201_A	340_F	0.532	1.00
330_A	337_L	0.532	1.00
36_H	165_C	0.530	1.00
29_E	137_G	0.529	1.00
248_V	276_S	0.528	1.00
68_V	82_D	0.528	1.00
111_E	116_G	0.527	1.00
219_T	237_N	0.527	1.00
345_M	352_D	0.526	1.00
324_P	327_V	0.525	1.00
189_S	234_D	0.525	1.00
88_Y	314_F	0.524	1.00
248_V	252_I	0.524	1.00
236_I	247_D	0.524	1.00
357_M	366_V	0.523	1.00
34_V	140_T	0.523	1.00
356_L	362_S	0.522	1.00
3_S	144_Y	0.522	1.00
10_A	16_E	0.522	1.00
190_V	261_F	0.521	1.00
302_Q	307_R	0.520	1.00
193_F	276_S	0.519	1.00
244_P	247_D	0.519	1.00
203_V	227_A	0.519	1.00
183_K	209_A	0.516	1.00
15_L	60_L	0.516	1.00
167_L	327_V	0.515	1.00
7_V	138_C	0.514	1.00
171_V	205_G	0.513	1.00
274_L	284_S	0.513	1.00
34_V	37_T	0.513	1.00
8_A	56_F	0.511	1.00
178_V	209_A	0.509	1.00
156_N	164_V	0.508	1.00
15_L	351_N	0.508	1.00
353_A	356_L	0.507	1.00
273_A	277_A	0.507	1.00
182_A	283_Q	0.507	1.00
304_V	311_G	0.506	1.00
179_H	205_G	0.506	1.00
201_A	205_G	0.504	1.00
42_T	46_T	0.503	1.00
221_P	239_N	0.502	1.00
204_Q	208_Q	0.502	1.00
8_A	47_L	0.502	1.00
85_I	88_Y	0.502	1.00
237_N	241_Y	0.501	1.00
201_A	204_Q	0.500	1.00
59_V	138_C	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1cdoA	2	0.9946	100	0.151	Contact Map
2fzwA	2	0.9973	100	0.152	Contact Map
3ukoA	4	0.9946	100	0.154	Contact Map
1p0fA	2	0.9892	100	0.157	Contact Map
1e3iA	2	0.9864	100	0.157	Contact Map
2jhfA	2	0.9946	100	0.158	Contact Map
4rqtA	2	0.9973	100	0.165	Contact Map
1f8fA	4	0.9702	100	0.173	Contact Map
1vj0A	4	0.9485	100	0.192	Contact Map
3ip1A	4	0.9106	100	0.202	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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