GREMLIN Database
TEHB - Tellurite methyltransferase
UniProt: P25397 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11884
Length: 197 (157)
Sequences: 24873 (19090)
Seq/√Len: 1523.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_C57_A2.9651.00
62_A84_V2.8061.00
33_K54_D2.7121.00
68_V82_T2.6001.00
56_D96_Y2.5261.00
121_Q163_W2.4291.00
58_W85_V2.2891.00
124_T128_G2.2711.00
56_D83_R2.1511.00
97_D125_K2.1501.00
38_G104_V2.1241.00
35_L96_Y2.1041.00
65_I82_T2.0791.00
120_M130_N2.0201.00
99_I120_M2.0001.00
45_S55_V1.9871.00
119_N122_R1.8941.00
65_I84_V1.8091.00
46_L72_K1.8031.00
32_G98_F1.8001.00
33_K56_D1.7761.00
54_D81_H1.7461.00
62_A66_A1.7331.00
37_L120_M1.7071.00
92_F96_Y1.6951.00
99_I124_T1.6881.00
72_K82_T1.6801.00
114_P118_A1.6391.00
56_D81_H1.6371.00
33_K97_D1.6301.00
37_L87_L1.6211.00
119_N123_C1.6091.00
45_S57_A1.5901.00
50_A75_E1.5771.00
34_T98_F1.5741.00
60_K86_D1.5721.00
46_L71_I1.5681.00
59_D65_I1.5421.00
67_N70_R1.5261.00
29_V32_G1.5131.00
124_T130_N1.4711.00
39_C45_S1.4651.00
33_K125_K1.4511.00
34_T48_L1.4261.00
111_K114_P1.4211.00
114_P159_Y1.4201.00
101_S104_V1.3961.00
157_R161_E1.3711.00
104_V108_L1.3451.00
103_V106_M1.3381.00
36_D39_C1.2911.00
87_L104_V1.2831.00
85_V91_T1.2821.00
124_T163_W1.2761.00
65_I69_E1.2641.00
63_M66_A1.2591.00
106_M134_A1.2451.00
33_K96_Y1.2391.00
47_Y50_A1.2381.00
47_Y51_N1.2361.00
117_I160_Y1.2361.00
103_V107_F1.2341.00
108_L116_L1.2291.00
32_G53_Y1.2231.00
33_K95_Q1.2161.00
111_K159_Y1.2031.00
152_K155_E1.1641.00
59_D64_S1.1591.00
72_K80_L1.1481.00
110_A115_G1.1441.00
21_E24_E1.1281.00
39_C68_V1.1281.00
115_G118_A1.1211.00
83_R92_F1.1121.00
61_N64_S1.1071.00
57_A82_T1.1011.00
93_D122_R1.0901.00
91_T119_N1.0791.00
31_P53_Y1.0761.00
87_L108_L1.0661.00
90_L119_N1.0541.00
86_D89_N1.0471.00
99_I123_C1.0471.00
44_N100_L1.0451.00
95_Q125_K1.0431.00
46_L75_E1.0081.00
46_L50_A1.0061.00
107_F134_A0.9991.00
116_L120_M0.9861.00
41_N64_S0.9721.00
92_F123_C0.9621.00
158_R161_E0.9521.00
102_T133_V0.9401.00
103_V133_V0.9381.00
66_A69_E0.9361.00
67_N71_I0.9291.00
72_K77_L0.9241.00
35_L99_I0.9211.00
48_L100_L0.9131.00
115_G119_N0.8991.00
105_L108_L0.8981.00
28_V32_G0.8961.00
13_Y16_T0.8921.00
21_E25_A0.8891.00
98_F129_Y0.8891.00
85_V90_L0.8761.00
57_A68_V0.8751.00
71_I74_I0.8661.00
38_G101_S0.8591.00
153_E170_E0.8541.00
41_N67_N0.8471.00
69_E73_S0.8461.00
44_N102_T0.8321.00
90_L123_C0.8321.00
34_T53_Y0.8311.00
69_E82_T0.8301.00
66_A70_R0.8291.00
145_V148_P0.8291.00
32_G97_D0.8111.00
39_C59_D0.8101.00
49_A79_N0.8061.00
56_D92_F0.8051.00
45_S80_L0.8041.00
45_S82_T0.8021.00
25_A169_N0.7981.00
165_R168_Y0.7901.00
155_E158_R0.7821.00
71_I75_E0.7801.00
50_A77_L0.7781.00
39_C65_I0.7661.00
105_L117_I0.7651.00
89_N115_G0.7621.00
106_M135_A0.7601.00
96_Y123_C0.7601.00
103_V135_A0.7511.00
34_T100_L0.7441.00
104_V107_F0.7441.00
42_G68_V0.7431.00
34_T55_V0.7281.00
23_L51_N0.7281.00
15_L19_H0.7271.00
93_D123_C0.7191.00
44_N47_Y0.7131.00
43_R47_Y0.7111.00
157_R168_Y0.7081.00
137_D152_K0.7061.00
35_L123_C0.7001.00
153_E157_R0.6891.00
46_L49_A0.6841.00
70_R73_S0.6831.00
43_R71_I0.6791.00
63_M67_N0.6781.00
23_L26_V0.6781.00
20_S47_Y0.6771.00
154_G157_R0.6761.00
92_F95_Q0.6731.00
121_Q162_G0.6691.00
37_L58_W0.6671.00
25_A167_K0.6651.00
41_N71_I0.6621.00
102_T106_M0.6581.00
118_A122_R0.6581.00
44_N106_M0.6531.00
88_N116_L0.6521.00
70_R74_I0.6501.00
21_E169_N0.6481.00
37_L99_I0.6461.00
73_S78_D0.6451.00
88_N108_L0.6401.00
95_Q123_C0.6391.00
58_W90_L0.6361.00
105_L116_L0.6351.00
46_L82_T0.6311.00
31_P52_G0.6291.00
60_K87_L0.6291.00
64_S103_V0.6251.00
33_K94_R0.6241.00
17_R20_S0.6211.00
101_S132_I0.6121.00
34_T52_G0.6101.00
35_L58_W0.6041.00
154_G158_R0.6021.00
15_L18_T0.6011.00
33_K53_Y0.6011.00
39_C82_T0.5901.00
105_L132_I0.5891.00
49_A77_L0.5881.00
46_L77_L0.5881.00
62_A69_E0.5871.00
88_N115_G0.5851.00
22_V131_L0.5841.00
46_L68_V0.5841.00
120_M124_T0.5831.00
44_N48_L0.5791.00
16_T20_S0.5781.00
77_L80_L0.5741.00
20_S24_E0.5731.00
130_N163_W0.5661.00
36_D107_F0.5651.00
101_S108_L0.5651.00
140_D143_C0.5621.00
122_R125_K0.5591.00
136_M170_E0.5541.00
101_S106_M0.5541.00
101_S120_M0.5471.00
155_E159_Y0.5471.00
135_A148_P0.5451.00
58_W83_R0.5451.00
64_S106_M0.5411.00
36_D57_A0.5391.00
30_K52_G0.5381.00
130_N160_Y0.5341.00
132_I160_Y0.5341.00
25_A28_V0.5321.00
156_L160_Y0.5311.00
102_T107_F0.5301.00
134_A156_L0.5291.00
69_E81_H0.5281.00
98_F128_G0.5281.00
129_Y166_V0.5261.00
117_I159_Y0.5241.00
42_G82_T0.5231.00
101_S116_L0.5221.00
38_G60_K0.5201.00
69_E72_K0.5191.00
60_K84_V0.5161.00
88_N110_A0.5151.00
59_D84_V0.5111.00
36_D44_N0.5071.00
146_G149_F0.5061.00
73_S76_N0.5041.00
25_A29_V0.5041.00
103_V134_A0.5031.00
89_N119_N0.5021.00
36_D55_V0.5021.00
45_S49_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2xvmA 1 1 100 0.329 Contact Map
3m70A 1 0.9949 100 0.346 Contact Map
2gb4A 1 0.9848 100 0.396 Contact Map
4kdcA 1 0.9442 100 0.4 Contact Map
4necA 3 0.9949 100 0.405 Contact Map
1y8cA 1 0.9645 100 0.405 Contact Map
2kw5A 1 0.9645 100 0.405 Contact Map
4kdrA 1 0.9492 100 0.415 Contact Map
3ccfA 1 0.9137 99.9 0.417 Contact Map
1wznA 4 0.9391 99.9 0.421 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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