GREMLIN Database
PTRB - Protease 2
UniProt: P24555 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11004
Length: 686 (635)
Sequences: 4297 (3220)
Seq/√Len: 127.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
586_P590_E4.3271.00
542_I552_V4.0961.00
424_R510_D4.0621.00
513_D545_R3.8671.00
422_V428_E3.8611.00
410_Y413_N3.6981.00
513_D548_L3.6251.00
531_G555_Q3.4681.00
159_N162_T3.4161.00
417_E435_Y3.3211.00
139_T161_E3.2321.00
502_K544_Q3.1341.00
59_D63_K3.0761.00
431_V511_A3.0631.00
514_A518_L3.0261.00
158_R165_W2.8861.00
611_V629_V2.7931.00
585_D588_Y2.7611.00
538_M552_V2.7601.00
512_C549_F2.6661.00
231_T238_V2.5841.00
522_S525_L2.5611.00
445_N476_V2.5471.00
281_R297_R2.5441.00
215_L218_E2.5401.00
433_L478_A2.4761.00
185_I188_Y2.4741.00
550_H608_H2.4731.00
449_V512_C2.4711.00
38_D42_Q2.4571.00
631_K635_L2.4361.00
112_E163_G2.4161.00
528_A552_V2.3691.00
387_T400_V2.3371.00
377_Y398_R2.3291.00
421_I431_V2.2941.00
527_Y672_L2.2841.00
202_W215_L2.2541.00
62_L66_I2.2521.00
421_I511_A2.2461.00
392_D395_T2.2381.00
221_D224_Y2.2181.00
542_I609_L2.1921.00
43_E633_R2.1731.00
415_R438_K2.1601.00
506_N544_Q2.1501.00
86_R99_Q2.1101.00
188_Y191_K2.1001.00
297_R307_E2.0961.00
157_F186_F2.0901.00
447_L526_C2.0851.00
159_N164_N2.0801.00
137_D183_S2.0701.00
512_C526_C2.0701.00
297_R309_L2.0671.00
417_E441_R2.0491.00
253_D256_M2.0381.00
187_Y191_K2.0201.00
499_L588_Y2.0031.00
495_D500_K1.9951.00
439_H445_N1.9931.00
381_S384_T1.9891.00
88_I111_W1.9891.00
54_Q58_Q1.9651.00
420_W428_E1.9641.00
502_K506_N1.9631.00
553_I672_L1.9631.00
295_L318_L1.9581.00
498_F588_Y1.9451.00
85_Y100_R1.9441.00
448_L529_M1.9431.00
424_R506_N1.9351.00
513_D517_K1.9231.00
204_H213_D1.9171.00
204_H207_G1.9021.00
38_D41_Q1.9011.00
205_A208_T1.8851.00
294_G308_E1.8811.00
37_L41_Q1.8651.00
28_D33_Q1.8641.00
34_P38_D1.8361.00
252_L259_A1.8351.00
97_I113_T1.8251.00
601_V628_W1.8241.00
450_Y459_I1.8021.00
448_L672_L1.7851.00
389_F400_V1.7751.00
611_V628_W1.7711.00
344_N347_T1.7681.00
168_E173_V1.7261.00
373_A394_D1.7241.00
421_I480_V1.7211.00
527_Y551_G1.7181.00
48_H52_A1.7091.00
310_I330_V1.6961.00
374_R390_E1.6941.00
169_L173_V1.6851.00
90_E93_C1.6771.00
516_L521_G1.6601.00
100_R112_E1.6561.00
449_V549_F1.6491.00
528_A538_M1.6461.00
499_L591_Y1.6451.00
101_Q111_W1.6421.00
119_K122_A1.6411.00
263_V266_P1.6411.00
451_G508_Y1.6371.00
444_H522_S1.6371.00
508_Y528_A1.6231.00
588_Y591_Y1.6121.00
189_V192_H1.6121.00
521_G526_C1.6111.00
158_R163_G1.6061.00
447_L521_G1.6041.00
529_M555_Q1.6031.00
334_Q339_S1.5981.00
140_I157_F1.5981.00
502_K594_S1.5971.00
420_W488_L1.5941.00
636_K642_L1.5931.00
631_K634_E1.5851.00
83_Y100_R1.5831.00
514_A517_K1.5831.00
249_V253_D1.5781.00
431_V478_A1.5751.00
528_A541_A1.5721.00
86_R111_W1.5701.00
660_K663_E1.5701.00
296_Y308_E1.5691.00
382_M479_I1.5691.00
171_D174_E1.5681.00
524_S550_H1.5661.00
434_V471_L1.5641.00
423_A506_N1.5631.00
458_S487_E1.5571.00
284_L287_N1.5541.00
545_R548_L1.5541.00
543_N628_W1.5471.00
99_Q113_T1.5451.00
373_A392_D1.5361.00
382_M432_S1.5321.00
400_V403_Q1.5201.00
344_N348_R1.5191.00
41_Q45_S1.5151.00
601_V635_L1.4851.00
184_W205_A1.4801.00
151_R619_Q1.4771.00
177_F186_F1.4771.00
491_Q495_D1.4711.00
168_E174_E1.4671.00
480_V511_A1.4641.00
451_G537_L1.4631.00
351_I396_G1.4601.00
332_E341_R1.4561.00
22_N631_K1.4551.00
223_T226_V1.4541.00
435_Y439_H1.4531.00
308_E311_P1.4521.00
170_L173_V1.4511.00
330_V343_I1.4511.00
169_L174_E1.4451.00
415_R435_Y1.4441.00
180_A184_W1.4431.00
387_T403_Q1.4431.00
568_E584_Q1.4431.00
509_L545_R1.4381.00
180_A185_I1.4301.00
61_I65_I1.4251.00
204_H208_T1.4231.00
467_R477_Y1.4201.00
339_S352_G1.4181.00
494_E497_K1.4101.00
509_L549_F1.4101.00
436_H439_H1.4011.00
591_Y594_S1.3961.00
172_N175_P1.3921.00
142_A155_I1.3911.00
86_R101_Q1.3851.00
64_E472_D1.3841.00
299_R302_D1.3841.00
200_Q218_E1.3821.00
130_G144_A1.3801.00
589_Y593_K1.3761.00
187_Y192_H1.3681.00
204_H209_P1.3641.00
24_Y563_T1.3611.00
327_W342_Q1.3591.00
513_D547_E1.3571.00
329_V375_L1.3561.00
553_I668_E1.3551.00
577_F582_N1.3531.00
424_R513_D1.3521.00
482_V504_T1.3441.00
490_Q494_E1.3431.00
169_L172_N1.3351.00
87_H98_Y1.3341.00
182_D185_I1.3331.00
235_H255_E1.3231.00
188_Y192_H1.3171.00
415_R437_R1.3161.00
155_I177_F1.3061.00
221_D226_V1.3051.00
187_Y190_R1.3041.00
265_L268_R1.3041.00
29_D32_S1.3011.00
432_S481_H1.3001.00
84_R104_F1.2961.00
287_N293_F1.2941.00
240_H244_A1.2901.00
656_S664_G1.2881.00
645_C667_M1.2861.00
47_G51_M1.2841.00
402_K406_V1.2841.00
357_D360_Y1.2821.00
590_E594_S1.2811.00
277_H282_F1.2801.00
596_S599_D1.2741.00
538_M541_A1.2741.00
209_P212_Q1.2631.00
208_T212_Q1.2561.00
440_F444_H1.2561.00
342_Q351_I1.2551.00
238_V251_L1.2501.00
224_Y230_K1.2481.00
52_A55_Q1.2471.00
419_L514_A1.2471.00
184_W188_Y1.2351.00
168_E171_D1.2351.00
136_P183_S1.2311.00
203_R214_K1.2301.00
509_L541_A1.2281.00
223_T230_K1.2251.00
421_I514_A1.2251.00
577_F584_Q1.2140.99
539_G559_V1.2070.99
440_F443_G1.2040.99
226_V230_K1.2010.99
79_I84_R1.2010.99
449_V480_V1.2000.99
516_L526_C1.1990.99
45_S49_R1.1980.99
473_R673_V1.1900.99
231_T236_Y1.1870.99
666_A670_A1.1860.99
562_V592_M1.1860.99
509_L513_D1.1740.99
214_K217_Y1.1730.99
139_T159_N1.1690.99
551_G672_L1.1680.99
142_A177_F1.1670.99
116_D119_K1.1620.99
421_I427_V1.1560.99
134_I141_M1.1550.99
282_F286_S1.1540.99
424_R427_V1.1470.99
140_I159_N1.1460.99
224_Y227_S1.1430.99
302_D305_Q1.1430.99
64_E67_D1.1430.99
79_I82_G1.1400.99
419_L431_V1.1400.99
55_Q58_Q1.1360.99
374_R392_D1.1300.99
509_L544_Q1.1290.99
26_L36_V1.1270.99
390_E401_L1.1270.99
282_F287_N1.1250.99
24_Y27_R1.1210.99
222_D226_V1.1180.99
335_R488_L1.1150.99
264_F273_Y1.1130.99
102_S112_E1.1120.99
250_R253_D1.1060.99
510_D513_D1.1060.99
142_A179_W1.1060.99
195_T198_P1.1050.99
440_F445_N1.1050.99
53_S674_A1.0960.99
137_D140_I1.0960.99
516_L548_L1.0900.99
93_C97_I1.0870.99
200_Q215_L1.0870.99
647_D650_S1.0840.99
282_F288_R1.0830.99
554_A559_V1.0820.99
295_L321_F1.0820.99
43_E46_Y1.0810.99
554_A628_W1.0810.99
156_R165_W1.0800.99
447_L478_A1.0780.99
124_S128_S1.0770.99
559_V628_W1.0770.99
143_L165_W1.0770.99
269_K272_E1.0760.99
501_K504_T1.0730.99
497_K579_E1.0690.99
295_L310_I1.0680.99
168_E172_N1.0670.99
142_A145_E1.0660.99
105_S109_D1.0640.99
221_D230_K1.0620.99
283_Y286_S1.0580.99
503_N506_N1.0580.99
102_S105_S1.0480.98
143_L146_D1.0460.98
200_Q204_H1.0460.98
434_V479_I1.0460.98
70_P405_E1.0450.98
421_I510_D1.0450.98
213_D216_I1.0430.98
562_V589_Y1.0430.98
124_S147_F1.0390.98
560_D627_K1.0390.98
444_H525_L1.0370.98
85_Y160_L1.0350.98
281_R286_S1.0350.98
103_A109_D1.0300.98
185_I203_R1.0280.98
419_L433_L1.0260.98
326_D373_A1.0260.98
185_I190_R1.0250.98
175_P179_W1.0200.98
283_Y287_N1.0200.98
201_V204_H1.0200.98
568_E577_F1.0130.98
151_R618_S1.0110.98
93_C118_N1.0090.98
190_R200_Q1.0080.98
540_V544_Q1.0020.98
470_L475_F1.0000.98
505_F541_A1.0000.98
42_Q45_S0.9990.98
292_N315_N0.9980.98
225_Y228_L0.9950.98
33_Q36_V0.9930.98
48_H55_Q0.9920.98
496_G503_N0.9910.98
207_G213_D0.9910.98
250_R263_V0.9890.98
83_Y102_S0.9880.98
190_R202_W0.9870.98
329_V342_Q0.9810.98
81_N138_N0.9810.98
464_S467_R0.9800.98
435_Y441_R0.9790.98
28_D32_S0.9790.98
66_I71_Q0.9790.98
493_Y497_K0.9770.98
120_R145_E0.9760.97
50_V53_S0.9730.97
83_Y112_E0.9700.97
251_L264_F0.9670.97
290_G294_G0.9610.97
82_G138_N0.9600.97
458_S486_G0.9600.97
281_R299_R0.9570.97
59_D62_L0.9560.97
63_K67_D0.9550.97
598_Y631_K0.9540.97
196_L199_Y0.9490.97
341_R352_G0.9490.97
554_A611_V0.9490.97
502_K591_Y0.9480.97
402_K405_E0.9460.97
187_Y216_I0.9420.97
476_V520_Y0.9420.97
141_M145_E0.9420.97
141_M160_L0.9400.97
270_D273_Y0.9380.97
643_L671_F0.9380.97
156_R167_P0.9340.97
72_R91_P0.9340.97
512_C521_G0.9340.97
475_F673_V0.9340.97
552_V609_L0.9290.97
142_A146_D0.9250.97
378_G386_D0.9240.97
55_Q59_D0.9230.96
447_L476_V0.9200.96
478_A515_L0.9190.96
529_M553_I0.9190.96
330_V341_R0.9150.96
208_T213_D0.9140.96
403_Q406_V0.9130.96
454_S533_A0.9120.96
286_S296_Y0.9110.96
435_Y476_V0.9100.96
213_D217_Y0.9090.96
603_A635_L0.9090.96
449_V526_C0.9090.96
333_R460_D0.9070.96
185_I191_K0.9060.96
99_Q111_W0.9040.96
508_Y537_L0.9000.96
98_Y117_A0.9000.96
564_T576_E0.9000.96
199_Y218_E0.8990.96
529_M668_E0.8980.96
298_T306_W0.8980.96
64_E68_R0.8960.96
555_Q612_T0.8940.96
280_H299_R0.8940.96
140_I144_A0.8900.96
267_R273_Y0.8900.96
419_L518_L0.8840.96
34_P37_L0.8840.96
269_K273_Y0.8830.95
21_D598_Y0.8820.95
180_A183_S0.8800.95
90_E97_I0.8790.95
431_V514_A0.8790.95
49_R52_A0.8750.95
506_N510_D0.8720.95
224_Y231_T0.8720.95
101_Q105_S0.8680.95
136_P179_W0.8680.95
538_M554_A0.8670.95
400_V406_V0.8660.95
647_D663_E0.8640.95
143_L156_R0.8590.95
127_Y145_E0.8580.95
449_V478_A0.8570.95
140_I183_S0.8560.95
283_Y309_L0.8550.95
355_F360_Y0.8550.95
87_H96_A0.8550.95
196_L201_V0.8550.95
295_L309_L0.8550.95
180_A203_R0.8550.95
66_I70_P0.8540.95
267_R272_E0.8510.94
605_A637_T0.8500.94
252_L261_P0.8490.94
185_I205_A0.8470.94
40_L626_A0.8450.94
185_I189_V0.8430.94
186_F191_K0.8430.94
235_H253_D0.8420.94
222_D228_L0.8420.94
291_K294_G0.8390.94
483_R507_D0.8390.94
439_H520_Y0.8390.94
573_T576_E0.8370.94
416_S434_V0.8350.94
199_Y204_H0.8350.94
141_M144_A0.8350.94
423_A427_V0.8330.94
142_A147_F0.8320.94
626_A646_T0.8320.94
562_V593_K0.8320.94
64_E473_R0.8300.94
505_F540_V0.8300.94
611_V632_L0.8270.94
610_L643_L0.8270.94
268_R273_Y0.8260.94
170_L174_E0.8230.93
467_R471_L0.8220.93
498_F591_Y0.8190.93
279_Q283_Y0.8190.93
315_N334_Q0.8160.93
454_S504_T0.8130.93
359_A362_T0.8130.93
576_E580_W0.8120.93
376_R390_E0.8110.93
531_G556_V0.8110.93
341_R350_V0.8100.93
482_V508_Y0.8090.93
638_D642_L0.8090.93
496_G504_T0.8080.93
467_R669_Y0.8050.93
225_Y230_K0.8020.93
390_E399_R0.8000.92
227_S230_K0.7990.92
239_I261_P0.7990.92
423_A510_D0.7980.92
224_Y228_L0.7970.92
140_I145_E0.7970.92
441_R445_N0.7960.92
323_L345_R0.7930.92
255_E259_A0.7930.92
247_S250_R0.7930.92
637_T642_L0.7930.92
65_I69_I0.7920.92
531_G653_G0.7910.92
48_H58_Q0.7910.92
602_T606_Y0.7890.92
187_Y230_K0.7890.92
441_R444_H0.7880.92
414_Y472_D0.7840.92
97_I118_N0.7840.92
392_D397_E0.7830.92
433_L476_V0.7820.92
205_A214_K0.7820.92
265_L271_H0.7790.91
662_Y666_A0.7760.91
317_M486_G0.7750.91
199_Y202_W0.7740.91
62_L663_E0.7730.91
516_L523_P0.7730.91
557_P625_P0.7730.91
65_I466_S0.7720.91
281_R287_N0.7710.91
35_E38_D0.7690.91
45_S48_H0.7690.91
253_D259_A0.7690.91
604_Q637_T0.7690.91
256_M259_A0.7680.91
505_F595_Y0.7680.91
79_I103_A0.7680.91
197_L201_V0.7680.91
241_L244_A0.7650.91
280_H284_L0.7650.91
539_G554_A0.7640.91
174_E179_W0.7620.91
666_A671_F0.7590.90
88_I99_Q0.7590.90
293_F297_R0.7580.90
141_M147_F0.7570.90
61_I473_R0.7550.90
255_E258_D0.7550.90
356_D360_Y0.7530.90
663_E667_M0.7520.90
357_D361_V0.7500.90
525_L550_H0.7500.90
650_S660_K0.7500.90
643_L647_D0.7490.90
51_M54_Q0.7490.90
115_L120_R0.7480.90
413_N436_H0.7480.90
264_F275_L0.7480.90
71_Q92_G0.7470.90
178_V228_L0.7470.90
613_T646_T0.7450.90
572_L575_G0.7450.90
206_I209_P0.7420.89
120_R127_Y0.7410.89
267_R271_H0.7410.89
222_D230_K0.7400.89
265_L270_D0.7380.89
555_Q668_E0.7350.89
484_G507_D0.7340.89
583_P592_M0.7320.89
522_S550_H0.7300.89
237_V254_A0.7300.89
39_Y634_E0.7290.89
248_E267_R0.7280.88
601_V604_Q0.7270.88
541_A549_F0.7270.88
568_E583_P0.7260.88
356_D398_R0.7230.88
245_T578_E0.7230.88
105_S110_E0.7230.88
292_N295_L0.7220.88
478_A511_A0.7200.88
600_N603_A0.7190.88
383_T416_S0.7170.88
201_V207_G0.7160.88
294_G312_P0.7150.88
591_Y595_Y0.7150.88
551_G607_P0.7130.87
168_E175_P0.7120.87
613_T622_Y0.7110.87
226_V231_T0.7110.87
353_I359_A0.7100.87
70_P73_E0.7080.87
283_Y297_R0.7060.87
264_F267_R0.7040.87
569_S584_Q0.7030.87
74_V77_P0.7030.87
280_H286_S0.7020.87
409_F414_Y0.7010.87
202_W214_K0.7010.87
556_V653_G0.7000.86
213_D218_E0.6960.86
104_F109_D0.6960.86
82_G102_S0.6950.86
252_L260_E0.6940.86
61_I64_E0.6940.86
284_L288_R0.6940.86
185_I192_H0.6940.86
425_D483_R0.6920.86
270_D274_S0.6910.86
267_R270_D0.6910.86
226_V239_I0.6910.86
538_M542_I0.6900.86
598_Y627_K0.6900.86
46_Y50_V0.6890.86
354_A357_D0.6890.86
33_Q38_D0.6870.85
60_R63_K0.6860.85
331_E338_T0.6860.85
51_M58_Q0.6860.85
94_E660_K0.6860.85
246_T270_D0.6850.85
34_P41_Q0.6850.85
49_R53_S0.6840.85
351_I391_L0.6810.85
543_N600_N0.6810.85
380_S386_D0.6800.85
140_I146_D0.6790.85
452_Y532_S0.6780.85
324_F329_V0.6780.85
439_H444_H0.6770.85
642_L645_C0.6760.84
516_L522_S0.6740.84
101_Q109_D0.6700.84
303_E306_W0.6700.84
162_T165_W0.6690.84
27_R563_T0.6680.84
442_K445_N0.6680.84
120_R158_R0.6660.84
277_H280_H0.6660.84
449_V508_Y0.6660.84
645_C648_M0.6650.84
422_V429_V0.6650.84
391_L396_G0.6640.83
561_V576_E0.6640.83
141_M146_D0.6620.83
143_L147_F0.6610.83
201_V217_Y0.6600.83
183_S187_Y0.6590.83
174_E178_V0.6580.83
197_L202_W0.6580.83
134_I160_L0.6580.83
554_A625_P0.6580.83
140_I206_I0.6570.83
137_D182_D0.6570.83
22_N634_E0.6570.83
436_H472_D0.6560.83
563_T627_K0.6540.82
329_V393_M0.6530.82
554_A609_L0.6530.82
313_R316_I0.6520.82
146_D151_R0.6510.82
268_R272_E0.6510.82
186_F190_R0.6510.82
265_L303_E0.6490.82
561_V596_S0.6490.82
280_H301_R0.6480.82
509_L547_E0.6480.82
268_R271_H0.6470.82
575_G578_E0.6470.82
280_H287_N0.6460.82
554_A601_V0.6460.82
320_G331_E0.6460.82
556_V651_G0.6450.82
252_L256_M0.6440.82
328_L345_R0.6440.82
73_E76_A0.6440.82
439_H442_K0.6430.81
65_I662_Y0.6430.81
601_V631_K0.6420.81
217_Y250_R0.6410.81
195_T199_Y0.6410.81
174_E177_F0.6390.81
499_L502_K0.6360.81
205_A258_D0.6360.81
184_W203_R0.6360.81
282_F300_M0.6350.81
435_Y445_N0.6350.81
536_M597_P0.6350.81
58_Q667_M0.6340.81
296_Y299_R0.6340.81
501_K536_M0.6340.81
313_R334_Q0.6330.80
561_V564_T0.6330.80
205_A209_P0.6320.80
624_E627_K0.6320.80
262_F265_L0.6310.80
558_F561_V0.6300.80
527_Y550_H0.6300.80
286_S294_G0.6260.80
391_L398_R0.6250.80
112_E161_E0.6240.79
169_L175_P0.6230.79
321_F324_F0.6220.79
511_A514_A0.6210.79
120_R143_L0.6200.79
540_V595_Y0.6200.79
482_V541_A0.6200.79
609_L642_L0.6190.79
670_A674_A0.6190.79
422_V518_L0.6190.79
418_H432_S0.6180.79
597_P607_P0.6170.79
117_A129_M0.6170.79
403_Q411_A0.6150.78
125_E128_S0.6150.78
388_L401_L0.6150.78
430_P492_W0.6140.78
117_A127_Y0.6140.78
93_C122_A0.6140.78
564_T577_F0.6130.78
223_T228_L0.6120.78
84_R101_Q0.6120.78
293_F296_Y0.6120.78
104_F110_E0.6110.78
115_L141_M0.6110.78
251_L254_A0.6100.78
433_L520_Y0.6100.78
564_T621_Q0.6100.78
144_A177_F0.6090.78
427_V506_N0.6090.78
609_L632_L0.6080.78
318_L324_F0.6080.78
500_K561_V0.6070.78
438_K441_R0.6050.77
298_T304_Q0.6050.77
264_F269_K0.6030.77
456_G486_G0.6030.77
318_L321_F0.6030.77
321_F330_V0.6030.77
298_T303_E0.6030.77
40_L44_N0.6020.77
70_P89_Y0.6020.77
553_I612_T0.6010.77
533_A536_M0.6010.77
622_Y626_A0.6010.77
132_M141_M0.6000.77
313_R332_E0.5980.77
181_N255_E0.5980.77
413_N437_R0.5980.77
251_L282_F0.5970.76
411_A414_Y0.5970.76
247_S251_L0.5960.76
187_Y203_R0.5950.76
41_Q648_M0.5950.76
556_V619_Q0.5950.76
542_I604_Q0.5940.76
338_T361_V0.5940.76
490_Q493_Y0.5920.76
419_L478_A0.5910.76
222_D229_H0.5910.76
37_L615_L0.5900.76
429_V492_W0.5890.75
213_D219_E0.5880.75
355_F358_P0.5860.75
127_Y147_F0.5860.75
451_G459_I0.5850.75
469_S669_Y0.5850.75
144_A147_F0.5830.75
84_R103_A0.5830.75
661_S664_G0.5830.75
197_L204_H0.5830.75
459_I482_V0.5830.75
249_V252_L0.5820.75
264_F270_D0.5820.75
278_Y287_N0.5810.74
285_R288_R0.5800.74
278_Y285_R0.5790.74
124_S129_M0.5790.74
563_T624_E0.5790.74
248_E266_P0.5790.74
448_L470_L0.5780.74
210_A215_L0.5780.74
243_S246_T0.5780.74
553_I610_L0.5780.74
157_F166_Y0.5780.74
191_K196_L0.5780.74
295_L298_T0.5770.74
582_N585_D0.5770.74
229_H232_T0.5770.74
278_Y283_Y0.5760.74
629_V642_L0.5760.74
573_T580_W0.5760.74
554_A557_P0.5750.74
29_D36_V0.5750.74
184_W190_R0.5730.73
68_R469_S0.5730.73
409_F413_N0.5730.73
613_T618_S0.5730.73
613_T625_P0.5730.73
181_N184_W0.5730.73
69_I73_E0.5720.73
124_S130_G0.5720.73
33_Q37_L0.5720.73
253_D257_A0.5710.73
197_L206_I0.5710.73
222_D225_Y0.5700.73
526_C548_L0.5700.73
422_V514_A0.5690.73
278_Y281_R0.5680.73
539_G543_N0.5680.73
500_K503_N0.5670.73
247_S254_A0.5670.73
436_H445_N0.5670.73
448_L527_Y0.5660.73
605_A638_D0.5660.73
188_Y194_V0.5650.72
170_L175_P0.5640.72
281_R285_R0.5640.72
134_I138_N0.5640.72
453_G507_D0.5640.72
564_T624_E0.5620.72
140_I166_Y0.5620.72
642_L646_T0.5610.72
159_N166_Y0.5610.72
58_Q663_E0.5590.72
399_R406_V0.5590.72
269_K274_S0.5590.72
101_Q110_E0.5590.72
96_A117_A0.5590.72
292_N296_Y0.5570.71
222_D232_T0.5560.71
459_I479_I0.5560.71
28_D36_V0.5540.71
499_L587_Q0.5540.71
98_Y132_M0.5540.71
231_T275_L0.5530.71
200_Q206_I0.5520.71
497_K500_K0.5520.71
453_G485_G0.5520.71
60_R64_E0.5520.71
73_E92_G0.5510.71
667_M671_F0.5510.71
67_D408_G0.5510.71
442_K525_L0.5500.70
377_Y391_L0.5500.70
145_E156_R0.5490.70
124_S127_Y0.5490.70
235_H244_A0.5480.70
239_I244_A0.5480.70
60_R122_A0.5470.70
289_H294_G0.5470.70
278_Y284_L0.5470.70
205_A212_Q0.5470.70
191_K194_V0.5470.70
327_W344_N0.5460.70
442_K522_S0.5460.70
239_I243_S0.5450.70
231_T235_H0.5440.70
417_E518_L0.5440.70
439_H476_V0.5440.70
135_T183_S0.5430.69
335_R420_W0.5430.69
178_V230_K0.5420.69
418_H421_I0.5420.69
51_M643_L0.5410.69
481_H485_G0.5410.69
61_I67_D0.5400.69
516_L519_G0.5400.69
233_S277_H0.5390.69
63_K66_I0.5380.69
196_L200_Q0.5380.69
401_L404_T0.5380.69
250_R261_P0.5370.69
275_L280_H0.5370.69
264_F272_E0.5370.69
59_D663_E0.5370.69
163_G166_Y0.5360.68
202_W206_I0.5360.68
336_G432_S0.5360.68
453_G484_G0.5360.68
32_S37_L0.5350.68
457_A531_G0.5340.68
397_E400_V0.5340.68
625_P644_L0.5340.68
355_F362_T0.5340.68
560_D595_Y0.5330.68
290_G296_Y0.5330.68
643_L646_T0.5320.68
456_G579_E0.5310.68
87_H132_M0.5310.68
69_I75_S0.5310.68
288_R303_E0.5310.68
61_I69_I0.5300.68
358_P417_E0.5300.68
318_L330_V0.5300.68
265_L273_Y0.5300.68
455_Y580_W0.5290.67
221_D231_T0.5290.67
34_P49_R0.5280.67
570_I621_Q0.5280.67
202_W213_D0.5270.67
614_G621_Q0.5270.67
151_R613_T0.5270.67
665_V668_E0.5270.67
558_F572_L0.5260.67
276_D285_R0.5250.67
217_Y226_V0.5250.67
661_S665_V0.5250.67
131_G144_A0.5250.67
176_S179_W0.5240.67
367_N370_P0.5240.67
144_A186_F0.5230.67
252_L257_A0.5230.67
148_L649_D0.5230.67
215_L219_E0.5230.67
239_I245_T0.5230.67
571_P623_W0.5230.67
508_Y538_M0.5230.67
205_A213_D0.5220.66
627_K630_A0.5220.66
188_Y213_D0.5220.66
622_Y646_T0.5220.66
482_V537_L0.5220.66
288_R294_G0.5210.66
539_G557_P0.5200.66
68_R74_V0.5200.66
268_R274_S0.5180.66
93_C117_A0.5180.66
231_T234_K0.5180.66
88_I97_I0.5180.66
140_I143_L0.5170.66
467_R529_M0.5160.66
38_D603_A0.5160.66
353_I360_Y0.5150.65
240_H249_V0.5150.65
542_I606_Y0.5150.65
276_D279_Q0.5150.65
450_Y529_M0.5150.65
196_L204_H0.5140.65
82_G103_A0.5140.65
26_L39_Y0.5140.65
427_V488_L0.5140.65
252_L255_E0.5120.65
504_T533_A0.5120.65
254_A257_A0.5110.65
155_I210_A0.5110.65
569_S619_Q0.5110.65
657_G660_K0.5100.65
39_Y626_A0.5100.65
336_G418_H0.5100.65
276_D286_S0.5090.65
47_G643_L0.5090.65
617_D620_V0.5080.64
561_V595_Y0.5080.64
147_F154_G0.5080.64
189_V228_L0.5080.64
90_E99_Q0.5070.64
206_I212_Q0.5070.64
78_Y87_H0.5060.64
67_D74_V0.5060.64
226_V229_H0.5060.64
481_H488_L0.5050.64
573_T579_E0.5050.64
142_A186_F0.5050.64
582_N588_Y0.5050.64
533_A537_L0.5040.64
224_Y229_H0.5030.64
435_Y520_Y0.5030.64
576_E579_E0.5030.64
64_E69_I0.5020.63
225_Y575_G0.5020.63
254_A258_D0.5020.63
278_Y286_S0.5020.63
531_G619_Q0.5010.63
404_T407_P0.5010.63
564_T571_P0.5000.63
536_M540_V0.5000.63
187_Y194_V0.5000.63
351_I354_A0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4bp8A 1 0.9869 100 0.242 Contact Map
2xe4A 1 0.9956 100 0.244 Contact Map
3iujA 1 0.9621 100 0.273 Contact Map
1yr2A 1 0.9636 100 0.277 Contact Map
2bklA 1 0.9665 100 0.289 Contact Map
2xdwA 2 0.9752 100 0.299 Contact Map
4hvtA 1 0.9417 100 0.378 Contact Map
3azoA 1 0.8936 100 0.496 Contact Map
2z3zA 2 0.8338 100 0.536 Contact Map
4hxfB 4 0.8222 100 0.538 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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