GREMLIN Database
CRL - Sigma factor-binding protein Crl
UniProt: P24251 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11092
Length: 133 (120)
Sequences: 154 (91)
Seq/√Len: 8.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
66_R116_L2.9210.87
60_L107_L2.7680.84
18_A111_L2.2810.70
59_E109_E2.1360.65
64_E86_P2.1340.65
96_L123_D2.1160.64
18_A40_V2.0690.62
16_F114_L2.0610.62
67_F111_L2.0390.61
19_L69_Y2.0060.60
19_L34_F1.9790.59
65_S84_S1.9200.56
100_L120_P1.9040.55
49_E104_H1.8590.54
100_L118_L1.8340.53
23_I58_M1.7830.50
28_C50_V1.6750.46
11_R46_P1.6450.45
58_M116_L1.6360.44
52_E80_G1.6260.44
42_V75_L1.5520.41
11_R48_P1.5380.40
14_K88_K1.5300.40
13_I86_P1.5160.39
40_V61_E1.5000.39
102_E106_K1.4620.37
50_V90_T1.4570.37
23_I71_Y1.4540.37
8_P13_I1.4490.37
54_W99_T1.4440.37
71_Y104_H1.4410.36
81_D105_E1.4400.36
19_L98_H1.4390.36
96_L106_K1.4330.36
15_K98_H1.4120.35
64_E94_E1.4030.35
104_H124_F1.4030.35
4_P88_K1.4000.35
9_K106_K1.3600.33
61_E115_N1.3180.32
112_T115_N1.3000.31
9_K13_I1.2850.31
34_F69_Y1.2840.31
95_R98_H1.2780.30
43_N104_H1.2170.28
30_D90_T1.2160.28
12_L99_T1.2000.28
84_S90_T1.1870.27
73_F110_L1.1740.27
23_I31_N1.1730.27
44_V75_L1.1570.26
19_L101_R1.1420.26
13_I110_L1.1360.26
99_T102_E1.1220.25
14_K75_L1.1220.25
9_K33_F1.1210.25
68_T81_D1.1190.25
18_A98_H1.1170.25
67_F116_L1.1080.25
61_E68_T1.1000.24
17_T23_I1.0890.24
15_K110_L1.0350.22
70_S77_D1.0010.22
44_V121_A1.0000.21
65_S117_K0.9990.21
9_K28_C0.9980.21
96_L113_T0.9930.21
9_K88_K0.9930.21
76_F109_E0.9790.21
40_V75_L0.9700.21
16_F88_K0.9650.21
9_K12_L0.9580.20
59_E84_S0.9440.20
77_D119_E0.9420.20
6_G46_P0.9380.20
42_V76_F0.9280.20
45_K75_L0.9180.19
43_N115_N0.9100.19
88_K106_K0.9000.19
12_L37_C0.8790.18
78_K87_V0.8750.18
8_P69_Y0.8740.18
28_C97_E0.8730.18
121_A124_F0.8700.18
25_E28_C0.8650.18
50_V72_Q0.8600.18
10_S34_F0.8590.18
90_T122_D0.8550.18
72_Q116_L0.8470.17
5_S116_L0.8440.17
44_V100_L0.8410.17
8_P42_V0.8250.17
14_K106_K0.8210.17
25_E54_W0.8180.17
7_H10_S0.8170.17
39_A78_K0.8140.17
77_D122_D0.8090.17
26_G102_E0.8020.16
15_K73_F0.8000.16
33_F95_R0.7980.16
23_I54_W0.7870.16
45_K87_V0.7860.16
60_L77_D0.7820.16
87_V93_V0.7820.16
13_I114_L0.7800.16
6_G62_A0.7750.16
44_V124_F0.7710.16
44_V69_Y0.7660.16
85_V115_N0.7620.16
31_N87_V0.7480.15
58_M71_Y0.7470.15
58_M122_D0.7420.15
10_S68_T0.7410.15
9_K96_L0.7350.15
8_P33_F0.7320.15
14_K110_L0.7270.15
8_P73_F0.7200.15
91_E124_F0.7180.15
45_K109_E0.7160.15
60_L104_H0.7150.15
18_A89_D0.7120.14
105_E109_E0.7080.14
6_G68_T0.7040.14
43_N63_Q0.6980.14
63_Q68_T0.6980.14
7_H16_F0.6960.14
6_G9_K0.6890.14
88_K91_E0.6860.14
58_M102_E0.6850.14
47_A69_Y0.6850.14
108_R118_L0.6790.14
11_R32_R0.6790.14
33_F69_Y0.6740.14
34_F39_A0.6640.13
62_A73_F0.6620.13
34_F43_N0.6610.13
70_S105_E0.6580.13
75_L78_K0.6540.13
17_T69_Y0.6400.13
44_V95_R0.6330.13
30_D86_P0.6240.13
45_K98_H0.6230.13
19_L110_L0.6160.13
25_E40_V0.6090.12
9_K14_K0.6080.12
68_T79_A0.6060.12
63_Q113_T0.5970.12
19_L42_V0.5970.12
16_F60_L0.5930.12
33_F99_T0.5920.12
86_P122_D0.5910.12
27_K49_E0.5890.12
44_V120_P0.5880.12
65_S122_D0.5870.12
58_M72_Q0.5840.12
43_N91_E0.5820.12
72_Q75_L0.5750.12
68_T116_L0.5750.12
61_E122_D0.5710.12
13_I89_D0.5600.12
81_D109_E0.5540.11
63_Q122_D0.5520.11
37_C45_K0.5470.11
26_G124_F0.5450.11
58_M96_L0.5380.11
31_N96_L0.5330.11
13_I117_K0.5330.11
14_K19_L0.5320.11
34_F120_P0.5310.11
32_R84_S0.5290.11
8_P124_F0.5270.11
100_L114_L0.5220.11
63_Q109_E0.5220.11
7_H114_L0.5170.11
109_E113_T0.5140.11
73_F100_L0.5130.11
31_N109_E0.5120.11
61_E94_E0.5030.11
29_K112_T0.5020.11
59_E98_H0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rpjA 2 0.9549 100 0.027 Contact Map
3upsA 2 0.4737 20.1 0.954 Contact Map
2a1vA 1 0.797 19 0.954 Contact Map
3m62A 1 0.6692 9.9 0.96 Contact Map
4bgbA 1 0.7669 9 0.96 Contact Map
2vqpA 1 0.3609 7.9 0.961 Contact Map
2fkiA 1 0.6992 6.5 0.963 Contact Map
1fcqA 1 0.188 5.2 0.965 Contact Map
2p8eA 1 0.8045 5.1 0.965 Contact Map
3p6aA 1 0.3534 4.4 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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