ASCG - ECOLI - GREMLIN Contacts

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ASCG - HTH-type transcriptional regulator AscG

UniProt:	P24242	Sequences: MTTMLEVAKRAGVSKATVSRVLSGNGYVSQETKDRVFQAVEESGYRPNLLARNLSAKSTQTLGLVVTNTLYHGIYFSELLFHAARMAEEKGRQLLLADGKHSAEEERQAIQYLLDLRCDAIMIYPRFLSVDEIDDIIDAHSQPIMVLNRRLRKNSSHSVWCDHKQTSFNAVAELINAGHQEIAFLTGSMDSPTSIERLAGYKDALAQHGIALNEKLIANGKWTPASGAEGVEMLLERGAKFSALVASNDDMAIGAMKALHERGVAVPEQVSVIGFDDIAIAPYTVPALSSVKIPVTEMIQEIIGRLIFMLDGGDFSPPKTFSGKLIRRDSLIAPSR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10087
Length:	336 (325)
Sequences:	37130 (27025)
Seq/√Len:	1499.0

ECOLI - ASCG GALR GALS PURR CYTR RBSR CRA MALI LACI IDNR GNTR YCJW EBGR TRER TORT YTFQ ALSB RBSB XYLF LSRB YPHF ARAF DGAL XYLR
BACSU - RBSR KDGR NTDR CCPA MSMR DEGA EXUR YKVZ GANR YVDE ARAR CCPB RBSB

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
164_K	203_D	3.389	1.00
10_R	42_E	3.129	1.00
265_A	268_E	3.057	1.00
179_H	242_S	2.953	1.00
198_L	202_K	2.661	1.00
120_A	306_L	2.608	1.00
170_A	273_I	2.590	1.00
179_H	271_S	2.409	1.00
277_D	292_K	2.388	1.00
157_H	309_M	2.340	1.00
30_Q	34_D	2.302	1.00
168_F	207_Q	2.301	1.00
38_Q	42_E	2.263	1.00
228_A	261_E	2.234	1.00
232_E	262_R	2.186	1.00
86_M	89_E	2.183	1.00
34_D	38_Q	2.175	1.00
86_M	304_G	2.167	1.00
172_A	204_A	2.131	1.00
168_F	204_A	2.121	1.00
232_E	258_A	2.113	1.00
165_Q	169_N	2.105	1.00
175_I	208_H	2.076	1.00
168_F	203_D	2.068	1.00
301_E	304_G	2.027	1.00
21_V	36_V	1.996	1.00
87_A	303_I	1.967	1.00
86_M	300_Q	1.955	1.00
164_K	199_A	1.931	1.00
33_K	37_F	1.923	1.00
5_L	15_K	1.884	1.00
174_L	243_A	1.878	1.00
22_L	40_V	1.869	1.00
166_T	275_F	1.862	1.00
167_S	171_V	1.822	1.00
172_A	176_N	1.820	1.00
10_R	39_A	1.816	1.00
177_A	331_L	1.814	1.00
259_L	270_V	1.811	1.00
292_K	324_K	1.797	1.00
82_H	299_I	1.795	1.00
167_S	245_V	1.782	1.00
308_F	313_G	1.780	1.00
171_V	201_Y	1.779	1.00
236_E	262_R	1.776	1.00
172_A	208_H	1.772	1.00
85_R	296_T	1.747	1.00
168_F	172_A	1.725	1.00
11_A	39_A	1.720	1.00
228_A	258_A	1.717	1.00
181_E	213_N	1.711	1.00
183_A	241_F	1.704	1.00
264_V	269_Q	1.689	1.00
227_G	254_G	1.684	1.00
231_V	255_A	1.661	1.00
246_A	255_A	1.649	1.00
63_G	118_C	1.642	1.00
294_P	297_E	1.639	1.00
82_H	296_T	1.638	1.00
86_M	90_K	1.634	1.00
258_A	262_R	1.630	1.00
184_F	247_S	1.624	1.00
260_H	285_V	1.612	1.00
147_L	302_I	1.609	1.00
169_N	323_G	1.608	1.00
265_A	269_Q	1.590	1.00
287_A	329_D	1.574	1.00
173_E	177_A	1.571	1.00
173_E	176_N	1.571	1.00
218_A	233_M	1.564	1.00
37_F	41_E	1.559	1.00
165_Q	168_F	1.544	1.00
181_E	240_K	1.542	1.00
90_K	307_I	1.541	1.00
175_I	204_A	1.521	1.00
258_A	261_E	1.517	1.00
199_A	203_D	1.499	1.00
297_E	301_E	1.493	1.00
173_E	327_R	1.468	1.00
307_I	311_D	1.461	1.00
162_D	165_Q	1.447	1.00
202_K	206_A	1.446	1.00
37_F	40_V	1.444	1.00
7_V	39_A	1.443	1.00
21_V	40_V	1.426	1.00
60_Q	119_D	1.420	1.00
196_E	199_A	1.416	1.00
204_A	207_Q	1.413	1.00
297_E	300_Q	1.385	1.00
181_E	242_S	1.370	1.00
228_A	257_K	1.367	1.00
10_R	43_S	1.367	1.00
259_L	264_V	1.363	1.00
86_M	303_I	1.354	1.00
277_D	328_R	1.350	1.00
228_A	232_E	1.348	1.00
166_T	323_G	1.337	1.00
232_E	261_E	1.328	1.00
5_L	9_K	1.307	1.00
171_V	175_I	1.302	1.00
60_Q	92_R	1.301	1.00
35_R	39_A	1.300	1.00
231_V	244_L	1.292	1.00
30_Q	33_K	1.291	1.00
183_A	234_L	1.290	1.00
39_A	42_E	1.286	1.00
171_V	204_A	1.272	1.00
122_M	302_I	1.271	1.00
164_K	168_F	1.264	1.00
6_E	9_K	1.261	1.00
232_E	236_E	1.261	1.00
62_L	87_A	1.257	1.00
169_N	172_A	1.249	1.00
304_G	308_F	1.247	1.00
20_R	25_N	1.233	1.00
29_S	32_T	1.232	1.00
173_E	331_L	1.231	1.00
171_V	200_G	1.225	1.00
213_N	216_L	1.220	1.00
231_V	259_L	1.218	1.00
97_A	109_A	1.215	1.00
87_A	94_L	1.214	1.00
167_S	200_G	1.213	1.00
200_G	204_A	1.211	1.00
39_A	43_S	1.203	1.00
256_M	272_V	1.203	1.00
63_G	113_L	1.201	1.00
32_T	35_R	1.193	1.00
172_A	207_Q	1.189	1.00
233_M	237_R	1.183	1.00
296_T	300_Q	1.177	1.00
164_K	196_E	1.172	1.00
221_K	226_S	1.169	1.00
83_A	303_I	1.166	1.00
201_Y	205_L	1.165	1.00
204_A	208_H	1.159	1.00
21_V	28_V	1.152	1.00
7_V	43_S	1.150	1.00
7_V	11_A	1.146	1.00
230_G	233_M	1.144	1.00
4_M	15_K	1.143	1.00
97_A	113_L	1.141	1.00
61_T	93_Q	1.139	1.00
64_L	83_A	1.135	1.00
90_K	304_G	1.118	1.00
34_D	37_F	1.113	1.00
164_K	200_G	1.108	1.00
61_T	95_L	1.107	1.00
184_F	198_L	1.106	1.00
179_H	243_A	1.104	1.00
225_A	229_E	1.101	1.00
273_I	289_S	1.100	1.00
301_E	305_R	1.094	1.00
83_A	122_M	1.089	1.00
170_A	245_V	1.082	1.00
271_S	331_L	1.081	1.00
223_T	226_S	1.081	1.00
84_A	88_E	1.080	1.00
38_Q	41_E	1.078	1.00
24_G	33_K	1.076	1.00
185_L	255_A	1.073	1.00
254_G	258_A	1.071	1.00
203_D	207_Q	1.071	1.00
182_I	205_L	1.066	1.00
181_E	239_A	1.063	1.00
244_L	255_A	1.063	1.00
299_I	303_I	1.060	1.00
218_A	230_G	1.049	1.00
4_M	18_V	1.047	1.00
199_A	202_K	1.045	1.00
195_I	199_A	1.037	1.00
180_Q	242_S	1.032	1.00
175_I	210_I	1.029	1.00
205_L	210_I	1.028	1.00
107_R	111_Q	1.025	1.00
238_G	241_F	1.025	1.00
64_L	94_L	1.024	1.00
189_M	219_N	1.023	1.00
92_R	307_I	1.023	1.00
301_E	321_F	1.016	1.00
177_A	327_R	1.009	1.00
48_N	54_L	1.009	1.00
300_Q	304_G	1.005	1.00
157_H	305_R	1.002	1.00
246_A	251_M	1.001	1.00
177_A	271_S	0.999	1.00
50_L	53_N	0.996	1.00
88_E	105_E	0.994	1.00
292_K	326_I	0.992	1.00
201_Y	245_V	0.990	1.00
226_S	229_E	0.988	1.00
90_K	311_D	0.988	1.00
105_E	108_Q	0.987	1.00
176_N	208_H	0.986	1.00
229_E	233_M	0.986	1.00
249_D	290_S	0.980	1.00
246_A	252_A	0.975	1.00
182_I	243_A	0.974	1.00
40_V	43_S	0.971	1.00
165_Q	322_S	0.969	1.00
260_H	287_A	0.969	1.00
249_D	274_G	0.968	1.00
306_L	310_L	0.954	1.00
224_P	257_K	0.951	1.00
256_M	266_V	0.948	1.00
256_M	284_T	0.946	1.00
294_P	324_K	0.946	1.00
81_F	85_R	0.945	1.00
227_G	231_V	0.939	1.00
192_P	196_E	0.934	1.00
231_V	235_L	0.934	1.00
11_A	18_V	0.933	1.00
175_I	180_Q	0.932	1.00
24_G	37_F	0.931	1.00
80_L	84_A	0.923	1.00
324_K	327_R	0.921	1.00
89_E	300_Q	0.913	1.00
111_Q	115_D	0.909	1.00
171_V	205_L	0.902	1.00
122_M	306_L	0.894	1.00
170_A	291_V	0.894	1.00
244_L	270_V	0.889	1.00
48_N	51_A	0.883	1.00
83_A	299_I	0.883	1.00
286_P	289_S	0.877	1.00
134_D	139_A	0.875	1.00
162_D	320_T	0.873	1.00
264_V	270_V	0.870	1.00
181_E	216_L	0.865	1.00
190_D	195_I	0.860	1.00
21_V	37_F	0.860	1.00
47_P	52_R	0.860	1.00
229_E	232_E	0.855	1.00
305_R	308_F	0.853	1.00
159_V	305_R	0.852	1.00
85_R	300_Q	0.850	1.00
202_K	212_L	0.849	1.00
75_Y	295_V	0.849	1.00
183_A	244_L	0.845	1.00
161_C	294_P	0.845	1.00
294_P	321_F	0.844	1.00
165_Q	323_G	0.839	1.00
198_L	217_I	0.835	1.00
187_G	222_W	0.828	1.00
51_A	54_L	0.827	1.00
160_W	320_T	0.826	1.00
130_V	134_D	0.825	1.00
163_H	197_R	0.823	1.00
62_L	122_M	0.823	1.00
161_C	323_G	0.823	1.00
13_V	36_V	0.818	1.00
120_A	310_L	0.816	1.00
216_L	237_R	0.811	1.00
231_V	258_A	0.811	1.00
235_L	258_A	0.811	1.00
327_R	331_L	0.810	1.00
226_S	230_G	0.808	1.00
249_D	277_D	0.806	1.00
203_D	206_A	0.806	1.00
79_L	147_L	0.805	1.00
186_T	198_L	0.804	1.00
85_R	89_E	0.804	1.00
131_D	134_D	0.803	1.00
303_I	307_I	0.802	1.00
180_Q	210_I	0.801	1.00
259_L	272_V	0.800	1.00
174_L	273_I	0.797	1.00
277_D	326_I	0.795	1.00
49_L	52_R	0.795	1.00
64_L	80_L	0.794	1.00
80_L	96_L	0.790	1.00
138_D	155_S	0.790	1.00
31_E	34_D	0.787	1.00
83_A	94_L	0.784	1.00
240_K	264_V	0.784	1.00
161_C	293_I	0.780	1.00
173_E	325_L	0.779	1.00
78_E	296_T	0.776	1.00
61_T	116_L	0.774	1.00
231_V	234_L	0.770	1.00
82_H	86_M	0.770	1.00
274_G	290_S	0.766	1.00
102_S	105_E	0.766	1.00
196_E	200_G	0.763	1.00
82_H	300_Q	0.758	1.00
95_L	118_C	0.756	1.00
16_A	20_R	0.754	1.00
114_L	140_H	0.752	1.00
220_G	251_M	0.752	1.00
185_L	246_A	0.752	1.00
253_I	284_T	0.752	1.00
235_L	262_R	0.752	1.00
257_K	260_H	0.752	1.00
31_E	35_R	0.750	1.00
59_T	119_D	0.750	1.00
252_A	274_G	0.743	1.00
81_F	84_A	0.742	1.00
108_Q	111_Q	0.742	1.00
212_L	215_K	0.741	1.00
105_E	109_A	0.736	1.00
20_R	27_Y	0.734	1.00
218_A	237_R	0.733	1.00
184_F	245_V	0.733	1.00
132_E	135_D	0.732	1.00
162_D	322_S	0.732	1.00
67_T	76_F	0.729	1.00
107_R	132_E	0.728	1.00
205_L	212_L	0.727	1.00
169_N	291_V	0.725	1.00
100_K	105_E	0.720	1.00
58_S	119_D	0.718	1.00
259_L	266_V	0.718	1.00
46_R	115_D	0.715	1.00
17_T	20_R	0.714	1.00
95_L	116_L	0.714	1.00
233_M	236_E	0.713	1.00
146_V	156_S	0.709	1.00
257_K	287_A	0.701	1.00
138_D	144_I	0.698	1.00
131_D	135_D	0.696	1.00
281_A	284_T	0.695	1.00
20_R	26_G	0.694	1.00
257_K	261_E	0.693	1.00
21_V	33_K	0.692	1.00
218_A	234_L	0.692	1.00
122_M	147_L	0.692	1.00
62_L	303_I	0.690	1.00
277_D	281_A	0.688	1.00
308_F	312_G	0.687	1.00
84_A	94_L	0.687	1.00
168_F	200_G	0.681	1.00
34_D	41_E	0.680	1.00
245_V	273_I	0.678	1.00
63_G	121_I	0.678	1.00
289_S	331_L	0.678	1.00
146_V	151_L	0.674	1.00
137_I	144_I	0.673	1.00
184_F	201_Y	0.673	1.00
120_A	145_M	0.672	1.00
175_I	205_L	0.668	1.00
65_V	109_A	0.666	1.00
202_K	217_I	0.662	1.00
135_D	139_A	0.659	1.00
144_I	156_S	0.656	1.00
13_V	32_T	0.656	1.00
194_S	222_W	0.654	1.00
242_S	271_S	0.651	1.00
145_M	306_L	0.646	1.00
182_I	242_S	0.646	1.00
220_G	226_S	0.643	1.00
169_N	173_E	0.642	1.00
84_A	98_D	0.642	1.00
276_D	293_I	0.640	1.00
227_G	230_G	0.638	1.00
46_R	111_Q	0.637	1.00
78_E	295_V	0.635	1.00
58_S	311_D	0.634	1.00
121_I	142_Q	0.629	1.00
114_L	142_Q	0.628	1.00
256_M	260_H	0.628	1.00
174_L	245_V	0.623	1.00
257_K	285_V	0.622	1.00
35_R	38_Q	0.622	1.00
110_I	121_I	0.621	1.00
104_E	108_Q	0.620	1.00
249_D	252_A	0.618	1.00
145_M	309_M	0.617	1.00
173_E	289_S	0.617	1.00
222_W	247_S	0.616	1.00
280_I	284_T	0.614	1.00
81_F	296_T	0.611	1.00
59_T	93_Q	0.610	1.00
75_Y	79_L	0.609	1.00
27_Y	32_T	0.607	1.00
41_E	44_G	0.607	1.00
5_L	55_S	0.607	1.00
237_R	240_K	0.607	1.00
231_V	254_G	0.604	1.00
148_N	193_T	0.603	1.00
237_R	241_F	0.602	1.00
253_I	278_I	0.601	1.00
312_G	315_F	0.598	1.00
148_N	163_H	0.597	1.00
287_A	328_R	0.593	1.00
168_F	171_V	0.592	1.00
198_L	219_N	0.591	1.00
120_A	302_I	0.591	1.00
62_L	310_L	0.590	1.00
134_D	138_D	0.589	1.00
7_V	18_V	0.589	1.00
145_M	159_V	0.589	1.00
73_G	250_D	0.588	1.00
248_N	276_D	0.587	1.00
79_L	295_V	0.587	1.00
18_V	40_V	0.584	1.00
163_H	196_E	0.583	1.00
183_A	216_L	0.583	1.00
18_V	21_V	0.581	1.00
259_L	262_R	0.581	1.00
150_R	158_S	0.580	1.00
46_R	50_L	0.577	1.00
186_T	217_I	0.577	1.00
187_G	194_S	0.576	1.00
97_A	112_Y	0.576	1.00
225_A	228_A	0.573	1.00
20_R	28_V	0.573	1.00
87_A	92_R	0.573	1.00
201_Y	212_L	0.572	1.00
186_T	219_N	0.571	1.00
248_N	251_M	0.571	1.00
305_R	309_M	0.570	1.00
92_R	310_L	0.570	1.00
245_V	275_F	0.567	1.00
224_P	280_I	0.565	1.00
103_A	107_R	0.563	1.00
146_V	158_S	0.563	1.00
224_P	254_G	0.562	1.00
62_L	120_A	0.562	1.00
194_S	247_S	0.560	1.00
82_H	295_V	0.559	1.00
202_K	214_E	0.559	1.00
92_R	119_D	0.558	1.00
62_L	92_R	0.558	1.00
289_S	325_L	0.557	1.00
145_M	305_R	0.555	1.00
111_Q	114_L	0.554	1.00
281_A	288_L	0.552	1.00
159_V	301_E	0.551	1.00
253_I	280_I	0.551	1.00
291_V	323_G	0.549	1.00
228_A	254_G	0.549	1.00
298_M	321_F	0.548	1.00
222_W	251_M	0.547	1.00
264_V	267_P	0.543	1.00
260_H	265_A	0.542	1.00
228_A	231_V	0.542	1.00
68_N	72_H	0.542	1.00
282_P	287_A	0.540	1.00
173_E	273_I	0.540	1.00
145_M	302_I	0.540	1.00
113_L	118_C	0.539	1.00
182_I	201_Y	0.539	1.00
170_A	243_A	0.537	1.00
198_L	212_L	0.533	1.00
266_V	269_Q	0.532	1.00
61_T	119_D	0.530	1.00
215_K	237_R	0.529	1.00
320_T	323_G	0.529	1.00
25_N	28_V	0.528	1.00
284_T	287_A	0.527	1.00
87_A	307_I	0.527	1.00
76_F	124_Y	0.527	1.00
296_T	299_I	0.526	1.00
82_H	85_R	0.523	1.00
246_A	274_G	0.521	1.00
230_G	234_L	0.520	1.00
28_V	33_K	0.520	1.00
281_A	290_S	0.520	1.00
257_K	282_P	0.515	1.00
235_L	259_L	0.515	1.00
108_Q	112_Y	0.515	1.00
6_E	10_R	0.514	1.00
81_F	100_K	0.514	1.00
177_A	242_S	0.514	1.00
255_A	259_L	0.513	1.00
241_F	244_L	0.513	1.00
13_V	18_V	0.512	1.00
83_A	87_A	0.512	1.00
181_E	238_G	0.511	1.00
181_E	241_F	0.511	1.00
275_F	293_I	0.510	1.00
104_E	107_R	0.510	1.00
130_V	133_I	0.509	1.00
112_Y	115_D	0.509	1.00
52_R	56_A	0.508	1.00
53_N	56_A	0.508	1.00
185_L	230_G	0.508	1.00
309_M	312_G	0.507	1.00
172_A	175_I	0.506	1.00
138_D	156_S	0.506	1.00
24_G	27_Y	0.505	1.00
273_I	331_L	0.505	1.00
78_E	279_A	0.504	1.00
301_E	308_F	0.504	1.00
261_E	285_V	0.503	1.00
160_W	163_H	0.503	1.00
118_C	121_I	0.503	1.00
206_A	209_G	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3dbiA	2	0.8244	100	0.04	Contact Map
2hsgA	1	0.9702	100	0.071	Contact Map
4o5aA	2	0.8006	100	0.071	Contact Map
1qpzA	2	0.9881	100	0.075	Contact Map
2o20A	2	0.8155	100	0.077	Contact Map
3bilA	2	0.7619	100	0.08	Contact Map
3ctpA	2	0.7857	100	0.081	Contact Map
3kjxA	2	0.9821	100	0.085	Contact Map
3e3mA	2	0.7976	100	0.085	Contact Map
1jyeA	2	0.8006	100	0.09	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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