GREMLIN Database
ASCG - HTH-type transcriptional regulator AscG
UniProt: P24242 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10087
Length: 336 (325)
Sequences: 37130 (27025)
Seq/√Len: 1499.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
164_K203_D3.3891.00
10_R42_E3.1291.00
265_A268_E3.0571.00
179_H242_S2.9531.00
198_L202_K2.6611.00
120_A306_L2.6081.00
170_A273_I2.5901.00
179_H271_S2.4091.00
277_D292_K2.3881.00
157_H309_M2.3401.00
30_Q34_D2.3021.00
168_F207_Q2.3011.00
38_Q42_E2.2631.00
228_A261_E2.2341.00
232_E262_R2.1861.00
86_M89_E2.1831.00
34_D38_Q2.1751.00
86_M304_G2.1671.00
172_A204_A2.1311.00
168_F204_A2.1211.00
232_E258_A2.1131.00
165_Q169_N2.1051.00
175_I208_H2.0761.00
168_F203_D2.0681.00
301_E304_G2.0271.00
21_V36_V1.9961.00
87_A303_I1.9671.00
86_M300_Q1.9551.00
164_K199_A1.9311.00
33_K37_F1.9231.00
5_L15_K1.8841.00
174_L243_A1.8781.00
22_L40_V1.8691.00
166_T275_F1.8621.00
167_S171_V1.8221.00
172_A176_N1.8201.00
10_R39_A1.8161.00
177_A331_L1.8141.00
259_L270_V1.8111.00
292_K324_K1.7971.00
82_H299_I1.7951.00
167_S245_V1.7821.00
308_F313_G1.7801.00
171_V201_Y1.7791.00
236_E262_R1.7761.00
172_A208_H1.7721.00
85_R296_T1.7471.00
168_F172_A1.7251.00
11_A39_A1.7201.00
228_A258_A1.7171.00
181_E213_N1.7111.00
183_A241_F1.7041.00
264_V269_Q1.6891.00
227_G254_G1.6841.00
231_V255_A1.6611.00
246_A255_A1.6491.00
63_G118_C1.6421.00
294_P297_E1.6391.00
82_H296_T1.6381.00
86_M90_K1.6341.00
258_A262_R1.6301.00
184_F247_S1.6241.00
260_H285_V1.6121.00
147_L302_I1.6091.00
169_N323_G1.6081.00
265_A269_Q1.5901.00
287_A329_D1.5741.00
173_E177_A1.5711.00
173_E176_N1.5711.00
218_A233_M1.5641.00
37_F41_E1.5591.00
165_Q168_F1.5441.00
181_E240_K1.5421.00
90_K307_I1.5411.00
175_I204_A1.5211.00
258_A261_E1.5171.00
199_A203_D1.4991.00
297_E301_E1.4931.00
173_E327_R1.4681.00
307_I311_D1.4611.00
162_D165_Q1.4471.00
202_K206_A1.4461.00
37_F40_V1.4441.00
7_V39_A1.4431.00
21_V40_V1.4261.00
60_Q119_D1.4201.00
196_E199_A1.4161.00
204_A207_Q1.4131.00
297_E300_Q1.3851.00
181_E242_S1.3701.00
228_A257_K1.3671.00
10_R43_S1.3671.00
259_L264_V1.3631.00
86_M303_I1.3541.00
277_D328_R1.3501.00
228_A232_E1.3481.00
166_T323_G1.3371.00
232_E261_E1.3281.00
5_L9_K1.3071.00
171_V175_I1.3021.00
60_Q92_R1.3011.00
35_R39_A1.3001.00
231_V244_L1.2921.00
30_Q33_K1.2911.00
183_A234_L1.2901.00
39_A42_E1.2861.00
171_V204_A1.2721.00
122_M302_I1.2711.00
164_K168_F1.2641.00
6_E9_K1.2611.00
232_E236_E1.2611.00
62_L87_A1.2571.00
169_N172_A1.2491.00
304_G308_F1.2471.00
20_R25_N1.2331.00
29_S32_T1.2321.00
173_E331_L1.2311.00
171_V200_G1.2251.00
213_N216_L1.2201.00
231_V259_L1.2181.00
97_A109_A1.2151.00
87_A94_L1.2141.00
167_S200_G1.2131.00
200_G204_A1.2111.00
39_A43_S1.2031.00
256_M272_V1.2031.00
63_G113_L1.2011.00
32_T35_R1.1931.00
172_A207_Q1.1891.00
233_M237_R1.1831.00
296_T300_Q1.1771.00
164_K196_E1.1721.00
221_K226_S1.1691.00
83_A303_I1.1661.00
201_Y205_L1.1651.00
204_A208_H1.1591.00
21_V28_V1.1521.00
7_V43_S1.1501.00
7_V11_A1.1461.00
230_G233_M1.1441.00
4_M15_K1.1431.00
97_A113_L1.1411.00
61_T93_Q1.1391.00
64_L83_A1.1351.00
90_K304_G1.1181.00
34_D37_F1.1131.00
164_K200_G1.1081.00
61_T95_L1.1071.00
184_F198_L1.1061.00
179_H243_A1.1041.00
225_A229_E1.1011.00
273_I289_S1.1001.00
301_E305_R1.0941.00
83_A122_M1.0891.00
170_A245_V1.0821.00
271_S331_L1.0811.00
223_T226_S1.0811.00
84_A88_E1.0801.00
38_Q41_E1.0781.00
24_G33_K1.0761.00
185_L255_A1.0731.00
254_G258_A1.0711.00
203_D207_Q1.0711.00
182_I205_L1.0661.00
181_E239_A1.0631.00
244_L255_A1.0631.00
299_I303_I1.0601.00
218_A230_G1.0491.00
4_M18_V1.0471.00
199_A202_K1.0451.00
195_I199_A1.0371.00
180_Q242_S1.0321.00
175_I210_I1.0291.00
205_L210_I1.0281.00
107_R111_Q1.0251.00
238_G241_F1.0251.00
64_L94_L1.0241.00
189_M219_N1.0231.00
92_R307_I1.0231.00
301_E321_F1.0161.00
177_A327_R1.0091.00
48_N54_L1.0091.00
300_Q304_G1.0051.00
157_H305_R1.0021.00
246_A251_M1.0011.00
177_A271_S0.9991.00
50_L53_N0.9961.00
88_E105_E0.9941.00
292_K326_I0.9921.00
201_Y245_V0.9901.00
226_S229_E0.9881.00
90_K311_D0.9881.00
105_E108_Q0.9871.00
176_N208_H0.9861.00
229_E233_M0.9861.00
249_D290_S0.9801.00
246_A252_A0.9751.00
182_I243_A0.9741.00
40_V43_S0.9711.00
165_Q322_S0.9691.00
260_H287_A0.9691.00
249_D274_G0.9681.00
306_L310_L0.9541.00
224_P257_K0.9511.00
256_M266_V0.9481.00
256_M284_T0.9461.00
294_P324_K0.9461.00
81_F85_R0.9451.00
227_G231_V0.9391.00
192_P196_E0.9341.00
231_V235_L0.9341.00
11_A18_V0.9331.00
175_I180_Q0.9321.00
24_G37_F0.9311.00
80_L84_A0.9231.00
324_K327_R0.9211.00
89_E300_Q0.9131.00
111_Q115_D0.9091.00
171_V205_L0.9021.00
122_M306_L0.8941.00
170_A291_V0.8941.00
244_L270_V0.8891.00
48_N51_A0.8831.00
83_A299_I0.8831.00
286_P289_S0.8771.00
134_D139_A0.8751.00
162_D320_T0.8731.00
264_V270_V0.8701.00
181_E216_L0.8651.00
190_D195_I0.8601.00
21_V37_F0.8601.00
47_P52_R0.8601.00
229_E232_E0.8551.00
305_R308_F0.8531.00
159_V305_R0.8521.00
85_R300_Q0.8501.00
202_K212_L0.8491.00
75_Y295_V0.8491.00
183_A244_L0.8451.00
161_C294_P0.8451.00
294_P321_F0.8441.00
165_Q323_G0.8391.00
198_L217_I0.8351.00
187_G222_W0.8281.00
51_A54_L0.8271.00
160_W320_T0.8261.00
130_V134_D0.8251.00
163_H197_R0.8231.00
62_L122_M0.8231.00
161_C323_G0.8231.00
13_V36_V0.8181.00
120_A310_L0.8161.00
216_L237_R0.8111.00
231_V258_A0.8111.00
235_L258_A0.8111.00
327_R331_L0.8101.00
226_S230_G0.8081.00
249_D277_D0.8061.00
203_D206_A0.8061.00
79_L147_L0.8051.00
186_T198_L0.8041.00
85_R89_E0.8041.00
131_D134_D0.8031.00
303_I307_I0.8021.00
180_Q210_I0.8011.00
259_L272_V0.8001.00
174_L273_I0.7971.00
277_D326_I0.7951.00
49_L52_R0.7951.00
64_L80_L0.7941.00
80_L96_L0.7901.00
138_D155_S0.7901.00
31_E34_D0.7871.00
83_A94_L0.7841.00
240_K264_V0.7841.00
161_C293_I0.7801.00
173_E325_L0.7791.00
78_E296_T0.7761.00
61_T116_L0.7741.00
231_V234_L0.7701.00
82_H86_M0.7701.00
274_G290_S0.7661.00
102_S105_E0.7661.00
196_E200_G0.7631.00
82_H300_Q0.7581.00
95_L118_C0.7561.00
16_A20_R0.7541.00
114_L140_H0.7521.00
220_G251_M0.7521.00
185_L246_A0.7521.00
253_I284_T0.7521.00
235_L262_R0.7521.00
257_K260_H0.7521.00
31_E35_R0.7501.00
59_T119_D0.7501.00
252_A274_G0.7431.00
81_F84_A0.7421.00
108_Q111_Q0.7421.00
212_L215_K0.7411.00
105_E109_A0.7361.00
20_R27_Y0.7341.00
218_A237_R0.7331.00
184_F245_V0.7331.00
132_E135_D0.7321.00
162_D322_S0.7321.00
67_T76_F0.7291.00
107_R132_E0.7281.00
205_L212_L0.7271.00
169_N291_V0.7251.00
100_K105_E0.7201.00
58_S119_D0.7181.00
259_L266_V0.7181.00
46_R115_D0.7151.00
17_T20_R0.7141.00
95_L116_L0.7141.00
233_M236_E0.7131.00
146_V156_S0.7091.00
257_K287_A0.7011.00
138_D144_I0.6981.00
131_D135_D0.6961.00
281_A284_T0.6951.00
20_R26_G0.6941.00
257_K261_E0.6931.00
21_V33_K0.6921.00
218_A234_L0.6921.00
122_M147_L0.6921.00
62_L303_I0.6901.00
277_D281_A0.6881.00
308_F312_G0.6871.00
84_A94_L0.6871.00
168_F200_G0.6811.00
34_D41_E0.6801.00
245_V273_I0.6781.00
63_G121_I0.6781.00
289_S331_L0.6781.00
146_V151_L0.6741.00
137_I144_I0.6731.00
184_F201_Y0.6731.00
120_A145_M0.6721.00
175_I205_L0.6681.00
65_V109_A0.6661.00
202_K217_I0.6621.00
135_D139_A0.6591.00
144_I156_S0.6561.00
13_V32_T0.6561.00
194_S222_W0.6541.00
242_S271_S0.6511.00
145_M306_L0.6461.00
182_I242_S0.6461.00
220_G226_S0.6431.00
169_N173_E0.6421.00
84_A98_D0.6421.00
276_D293_I0.6401.00
227_G230_G0.6381.00
46_R111_Q0.6371.00
78_E295_V0.6351.00
58_S311_D0.6341.00
121_I142_Q0.6291.00
114_L142_Q0.6281.00
256_M260_H0.6281.00
174_L245_V0.6231.00
257_K285_V0.6221.00
35_R38_Q0.6221.00
110_I121_I0.6211.00
104_E108_Q0.6201.00
249_D252_A0.6181.00
145_M309_M0.6171.00
173_E289_S0.6171.00
222_W247_S0.6161.00
280_I284_T0.6141.00
81_F296_T0.6111.00
59_T93_Q0.6101.00
75_Y79_L0.6091.00
27_Y32_T0.6071.00
41_E44_G0.6071.00
5_L55_S0.6071.00
237_R240_K0.6071.00
231_V254_G0.6041.00
148_N193_T0.6031.00
237_R241_F0.6021.00
253_I278_I0.6011.00
312_G315_F0.5981.00
148_N163_H0.5971.00
287_A328_R0.5931.00
168_F171_V0.5921.00
198_L219_N0.5911.00
120_A302_I0.5911.00
62_L310_L0.5901.00
134_D138_D0.5891.00
7_V18_V0.5891.00
145_M159_V0.5891.00
73_G250_D0.5881.00
248_N276_D0.5871.00
79_L295_V0.5871.00
18_V40_V0.5841.00
163_H196_E0.5831.00
183_A216_L0.5831.00
18_V21_V0.5811.00
259_L262_R0.5811.00
150_R158_S0.5801.00
46_R50_L0.5771.00
186_T217_I0.5771.00
187_G194_S0.5761.00
97_A112_Y0.5761.00
225_A228_A0.5731.00
20_R28_V0.5731.00
87_A92_R0.5731.00
201_Y212_L0.5721.00
186_T219_N0.5711.00
248_N251_M0.5711.00
305_R309_M0.5701.00
92_R310_L0.5701.00
245_V275_F0.5671.00
224_P280_I0.5651.00
103_A107_R0.5631.00
146_V158_S0.5631.00
224_P254_G0.5621.00
62_L120_A0.5621.00
194_S247_S0.5601.00
82_H295_V0.5591.00
202_K214_E0.5591.00
92_R119_D0.5581.00
62_L92_R0.5581.00
289_S325_L0.5571.00
145_M305_R0.5551.00
111_Q114_L0.5541.00
281_A288_L0.5521.00
159_V301_E0.5511.00
253_I280_I0.5511.00
291_V323_G0.5491.00
228_A254_G0.5491.00
298_M321_F0.5481.00
222_W251_M0.5471.00
264_V267_P0.5431.00
260_H265_A0.5421.00
228_A231_V0.5421.00
68_N72_H0.5421.00
282_P287_A0.5401.00
173_E273_I0.5401.00
145_M302_I0.5401.00
113_L118_C0.5391.00
182_I201_Y0.5391.00
170_A243_A0.5371.00
198_L212_L0.5331.00
266_V269_Q0.5321.00
61_T119_D0.5301.00
215_K237_R0.5291.00
320_T323_G0.5291.00
25_N28_V0.5281.00
284_T287_A0.5271.00
87_A307_I0.5271.00
76_F124_Y0.5271.00
296_T299_I0.5261.00
82_H85_R0.5231.00
246_A274_G0.5211.00
230_G234_L0.5201.00
28_V33_K0.5201.00
281_A290_S0.5201.00
257_K282_P0.5151.00
235_L259_L0.5151.00
108_Q112_Y0.5151.00
6_E10_R0.5141.00
81_F100_K0.5141.00
177_A242_S0.5141.00
255_A259_L0.5131.00
241_F244_L0.5131.00
13_V18_V0.5121.00
83_A87_A0.5121.00
181_E238_G0.5111.00
181_E241_F0.5111.00
275_F293_I0.5101.00
104_E107_R0.5101.00
130_V133_I0.5091.00
112_Y115_D0.5091.00
52_R56_A0.5081.00
53_N56_A0.5081.00
185_L230_G0.5081.00
309_M312_G0.5071.00
172_A175_I0.5061.00
138_D156_S0.5061.00
24_G27_Y0.5051.00
273_I331_L0.5051.00
78_E279_A0.5041.00
301_E308_F0.5041.00
261_E285_V0.5031.00
160_W163_H0.5031.00
118_C121_I0.5031.00
206_A209_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3dbiA 2 0.8244 100 0.04 Contact Map
2hsgA 1 0.9702 100 0.071 Contact Map
4o5aA 2 0.8006 100 0.071 Contact Map
1qpzA 2 0.9881 100 0.075 Contact Map
2o20A 2 0.8155 100 0.077 Contact Map
3bilA 2 0.7619 100 0.08 Contact Map
3ctpA 2 0.7857 100 0.081 Contact Map
3kjxA 2 0.9821 100 0.085 Contact Map
3e3mA 2 0.7976 100 0.085 Contact Map
1jyeA 2 0.8006 100 0.09 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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