GREMLIN Database
PTIBC - PTS system arbutin-, cellobiose-, and salicin-specific EIIBC component
UniProt: P24241 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10086
Length: 485 (370)
Sequences: 4438 (2519)
Seq/√Len: 131.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
402_V442_L4.1751.00
395_S446_L4.0031.00
347_A448_F3.7971.00
299_A397_F3.7791.00
227_M263_A3.6961.00
254_L258_I3.3501.00
231_L255_I3.1701.00
166_A180_A2.9571.00
402_V435_W2.9141.00
398_I446_L2.7851.00
100_R105_G2.7501.00
437_F441_A2.6951.00
242_T250_L2.6831.00
391_A454_L2.5931.00
341_L382_A2.5681.00
167_A181_I2.4501.00
402_V406_A2.4471.00
284_T288_Y2.4201.00
320_T327_E2.3941.00
390_I394_I2.3641.00
343_G443_A2.3411.00
406_A435_W2.3401.00
167_A177_M2.2881.00
239_D247_K2.2801.00
238_V254_L2.2701.00
451_T455_G2.2111.00
237_W241_I2.2001.00
163_L185_G2.1761.00
130_L134_L2.1261.00
345_S377_A2.1241.00
351_K455_G2.1171.00
352_T357_L2.0791.00
350_W451_T2.0461.00
349_A362_L2.0241.00
449_I453_L2.0181.00
273_W277_A2.0081.00
230_C262_L1.9971.00
435_W438_A1.9551.00
246_T250_L1.9201.00
343_G444_V1.9171.00
233_Y236_R1.8981.00
298_G396_G1.8951.00
134_L139_V1.8941.00
109_A173_F1.8851.00
346_L365_A1.8601.00
403_A439_V1.8591.00
276_S280_A1.8491.00
450_L454_L1.8181.00
391_A450_L1.8111.00
343_G447_S1.8061.00
295_A401_A1.8041.00
128_K155_D1.7911.00
303_L393_L1.7871.00
391_A395_S1.7821.00
342_G368_A1.7631.00
163_L181_I1.7541.00
445_V449_I1.7491.00
350_W447_S1.7271.00
238_V242_T1.7261.00
226_V271_G1.7181.00
401_A405_M1.7121.00
233_Y237_W1.6951.00
385_L388_P1.6771.00
155_D159_F1.6731.00
446_L450_L1.6621.00
294_V400_G1.6351.00
175_T228_T1.6331.00
108_D172_K1.6221.00
102_I105_G1.6091.00
326_K409_A1.5931.00
378_L389_L1.5921.00
169_A229_W1.5871.00
171_I177_M1.5871.00
234_I259_A1.5761.00
250_L254_L1.5661.00
295_A397_F1.5611.00
229_W232_S1.5371.00
348_V361_A1.5311.00
281_L284_T1.5061.00
234_I258_I1.5031.00
167_A178_S1.4961.00
299_A303_L1.4841.00
170_A228_T1.4721.00
229_W233_Y1.4621.00
350_W448_F1.4581.00
277_A281_L1.4441.00
398_I442_L1.4391.00
385_L456_F1.4141.00
302_P338_N1.4101.00
259_A263_A1.4021.00
387_R457_E1.3961.00
102_I106_I1.3961.00
402_V439_V1.3901.00
126_M253_M1.3741.00
298_G400_G1.3691.00
291_W405_M1.3551.00
448_F452_L1.3371.00
230_C259_A1.3271.00
291_W401_A1.3211.00
168_S178_S1.3191.00
351_K456_F1.3181.00
395_S447_S1.3121.00
247_K251_K1.3101.00
346_L350_W1.3031.00
180_A184_A1.2981.00
348_V352_T1.2961.00
230_C267_I1.2941.00
184_A255_I1.2901.00
365_A369_I1.2821.00
170_A177_M1.2761.00
347_A452_L1.2721.00
395_S449_I1.2641.00
402_V438_A1.2621.00
335_I436_V1.2491.00
348_V357_L1.2481.00
167_A182_A1.2461.00
277_A280_A1.2451.00
165_V221_V1.2441.00
274_I277_A1.2331.00
434_V437_F1.2251.00
357_L385_L1.2121.00
283_Y287_G1.2121.00
294_V404_G1.2111.00
294_V401_A1.2101.00
436_V440_M1.2090.99
238_V251_K1.2090.99
183_I256_V1.2070.99
394_I450_L1.2010.99
301_W333_S1.2010.99
114_M221_V1.1970.99
222_I226_V1.1950.99
153_I260_A1.1920.99
387_R455_G1.1690.99
149_I212_V1.1670.99
228_T232_S1.1530.99
378_L392_S1.1500.99
349_A358_R1.1480.99
340_S392_S1.1460.99
399_C442_L1.1450.99
363_A367_S1.1440.99
94_K97_L1.1430.99
131_A147_L1.1410.99
278_I304_L1.1400.99
399_C443_A1.1380.99
141_T144_S1.1290.99
124_G157_A1.1290.99
127_V154_G1.1280.99
146_T149_I1.1270.99
117_L168_S1.1200.99
175_T231_L1.1190.99
156_G185_G1.1150.99
403_A408_L1.1090.99
282_V329_M1.1090.99
109_A113_T1.1020.99
304_L313_F1.1010.99
176_N235_E1.0940.99
170_A180_A1.0880.99
169_A225_L1.0860.99
299_A393_L1.0850.99
336_G403_A1.0800.99
408_L439_V1.0780.99
117_L161_L1.0630.99
440_M444_V1.0630.99
289_L292_L1.0610.99
295_A398_I1.0570.99
160_F190_P1.0560.99
237_W240_S1.0550.99
184_A224_A1.0520.99
432_S435_W1.0500.99
357_L361_A1.0490.99
299_A390_I1.0470.99
343_G347_A1.0460.99
183_I224_A1.0440.99
349_A361_A1.0420.98
382_A388_P1.0410.98
98_T102_I1.0410.98
232_S236_R1.0410.98
351_K451_T1.0390.98
434_V438_A1.0380.98
173_F229_W1.0370.98
354_N357_L1.0270.98
402_V405_M1.0270.98
339_L342_G1.0230.98
395_S399_C1.0230.98
153_I186_V1.0220.98
262_L267_I1.0120.98
106_I109_A1.0100.98
329_M332_P1.0050.98
355_P358_R1.0020.98
186_V260_A0.9980.98
244_A247_K0.9890.98
335_I420_T0.9840.98
391_A451_T0.9830.98
243_P246_T0.9830.98
166_A224_A0.9820.98
319_Q323_E0.9820.98
421_S437_F0.9800.98
174_K236_R0.9790.98
344_S382_A0.9740.98
242_T246_T0.9730.98
271_G275_G0.9710.98
344_S392_S0.9700.98
320_T324_T0.9690.98
234_I238_V0.9640.97
165_V224_A0.9610.97
457_E460_P0.9610.97
414_A423_Q0.9600.97
266_L270_I0.9600.97
230_C234_I0.9590.97
113_T225_L0.9590.97
157_A164_M0.9520.97
112_G172_K0.9480.97
98_T101_R0.9480.97
188_V218_T0.9440.97
406_A438_A0.9400.97
406_A442_L0.9370.97
341_L392_S0.9350.97
148_T151_N0.9300.97
227_M259_A0.9260.97
388_P391_A0.9260.97
343_G369_I0.9230.97
175_T180_A0.9200.97
170_A175_T0.9120.97
166_A228_T0.9110.96
173_F232_S0.9090.96
239_D251_K0.9090.96
273_W276_S0.9060.96
98_T105_G0.9030.96
222_I271_G0.9030.96
95_P98_T0.9030.96
350_W455_G0.9020.96
193_I197_A0.9010.96
441_A445_V0.8980.96
99_L105_G0.8970.96
227_M262_L0.8970.96
164_M182_A0.8940.96
108_D112_G0.8930.96
442_L446_L0.8900.96
340_S344_S0.8900.96
348_V381_V0.8880.96
452_L455_G0.8830.96
382_A392_S0.8810.96
351_K452_L0.8760.96
358_R362_L0.8740.96
346_L448_F0.8720.95
368_A374_S0.8720.95
258_I261_P0.8660.95
337_A341_L0.8640.95
441_A449_I0.8640.95
182_A186_V0.8620.95
270_I274_I0.8600.95
303_L307_T0.8560.95
440_M443_A0.8560.95
155_D189_H0.8550.95
336_G396_G0.8550.95
226_V267_I0.8550.95
267_I271_G0.8540.95
344_S388_P0.8540.95
303_L389_L0.8530.95
135_E147_L0.8510.95
217_Y223_P0.8510.95
183_I259_A0.8500.95
164_M185_G0.8500.95
443_A447_S0.8490.95
163_L182_A0.8470.95
131_A154_G0.8450.95
408_L435_W0.8440.95
169_A173_F0.8430.95
174_K180_A0.8420.95
313_F317_I0.8410.95
391_A449_I0.8390.94
307_T379_Y0.8300.94
442_L445_V0.8290.94
357_L458_D0.8260.94
374_S377_A0.8250.94
109_A229_W0.8210.94
200_A203_E0.8210.94
300_L303_L0.8200.94
452_L456_F0.8190.94
97_L105_G0.8180.94
284_T290_G0.8180.94
195_L205_V0.8170.94
175_T235_E0.8160.94
392_S446_L0.8160.94
369_I418_L0.8150.94
163_L184_A0.8120.93
294_V298_G0.8110.93
453_L457_E0.8080.93
461_V464_A0.8080.93
146_T207_F0.8060.93
341_L377_A0.8060.93
224_A228_T0.8050.93
294_V333_S0.8020.93
371_A417_G0.7980.93
124_G156_G0.7980.93
262_L266_L0.7970.93
388_P451_T0.7960.93
89_A96_K0.7950.93
297_M304_L0.7940.93
336_G399_C0.7930.93
280_A283_Y0.7870.92
460_P465_A0.7830.92
302_P337_A0.7830.92
275_G309_M0.7810.92
230_C233_Y0.7770.92
166_A184_A0.7770.92
351_K458_D0.7760.92
148_T152_V0.7740.92
398_I402_V0.7720.92
242_T251_K0.7700.91
351_K354_N0.7670.91
103_G106_I0.7630.91
390_I393_L0.7610.91
156_G186_V0.7580.91
167_A171_I0.7570.91
381_V385_L0.7550.91
166_A181_I0.7490.90
444_V447_S0.7480.90
348_V388_P0.7480.90
339_L417_G0.7450.90
357_L381_V0.7440.90
133_I137_S0.7400.90
179_L231_L0.7400.90
407_G431_M0.7370.90
341_L344_S0.7370.90
302_P378_L0.7370.90
132_M151_N0.7360.90
143_G148_T0.7300.89
174_K235_E0.7280.89
97_L100_R0.7280.89
134_L140_L0.7260.89
360_T364_A0.7260.89
297_M333_S0.7240.89
382_A389_L0.7240.89
395_S450_L0.7240.89
246_T371_A0.7220.89
340_S395_S0.7210.89
365_A368_A0.7200.89
297_M331_M0.7190.88
305_V337_A0.7170.88
298_G397_F0.7160.88
137_S140_L0.7150.88
454_L458_D0.7150.88
213_T272_I0.7100.88
352_T458_D0.7100.88
242_T254_L0.7090.88
296_I299_A0.7060.88
192_F196_M0.7060.88
341_L368_A0.7030.87
128_K158_F0.7030.87
235_E251_K0.7030.87
300_L393_L0.6990.87
387_R456_F0.6920.86
411_H427_P0.6900.86
94_K98_T0.6880.86
159_F218_T0.6870.86
339_L440_M0.6860.86
85_D445_V0.6860.86
241_I244_A0.6850.86
107_L383_I0.6840.86
255_I259_A0.6830.86
151_N155_D0.6820.86
119_P122_I0.6820.86
391_A453_L0.6790.85
323_E326_K0.6790.85
115_S311_R0.6790.85
124_G161_L0.6790.85
291_W295_A0.6770.85
129_L371_A0.6760.85
280_A284_T0.6760.85
164_M181_I0.6730.85
412_S423_Q0.6720.85
320_T323_E0.6720.85
240_S353_K0.6720.85
462_E465_A0.6710.85
184_A231_L0.6710.85
345_S365_A0.6690.85
290_G293_S0.6670.84
113_T173_F0.6670.84
261_P266_L0.6670.84
234_I255_I0.6660.84
295_A298_G0.6610.84
101_R104_A0.6610.84
418_L422_V0.6570.84
222_I306_M0.6560.83
257_L261_P0.6540.83
133_I139_V0.6540.83
400_G404_G0.6530.83
362_L366_A0.6510.83
295_A299_A0.6510.83
302_P389_L0.6500.83
384_R388_P0.6480.83
272_I276_S0.6470.83
174_K177_M0.6470.83
447_S455_G0.6470.83
133_I136_M0.6450.82
341_L374_S0.6440.82
330_V334_E0.6440.82
289_L293_S0.6430.82
288_Y292_L0.6410.82
347_A451_T0.6400.82
130_L133_I0.6390.82
457_E461_V0.6370.82
85_D89_A0.6370.82
120_A182_A0.6360.82
128_K159_F0.6360.82
180_A228_T0.6340.81
171_I174_K0.6330.81
387_R458_D0.6320.81
431_M434_V0.6290.81
89_A94_K0.6270.81
228_T231_L0.6270.81
118_I372_G0.6260.81
170_A231_L0.6230.80
125_S413_M0.6220.80
258_I262_L0.6220.80
165_V169_A0.6200.80
235_E239_D0.6190.80
94_K99_L0.6190.80
113_T169_A0.6170.80
297_M313_F0.6150.79
248_N251_K0.6140.79
183_I227_M0.6130.79
156_G189_H0.6130.79
194_E197_A0.6120.79
395_S398_I0.6090.79
270_I273_W0.6050.78
152_V189_H0.6030.78
389_L392_S0.6030.78
361_A365_A0.6020.78
128_K189_H0.6020.78
198_K203_E0.6020.78
339_L439_V0.5990.78
175_T232_S0.5930.77
345_S349_A0.5920.77
444_V448_F0.5920.77
391_A394_I0.5880.76
177_M228_T0.5860.76
337_A392_S0.5810.75
125_S129_L0.5810.75
126_M129_L0.5810.75
114_M315_P0.5800.75
131_A151_N0.5800.75
335_I403_A0.5800.75
345_S361_A0.5800.75
416_P420_T0.5780.75
338_N392_S0.5780.75
118_I417_G0.5780.75
408_L433_I0.5770.75
217_Y275_G0.5770.75
425_F432_S0.5760.75
206_E209_L0.5760.75
448_F451_T0.5750.75
178_S181_I0.5720.74
264_I269_P0.5720.74
134_L141_T0.5680.74
101_R105_G0.5650.73
369_I444_V0.5620.73
135_E151_N0.5600.73
421_S440_M0.5600.73
85_D88_P0.5590.73
338_N374_S0.5590.73
159_F190_P0.5590.73
147_L151_N0.5580.72
337_A399_C0.5570.72
411_H425_F0.5560.72
145_P148_T0.5560.72
300_L304_L0.5560.72
337_A378_L0.5550.72
359_Q363_A0.5540.72
454_L459_I0.5540.72
342_G365_A0.5510.72
309_M316_T0.5500.71
178_S182_A0.5490.71
302_P341_L0.5480.71
176_N239_D0.5480.71
84_G89_A0.5480.71
296_I300_L0.5480.71
353_K453_L0.5480.71
354_N459_I0.5470.71
175_T255_I0.5460.71
129_L294_V0.5460.71
297_M334_E0.5460.71
368_A377_A0.5450.71
120_A179_L0.5430.70
394_I397_F0.5430.70
293_S327_E0.5430.70
135_E139_V0.5420.70
110_L307_T0.5420.70
351_K387_R0.5420.70
388_P392_S0.5410.70
121_I311_R0.5410.70
145_P205_V0.5400.70
337_A374_S0.5400.70
85_D97_L0.5390.70
306_M378_L0.5360.69
123_G256_V0.5350.69
312_V315_P0.5340.69
161_L221_V0.5340.69
348_V385_L0.5340.69
234_I254_L0.5330.69
314_T317_I0.5330.69
222_I278_I0.5320.69
354_N458_D0.5320.69
318_I413_M0.5320.69
344_S348_V0.5310.69
199_A203_E0.5290.68
338_N369_I0.5280.68
398_I401_A0.5270.68
455_G458_D0.5270.68
120_A164_M0.5260.68
305_V341_L0.5250.68
338_N365_A0.5250.68
331_M416_P0.5230.68
279_S313_F0.5230.68
129_L389_L0.5220.67
85_D461_V0.5220.67
89_A97_L0.5220.67
182_A256_V0.5200.67
175_T414_A0.5200.67
231_L259_A0.5200.67
158_F161_L0.5190.67
397_F401_A0.5190.67
127_V253_M0.5180.67
138_G142_K0.5160.67
153_I259_A0.5160.67
350_W452_L0.5160.67
435_W442_L0.5150.66
285_I296_I0.5150.66
96_K105_G0.5150.66
342_G444_V0.5150.66
364_A367_S0.5140.66
155_D220_T0.5140.66
301_W315_P0.5130.66
354_N457_E0.5120.66
204_H213_T0.5110.66
230_C258_I0.5110.66
317_I331_M0.5110.66
345_S382_A0.5100.66
452_L457_E0.5100.66
146_T208_A0.5090.66
342_G346_L0.5080.65
111_I311_R0.5080.65
302_P374_S0.5080.65
142_K146_T0.5080.65
337_A416_P0.5050.65
339_L444_V0.5050.65
301_W330_V0.5050.65
192_F264_I0.5040.65
454_L461_V0.5040.65
342_G345_S0.5030.65
217_Y220_T0.5010.64
103_G107_L0.5010.64
373_I416_P0.5000.64
299_A302_P0.5000.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qnqA 2 0.7918 100 0.65 Contact Map
3ipjA 1 0.1918 100 0.798 Contact Map
1ibaA 1 0.1608 100 0.804 Contact Map
3bp3A 1 0.167 100 0.807 Contact Map
4ymuD 2 0.4351 41.2 0.975 Contact Map
4n8nA 1 0.0969 39.3 0.975 Contact Map
2h8eA 2 0.1814 36.2 0.976 Contact Map
4r1iA 2 0.4433 35.9 0.976 Contact Map
4pypA 1 0.6825 34.3 0.976 Contact Map
3b9wA 3 0.6433 33.7 0.976 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0119 seconds.