GREMLIN Database
YEBB - Uncharacterized protein YebB
UniProt: P24238 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11136
Length: 200 (175)
Sequences: 330 (248)
Seq/√Len: 18.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_V76_Y3.7761.00
142_E165_W3.4731.00
53_E62_T3.2691.00
39_G51_V3.1100.99
127_K133_P2.5090.97
138_E174_S2.4730.96
59_S121_F2.3750.96
79_K183_L2.3270.95
38_V122_V2.3130.95
106_H120_K2.2980.95
40_I125_I2.2070.93
111_Y124_D2.1520.92
41_I49_F2.0490.90
53_E79_K2.0280.90
64_L68_I2.0150.90
113_S159_F2.0050.89
109_F158_W1.9720.89
171_T176_W1.9120.87
67_F71_S1.8810.86
59_S120_K1.8410.85
135_G139_T1.8200.84
65_S184_I1.8030.84
31_S80_R1.7890.83
33_C176_W1.7750.83
64_L102_R1.7480.82
31_S171_T1.7430.81
62_T70_R1.7110.80
82_D182_V1.6850.79
155_W169_T1.6390.77
62_T106_H1.6370.77
42_I61_I1.6370.77
24_F27_I1.6190.76
17_T53_E1.6000.75
100_R116_Q1.5880.75
24_F28_S1.5820.74
170_V174_S1.5710.74
82_D179_P1.5670.74
61_I98_P1.5650.74
55_R109_F1.5250.72
135_G171_T1.5100.71
53_E106_H1.4890.70
173_A176_W1.4750.69
108_G154_F1.4520.68
171_T174_S1.4480.68
8_E179_P1.4430.67
113_S124_D1.4140.66
30_A158_W1.3980.65
53_E70_R1.3730.63
65_S69_K1.3640.63
135_G140_F1.3470.62
115_R128_E1.3440.62
43_G49_F1.3400.61
13_D16_F1.3210.60
143_L169_T1.3190.60
28_S154_F1.3030.59
11_I42_I1.2990.59
143_L171_T1.2890.58
81_L178_H1.2860.58
80_R184_I1.2570.56
52_A101_L1.2540.56
44_H61_I1.2450.56
15_V78_I1.2440.55
117_F169_T1.2350.55
116_Q122_V1.2110.53
19_I36_N1.2100.53
155_W164_P1.2100.53
52_A125_I1.2080.53
15_V41_I1.2080.53
37_H118_C1.1860.52
143_L167_R1.1510.50
159_F164_P1.1230.48
138_E175_L1.1170.48
38_V175_L1.1140.47
79_K176_W1.1140.47
41_I88_R1.0860.46
46_G147_N1.0820.45
52_A97_V1.0810.45
134_V178_H1.0740.45
155_W159_F1.0720.45
139_T168_K1.0670.44
10_E90_K1.0670.44
61_I97_V1.0570.44
19_I67_F1.0510.43
135_G169_T1.0240.42
43_G46_G1.0170.41
179_P182_V1.0170.41
158_W163_I1.0140.41
36_N124_D1.0140.41
15_V133_P1.0140.41
26_Q30_A1.0090.41
32_N146_S1.0090.41
14_I163_I0.9960.40
8_E92_R0.9840.39
19_I109_F0.9740.39
30_A170_V0.9740.39
78_I87_E0.9710.39
63_T66_R0.9600.38
36_N119_S0.9570.38
104_L119_S0.9550.38
16_F105_Y0.9470.37
26_Q54_S0.9450.37
78_I94_V0.9130.35
8_E99_S0.9130.35
41_I76_Y0.9040.35
137_I158_W0.9010.35
112_E124_D0.8920.34
170_V175_L0.8880.34
24_F174_S0.8860.34
9_Y14_I0.8850.34
122_V128_E0.8800.33
48_D64_L0.8760.33
135_G173_A0.8750.33
137_I170_V0.8740.33
164_P175_L0.8670.33
52_A121_F0.8660.33
39_G57_P0.8640.32
83_A182_V0.8640.32
55_R159_F0.8580.32
52_A59_S0.8470.32
38_V104_L0.8440.31
67_F154_F0.8400.31
10_E44_H0.8390.31
15_V21_A0.8380.31
79_K106_H0.8370.31
54_S117_F0.8310.31
117_F120_K0.8310.31
36_N123_F0.8300.31
82_D178_H0.8290.31
9_Y12_G0.8270.30
57_P129_A0.8250.30
84_G87_E0.8230.30
61_I101_L0.8230.30
120_K158_W0.8230.30
19_I124_D0.8220.30
36_N113_S0.8160.30
116_Q121_F0.8080.29
95_E179_P0.8010.29
96_Q103_K0.7950.29
104_L139_T0.7940.29
14_I179_P0.7930.29
158_W169_T0.7910.29
15_V61_I0.7850.28
32_N144_L0.7820.28
58_L76_Y0.7810.28
66_R182_V0.7800.28
12_G101_L0.7780.28
45_N87_E0.7720.28
158_W170_V0.7700.28
106_H183_L0.7700.28
52_A81_L0.7630.27
11_I43_G0.7550.27
51_V123_F0.7540.27
91_Q95_E0.7530.27
36_N120_K0.7510.27
35_S77_A0.7500.27
143_L159_F0.7490.26
142_E170_V0.7470.26
111_Y137_I0.7430.26
43_G94_V0.7400.26
40_I122_V0.7350.26
11_I49_F0.7330.26
40_I84_G0.7320.26
66_R179_P0.7320.26
32_N110_K0.7320.26
102_R186_A0.7260.25
121_F126_Y0.7210.25
42_I93_I0.7200.25
51_V82_D0.7180.25
12_G16_F0.7170.25
27_I171_T0.7150.25
151_K165_W0.7120.25
143_L174_S0.7110.25
10_E45_N0.7070.24
23_L111_Y0.7050.24
109_F170_V0.7020.24
78_I83_A0.6980.24
23_L109_F0.6910.24
113_S120_K0.6910.24
65_S94_V0.6820.23
59_S117_F0.6790.23
33_C106_H0.6770.23
46_G87_E0.6700.23
14_I185_H0.6700.23
25_G134_V0.6610.22
91_Q166_E0.6590.22
26_Q121_F0.6550.22
74_Q102_R0.6550.22
139_T171_T0.6490.22
76_Y177_H0.6470.22
14_I95_E0.6430.22
83_A90_K0.6410.22
15_V173_A0.6390.21
51_V175_L0.6390.21
99_S128_E0.6340.21
61_I161_G0.6330.21
104_L125_I0.6280.21
24_F36_N0.6220.21
163_I175_L0.6200.21
40_I128_E0.6170.21
90_K122_V0.6130.20
33_C170_V0.6130.20
74_Q156_K0.6100.20
145_N158_W0.6100.20
30_A142_E0.6090.20
145_N151_K0.6080.20
72_S94_V0.6060.20
28_S36_N0.6050.20
73_N103_K0.6030.20
40_I116_Q0.6010.20
16_F38_V0.5970.20
67_F139_T0.5970.20
42_I98_P0.5970.20
81_L90_K0.5920.20
157_F161_G0.5910.20
117_F143_L0.5850.19
156_K163_I0.5840.19
9_Y13_D0.5820.19
146_S149_N0.5820.19
28_S170_V0.5740.19
97_V125_I0.5740.19
41_I63_T0.5720.19
129_A134_V0.5700.19
109_F129_A0.5690.19
73_N94_V0.5660.19
17_T120_K0.5620.18
14_I29_A0.5620.18
44_H78_I0.5610.18
93_I144_L0.5590.18
9_Y41_I0.5540.18
95_E149_N0.5500.18
30_A174_S0.5480.18
40_I100_R0.5470.18
133_P168_K0.5460.18
29_A91_Q0.5410.18
20_G99_S0.5380.17
155_W163_I0.5360.17
155_W158_W0.5360.17
137_I159_F0.5360.17
26_Q104_L0.5350.17
69_K182_V0.5350.17
27_I134_V0.5310.17
19_I23_L0.5270.17
99_S182_V0.5240.17
144_L150_A0.5240.17
55_R108_G0.5240.17
56_V104_L0.5230.17
87_E180_G0.5210.17
77_A134_V0.5170.17
55_R134_V0.5170.17
51_V58_L0.5150.17
64_L163_I0.5130.17
92_R156_K0.5090.16
52_A126_Y0.5080.16
53_E176_W0.5070.16
27_I135_G0.5060.16
35_S176_W0.5030.16
27_I176_W0.5030.16
139_T185_H0.5030.16
145_N155_W0.5020.16
23_L120_K0.5010.16
26_Q117_F0.5010.16
176_W183_L0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2if6A 1 0.91 100 0.444 Contact Map
3kw0A 3 0.78 100 0.58 Contact Map
4dotA 1 0.495 99.2 0.808 Contact Map
4dpzX 1 0.495 98.7 0.844 Contact Map
2lktA 1 0.515 98.5 0.854 Contact Map
4q95A 3 0.55 98.4 0.857 Contact Map
4q68A 1 0.355 98.1 0.869 Contact Map
2im9A 1 0.435 97.7 0.881 Contact Map
2p1gA 1 0.355 97.7 0.881 Contact Map
4fdyA 1 0.33 97.5 0.884 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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