GREMLIN Database
HMP - Flavohemoprotein
UniProt: P24232 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10456
Length: 396 (352)
Sequences: 5099 (3567)
Seq/√Len: 190.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
344_D377_D3.4571.00
209_T220_A3.4311.00
157_I237_A3.3511.00
160_K168_T3.2461.00
120_W123_A3.2301.00
265_I359_F3.1641.00
238_N241_D3.1561.00
279_D307_E3.1401.00
305_A309_K3.1211.00
103_L113_G3.0301.00
302_H324_Y2.9531.00
123_A127_L2.7421.00
189_L245_L2.6541.00
154_D242_V2.6521.00
105_T109_M2.6221.00
156_R173_E2.5281.00
158_V173_E2.4801.00
308_V320_A2.4721.00
299_G327_P2.4211.00
310_E314_S2.4021.00
107_D113_G2.3251.00
117_L120_W2.3031.00
116_V120_W2.2241.00
190_G205_Q2.2081.00
159_A171_E2.2041.00
263_T357_M2.1721.00
105_T108_E2.1421.00
22_P26_A2.1211.00
328_S331_D2.0991.00
169_S218_R2.0771.00
247_A250_G2.0661.00
343_M378_L2.0371.00
154_D244_K2.0331.00
280_T284_A1.9881.00
171_E218_R1.9841.00
97_I101_H1.9731.00
266_S274_M1.9421.00
299_G305_A1.8841.00
190_G246_V1.8831.00
210_R279_D1.8731.00
127_L135_E1.8691.00
116_V123_A1.8431.00
350_G355_P1.8191.00
343_M348_L1.8131.00
129_N133_N1.7901.00
171_E216_G1.7891.00
331_D337_F1.7861.00
116_V127_L1.7781.00
254_M262_V1.7561.00
192_W244_K1.7551.00
264_L274_M1.7541.00
47_N55_E1.7281.00
70_N73_A1.7131.00
155_F245_L1.7101.00
328_S337_F1.7101.00
345_L382_Q1.6981.00
159_A239_V1.6631.00
351_A357_M1.6611.00
261_P289_Q1.6441.00
341_G344_D1.6381.00
263_T359_F1.6121.00
271_Q308_V1.6061.00
124_Y128_A1.6031.00
116_V119_A1.6011.00
173_E216_G1.5971.00
289_Q355_P1.5801.00
223_R235_N1.5541.00
156_R242_V1.5481.00
237_A241_D1.5441.00
123_A128_A1.5421.00
120_W127_L1.5411.00
262_V290_V1.5381.00
372_A376_V1.5281.00
32_M97_I1.5201.00
291_N321_H1.5171.00
114_Q117_L1.5061.00
157_I172_L1.4901.00
27_H31_R1.4881.00
278_L308_V1.4811.00
114_Q120_W1.4791.00
220_A304_F1.4781.00
293_F343_M1.4661.00
156_R175_V1.4521.00
302_H322_T1.4251.00
349_E379_G1.4211.00
337_F342_L1.4051.00
295_A325_R1.4051.00
359_F375_L1.4041.00
120_W124_Y1.3961.00
117_L123_A1.3811.00
225_E235_N1.3811.00
260_T358_Q1.3761.00
172_L219_I1.3701.00
103_L107_D1.3691.00
70_N98_V1.3681.00
254_M277_M1.3561.00
157_I160_K1.3451.00
315_L318_F1.3291.00
293_F321_H1.3201.00
195_P202_E1.3141.00
350_G354_D1.3031.00
119_A123_A1.3001.00
91_K94_Q1.2951.00
223_R231_N1.2911.00
173_E215_K1.2861.00
302_H309_K1.2861.00
271_Q304_F1.2851.00
118_D121_G1.2821.00
221_V230_S1.2821.00
156_R240_G1.2791.00
297_E325_R1.2781.00
170_F233_L1.2741.00
119_A127_L1.2711.00
275_L307_E1.2701.00
271_Q292_W1.2671.00
167_I269_V1.2641.00
264_L290_V1.2551.00
125_G129_N1.2521.00
167_I303_A1.2521.00
162_P166_L1.2471.00
29_Y41_E1.2471.00
221_V233_L1.2461.00
310_E313_Q1.2461.00
104_A108_E1.2451.00
115_E118_D1.2451.00
158_V216_G1.2341.00
27_H30_D1.2201.00
282_A314_S1.2151.00
155_F172_L1.2091.00
364_P368_M1.2051.00
124_Y127_L1.2051.00
260_T356_T1.2041.00
52_D55_E1.2031.00
295_A343_M1.2011.00
312_G318_F1.2001.00
302_H305_A1.1991.00
195_P198_F1.1961.00
103_L121_G1.1951.00
86_T249_A1.1921.00
115_E123_A1.1891.00
44_N47_N1.1871.00
127_L132_I1.1871.00
327_P331_D1.1791.00
124_Y132_I1.1751.00
155_F174_P1.1741.00
96_N99_G1.1711.00
289_Q319_T1.1661.00
367_F371_T1.1621.00
347_K350_G1.1551.00
291_N348_L1.1501.00
175_V178_G1.1481.00
223_R234_H1.1411.00
373_K377_D1.1321.00
370_F374_Q1.1201.00
115_E120_W1.1201.00
125_G128_A1.0961.00
86_T89_Q1.0921.00
346_S382_Q1.0791.00
127_L139_Y1.0721.00
78_V101_H1.0711.00
267_A367_F1.0711.00
164_S167_I1.0701.00
326_Q338_D1.0691.00
154_D175_V1.0631.00
62_A102_L1.0581.00
169_S304_F1.0411.00
267_A364_P1.0391.00
258_D284_A1.0371.00
55_E58_F1.0361.00
39_L42_I1.0321.00
185_P280_T1.0281.00
302_H320_A1.0261.00
223_R230_S1.0241.00
115_E119_A1.0211.00
282_A311_L1.0161.00
119_A122_K1.0121.00
190_G203_I1.0101.00
118_D122_K1.0091.00
193_L229_V1.0071.00
32_M36_N1.0000.99
174_P217_Y0.9930.99
266_S294_H0.9870.99
341_G370_F0.9860.99
172_L245_L0.9830.99
20_T23_K0.9810.99
117_L121_G0.9740.99
231_N235_N0.9720.99
265_I371_T0.9700.99
128_A135_E0.9680.99
63_A71_L0.9680.99
319_T347_K0.9670.99
29_Y33_F0.9630.99
100_E104_A0.9550.99
172_L243_V0.9530.99
184_R253_F0.9500.99
306_D310_E0.9470.99
60_A102_L0.9440.99
266_S292_W0.9410.99
344_D374_Q0.9330.99
161_T169_S0.9320.99
373_K376_V0.9320.99
211_K280_T0.9310.99
78_V102_L0.9280.99
345_L381_K0.9280.99
63_A77_A0.9270.99
60_A106_L0.9260.99
185_P276_A0.9250.99
347_K351_A0.9240.99
307_E311_L0.9230.99
299_G331_D0.9170.99
127_L131_F0.9170.99
262_V281_L0.9170.99
91_K96_N0.9140.99
35_H101_H0.9090.99
281_L286_H0.9090.99
90_I94_Q0.9050.99
29_Y39_L0.9050.99
296_A301_V0.9010.99
281_L288_A0.8990.99
62_A66_S0.8990.99
232_W244_K0.8950.99
274_M277_M0.8950.99
255_A258_D0.8890.99
214_G279_D0.8850.99
352_F359_F0.8840.99
130_V133_N0.8840.99
291_N319_T0.8810.99
119_A124_Y0.8770.99
232_W237_A0.8770.99
63_A66_S0.8760.99
78_V98_V0.8700.99
309_K312_G0.8650.99
43_F46_S0.8650.99
183_Y210_R0.8640.99
265_I375_L0.8590.98
147_G152_T0.8580.98
279_D311_L0.8580.98
161_T171_E0.8550.98
132_I139_Y0.8550.98
188_Y205_Q0.8520.98
374_Q377_D0.8510.98
186_G207_S0.8490.98
97_I100_E0.8480.98
189_L217_Y0.8430.98
126_V131_F0.8390.98
300_D327_P0.8380.98
79_E134_R0.8370.98
118_D123_A0.8330.98
31_R35_H0.8300.98
365_V368_M0.8260.98
123_A132_I0.8260.98
84_K87_S0.8240.98
124_Y135_E0.8230.98
209_T218_R0.8200.98
120_W128_A0.8170.98
128_A132_I0.8160.98
30_D34_T0.8140.98
247_A251_D0.8110.98
327_P337_F0.8110.98
120_W135_E0.8110.98
267_A274_M0.8090.98
278_L290_V0.8080.98
165_A300_D0.8080.98
307_E310_E0.8070.98
352_F357_M0.8050.98
132_I135_E0.8040.98
346_S350_G0.8010.98
175_V242_V0.8010.98
309_K313_Q0.8000.98
278_L311_L0.7990.98
92_P95_Y0.7970.98
287_T290_V0.7960.97
312_G320_A0.7960.97
160_K170_F0.7960.97
321_H342_L0.7940.97
153_R179_A0.7940.97
263_T291_N0.7930.97
92_P96_N0.7910.97
126_V130_V0.7880.97
117_L127_L0.7880.97
62_A65_A0.7870.97
114_Q123_A0.7840.97
96_N100_E0.7830.97
157_I170_F0.7820.97
376_V382_Q0.7800.97
298_N328_S0.7790.97
78_V105_T0.7780.97
220_A271_Q0.7770.97
213_D280_T0.7770.97
275_L279_D0.7760.97
162_P168_T0.7710.97
298_N327_P0.7700.97
157_I239_V0.7690.97
48_Q51_G0.7670.97
184_R256_V0.7660.97
64_Y68_I0.7650.97
282_A315_L0.7590.97
295_A323_W0.7580.97
169_S220_A0.7540.97
160_K237_A0.7530.96
306_D309_K0.7500.96
309_K322_T0.7470.96
148_G152_T0.7440.96
330_A341_G0.7440.96
36_N39_L0.7420.96
135_E139_Y0.7420.96
207_S276_A0.7390.96
204_R207_S0.7340.96
26_A30_D0.7340.96
128_A131_F0.7330.96
338_D341_G0.7280.96
31_R104_A0.7250.96
152_T246_V0.7250.96
64_Y96_N0.7200.95
205_Q246_V0.7200.95
166_L225_E0.7180.95
80_K84_K0.7170.95
58_F62_A0.7160.95
181_A217_Y0.7150.95
120_W125_G0.7140.95
187_Q253_F0.7130.95
281_L290_V0.7120.95
122_K125_G0.7100.95
370_F373_K0.7090.95
377_D380_V0.7090.95
136_A140_N0.7090.95
275_L304_F0.7080.95
163_R220_A0.7080.95
131_F135_E0.7070.95
349_E352_F0.7060.95
31_R108_E0.7060.95
261_P355_P0.7030.95
123_A139_Y0.7030.95
209_T219_I0.7000.95
22_P25_T0.6980.95
344_D347_K0.6960.95
64_Y127_L0.6950.95
213_D284_A0.6940.95
293_F342_L0.6910.94
64_Y99_G0.6910.94
166_L297_E0.6910.94
189_L208_L0.6900.94
125_G132_I0.6880.94
32_M35_H0.6870.94
104_A107_D0.6870.94
282_A316_P0.6850.94
324_Y327_P0.6850.94
114_Q118_D0.6810.94
127_L130_V0.6810.94
265_I367_F0.6790.94
300_D328_S0.6780.94
47_N50_N0.6770.94
345_L378_L0.6770.94
275_L308_V0.6770.94
129_N132_I0.6770.94
27_H108_E0.6760.94
87_S205_Q0.6750.94
194_K244_K0.6680.93
94_Q97_I0.6680.93
122_K126_V0.6680.93
193_L228_Q0.6680.93
51_G54_R0.6640.93
28_F59_N0.6630.93
78_V82_A0.6600.93
53_Q56_A0.6600.93
135_E138_I0.6580.93
32_M37_P0.6560.93
327_P338_D0.6550.93
116_V121_G0.6530.93
57_L61_I0.6530.93
374_Q378_L0.6480.92
302_H308_V0.6480.92
107_D117_L0.6460.92
25_T36_N0.6450.92
90_I95_Y0.6430.92
28_F32_M0.6410.92
262_V288_A0.6380.92
82_A101_H0.6370.92
116_V128_A0.6370.92
23_K26_A0.6360.92
77_A102_L0.6360.92
45_M73_A0.6360.92
53_Q57_L0.6350.91
264_L288_A0.6340.91
325_R370_F0.6330.91
143_A150_E0.6310.91
22_P55_E0.6310.91
219_I272_T0.6310.91
70_N74_L0.6310.91
325_R338_D0.6300.91
293_F348_L0.6300.91
208_L217_Y0.6270.91
267_A370_F0.6270.91
41_E44_N0.6240.91
160_K238_N0.6230.91
255_A358_Q0.6220.91
321_H339_S0.6210.91
84_K88_F0.6200.90
50_N54_R0.6190.90
121_G125_G0.6190.90
25_T28_F0.6190.90
119_A125_G0.6180.90
163_R169_S0.6170.90
101_H104_A0.6170.90
153_R178_G0.6170.90
136_A150_E0.6160.90
361_L372_A0.6140.90
83_Q86_T0.6140.90
321_H347_K0.6130.90
168_T234_H0.6110.90
325_R342_L0.6100.90
297_E326_Q0.6090.90
254_M258_D0.6080.90
24_L61_I0.6050.89
152_T192_W0.6000.89
376_V379_G0.5990.89
99_G103_L0.5980.89
21_G25_T0.5970.89
161_T306_D0.5970.89
46_S50_N0.5910.88
327_P330_A0.5910.88
106_L111_S0.5900.88
357_M362_C0.5890.88
192_W201_Q0.5880.88
30_D33_F0.5840.88
25_T29_Y0.5830.88
62_A71_L0.5820.88
264_L277_M0.5820.88
327_P340_E0.5810.87
291_N351_A0.5810.87
147_G153_R0.5810.87
116_V132_I0.5780.87
331_D338_D0.5770.87
171_E304_F0.5750.87
126_V129_N0.5750.87
98_V102_L0.5730.87
219_I233_L0.5730.87
322_T338_D0.5730.87
147_G151_G0.5730.87
106_L110_F0.5710.87
26_A54_R0.5700.86
312_G316_P0.5700.86
61_I106_L0.5700.86
33_F39_L0.5690.86
117_L125_G0.5690.86
60_A64_Y0.5670.86
140_N144_S0.5660.86
94_Q99_G0.5660.86
312_G315_L0.5650.86
130_V134_R0.5620.86
294_H303_A0.5610.86
163_R209_T0.5590.85
203_I246_V0.5580.85
345_L351_A0.5570.85
132_I136_A0.5570.85
62_A74_L0.5570.85
293_F323_W0.5560.85
209_T304_F0.5550.85
134_R137_E0.5520.85
297_E338_D0.5520.85
103_L117_L0.5520.85
43_F47_N0.5520.85
308_V311_L0.5500.84
366_G369_Q0.5500.84
257_A260_T0.5470.84
133_N137_E0.5470.84
24_L28_F0.5440.84
304_F307_E0.5440.84
165_A301_V0.5440.84
44_N77_A0.5430.84
168_T223_R0.5430.84
43_F73_A0.5410.83
20_T24_L0.5410.83
278_L282_A0.5410.83
73_A76_P0.5410.83
74_L362_C0.5390.83
184_R280_T0.5350.83
115_E121_G0.5340.83
148_G151_G0.5340.83
312_G319_T0.5330.83
41_E47_N0.5320.82
248_P253_F0.5320.82
119_A135_E0.5310.82
225_E231_N0.5300.82
95_Y119_A0.5300.82
35_H100_E0.5280.82
237_A243_V0.5260.82
128_A137_E0.5260.82
191_V219_I0.5260.82
157_I219_I0.5260.82
340_E343_M0.5210.81
21_G24_L0.5200.81
343_M374_Q0.5200.81
26_A29_Y0.5190.81
134_R138_I0.5170.81
40_K51_G0.5160.81
124_Y131_F0.5160.81
183_Y209_T0.5140.80
210_R213_D0.5140.80
278_L317_R0.5130.80
127_L134_R0.5130.80
85_H88_F0.5130.80
202_E228_Q0.5130.80
74_L77_A0.5120.80
82_A105_T0.5120.80
273_P362_C0.5120.80
167_I222_K0.5120.80
202_E229_V0.5120.80
103_L110_F0.5120.80
311_L315_L0.5110.80
276_A279_D0.5090.80
125_G133_N0.5090.80
155_F180_V0.5070.79
159_A169_S0.5070.79
207_S274_M0.5070.79
258_D358_Q0.5070.79
339_S367_F0.5060.79
23_K27_H0.5060.79
114_Q119_A0.5060.79
309_K320_A0.5050.79
93_E96_N0.5040.79
68_I71_L0.5040.79
348_L351_A0.5030.79
252_F362_C0.5030.79
192_W203_I0.5020.79
261_P357_M0.5020.79
147_G150_E0.5000.78
125_G131_F0.5000.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1tllA 2 0.9646 100 0.331 Contact Map
1gvhA 3 1 100 0.36 Contact Map
2bpoA 1 0.9722 100 0.366 Contact Map
3qe2A 1 0.9697 100 0.367 Contact Map
1cqxA 2 0.9899 100 0.371 Contact Map
4g1vA 3 0.952 100 0.406 Contact Map
1ddgA 1 0.6187 100 0.496 Contact Map
1f20A 1 0.6667 100 0.512 Contact Map
2qtlA 1 0.6414 100 0.526 Contact Map
3qfsA 1 0.6717 100 0.533 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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