GREMLIN Database
DACB - D-alanyl-D-alanine carboxypeptidase DacB
UniProt: P24228 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10202
Length: 477 (438)
Sequences: 1508 (1209)
Seq/√Len: 57.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
63_T428_A5.3621.00
89_K100_D5.1171.00
303_L389_M4.8271.00
37_A367_P4.8231.00
51_D54_S3.9631.00
42_K437_Q3.8841.00
304_K396_D3.7881.00
58_A367_P3.7351.00
37_A58_A3.5691.00
188_A204_V3.3571.00
69_A302_M3.2241.00
119_M288_A3.1841.00
55_Q368_A3.0531.00
43_V440_A2.9941.00
428_A442_V2.9701.00
90_G97_L2.8481.00
82_F317_M2.8471.00
110_T298_L2.8211.00
40_V439_M2.7761.00
315_F332_G2.7361.00
207_L211_S2.6981.00
63_T370_M2.6291.00
69_A303_L2.5351.00
39_M371_M2.5251.00
98_K132_D2.4881.00
168_I313_T2.4881.00
433_T439_M2.4561.00
391_P416_A2.4461.00
63_T442_V2.4221.00
106_G141_I2.4041.00
426_N444_Y2.3621.00
399_L416_A2.3591.00
281_N284_G2.2741.00
134_N272_G2.2731.00
148_A151_W2.1951.00
416_A427_L2.1901.00
88_T287_V2.1571.00
416_A441_F2.1461.00
87_E104_R2.1421.00
370_M444_Y2.1341.00
123_L126_S2.1271.00
371_M440_A2.0951.00
83_T291_Q2.0891.00
374_L430_F2.0541.00
66_V373_V2.0461.00
130_Q271_S2.0001.00
35_N53_H1.9971.00
93_E98_K1.9891.00
171_R307_D1.9751.00
371_M442_V1.9691.00
67_I373_V1.9661.00
414_V441_F1.9541.00
105_F167_A1.9501.00
169_V258_I1.9501.00
367_P444_Y1.9351.00
70_L377_I1.9291.00
100_D133_G1.9291.00
89_K102_V1.8561.00
100_D134_N1.8451.00
69_A299_L1.8391.00
86_L119_M1.8340.99
286_V289_S1.8240.99
402_R460_I1.8150.99
66_V390_L1.7650.99
67_I365_I1.7610.99
432_T438_R1.7540.99
85_T104_R1.7510.99
120_V259_L1.7490.99
90_G99_G1.7410.99
142_F317_M1.7300.99
302_M311_A1.7290.99
115_D290_K1.7210.99
99_G133_G1.7190.99
102_V281_N1.7180.99
53_H56_Q1.7120.99
39_M48_P1.7090.99
392_L396_D1.7000.99
92_V95_G1.6830.99
141_I320_H1.6590.99
120_V266_A1.6520.99
408_A464_R1.6420.99
399_L427_L1.6400.99
375_Q440_A1.6360.99
130_Q269_T1.6320.99
41_Q371_M1.6260.99
86_L123_L1.6200.99
42_K45_A1.6160.99
103_A255_A1.6100.99
168_I309_M1.6030.99
408_A411_D1.5910.99
121_A266_A1.5840.98
124_K129_N1.5820.98
116_I169_V1.5800.98
386_F430_F1.5760.98
180_S206_T1.5760.98
418_T427_L1.5680.98
319_G332_G1.5550.98
92_V97_L1.5480.98
414_V463_V1.5380.98
123_L268_I1.5310.98
128_V287_V1.5260.98
181_A206_T1.5020.98
87_E286_V1.5010.98
103_A135_V1.4980.98
48_P51_D1.4920.98
56_Q367_P1.4910.98
87_E284_G1.4730.98
67_I370_M1.4690.98
443_Q459_R1.4580.97
96_V130_Q1.4550.97
139_T252_A1.4330.97
427_L463_V1.4310.97
181_A186_D1.4260.97
302_M310_I1.4210.97
188_A231_L1.4080.97
151_W355_D1.4060.97
425_Y459_R1.3950.97
315_F356_G1.3930.97
204_V231_L1.3920.97
185_G206_T1.3810.96
83_T289_S1.3570.96
64_Q363_N1.3540.96
263_L268_I1.3540.96
92_V128_V1.3520.96
293_A297_D1.3390.96
414_V431_I1.3340.96
376_Y380_H1.3260.95
383_E387_I1.3070.95
139_T165_A1.3030.95
326_P331_A1.2970.95
75_Q318_I1.2950.95
124_K266_A1.2930.95
374_L428_A1.2910.95
315_F333_S1.2870.95
159_C173_C1.2810.94
123_L128_V1.2740.94
134_N276_R1.2580.94
85_T106_G1.2560.94
378_A438_R1.2550.94
176_V231_L1.2510.94
74_I380_H1.2490.94
387_I415_S1.2450.94
137_I256_G1.2410.94
319_G335_A1.2340.93
413_K432_T1.2310.93
112_K115_D1.2260.93
312_D357_S1.2200.93
377_I382_N1.2170.93
81_R291_Q1.2140.93
150_G362_H1.2010.92
110_T310_I1.1970.92
307_D310_I1.1950.92
301_I305_K1.1880.92
217_C221_V1.1770.92
124_K268_I1.1590.91
43_V378_A1.1570.91
43_V375_Q1.1530.91
63_T426_N1.1370.90
73_L389_M1.1360.90
123_L287_V1.1340.90
42_K47_A1.1310.90
36_L445_L1.1250.90
49_A439_M1.1220.89
75_Q339_I1.1210.89
370_M428_A1.1190.89
96_V99_G1.1160.89
111_L116_I1.1120.89
59_L364_L1.1070.89
138_D141_I1.1070.89
160_F359_L1.1070.89
178_L190_I1.1030.89
35_N447_G1.1030.89
312_D329_W1.1020.89
38_L443_Q1.0920.88
171_R310_I1.0900.88
309_M313_T1.0830.88
138_D142_F1.0830.88
361_R421_L1.0820.88
23_V462_L1.0800.88
315_F336_V1.0790.88
71_A318_I1.0780.88
410_V431_I1.0780.88
303_L390_L1.0770.87
104_R138_D1.0730.87
217_C231_L1.0670.87
250_D253_S1.0670.87
80_F317_M1.0630.87
97_L133_G1.0600.87
41_Q375_Q1.0570.86
460_I463_V1.0530.86
188_A235_L1.0480.86
312_D355_D1.0420.86
151_W359_L1.0420.86
85_T286_V1.0410.86
39_M440_A1.0290.85
67_I353_I1.0210.85
137_I167_A1.0200.84
74_I339_I1.0200.84
420_S425_Y1.0180.84
346_V373_V1.0150.84
73_L78_P1.0140.84
213_E236_P1.0070.84
148_A152_P1.0060.84
97_L128_V1.0050.84
393_A399_L1.0040.84
257_A261_D1.0030.83
99_G128_V1.0020.83
319_G327_G0.9990.83
119_M290_K0.9930.83
132_D271_S0.9900.83
165_A247_A0.9890.83
299_L314_V0.9880.83
72_A76_L0.9810.82
458_R462_L0.9790.82
304_K391_P0.9770.82
22_N465_F0.9750.82
106_G313_T0.9750.82
254_Y258_I0.9730.82
153_W355_D0.9730.82
88_T97_L0.9730.82
119_M123_L0.9660.81
180_S240_E0.9660.81
35_N56_Q0.9630.81
77_G292_S0.9630.81
201_F228_R0.9550.80
430_F446_S0.9540.80
410_V463_V0.9530.80
151_W312_D0.9520.80
390_L399_L0.9500.80
152_P362_H0.9490.80
207_L234_C0.9450.80
175_S245_A0.9450.80
117_R265_Q0.9420.79
319_G331_A0.9350.79
105_F259_L0.9330.79
148_A161_S0.9320.79
172_N383_E0.9290.78
152_P161_S0.9240.78
116_I262_E0.9220.78
148_A153_W0.9210.78
299_L303_L0.9190.78
117_R262_E0.9140.77
20_A24_D0.9110.77
299_L389_M0.9090.77
335_A338_Q0.9090.77
350_N369_T0.9080.77
316_R329_W0.9070.77
154_N354_A0.9040.77
348_I365_I0.9030.76
153_W364_L0.9030.76
164_P313_T0.9000.76
394_G397_G0.8990.76
24_D50_I0.8970.76
333_S353_I0.8950.76
103_A259_L0.8940.76
138_D166_A0.8930.76
316_R327_G0.8930.76
148_A154_N0.8910.75
394_G398_S0.8880.75
207_L236_P0.8870.75
348_I351_T0.8870.75
85_T289_S0.8820.75
134_N273_T0.8820.75
304_K392_L0.8810.75
41_Q440_A0.8790.74
88_T91_N0.8780.74
51_D368_A0.8760.74
90_G102_V0.8720.74
112_K171_R0.8720.74
393_A414_V0.8670.73
62_S65_K0.8670.73
431_I463_V0.8650.73
117_R266_A0.8650.73
176_V229_F0.8640.73
420_S424_V0.8560.73
344_A376_Y0.8550.72
91_N97_L0.8530.72
424_V446_S0.8500.72
48_P52_Y0.8480.72
339_I344_A0.8480.72
86_L128_V0.8450.72
143_A316_R0.8440.71
59_L361_R0.8440.71
168_I172_N0.8430.71
210_G238_R0.8420.71
95_G99_G0.8410.71
366_A369_T0.8380.71
361_R364_L0.8370.71
39_M51_D0.8340.71
357_S363_N0.8310.70
151_W161_S0.8240.70
104_R284_G0.8160.69
59_L446_S0.8150.69
247_A420_S0.8110.68
165_A168_I0.8060.68
371_M375_Q0.8010.67
142_F166_A0.7980.67
86_L259_L0.7980.67
61_A359_L0.7970.67
219_L246_F0.7950.67
370_M442_V0.7950.67
169_V255_A0.7930.67
340_L346_V0.7910.66
97_L100_D0.7870.66
204_V217_C0.7860.66
63_T444_Y0.7860.66
327_G331_A0.7860.66
305_K310_I0.7830.66
102_V280_V0.7820.66
406_H411_D0.7790.65
105_F137_I0.7780.65
427_L441_F0.7770.65
82_F106_G0.7770.65
162_A254_Y0.7760.65
24_D52_Y0.7750.65
355_D363_N0.7750.65
68_T318_I0.7750.65
217_C234_C0.7710.64
221_V229_F0.7680.64
98_K130_Q0.7670.64
35_N58_A0.7660.64
71_A336_V0.7650.64
140_S279_Q0.7650.64
351_T369_T0.7640.64
161_S355_D0.7630.64
401_Y406_H0.7610.63
372_Q375_Q0.7610.63
28_T264_K0.7600.63
230_T346_V0.7590.63
100_D136_L0.7580.63
445_L459_R0.7570.63
68_T315_F0.7550.63
427_L439_M0.7550.63
72_A100_D0.7540.63
171_R305_K0.7480.62
129_N261_D0.7470.62
39_M54_S0.7440.62
91_N95_G0.7430.62
393_A408_A0.7420.61
318_I336_V0.7410.61
80_F106_G0.7410.61
61_A308_N0.7390.61
432_T436_G0.7370.61
26_Y270_W0.7370.61
325_V331_A0.7360.61
391_P399_L0.7340.61
97_L101_L0.7310.60
28_T343_Q0.7310.60
110_T293_A0.7290.60
116_I119_M0.7280.60
402_R427_L0.7260.60
317_M321_A0.7250.60
302_M307_D0.7250.60
381_D384_L0.7230.59
70_L373_V0.7200.59
39_M368_A0.7160.59
107_A142_F0.7150.59
242_L246_F0.7140.59
136_L154_N0.7140.59
122_T288_A0.7110.58
151_W155_D0.7090.58
76_L317_M0.7080.58
163_P249_Q0.7060.58
206_T235_L0.7050.58
394_G411_D0.7040.57
153_W354_A0.7020.57
188_A206_T0.7010.57
427_L431_I0.6990.57
346_V349_G0.6970.57
90_G133_G0.6960.57
327_G332_G0.6960.57
461_P464_R0.6960.57
61_A306_S0.6940.56
229_F247_A0.6930.56
348_I369_T0.6920.56
252_A346_V0.6920.56
155_D161_S0.6920.56
392_L395_Y0.6910.56
179_Y189_F0.6900.56
419_G429_G0.6880.56
126_S287_V0.6870.56
178_L229_F0.6850.55
365_I370_M0.6840.55
340_L402_R0.6820.55
211_S234_C0.6810.55
299_L378_A0.6790.55
316_R332_G0.6780.55
306_S419_G0.6770.55
151_W363_N0.6760.54
415_S420_S0.6760.54
106_G256_G0.6740.54
259_L348_I0.6740.54
262_E265_Q0.6730.54
40_V268_I0.6710.54
304_K418_T0.6700.54
66_V386_F0.6700.54
263_L270_W0.6690.54
161_S247_A0.6690.54
173_C307_D0.6670.53
174_F246_F0.6670.53
49_A85_T0.6670.53
113_R170_D0.6660.53
243_P444_Y0.6650.53
117_R121_A0.6650.53
231_L295_L0.6640.53
118_N121_A0.6640.53
96_V132_D0.6620.53
103_A119_M0.6620.53
131_I201_F0.6610.53
156_M309_M0.6610.53
178_L303_L0.6600.53
150_G153_W0.6590.53
97_L131_I0.6580.52
223_P249_Q0.6570.52
153_W360_S0.6550.52
55_Q278_T0.6550.52
178_L231_L0.6540.52
199_T228_R0.6530.52
73_L386_F0.6520.52
203_Q230_T0.6520.52
42_K49_A0.6500.52
346_V369_T0.6490.51
64_Q353_I0.6470.51
393_A397_G0.6470.51
425_Y443_Q0.6470.51
110_T292_S0.6450.51
334_D338_Q0.6450.51
332_G335_A0.6440.51
75_Q322_R0.6410.51
102_V284_G0.6410.51
77_G108_D0.6400.50
180_S188_A0.6330.50
370_M373_V0.6320.50
306_S417_K0.6300.49
29_Q44_G0.6300.49
461_P465_F0.6280.49
87_E280_V0.6270.49
78_P265_Q0.6270.49
64_Q365_I0.6260.49
201_F230_T0.6250.49
131_I270_W0.6240.49
298_L313_T0.6230.49
126_S129_N0.6230.49
165_A421_L0.6230.49
402_R418_T0.6230.49
202_S205_R0.6220.48
164_P316_R0.6220.48
61_A160_F0.6210.48
66_V428_A0.6200.48
141_I166_A0.6200.48
80_F321_A0.6190.48
203_Q232_T0.6190.48
123_L135_V0.6170.48
87_E103_A0.6170.48
38_L398_S0.6130.47
261_D264_K0.6130.47
58_A444_Y0.6120.47
308_N419_G0.6120.47
42_K435_S0.6110.47
167_A256_G0.6100.47
55_Q366_A0.6090.47
80_F83_T0.6080.47
111_L412_G0.6080.47
335_A339_I0.6070.47
71_A339_I0.6060.47
282_E365_I0.6040.46
174_F229_F0.6040.46
170_D299_L0.6040.46
179_Y191_R0.6030.46
16_F20_A0.6030.46
94_N401_Y0.6030.46
121_A386_F0.6020.46
256_G274_L0.6020.46
39_M367_P0.6020.46
111_L443_Q0.6010.46
294_P297_D0.5990.46
310_I314_V0.5960.46
181_A184_P0.5960.46
202_S446_S0.5940.45
395_Y412_G0.5940.45
308_N417_K0.5930.45
42_K46_S0.5920.45
79_D203_Q0.5920.45
48_P368_A0.5910.45
339_I376_Y0.5910.45
366_A451_E0.5910.45
151_W156_M0.5900.45
166_A272_G0.5900.45
302_M315_F0.5890.45
445_L448_Y0.5890.45
254_Y460_I0.5880.45
184_P206_T0.5880.45
104_R280_V0.5850.44
111_L255_A0.5840.44
114_Q171_R0.5830.44
172_N307_D0.5830.44
416_A463_V0.5820.44
109_P310_I0.5800.44
120_V263_L0.5800.44
158_Q244_L0.5800.44
86_L122_T0.5800.44
70_L386_F0.5800.44
149_P152_P0.5790.44
250_D257_A0.5790.44
200_M353_I0.5780.44
331_A334_D0.5780.44
359_L421_L0.5770.44
178_L204_V0.5770.44
56_Q388_S0.5760.43
73_L385_N0.5760.43
420_S426_N0.5750.43
129_N318_I0.5750.43
317_M320_H0.5740.43
165_A441_F0.5740.43
90_G96_V0.5730.43
385_N389_M0.5730.43
54_S368_A0.5720.43
276_R346_V0.5720.43
318_I332_G0.5690.43
143_A328_T0.5690.43
135_V424_V0.5690.43
152_P361_R0.5680.43
174_F196_Y0.5680.43
399_L418_T0.5660.42
369_T372_Q0.5660.42
82_F168_I0.5640.42
165_A172_N0.5630.42
433_T436_G0.5630.42
431_I439_M0.5620.42
50_I316_R0.5620.42
172_N363_N0.5610.42
311_A357_S0.5600.42
112_K310_I0.5600.42
23_V54_S0.5600.42
159_C171_R0.5600.42
121_A125_K0.5580.41
178_L217_C0.5580.41
99_G136_L0.5570.41
130_Q435_S0.5560.41
385_N415_S0.5560.41
135_V247_A0.5560.41
183_K420_S0.5560.41
198_V202_S0.5550.41
328_T373_V0.5550.41
125_K407_Q0.5550.41
159_C305_K0.5540.41
450_V453_A0.5540.41
189_F279_Q0.5540.41
257_A276_R0.5540.41
459_R462_L0.5530.41
160_F465_F0.5530.41
59_L421_L0.5520.41
410_V413_K0.5500.41
206_T366_A0.5500.41
171_R301_I0.5490.41
448_Y454_D0.5480.40
206_T237_Q0.5480.40
37_A223_P0.5470.40
219_L336_V0.5470.40
174_F249_Q0.5460.40
354_A363_N0.5460.40
81_R134_N0.5460.40
251_G312_D0.5450.40
22_N31_P0.5450.40
312_D348_I0.5450.40
93_E96_V0.5440.40
122_T125_K0.5430.40
416_A443_Q0.5420.40
109_P359_L0.5420.40
296_H299_L0.5420.40
148_A329_W0.5420.40
88_T123_L0.5410.40
411_D464_R0.5410.40
86_L251_G0.5390.39
299_L382_N0.5390.39
70_L376_Y0.5390.39
88_T122_T0.5390.39
312_D316_R0.5380.39
178_L235_L0.5370.39
172_N251_G0.5360.39
296_H385_N0.5350.39
301_I363_N0.5350.39
124_K386_F0.5340.39
19_Q22_N0.5340.39
420_S448_Y0.5340.39
107_A292_S0.5330.39
47_A78_P0.5330.39
339_I380_H0.5330.39
301_I307_D0.5320.39
131_I268_I0.5310.39
113_R169_V0.5310.39
259_L262_E0.5300.39
377_I380_H0.5290.38
101_L131_I0.5290.38
263_L363_N0.5290.38
118_N136_L0.5290.38
398_S402_R0.5290.38
23_V443_Q0.5280.38
120_V268_I0.5280.38
253_S256_G0.5280.38
302_M314_V0.5270.38
332_G357_S0.5270.38
91_N101_L0.5260.38
103_A240_E0.5260.38
297_D300_K0.5260.38
295_L299_L0.5250.38
91_N98_K0.5250.38
304_K402_R0.5240.38
302_M391_P0.5230.38
393_A410_V0.5230.38
57_M366_A0.5220.38
152_P421_L0.5220.38
328_T332_G0.5210.38
36_L120_V0.5200.37
27_I167_A0.5190.37
93_E186_D0.5180.37
173_C245_A0.5180.37
361_R423_G0.5170.37
88_T285_T0.5170.37
111_L463_V0.5160.37
19_Q27_I0.5150.37
82_F298_L0.5140.37
139_T307_D0.5140.37
113_R258_I0.5130.37
139_T166_A0.5120.37
320_H326_P0.5120.37
260_K274_L0.5120.37
95_G187_M0.5120.37
303_L421_L0.5110.37
62_S306_S0.5110.37
367_P377_I0.5110.37
166_A304_K0.5100.36
124_K273_T0.5100.36
47_A437_Q0.5090.36
164_P353_I0.5080.36
319_G402_R0.5080.36
42_K433_T0.5080.36
151_W357_S0.5080.36
421_L424_V0.5080.36
86_L288_A0.5080.36
187_M319_G0.5070.36
389_M446_S0.5060.36
59_L355_D0.5060.36
458_R461_P0.5050.36
107_A293_A0.5050.36
81_R248_V0.5050.36
72_A295_L0.5040.36
151_W360_S0.5040.36
88_T224_G0.5030.36
417_K429_G0.5010.36
357_S421_L0.5010.36
205_R226_L0.5010.36
346_V376_Y0.5010.36
159_C307_D0.5010.36
22_N25_E0.5000.35
44_G190_I0.5000.35
206_T239_S0.5000.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1w5dA 1 0.9308 100 0.257 Contact Map
2ex2A 2 0.956 100 0.267 Contact Map
1w79A 1 0.9455 100 0.272 Contact Map
3a3dA 2 0.9497 100 0.282 Contact Map
3v39A 1 0.7673 100 0.481 Contact Map
4mxgA 1 0.5178 99.9 0.81 Contact Map
3p09A 3 0.5178 99.9 0.812 Contact Map
3dw0A 1 0.5283 99.9 0.818 Contact Map
1bueA 1 0.5178 99.9 0.819 Contact Map
1w7fA 1 0.5115 99.9 0.82 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0122 seconds.