GREMLIN Database
ACPS - Holo-[acyl-carrier-protein] synthase
UniProt: P24224 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10247
Length: 126 (122)
Sequences: 2846 (2057)
Seq/√Len: 186.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
52_K111_L2.7581.00
8_T119_C2.3701.00
6_L121_T2.2921.00
52_K113_D2.2021.00
108_H125_E2.1901.00
82_D86_K2.1701.00
60_A89_L2.1541.00
35_N78_E2.1421.00
96_L100_E2.1261.00
33_S78_E2.1221.00
89_L122_V2.1121.00
112_A119_C2.0781.00
8_T121_T2.0481.00
56_V79_V1.9991.00
56_V109_V1.9461.00
53_R81_N1.9091.00
60_A122_V1.9041.00
12_E116_H1.8461.00
29_R37_W1.8401.00
28_A37_W1.8211.00
107_M124_I1.7771.00
17_E21_A1.6621.00
80_F88_R1.5541.00
10_I117_Y1.5381.00
12_E114_E1.5131.00
99_A104_V1.4901.00
61_A68_I1.4761.00
48_R113_D1.4071.00
39_I81_N1.4051.00
40_W50_L1.3731.00
13_I47_V1.3701.00
55_A120_A1.3471.00
19_V23_S1.3431.00
14_A116_H1.3271.00
68_I74_F1.3151.00
98_L102_L1.2991.00
27_L31_V1.2871.00
80_F90_R1.2791.00
91_L107_M1.2771.00
8_T110_T1.2641.00
77_F89_L1.2611.00
60_A77_F1.2241.00
78_E90_R1.2021.00
25_D29_R1.1981.00
78_E92_W1.1981.00
106_N125_E1.1891.00
41_K50_L1.1801.00
10_I119_C1.1781.00
82_D88_R1.1631.00
17_E47_V1.1541.00
40_W49_F1.1401.00
32_L50_L1.1371.00
35_N38_A1.1331.00
45_Q48_R1.1321.00
94_E97_K1.1241.00
104_V124_I1.1181.00
5_G108_H1.1181.00
11_V118_A1.1071.00
98_L101_K1.1041.00
11_V55_A1.1041.00
11_V16_I1.1031.00
69_R84_L1.1011.00
10_I112_A1.0881.00
19_V27_L1.0691.00
61_A72_L1.0631.00
37_W41_K1.0331.00
13_I118_A1.0191.00
16_I27_L1.0060.99
14_A17_E1.0010.99
60_A64_F1.0000.99
12_E115_R0.9960.99
73_A76_Q0.9900.99
56_V111_L0.9740.99
8_T112_A0.9740.99
32_L49_F0.9710.99
29_R34_D0.9670.99
37_W50_L0.9650.99
20_I28_A0.9550.99
61_A67_G0.9480.99
20_I50_L0.9360.99
76_Q94_E0.9200.99
28_A41_K0.9200.99
17_E45_Q0.9070.99
89_L107_M0.9030.99
91_L95_A0.8960.99
34_D38_A0.8950.99
32_L40_W0.8940.99
35_N80_F0.8720.99
114_E117_Y0.8480.98
49_F53_R0.8430.98
97_K101_K0.8370.98
61_A66_T0.8360.98
79_V109_V0.8240.98
13_I51_A0.8220.98
3_I108_H0.8130.98
20_I47_V0.8110.98
14_A115_R0.8100.98
31_V54_F0.8060.98
41_K46_P0.7970.97
34_D75_N0.7900.97
91_L99_A0.7900.97
4_L104_V0.7760.97
65_G86_K0.7730.97
72_L77_F0.7690.97
63_A124_I0.7610.96
60_A107_M0.7570.96
11_V114_E0.7550.96
23_S26_R0.7540.96
76_Q93_G0.7450.96
13_I114_E0.7330.96
39_I49_F0.7320.96
61_A77_F0.7170.95
15_R30_R0.7160.95
80_F109_V0.7130.95
28_A50_L0.7110.95
32_L39_I0.7080.95
55_A118_A0.7080.95
43_H46_P0.7060.95
60_A91_L0.7040.95
9_D58_E0.7000.94
79_V89_L0.6930.94
46_P50_L0.6880.94
72_L95_A0.6850.94
89_L109_V0.6740.93
86_K108_H0.6710.93
15_R54_F0.6700.93
11_V15_R0.6700.93
9_D62_K0.6690.93
94_E98_L0.6680.93
48_R52_K0.6670.93
90_R96_L0.6640.93
61_A74_F0.6630.93
20_I40_W0.6590.92
3_I125_E0.6560.92
28_A32_L0.6470.92
35_N90_R0.6460.92
72_L94_E0.6460.92
57_K77_F0.6450.92
3_I123_I0.6360.91
25_D37_W0.6310.91
76_Q95_A0.6240.90
19_V22_R0.6200.90
12_E117_Y0.6140.90
108_H121_T0.6130.90
26_R29_R0.6130.90
11_V19_V0.6120.89
49_F52_K0.6080.89
33_S75_N0.6060.89
108_H123_I0.6060.89
97_K100_E0.6050.89
5_G63_A0.6050.89
55_A59_A0.6040.89
93_G96_L0.6040.89
104_V107_M0.6000.89
59_A122_V0.5980.88
76_Q92_W0.5950.88
38_A42_T0.5950.88
40_W53_R0.5940.88
10_I114_E0.5910.88
114_E119_C0.5880.88
6_L110_T0.5830.87
60_A99_A0.5780.87
81_N85_G0.5620.85
64_F72_L0.5610.85
95_A98_L0.5570.85
6_L108_H0.5550.84
64_F98_L0.5460.83
6_L15_R0.5420.83
66_T87_P0.5380.83
12_E15_R0.5350.82
33_S79_V0.5290.81
114_E121_T0.5240.81
43_H49_F0.5230.81
77_F95_A0.5190.80
33_S92_W0.5180.80
54_F86_K0.5150.80
5_G125_E0.5140.80
54_F74_F0.5140.80
66_T72_L0.5040.78
58_E62_K0.5040.78
16_I19_V0.5030.78
25_D41_K0.5030.78
59_A120_A0.5000.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2uv9A 5 0 100 0.12 Contact Map
2uv8A 6 0 100 0.127 Contact Map
2bddA 3 0.8571 100 0.191 Contact Map
2qg8A 3 0.9048 100 0.207 Contact Map
3qmnA 4 1 100 0.232 Contact Map
3nfdA 3 0.9603 100 0.235 Contact Map
2wdsA 3 0.9683 100 0.237 Contact Map
3gwmA 3 0.9603 100 0.267 Contact Map
3hykA 3 0.8889 100 0.323 Contact Map
4jm7A 3 0.9048 100 0.325 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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