GREMLIN Database
INTD - Prophage DLP12 integrase
UniProt: P24218 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10507
Length: 387 (321)
Sequences: 19027 (15972)
Seq/√Len: 891.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
321_A338_G4.7871.00
93_I102_K3.2281.00
224_W263_I3.1061.00
99_S102_K2.9121.00
247_I339_G2.8981.00
312_R315_D2.8171.00
216_K314_H2.6421.00
209_A313_F2.6391.00
320_W337_M2.5671.00
213_G320_W2.5661.00
232_R256_C2.5581.00
204_S262_Q2.3541.00
228_D231_R2.3451.00
318_H351_H2.3241.00
110_M149_H2.2741.00
223_E268_K2.2561.00
37_L40_K2.1971.00
235_W248_G2.1641.00
13_S21_R2.1131.00
60_E87_L2.0861.00
63_C83_I2.0431.00
209_A219_I2.0331.00
107_V150_L2.0141.00
89_H109_R1.9961.00
320_W324_L1.9251.00
31_K35_Q1.9241.00
63_C156_I1.9001.00
233_V248_G1.8831.00
64_L87_L1.8461.00
144_Q148_K1.8391.00
62_A160_A1.8231.00
325_I334_L1.8081.00
15_S21_R1.8001.00
60_E64_L1.7971.00
330_P333_V1.7941.00
256_C260_R1.7801.00
103_I172_V1.7781.00
94_R97_D1.7641.00
62_A95_L1.7601.00
214_L219_I1.7601.00
187_E190_E1.7411.00
340_W346_V1.7341.00
250_A337_M1.7131.00
245_R341_E1.6981.00
224_W270_V1.6891.00
41_R44_E1.6531.00
211_A252_N1.6491.00
159_A164_W1.6421.00
67_L80_K1.6341.00
344_E347_R1.6191.00
204_S261_D1.6141.00
325_I350_A1.6061.00
60_E92_G1.5831.00
40_K44_E1.5831.00
165_K169_K1.5821.00
30_D33_Q1.5661.00
345_M348_R1.5591.00
82_R152_M1.5401.00
13_S23_K1.5391.00
218_N247_I1.5351.00
28_T37_L1.5331.00
232_R253_D1.5261.00
62_A159_A1.5201.00
72_D240_E1.5191.00
75_S79_D1.4991.00
98_I157_L1.4731.00
37_L41_R1.4731.00
216_K220_I1.4651.00
253_D257_K1.4621.00
333_V360_H1.4561.00
203_K207_K1.4451.00
190_E193_R1.4271.00
226_Q237_N1.4111.00
71_A76_L1.3961.00
342_S347_R1.3881.00
228_D233_V1.3831.00
324_L329_V1.3811.00
65_R69_E1.3691.00
150_L154_K1.3651.00
43_A47_R1.3601.00
335_Q346_V1.3541.00
191_A210_L1.3541.00
210_L316_L1.3521.00
67_L76_L1.3381.00
204_S258_V1.3341.00
225_Q268_K1.3241.00
296_K300_L1.3101.00
223_E269_W1.3011.00
199_P203_K1.3001.00
222_L227_I1.3001.00
324_L334_L1.2971.00
329_V363_K1.2911.00
253_D362_R1.2911.00
58_T61_E1.2851.00
205_V219_I1.2771.00
100_E162_R1.2761.00
156_I160_A1.2761.00
338_G346_V1.2751.00
76_L80_K1.2711.00
229_M260_R1.2681.00
321_A334_L1.2651.00
222_L234_A1.2651.00
205_V295_S1.2641.00
332_S335_Q1.2631.00
78_S81_S1.2611.00
191_A323_W1.2541.00
186_L311_F1.2471.00
162_R174_K1.2461.00
326_Q356_H1.2271.00
104_Y108_S1.2251.00
38_H42_K1.2221.00
186_L194_L1.2221.00
161_E167_L1.2141.00
362_R366_D1.2071.00
100_E165_K1.2001.00
202_L298_S1.1941.00
208_F255_A1.1901.00
186_L319_T1.1891.00
93_I97_D1.1881.00
79_D152_M1.1881.00
40_K43_A1.1721.00
193_R197_E1.1671.00
81_S84_E1.1641.00
251_L256_C1.1631.00
39_D46_W1.1551.00
195_I207_K1.1491.00
85_F88_E1.1461.00
226_Q238_P1.1431.00
56_D96_K1.1431.00
251_L255_A1.1341.00
342_S345_M1.1341.00
154_K158_R1.1201.00
214_L236_V1.1181.00
83_I87_L1.1171.00
319_T323_W1.1161.00
188_K323_W1.1151.00
207_K258_V1.1141.00
36_E40_K1.1131.00
254_T365_D1.1131.00
322_S350_A1.1111.00
64_L68_E1.1081.00
262_Q266_H1.1061.00
252_N255_A1.1051.00
329_V360_H1.1031.00
32_R36_E1.1001.00
12_A37_L1.0991.00
332_S336_E1.0971.00
158_R170_A1.0951.00
56_D94_R1.0931.00
35_Q39_D1.0901.00
85_F149_H1.0891.00
44_E49_E1.0871.00
223_E226_Q1.0841.00
106_A149_H1.0791.00
192_K196_D1.0761.00
71_A80_K1.0741.00
72_D75_S1.0641.00
90_F106_A1.0641.00
106_A110_M1.0641.00
335_Q343_I1.0611.00
226_Q240_E1.0571.00
254_T257_K1.0501.00
326_Q353_A1.0491.00
300_L310_D1.0461.00
359_E363_K1.0441.00
299_W303_C1.0391.00
73_K77_D1.0381.00
77_D81_S1.0371.00
197_E305_R1.0361.00
142_S145_T1.0281.00
322_S351_H1.0241.00
157_L167_L1.0201.00
356_H359_E1.0191.00
336_E357_L1.0121.00
205_V271_F1.0031.00
216_K313_F1.0011.00
59_F156_I0.9991.00
208_F219_I0.9901.00
39_D42_K0.9881.00
298_S301_S0.9841.00
185_W319_T0.9781.00
157_L172_V0.9771.00
323_W326_Q0.9771.00
223_E238_P0.9691.00
36_E39_D0.9661.00
9_I25_S0.9621.00
211_A255_A0.9591.00
260_R263_I0.9591.00
207_K254_T0.9531.00
188_K192_K0.9511.00
43_A46_W0.9491.00
16_L22_I0.9441.00
234_A238_P0.9431.00
101_A105_S0.9391.00
60_E91_E0.9351.00
321_A346_V0.9281.00
95_L157_L0.9251.00
64_L80_K0.9241.00
42_K46_W0.9241.00
321_A350_A0.9241.00
198_C206_V0.9231.00
65_R164_W0.9231.00
321_A325_I0.9221.00
335_Q347_R0.9221.00
208_F234_A0.9211.00
148_K151_A0.9201.00
157_L171_P0.9191.00
74_K77_D0.9121.00
26_L37_L0.9111.00
197_E306_A0.9061.00
57_V61_E0.9041.00
11_Y25_S0.9011.00
141_V145_T0.9001.00
252_N365_D0.8981.00
263_I266_H0.8961.00
67_L71_A0.8891.00
199_P207_K0.8881.00
269_W272_V0.8861.00
144_Q147_A0.8851.00
358_T362_R0.8841.00
320_W338_G0.8821.00
241_S246_A0.8781.00
10_W31_K0.8771.00
110_M146_K0.8761.00
65_R166_W0.8741.00
150_L172_V0.8731.00
57_V166_W0.8721.00
161_E169_K0.8701.00
105_S109_R0.8681.00
224_W266_H0.8641.00
337_M357_L0.8631.00
216_K292_R0.8621.00
33_Q37_L0.8601.00
28_T34_A0.8581.00
217_S221_N0.8581.00
33_Q36_E0.8561.00
211_A254_T0.8551.00
99_S165_K0.8521.00
101_A165_K0.8471.00
63_C67_L0.8471.00
329_V333_V0.8461.00
110_M141_V0.8461.00
98_I103_I0.8451.00
73_K76_L0.8451.00
104_Y107_V0.8441.00
59_F63_C0.8431.00
250_A358_T0.8431.00
300_L304_R0.8421.00
57_V65_R0.8391.00
40_K47_R0.8381.00
208_F271_F0.8371.00
141_V146_K0.8361.00
145_T149_H0.8351.00
9_I29_K0.8331.00
103_I153_I0.8321.00
62_A156_I0.8271.00
32_R35_Q0.8271.00
35_Q38_H0.8231.00
327_S363_K0.8191.00
318_H348_R0.8121.00
66_W70_K0.8111.00
34_A38_H0.8091.00
39_D43_A0.8051.00
206_V316_L0.8041.00
89_H105_S0.8041.00
78_S82_R0.8021.00
229_M256_C0.8011.00
59_F153_I0.7991.00
161_E170_A0.7981.00
36_E46_W0.7941.00
220_I292_R0.7931.00
59_F98_I0.7921.00
157_L161_E0.7921.00
198_C203_K0.7891.00
325_I331_L0.7891.00
70_K155_A0.7871.00
333_V356_H0.7871.00
224_W259_L0.7861.00
84_E88_E0.7841.00
86_W153_I0.7791.00
197_E302_A0.7791.00
194_L206_V0.7781.00
89_H106_A0.7761.00
44_E47_R0.7731.00
154_K172_V0.7701.00
342_S346_V0.7691.00
12_A41_R0.7671.00
325_I332_S0.7661.00
62_A166_W0.7651.00
250_A357_L0.7641.00
99_S168_E0.7631.00
66_W155_A0.7611.00
257_K260_R0.7591.00
29_K33_Q0.7591.00
190_E309_E0.7581.00
219_I313_F0.7571.00
222_L270_V0.7551.00
297_T301_S0.7531.00
157_L170_A0.7481.00
12_A38_H0.7471.00
291_M294_D0.7471.00
86_W91_E0.7431.00
183_V312_R0.7421.00
255_A258_V0.7421.00
193_R196_D0.7391.00
48_V51_L0.7391.00
311_F315_D0.7371.00
85_F141_V0.7361.00
354_P357_L0.7341.00
63_C87_L0.7331.00
95_L160_A0.7321.00
36_E43_A0.7321.00
82_R149_H0.7291.00
74_K78_S0.7291.00
210_L319_T0.7281.00
104_Y164_W0.7261.00
343_I347_R0.7241.00
102_K105_S0.7241.00
216_K296_K0.7231.00
294_D297_T0.7231.00
147_A176_P0.7211.00
58_T94_R0.7211.00
194_L299_W0.7201.00
253_D365_D0.7181.00
28_T33_Q0.7171.00
11_Y23_K0.7171.00
69_E108_S0.7161.00
337_M361_A0.7151.00
229_M232_R0.7151.00
302_A306_A0.7151.00
186_L190_E0.7071.00
80_K84_E0.7061.00
61_E64_L0.7051.00
263_I267_H0.7051.00
66_W159_A0.7021.00
332_S347_R0.7011.00
107_V146_K0.7001.00
237_N246_A0.6991.00
212_T249_V0.6991.00
235_W246_A0.6991.00
315_D318_H0.6981.00
353_A356_H0.6971.00
78_S148_K0.6961.00
293_I296_K0.6951.00
355_N359_E0.6941.00
299_W316_L0.6921.00
229_M251_L0.6921.00
229_M234_A0.6901.00
198_C302_A0.6881.00
57_V96_K0.6861.00
293_I297_T0.6831.00
273_H288_V0.6821.00
330_P356_H0.6811.00
296_K313_F0.6771.00
24_E41_R0.6741.00
100_E104_Y0.6701.00
234_A251_L0.6641.00
335_Q345_M0.6631.00
325_I353_A0.6621.00
184_R190_E0.6601.00
210_L323_W0.6571.00
360_H363_K0.6561.00
321_A335_Q0.6541.00
215_R240_E0.6541.00
331_L347_R0.6541.00
70_K79_D0.6491.00
227_I259_L0.6491.00
12_A26_L0.6491.00
331_L343_I0.6481.00
191_A319_T0.6481.00
331_L335_Q0.6451.00
215_R314_H0.6441.00
61_E65_R0.6401.00
160_A167_L0.6381.00
208_F259_L0.6371.00
362_R365_D0.6331.00
214_L222_L0.6331.00
359_E362_R0.6311.00
213_G338_G0.6301.00
294_D298_S0.6281.00
147_A151_A0.6261.00
188_K327_S0.6261.00
104_Y162_R0.6191.00
208_F212_T0.6171.00
269_W289_R0.6161.00
303_C310_D0.6161.00
185_W322_S0.6151.00
65_R105_S0.6141.00
200_E203_K0.6141.00
214_L218_N0.6131.00
90_F102_K0.6091.00
65_R159_A0.6081.00
243_S339_G0.6071.00
83_I156_I0.6071.00
299_W313_F0.6051.00
295_S313_F0.6051.00
66_W79_D0.6051.00
90_F98_I0.6031.00
330_P360_H0.6031.00
233_V358_T0.6031.00
354_P358_T0.6021.00
314_H338_G0.6021.00
60_E83_I0.6001.00
184_R309_E0.5991.00
212_T252_N0.5991.00
86_W106_A0.5971.00
206_V299_W0.5971.00
292_R296_K0.5941.00
227_I234_A0.5901.00
324_L337_M0.5891.00
326_Q355_N0.5891.00
355_N358_T0.5891.00
155_A159_A0.5861.00
167_L171_P0.5831.00
68_E71_A0.5821.00
335_Q338_G0.5781.00
258_V261_D0.5771.00
106_A153_I0.5771.00
189_E193_R0.5771.00
156_I159_A0.5761.00
12_A45_L0.5761.00
195_I211_A0.5761.00
343_I346_V0.5761.00
195_I203_K0.5721.00
85_F140_P0.5701.00
207_K211_A0.5671.00
79_D82_R0.5661.00
275_K288_V0.5651.00
158_R161_E0.5641.00
65_R68_E0.5641.00
141_V149_H0.5621.00
143_T147_A0.5601.00
45_L50_K0.5601.00
208_F214_L0.5591.00
257_K261_D0.5591.00
12_A42_K0.5581.00
82_R148_K0.5571.00
212_T255_A0.5541.00
260_R264_G0.5541.00
236_V241_S0.5511.00
300_L303_C0.5501.00
101_A164_W0.5481.00
230_Q260_R0.5481.00
158_R162_R0.5471.00
326_Q352_L0.5471.00
214_L234_A0.5461.00
214_L249_V0.5421.00
106_A109_R0.5421.00
203_K258_V0.5411.00
188_K326_Q0.5401.00
153_I172_V0.5401.00
212_T219_I0.5391.00
297_T300_L0.5381.00
241_S247_I0.5371.00
228_D235_W0.5371.00
75_S78_S0.5371.00
209_A295_S0.5331.00
195_I199_P0.5321.00
325_I330_P0.5311.00
352_L356_H0.5301.00
154_K170_A0.5301.00
328_G356_H0.5281.00
14_Y22_I0.5271.00
173_I176_P0.5241.00
87_L91_E0.5231.00
261_D264_G0.5231.00
85_F110_M0.5211.00
26_L41_R0.5211.00
64_L83_I0.5161.00
324_L360_H0.5161.00
228_D232_R0.5151.00
190_E311_F0.5151.00
329_V334_L0.5121.00
331_L346_V0.5111.00
69_E159_A0.5111.00
301_S305_R0.5081.00
69_E104_Y0.5081.00
321_A340_W0.5081.00
331_L350_A0.5021.00
248_G354_P0.5011.00
241_S339_G0.5001.00
189_E192_K0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1z1bA 3 0.814 100 0.33 Contact Map
2a3vA 3 0.7287 100 0.365 Contact Map
1a0pA 1 0.6357 100 0.377 Contact Map
1z19A 3 0.6796 100 0.391 Contact Map
4a8eA 2 0.6667 100 0.422 Contact Map
1xo0A 3 0.7261 100 0.428 Contact Map
3nkhA 2 0.4651 100 0.522 Contact Map
1ae9A 4 0.4057 100 0.578 Contact Map
1aihA 2 0.4212 100 0.606 Contact Map
4e0gA 2 0.6486 99.9 0.633 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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