GREMLIN Database
FLID - Flagellar hook-associated protein 2
UniProt: P24216 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10841
Length: 468 (435)
Sequences: 2072 (1705)
Seq/√Len: 81.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
224_N235_E5.5711.00
101_H226_Q4.9671.00
14_D17_S4.7161.00
101_H223_Q4.3101.00
226_Q233_A3.3121.00
357_L362_L3.1311.00
276_K280_N3.1071.00
98_S228_T2.9551.00
272_Q363_T2.9501.00
369_D372_G2.9401.00
107_T230_N2.8911.00
148_S156_A2.8821.00
349_D352_D2.8701.00
349_D356_E2.8701.00
148_S152_G2.7811.00
287_D354_K2.7591.00
227_L241_I2.6961.00
364_A368_K2.6831.00
226_Q235_E2.6531.00
224_N237_S2.6421.00
57_F285_L2.6321.00
15_L19_L2.6291.00
349_D354_K2.6241.00
17_S21_S2.6011.00
276_K359_A2.5441.00
273_T277_D2.5151.00
100_T226_Q2.5131.00
154_R168_I2.4731.00
157_I180_V2.4631.00
236_N243_D2.4111.00
104_Q223_Q2.3481.00
144_S147_N2.3141.00
344_I376_L2.2571.00
228_T233_A2.2371.00
60_A281_A2.2151.00
97_I229_V2.2111.00
358_D361_K2.1851.00
241_I252_L2.1791.00
435_R439_Q2.1741.00
100_T228_T2.0831.00
82_F262_L2.0821.00
82_F97_I2.0301.00
81_A256_T2.0021.00
433_V437_K2.0021.00
157_I166_A2.0011.00
94_K263_T1.9641.00
276_K357_L1.9561.00
165_S183_N1.9481.00
240_T251_N1.9241.00
100_T233_A1.9191.00
27_K426_S1.9191.00
23_T429_I1.9171.00
21_S24_A1.9171.00
98_S258_G1.9131.00
436_Y440_F1.9121.00
275_I357_L1.8821.00
127_K140_T1.8811.00
275_I362_L1.8431.00
147_N152_G1.8301.00
362_L366_L1.8241.00
456_Y460_Q1.8091.00
77_S260_Q1.7851.00
432_Q435_R1.7641.00
432_Q436_Y1.7611.00
426_S430_D1.7511.00
241_I250_L1.7481.00
348_T355_L1.7261.00
7_L15_L1.6991.00
98_S259_N1.6951.00
171_V177_R1.6951.00
78_S81_A1.6821.00
443_L447_M1.6711.00
202_Q205_M1.6691.00
16_S437_K1.6671.00
272_Q359_A1.6421.00
256_T259_N1.6391.00
53_A288_T1.6361.00
280_N284_S1.6311.00
82_F260_Q1.6271.00
227_L234_I1.6151.00
339_K343_Q1.6011.00
13_L443_L1.5991.00
152_G156_A1.5981.00
33_I418_L1.5921.00
310_G313_L1.5841.00
256_T260_Q1.5811.00
279_V357_L1.5711.00
31_T35_N1.5661.00
269_S273_T1.5621.00
84_A262_L1.5611.00
23_T432_Q1.5491.00
144_S148_S1.5441.00
129_T140_T1.5431.00
441_T445_V1.5401.00
37_Q419_T1.5150.99
45_S48_G1.4980.99
95_Y230_N1.4840.99
102_L252_L1.4810.99
44_L411_V1.4770.99
430_D434_A1.4650.99
438_E442_Q1.4640.99
139_I162_A1.4620.99
288_T292_L1.4610.99
128_L133_G1.4610.99
155_D159_N1.4600.99
26_Q432_Q1.4500.99
227_L252_L1.4480.99
295_Y307_S1.4440.99
106_Q191_M1.4430.99
189_N222_A1.4420.99
287_D291_S1.4370.99
424_A427_D1.4350.99
376_L386_I1.4300.99
128_L132_Q1.4150.99
105_A185_T1.3950.99
456_Y459_Q1.3790.99
78_S254_D1.3610.99
40_F411_V1.3550.99
19_L23_T1.3530.99
366_L373_V1.3460.99
127_K142_D1.3410.99
190_A222_A1.3400.99
223_Q226_Q1.3400.99
236_N241_I1.3380.99
188_D224_N1.3380.99
97_I262_L1.3370.99
371_S375_A1.3340.99
274_A277_D1.3310.99
425_A429_I1.3100.98
218_V221_A1.3090.98
419_T423_N1.3080.98
96_T259_N1.3070.98
25_A28_A1.3030.98
37_Q422_Y1.2820.98
20_D24_A1.2740.98
22_L440_F1.2700.98
44_L48_G1.2700.98
34_S37_Q1.2700.98
269_S363_T1.2680.98
82_F250_L1.2650.98
296_T306_S1.2630.98
296_T307_S1.2510.98
84_A250_L1.2500.98
279_V355_L1.2350.98
420_K424_A1.2340.98
268_T367_K1.2280.98
51_K55_T1.2230.97
154_R178_L1.2150.97
229_V234_I1.2110.97
227_L233_A1.2080.97
151_S155_D1.2070.97
225_A239_N1.2050.97
98_S256_T1.2020.97
8_G12_G1.2000.97
83_S251_N1.1920.97
33_I422_Y1.1910.97
27_K429_I1.1850.97
340_T343_Q1.1790.97
275_I377_I1.1760.97
443_L450_L1.1670.97
102_L255_V1.1620.97
46_A292_L1.1500.96
44_L412_S1.1450.96
170_N176_Y1.1410.96
295_Y313_L1.1400.96
110_T113_T1.1360.96
271_A366_L1.1340.96
180_V193_L1.1140.96
328_M393_N1.0980.95
277_D280_N1.0980.95
60_A63_A1.0980.95
227_L236_N1.0920.95
10_G444_D1.0890.95
131_Q192_T1.0830.95
15_L443_L1.0830.95
272_Q357_L1.0830.95
69_L274_A1.0830.95
143_I153_I1.0830.95
363_T367_K1.0820.95
131_Q138_P1.0790.95
129_T138_P1.0780.95
329_L355_L1.0780.95
53_A284_S1.0780.95
225_A252_L1.0770.95
81_A254_D1.0760.95
306_S309_N1.0730.95
187_L224_N1.0720.95
29_T425_A1.0710.94
31_T34_S1.0690.94
7_L10_G1.0660.94
412_S416_N1.0660.94
34_S422_Y1.0640.94
38_S42_A1.0630.94
458_T462_E1.0620.94
405_K409_D1.0600.94
344_I373_V1.0560.94
225_A236_N1.0530.94
19_L433_V1.0490.94
399_S405_K1.0480.94
16_S20_D1.0440.94
61_N390_I1.0400.94
96_T261_T1.0390.94
324_Q393_N1.0370.93
6_S10_G1.0370.93
225_A241_I1.0330.93
50_L292_L1.0330.93
23_T27_K1.0310.93
54_L394_L1.0230.93
427_D431_A1.0210.93
150_L168_I1.0180.93
286_I322_Q1.0160.93
315_D407_A1.0090.93
227_L250_L1.0070.92
8_G444_D1.0050.92
434_A438_E1.0050.92
416_N420_K1.0050.92
75_T84_A1.0030.92
417_K421_D1.0030.92
273_T276_K1.0010.92
23_T433_V1.0000.92
28_A31_T0.9990.92
322_Q326_K0.9950.92
270_K273_T0.9950.92
154_R158_N0.9920.92
33_I425_A0.9890.92
149_S153_I0.9870.92
63_A277_D0.9860.92
108_L191_M0.9820.91
293_T318_L0.9740.91
168_I176_Y0.9740.91
80_T254_D0.9570.90
392_S395_T0.9540.90
187_L237_S0.9520.90
84_A248_I0.9510.90
271_A274_A0.9510.90
60_A277_D0.9490.90
40_F415_L0.9470.90
166_A180_V0.9450.90
131_Q134_G0.9440.90
436_Y439_Q0.9440.90
149_S152_G0.9430.90
40_F414_T0.9430.90
229_V244_A0.9420.90
164_V180_V0.9380.90
44_L415_L0.9370.89
430_D433_V0.9360.89
153_I205_M0.9320.89
94_K261_T0.9260.89
29_T32_P0.9250.89
365_A368_K0.9230.89
361_K364_A0.9220.89
145_A148_S0.9220.89
420_K423_N0.9210.89
245_L248_I0.9150.88
48_G51_K0.9110.88
143_I148_S0.9110.88
422_Y444_D0.9100.88
106_Q222_A0.9090.88
288_T291_S0.9070.88
143_I201_L0.9060.88
163_G183_N0.8920.87
255_V259_N0.8920.87
272_Q276_K0.8900.87
62_T66_K0.8880.87
65_S391_G0.8870.87
30_L426_S0.8830.86
168_I178_L0.8820.86
29_T428_R0.8810.86
184_D189_N0.8780.86
55_T58_Q0.8760.86
286_I290_S0.8740.86
271_A370_A0.8720.86
321_I397_W0.8710.86
284_S288_T0.8700.86
39_S43_K0.8700.86
106_Q190_A0.8700.86
346_I355_L0.8700.86
76_T265_T0.8610.85
73_T86_T0.8580.85
107_T181_T0.8560.85
72_A270_K0.8540.85
36_Q421_D0.8520.84
107_T179_S0.8520.84
83_S253_N0.8520.84
78_S245_L0.8510.84
101_H187_L0.8500.84
8_G11_S0.8500.84
328_M389_T0.8470.84
53_A285_L0.8420.84
50_L321_I0.8390.84
27_K425_A0.8390.84
185_T237_S0.8360.83
289_F292_L0.8360.83
267_D270_K0.8250.83
367_K370_A0.8230.82
275_I346_I0.8230.82
40_F44_L0.8190.82
236_N252_L0.8170.82
26_Q29_T0.8160.82
289_F318_L0.8110.81
126_S133_G0.8080.81
188_D237_S0.8080.81
22_L26_Q0.8050.81
153_I157_I0.8050.81
422_Y426_S0.8050.81
56_T281_A0.8030.81
63_A66_K0.8020.81
23_T30_L0.8020.81
296_T313_L0.8010.81
447_M451_N0.8000.81
347_T358_D0.7990.80
429_I433_V0.7960.80
7_L16_S0.7960.80
27_K433_V0.7960.80
11_S444_D0.7950.80
457_L460_Q0.7940.80
255_V260_Q0.7910.80
19_L441_T0.7890.80
408_T412_S0.7870.79
203_S208_D0.7860.79
172_G176_Y0.7850.79
82_F99_V0.7840.79
410_G414_T0.7840.79
440_F443_L0.7760.78
50_L318_L0.7740.78
338_Y369_D0.7730.78
73_T92_A0.7720.78
115_D119_T0.7720.78
255_V258_G0.7720.78
35_N39_S0.7710.78
185_T224_N0.7710.78
37_Q415_L0.7710.78
106_Q218_V0.7700.78
424_A428_R0.7700.78
98_S257_T0.7690.78
139_I161_K0.7690.78
17_S20_D0.7670.78
282_Y286_I0.7660.78
200_A203_S0.7630.77
375_A379_G0.7620.77
451_N455_S0.7550.77
359_A363_T0.7550.77
281_A284_S0.7530.76
455_S458_T0.7500.76
120_A149_S0.7480.76
130_I193_L0.7470.76
30_L425_A0.7470.76
446_L450_L0.7470.76
401_T405_K0.7450.76
187_L235_E0.7450.76
33_I37_Q0.7440.76
338_Y376_L0.7420.75
15_L444_D0.7420.75
241_I244_A0.7370.75
202_Q206_G0.7360.75
427_D430_D0.7330.74
12_G444_D0.7320.74
341_L346_I0.7300.74
126_S130_I0.7280.74
227_L244_A0.7280.74
428_R432_Q0.7280.74
289_F322_Q0.7260.74
34_S38_S0.7260.74
20_D433_V0.7230.73
54_L285_L0.7230.73
271_A357_L0.7210.73
346_I377_I0.7180.73
338_Y344_I0.7170.73
234_I244_A0.7140.73
29_T33_I0.7140.73
273_T280_N0.7140.73
344_I361_K0.7130.72
106_Q182_S0.7130.72
192_T195_V0.7120.72
74_S269_S0.7100.72
203_S207_Y0.7100.72
77_S81_A0.7080.72
97_I227_L0.7080.72
397_W403_I0.7080.72
104_Q220_V0.7080.72
319_R323_T0.7070.72
436_Y441_T0.7070.72
395_T399_S0.7070.72
58_Q391_G0.7050.72
406_A409_D0.7000.71
154_R166_A0.7000.71
453_T456_Y0.6990.71
279_V362_L0.6970.71
109_T177_R0.6960.71
22_L436_Y0.6950.70
201_L204_F0.6950.70
266_Q271_A0.6950.70
85_T249_T0.6940.70
141_I162_A0.6920.70
415_L419_T0.6910.70
145_A198_D0.6910.70
170_N173_N0.6900.70
158_N164_V0.6890.70
333_V376_L0.6870.70
7_L437_K0.6850.69
147_N156_A0.6850.69
326_K348_T0.6850.69
293_T313_L0.6840.69
236_N314_G0.6830.69
123_T147_N0.6810.69
62_T391_G0.6800.69
95_Y264_I0.6780.69
349_D355_L0.6780.69
236_N242_S0.6780.69
141_I160_A0.6770.68
418_L425_A0.6770.68
325_L390_I0.6740.68
148_S153_I0.6710.68
157_I164_V0.6700.68
364_A367_K0.6680.67
201_L206_G0.6670.67
151_S168_I0.6660.67
418_L422_Y0.6660.67
59_T63_A0.6660.67
285_L289_F0.6650.67
101_H235_E0.6620.67
184_D238_S0.6610.67
110_T177_R0.6610.67
115_D118_K0.6610.67
147_N318_L0.6600.67
321_I343_Q0.6590.66
92_A266_Q0.6590.66
185_T293_T0.6570.66
344_I365_A0.6550.66
74_S265_T0.6550.66
201_L208_D0.6520.66
10_G15_L0.6510.65
338_Y343_Q0.6510.65
122_A148_S0.6500.65
327_S330_S0.6500.65
21_S440_F0.6490.65
242_S249_T0.6480.65
360_D364_A0.6480.65
442_Q446_L0.6470.65
437_K441_T0.6450.65
203_S206_G0.6440.65
413_K416_N0.6440.65
101_H255_V0.6420.64
202_Q207_Y0.6420.64
280_N354_K0.6410.64
19_L429_I0.6400.64
425_A428_R0.6390.64
278_W341_L0.6380.64
158_N166_A0.6370.64
241_I251_N0.6370.64
79_T82_F0.6370.64
182_S191_M0.6360.64
451_N454_S0.6350.64
74_S267_D0.6330.63
352_D356_E0.6330.63
119_T123_T0.6330.63
100_T255_V0.6320.63
73_T346_I0.6310.63
450_L454_S0.6290.63
282_Y355_L0.6280.63
8_G19_L0.6270.63
49_T292_L0.6270.63
10_G48_G0.6250.62
105_A181_T0.6230.62
50_L289_F0.6230.62
290_S354_K0.6230.62
46_A311_A0.6230.62
108_L218_V0.6230.62
295_Y306_S0.6230.62
70_F378_V0.6220.62
296_T305_Q0.6220.62
38_S41_T0.6220.62
236_N244_A0.6210.62
122_A126_S0.6210.62
122_A195_V0.6200.62
16_S433_V0.6200.62
372_G375_A0.6160.61
327_S331_N0.6160.61
21_S25_A0.6160.61
305_Q327_S0.6100.60
295_Y308_S0.6100.60
19_L436_Y0.6090.60
365_A373_V0.6080.60
295_Y309_N0.6050.60
69_L72_A0.6040.60
396_S399_S0.6030.60
330_S447_M0.6020.59
335_S339_K0.6020.59
158_N165_S0.6020.59
119_T149_S0.6000.59
41_T415_L0.6000.59
439_Q442_Q0.6000.59
361_K365_A0.5990.59
402_G407_A0.5990.59
118_K151_S0.5990.59
90_A93_G0.5990.59
326_K342_A0.5960.59
37_Q418_L0.5960.59
380_D385_G0.5950.59
281_A286_I0.5930.58
11_S443_L0.5920.58
332_T389_T0.5920.58
291_S294_K0.5920.58
79_T83_S0.5880.58
24_A28_A0.5870.58
81_A255_V0.5860.57
189_N237_S0.5840.57
169_I179_S0.5840.57
372_G376_L0.5840.57
359_A367_K0.5830.57
57_F281_A0.5830.57
33_I40_F0.5800.57
90_A248_I0.5790.57
50_L90_A0.5780.56
27_K30_L0.5780.56
454_S458_T0.5770.56
394_L398_L0.5770.56
422_Y425_A0.5760.56
97_I241_I0.5750.56
391_G395_T0.5750.56
284_S287_D0.5750.56
37_Q41_T0.5740.56
101_H233_A0.5730.56
6_S15_L0.5730.56
194_S197_G0.5730.56
59_T242_S0.5720.56
443_L446_L0.5720.56
167_S246_E0.5710.55
131_Q194_S0.5710.55
68_D159_N0.5670.55
278_W355_L0.5650.55
241_I249_T0.5650.55
45_S49_T0.5640.55
104_Q255_V0.5620.54
297_A311_A0.5620.54
329_L347_T0.5620.54
97_I252_L0.5620.54
97_I250_L0.5620.54
13_L18_I0.5610.54
450_L453_T0.5600.54
86_T89_N0.5590.54
53_A57_F0.5590.54
123_T152_G0.5570.54
231_N236_N0.5570.54
106_Q188_D0.5570.54
279_V353_G0.5560.54
6_S9_V0.5560.54
127_K130_I0.5550.53
356_E360_D0.5520.53
423_N426_S0.5500.53
403_I407_A0.5500.53
62_T65_S0.5500.53
51_K405_K0.5480.52
289_F321_I0.5480.52
89_N92_A0.5480.52
338_Y365_A0.5470.52
15_L437_K0.5470.52
127_K133_G0.5470.52
78_S253_N0.5470.52
63_A274_A0.5450.52
269_S272_Q0.5450.52
6_S18_I0.5440.52
155_D168_I0.5440.52
75_T86_T0.5440.52
296_T309_N0.5440.52
436_Y443_L0.5440.52
49_T288_T0.5430.52
129_T132_Q0.5430.52
443_L460_Q0.5420.52
14_D18_I0.5410.52
389_T393_N0.5410.52
15_L456_Y0.5410.52
134_G371_S0.5390.51
21_S26_Q0.5390.51
126_S143_I0.5390.51
295_Y314_G0.5390.51
55_T59_T0.5380.51
47_Y315_D0.5380.51
409_D413_K0.5370.51
55_T398_L0.5370.51
144_S152_G0.5370.51
42_A45_S0.5370.51
307_S313_L0.5370.51
57_F386_I0.5360.51
167_S228_T0.5360.51
48_G52_S0.5360.51
113_T121_I0.5350.51
105_A220_V0.5350.51
429_I432_Q0.5350.51
419_T422_Y0.5350.51
275_I385_G0.5340.51
431_A435_R0.5340.51
18_I436_Y0.5340.51
95_Y250_L0.5340.51
240_T249_T0.5320.50
198_D205_M0.5320.50
128_L193_L0.5320.50
399_S443_L0.5310.50
180_V191_M0.5310.50
120_A147_N0.5300.50
18_I25_A0.5300.50
347_T361_K0.5300.50
129_T196_S0.5280.50
32_P433_V0.5280.50
23_T426_S0.5280.50
440_F461_F0.5250.49
21_S27_K0.5250.49
128_L195_V0.5250.49
357_L366_L0.5240.49
138_P165_S0.5240.49
44_L47_Y0.5230.49
333_V386_I0.5230.49
447_M450_L0.5220.49
244_A250_L0.5210.49
99_V255_V0.5200.49
61_N278_W0.5200.49
57_F61_N0.5190.49
61_N395_T0.5190.49
268_T363_T0.5180.49
417_K420_K0.5160.48
171_V236_N0.5150.48
377_I387_T0.5140.48
100_T227_L0.5140.48
309_N313_L0.5140.48
66_K275_I0.5130.48
90_A264_I0.5130.48
144_S156_A0.5110.48
377_I385_G0.5110.48
24_A27_K0.5110.48
102_L193_L0.5110.48
114_R119_T0.5100.47
72_A274_A0.5090.47
293_T314_G0.5090.47
47_Y317_T0.5080.47
46_A50_L0.5080.47
249_T389_T0.5070.47
23_T29_T0.5070.47
102_L271_A0.5050.47
347_T379_G0.5050.47
293_T319_R0.5040.47
384_T392_S0.5040.47
297_A307_S0.5040.47
336_S372_G0.5030.47
150_L154_R0.5030.47
386_I445_V0.5030.47
30_L422_Y0.5030.47
397_W400_T0.5030.47
16_S19_L0.5020.46
331_N394_L0.5020.46
347_T356_E0.5010.46
190_A193_L0.5010.46
51_K398_L0.5000.46
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1deqA 1 0.2585 56.3 0.965 Contact Map
3c9iA 5 0.3056 52.4 0.966 Contact Map
4cgkA 3 0.188 51.3 0.966 Contact Map
3ghgA 2 0.2799 49.2 0.966 Contact Map
4linA 5 0.3376 48.2 0.967 Contact Map
3swyA 3 0.0983 46.5 0.967 Contact Map
3tnuB 1 0.1389 39.1 0.968 Contact Map
3tnuA 2 0.1282 39 0.968 Contact Map
2z5iA 3 0.1068 38.1 0.968 Contact Map
4ll8A 1 0 35.3 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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