UXUA - ECOLI - GREMLIN Contacts

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UXUA - Mannonate dehydratase

UniProt:	P24215	Sequences: MEQTWRWYGPNDPVSLADVRQAGATGVVTALHHIPNGEVWSVEEILKRKAIIEDAGLVWSVVESVPIHEDIKTHTGNYEQWIANYQQTLRNLAQCGIRTVCYNFMPVLDWTRTDLEYVLPDGSKALRFDQIEFAAFEMHILKRPGAEADYTEEEIAQAAERFATMSDEDKARLTRNIIAGLPGAEEGYTLDQFRKHLELYKDIDKAKLRENFAVFLKAIIPVAEEVGVRMAVHPDDPPRPILGLPRIVSTIEDMQWMVDTVNSMANGFTMCTGSYGVRADNDLVDMIKQFGPRIYFTHLRSTMREDNPKTFHEAAHLNGDVDMYEVVKAIVEEEHRRKAEGKEDLIPMRPDHGHQMLDDLKKKTNPGYSAIGRLKGLAEVRGVELAIQRAFFSR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11066
Length:	394 (385)
Sequences:	570 (366)
Seq/√Len:	18.7

ECOLI - UXUA
BACSU - UXUA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
33_H	44_E	3.945	1.00
65_V	88_T	3.856	1.00
220_I	230_M	3.807	1.00
224_E	263_S	3.738	1.00
212_F	232_V	3.624	1.00
42_V	95_C	3.601	1.00
272_T	326_V	3.587	1.00
90_R	225_E	3.524	1.00
297_T	330_I	3.456	1.00
204_D	207_K	3.335	1.00
89_L	100_V	3.306	1.00
44_E	47_K	3.082	0.99
251_I	289_Q	3.017	0.99
93_A	226_V	2.949	0.99
254_M	275_Y	2.810	0.98
255_Q	289_Q	2.784	0.98
251_I	285_D	2.769	0.98
194_R	198_E	2.659	0.98
89_L	228_V	2.632	0.98
132_E	161_R	2.619	0.97
383_V	386_A	2.612	0.97
159_A	163_A	2.563	0.97
4_T	26_G	2.440	0.96
2_E	60_S	2.438	0.96
86_Q	218_A	2.383	0.96
49_K	53_E	2.257	0.94
220_I	263_S	2.253	0.94
251_I	290_F	2.249	0.94
65_V	89_L	2.223	0.94
68_H	81_W	2.221	0.93
315_A	318_N	2.196	0.93
284_V	325_E	2.186	0.93
285_D	289_Q	2.162	0.93
231_A	269_T	2.161	0.93
324_Y	386_A	2.156	0.92
138_M	155_I	2.139	0.92
34_I	41_S	2.132	0.92
209_R	256_W	2.121	0.92
101_C	269_T	2.095	0.91
287_I	291_G	2.093	0.91
83_A	86_Q	2.059	0.91
198_E	201_K	2.043	0.90
357_L	370_A	2.031	0.90
287_I	294_I	2.006	0.89
62_V	92_L	2.000	0.89
327_V	383_V	1.973	0.89
3_Q	384_E	1.954	0.88
275_Y	286_M	1.939	0.88
250_T	278_R	1.900	0.87
33_H	47_K	1.900	0.87
277_V	302_T	1.898	0.86
139_H	159_A	1.896	0.86
303_M	320_D	1.881	0.86
123_S	356_M	1.874	0.86
254_M	268_F	1.863	0.85
282_D	285_D	1.863	0.85
371_I	374_L	1.849	0.85
161_R	165_M	1.830	0.84
29_T	52_I	1.830	0.84
100_V	228_V	1.824	0.84
331_V	387_I	1.822	0.84
285_D	290_F	1.808	0.84
118_V	124_K	1.806	0.84
121_D	375_K	1.767	0.82
178_I	365_N	1.730	0.81
305_E	310_T	1.724	0.81
250_T	280_D	1.713	0.80
131_I	157_Q	1.698	0.79
46_L	49_K	1.688	0.79
74_H	78_Y	1.688	0.79
93_A	228_V	1.645	0.77
5_W	24_A	1.622	0.76
1_M	327_V	1.615	0.76
288_K	329_A	1.605	0.75
19_V	24_A	1.600	0.75
341_G	346_I	1.570	0.74
167_D	171_A	1.567	0.74
294_I	330_I	1.566	0.74
14_V	22_A	1.563	0.73
166_S	169_D	1.558	0.73
333_E	341_G	1.530	0.72
70_D	73_T	1.513	0.71
124_K	355_Q	1.507	0.71
269_T	334_E	1.495	0.70
231_A	275_Y	1.492	0.70
213_A	256_W	1.491	0.70
139_H	162_F	1.488	0.70
133_F	242_L	1.479	0.69
355_Q	369_S	1.474	0.69
134_A	138_M	1.464	0.68
15_S	18_D	1.461	0.68
213_A	260_T	1.458	0.68
303_M	318_N	1.454	0.68
255_Q	259_D	1.440	0.67
324_Y	383_V	1.434	0.67
22_A	370_A	1.425	0.66
130_Q	154_E	1.408	0.65
22_A	374_L	1.398	0.65
358_D	362_K	1.396	0.65
144_P	194_R	1.391	0.64
77_N	80_Q	1.390	0.64
82_I	86_Q	1.386	0.64
258_V	262_N	1.372	0.63
39_V	91_N	1.372	0.63
324_Y	387_I	1.371	0.63
365_N	369_S	1.358	0.62
42_V	94_Q	1.354	0.62
314_A	318_N	1.346	0.62
333_E	337_R	1.340	0.61
111_T	179_A	1.337	0.61
288_K	332_E	1.337	0.61
324_Y	389_R	1.330	0.61
36_N	185_E	1.322	0.60
50_A	54_D	1.316	0.60
205_K	247_I	1.312	0.60
79_E	214_V	1.309	0.59
139_H	155_I	1.300	0.59
277_V	301_S	1.298	0.59
321_V	326_V	1.297	0.59
189_T	192_Q	1.294	0.58
258_V	293_R	1.281	0.58
370_A	374_L	1.270	0.57
151_T	154_E	1.266	0.57
248_V	254_M	1.266	0.57
24_A	27_V	1.261	0.56
111_T	180_G	1.261	0.56
1_M	334_E	1.257	0.56
73_T	199_L	1.239	0.55
65_V	85_Y	1.237	0.55
26_G	347_P	1.234	0.55
152_E	156_A	1.224	0.54
333_E	336_R	1.213	0.53
74_H	214_V	1.209	0.53
331_V	384_E	1.207	0.53
45_I	92_L	1.199	0.53
101_C	231_A	1.185	0.52
132_E	135_A	1.179	0.51
257_M	262_N	1.170	0.51
287_I	330_I	1.168	0.51
303_M	314_A	1.165	0.50
114_D	117_Y	1.158	0.50
136_F	190_L	1.154	0.50
222_V	225_E	1.152	0.50
14_V	370_A	1.149	0.49
42_V	46_L	1.144	0.49
329_A	332_E	1.139	0.49
219_I	230_M	1.136	0.49
222_V	226_V	1.116	0.47
205_K	256_W	1.109	0.47
307_N	310_T	1.108	0.47
178_I	185_E	1.106	0.47
327_V	380_V	1.106	0.47
36_N	193_F	1.100	0.46
137_E	241_I	1.097	0.46
38_E	80_Q	1.096	0.46
76_G	79_E	1.092	0.46
101_C	334_E	1.091	0.46
213_A	217_K	1.090	0.46
301_S	321_V	1.080	0.45
258_V	264_M	1.079	0.45
283_L	304_R	1.078	0.45
269_T	295_Y	1.076	0.45
258_V	268_F	1.074	0.45
331_V	388_Q	1.074	0.45
36_N	178_I	1.071	0.45
127_R	305_E	1.056	0.44
178_I	187_G	1.052	0.43
10_P	48_R	1.052	0.43
69_E	200_Y	1.048	0.43
2_E	58_V	1.047	0.43
1_M	348_M	1.043	0.43
362_K	370_A	1.042	0.43
136_F	174_T	1.038	0.43
78_Y	214_V	1.037	0.43
70_D	81_W	1.032	0.42
123_S	375_K	1.026	0.42
14_V	33_H	1.022	0.42
322_D	325_E	1.021	0.42
362_K	369_S	1.017	0.41
211_N	214_V	1.015	0.41
301_S	314_A	1.014	0.41
205_K	252_E	1.012	0.41
36_N	365_N	1.010	0.41
74_H	79_E	1.010	0.41
4_T	347_P	1.010	0.41
85_Y	219_I	1.009	0.41
90_R	226_V	1.008	0.41
291_G	329_A	1.006	0.41
125_A	354_H	1.004	0.41
268_F	294_I	1.001	0.40
383_V	387_I	0.996	0.40
133_F	176_N	0.995	0.40
385_L	389_R	0.994	0.40
79_E	218_A	0.993	0.40
2_E	25_T	0.992	0.40
4_T	60_S	0.988	0.40
291_G	304_R	0.979	0.39
132_E	262_N	0.978	0.39
248_V	275_Y	0.977	0.39
219_I	228_V	0.969	0.38
86_Q	222_V	0.967	0.38
270_M	287_I	0.961	0.38
255_Q	290_F	0.961	0.38
224_E	265_A	0.958	0.38
356_M	375_K	0.957	0.38
128_F	133_F	0.956	0.38
277_V	321_V	0.954	0.38
270_M	286_M	0.952	0.37
142_K	194_R	0.942	0.37
49_K	52_I	0.941	0.37
45_I	91_N	0.940	0.37
157_Q	307_N	0.938	0.37
287_I	297_T	0.937	0.37
20_R	120_P	0.932	0.36
324_Y	328_K	0.932	0.36
75_T	199_L	0.929	0.36
336_R	340_E	0.924	0.36
41_S	88_T	0.922	0.36
47_K	51_I	0.922	0.36
100_V	336_R	0.918	0.35
137_E	242_L	0.918	0.35
219_I	309_K	0.914	0.35
69_E	108_L	0.914	0.35
190_L	194_R	0.908	0.35
263_S	293_R	0.908	0.35
205_K	240_P	0.907	0.35
348_M	369_S	0.905	0.35
65_V	92_L	0.904	0.35
162_F	165_M	0.904	0.35
160_E	164_T	0.898	0.34
301_S	315_A	0.897	0.34
75_T	78_Y	0.892	0.34
36_N	179_A	0.889	0.34
304_R	320_D	0.888	0.34
142_K	170_K	0.888	0.34
34_I	38_E	0.884	0.34
25_T	60_S	0.883	0.33
305_E	312_H	0.879	0.33
169_D	172_R	0.878	0.33
43_E	374_L	0.878	0.33
185_E	188_Y	0.878	0.33
362_K	371_I	0.878	0.33
327_V	386_A	0.877	0.33
254_M	258_V	0.874	0.33
259_D	262_N	0.868	0.33
123_S	324_Y	0.865	0.32
135_A	161_R	0.859	0.32
36_N	184_A	0.856	0.32
252_E	256_W	0.854	0.32
140_I	174_T	0.853	0.32
101_C	333_E	0.852	0.32
130_Q	309_K	0.851	0.32
285_D	291_G	0.850	0.32
181_L	184_A	0.846	0.31
133_F	260_T	0.844	0.31
90_R	222_V	0.842	0.31
166_S	170_K	0.842	0.31
126_L	354_H	0.840	0.31
3_Q	381_R	0.838	0.31
86_Q	90_R	0.836	0.31
283_L	291_G	0.836	0.31
315_A	356_M	0.832	0.31
268_F	275_Y	0.832	0.31
220_I	223_A	0.824	0.30
18_D	203_I	0.822	0.30
256_W	260_T	0.817	0.30
119_L	375_K	0.817	0.30
126_L	369_S	0.813	0.30
134_A	154_E	0.813	0.30
13_P	365_N	0.812	0.30
239_R	309_K	0.812	0.30
149_D	240_P	0.811	0.30
174_T	178_I	0.808	0.29
292_P	340_E	0.806	0.29
318_N	385_L	0.806	0.29
36_N	187_G	0.806	0.29
330_I	348_M	0.805	0.29
115_L	193_F	0.805	0.29
65_V	241_I	0.801	0.29
114_D	129_D	0.799	0.29
185_E	277_V	0.797	0.29
100_V	226_V	0.795	0.29
358_D	371_I	0.793	0.29
216_L	220_I	0.792	0.29
107_V	133_F	0.790	0.28
62_V	65_V	0.788	0.28
119_L	123_S	0.785	0.28
294_I	297_T	0.784	0.28
223_A	334_E	0.782	0.28
210_E	214_V	0.782	0.28
197_L	200_Y	0.782	0.28
129_D	262_N	0.780	0.28
153_E	157_Q	0.777	0.28
136_F	197_L	0.772	0.28
167_D	170_K	0.771	0.28
251_I	255_Q	0.770	0.27
197_L	202_D	0.768	0.27
132_E	154_E	0.768	0.27
231_A	295_Y	0.767	0.27
232_V	248_V	0.765	0.27
272_T	277_V	0.761	0.27
93_A	262_N	0.761	0.27
277_V	309_K	0.759	0.27
93_A	222_V	0.757	0.27
74_H	211_N	0.755	0.27
89_L	226_V	0.755	0.27
82_I	283_L	0.752	0.27
3_Q	22_A	0.750	0.26
184_A	188_Y	0.746	0.26
129_D	310_T	0.746	0.26
283_L	286_M	0.745	0.26
115_L	365_N	0.743	0.26
111_T	187_G	0.742	0.26
24_A	188_Y	0.741	0.26
129_D	132_E	0.739	0.26
27_V	60_S	0.736	0.26
43_E	225_E	0.734	0.26
65_V	111_T	0.734	0.26
129_D	135_A	0.732	0.26
375_K	379_E	0.728	0.25
209_R	252_E	0.724	0.25
384_E	388_Q	0.724	0.25
167_D	224_E	0.722	0.25
258_V	275_Y	0.718	0.25
269_T	375_K	0.718	0.25
183_G	221_P	0.718	0.25
33_H	51_I	0.717	0.25
85_Y	228_V	0.717	0.25
126_L	254_M	0.717	0.25
19_V	27_V	0.714	0.25
2_E	67_I	0.713	0.25
193_F	228_V	0.710	0.25
189_T	208_L	0.708	0.24
44_E	176_N	0.706	0.24
43_E	166_S	0.706	0.24
291_G	333_E	0.706	0.24
111_T	354_H	0.704	0.24
68_H	126_L	0.703	0.24
217_K	261_V	0.703	0.24
83_A	87_Q	0.702	0.24
174_T	190_L	0.702	0.24
209_R	242_L	0.701	0.24
119_L	354_H	0.699	0.24
324_Y	385_L	0.698	0.24
269_T	383_V	0.697	0.24
46_L	50_A	0.696	0.24
87_Q	94_Q	0.696	0.24
220_I	269_T	0.695	0.24
82_I	85_Y	0.694	0.24
90_R	137_E	0.693	0.24
327_V	348_M	0.693	0.24
272_T	302_T	0.687	0.24
66_P	108_L	0.683	0.23
123_S	369_S	0.682	0.23
42_V	87_Q	0.682	0.23
97_I	332_E	0.681	0.23
137_E	155_I	0.681	0.23
39_V	87_Q	0.679	0.23
338_K	341_G	0.675	0.23
338_K	345_L	0.673	0.23
24_A	49_K	0.672	0.23
336_R	341_G	0.666	0.23
68_H	219_I	0.664	0.23
29_T	48_R	0.663	0.22
116_E	124_K	0.663	0.22
247_I	257_M	0.659	0.22
108_L	208_L	0.658	0.22
138_M	159_A	0.658	0.22
101_C	188_Y	0.656	0.22
328_K	387_I	0.655	0.22
132_E	172_R	0.654	0.22
140_I	162_F	0.651	0.22
179_A	365_N	0.648	0.22
127_R	181_L	0.647	0.22
322_D	389_R	0.646	0.22
5_W	101_C	0.644	0.22
5_W	334_E	0.642	0.22
136_F	242_L	0.641	0.22
292_P	333_E	0.641	0.22
152_E	155_I	0.640	0.21
20_R	140_I	0.640	0.21
66_P	106_P	0.639	0.21
135_A	196_H	0.638	0.21
124_K	360_L	0.637	0.21
93_A	98_R	0.636	0.21
248_V	268_F	0.636	0.21
34_I	44_E	0.634	0.21
229_R	341_G	0.633	0.21
65_V	68_H	0.632	0.21
124_K	369_S	0.632	0.21
92_L	108_L	0.630	0.21
331_V	335_H	0.629	0.21
125_A	262_N	0.629	0.21
270_M	334_E	0.628	0.21
6_R	9_G	0.627	0.21
19_V	348_M	0.627	0.21
108_L	240_P	0.627	0.21
5_W	322_D	0.626	0.21
24_A	119_L	0.624	0.21
126_L	232_V	0.623	0.21
138_M	154_E	0.622	0.21
126_L	268_F	0.620	0.21
135_A	165_M	0.618	0.21
269_T	341_G	0.618	0.21
94_Q	139_H	0.616	0.20
135_A	162_F	0.616	0.20
213_A	261_V	0.616	0.20
262_N	293_R	0.615	0.20
101_C	134_A	0.615	0.20
259_D	291_G	0.614	0.20
11_N	191_D	0.614	0.20
19_V	119_L	0.611	0.20
193_F	365_N	0.611	0.20
46_L	95_C	0.611	0.20
100_V	321_V	0.610	0.20
65_V	179_A	0.609	0.20
4_T	56_G	0.609	0.20
108_L	136_F	0.607	0.20
41_S	147_E	0.607	0.20
223_A	265_A	0.606	0.20
314_A	321_V	0.604	0.20
50_A	88_T	0.600	0.20
182_P	381_R	0.599	0.20
100_V	288_K	0.599	0.20
219_I	241_I	0.596	0.20
101_C	224_E	0.593	0.20
16_L	55_A	0.589	0.19
125_A	364_T	0.589	0.19
205_K	213_A	0.588	0.19
132_E	165_M	0.587	0.19
185_E	193_F	0.587	0.19
315_A	375_K	0.587	0.19
362_K	365_N	0.587	0.19
191_D	194_R	0.587	0.19
97_I	206_A	0.587	0.19
125_A	369_S	0.585	0.19
187_G	365_N	0.585	0.19
25_T	354_H	0.583	0.19
127_R	185_E	0.583	0.19
186_E	190_L	0.581	0.19
19_V	85_Y	0.580	0.19
174_T	197_L	0.579	0.19
355_Q	360_L	0.577	0.19
202_D	206_A	0.576	0.19
69_E	136_F	0.575	0.19
48_R	182_P	0.574	0.19
13_P	363_K	0.574	0.19
206_A	256_W	0.574	0.19
1_M	346_I	0.573	0.19
44_E	346_I	0.573	0.19
53_E	58_V	0.572	0.19
277_V	304_R	0.572	0.19
321_V	374_L	0.572	0.19
87_Q	91_N	0.572	0.19
89_L	222_V	0.572	0.19
125_A	348_M	0.571	0.19
275_Y	380_V	0.571	0.19
144_P	289_Q	0.570	0.19
154_E	275_Y	0.570	0.19
74_H	207_K	0.570	0.19
159_A	361_K	0.569	0.19
180_G	276_G	0.569	0.19
119_L	248_V	0.569	0.19
19_V	52_I	0.568	0.19
52_I	257_M	0.567	0.19
334_E	383_V	0.566	0.19
61_V	347_P	0.566	0.19
178_I	232_V	0.566	0.19
140_I	170_K	0.565	0.18
205_K	253_D	0.564	0.18
301_S	318_N	0.564	0.18
104_F	350_P	0.562	0.18
83_A	211_N	0.562	0.18
323_M	374_L	0.560	0.18
15_S	370_A	0.554	0.18
287_I	329_A	0.553	0.18
261_V	293_R	0.553	0.18
127_R	186_E	0.552	0.18
50_A	297_T	0.551	0.18
49_K	95_C	0.551	0.18
179_A	184_A	0.551	0.18
302_T	315_A	0.551	0.18
79_E	83_A	0.550	0.18
219_I	297_T	0.550	0.18
262_N	265_A	0.550	0.18
259_D	332_E	0.549	0.18
88_T	209_R	0.549	0.18
276_G	320_D	0.548	0.18
85_Y	230_M	0.548	0.18
74_H	126_L	0.547	0.18
117_Y	123_S	0.547	0.18
231_A	334_E	0.546	0.18
130_Q	310_T	0.545	0.18
231_A	333_E	0.543	0.18
255_Q	285_D	0.542	0.18
220_I	293_R	0.541	0.18
286_M	291_G	0.540	0.18
147_E	155_I	0.540	0.18
279_A	304_R	0.540	0.18
276_G	380_V	0.540	0.18
164_T	169_D	0.539	0.18
275_Y	284_V	0.537	0.17
117_Y	127_R	0.537	0.17
82_I	218_A	0.537	0.17
108_L	186_E	0.535	0.17
165_M	169_D	0.535	0.17
122_G	359_D	0.534	0.17
348_M	384_E	0.534	0.17
77_N	85_Y	0.534	0.17
131_I	307_N	0.534	0.17
175_R	178_I	0.533	0.17
264_M	282_D	0.532	0.17
198_E	348_M	0.532	0.17
43_E	203_I	0.530	0.17
14_V	329_A	0.530	0.17
90_R	336_R	0.529	0.17
160_E	168_E	0.529	0.17
146_A	151_T	0.529	0.17
310_T	356_M	0.528	0.17
76_G	218_A	0.527	0.17
11_N	51_I	0.527	0.17
43_E	145_G	0.526	0.17
39_V	201_K	0.526	0.17
282_D	332_E	0.525	0.17
207_K	211_N	0.524	0.17
16_L	29_T	0.524	0.17
252_E	285_D	0.523	0.17
98_R	229_R	0.522	0.17
65_V	91_N	0.522	0.17
302_T	310_T	0.521	0.17
50_A	282_D	0.521	0.17
200_Y	203_I	0.520	0.17
165_M	348_M	0.520	0.17
1_M	4_T	0.520	0.17
16_L	248_V	0.519	0.17
177_I	187_G	0.519	0.17
196_H	231_A	0.518	0.17
111_T	115_L	0.518	0.17
5_W	19_V	0.517	0.17
268_F	346_I	0.517	0.17
87_Q	90_R	0.516	0.17
2_E	26_G	0.516	0.17
174_T	310_T	0.515	0.17
51_I	54_D	0.514	0.17
14_V	123_S	0.513	0.17
16_L	20_R	0.513	0.17
251_I	275_Y	0.513	0.17
356_M	360_L	0.513	0.17
98_R	169_D	0.512	0.17
8_Y	374_L	0.511	0.17
196_H	254_M	0.511	0.17
28_V	296_F	0.511	0.17
181_L	188_Y	0.511	0.17
187_G	301_S	0.511	0.17
318_N	383_V	0.510	0.16
78_Y	82_I	0.510	0.16
8_Y	173_L	0.509	0.16
18_D	370_A	0.508	0.16
156_A	160_E	0.506	0.16
41_S	87_Q	0.506	0.16
27_V	50_A	0.506	0.16
165_M	209_R	0.505	0.16
153_E	168_E	0.505	0.16
27_V	55_A	0.505	0.16
334_E	384_E	0.504	0.16
8_Y	187_G	0.504	0.16
88_T	166_S	0.504	0.16
283_L	312_H	0.504	0.16
89_L	145_G	0.503	0.16
129_D	275_Y	0.503	0.16
17_A	55_A	0.503	0.16
328_K	332_E	0.502	0.16
192_Q	195_K	0.501	0.16
180_G	184_A	0.501	0.16
193_F	355_Q	0.500	0.16
1_M	383_V	0.500	0.16
7_W	12_D	0.500	0.16
6_R	12_D	0.500	0.16

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4eacA	1	1	100	0.517	Contact Map
3bdkA	2	0.8452	100	0.668	Contact Map
1tz9A	2	0.8604	100	0.759	Contact Map
3vniA	4	0.6878	99.6	0.923	Contact Map
3lmzA	2	0.6015	99.5	0.926	Contact Map
2hk0A	3	0.6929	99.5	0.926	Contact Map
3obeA	1	0.6548	99.5	0.928	Contact Map
3cqjA	2	0.665	99.4	0.928	Contact Map
3u0hA	3	0.6802	99.4	0.928	Contact Map
1i60A	1	0.6751	99.4	0.929	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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