GREMLIN Database
UXUA - Mannonate dehydratase
UniProt: P24215 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11066
Length: 394 (385)
Sequences: 570 (366)
Seq/√Len: 18.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_H44_E3.9451.00
65_V88_T3.8561.00
220_I230_M3.8071.00
224_E263_S3.7381.00
212_F232_V3.6241.00
42_V95_C3.6011.00
272_T326_V3.5871.00
90_R225_E3.5241.00
297_T330_I3.4561.00
204_D207_K3.3351.00
89_L100_V3.3061.00
44_E47_K3.0820.99
251_I289_Q3.0170.99
93_A226_V2.9490.99
254_M275_Y2.8100.98
255_Q289_Q2.7840.98
251_I285_D2.7690.98
194_R198_E2.6590.98
89_L228_V2.6320.98
132_E161_R2.6190.97
383_V386_A2.6120.97
159_A163_A2.5630.97
4_T26_G2.4400.96
2_E60_S2.4380.96
86_Q218_A2.3830.96
49_K53_E2.2570.94
220_I263_S2.2530.94
251_I290_F2.2490.94
65_V89_L2.2230.94
68_H81_W2.2210.93
315_A318_N2.1960.93
284_V325_E2.1860.93
285_D289_Q2.1620.93
231_A269_T2.1610.93
324_Y386_A2.1560.92
138_M155_I2.1390.92
34_I41_S2.1320.92
209_R256_W2.1210.92
101_C269_T2.0950.91
287_I291_G2.0930.91
83_A86_Q2.0590.91
198_E201_K2.0430.90
357_L370_A2.0310.90
287_I294_I2.0060.89
62_V92_L2.0000.89
327_V383_V1.9730.89
3_Q384_E1.9540.88
275_Y286_M1.9390.88
250_T278_R1.9000.87
33_H47_K1.9000.87
277_V302_T1.8980.86
139_H159_A1.8960.86
303_M320_D1.8810.86
123_S356_M1.8740.86
254_M268_F1.8630.85
282_D285_D1.8630.85
371_I374_L1.8490.85
161_R165_M1.8300.84
29_T52_I1.8300.84
100_V228_V1.8240.84
331_V387_I1.8220.84
285_D290_F1.8080.84
118_V124_K1.8060.84
121_D375_K1.7670.82
178_I365_N1.7300.81
305_E310_T1.7240.81
250_T280_D1.7130.80
131_I157_Q1.6980.79
46_L49_K1.6880.79
74_H78_Y1.6880.79
93_A228_V1.6450.77
5_W24_A1.6220.76
1_M327_V1.6150.76
288_K329_A1.6050.75
19_V24_A1.6000.75
341_G346_I1.5700.74
167_D171_A1.5670.74
294_I330_I1.5660.74
14_V22_A1.5630.73
166_S169_D1.5580.73
333_E341_G1.5300.72
70_D73_T1.5130.71
124_K355_Q1.5070.71
269_T334_E1.4950.70
231_A275_Y1.4920.70
213_A256_W1.4910.70
139_H162_F1.4880.70
133_F242_L1.4790.69
355_Q369_S1.4740.69
134_A138_M1.4640.68
15_S18_D1.4610.68
213_A260_T1.4580.68
303_M318_N1.4540.68
255_Q259_D1.4400.67
324_Y383_V1.4340.67
22_A370_A1.4250.66
130_Q154_E1.4080.65
22_A374_L1.3980.65
358_D362_K1.3960.65
144_P194_R1.3910.64
77_N80_Q1.3900.64
82_I86_Q1.3860.64
258_V262_N1.3720.63
39_V91_N1.3720.63
324_Y387_I1.3710.63
365_N369_S1.3580.62
42_V94_Q1.3540.62
314_A318_N1.3460.62
333_E337_R1.3400.61
111_T179_A1.3370.61
288_K332_E1.3370.61
324_Y389_R1.3300.61
36_N185_E1.3220.60
50_A54_D1.3160.60
205_K247_I1.3120.60
79_E214_V1.3090.59
139_H155_I1.3000.59
277_V301_S1.2980.59
321_V326_V1.2970.59
189_T192_Q1.2940.58
258_V293_R1.2810.58
370_A374_L1.2700.57
151_T154_E1.2660.57
248_V254_M1.2660.57
24_A27_V1.2610.56
111_T180_G1.2610.56
1_M334_E1.2570.56
73_T199_L1.2390.55
65_V85_Y1.2370.55
26_G347_P1.2340.55
152_E156_A1.2240.54
333_E336_R1.2130.53
74_H214_V1.2090.53
331_V384_E1.2070.53
45_I92_L1.1990.53
101_C231_A1.1850.52
132_E135_A1.1790.51
257_M262_N1.1700.51
287_I330_I1.1680.51
303_M314_A1.1650.50
114_D117_Y1.1580.50
136_F190_L1.1540.50
222_V225_E1.1520.50
14_V370_A1.1490.49
42_V46_L1.1440.49
329_A332_E1.1390.49
219_I230_M1.1360.49
222_V226_V1.1160.47
205_K256_W1.1090.47
307_N310_T1.1080.47
178_I185_E1.1060.47
327_V380_V1.1060.47
36_N193_F1.1000.46
137_E241_I1.0970.46
38_E80_Q1.0960.46
76_G79_E1.0920.46
101_C334_E1.0910.46
213_A217_K1.0900.46
301_S321_V1.0800.45
258_V264_M1.0790.45
283_L304_R1.0780.45
269_T295_Y1.0760.45
258_V268_F1.0740.45
331_V388_Q1.0740.45
36_N178_I1.0710.45
127_R305_E1.0560.44
178_I187_G1.0520.43
10_P48_R1.0520.43
69_E200_Y1.0480.43
2_E58_V1.0470.43
1_M348_M1.0430.43
362_K370_A1.0420.43
136_F174_T1.0380.43
78_Y214_V1.0370.43
70_D81_W1.0320.42
123_S375_K1.0260.42
14_V33_H1.0220.42
322_D325_E1.0210.42
362_K369_S1.0170.41
211_N214_V1.0150.41
301_S314_A1.0140.41
205_K252_E1.0120.41
36_N365_N1.0100.41
74_H79_E1.0100.41
4_T347_P1.0100.41
85_Y219_I1.0090.41
90_R226_V1.0080.41
291_G329_A1.0060.41
125_A354_H1.0040.41
268_F294_I1.0010.40
383_V387_I0.9960.40
133_F176_N0.9950.40
385_L389_R0.9940.40
79_E218_A0.9930.40
2_E25_T0.9920.40
4_T60_S0.9880.40
291_G304_R0.9790.39
132_E262_N0.9780.39
248_V275_Y0.9770.39
219_I228_V0.9690.38
86_Q222_V0.9670.38
270_M287_I0.9610.38
255_Q290_F0.9610.38
224_E265_A0.9580.38
356_M375_K0.9570.38
128_F133_F0.9560.38
277_V321_V0.9540.38
270_M286_M0.9520.37
142_K194_R0.9420.37
49_K52_I0.9410.37
45_I91_N0.9400.37
157_Q307_N0.9380.37
287_I297_T0.9370.37
20_R120_P0.9320.36
324_Y328_K0.9320.36
75_T199_L0.9290.36
336_R340_E0.9240.36
41_S88_T0.9220.36
47_K51_I0.9220.36
100_V336_R0.9180.35
137_E242_L0.9180.35
219_I309_K0.9140.35
69_E108_L0.9140.35
190_L194_R0.9080.35
263_S293_R0.9080.35
205_K240_P0.9070.35
348_M369_S0.9050.35
65_V92_L0.9040.35
162_F165_M0.9040.35
160_E164_T0.8980.34
301_S315_A0.8970.34
75_T78_Y0.8920.34
36_N179_A0.8890.34
304_R320_D0.8880.34
142_K170_K0.8880.34
34_I38_E0.8840.34
25_T60_S0.8830.33
305_E312_H0.8790.33
169_D172_R0.8780.33
43_E374_L0.8780.33
185_E188_Y0.8780.33
362_K371_I0.8780.33
327_V386_A0.8770.33
254_M258_V0.8740.33
259_D262_N0.8680.33
123_S324_Y0.8650.32
135_A161_R0.8590.32
36_N184_A0.8560.32
252_E256_W0.8540.32
140_I174_T0.8530.32
101_C333_E0.8520.32
130_Q309_K0.8510.32
285_D291_G0.8500.32
181_L184_A0.8460.31
133_F260_T0.8440.31
90_R222_V0.8420.31
166_S170_K0.8420.31
126_L354_H0.8400.31
3_Q381_R0.8380.31
86_Q90_R0.8360.31
283_L291_G0.8360.31
315_A356_M0.8320.31
268_F275_Y0.8320.31
220_I223_A0.8240.30
18_D203_I0.8220.30
256_W260_T0.8170.30
119_L375_K0.8170.30
126_L369_S0.8130.30
134_A154_E0.8130.30
13_P365_N0.8120.30
239_R309_K0.8120.30
149_D240_P0.8110.30
174_T178_I0.8080.29
292_P340_E0.8060.29
318_N385_L0.8060.29
36_N187_G0.8060.29
330_I348_M0.8050.29
115_L193_F0.8050.29
65_V241_I0.8010.29
114_D129_D0.7990.29
185_E277_V0.7970.29
100_V226_V0.7950.29
358_D371_I0.7930.29
216_L220_I0.7920.29
107_V133_F0.7900.28
62_V65_V0.7880.28
119_L123_S0.7850.28
294_I297_T0.7840.28
223_A334_E0.7820.28
210_E214_V0.7820.28
197_L200_Y0.7820.28
129_D262_N0.7800.28
153_E157_Q0.7770.28
136_F197_L0.7720.28
167_D170_K0.7710.28
251_I255_Q0.7700.27
197_L202_D0.7680.27
132_E154_E0.7680.27
231_A295_Y0.7670.27
232_V248_V0.7650.27
272_T277_V0.7610.27
93_A262_N0.7610.27
277_V309_K0.7590.27
93_A222_V0.7570.27
74_H211_N0.7550.27
89_L226_V0.7550.27
82_I283_L0.7520.27
3_Q22_A0.7500.26
184_A188_Y0.7460.26
129_D310_T0.7460.26
283_L286_M0.7450.26
115_L365_N0.7430.26
111_T187_G0.7420.26
24_A188_Y0.7410.26
129_D132_E0.7390.26
27_V60_S0.7360.26
43_E225_E0.7340.26
65_V111_T0.7340.26
129_D135_A0.7320.26
375_K379_E0.7280.25
209_R252_E0.7240.25
384_E388_Q0.7240.25
167_D224_E0.7220.25
258_V275_Y0.7180.25
269_T375_K0.7180.25
183_G221_P0.7180.25
33_H51_I0.7170.25
85_Y228_V0.7170.25
126_L254_M0.7170.25
19_V27_V0.7140.25
2_E67_I0.7130.25
193_F228_V0.7100.25
189_T208_L0.7080.24
44_E176_N0.7060.24
43_E166_S0.7060.24
291_G333_E0.7060.24
111_T354_H0.7040.24
68_H126_L0.7030.24
217_K261_V0.7030.24
83_A87_Q0.7020.24
174_T190_L0.7020.24
209_R242_L0.7010.24
119_L354_H0.6990.24
324_Y385_L0.6980.24
269_T383_V0.6970.24
46_L50_A0.6960.24
87_Q94_Q0.6960.24
220_I269_T0.6950.24
82_I85_Y0.6940.24
90_R137_E0.6930.24
327_V348_M0.6930.24
272_T302_T0.6870.24
66_P108_L0.6830.23
123_S369_S0.6820.23
42_V87_Q0.6820.23
97_I332_E0.6810.23
137_E155_I0.6810.23
39_V87_Q0.6790.23
338_K341_G0.6750.23
338_K345_L0.6730.23
24_A49_K0.6720.23
336_R341_G0.6660.23
68_H219_I0.6640.23
29_T48_R0.6630.22
116_E124_K0.6630.22
247_I257_M0.6590.22
108_L208_L0.6580.22
138_M159_A0.6580.22
101_C188_Y0.6560.22
328_K387_I0.6550.22
132_E172_R0.6540.22
140_I162_F0.6510.22
179_A365_N0.6480.22
127_R181_L0.6470.22
322_D389_R0.6460.22
5_W101_C0.6440.22
5_W334_E0.6420.22
136_F242_L0.6410.22
292_P333_E0.6410.22
152_E155_I0.6400.21
20_R140_I0.6400.21
66_P106_P0.6390.21
135_A196_H0.6380.21
124_K360_L0.6370.21
93_A98_R0.6360.21
248_V268_F0.6360.21
34_I44_E0.6340.21
229_R341_G0.6330.21
65_V68_H0.6320.21
124_K369_S0.6320.21
92_L108_L0.6300.21
331_V335_H0.6290.21
125_A262_N0.6290.21
270_M334_E0.6280.21
6_R9_G0.6270.21
19_V348_M0.6270.21
108_L240_P0.6270.21
5_W322_D0.6260.21
24_A119_L0.6240.21
126_L232_V0.6230.21
138_M154_E0.6220.21
126_L268_F0.6200.21
135_A165_M0.6180.21
269_T341_G0.6180.21
94_Q139_H0.6160.20
135_A162_F0.6160.20
213_A261_V0.6160.20
262_N293_R0.6150.20
101_C134_A0.6150.20
259_D291_G0.6140.20
11_N191_D0.6140.20
19_V119_L0.6110.20
193_F365_N0.6110.20
46_L95_C0.6110.20
100_V321_V0.6100.20
65_V179_A0.6090.20
4_T56_G0.6090.20
108_L136_F0.6070.20
41_S147_E0.6070.20
223_A265_A0.6060.20
314_A321_V0.6040.20
50_A88_T0.6000.20
182_P381_R0.5990.20
100_V288_K0.5990.20
219_I241_I0.5960.20
101_C224_E0.5930.20
16_L55_A0.5890.19
125_A364_T0.5890.19
205_K213_A0.5880.19
132_E165_M0.5870.19
185_E193_F0.5870.19
315_A375_K0.5870.19
362_K365_N0.5870.19
191_D194_R0.5870.19
97_I206_A0.5870.19
125_A369_S0.5850.19
187_G365_N0.5850.19
25_T354_H0.5830.19
127_R185_E0.5830.19
186_E190_L0.5810.19
19_V85_Y0.5800.19
174_T197_L0.5790.19
355_Q360_L0.5770.19
202_D206_A0.5760.19
69_E136_F0.5750.19
48_R182_P0.5740.19
13_P363_K0.5740.19
206_A256_W0.5740.19
1_M346_I0.5730.19
44_E346_I0.5730.19
53_E58_V0.5720.19
277_V304_R0.5720.19
321_V374_L0.5720.19
87_Q91_N0.5720.19
89_L222_V0.5720.19
125_A348_M0.5710.19
275_Y380_V0.5710.19
144_P289_Q0.5700.19
154_E275_Y0.5700.19
74_H207_K0.5700.19
159_A361_K0.5690.19
180_G276_G0.5690.19
119_L248_V0.5690.19
19_V52_I0.5680.19
52_I257_M0.5670.19
334_E383_V0.5660.19
61_V347_P0.5660.19
178_I232_V0.5660.19
140_I170_K0.5650.18
205_K253_D0.5640.18
301_S318_N0.5640.18
104_F350_P0.5620.18
83_A211_N0.5620.18
323_M374_L0.5600.18
15_S370_A0.5540.18
287_I329_A0.5530.18
261_V293_R0.5530.18
127_R186_E0.5520.18
50_A297_T0.5510.18
49_K95_C0.5510.18
179_A184_A0.5510.18
302_T315_A0.5510.18
79_E83_A0.5500.18
219_I297_T0.5500.18
262_N265_A0.5500.18
259_D332_E0.5490.18
88_T209_R0.5490.18
276_G320_D0.5480.18
85_Y230_M0.5480.18
74_H126_L0.5470.18
117_Y123_S0.5470.18
231_A334_E0.5460.18
130_Q310_T0.5450.18
231_A333_E0.5430.18
255_Q285_D0.5420.18
220_I293_R0.5410.18
286_M291_G0.5400.18
147_E155_I0.5400.18
279_A304_R0.5400.18
276_G380_V0.5400.18
164_T169_D0.5390.18
275_Y284_V0.5370.17
117_Y127_R0.5370.17
82_I218_A0.5370.17
108_L186_E0.5350.17
165_M169_D0.5350.17
122_G359_D0.5340.17
348_M384_E0.5340.17
77_N85_Y0.5340.17
131_I307_N0.5340.17
175_R178_I0.5330.17
264_M282_D0.5320.17
198_E348_M0.5320.17
43_E203_I0.5300.17
14_V329_A0.5300.17
90_R336_R0.5290.17
160_E168_E0.5290.17
146_A151_T0.5290.17
310_T356_M0.5280.17
76_G218_A0.5270.17
11_N51_I0.5270.17
43_E145_G0.5260.17
39_V201_K0.5260.17
282_D332_E0.5250.17
207_K211_N0.5240.17
16_L29_T0.5240.17
252_E285_D0.5230.17
98_R229_R0.5220.17
65_V91_N0.5220.17
302_T310_T0.5210.17
50_A282_D0.5210.17
200_Y203_I0.5200.17
165_M348_M0.5200.17
1_M4_T0.5200.17
16_L248_V0.5190.17
177_I187_G0.5190.17
196_H231_A0.5180.17
111_T115_L0.5180.17
5_W19_V0.5170.17
268_F346_I0.5170.17
87_Q90_R0.5160.17
2_E26_G0.5160.17
174_T310_T0.5150.17
51_I54_D0.5140.17
14_V123_S0.5130.17
16_L20_R0.5130.17
251_I275_Y0.5130.17
356_M360_L0.5130.17
98_R169_D0.5120.17
8_Y374_L0.5110.17
196_H254_M0.5110.17
28_V296_F0.5110.17
181_L188_Y0.5110.17
187_G301_S0.5110.17
318_N383_V0.5100.16
78_Y82_I0.5100.16
8_Y173_L0.5090.16
18_D370_A0.5080.16
156_A160_E0.5060.16
41_S87_Q0.5060.16
27_V50_A0.5060.16
165_M209_R0.5050.16
153_E168_E0.5050.16
27_V55_A0.5050.16
334_E384_E0.5040.16
8_Y187_G0.5040.16
88_T166_S0.5040.16
283_L312_H0.5040.16
89_L145_G0.5030.16
129_D275_Y0.5030.16
17_A55_A0.5030.16
328_K332_E0.5020.16
192_Q195_K0.5010.16
180_G184_A0.5010.16
193_F355_Q0.5000.16
1_M383_V0.5000.16
7_W12_D0.5000.16
6_R12_D0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4eacA 1 1 100 0.517 Contact Map
3bdkA 2 0.8452 100 0.668 Contact Map
1tz9A 2 0.8604 100 0.759 Contact Map
3vniA 4 0.6878 99.6 0.923 Contact Map
3lmzA 2 0.6015 99.5 0.926 Contact Map
2hk0A 3 0.6929 99.5 0.926 Contact Map
3obeA 1 0.6548 99.5 0.928 Contact Map
3cqjA 2 0.665 99.4 0.928 Contact Map
3u0hA 3 0.6802 99.4 0.928 Contact Map
1i60A 1 0.6751 99.4 0.929 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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