GREMLIN Database
PHEP - Phenylalanine-specific permease
UniProt: P24207 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10708
Length: 458 (422)
Sequences: 24768 (15913)
Seq/√Len: 774.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
147_N349_G4.4791.00
331_F343_N4.3701.00
391_R395_A3.5221.00
383_I418_I3.2811.00
64_G254_L3.2701.00
334_R343_N3.1561.00
240_K244_K3.0401.00
88_A325_Q2.8261.00
24_H236_R2.8251.00
235_A241_S2.7631.00
104_G322_L2.7291.00
237_D240_K2.6801.00
29_Q248_Q2.6291.00
323_S333_T2.5881.00
336_S342_I2.5571.00
140_A353_S2.5431.00
179_G263_V2.4931.00
331_F334_R2.4681.00
233_A324_V2.4551.00
25_N248_Q2.3751.00
439_I443_V2.3571.00
76_E393_R2.3051.00
92_Y100_G2.2931.00
386_C417_C2.2801.00
177_G181_W2.2551.00
234_E317_R2.2531.00
148_A152_V2.1991.00
282_M285_H2.1911.00
320_F324_V2.1791.00
443_V446_V2.1751.00
346_M350_A2.1681.00
25_N241_S2.1101.00
95_W391_R2.0911.00
144_I353_S2.0881.00
155_R159_E2.0841.00
25_N29_Q2.0841.00
147_N345_L2.0811.00
28_I235_A2.0791.00
291_V295_A2.0721.00
415_Y419_A2.0411.00
244_K248_Q2.0211.00
166_L170_L2.0031.00
151_L342_I2.0011.00
29_Q252_R1.9801.00
139_A356_V1.9511.00
326_G330_K1.9311.00
140_A356_V1.9311.00
73_Q386_C1.9291.00
108_W348_S1.9221.00
24_H27_H1.9101.00
92_Y97_P1.9091.00
19_L335_V1.9071.00
336_S340_V1.8811.00
48_A56_V1.8791.00
332_L347_L1.8661.00
65_I69_L1.8541.00
95_W387_L1.8411.00
269_P272_E1.8081.00
272_E286_N1.8061.00
282_M286_N1.7821.00
247_N251_Y1.7811.00
446_V450_M1.7761.00
419_A423_M1.7661.00
237_D241_S1.7541.00
387_L418_I1.7421.00
412_F416_L1.7371.00
150_N309_N1.7321.00
27_H162_F1.7091.00
91_A103_S1.7081.00
23_L27_H1.6781.00
59_G214_S1.6701.00
32_A249_V1.6611.00
103_S384_M1.6571.00
151_L346_M1.6521.00
144_I349_G1.6491.00
66_I420_F1.6451.00
391_R394_A1.6431.00
338_R342_I1.6411.00
251_Y255_L1.6151.00
119_L308_Y1.6131.00
96_G99_A1.5981.00
143_F352_T1.5981.00
170_L174_G1.5831.00
126_M138_W1.5651.00
276_N282_M1.5541.00
63_A218_I1.5391.00
134_P137_I1.5381.00
115_G352_T1.5161.00
193_S196_N1.4981.00
171_A299_V1.4961.00
237_D244_K1.4951.00
319_L344_S1.4941.00
231_T313_Y1.4821.00
119_L143_F1.4761.00
448_L451_A1.4621.00
343_N347_L1.4591.00
315_N348_S1.4581.00
276_N279_P1.4581.00
84_S233_A1.4491.00
443_V447_F1.4491.00
122_A301_L1.4451.00
169_V173_I1.4441.00
436_L439_I1.4441.00
193_S197_L1.4431.00
320_F335_V1.4411.00
387_L391_R1.4411.00
143_F349_G1.4361.00
152_V338_R1.4351.00
447_F451_A1.4301.00
65_I416_L1.4261.00
140_A144_I1.4221.00
180_L263_V1.4121.00
445_I449_F1.4081.00
69_L416_L1.4011.00
147_N346_M1.3961.00
330_K333_T1.3951.00
433_D447_F1.3931.00
330_K334_R1.3921.00
316_S345_L1.3871.00
91_A384_M1.3751.00
19_L320_F1.3721.00
285_H293_A1.3691.00
285_H290_N1.3651.00
71_M250_V1.3571.00
20_H339_G1.3551.00
133_V137_I1.3421.00
442_P446_V1.3351.00
27_H158_G1.3341.00
436_L443_V1.3331.00
238_P243_P1.3251.00
23_L28_I1.3201.00
334_R342_I1.3191.00
294_S298_F1.3121.00
55_A204_F1.3081.00
71_M246_V1.2981.00
81_E93_K1.2911.00
70_I386_C1.2911.00
95_W99_A1.2871.00
43_L121_A1.2811.00
122_A142_F1.2781.00
25_N244_K1.2761.00
23_L158_G1.2731.00
183_L266_A1.2671.00
441_L445_I1.2661.00
435_R438_A1.2651.00
319_L328_A1.2591.00
83_V89_H1.2591.00
72_R247_N1.2591.00
36_A253_I1.2571.00
255_L259_G1.2561.00
94_Y388_A1.2531.00
241_S244_K1.2521.00
176_I259_G1.2371.00
390_L415_Y1.2361.00
432_D435_R1.2261.00
26_R30_L1.2241.00
437_S441_L1.2171.00
409_L413_G1.2161.00
149_V160_T1.2111.00
444_W448_L1.2081.00
89_H93_K1.2061.00
31_I231_T1.1991.00
433_D436_L1.1951.00
83_V93_K1.1911.00
57_L262_V1.1891.00
73_Q414_N1.1871.00
118_E307_V1.1851.00
108_W319_L1.1831.00
423_M427_L1.1821.00
136_W140_A1.1761.00
146_I308_Y1.1681.00
175_M179_G1.1551.00
32_A228_I1.1521.00
422_G426_L1.1491.00
28_I245_A1.1471.00
49_I56_V1.1381.00
434_M438_A1.1321.00
74_L87_F1.1311.00
181_W186_G1.1181.00
400_G403_T1.1121.00
394_A411_P1.1101.00
101_F105_W1.1101.00
193_S198_W1.1091.00
236_R241_S1.1091.00
412_F415_Y1.1051.00
383_I422_G1.1041.00
33_L252_R1.1031.00
439_I446_V1.1011.00
335_V339_G1.0991.00
161_E309_N1.0971.00
55_A211_L1.0971.00
278_S282_M1.0951.00
174_G178_F1.0911.00
350_A354_L1.0891.00
410_Y414_N1.0891.00
324_V333_T1.0841.00
173_I177_G1.0831.00
434_M437_S1.0821.00
78_V90_F1.0801.00
270_W273_V1.0771.00
192_A195_D1.0751.00
180_L184_F1.0731.00
179_G267_L1.0701.00
160_T164_F1.0691.00
389_H414_N1.0681.00
141_A145_I1.0661.00
137_I141_A1.0651.00
88_A321_G1.0651.00
411_P415_Y1.0641.00
61_G258_I1.0591.00
22_G236_R1.0511.00
343_N346_M1.0491.00
159_E163_W1.0451.00
76_E79_V1.0431.00
91_A99_A1.0321.00
79_V404_Q1.0281.00
154_V313_Y1.0271.00
409_L412_F1.0271.00
144_I148_A1.0131.00
123_G138_W1.0091.00
212_I423_M1.0071.00
33_L253_I1.0061.00
147_N151_L1.0041.00
151_L340_V1.0041.00
126_M130_F1.0031.00
232_A242_I0.9981.00
80_E403_T0.9921.00
417_C421_L0.9891.00
439_I450_M0.9841.00
223_G378_L0.9831.00
383_I421_L0.9821.00
418_I422_G0.9731.00
169_V256_F0.9731.00
269_P286_N0.9671.00
164_F306_S0.9631.00
433_D437_S0.9631.00
126_M301_L0.9591.00
196_N199_R0.9571.00
151_L336_S0.9551.00
194_I197_L0.9541.00
439_I442_P0.9491.00
386_C418_I0.9471.00
30_L162_F0.9451.00
176_I263_V0.9441.00
181_W184_F0.9401.00
226_E230_I0.9351.00
57_L265_L0.9251.00
443_V448_L0.9251.00
107_Y111_F0.9181.00
19_L317_R0.9171.00
288_D292_V0.9161.00
26_R162_F0.9121.00
248_Q252_R0.9111.00
85_G89_H0.9101.00
117_A371_M0.9101.00
176_I180_L0.9091.00
254_L258_I0.9081.00
208_W211_L0.9071.00
168_K303_A0.9051.00
117_A220_F0.9051.00
183_L186_G0.9051.00
80_E401_R0.9041.00
279_P284_F0.9031.00
138_W141_A0.8971.00
433_D439_I0.8961.00
332_L343_N0.8951.00
92_Y325_Q0.8941.00
64_G222_F0.8901.00
289_S292_V0.8871.00
146_I309_N0.8861.00
440_L443_V0.8851.00
437_S443_V0.8851.00
435_R439_I0.8831.00
445_I448_L0.8831.00
423_M426_L0.8811.00
402_E406_K0.8761.00
342_I346_M0.8761.00
22_G155_R0.8671.00
399_Q403_T0.8661.00
145_I305_L0.8641.00
69_L413_G0.8641.00
436_L447_F0.8631.00
85_G88_A0.8631.00
328_A332_L0.8591.00
426_L430_T0.8581.00
122_A305_L0.8581.00
383_I387_L0.8551.00
175_M284_F0.8521.00
19_L234_E0.8511.00
195_D198_W0.8481.00
336_S339_G0.8461.00
27_H159_E0.8461.00
204_F207_G0.8431.00
61_G65_I0.8421.00
105_W328_A0.8391.00
436_L449_F0.8391.00
312_V349_G0.8381.00
443_V450_M0.8381.00
181_W185_S0.8321.00
133_V136_W0.8311.00
122_A304_S0.8261.00
148_A151_L0.8251.00
37_I40_G0.8241.00
201_G205_A0.8231.00
262_V266_A0.8191.00
434_M447_F0.8171.00
70_I421_L0.8141.00
204_F211_L0.8131.00
68_F247_N0.8101.00
68_F72_R0.8101.00
127_Q131_P0.8101.00
136_W356_V0.8081.00
58_L211_L0.8061.00
279_P283_I0.8041.00
267_L283_I0.8031.00
446_V449_F0.8011.00
91_A388_A0.7981.00
203_F206_T0.7951.00
120_T370_L0.7931.00
223_G382_W0.7891.00
98_F102_L0.7891.00
69_L73_Q0.7891.00
438_A442_P0.7881.00
55_A203_F0.7851.00
438_A441_L0.7831.00
143_F356_V0.7801.00
213_L217_V0.7761.00
349_G353_S0.7761.00
401_R404_Q0.7731.00
51_M54_P0.7721.00
373_L377_T0.7721.00
433_D446_V0.7701.00
421_L424_I0.7661.00
290_N294_S0.7661.00
159_E162_F0.7651.00
37_I168_K0.7641.00
99_A384_M0.7641.00
80_E404_Q0.7641.00
275_S279_P0.7621.00
207_G210_G0.7601.00
22_G154_V0.7601.00
77_M389_H0.7551.00
243_P246_V0.7541.00
227_L314_S0.7531.00
414_N418_I0.7461.00
123_G126_M0.7441.00
390_L394_A0.7431.00
433_D443_V0.7421.00
341_P344_S0.7401.00
25_N245_A0.7401.00
146_I312_V0.7361.00
439_I444_W0.7361.00
151_L338_R0.7331.00
434_M439_I0.7321.00
152_V156_L0.7271.00
390_L414_N0.7211.00
197_L201_G0.7181.00
127_Q135_T0.7171.00
180_L259_G0.7161.00
194_I198_W0.7151.00
202_G205_A0.7131.00
112_V351_I0.7121.00
36_A249_V0.7111.00
332_L344_S0.7091.00
105_W443_V0.7081.00
279_P287_L0.7071.00
447_F450_M0.7071.00
77_M90_F0.7061.00
58_L62_V0.7041.00
37_I256_F0.7041.00
237_D243_P0.7031.00
331_F347_L0.7031.00
41_L260_S0.7031.00
444_W447_F0.7021.00
425_L428_M0.7011.00
123_G139_A0.7011.00
197_L200_Y0.6981.00
405_F408_L0.6971.00
390_L411_P0.6961.00
19_L22_G0.6961.00
440_L444_W0.6961.00
88_A92_Y0.6941.00
389_H393_R0.6921.00
29_Q245_A0.6921.00
67_A225_L0.6911.00
239_E404_Q0.6891.00
26_R159_E0.6881.00
439_I449_F0.6871.00
337_R342_I0.6871.00
396_M399_Q0.6851.00
123_G135_T0.6831.00
439_I447_F0.6801.00
439_I448_L0.6791.00
284_F287_L0.6781.00
436_L445_I0.6771.00
278_S281_V0.6771.00
158_G162_F0.6761.00
432_D436_L0.6761.00
317_R320_F0.6751.00
393_R410_Y0.6751.00
74_L385_I0.6741.00
350_A353_S0.6741.00
114_V374_V0.6741.00
288_D291_V0.6721.00
116_M370_L0.6721.00
150_N345_L0.6711.00
233_A320_F0.6711.00
113_L373_L0.6691.00
388_A392_F0.6691.00
195_D199_R0.6681.00
410_Y413_G0.6661.00
176_I260_S0.6661.00
438_A443_V0.6651.00
441_L444_W0.6651.00
319_L347_L0.6651.00
150_N313_Y0.6641.00
22_G26_R0.6631.00
57_L61_G0.6611.00
419_A422_G0.6581.00
140_A357_L0.6571.00
114_V118_E0.6571.00
192_A196_N0.6531.00
208_W212_I0.6531.00
58_L61_G0.6531.00
84_S320_F0.6531.00
129_W297_N0.6531.00
179_G183_L0.6521.00
248_Q251_Y0.6521.00
196_N200_Y0.6511.00
376_A425_L0.6481.00
94_Y391_R0.6471.00
29_Q32_A0.6471.00
56_V261_L0.6461.00
69_L417_C0.6451.00
110_M378_L0.6451.00
75_G79_V0.6431.00
38_G257_Y0.6431.00
34_G165_A0.6421.00
192_A198_W0.6411.00
316_S344_S0.6411.00
88_A104_G0.6411.00
156_L159_E0.6401.00
144_I147_N0.6381.00
128_Y131_P0.6381.00
35_G311_G0.6371.00
303_A306_S0.6331.00
183_L263_V0.6321.00
312_V316_S0.6311.00
136_W139_A0.6271.00
35_G310_S0.6271.00
279_P282_M0.6271.00
60_Y221_S0.6271.00
229_G246_V0.6271.00
146_I305_L0.6261.00
199_R202_G0.6251.00
72_R413_G0.6241.00
158_G309_N0.6241.00
167_I299_V0.6241.00
409_L414_N0.6231.00
252_R256_F0.6221.00
26_R29_Q0.6221.00
122_A126_M0.6211.00
116_M119_L0.6201.00
259_G263_V0.6201.00
94_Y392_F0.6191.00
377_T381_N0.6181.00
424_I428_M0.6181.00
87_F226_E0.6151.00
212_I427_L0.6151.00
407_A410_Y0.6141.00
54_P265_L0.6141.00
153_N156_L0.6121.00
129_W298_F0.6111.00
434_M441_L0.6101.00
235_A242_I0.6091.00
45_I261_L0.6091.00
435_R443_V0.6071.00
432_D439_I0.6061.00
128_Y297_N0.6061.00
47_P368_G0.6051.00
78_V242_I0.6051.00
439_I451_A0.6051.00
44_G371_M0.6021.00
242_I246_V0.6021.00
18_T21_R0.6011.00
167_I171_A0.6001.00
95_W388_A0.6001.00
407_A414_N0.6001.00
62_V215_L0.6001.00
223_G226_E0.5981.00
291_V294_S0.5971.00
154_V231_T0.5961.00
234_E341_P0.5961.00
71_M225_L0.5941.00
238_P241_S0.5941.00
260_S280_F0.5941.00
441_L448_L0.5931.00
433_D438_A0.5911.00
252_R255_L0.5901.00
323_S332_L0.5891.00
442_P445_I0.5891.00
111_F311_G0.5891.00
383_I425_L0.5881.00
57_L258_I0.5881.00
210_G213_L0.5871.00
435_R447_F0.5871.00
411_P414_N0.5871.00
106_N381_N0.5861.00
437_S442_P0.5861.00
438_A448_L0.5841.00
48_A218_I0.5841.00
192_A197_L0.5841.00
143_F353_S0.5821.00
126_M142_F0.5821.00
437_S446_V0.5821.00
284_F289_S0.5801.00
418_I421_L0.5801.00
151_L345_L0.5781.00
78_V229_G0.5781.00
379_L421_L0.5781.00
433_D450_M0.5771.00
73_Q417_C0.5761.00
315_N319_L0.5761.00
178_F182_L0.5751.00
230_I314_S0.5751.00
33_L165_A0.5751.00
63_A219_M0.5741.00
335_V338_R0.5741.00
436_L446_V0.5741.00
165_A168_K0.5741.00
77_M94_Y0.5711.00
194_I266_A0.5711.00
260_S264_L0.5711.00
48_A52_A0.5701.00
162_F166_L0.5691.00
435_R446_V0.5661.00
87_F230_I0.5651.00
125_Y300_I0.5651.00
184_F266_A0.5651.00
142_F308_Y0.5651.00
201_G204_F0.5631.00
342_I345_L0.5631.00
435_R449_F0.5611.00
433_D448_L0.5601.00
118_E308_Y0.5581.00
96_G100_G0.5561.00
60_Y261_L0.5561.00
86_S229_G0.5551.00
415_Y418_I0.5521.00
368_G371_M0.5511.00
63_A222_F0.5491.00
437_S450_M0.5481.00
157_Y313_Y0.5481.00
417_C420_F0.5481.00
298_F302_V0.5471.00
205_A270_W0.5471.00
88_A100_G0.5471.00
91_A100_G0.5461.00
437_S447_F0.5461.00
35_G227_L0.5461.00
184_F192_A0.5451.00
145_I149_V0.5451.00
378_L381_N0.5451.00
51_M213_L0.5441.00
407_A413_G0.5441.00
156_L160_T0.5441.00
114_V117_A0.5431.00
103_S381_N0.5431.00
436_L450_M0.5431.00
112_V348_S0.5421.00
353_S356_V0.5411.00
30_L165_A0.5401.00
441_L446_V0.5401.00
421_L425_L0.5391.00
163_W166_L0.5391.00
223_G374_V0.5391.00
283_I287_L0.5381.00
71_M75_G0.5371.00
38_G168_K0.5371.00
116_M355_V0.5371.00
70_I226_E0.5351.00
433_D444_W0.5351.00
142_F146_I0.5341.00
55_A58_L0.5331.00
435_R442_P0.5321.00
319_L323_S0.5311.00
57_L60_Y0.5301.00
119_L123_G0.5291.00
24_H155_R0.5281.00
228_I242_I0.5281.00
252_R259_G0.5271.00
295_A299_V0.5271.00
331_F335_V0.5261.00
170_L173_I0.5261.00
76_E408_L0.5261.00
263_V266_A0.5241.00
427_L431_M0.5241.00
31_I34_G0.5241.00
438_A447_F0.5241.00
410_Y415_Y0.5241.00
317_R341_P0.5241.00
194_I199_R0.5231.00
73_Q407_A0.5211.00
443_V449_F0.5211.00
403_T406_K0.5201.00
118_E304_S0.5201.00
235_A245_A0.5191.00
41_L44_G0.5191.00
239_E244_K0.5191.00
60_Y257_Y0.5191.00
390_L418_I0.5181.00
163_W167_I0.5181.00
281_V285_H0.5171.00
52_A55_A0.5161.00
110_M377_T0.5161.00
347_L351_I0.5161.00
54_P270_W0.5151.00
100_G104_G0.5141.00
441_L447_F0.5121.00
32_A36_A0.5121.00
142_F305_L0.5121.00
317_R335_V0.5111.00
28_I228_I0.5111.00
112_V355_V0.5091.00
135_T139_A0.5091.00
240_K243_P0.5091.00
437_S440_L0.5091.00
234_E335_V0.5071.00
141_A144_I0.5071.00
147_N312_V0.5061.00
68_F251_Y0.5031.00
167_I302_V0.5011.00
442_P448_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.8886 100 0.284 Contact Map
4djkA 2 0.8952 100 0.341 Contact Map
3giaA 1 0.9039 100 0.35 Contact Map
3dh4A 3 0.9127 99.2 0.834 Contact Map
2xq2A 2 0.9127 99.1 0.84 Contact Map
2jlnA 1 0.8886 98.9 0.851 Contact Map
4wgvA 2 0.8057 97.9 0.89 Contact Map
4us3A 1 0.8537 97.2 0.905 Contact Map
2a65A 2 0.9192 96.8 0.91 Contact Map
4xp4A 1 0.9214 96.7 0.911 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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