GREMLIN Database
MSBB - Lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase
UniProt: P24205 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10614
Length: 323 (283)
Sequences: 4326 (3076)
Seq/√Len: 182.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
279_R283_E3.9471.00
118_Q259_T3.8881.00
116_D259_T3.6811.00
118_Q261_Q3.3551.00
252_D259_T2.9401.00
88_E294_E2.8471.00
67_L86_V2.8211.00
67_L83_E2.8191.00
78_S81_E2.7811.00
221_D279_R2.7581.00
221_D226_Y2.7471.00
122_I264_P2.7231.00
53_R91_A2.7131.00
120_L124_E2.6081.00
77_R81_E2.5791.00
283_E286_E2.5671.00
76_E290_G2.4691.00
70_L82_R2.4591.00
124_E128_R2.3211.00
119_G122_I2.3181.00
48_L94_P2.3091.00
229_T282_N2.2621.00
71_S82_R2.2601.00
197_S202_Y2.1271.00
158_A202_Y2.1171.00
40_P43_F2.1101.00
275_H279_R2.0821.00
263_R284_E2.0761.00
72_L225_T2.0661.00
121_E125_E2.0611.00
77_R85_I2.0601.00
65_R301_K2.0331.00
122_I125_E2.0001.00
223_F286_E1.9901.00
246_P263_R1.9511.00
250_I259_T1.9311.00
68_I71_S1.9271.00
250_I292_R1.8951.00
71_S79_E1.8621.00
74_F77_R1.8571.00
163_N186_A1.8461.00
246_P265_P1.8091.00
49_A91_A1.7921.00
99_M251_Y1.7911.00
171_Y175_T1.7711.00
131_E243_R1.7711.00
219_F226_Y1.7651.00
116_D257_R1.7411.00
273_D276_T1.7081.00
66_A86_V1.7021.00
220_V279_R1.6981.00
220_V282_N1.6371.00
138_P285_V1.6361.00
218_E278_A1.6181.00
126_M245_V1.5881.00
56_G63_R1.5681.00
250_I261_Q1.5451.00
284_E287_I1.5211.00
125_E129_N1.5151.00
122_I245_V1.5141.00
195_I199_R1.5011.00
84_A88_E1.4661.00
81_E84_A1.4491.00
110_K114_R1.4461.00
245_V262_V1.4331.00
158_A197_S1.4241.00
67_L71_S1.4081.00
263_R287_I1.4031.00
225_T306_R1.3871.00
194_F204_G1.3781.00
66_A89_M1.3751.00
280_R284_E1.3691.00
48_L52_G1.3661.00
81_E85_I1.3651.00
162_H165_G1.3641.00
34_A38_L1.3611.00
131_E241_R1.3491.00
183_R193_P1.3371.00
49_A95_Q1.3361.00
67_L82_R1.3321.00
64_R68_I1.3261.00
108_P112_Q1.3171.00
286_E290_G1.3051.00
77_R82_R1.2981.00
221_D283_E1.2851.00
54_F58_L1.2841.00
42_K46_P1.2651.00
174_N178_R1.2621.00
44_R98_A1.2571.00
223_F290_G1.2441.00
246_P266_M1.2381.00
134_I242_A1.2321.00
73_C303_L1.2311.00
253_G256_H1.2231.00
135_F247_L1.2191.00
219_F228_A1.2161.00
56_G87_D1.2091.00
248_F288_F1.2091.00
170_D174_N1.1901.00
274_D278_A1.1841.00
280_R283_E1.1831.00
285_V289_V1.1811.00
252_D257_R1.1781.00
106_R110_K1.1771.00
269_L272_A1.1721.00
125_E128_R1.1671.00
196_Q200_Q1.1561.00
160_M194_F1.1471.00
234_G278_A1.1461.00
63_R67_L1.1451.00
133_V203_W1.1451.00
183_R202_Y1.1401.00
248_F263_R1.1311.00
112_Q152_S1.1291.00
271_E277_I1.1291.00
211_D305_T1.1251.00
237_M244_V1.1221.00
251_Y295_Q1.1201.00
60_K63_R1.1191.00
133_V243_R1.1181.00
50_R54_F1.1151.00
85_I294_E1.1141.00
56_G86_V1.1111.00
46_P50_R1.1071.00
253_G257_R1.1021.00
41_P45_D1.0981.00
219_F307_K1.0921.00
161_F184_L1.0851.00
218_E275_H1.0851.00
261_Q291_P1.0771.00
210_Q300_L1.0641.00
46_P49_A1.0641.00
158_A185_H1.0561.00
124_E127_R1.0481.00
287_I290_G1.0471.00
193_P196_Q1.0441.00
160_M206_Y1.0431.00
122_I126_M1.0311.00
60_K64_R1.0291.00
226_Y307_K1.0281.00
246_P284_E1.0271.00
63_R90_F1.0251.00
116_D252_D1.0190.99
272_A277_I1.0170.99
30_V34_A1.0140.99
292_R295_Q1.0080.99
248_F284_E1.0040.99
238_K277_I1.0010.99
66_A299_I1.0000.99
74_F82_R0.9980.99
136_L281_M0.9920.99
45_D95_Q0.9910.99
42_K45_D0.9900.99
92_T95_Q0.9720.99
227_K302_L0.9660.99
272_A276_T0.9620.99
122_I265_P0.9550.99
70_L86_V0.9510.99
129_N243_R0.9510.99
208_P233_I0.9480.99
192_K195_I0.9480.99
147_A159_A0.9440.99
30_V172_V0.9390.99
288_F291_P0.9340.99
53_R87_D0.9310.99
189_D193_P0.9260.99
132_K242_A0.9240.99
93_A299_I0.9230.99
130_N201_G0.9230.99
34_A37_A0.9230.99
263_R288_F0.9100.99
164_Q173_W0.9100.99
135_F203_W0.9090.99
43_F46_P0.9090.99
283_E287_I0.9090.99
298_W302_L0.9070.99
73_C223_F0.9060.99
57_R83_E0.8950.99
126_M129_N0.8910.99
68_I72_L0.8790.99
44_R102_E0.8620.98
57_R87_D0.8600.98
219_F305_T0.8600.98
210_Q298_W0.8590.98
89_M299_I0.8580.98
218_E231_P0.8530.98
92_T294_E0.8430.98
40_P46_P0.8430.98
127_R201_G0.8430.98
39_T43_F0.8410.98
70_L77_R0.8380.98
144_D177_R0.8350.98
62_S300_L0.8340.98
138_P208_P0.8260.98
114_R257_R0.8240.98
143_V207_L0.8210.98
125_E264_P0.8190.98
69_N289_V0.8190.98
107_G110_K0.8180.98
126_M243_R0.8170.98
210_Q297_T0.8160.98
89_M93_A0.8150.98
140_G295_Q0.8140.98
276_T280_R0.8130.98
158_A183_R0.8130.98
284_E288_F0.8060.97
212_H230_L0.7970.97
218_E279_R0.7960.97
211_D219_F0.7910.97
45_D49_A0.7910.97
117_W120_L0.7840.97
227_K303_L0.7790.97
221_D224_A0.7770.97
136_L208_P0.7750.97
56_G83_E0.7740.97
183_R197_S0.7720.97
243_R265_P0.7680.96
117_W149_L0.7680.96
238_K274_D0.7610.96
276_T279_R0.7600.96
296_Y303_L0.7570.96
254_K257_R0.7540.96
70_L85_I0.7510.96
251_Y258_L0.7500.96
195_I239_V0.7480.96
210_Q302_L0.7460.96
33_M101_A0.7460.96
263_R291_P0.7450.96
233_I281_M0.7440.96
264_P267_D0.7440.96
268_D271_E0.7440.96
238_K272_A0.7410.96
217_S228_A0.7380.96
270_L277_I0.7340.95
110_K113_P0.7320.95
92_T251_Y0.7320.95
214_P305_T0.7310.95
26_A30_V0.7190.95
277_I280_R0.7180.95
72_L303_L0.7160.95
140_G288_F0.7150.95
68_I225_T0.7140.95
63_R86_V0.7120.95
132_K198_V0.7110.95
59_G62_S0.7110.95
220_V278_A0.7080.95
56_G67_L0.7040.94
50_R53_R0.7030.94
269_L277_I0.6980.94
57_R60_K0.6960.94
52_G56_G0.6930.94
62_S65_R0.6930.94
69_N223_F0.6870.94
219_F306_R0.6870.94
167_P171_Y0.6860.94
94_P97_M0.6830.93
79_E83_E0.6810.93
119_G264_P0.6810.93
142_A296_Y0.6790.93
287_I291_P0.6770.93
52_G91_A0.6760.93
38_L43_F0.6760.93
138_P281_M0.6740.93
88_E91_A0.6740.93
228_A305_T0.6730.93
192_K235_R0.6720.93
185_H197_S0.6710.93
65_R300_L0.6670.93
39_T42_K0.6650.92
234_G238_K0.6650.92
300_L304_K0.6640.92
37_A105_I0.6630.92
194_F236_L0.6610.92
26_A168_V0.6590.92
223_F289_V0.6580.92
53_R57_R0.6580.92
140_G292_R0.6570.92
93_A297_T0.6560.92
27_W31_A0.6550.92
193_P197_S0.6550.92
56_G90_F0.6540.92
212_H228_A0.6500.92
229_T302_L0.6500.92
65_R69_N0.6490.92
161_F186_A0.6480.91
41_P102_E0.6450.91
39_T47_I0.6450.91
234_G277_I0.6440.91
156_K202_Y0.6440.91
164_Q170_D0.6400.91
278_A282_N0.6400.91
233_I244_V0.6370.91
53_R56_G0.6340.91
265_P280_R0.6340.91
83_E86_V0.6330.91
146_P205_Y0.6310.90
134_I240_C0.6290.90
95_Q251_Y0.6260.90
197_S204_G0.6260.90
35_G38_L0.6260.90
246_P288_F0.6240.90
123_I135_F0.6220.90
134_I206_Y0.6210.90
40_P44_R0.6210.90
143_V205_Y0.6160.89
248_F291_P0.6150.89
55_A90_F0.6150.89
217_S220_V0.6130.89
28_L31_A0.6110.89
161_F170_D0.6110.89
150_M157_M0.6110.89
117_W262_V0.6100.89
237_M243_R0.6100.89
163_N170_D0.6090.89
142_A210_Q0.6080.89
222_F289_V0.6080.89
92_T295_Q0.6070.89
109_E112_Q0.6070.89
211_D228_A0.6070.89
137_V205_Y0.6070.89
108_P148_M0.6070.89
234_G269_L0.6050.88
137_V146_P0.6040.88
121_E124_E0.6030.88
126_M133_V0.6010.88
144_D205_Y0.6000.88
27_W30_V0.6000.88
120_L123_I0.5990.88
235_R239_V0.5980.88
156_K183_R0.5950.88
82_R85_I0.5950.88
230_L233_I0.5950.88
95_Q99_M0.5940.88
93_A96_A0.5940.88
96_A137_V0.5920.87
178_R184_L0.5890.87
208_P281_M0.5890.87
123_I127_R0.5870.87
112_Q153_Q0.5870.87
162_H212_H0.5870.87
50_R58_L0.5860.87
73_C225_T0.5790.86
247_L262_V0.5790.86
136_L233_I0.5790.86
64_R67_L0.5780.86
197_S200_Q0.5770.86
144_D159_A0.5760.86
35_G39_T0.5750.86
132_K204_G0.5750.86
79_E82_R0.5730.86
220_V275_H0.5730.86
252_D256_H0.5720.86
162_H298_W0.5720.86
159_A184_L0.5690.85
89_M297_T0.5680.85
250_I291_P0.5670.85
138_P248_F0.5670.85
52_G57_R0.5660.85
119_G262_V0.5650.85
45_D48_L0.5640.85
141_W249_P0.5620.85
69_N73_C0.5600.84
124_E153_Q0.5590.84
52_G94_P0.5580.84
72_L223_F0.5570.84
266_M280_R0.5560.84
75_P82_R0.5560.84
109_E113_P0.5530.84
90_F93_A0.5510.83
49_A53_R0.5510.83
198_V204_G0.5500.83
69_N177_R0.5500.83
94_P98_A0.5490.83
225_T305_T0.5490.83
41_P99_M0.5470.83
147_A184_L0.5450.83
80_A84_A0.5450.83
87_D91_A0.5430.82
198_V236_L0.5420.82
31_A35_G0.5400.82
160_M232_A0.5390.82
160_M190_G0.5370.82
198_V242_A0.5360.82
47_I50_R0.5340.81
78_S82_R0.5340.81
61_S65_R0.5340.81
249_P260_I0.5340.81
65_R68_I0.5320.81
223_F281_M0.5320.81
231_P235_R0.5310.81
103_L205_Y0.5290.81
204_G236_L0.5280.81
268_D277_I0.5270.81
211_D304_K0.5270.81
123_I150_M0.5260.80
119_G245_V0.5250.80
51_L88_E0.5240.80
117_W260_I0.5240.80
61_S64_R0.5240.80
41_P44_R0.5190.80
118_Q252_D0.5190.80
185_H193_P0.5190.80
126_M262_V0.5190.80
225_T303_L0.5160.79
211_D230_L0.5150.79
132_K243_R0.5150.79
37_A40_P0.5150.79
123_I133_V0.5140.79
192_K216_H0.5100.78
66_A90_F0.5090.78
214_P308_P0.5080.78
206_Y232_A0.5080.78
231_P274_D0.5080.78
198_V240_C0.5070.78
131_E267_D0.5070.78
206_Y233_I0.5060.78
133_V245_V0.5040.78
234_G303_L0.5040.78
208_P232_A0.5030.77
171_Y174_N0.5020.77
102_E110_K0.5010.77
134_I185_H0.5010.77
221_D286_E0.5000.77
47_I98_A0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1iuqA 1 0.8916 98.2 0.879 Contact Map
3cg0A 4 0.3839 22.8 0.96 Contact Map
2lpmA 1 0.3808 21.6 0.96 Contact Map
3f6pA 1 0.3684 15.1 0.963 Contact Map
4nicA 2 0.3591 14.7 0.963 Contact Map
3j61Z 1 0.3344 14.5 0.963 Contact Map
4ujrM 1 0.3313 14.2 0.963 Contact Map
1xhfA 2 0.3746 13.6 0.964 Contact Map
3to5A 1 0.3839 13.3 0.964 Contact Map
4igaA 1 0.356 13 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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