GREMLIN Database
YJIA - Uncharacterized GTP-binding protein YjiA
UniProt: P24203 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10021
Length: 318 (301)
Sequences: 5739 (3621)
Seq/√Len: 208.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
170_H184_T5.9361.00
306_E310_R5.1341.00
156_L185_V4.4631.00
132_A163_A3.8591.00
229_V314_A3.2271.00
132_A157_L3.0701.00
158_T185_V2.9701.00
161_D186_T2.8591.00
310_R314_A2.7731.00
129_L158_T2.6491.00
155_I173_L2.6111.00
243_V312_A2.5821.00
181_P194_L2.5561.00
288_W293_P2.4701.00
170_H174_A2.4621.00
94_L121_Y2.4471.00
236_D239_E2.4451.00
177_N180_A2.4051.00
258_Y273_F2.4041.00
23_H189_D2.3211.00
31_Y93_R2.2891.00
9_L21_L2.2861.00
140_N172_R2.2241.00
305_P308_E2.2121.00
3_P122_L2.2021.00
23_H27_E2.1911.00
24_I95_V2.1281.00
32_K92_D2.1171.00
34_A80_L2.1161.00
160_T184_T2.0651.00
240_V264_I2.0621.00
77_L94_L2.0171.00
307_E311_A1.9911.00
79_D83_N1.9431.00
230_E296_T1.8871.00
131_D159_K1.8831.00
185_V188_G1.8281.00
44_S59_T1.8021.00
227_I309_I1.8001.00
167_E171_E1.7911.00
4_I94_L1.7451.00
230_E294_H1.7441.00
39_E44_S1.7261.00
78_L82_D1.7141.00
25_L35_V1.7041.00
174_A182_V1.7031.00
81_L121_Y1.6931.00
10_T128_A1.6841.00
15_A129_L1.6811.00
10_T126_V1.6791.00
44_S47_D1.6601.00
237_I241_S1.6501.00
7_T124_D1.6481.00
236_D265_D1.6471.00
24_I192_L1.6261.00
154_R181_P1.6251.00
169_L173_L1.5901.00
20_L129_L1.5881.00
241_S245_E1.5861.00
135_A149_V1.5831.00
103_D147_S1.5721.00
191_D194_L1.5661.00
234_P263_W1.5211.00
125_G154_R1.5141.00
255_L299_F1.5051.00
135_A169_L1.4901.00
20_L188_G1.4831.00
227_I310_R1.4821.00
22_R26_N1.4791.00
258_Y275_G1.4751.00
7_T93_R1.4731.00
152_A155_I1.4601.00
186_T189_D1.4551.00
51_G54_A1.4501.00
232_D294_H1.4451.00
99_T102_A1.4421.00
149_V155_I1.4381.00
64_C67_C1.4071.00
77_L121_Y1.4031.00
108_I126_V1.3851.00
158_T187_H1.3791.00
33_I93_R1.3751.00
258_Y299_F1.3521.00
23_H26_N1.3451.00
187_H281_S1.3411.00
225_S306_E1.3371.00
229_V313_F1.3351.00
133_V162_V1.3311.00
227_I306_E1.3281.00
125_G198_T1.3181.00
34_A91_F1.3101.00
43_V228_V1.3071.00
272_L283_D1.3051.00
211_K214_F1.3021.00
254_K302_I1.2921.00
138_Q141_Q1.2921.00
170_H182_V1.2771.00
65_I96_I1.2611.00
157_L184_T1.2611.00
240_V262_L1.2581.00
308_E312_A1.2481.00
133_V279_L1.2421.00
60_L69_R1.2411.00
98_C107_I1.2391.00
40_F226_S1.2331.00
275_G280_Y1.2291.00
44_S61_T1.2261.00
264_I271_L1.2141.00
267_E271_L1.2101.00
39_E47_D1.2061.00
152_A177_N1.2051.00
229_V235_V1.2001.00
83_N89_I1.1991.00
307_E310_R1.1901.00
37_E50_I1.1861.00
149_V173_L1.1751.00
108_I123_L1.1681.00
167_E170_H1.1361.00
158_T188_G1.1291.00
262_L295_S1.1151.00
139_M146_Q1.1031.00
216_F219_D1.0991.00
235_V240_V1.0971.00
231_L314_A1.0911.00
160_T186_T1.0881.00
81_L120_R1.0871.00
137_E141_Q1.0871.00
301_G304_L1.0861.00
212_P215_H1.0831.00
271_L284_W1.0691.00
73_L96_I1.0641.00
165_E184_T1.0601.00
223_D303_Q1.0531.00
179_R205_E1.0391.00
128_A152_A1.0381.00
23_H188_G1.0331.00
8_L111_F1.0311.00
71_N75_D1.0301.00
202_M205_E1.0281.00
172_R175_R1.0271.00
116_V119_Q1.0271.00
130_V135_A1.0201.00
237_I264_I1.0181.00
154_R183_Y1.0141.00
163_A169_L1.0101.00
75_D79_D1.0061.00
49_L272_L1.0001.00
171_E175_R0.9991.00
156_L190_I0.9911.00
24_I195_L0.9901.00
261_M272_L0.9881.00
240_V280_Y0.9771.00
246_N312_A0.9751.00
68_S99_T0.9751.00
263_W293_P0.9731.00
55_T58_K0.9701.00
211_K215_H0.9701.00
311_A314_A0.9671.00
238_S242_R0.9581.00
206_N209_S0.9561.00
129_L188_G0.9561.00
65_I73_L0.9541.00
36_I94_L0.9380.99
218_A221_Q0.9320.99
288_W291_E0.9310.99
308_E311_A0.9300.99
212_P216_F0.9280.99
72_E75_D0.9270.99
6_V94_L0.9260.99
206_N210_T0.9220.99
36_I76_A0.9210.99
264_I267_E0.9170.99
40_F101_M0.9120.99
263_W288_W0.9100.99
254_K303_Q0.9050.99
31_Y193_G0.9020.99
37_E44_S0.8910.99
78_L120_R0.8910.99
167_E184_T0.8900.99
272_L285_D0.8890.99
7_T127_I0.8860.99
133_V163_A0.8810.99
124_D199_N0.8760.99
124_D200_G0.8750.99
136_D168_K0.8700.99
48_Q296_T0.8630.99
242_R246_N0.8580.99
156_L183_Y0.8570.99
22_R50_I0.8550.99
6_V96_I0.8510.99
98_C102_A0.8500.99
37_E46_D0.8480.99
55_T72_E0.8460.99
76_A79_D0.8460.99
126_V153_D0.8430.99
214_F217_I0.8430.99
169_L172_R0.8410.99
21_L95_V0.8390.99
81_L94_L0.8390.99
231_L310_R0.8340.99
183_Y190_I0.8330.99
130_V155_I0.8280.99
39_E102_A0.8250.99
40_F102_A0.8220.99
135_A145_A0.8210.98
124_D196_F0.8200.98
56_Q83_N0.8190.98
39_E99_T0.8170.98
20_L156_L0.8150.98
6_V111_F0.8150.98
22_R41_G0.8140.98
4_I81_L0.8140.98
240_V244_M0.8120.98
31_Y92_D0.8100.98
155_I180_A0.8060.98
136_D172_R0.8030.98
158_T186_T0.8020.98
27_E192_L0.7890.98
168_K171_E0.7870.98
161_D187_H0.7860.98
7_T125_G0.7850.98
237_I266_G0.7840.98
8_L126_V0.7790.98
236_D266_G0.7790.98
80_L91_F0.7780.98
255_L258_Y0.7780.98
215_H218_A0.7770.98
46_D50_I0.7750.98
204_E208_V0.7750.98
49_L261_M0.7750.98
227_I299_F0.7740.98
223_D226_S0.7700.98
62_N111_F0.7700.98
155_I182_V0.7690.98
161_D188_G0.7680.98
43_V46_D0.7680.98
196_F199_N0.7670.98
286_R291_E0.7630.98
183_Y194_L0.7600.98
267_E284_W0.7600.98
83_N91_F0.7590.97
12_F256_L0.7580.97
260_G297_M0.7580.97
232_D292_K0.7560.97
207_V210_T0.7550.97
25_L33_I0.7530.97
128_A148_Q0.7510.97
26_N29_H0.7490.97
62_N66_C0.7460.97
286_R289_G0.7450.97
124_D197_N0.7440.97
58_K76_A0.7420.97
289_G292_K0.7410.97
262_L273_F0.7400.97
22_R49_L0.7380.97
78_L81_L0.7370.97
157_L182_V0.7340.97
144_I147_S0.7260.97
185_V190_I0.7210.97
117_L121_Y0.7190.97
128_A155_I0.7170.96
299_F313_F0.7150.96
157_L160_T0.7150.96
102_A107_I0.7130.96
97_E100_G0.7090.96
135_A139_M0.7070.96
60_L76_A0.7060.96
77_L111_F0.7040.96
252_A255_L0.7040.96
105_G109_Q0.7030.96
160_T163_A0.7020.96
31_Y197_N0.7010.96
263_W270_R0.7010.96
304_L309_I0.6990.96
24_I33_I0.6980.96
91_F94_L0.6950.96
270_R285_D0.6920.96
78_L116_V0.6900.96
192_L195_L0.6880.96
28_Q31_Y0.6860.95
13_L16_G0.6800.95
12_F148_Q0.6750.95
290_D293_P0.6750.95
203_L207_V0.6740.95
37_E45_V0.6740.95
38_N41_G0.6710.95
131_D134_H0.6640.95
273_F297_M0.6640.95
63_G67_C0.6620.95
159_K162_V0.6610.94
203_L209_S0.6610.94
204_E207_V0.6550.94
257_R260_G0.6540.94
205_E208_V0.6510.94
33_I95_V0.6510.94
215_H219_D0.6510.94
44_S118_C0.6510.94
45_V48_Q0.6500.94
273_F282_A0.6480.94
281_S284_W0.6470.94
228_V231_L0.6470.94
14_G17_K0.6470.94
130_V169_L0.6460.94
157_L170_H0.6450.94
47_D59_T0.6450.94
39_E59_T0.6450.94
93_R124_D0.6440.94
195_L199_N0.6420.94
11_G17_K0.6410.94
64_C68_S0.6390.93
132_A169_L0.6370.93
29_H33_I0.6360.93
20_L185_V0.6340.93
105_G147_S0.6300.93
63_G104_P0.6300.93
231_L235_V0.6290.93
139_M172_R0.6280.93
23_H192_L0.6280.93
136_D169_L0.6270.93
13_L38_N0.6270.93
167_E174_A0.6270.93
143_T146_Q0.6270.93
46_D57_I0.6240.93
157_L169_L0.6230.93
11_G14_G0.6230.93
134_H277_Q0.6230.93
130_V149_V0.6220.93
239_E243_V0.6190.92
37_E47_D0.6180.92
72_E110_T0.6180.92
122_L197_N0.6150.92
231_L313_F0.6150.92
13_L17_K0.6110.92
5_A122_L0.6110.92
231_L295_S0.6110.92
74_E113_S0.6110.92
83_N90_Q0.6090.92
144_I222_N0.6090.92
23_H190_I0.6090.92
63_G66_C0.6060.92
100_G259_K0.6040.91
10_T98_C0.6030.91
265_D268_P0.6010.91
181_P200_G0.6010.91
269_N284_W0.6000.91
205_E209_S0.5990.91
98_C153_D0.5980.91
5_A124_D0.5970.91
211_K217_I0.5960.91
10_T125_G0.5950.91
122_L199_N0.5940.91
23_H187_H0.5920.91
7_T153_D0.5900.90
194_L197_N0.5890.90
238_S241_S0.5870.90
45_V261_M0.5870.90
8_L123_L0.5860.90
211_K216_F0.5850.90
3_P119_Q0.5850.90
255_L304_L0.5820.90
34_A89_I0.5810.90
150_G275_G0.5780.90
245_E280_Y0.5770.89
154_R194_L0.5760.89
154_R195_L0.5750.89
270_R293_P0.5740.89
60_L70_S0.5730.89
203_L206_N0.5710.89
165_E170_H0.5710.89
79_D189_D0.5680.89
243_V281_S0.5670.89
127_I154_R0.5660.89
109_Q112_F0.5660.89
105_G112_F0.5650.88
213_R216_F0.5650.88
273_F280_Y0.5650.88
288_W295_S0.5630.88
237_I267_E0.5630.88
173_L184_T0.5630.88
60_L64_C0.5610.88
35_V38_N0.5600.88
23_H185_V0.5580.88
133_V137_E0.5560.88
39_E103_D0.5560.88
123_L126_V0.5550.88
4_I121_Y0.5510.87
13_L18_T0.5500.87
106_P110_T0.5480.87
45_V296_T0.5480.87
213_R217_I0.5470.87
109_Q113_S0.5460.87
192_L196_F0.5460.87
16_G19_T0.5440.87
8_L98_C0.5430.86
140_N168_K0.5420.86
244_M258_Y0.5390.86
260_G273_F0.5390.86
153_D200_G0.5380.86
232_D263_W0.5370.86
14_G18_T0.5350.86
171_E174_A0.5340.86
232_D235_V0.5320.85
156_L186_T0.5320.85
38_N66_C0.5320.85
81_L117_L0.5290.85
11_G16_G0.5290.85
33_I92_D0.5290.85
155_I247_L0.5280.85
82_D116_V0.5270.85
150_G176_I0.5260.85
238_S246_N0.5260.85
40_F99_T0.5260.85
9_L177_N0.5250.85
101_M224_I0.5250.85
197_N202_M0.5250.85
127_I156_L0.5250.85
106_P109_Q0.5220.84
29_H193_G0.5210.84
190_I195_L0.5210.84
199_N202_M0.5200.84
156_L184_T0.5200.84
299_F304_L0.5190.84
143_T147_S0.5190.84
202_M210_T0.5190.84
134_H138_Q0.5190.84
233_Y295_S0.5170.84
60_L67_C0.5170.84
215_H220_K0.5160.84
13_L100_G0.5160.84
168_K175_R0.5150.83
263_W295_S0.5130.83
71_N111_F0.5120.83
142_F158_T0.5110.83
146_Q176_I0.5110.83
18_T49_L0.5110.83
235_V239_E0.5110.83
271_L282_A0.5100.83
58_K62_N0.5100.83
47_D50_I0.5080.83
28_Q95_V0.5070.82
200_G203_L0.5070.82
138_Q145_A0.5060.82
282_A285_D0.5050.82
242_R245_E0.5050.82
233_Y263_W0.5050.82
65_I68_S0.5040.82
106_P126_V0.5030.82
275_G278_R0.5020.82
81_L116_V0.5020.82
219_D222_N0.5010.82
70_S280_Y0.5010.82
7_T195_L0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1nijA 1 0.9969 100 0.312 Contact Map
4ehxA 1 0.783 99.9 0.704 Contact Map
2wsmA 2 0.566 99.9 0.729 Contact Map
2hf9A 2 0.5818 99.9 0.737 Contact Map
4lpsA 1 0.6101 99.8 0.758 Contact Map
1xjcA 2 0.4465 99.8 0.759 Contact Map
4hi0E 2 0.5723 99.8 0.76 Contact Map
1yrbA 2 0.7296 99.8 0.766 Contact Map
4xc8A 2 0.8459 99.7 0.785 Contact Map
2qm8A 2 0.7956 99.7 0.798 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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