GREMLIN Database
MRR - Mrr restriction system protein
UniProt: P24202 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10612
Length: 304 (288)
Sequences: 681 (589)
Seq/√Len: 34.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
177_D302_Y5.3131.00
254_G273_D4.8761.00
85_A108_A4.6601.00
236_Y269_M4.4621.00
5_T8_K4.0611.00
229_R233_Q3.5351.00
195_G198_G3.4301.00
232_L249_F3.3361.00
73_Q81_C3.2681.00
226_T256_T3.2051.00
241_G262_F2.9291.00
231_E234_A2.8811.00
40_D43_Q2.8371.00
89_W101_E2.8261.00
35_D44_R2.8001.00
19_T24_A2.7521.00
64_D68_R2.7131.00
233_Q262_F2.7051.00
166_V170_R2.6801.00
15_R36_A2.6791.00
163_L174_I2.5741.00
52_Q57_N2.5671.00
34_A55_Y2.5271.00
67_K74_S2.4851.00
230_P233_Q2.4621.00
226_T254_G2.3730.99
231_E249_F2.3390.99
225_N253_S2.3210.99
236_Y262_F2.2500.99
285_E296_P2.2480.99
200_G242_Q2.1960.99
152_R283_E2.1190.99
164_L224_Q2.1140.99
65_R109_F2.0910.99
84_P88_D2.0570.98
74_S80_W2.0410.98
240_A268_G2.0380.98
156_A279_H2.0280.98
210_K283_E2.0160.98
159_V278_V1.9220.98
11_E15_R1.8980.97
17_L29_V1.8780.97
155_V282_I1.8780.97
179_L218_V1.8770.97
290_S297_K1.8500.97
71_L89_W1.8330.97
236_Y240_A1.8120.97
85_A88_D1.8100.97
230_P234_A1.8060.97
9_F55_Y1.8020.96
106_A110_V1.7860.96
83_T86_G1.7650.96
198_G258_Q1.7310.96
229_R262_F1.6600.94
180_H191_L1.6580.94
33_A55_Y1.6000.93
223_W231_E1.5980.93
6_Y99_E1.5970.93
233_Q236_Y1.5380.92
233_Q241_G1.5090.91
33_A59_A1.4990.91
76_S79_K1.4980.91
175_V250_I1.4790.90
234_A262_F1.4700.90
285_E294_K1.4700.90
207_S215_K1.4590.89
229_R241_G1.4530.89
176_L193_R1.4490.89
98_T101_E1.4080.88
9_F12_P1.3850.87
13_V62_A1.3630.86
156_A282_I1.3550.86
31_E44_R1.3430.85
184_Y212_G1.3300.85
207_S276_R1.3280.84
213_L248_V1.3090.84
5_T10_I1.2980.83
234_A238_A1.2860.82
199_D203_D1.2810.82
209_D212_G1.2780.82
9_F33_A1.2720.82
223_W234_A1.2590.81
243_K267_E1.2590.81
32_A36_A1.2450.80
289_S300_M1.2390.80
229_R234_A1.2220.79
46_K54_V1.2200.79
159_V163_L1.2190.79
13_V63_H1.2040.78
7_D10_I1.2000.78
162_N300_M1.1950.78
100_Q103_N1.1930.77
109_F112_V1.1880.77
210_K223_W1.1830.77
6_Y60_G1.1800.77
6_Y65_R1.1770.76
194_V198_G1.1630.76
30_H56_K1.1570.75
164_L260_R1.1560.75
243_K266_V1.1560.75
16_Y32_A1.1550.75
276_R279_H1.1500.75
68_R112_V1.1480.75
17_L80_W1.1310.73
21_P24_A1.1250.73
13_V29_V1.1210.73
68_R115_K1.1190.73
163_L166_V1.1150.72
176_L218_V1.1130.72
276_R280_L1.1050.72
226_T273_D1.1030.72
15_R18_A1.0940.71
46_K50_S1.0860.70
206_I209_D1.0760.70
173_V177_D1.0730.69
215_K298_L1.0590.68
214_E246_R1.0500.68
85_A105_L1.0430.67
178_V182_L1.0270.66
99_E113_K1.0250.66
182_L209_D1.0210.66
89_W105_L1.0140.65
47_V53_L1.0130.65
6_Y109_F1.0090.65
6_Y113_K1.0040.64
176_L191_L1.0040.64
55_Y59_A0.9950.64
151_L295_V0.9950.64
228_G233_Q0.9940.63
236_Y241_G0.9880.63
248_V253_S0.9730.62
236_Y302_Y0.9720.62
204_G235_F0.9670.61
29_V72_S0.9650.61
245_K302_Y0.9540.60
222_R244_A0.9540.60
92_S104_H0.9520.60
164_L202_I0.9500.60
242_Q265_S0.9480.60
156_A270_V0.9480.60
48_I57_N0.9460.60
257_S261_D0.9420.59
206_I212_G0.9420.59
169_S195_G0.9410.59
11_E89_W0.9410.59
229_R258_Q0.9400.59
174_I281_M0.9390.59
25_A28_D0.9350.59
84_P87_F0.9350.59
208_L246_R0.9250.58
175_V220_A0.9250.58
17_L72_S0.9250.58
26_A80_W0.9240.58
116_S151_L0.9240.58
63_H80_W0.9120.57
201_G221_K0.9100.57
257_S260_R0.9070.56
29_V80_W0.8940.55
13_V33_A0.8900.55
53_L56_K0.8870.55
238_A268_G0.8780.54
230_P288_V0.8670.53
207_S210_K0.8520.52
199_D221_K0.8520.52
13_V59_A0.8500.51
258_Q261_D0.8500.51
48_I52_Q0.8420.51
199_D219_Q0.8410.51
229_R236_Y0.8280.50
24_A29_V0.8240.49
140_P185_G0.8230.49
81_C157_D0.8210.49
238_A286_V0.8200.49
73_Q83_T0.8190.49
158_E225_N0.8150.48
105_L112_V0.8140.48
197_T244_A0.8110.48
169_S196_G0.8100.48
211_L217_Y0.8100.48
120_A161_E0.8040.48
34_A44_R0.8020.47
164_L293_L0.8010.47
209_D220_A0.8000.47
9_F59_A0.7990.47
200_G233_Q0.7990.47
228_G258_Q0.7990.47
23_G76_S0.7970.47
205_V217_Y0.7930.47
240_A243_K0.7920.47
203_D221_K0.7910.46
261_D265_S0.7880.46
42_S146_Q0.7820.46
61_W65_R0.7810.46
162_N302_Y0.7780.45
251_T274_G0.7770.45
217_Y244_A0.7760.45
5_T9_F0.7730.45
194_V223_W0.7730.45
140_P151_L0.7690.45
161_E167_S0.7680.44
28_D137_K0.7680.44
88_D159_V0.7670.44
148_L263_A0.7630.44
97_M249_F0.7620.44
16_Y29_V0.7610.44
102_T106_A0.7600.44
131_D149_K0.7590.44
246_R287_G0.7570.44
128_D132_H0.7550.43
160_L278_V0.7480.43
144_L148_L0.7400.42
197_T224_Q0.7400.42
225_N254_G0.7390.42
166_V174_I0.7370.42
136_A298_L0.7350.42
212_G281_M0.7340.42
245_K267_E0.7330.42
200_G241_G0.7330.42
75_L294_K0.7310.41
240_A244_A0.7300.41
81_C117_R0.7290.41
184_Y209_D0.7250.41
185_G212_G0.7230.41
240_A269_M0.7220.41
179_L243_K0.7200.40
32_A35_D0.7190.40
26_A60_G0.7160.40
136_A261_D0.7160.40
184_Y211_L0.7160.40
102_T112_V0.7120.40
180_H190_D0.7060.39
118_P260_R0.7050.39
159_V298_L0.7050.39
51_G147_A0.7010.39
15_R83_T0.7010.39
116_S120_A0.6980.39
228_G262_F0.6930.38
214_E272_V0.6920.38
33_A43_Q0.6900.38
138_S146_Q0.6870.38
5_T72_S0.6860.38
138_S143_R0.6840.38
9_F37_L0.6790.37
168_P200_G0.6780.37
206_I217_Y0.6770.37
172_E251_T0.6750.37
48_I51_G0.6750.37
179_L248_V0.6730.37
206_I220_A0.6730.37
182_L212_G0.6720.37
207_S283_E0.6680.36
86_G280_L0.6680.36
71_L101_E0.6680.36
61_W246_R0.6670.36
217_Y281_M0.6640.36
159_V282_I0.6630.36
212_G270_V0.6600.36
57_N60_G0.6590.36
241_G266_V0.6580.35
66_L70_G0.6580.35
181_R294_K0.6530.35
105_L109_F0.6530.35
294_K302_Y0.6510.35
26_A33_A0.6490.35
132_H260_R0.6450.34
73_Q76_S0.6430.34
262_F270_V0.6410.34
164_L225_N0.6400.34
131_D153_D0.6380.34
64_D112_V0.6370.34
51_G86_G0.6370.34
215_K242_Q0.6370.34
185_G213_L0.6360.34
232_L263_A0.6350.34
91_A132_H0.6350.34
48_I54_V0.6330.34
103_N106_A0.6330.34
233_Q237_G0.6320.33
4_P9_F0.6320.33
243_K268_G0.6310.33
27_R30_H0.6300.33
240_A267_E0.6290.33
275_E279_H0.6270.33
108_A112_V0.6260.33
19_T82_L0.6240.33
28_D132_H0.6230.33
155_V212_G0.6220.33
261_D269_M0.6210.33
260_R263_A0.6210.33
264_Q267_E0.6200.33
233_Q256_T0.6190.32
149_K153_D0.6180.32
86_G211_L0.6180.32
169_S173_V0.6150.32
178_V252_T0.6130.32
236_Y243_K0.6130.32
196_G202_I0.6090.32
170_R270_V0.6090.32
235_F249_F0.6090.32
280_L284_N0.6080.32
110_V114_L0.6080.32
63_H74_S0.6070.32
75_L78_G0.6050.31
102_T105_L0.6050.31
287_G303_F0.6040.31
20_K24_A0.6030.31
73_Q84_P0.6020.31
180_H239_L0.6010.31
110_V260_R0.6010.31
172_E194_V0.5990.31
36_A135_L0.5980.31
185_G206_I0.5980.31
206_I238_A0.5960.31
45_A134_E0.5940.31
263_A280_L0.5910.30
70_G202_I0.5900.30
190_D193_R0.5900.30
152_R250_I0.5890.30
250_I286_V0.5870.30
238_A241_G0.5870.30
81_C218_V0.5850.30
230_P301_D0.5850.30
171_F202_I0.5830.30
180_H195_G0.5830.30
75_L80_W0.5830.30
99_E109_F0.5800.30
209_D217_Y0.5800.30
99_E103_N0.5800.30
184_Y218_V0.5800.30
143_R150_E0.5790.30
137_K275_E0.5790.30
121_V161_E0.5790.30
214_E278_V0.5780.29
245_K295_V0.5750.29
208_L213_L0.5740.29
50_S77_R0.5740.29
202_I225_N0.5730.29
298_L303_F0.5730.29
182_L220_A0.5710.29
287_G299_D0.5710.29
34_A39_L0.5700.29
12_P62_A0.5690.29
103_N110_V0.5680.29
190_D240_A0.5670.29
37_L43_Q0.5650.29
270_V281_M0.5640.29
212_G216_V0.5630.28
54_V270_V0.5620.28
170_R174_I0.5610.28
103_N131_D0.5610.28
61_W64_D0.5590.28
216_V249_F0.5590.28
277_L280_L0.5570.28
203_D219_Q0.5550.28
84_P181_R0.5550.28
136_A150_E0.5540.28
175_V184_Y0.5540.28
27_R56_K0.5540.28
61_W204_G0.5530.28
177_D181_R0.5530.28
173_V180_H0.5530.28
14_L66_L0.5530.28
238_A250_I0.5510.28
128_D131_D0.5490.27
241_G265_S0.5490.27
182_L208_L0.5480.27
10_I13_V0.5480.27
5_T11_E0.5470.27
272_V284_N0.5470.27
210_K280_L0.5470.27
31_E35_D0.5460.27
46_K72_S0.5420.27
248_V282_I0.5420.27
119_D128_D0.5380.27
296_P300_M0.5380.27
221_K237_G0.5380.27
176_L194_V0.5370.27
231_E238_A0.5370.27
116_S133_E0.5370.27
200_G248_V0.5370.27
24_A28_D0.5360.27
97_M101_E0.5360.27
13_V60_G0.5350.27
53_L150_E0.5350.27
220_A252_T0.5340.26
176_L248_V0.5330.26
219_Q237_G0.5330.26
120_A134_E0.5320.26
185_G220_A0.5290.26
216_V235_F0.5290.26
128_D134_E0.5280.26
132_H138_S0.5280.26
60_G64_D0.5280.26
26_A63_H0.5260.26
273_D282_I0.5250.26
92_S232_L0.5240.26
58_R212_G0.5230.26
84_P128_D0.5220.26
136_A165_Q0.5210.26
164_L223_W0.5210.26
67_K302_Y0.5180.25
281_M303_F0.5180.25
272_V297_K0.5160.25
38_G283_E0.5160.25
173_V193_R0.5150.25
200_G262_F0.5140.25
215_K267_E0.5140.25
6_Y55_Y0.5140.25
209_D249_F0.5140.25
110_V121_V0.5130.25
35_D129_S0.5130.25
6_Y10_I0.5120.25
81_C87_F0.5100.25
111_N114_L0.5100.25
211_L216_V0.5100.25
129_S136_A0.5100.25
168_P222_R0.5090.25
72_S84_P0.5090.25
228_G256_T0.5080.25
6_Y9_F0.5080.25
50_S62_A0.5080.25
14_L264_Q0.5070.25
96_P232_L0.5070.25
243_K265_S0.5060.25
161_E196_G0.5050.25
13_V30_H0.5050.25
133_E137_K0.5040.25
192_Q226_T0.5040.25
226_T234_A0.5030.24
120_A298_L0.5010.24
208_L211_L0.5000.24
193_R266_V0.5000.24
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4oc8A 4 0.8553 100 0.593 Contact Map
4f0qA 4 0.8882 100 0.63 Contact Map
1y88A 5 0.4309 99.9 0.725 Contact Map
1xmkA 1 0.2401 91.8 0.942 Contact Map
2lnbA 1 0.227 91.1 0.943 Contact Map
1ghcA 1 0.2303 87.2 0.947 Contact Map
1ob8A 1 0.3882 86 0.948 Contact Map
2eo0A 2 0.375 84.7 0.949 Contact Map
2lsoA 1 0.2533 84.2 0.949 Contact Map
1gefA 2 0.3684 83.2 0.95 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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