GREMLIN Database
HYPE - Hydrogenase isoenzymes formation protein HypE
UniProt: P24193 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10487
Length: 336 (289)
Sequences: 14659 (9204)
Seq/√Len: 541.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
169_V302_L3.3451.00
243_E307_V3.0901.00
243_E305_E3.0801.00
283_A286_Q2.7391.00
279_V287_V2.7261.00
166_A308_E2.6021.00
168_D217_K2.5631.00
245_S248_A2.5311.00
215_G283_A2.4621.00
169_V284_A2.4111.00
169_V305_E2.3441.00
70_G111_A2.3381.00
235_A242_I2.3231.00
217_K280_E2.3231.00
170_L278_A2.3101.00
70_G118_E2.3081.00
240_C306_V2.2991.00
171_L302_L2.2881.00
111_A114_T2.2521.00
171_L288_L2.2331.00
54_A89_A2.2081.00
117_A121_R2.1281.00
280_E283_A2.0991.00
231_V242_I2.0821.00
284_A302_L2.0711.00
288_L300_A2.0591.00
284_A288_L2.0051.00
171_L300_A1.9721.00
241_G307_V1.9681.00
42_D155_A1.9601.00
70_G114_T1.9071.00
69_G143_L1.8791.00
169_V281_R1.8631.00
231_V244_L1.8591.00
281_R305_E1.8371.00
80_T149_G1.8361.00
241_G309_R1.8241.00
171_L279_V1.7991.00
166_A240_C1.7951.00
213_I290_A1.7641.00
92_R152_A1.7451.00
243_E313_R1.7391.00
50_G155_A1.7301.00
74_K119_T1.7241.00
170_L242_I1.7221.00
84_V89_A1.6941.00
56_S149_G1.6881.00
40_R54_A1.6691.00
171_L284_A1.6691.00
234_F278_A1.6641.00
217_K278_A1.6621.00
285_E289_A1.6331.00
178_D186_L1.6011.00
118_E121_R1.5751.00
165_T280_E1.5741.00
286_Q289_A1.5641.00
302_L305_E1.5421.00
164_L306_V1.5151.00
118_E122_A1.5111.00
164_L218_A1.5091.00
52_R155_A1.5021.00
51_D154_P1.4651.00
242_I306_V1.4551.00
51_D152_A1.4521.00
168_D280_E1.4501.00
219_L277_I1.4481.00
291_L300_A1.4441.00
114_T118_E1.4391.00
55_F95_S1.4031.00
38_Q87_S1.3991.00
98_F109_L1.3891.00
218_A234_F1.3811.00
178_D252_K1.3661.00
285_E288_L1.3651.00
59_S146_N1.3641.00
84_V149_G1.3601.00
96_C116_M1.3541.00
90_I208_Q1.3531.00
164_L278_A1.3501.00
159_W219_L1.3461.00
31_W52_R1.3431.00
279_V284_A1.3401.00
71_N74_K1.3371.00
165_T217_K1.3341.00
231_V276_V1.3341.00
95_S129_T1.3331.00
210_L287_V1.3161.00
278_A306_V1.3061.00
288_L302_L1.2951.00
71_N115_S1.2921.00
241_G310_K1.2921.00
99_I135_V1.2761.00
168_D306_V1.2601.00
55_F150_M1.2541.00
50_G156_N1.2471.00
119_T122_A1.2471.00
219_L275_L1.2471.00
180_G183_I1.2461.00
153_I158_H1.2401.00
252_K255_V1.2281.00
76_A145_I1.2251.00
222_A230_V1.2241.00
209_T212_D1.2191.00
213_I286_Q1.2161.00
288_L292_H1.2141.00
196_L200_C1.2041.00
39_A128_V1.2021.00
197_V200_C1.2001.00
245_S305_E1.1981.00
171_L287_V1.1931.00
57_T97_G1.1891.00
190_L193_D1.1881.00
206_L291_L1.1861.00
86_V219_L1.1851.00
289_A293_S1.1761.00
93_Y128_V1.1671.00
222_A276_V1.1601.00
57_T148_A1.1591.00
38_Q54_A1.1551.00
286_Q290_A1.1541.00
77_I116_M1.1531.00
208_Q212_D1.1461.00
169_V279_V1.1371.00
206_L209_T1.1251.00
120_A127_I1.1221.00
175_T178_D1.1181.00
160_G163_T1.1131.00
69_G108_T1.1101.00
77_I94_L1.1021.00
170_L276_V1.1011.00
74_K122_A1.0951.00
81_A149_G1.0891.00
154_P157_I1.0871.00
48_A51_D1.0831.00
100_L109_L1.0801.00
157_I212_D1.0791.00
19_I25_E1.0791.00
218_A278_A1.0771.00
290_A293_S1.0691.00
94_L149_G1.0681.00
19_I22_L1.0671.00
52_R153_I1.0601.00
95_S148_A1.0551.00
78_C119_T1.0521.00
209_T213_I1.0461.00
135_V144_F1.0451.00
107_E111_A1.0441.00
52_R158_H1.0381.00
164_L234_F1.0331.00
68_P71_N1.0331.00
178_D183_I1.0321.00
290_A296_L1.0311.00
105_P108_T1.0281.00
214_P287_V1.0211.00
287_V290_A1.0201.00
54_A84_V1.0121.00
168_D278_A1.0101.00
293_S296_L1.0071.00
43_L152_A1.0031.00
251_V256_R0.9991.00
188_E192_L0.9971.00
55_F148_A0.9891.00
74_K118_E0.9821.00
289_A292_H0.9741.00
27_F90_I0.9711.00
163_T217_K0.9701.00
190_L198_S0.9691.00
227_V276_V0.9611.00
220_R233_E0.9591.00
180_G269_F0.9521.00
214_P290_A0.9481.00
81_A125_I0.9431.00
77_I120_A0.9381.00
277_I287_V0.9371.00
204_T208_Q0.9301.00
196_L199_D0.9281.00
36_E87_S0.9271.00
220_R276_V0.9261.00
182_T185_N0.9221.00
48_A152_A0.9191.00
231_V235_A0.9151.00
287_V291_L0.9141.00
42_D50_G0.9131.00
157_I214_P0.9121.00
17_Q21_S0.9111.00
199_D202_V0.9031.00
123_A202_V0.9021.00
19_I23_F0.9011.00
71_N201_A0.8991.00
188_E193_D0.8981.00
178_D181_A0.8961.00
42_D48_A0.8941.00
73_G112_V0.8921.00
90_I212_D0.8861.00
207_I275_L0.8851.00
56_S84_V0.8811.00
75_L272_E0.8801.00
73_G115_S0.8791.00
116_M147_T0.8761.00
207_I211_R0.8751.00
40_R158_H0.8751.00
93_Y150_M0.8721.00
167_G305_E0.8701.00
243_E246_E0.8651.00
189_Q192_L0.8621.00
267_L272_E0.8541.00
106_M110_K0.8491.00
173_S277_I0.8481.00
93_Y126_A0.8471.00
22_L25_E0.8461.00
77_I81_A0.8461.00
74_K78_C0.8451.00
271_N274_K0.8441.00
173_S291_L0.8421.00
68_P194_G0.8401.00
20_N24_M0.8371.00
164_L238_C0.8291.00
100_L112_V0.8291.00
202_V206_L0.8251.00
160_G164_L0.8251.00
256_R260_E0.8241.00
59_S97_G0.8221.00
109_L134_V0.8201.00
183_I187_R0.8181.00
255_V259_C0.8181.00
42_D52_R0.8111.00
209_T296_L0.8081.00
97_G146_N0.8071.00
21_S110_K0.8051.00
37_D220_R0.8041.00
241_G311_G0.8021.00
101_E104_L0.8011.00
120_A125_I0.8011.00
31_W42_D0.8011.00
32_L160_G0.8011.00
94_L120_A0.7901.00
235_A306_V0.7881.00
29_N41_L0.7841.00
81_A119_T0.7821.00
94_L147_T0.7811.00
166_A307_V0.7801.00
76_A147_T0.7791.00
135_V138_G0.7781.00
215_G286_Q0.7771.00
40_R87_S0.7751.00
63_D142_K0.7721.00
214_P283_A0.7721.00
222_A274_K0.7711.00
102_E105_P0.7701.00
80_T147_T0.7691.00
227_V231_V0.7671.00
30_P33_A0.7671.00
166_A169_V0.7661.00
170_L306_V0.7651.00
77_I119_T0.7651.00
90_I124_G0.7641.00
94_L116_M0.7561.00
230_V276_V0.7541.00
188_E191_G0.7541.00
161_A164_L0.7541.00
112_V116_M0.7521.00
257_G261_L0.7511.00
285_E302_L0.7501.00
189_Q193_D0.7491.00
36_E161_A0.7421.00
173_S275_L0.7411.00
179_H271_N0.7401.00
30_P126_A0.7381.00
65_L142_K0.7361.00
85_A208_Q0.7361.00
170_L174_G0.7281.00
209_T290_A0.7211.00
98_F145_I0.7201.00
59_S99_I0.7201.00
202_V205_P0.7191.00
235_A312_V0.7181.00
281_R284_A0.7161.00
86_V275_L0.7121.00
180_G184_L0.7071.00
171_L277_I0.7011.00
70_G115_S0.7011.00
101_E105_P0.7001.00
179_H182_T0.6931.00
292_H299_D0.6911.00
210_L291_L0.6911.00
254_A257_G0.6901.00
60_Y76_A0.6881.00
266_A270_A0.6881.00
90_I205_P0.6841.00
206_L296_L0.6821.00
56_S80_T0.6811.00
108_T112_V0.6811.00
259_C263_G0.6811.00
64_P75_L0.6801.00
52_R156_N0.6801.00
89_A153_I0.6751.00
112_V145_I0.6751.00
250_P301_A0.6701.00
21_S106_M0.6701.00
41_L93_Y0.6681.00
204_T207_I0.6671.00
25_E121_R0.6671.00
73_G116_M0.6671.00
60_Y79_G0.6661.00
159_W211_R0.6651.00
228_N268_N0.6651.00
307_V313_R0.6591.00
207_I219_L0.6581.00
235_A238_C0.6581.00
90_I152_A0.6571.00
239_G309_R0.6571.00
205_P274_K0.6551.00
29_N42_D0.6541.00
40_R52_R0.6521.00
165_T168_D0.6521.00
159_W216_V0.6521.00
201_A298_K0.6501.00
181_A255_V0.6491.00
195_E199_D0.6491.00
21_S25_E0.6441.00
222_A227_V0.6431.00
207_I277_I0.6411.00
110_K114_T0.6381.00
182_T187_R0.6371.00
257_G260_E0.6371.00
108_T111_A0.6351.00
54_A153_I0.6331.00
229_A268_N0.6311.00
199_D203_L0.6291.00
229_A233_E0.6291.00
252_K259_C0.6281.00
116_M145_I0.6251.00
74_K200_C0.6251.00
183_I186_L0.6251.00
25_E110_K0.6231.00
99_I133_K0.6201.00
181_A185_N0.6201.00
27_F126_A0.6161.00
209_T293_S0.6141.00
94_L127_I0.6101.00
253_P256_R0.6031.00
180_G265_D0.6021.00
221_D233_E0.6011.00
205_P208_Q0.6011.00
228_N267_L0.6001.00
182_T186_L0.6001.00
57_T95_S0.6001.00
309_R313_R0.6001.00
172_V176_L0.5981.00
177_G181_A0.5971.00
184_L187_R0.5971.00
27_F30_P0.5971.00
37_D221_D0.5971.00
68_P111_A0.5971.00
83_D221_D0.5951.00
190_L195_E0.5951.00
252_K257_G0.5951.00
58_D83_D0.5941.00
253_P257_G0.5941.00
72_I112_V0.5941.00
248_A301_A0.5931.00
198_S202_V0.5921.00
207_I210_L0.5901.00
81_A123_A0.5881.00
18_L22_L0.5871.00
255_V258_V0.5871.00
57_T146_N0.5850.99
200_C204_T0.5820.99
211_R219_L0.5800.99
250_P253_P0.5780.99
48_A154_P0.5770.99
24_M35_Q0.5760.99
200_C203_L0.5760.99
246_E314_L0.5760.99
55_F93_Y0.5750.99
100_L108_T0.5720.99
99_I144_F0.5700.99
123_A204_T0.5680.99
122_A205_P0.5670.99
214_P286_Q0.5660.99
96_C113_V0.5660.99
154_P212_D0.5660.99
164_L217_K0.5620.99
170_L244_L0.5610.99
115_S119_T0.5590.99
30_P128_V0.5590.99
62_I66_F0.5570.99
136_Q142_K0.5560.99
195_E198_S0.5550.99
28_A33_A0.5540.99
215_G290_A0.5520.99
215_G280_E0.5520.99
41_L128_V0.5500.99
285_E292_H0.5480.99
256_R259_C0.5480.99
174_G301_A0.5480.99
159_W163_T0.5480.99
229_A232_H0.5460.99
232_H236_A0.5430.99
205_P209_T0.5400.99
203_L275_L0.5380.99
108_T141_D0.5350.99
180_G185_N0.5350.99
95_S128_V0.5330.99
43_L48_A0.5310.99
119_T202_V0.5290.99
104_L108_T0.5280.99
201_A205_P0.5270.99
206_L298_K0.5250.99
174_G299_D0.5220.99
307_V310_K0.5220.99
251_V266_A0.5190.99
164_L240_C0.5190.99
62_I67_F0.5180.99
210_L216_V0.5170.99
85_A204_T0.5160.99
49_E154_P0.5140.99
18_L23_F0.5140.99
287_V300_A0.5140.99
251_V259_C0.5130.99
308_E311_G0.5120.99
246_E267_L0.5120.99
296_L299_D0.5100.99
19_I24_M0.5070.99
20_N25_E0.5070.99
232_H312_V0.5060.99
59_S62_I0.5050.99
168_D281_R0.5050.99
102_E134_V0.5030.98
208_Q211_R0.5020.98
78_C200_C0.5020.98
27_F41_L0.5020.98
203_L207_I0.5010.98
21_S24_M0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2z1uA 2 0.9643 100 0.176 Contact Map
3wjpA 2 0.9673 100 0.195 Contact Map
3vtiC 2 0.9048 100 0.207 Contact Map
2rb9A 2 0.9524 100 0.213 Contact Map
2zodA 2 0.8631 100 0.28 Contact Map
3fd5A 2 0.9286 100 0.28 Contact Map
3viuA 1 0.8958 100 0.287 Contact Map
1vk3A 1 0.875 100 0.294 Contact Map
3u0oA 2 0.878 100 0.303 Contact Map
3mcqA 2 0.869 100 0.313 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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