GREMLIN Database
HYPD - Hydrogenase isoenzymes formation protein HypD
UniProt: P24192 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10486
Length: 373 (356)
Sequences: 1163 (721)
Seq/√Len: 38.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
133_Q164_R6.3621.00
139_K170_Y4.3021.00
225_A235_G4.1641.00
139_K307_H3.9741.00
183_R217_D3.8941.00
159_Q272_D3.8501.00
157_T169_F3.2301.00
326_V331_C3.1921.00
158_L295_L3.1461.00
62_E332_K3.1071.00
177_T180_P3.0941.00
203_S211_Y2.9401.00
212_N260_D2.8951.00
92_I135_N2.8871.00
130_K134_E2.8871.00
275_C296_T2.8471.00
36_R62_E2.8411.00
215_A250_V2.8271.00
272_D298_D2.7451.00
170_Y307_H2.7371.00
322_R331_C2.6811.00
112_A117_A2.6011.00
212_N216_S2.5551.00
171_F295_L2.5251.00
238_M251_E2.4671.00
80_D105_K2.4391.00
300_Q306_A2.4291.00
279_D287_V2.4221.00
213_F217_D2.3201.00
322_R325_E2.2921.00
37_I239_L2.2590.99
204_M257_V2.2040.99
23_R241_Q2.2020.99
231_D256_R2.1590.99
40_V178_L2.1300.99
264_L267_Q2.1300.99
275_C294_H2.1190.99
128_A169_F2.1040.99
242_Q251_E2.0650.99
206_I210_A2.0590.99
37_I195_A2.0300.99
162_K301_R1.9820.99
90_E138_R1.9750.99
198_A222_L1.9630.99
183_R213_F1.9620.99
23_R240_V1.8680.98
118_D138_R1.8600.98
48_I232_L1.8560.98
39_E45_T1.8460.98
167_Q301_R1.8240.98
94_C131_L1.8200.98
195_A239_L1.7910.97
278_G294_H1.7810.97
123_Y127_D1.7490.97
80_D104_G1.7360.97
297_P300_Q1.7310.97
160_Q164_R1.7180.97
37_I243_K1.7110.96
158_L162_K1.7070.96
151_M270_I1.7040.96
85_I141_V1.7010.96
196_F220_R1.6810.96
209_D212_N1.6790.96
154_T175_H1.6770.96
238_M253_Q1.6700.96
92_I138_R1.6370.95
81_T305_E1.6150.95
24_A60_N1.6070.95
133_Q166_V1.6020.95
338_L349_F1.5860.95
261_A264_L1.5780.94
183_R187_E1.5750.94
130_K133_Q1.5710.94
275_C297_P1.5670.94
234_Q253_Q1.5660.94
268_Q272_D1.5460.94
125_P157_T1.5360.94
208_T224_V1.5300.93
223_V238_M1.5270.93
23_R237_V1.4910.92
187_E218_F1.4590.92
96_F125_P1.4530.91
151_M293_V1.4500.91
160_Q163_A1.4490.91
162_K302_F1.4390.91
65_H176_I1.4280.91
208_T260_D1.4160.90
131_L135_N1.4120.90
323_C352_L1.4100.90
162_K298_D1.4050.90
43_G65_H1.4030.90
122_V142_F1.3980.90
279_D289_E1.3810.89
82_C172_F1.3780.89
159_Q273_V1.3640.89
107_G112_A1.3630.89
84_E88_H1.3440.88
209_D261_A1.3410.88
87_S112_A1.3370.88
93_F143_F1.3340.87
245_A249_K1.3330.87
170_Y308_F1.3320.87
63_F236_V1.3080.86
188_Q328_T1.3060.86
203_S206_I1.2960.86
265_L268_Q1.2830.85
129_L157_T1.2680.85
222_L250_V1.2450.84
73_V176_I1.2390.83
46_H65_H1.2360.83
294_H303_D1.2280.83
161_A169_F1.2200.82
326_V335_Q1.2170.82
223_V251_E1.2010.81
44_H199_P1.2000.81
234_Q238_M1.1980.81
35_L243_K1.1900.81
92_I118_D1.1870.80
322_R337_P1.1800.80
159_Q299_Y1.1780.80
33_R194_D1.1760.80
44_H323_C1.1700.80
279_D290_S1.1690.79
90_E139_K1.1670.79
23_R244_I1.1630.79
177_T276_V1.1600.79
37_I236_V1.1560.79
92_I131_L1.1520.78
158_L273_V1.1480.78
181_T288_I1.1470.78
320_R338_L1.1420.78
96_F153_T1.1400.78
237_V241_Q1.1350.77
334_H363_W1.1310.77
322_R326_V1.1250.77
61_V240_V1.1250.77
331_C335_Q1.1150.76
208_T212_N1.1140.76
264_L268_Q1.1030.75
300_Q303_D1.0960.75
282_W291_S1.0790.74
107_G115_R1.0760.73
242_Q249_K1.0750.73
182_L196_F1.0720.73
321_A352_L1.0680.73
209_D267_Q1.0670.73
82_C143_F1.0660.73
35_L240_V1.0610.72
9_A12_Q1.0570.72
297_P306_A1.0540.72
228_E256_R1.0480.71
178_L211_Y1.0470.71
177_T181_T1.0390.71
272_D299_Y1.0360.71
34_P62_E1.0330.70
199_P352_L1.0320.70
223_V253_Q1.0320.70
44_H352_L1.0280.70
158_L302_F1.0250.70
86_A117_A1.0240.70
43_G176_I1.0220.70
65_H359_A1.0160.69
228_E231_D1.0080.68
46_H362_A1.0070.68
19_H241_Q1.0070.68
241_Q245_A1.0010.68
135_N140_V0.9980.68
209_D260_D0.9980.68
162_K272_D0.9900.67
162_K273_V0.9890.67
78_R174_Q0.9880.67
96_F154_T0.9870.67
45_T166_V0.9820.66
84_E311_A0.9780.66
205_V296_T0.9770.66
83_V107_G0.9720.66
96_F123_Y0.9710.66
51_F232_L0.9690.65
61_V299_Y0.9680.65
128_A157_T0.9630.65
46_H198_A0.9630.65
17_I21_R0.9630.65
193_I220_R0.9610.65
43_G101_R0.9520.64
184_S288_I0.9510.64
40_V196_F0.9470.64
77_G281_E0.9390.63
180_P276_V0.9360.63
174_Q280_S0.9250.62
92_I120_R0.9160.61
37_I63_F0.9150.61
10_P14_M0.9130.61
221_P248_S0.9130.61
95_T100_M0.9090.60
199_P323_C0.9050.60
63_F200_G0.9020.60
78_R172_F0.8980.59
280_S292_G0.8970.59
190_D330_K0.8970.59
48_I63_F0.8960.59
17_I233_L0.8940.59
158_L171_F0.8880.59
93_F141_V0.8880.59
43_G46_H0.8840.58
186_L214_I0.8800.58
31_A35_L0.8780.58
81_T172_F0.8780.58
16_L237_V0.8740.57
120_R131_L0.8720.57
78_R143_F0.8620.56
57_L63_F0.8560.56
120_R138_R0.8550.56
200_G254_Y0.8550.56
44_H239_L0.8530.55
61_V289_E0.8520.55
94_C122_V0.8510.55
129_L166_V0.8470.55
181_T293_V0.8460.55
65_H222_L0.8420.54
19_H22_E0.8400.54
278_G290_S0.8340.54
190_D194_D0.8330.54
188_Q330_K0.8320.54
215_A248_S0.8280.53
39_E166_V0.8260.53
259_P264_L0.8240.53
85_I101_R0.8210.53
187_E217_D0.8210.53
40_V125_P0.8200.53
54_D65_H0.8180.52
49_F363_W0.8130.52
200_G326_V0.8120.52
229_P256_R0.8110.52
65_H198_A0.8090.52
87_S115_R0.8070.51
45_T161_A0.8040.51
14_M21_R0.8030.51
276_V296_T0.7980.51
75_P78_R0.7970.50
22_E217_D0.7960.50
83_V112_A0.7950.50
177_T293_V0.7910.50
247_H251_E0.7900.50
39_E65_H0.7860.49
80_D196_F0.7860.49
214_I222_L0.7840.49
205_V266_A0.7820.49
238_M242_Q0.7810.49
18_E241_Q0.7810.49
10_P17_I0.7790.49
265_L269_A0.7750.49
37_I224_V0.7740.48
92_I140_V0.7740.48
45_T362_A0.7730.48
203_S323_C0.7700.48
87_S107_G0.7690.48
46_H176_I0.7690.48
45_T65_H0.7680.48
87_S197_L0.7680.48
294_H306_A0.7650.48
144_G295_L0.7630.47
235_G239_L0.7610.47
177_T291_S0.7610.47
208_T252_N0.7600.47
12_Q15_Q0.7600.47
78_R82_C0.7570.47
11_E14_M0.7560.47
200_G232_L0.7520.46
110_L113_K0.7510.46
182_L186_L0.7510.46
35_L244_I0.7500.46
183_R218_F0.7490.46
325_E328_T0.7480.46
44_H203_S0.7480.46
93_F308_F0.7470.46
196_F288_I0.7460.46
43_G198_A0.7460.46
39_E362_A0.7420.46
91_V141_V0.7400.45
320_R337_P0.7380.45
14_M306_A0.7370.45
97_G200_G0.7330.45
77_G315_V0.7330.45
94_C169_F0.7320.45
84_E309_R0.7320.45
14_M18_E0.7260.44
47_A51_F0.7260.44
13_V53_L0.7250.44
182_L213_F0.7250.44
11_E22_E0.7220.44
104_G292_G0.7210.44
153_T179_I0.7210.44
361_A365_Q0.7190.44
140_V161_A0.7190.44
47_A232_L0.7180.43
19_H237_V0.7160.43
162_K299_Y0.7140.43
171_F307_H0.7130.43
103_P348_A0.7130.43
268_Q271_A0.7120.43
241_Q251_E0.7120.43
94_C117_A0.7080.43
36_R99_A0.7050.42
86_A112_A0.7040.42
33_R243_K0.7040.42
39_E286_G0.7030.42
57_L324_G0.7020.42
199_P203_S0.7010.42
126_M224_V0.7000.42
163_A326_V0.6980.42
303_D306_A0.6970.42
126_M157_T0.6940.41
18_E272_D0.6920.41
144_G351_A0.6920.41
192_G289_E0.6900.41
138_R306_A0.6900.41
185_L292_G0.6890.41
99_A104_G0.6890.41
159_Q163_A0.6890.41
44_H108_S0.6860.41
165_D264_L0.6860.41
326_V366_Y0.6830.40
235_G278_G0.6810.40
342_T347_T0.6800.40
145_L311_A0.6800.40
153_T156_I0.6780.40
39_E161_A0.6750.40
35_L44_H0.6740.40
7_Y157_T0.6730.40
337_P351_A0.6710.39
43_G78_R0.6700.39
176_I222_L0.6690.39
195_A341_N0.6660.39
356_S362_A0.6650.39
14_M209_D0.6640.39
36_R239_L0.6630.39
176_I280_S0.6630.39
139_K308_F0.6610.38
261_A271_A0.6590.38
214_I218_F0.6590.38
294_H305_E0.6570.38
92_I141_V0.6560.38
348_A363_W0.6560.38
235_G253_Q0.6550.38
197_L279_D0.6540.38
175_H178_L0.6540.38
219_H246_A0.6520.38
127_D130_K0.6510.38
96_F178_L0.6510.38
195_A346_Q0.6480.37
166_V302_F0.6470.37
161_A166_V0.6470.37
96_F200_G0.6470.37
108_S323_C0.6460.37
182_L185_L0.6460.37
35_L323_C0.6440.37
185_L196_F0.6410.37
63_F195_A0.6380.37
78_R280_S0.6360.36
81_T351_A0.6350.36
9_A184_S0.6340.36
114_A209_D0.6330.36
13_V230_L0.6320.36
158_L265_L0.6320.36
54_D205_V0.6310.36
99_A143_F0.6300.36
143_F198_A0.6290.36
263_N266_A0.6290.36
21_R61_V0.6290.36
278_G292_G0.6280.36
242_Q248_S0.6280.36
43_G74_L0.6280.36
219_H248_S0.6270.36
141_V209_D0.6250.35
108_S239_L0.6240.35
163_A271_A0.6220.35
193_I196_F0.6190.35
10_P16_L0.6190.35
75_P176_I0.6160.35
40_V61_V0.6150.35
155_A274_F0.6150.35
140_V169_F0.6130.35
53_L57_L0.6120.34
55_Q158_L0.6110.34
35_L239_L0.6110.34
46_H222_L0.6110.34
237_V240_V0.6100.34
163_A298_D0.6090.34
339_F366_Y0.6080.34
43_G222_L0.6070.34
163_A297_P0.6060.34
285_L327_L0.6050.34
34_P99_A0.6030.34
45_T176_I0.6030.34
267_Q271_A0.6010.34
181_T184_S0.6000.33
7_Y325_E0.5990.33
304_A308_F0.5980.33
20_L53_L0.5970.33
58_P327_L0.5940.33
131_L140_V0.5940.33
176_I352_L0.5940.33
186_L237_V0.5940.33
210_A213_F0.5910.33
23_R61_V0.5900.33
31_A145_L0.5900.33
175_H253_Q0.5890.33
78_R351_A0.5890.33
50_K197_L0.5880.33
57_L100_M0.5880.33
82_C99_A0.5880.33
31_A34_P0.5870.32
125_P257_V0.5860.32
78_R176_I0.5860.32
206_I224_V0.5850.32
75_P351_A0.5840.32
19_H23_R0.5830.32
273_V296_T0.5810.32
254_Y312_P0.5770.32
90_E144_G0.5750.31
14_M300_Q0.5750.31
82_C144_G0.5740.31
77_G317_D0.5730.31
83_V87_S0.5720.31
64_I154_T0.5720.31
85_I310_P0.5710.31
203_S352_L0.5710.31
18_E218_F0.5700.31
100_M119_V0.5690.31
254_Y315_V0.5680.31
239_L323_C0.5680.31
54_D338_L0.5670.31
44_H280_S0.5670.31
279_D292_G0.5650.31
59_E134_E0.5640.31
156_I159_Q0.5630.31
40_V224_V0.5630.31
65_H280_S0.5620.30
74_L279_D0.5620.30
99_A145_L0.5610.30
39_E176_I0.5600.30
7_Y244_I0.5590.30
96_F121_I0.5590.30
158_L165_D0.5580.30
189_P192_G0.5570.30
123_Y221_P0.5570.30
58_P232_L0.5560.30
306_A326_V0.5550.30
144_G171_F0.5540.30
161_A362_A0.5540.30
199_P286_G0.5520.30
105_K317_D0.5520.30
94_C158_L0.5510.30
144_G176_I0.5510.30
17_I55_Q0.5510.30
199_P327_L0.5500.30
13_V16_L0.5490.30
173_C295_L0.5480.29
123_Y252_N0.5470.29
40_V288_I0.5460.29
59_E216_S0.5460.29
6_E195_A0.5450.29
75_P317_D0.5450.29
176_I362_A0.5450.29
76_M80_D0.5450.29
45_T361_A0.5450.29
272_D290_S0.5440.29
56_L342_T0.5430.29
279_D335_Q0.5420.29
117_A301_R0.5420.29
21_R163_A0.5390.29
203_S210_A0.5390.29
340_G367_R0.5380.29
65_H78_R0.5380.29
45_T125_P0.5380.29
176_I181_T0.5380.29
85_I192_G0.5370.29
218_F270_I0.5370.29
113_K118_D0.5340.28
120_R134_E0.5340.28
76_M326_V0.5330.28
145_L203_S0.5330.28
35_L138_R0.5320.28
43_G359_A0.5310.28
285_L367_R0.5310.28
31_A197_L0.5310.28
161_A302_F0.5290.28
144_G154_T0.5250.28
49_F54_D0.5250.28
174_Q351_A0.5240.28
48_I196_F0.5230.28
18_E22_E0.5230.28
54_D176_I0.5230.28
199_P239_L0.5220.28
199_P206_I0.5210.27
191_N328_T0.5210.27
206_I211_Y0.5200.27
131_L337_P0.5200.27
237_V346_Q0.5200.27
31_A244_I0.5200.27
16_L234_Q0.5190.27
39_E63_F0.5190.27
141_V246_A0.5180.27
8_R228_E0.5180.27
145_L198_A0.5180.27
218_F302_F0.5170.27
152_P161_A0.5170.27
137_T224_V0.5160.27
7_Y10_P0.5150.27
77_G81_T0.5130.27
131_L302_F0.5120.27
326_V339_F0.5120.27
119_V279_D0.5120.27
163_A219_H0.5110.27
55_Q108_S0.5110.27
43_G280_S0.5100.27
248_S364_Y0.5100.27
190_D193_I0.5090.27
74_L176_I0.5090.27
184_S187_E0.5090.27
159_Q323_C0.5060.26
86_A128_A0.5060.26
48_I54_D0.5050.26
21_R59_E0.5050.26
242_Q250_V0.5040.26
79_I279_D0.5040.26
54_D349_F0.5030.26
97_G180_P0.5030.26
94_C140_V0.5030.26
167_Q341_N0.5020.26
212_N261_A0.5020.26
54_D63_F0.5010.26
75_P281_E0.5010.26
39_E361_A0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2z1dA 1 0.9625 100 0.044 Contact Map
1reqA 1 0.5362 91.9 0.968 Contact Map
2xijA 2 0.555 71.1 0.975 Contact Map
4r3uC 1 0.3405 70.4 0.975 Contact Map
2e28A 3 0.5523 70.3 0.975 Contact Map
2q5cA 2 0.4745 70 0.976 Contact Map
1jqkA 3 0.7131 69.9 0.976 Contact Map
3s99A 1 0.8338 58.5 0.977 Contact Map
3t05A 3 0.5469 54.7 0.978 Contact Map
4ht3A 1 0.6247 53.9 0.978 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.011 seconds.