GREMLIN Database
YCEA - UPF0176 protein YceA
UniProt: P24188 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11116
Length: 350 (292)
Sequences: 1589 (896)
Seq/√Len: 52.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
167_E245_I5.5891.00
137_Q225_E5.2081.00
69_I79_F4.3501.00
163_V256_G4.0281.00
186_E216_N3.9171.00
165_H199_Y3.0981.00
49_F109_L3.0441.00
38_P113_V3.0241.00
146_D243_R3.0141.00
139_A234_K2.8471.00
37_D40_A2.7761.00
287_L308_C2.6391.00
31_K92_G2.6361.00
135_Y223_H2.5461.00
53_N75_N2.5301.00
46_Y50_T2.4421.00
25_T73_A2.4241.00
283_D293_P2.2881.00
212_W216_N2.2451.00
229_I248_N2.2001.00
73_A77_E2.1601.00
54_V79_F2.1521.00
73_A97_I2.1211.00
29_F67_A2.1201.00
285_C296_A2.1121.00
47_Q51_A2.0861.00
29_F58_V2.0721.00
195_K220_K2.0571.00
84_Y92_G2.0231.00
303_C307_C2.0231.00
48_L52_L2.0181.00
274_C279_N2.0101.00
299_Y304_S1.9971.00
141_V224_I1.9851.00
77_E81_A1.9841.00
72_P75_N1.9391.00
137_Q140_E1.9381.00
270_C292_C1.9381.00
70_S105_S1.9361.00
230_E234_K1.9351.00
94_R225_E1.9290.99
270_C295_C1.8990.99
54_V69_I1.8860.99
292_C295_C1.8630.99
247_K263_I1.8370.99
186_E212_W1.8230.99
162_E294_V1.8190.99
253_E268_H1.8160.99
25_T77_E1.8140.99
265_A279_N1.8000.99
167_E243_R1.7980.99
80_R95_L1.7280.99
158_H175_D1.7210.99
136_L140_E1.7090.99
46_Y109_L1.7090.99
257_E260_S1.7000.99
311_S315_P1.6560.98
131_N214_K1.6540.98
43_D47_Q1.6540.98
272_A298_K1.5850.98
309_E312_A1.5840.98
143_A147_D1.5750.98
316_E320_R1.5630.98
305_E308_C1.5290.97
151_L196_I1.5100.97
188_M192_K1.4960.97
162_E171_E1.4960.97
54_V109_L1.4940.97
52_L75_N1.4810.97
230_E233_R1.4730.97
267_C270_C1.4670.97
277_H290_I1.4350.96
42_R113_V1.4290.96
315_P319_R1.4100.96
45_L79_F1.3990.96
38_P62_H1.3960.95
155_M181_L1.3950.95
145_L197_V1.3840.95
183_K186_E1.3740.95
267_C295_C1.3620.95
141_V197_V1.3570.95
196_I218_F1.3400.94
311_S314_P1.3380.94
317_E320_R1.3230.94
107_W253_E1.3230.94
314_P318_Q1.3220.94
48_L82_Q1.3090.94
211_A214_K1.3020.93
27_I76_V1.2890.93
267_C292_C1.2830.93
150_A195_K1.2820.93
134_E214_K1.2800.93
26_T100_D1.2740.93
140_E143_A1.2700.93
25_T99_L1.2600.92
37_D89_A1.2560.92
80_R93_L1.2470.92
84_Y93_L1.2440.92
63_E208_K1.2440.92
278_T301_G1.2220.91
272_A294_V1.2210.91
305_E309_E1.2140.91
80_R97_I1.2050.90
161_Y171_E1.2040.90
94_R230_E1.1920.90
278_T293_P1.1720.89
144_M222_W1.1670.89
54_V76_V1.1630.89
187_M190_A1.1520.88
147_D150_A1.1480.88
263_I275_D1.1440.88
84_Y91_E1.1340.88
135_Y225_E1.1260.87
209_A213_M1.1240.87
52_L78_T1.1220.87
145_L152_F1.1210.87
190_A193_D1.1170.87
300_K303_C1.1170.87
285_C293_P1.1150.87
35_I90_L1.1150.87
258_R261_D1.1140.87
120_D177_F1.1120.87
249_F288_L1.1100.86
181_L185_V1.1070.86
269_Q291_Q1.1020.86
188_M191_H1.0990.86
188_M213_M1.0800.85
176_T179_E1.0660.84
136_L144_M1.0610.84
193_D219_N1.0540.83
42_R60_L1.0510.83
257_E261_D1.0440.83
98_A233_R1.0330.82
118_V178_R1.0320.82
35_I41_T1.0310.82
214_K219_N1.0270.82
123_D131_N1.0210.81
299_Y307_C1.0160.81
265_A274_C1.0030.80
182_P185_V1.0000.80
153_I185_V0.9920.79
229_I233_R0.9830.79
185_V218_F0.9820.79
82_Q85_A0.9810.79
247_K275_D0.9750.78
40_A44_A0.9710.78
27_I95_L0.9650.78
124_D215_H0.9640.77
210_S223_H0.9590.77
60_L113_V0.9570.77
279_N282_N0.9510.77
265_A290_I0.9510.77
48_L54_V0.9500.76
73_A99_L0.9440.76
50_T53_N0.9440.76
25_T97_I0.9410.76
247_K262_E0.9390.76
70_S104_K0.9310.75
133_G221_V0.9270.75
122_I125_P0.9260.75
50_T109_L0.9260.75
198_M249_F0.9240.74
84_Y95_L0.9240.74
48_L75_N0.9220.74
117_I121_G0.9210.74
235_A242_V0.9160.74
291_Q296_A0.9030.73
301_G318_Q0.9020.73
237_E258_R0.8950.72
49_F58_V0.8940.72
33_F89_A0.8910.72
188_M193_D0.8900.72
33_F90_L0.8880.71
34_H62_H0.8820.71
238_Q258_R0.8770.70
49_F79_F0.8730.70
285_C297_E0.8700.70
187_M193_D0.8690.70
151_L193_D0.8440.68
157_N205_R0.8380.67
35_I60_L0.8370.67
126_H129_A0.8360.67
128_D132_V0.8350.67
147_D195_K0.8300.66
48_L51_A0.8290.66
132_V223_H0.8280.66
39_K62_H0.8180.65
304_S307_C0.8170.65
63_E117_I0.8160.65
188_M218_F0.8130.65
90_L218_F0.8120.65
131_N215_H0.8120.65
143_A146_D0.8100.64
264_I275_D0.8100.64
68_Q116_R0.8040.64
238_Q262_E0.8020.64
38_P44_A0.8020.64
152_F243_R0.8000.63
87_D90_L0.7990.63
141_V152_F0.7960.63
43_D50_T0.7950.63
153_I188_M0.7910.62
317_E321_R0.7900.62
94_R137_Q0.7890.62
47_Q50_T0.7880.62
120_D125_P0.7870.62
80_R84_Y0.7760.61
144_M195_K0.7760.61
189_Q193_D0.7760.61
155_M213_M0.7750.61
62_H113_V0.7740.61
59_Y68_Q0.7690.60
177_F250_V0.7650.60
121_G178_R0.7620.60
141_V223_H0.7610.59
28_S68_Q0.7580.59
40_A50_T0.7540.59
35_I38_P0.7530.59
114_R178_R0.7500.58
237_E260_S0.7490.58
187_M191_H0.7480.58
155_M209_A0.7470.58
41_T60_L0.7450.58
32_Y141_V0.7420.58
25_T72_P0.7380.57
142_N235_A0.7370.57
33_F87_D0.7360.57
293_P297_E0.7350.57
171_E175_D0.7350.57
268_H288_L0.7320.57
78_T81_A0.7310.56
130_S215_H0.7290.56
299_Y308_C0.7290.56
285_C307_C0.7230.56
46_Y53_N0.7210.55
312_A316_E0.7200.55
288_L315_P0.7200.55
140_E298_K0.7160.55
174_A181_L0.7160.55
117_I250_V0.7150.55
163_V255_M0.7140.55
315_P318_Q0.7060.54
26_T68_Q0.7050.54
269_Q289_F0.7040.54
24_R72_P0.7010.53
276_S279_N0.6960.53
32_Y248_N0.6940.53
54_V71_V0.6930.52
207_E223_H0.6930.52
26_T105_S0.6920.52
144_M197_V0.6920.52
49_F54_V0.6920.52
35_I87_D0.6910.52
53_N104_K0.6820.51
314_P317_E0.6780.51
126_H196_I0.6750.51
319_R322_R0.6730.50
149_D193_D0.6720.50
69_I109_L0.6710.50
47_Q82_Q0.6690.50
75_N78_T0.6680.50
49_F65_I0.6680.50
172_I244_F0.6660.50
50_T75_N0.6660.50
161_Y165_H0.6660.50
23_P47_Q0.6660.50
316_E321_R0.6650.50
276_S293_P0.6650.50
142_N242_V0.6640.49
213_M216_N0.6600.49
318_Q322_R0.6600.49
279_N285_C0.6580.49
237_E245_I0.6570.49
256_G314_P0.6550.48
88_P91_E0.6550.48
102_D261_D0.6520.48
43_D46_Y0.6510.48
125_P128_D0.6500.48
283_D286_H0.6500.48
299_Y303_C0.6470.48
175_D179_E0.6440.47
229_I247_K0.6440.47
256_G262_E0.6430.47
132_V211_A0.6420.47
51_A278_T0.6400.47
225_E256_G0.6390.47
27_I69_I0.6370.47
31_K95_L0.6360.46
42_R46_Y0.6360.46
61_A115_D0.6330.46
133_G214_K0.6320.46
297_E304_S0.6300.46
134_E140_E0.6300.46
181_L184_A0.6300.46
182_P186_E0.6300.46
189_Q192_K0.6290.46
163_V266_H0.6290.46
162_E176_T0.6290.46
115_D219_N0.6260.45
287_L291_Q0.6260.45
271_G321_R0.6250.45
279_N286_H0.6220.45
257_E262_E0.6210.45
301_G308_C0.6200.45
140_E173_P0.6200.45
125_P131_N0.6200.45
234_K237_E0.6200.45
148_P153_I0.6150.44
106_F204_I0.6130.44
29_F79_F0.6110.44
189_Q196_I0.6110.44
119_A256_G0.6110.44
49_F71_V0.6100.44
27_I239_G0.6080.44
75_N79_F0.6070.43
41_T82_Q0.6070.43
37_D87_D0.6070.43
57_R279_N0.6040.43
29_F54_V0.6030.43
39_K43_D0.6030.43
133_G217_G0.6020.43
38_P87_D0.6000.43
191_H212_W0.5990.43
137_Q147_D0.5990.43
61_A117_I0.5990.43
107_W271_G0.5980.43
107_W112_K0.5980.43
48_L79_F0.5970.42
302_C307_C0.5970.42
181_L228_I0.5960.42
190_A218_F0.5930.42
256_G260_S0.5920.42
261_D275_D0.5910.42
45_L54_V0.5900.42
32_Y122_I0.5900.42
136_L235_A0.5890.42
172_I184_A0.5890.42
28_S67_A0.5890.42
269_Q298_K0.5880.42
69_I75_N0.5880.42
28_S96_N0.5880.42
135_Y210_S0.5870.41
27_I168_N0.5860.41
131_N211_A0.5850.41
266_H309_E0.5850.41
266_H288_L0.5850.41
283_D296_A0.5840.41
152_F167_E0.5820.41
96_N230_E0.5810.41
99_L102_D0.5760.40
142_N197_V0.5740.40
142_N146_D0.5720.40
48_L78_T0.5700.40
152_F224_I0.5700.40
289_F292_C0.5690.40
138_A230_E0.5690.40
104_K307_C0.5670.39
217_G221_V0.5670.39
46_Y52_L0.5650.39
34_H123_D0.5620.39
27_I80_R0.5610.39
27_I67_A0.5600.39
120_D155_M0.5580.38
60_L89_A0.5550.38
159_Y177_F0.5510.38
303_C306_I0.5510.38
181_L186_E0.5510.38
290_I308_C0.5500.38
198_M210_S0.5490.38
49_F213_M0.5480.38
215_H219_N0.5480.38
232_A259_I0.5460.37
45_L83_L0.5460.37
33_F60_L0.5460.37
191_H198_M0.5440.37
272_A293_P0.5440.37
153_I172_I0.5440.37
133_G211_A0.5430.37
96_N116_R0.5430.37
68_Q118_V0.5420.37
255_M288_L0.5420.37
42_R50_T0.5420.37
155_M198_M0.5410.37
224_I250_V0.5410.37
104_K294_V0.5400.37
70_S268_H0.5400.37
168_N244_F0.5400.37
163_V275_D0.5390.37
263_I266_H0.5390.37
36_A298_K0.5380.37
169_A176_T0.5380.37
54_V75_N0.5370.36
242_V262_E0.5370.36
274_C293_P0.5350.36
37_D92_G0.5340.36
210_S214_K0.5330.36
126_H130_S0.5310.36
61_A109_L0.5300.36
26_T146_D0.5290.36
38_P89_A0.5280.36
191_H285_C0.5280.36
105_S208_K0.5260.35
32_Y263_I0.5260.35
92_G168_N0.5230.35
53_N92_G0.5230.35
47_Q74_S0.5220.35
91_E102_D0.5210.35
158_H171_E0.5210.35
135_Y141_V0.5210.35
169_A217_G0.5200.35
42_R45_L0.5190.35
146_D167_E0.5190.35
279_N288_L0.5180.35
71_V76_V0.5180.35
185_V213_M0.5170.35
133_G210_S0.5140.34
152_F168_N0.5140.34
163_V174_A0.5140.34
270_C302_C0.5140.34
32_Y229_I0.5130.34
187_M234_K0.5130.34
134_E222_W0.5120.34
149_D195_K0.5100.34
59_Y114_R0.5090.34
35_I134_E0.5080.34
51_A85_A0.5070.34
51_A215_H0.5070.34
142_N243_R0.5070.34
151_L316_E0.5070.34
51_A277_H0.5060.33
53_N173_P0.5050.33
278_T294_V0.5050.33
155_M255_M0.5050.33
125_P215_H0.5040.33
263_I276_S0.5020.33
83_L216_N0.5010.33
67_A118_V0.5000.33
284_G310_E0.5000.33
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4f67A 1 0.7514 100 0.536 Contact Map
1gmxA 1 0.3086 99.7 0.86 Contact Map
2fsxA 1 0.34 99.6 0.865 Contact Map
1veeA 1 0.3486 99.6 0.866 Contact Map
3d1pA 1 0.3171 99.6 0.867 Contact Map
3fojA 1 0.2829 99.6 0.867 Contact Map
1qb0A 1 0.4514 99.6 0.868 Contact Map
1qxnA 2 0.38 99.6 0.869 Contact Map
3g5jA 1 0.2886 99.6 0.869 Contact Map
4wh9A 1 0.4514 99.6 0.87 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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