GREMLIN Database
FOLD - Bifunctional protein FolD
UniProt: P24186 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10328
Length: 288 (278)
Sequences: 4783 (2959)
Seq/√Len: 177.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_K280_V4.1531.00
151_E182_A3.5331.00
84_D113_R3.2251.00
161_N202_N3.1881.00
245_V248_D3.1801.00
93_D282_Y3.1491.00
76_E109_K3.0331.00
195_N198_H2.9231.00
82_L85_T2.6961.00
14_Q152_R2.6911.00
161_N199_H2.6631.00
165_I216_I2.5751.00
7_D10_T2.5481.00
35_G66_R2.4311.00
80_L113_R2.3721.00
210_V215_F2.2631.00
223_E252_R2.1811.00
68_Y82_L2.1501.00
32_R93_D2.1331.00
57_A268_V2.1251.00
74_T79_L2.1191.00
206_L221_I2.1171.00
84_D88_A2.0931.00
214_G245_V2.0651.00
16_R60_E2.0391.00
218_G248_D2.0271.00
158_F183_G1.9691.00
123_F170_I1.9411.00
176_S188_V1.9281.00
27_I33_A1.9271.00
217_P220_W1.9181.00
162_A179_L1.8761.00
5_I246_F1.8731.00
138_L278_A1.8701.00
221_I249_A1.8651.00
226_I254_S1.8621.00
148_T151_E1.8601.00
97_V110_V1.8121.00
35_G64_V1.8021.00
157_T205_L1.7891.00
147_V182_A1.7851.00
200_V206_L1.7691.00
49_I240_V1.7461.00
246_F256_I1.7341.00
43_S48_Q1.7331.00
235_L239_K1.7181.00
158_F192_F1.6991.00
20_A24_Q1.6911.00
197_R201_E1.6861.00
148_T273_E1.6671.00
11_I153_Y1.6461.00
19_V276_L1.6391.00
61_V272_I1.6221.00
199_H202_N1.6131.00
204_D222_K1.5911.00
132_C177_M1.5241.00
244_V249_A1.5221.00
139_R178_E1.5211.00
227_V244_V1.5121.00
217_P245_V1.5081.00
180_L188_V1.5041.00
160_L194_K1.4801.00
40_L48_Q1.4581.00
148_T270_T1.4401.00
206_L216_I1.4331.00
70_L74_T1.4261.00
16_R57_A1.4241.00
148_T152_R1.4231.00
200_V220_W1.4071.00
164_V175_M1.3971.00
156_D160_L1.3821.00
163_V189_T1.3741.00
76_E80_L1.3741.00
277_Q281_E1.3661.00
66_R92_I1.3581.00
18_E152_R1.3561.00
19_V61_V1.3531.00
198_H202_N1.3501.00
76_E106_D1.3481.00
217_P248_D1.3471.00
49_I53_S1.3231.00
247_E250_A1.3101.00
144_R273_E1.3101.00
218_G249_A1.3101.00
70_L82_L1.3091.00
167_A191_R1.3071.00
144_R277_Q1.3061.00
4_K255_Y1.3001.00
64_V92_I1.2821.00
6_I153_Y1.2771.00
218_G252_R1.2721.00
43_S72_E1.2691.00
189_T199_H1.2681.00
75_S78_E1.2651.00
21_Q24_Q1.2641.00
155_I255_Y1.2641.00
11_I152_R1.2591.00
222_K225_A1.2531.00
214_G241_V1.2491.00
25_A29_A1.2461.00
23_V63_F1.2351.00
163_V203_A1.2341.00
189_T193_T1.2311.00
15_V19_V1.2231.00
37_A68_Y1.1941.00
55_R59_E1.1751.00
106_D109_K1.1701.00
99_L111_L1.1681.00
9_K13_Q1.1671.00
189_T196_L1.1621.00
55_R67_S1.1621.00
73_T78_E1.1561.00
163_V199_H1.1361.00
221_I225_A1.1331.00
52_A56_K1.1231.00
40_L69_D1.1231.00
76_E105_I1.1221.00
66_R89_D1.1221.00
128_V132_C1.1201.00
201_E252_R1.1171.00
214_G247_E1.1171.00
64_V91_T1.1101.00
63_F276_L1.1051.00
17_S21_Q1.1051.00
13_Q17_S1.1041.00
197_R220_W1.0941.00
210_V233_N1.0921.00
37_A92_I1.0901.00
17_S20_A1.0841.00
37_A86_L1.0831.00
212_K215_F1.0621.00
145_G266_M1.0270.99
197_R219_D1.0250.99
249_A256_I1.0240.99
160_L205_L1.0210.99
48_Q69_D1.0200.99
10_T14_Q1.0200.99
235_L241_V1.0170.99
213_P235_L1.0130.99
6_I255_Y1.0120.99
6_I11_I1.0070.99
77_A81_E1.0030.99
33_A64_V0.9980.99
39_V86_L0.9920.99
21_Q25_A0.9910.99
43_S69_D0.9900.99
162_A184_C0.9900.99
112_E125_P0.9630.99
185_T193_T0.9630.99
58_C272_I0.9620.99
15_V269_A0.9610.99
58_C63_F0.9550.99
144_R148_T0.9500.99
80_L109_K0.9440.99
57_A272_I0.9430.99
87_N115_H0.9420.99
48_Q52_A0.9380.99
51_V98_Q0.9360.99
146_I230_V0.9360.99
57_A61_V0.9350.99
136_P277_Q0.9290.99
26_R30_G0.9290.99
183_G192_F0.9230.99
59_E64_V0.9210.99
235_L238_G0.9200.99
81_E85_T0.9160.99
173_R180_L0.9130.99
191_R210_V0.9120.99
165_I210_V0.9100.99
150_L153_Y0.9050.99
248_D251_K0.9030.99
80_L84_D0.9030.99
19_V269_A0.9020.99
78_E81_E0.9010.99
68_Y85_T0.8910.98
32_R279_C0.8890.98
16_R269_A0.8880.98
18_E273_E0.8820.98
35_G92_I0.8800.98
93_D279_C0.8790.98
167_A183_G0.8790.98
157_T184_C0.8780.98
187_T199_H0.8780.98
85_T89_D0.8780.98
153_Y255_Y0.8750.98
134_R173_R0.8730.98
11_I149_L0.8700.98
36_L120_V0.8700.98
105_I110_V0.8680.98
11_I14_Q0.8640.98
265_P268_V0.8620.98
130_R135_A0.8570.98
9_K261_G0.8570.98
22_K276_L0.8520.98
139_R144_R0.8480.98
15_V270_T0.8480.98
226_I255_Y0.8450.98
86_L95_I0.8430.98
56_K60_E0.8420.98
165_I206_L0.8370.98
169_N173_R0.8370.98
149_L257_T0.8360.98
80_L110_V0.8330.98
278_A282_Y0.8310.98
147_V157_T0.8270.98
126_Y130_R0.8220.97
233_N241_V0.8180.97
38_V65_S0.8160.97
147_V151_E0.8140.97
74_T82_L0.8120.97
55_R69_D0.8110.97
149_L266_M0.8100.97
97_V114_I0.8080.97
216_I220_W0.8070.97
53_S56_K0.8050.97
141_C270_T0.8030.97
68_Y86_L0.8010.97
208_V233_N0.7950.97
197_R200_V0.7940.97
14_Q18_E0.7900.97
131_L139_R0.7880.97
246_F250_A0.7840.97
37_A66_R0.7820.97
165_I208_V0.7800.96
198_H201_E0.7750.96
214_G235_L0.7750.96
161_N194_K0.7730.96
167_A190_H0.7710.96
213_P232_I0.7700.96
6_I228_I0.7690.96
18_E21_Q0.7660.96
249_A252_R0.7560.96
161_N187_T0.7550.96
207_I230_V0.7520.96
144_R270_T0.7510.96
224_G253_A0.7470.96
213_P241_V0.7420.95
26_R31_L0.7400.95
147_V162_A0.7380.95
208_V244_V0.7380.95
13_Q60_E0.7380.95
19_V23_V0.7370.95
80_L105_I0.7340.95
124_H127_N0.7320.95
108_V135_A0.7310.95
12_A16_R0.7090.94
234_R240_V0.7070.94
146_I228_I0.7040.94
63_F272_I0.7030.94
79_L110_V0.7020.94
79_L105_I0.6980.94
23_V26_R0.6980.94
83_I110_V0.6970.94
49_I232_I0.6970.94
18_E148_T0.6950.93
71_P74_T0.6920.93
86_L92_I0.6860.93
53_S268_V0.6860.93
126_Y137_R0.6840.93
24_Q27_I0.6840.93
155_I226_I0.6780.93
164_V186_T0.6760.92
14_Q17_S0.6750.92
27_I30_G0.6740.92
38_V55_R0.6730.92
41_V79_L0.6720.92
229_D242_G0.6710.92
22_K273_E0.6700.92
49_I52_A0.6690.92
112_E130_R0.6690.92
95_I114_I0.6670.92
225_A254_S0.6660.92
273_E277_Q0.6610.92
224_G254_S0.6610.92
54_K98_Q0.6600.92
26_R276_L0.6600.92
162_A175_M0.6570.91
212_K217_P0.6560.91
158_F194_K0.6550.91
270_T273_E0.6500.91
108_V112_E0.6500.91
26_R32_R0.6500.91
227_V249_A0.6490.91
216_I221_I0.6440.91
208_V216_I0.6440.91
164_V179_L0.6430.91
19_V22_K0.6410.90
26_R279_C0.6410.90
18_E22_K0.6400.90
149_L265_P0.6380.90
183_G190_H0.6370.90
150_L155_I0.6370.90
53_S232_I0.6370.90
116_P124_H0.6360.90
175_M207_I0.6350.90
99_L107_N0.6340.90
58_C65_S0.6330.90
155_I205_L0.6290.90
39_V82_L0.6270.89
225_A253_A0.6250.89
125_P133_Q0.6250.89
143_P175_M0.6240.89
11_I148_T0.6220.89
83_I87_N0.6210.89
4_K153_Y0.6190.89
180_L183_G0.6190.89
206_L227_V0.6180.89
49_I234_R0.6160.89
109_K113_R0.6150.89
167_A192_F0.6140.88
185_T189_T0.6100.88
99_L123_F0.6090.88
78_E82_L0.6090.88
163_V200_V0.6090.88
90_N282_Y0.6080.88
23_V61_V0.6070.88
247_E251_K0.6070.88
117_D282_Y0.6060.88
51_V54_K0.6050.88
177_M180_L0.6050.88
10_T13_Q0.6040.88
79_L101_L0.6040.88
66_R91_T0.6020.87
56_K59_E0.6000.87
74_T105_I0.5980.87
197_R217_P0.5980.87
7_D261_G0.5960.87
125_P128_V0.5960.87
27_I32_R0.5950.87
23_V276_L0.5940.87
55_R65_S0.5940.87
8_G12_A0.5940.87
13_Q16_R0.5920.87
38_V67_S0.5910.86
26_R33_A0.5910.86
229_D260_P0.5910.86
150_L157_T0.5900.86
23_V31_L0.5890.86
16_R61_V0.5870.86
179_L207_I0.5870.86
46_A234_R0.5860.86
165_I200_V0.5850.86
120_V278_A0.5850.86
81_E84_D0.5850.86
191_R215_F0.5790.85
244_V256_I0.5790.85
168_S259_V0.5740.85
15_V273_E0.5710.85
128_V133_Q0.5700.84
20_A60_E0.5670.84
54_K265_P0.5660.84
158_F191_R0.5650.84
157_T182_A0.5630.84
117_D281_E0.5630.84
120_V275_T0.5630.84
191_R212_K0.5620.84
272_I275_T0.5620.84
228_I263_V0.5600.83
163_V206_L0.5590.83
180_L190_H0.5570.83
41_V101_L0.5570.83
23_V27_I0.5530.83
134_R181_L0.5530.83
232_I259_V0.5520.83
22_K25_A0.5520.83
40_L51_V0.5500.82
15_V148_T0.5480.82
171_V175_M0.5460.82
47_S98_Q0.5460.82
59_E63_F0.5450.82
232_I240_V0.5450.82
221_I253_A0.5450.82
213_P233_N0.5440.82
27_I31_L0.5430.82
250_A256_I0.5430.82
123_F128_V0.5390.81
45_P49_I0.5380.81
6_I152_R0.5360.81
232_I235_L0.5340.80
166_G231_G0.5330.80
130_R133_Q0.5330.80
173_R181_L0.5320.80
201_E219_D0.5310.80
155_I160_L0.5310.80
160_L226_I0.5300.80
127_N137_R0.5270.80
152_R155_I0.5270.80
218_G251_K0.5260.79
149_L153_Y0.5260.79
200_V216_I0.5260.79
17_S60_E0.5250.79
116_P126_Y0.5250.79
236_E239_K0.5240.79
30_G33_A0.5230.79
88_A115_H0.5230.79
68_Y74_T0.5230.79
39_V83_I0.5210.79
133_Q169_N0.5200.79
54_K268_V0.5200.79
223_E254_S0.5180.78
39_V97_V0.5180.78
149_L263_V0.5180.78
98_Q268_V0.5150.78
45_P234_R0.5150.78
214_G217_P0.5120.78
131_L136_P0.5090.77
176_S180_L0.5090.77
150_L226_I0.5090.77
35_G91_T0.5090.77
131_L137_R0.5070.77
15_V152_R0.5060.77
38_V54_K0.5060.77
37_A67_S0.5060.77
101_L105_I0.5040.77
200_V221_I0.5020.76
53_S57_A0.5010.76
177_M181_L0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4cjxA 2 0.9861 100 0.287 Contact Map
2c2xA 2 0.9653 100 0.289 Contact Map
4a5oA 2 0.9861 100 0.291 Contact Map
1b0aA 2 0.9965 100 0.292 Contact Map
3l07A 2 0.9826 100 0.293 Contact Map
4a26A 2 0.9861 100 0.305 Contact Map
3p2oA 2 0.9722 100 0.322 Contact Map
4b4uA 2 0.9792 100 0.322 Contact Map
1a4iA 2 0.9861 100 0.335 Contact Map
1edzA 2 0.941 100 0.422 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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