GREMLIN Database
ACCC - Biotin carboxylase
UniProt: P24182 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10276
Length: 449 (393)
Sequences: 18826 (10677)
Seq/√Len: 538.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
150_K175_D3.9231.00
68_S72_I3.3221.00
146_R179_A3.3051.00
174_G177_E3.2881.00
4_K27_K3.2151.00
141_D144_K3.2101.00
258_E262_K3.0831.00
93_E111_R2.9511.00
132_P202_K2.8601.00
280_E283_E2.8391.00
62_N65_A2.8351.00
254_R258_E2.6861.00
394_N397_V2.6151.00
93_E97_R2.5571.00
154_Y175_D2.5471.00
71_E98_S2.4631.00
173_R177_E2.4241.00
88_N114_G2.3771.00
134_S151_R2.3551.00
259_R262_K2.3351.00
250_P254_R2.2921.00
314_R319_Q2.2271.00
392_G397_V2.1931.00
125_K266_D2.1531.00
34_S50_C2.1501.00
123_M263_A2.1481.00
255_Y283_E2.1281.00
20_A23_E2.1011.00
261_A265_V2.0981.00
243_A303_I2.0831.00
218_G270_R2.0741.00
173_R205_E2.0681.00
7_I18_L2.0371.00
121_A125_K2.0221.00
94_Q98_S2.0131.00
67_I98_S2.0051.00
148_I151_R1.9971.00
118_S121_A1.9791.00
249_T252_L1.9671.00
175_D179_A1.9591.00
393_E397_V1.9521.00
63_I94_Q1.9261.00
259_R284_F1.9031.00
337_C402_M1.8951.00
255_Y259_R1.8601.00
353_K377_V1.8311.00
171_V203_Y1.8241.00
311_E322_S1.8161.00
310_K314_R1.7911.00
179_A183_S1.7701.00
5_I103_I1.7691.00
262_K265_V1.7331.00
23_E310_K1.7171.00
190_K196_D1.7121.00
142_M183_S1.7031.00
142_M179_A1.6931.00
67_I71_E1.6891.00
148_I152_I1.6821.00
78_I100_F1.6681.00
121_A124_K1.6651.00
186_R196_D1.6411.00
21_C28_T1.6231.00
117_V121_A1.6151.00
111_R118_S1.6091.00
252_L255_Y1.5961.00
65_A68_S1.5911.00
146_R175_D1.5871.00
20_A310_K1.5761.00
349_P352_G1.5651.00
215_L311_E1.5571.00
15_L44_L1.5551.00
96_E107_A1.5551.00
106_K109_T1.5541.00
64_P94_Q1.5431.00
69_A73_T1.5191.00
180_Q184_M1.5091.00
112_L122_A1.5051.00
263_A268_G1.5031.00
142_M146_R1.5011.00
142_M182_I1.5001.00
140_D144_K1.4801.00
95_V100_F1.4661.00
147_A151_R1.4591.00
34_S37_R1.4531.00
22_K46_D1.4461.00
49_V69_A1.4451.00
27_K47_E1.4311.00
264_C267_I1.4311.00
264_C268_G1.4241.00
302_M391_Y1.4231.00
372_Y375_Y1.4231.00
122_A125_K1.4221.00
147_A150_K1.4211.00
396_D400_A1.4161.00
252_L279_F1.4141.00
4_K29_V1.4031.00
255_Y258_E1.4021.00
122_A126_A1.4021.00
94_Q97_R1.4011.00
161_S197_M1.4001.00
212_I256_I1.3971.00
215_L272_A1.3971.00
70_A100_F1.3911.00
122_A266_D1.3851.00
134_S148_I1.3851.00
146_R150_K1.3841.00
68_S71_E1.3821.00
204_L287_I1.3641.00
302_M389_I1.3621.00
106_K270_R1.3491.00
5_I21_C1.3401.00
117_V135_D1.3391.00
108_E112_L1.3351.00
144_K147_A1.3331.00
368_E371_I1.3271.00
202_K285_Y1.3231.00
404_N408_E1.3231.00
112_L118_S1.3151.00
149_A156_V1.3141.00
254_R257_G1.3141.00
49_V73_T1.3121.00
149_A154_Y1.3121.00
96_E106_K1.3071.00
364_G367_W1.2981.00
293_I308_L1.2971.00
183_S187_A1.2891.00
143_D147_A1.2881.00
305_G328_V1.2861.00
19_R23_E1.2841.00
47_E73_T1.2831.00
32_H37_R1.2821.00
5_I26_I1.2821.00
154_Y174_G1.2791.00
126_A266_D1.2651.00
120_I201_E1.2611.00
305_G330_V1.2601.00
93_E108_E1.2581.00
374_G377_V1.2461.00
119_A123_M1.2411.00
113_M289_M1.2341.00
336_E387_K1.2301.00
124_K132_P1.2251.00
215_L315_I1.2181.00
345_N348_L1.2141.00
63_I67_I1.2081.00
214_V264_C1.2051.00
263_A267_I1.2011.00
30_A41_H1.1971.00
263_A266_D1.1941.00
340_N383_S1.1911.00
95_V102_F1.1901.00
143_D146_R1.1841.00
216_A222_A1.1831.00
250_P253_R1.1741.00
132_P152_I1.1661.00
397_V401_R1.1651.00
101_I317_A1.1541.00
78_I95_V1.1541.00
124_K130_C1.1511.00
403_K407_Q1.1451.00
170_R185_T1.1451.00
156_V200_M1.1431.00
390_C402_M1.1401.00
253_R257_G1.1361.00
251_E255_Y1.1341.00
335_V398_A1.1331.00
180_Q183_S1.1301.00
18_L44_L1.1301.00
205_E281_N1.1301.00
392_G401_R1.1231.00
70_A78_I1.1161.00
332_G391_Y1.1141.00
142_M186_R1.1081.00
399_I403_K1.1081.00
214_V275_F1.1051.00
226_A229_D1.1031.00
93_E107_A1.1021.00
335_V399_I1.0991.00
121_A133_G1.0971.00
4_K47_E1.0911.00
306_V311_E1.0881.00
140_D197_M1.0821.00
124_K135_D1.0811.00
84_F89_A1.0771.00
33_S37_R1.0741.00
219_Q320_P1.0731.00
29_V33_S1.0711.00
404_N407_Q1.0661.00
332_G393_E1.0631.00
354_I371_I1.0601.00
17_I79_H1.0591.00
353_K376_T1.0591.00
26_I317_A1.0551.00
176_A180_Q1.0531.00
120_I130_C1.0521.00
43_L372_Y1.0511.00
388_L405_A1.0491.00
400_A404_N1.0481.00
150_K179_A1.0361.00
96_E270_R1.0341.00
182_I198_V1.0291.00
157_I171_V1.0241.00
145_N182_I1.0221.00
248_I252_L1.0201.00
46_D49_V1.0201.00
388_L409_L1.0181.00
210_V279_F1.0151.00
123_M286_F1.0121.00
67_I94_Q1.0071.00
401_R404_N1.0071.00
48_T51_I1.0061.00
145_N178_L1.0051.00
249_T282_G1.0031.00
45_A48_T1.0011.00
92_A102_F1.0001.00
52_G61_L0.9931.00
108_E111_R0.9921.00
257_G261_A0.9881.00
63_I91_F0.9831.00
177_E180_Q0.9821.00
124_K134_S0.9781.00
152_I156_V0.9771.00
101_I218_G0.9751.00
115_D161_S0.9741.00
356_R360_P0.9691.00
359_A409_L0.9661.00
251_E254_R0.9661.00
138_L141_D0.9641.00
223_I323_I0.9621.00
24_L314_R0.9621.00
219_Q268_G0.9601.00
157_I203_Y0.9551.00
158_I198_V0.9551.00
30_A45_A0.9541.00
373_A376_T0.9511.00
371_I375_Y0.9481.00
29_V34_S0.9451.00
66_I95_V0.9391.00
216_A264_C0.9371.00
30_A34_S0.9341.00
212_I257_G0.9321.00
21_C313_L0.9301.00
5_I313_L0.9301.00
170_R181_S0.9281.00
338_R341_A0.9271.00
24_L307_D0.9221.00
4_K76_V0.9171.00
205_E280_E0.9151.00
373_A377_V0.9121.00
64_P68_S0.9101.00
128_V286_F0.9091.00
28_T32_H0.9081.00
69_A75_A0.9011.00
162_G195_N0.9011.00
95_V98_S0.8991.00
146_R183_S0.8981.00
117_V161_S0.8971.00
129_P259_R0.8961.00
182_I186_R0.8951.00
129_P283_E0.8941.00
279_F284_F0.8941.00
275_F289_M0.8931.00
392_G398_A0.8931.00
138_L148_I0.8881.00
202_K283_E0.8881.00
326_E329_H0.8861.00
325_Q328_V0.8831.00
144_K148_I0.8821.00
154_Y178_L0.8821.00
226_A230_C0.8771.00
365_V405_A0.8761.00
367_W386_G0.8741.00
170_R184_M0.8741.00
225_L228_R0.8721.00
405_A408_E0.8711.00
91_F95_V0.8701.00
32_H35_A0.8691.00
24_L310_K0.8661.00
7_I21_C0.8661.00
314_R317_A0.8651.00
176_A179_A0.8591.00
301_E389_I0.8511.00
21_C79_H0.8501.00
124_K133_G0.8461.00
18_L45_A0.8461.00
313_L317_A0.8461.00
247_G279_F0.8421.00
256_I284_F0.8421.00
265_V268_G0.8401.00
47_E50_C0.8391.00
115_D197_M0.8381.00
172_V181_S0.8381.00
346_T351_P0.8371.00
109_T270_R0.8321.00
204_L285_Y0.8311.00
31_V51_I0.8311.00
215_L224_Y0.8311.00
225_L229_D0.8281.00
311_E314_R0.8261.00
390_C405_A0.8261.00
79_H312_Q0.8231.00
365_V390_C0.8231.00
184_M188_E0.8161.00
103_I313_L0.8161.00
30_A35_A0.8161.00
6_V31_V0.8121.00
227_E230_C0.8101.00
149_A182_I0.8101.00
18_L28_T0.8081.00
117_V197_M0.8051.00
149_A178_L0.8001.00
32_H48_T0.7991.00
67_I97_R0.7931.00
158_I182_I0.7911.00
145_N200_M0.7841.00
356_R373_A0.7831.00
184_M187_A0.7821.00
134_S138_L0.7791.00
121_A135_D0.7791.00
158_I181_S0.7781.00
220_G265_V0.7781.00
149_A153_G0.7781.00
70_A95_V0.7771.00
357_F360_P0.7771.00
6_V70_A0.7691.00
339_I406_L0.7691.00
113_M267_I0.7681.00
90_N111_R0.7681.00
352_G356_R0.7661.00
106_K268_G0.7641.00
356_R410_I0.7641.00
43_L48_T0.7641.00
8_A91_F0.7641.00
96_E108_E0.7631.00
258_E261_A0.7621.00
227_E253_R0.7561.00
138_L145_N0.7561.00
364_G368_E0.7531.00
30_A33_S0.7521.00
29_V32_H0.7521.00
26_I29_V0.7511.00
170_R188_E0.7501.00
42_V48_T0.7491.00
4_K73_T0.7471.00
134_S144_K0.7451.00
331_R393_E0.7411.00
355_T412_D0.7411.00
256_I259_R0.7411.00
212_I260_C0.7401.00
222_A261_A0.7391.00
260_C264_C0.7361.00
327_E330_V0.7321.00
22_K28_T0.7321.00
138_L144_K0.7291.00
132_P151_R0.7251.00
264_C273_G0.7251.00
331_R391_Y0.7231.00
243_A299_V0.7221.00
358_H361_G0.7221.00
224_Y257_G0.7211.00
255_Y284_F0.7191.00
157_I169_M0.7181.00
15_L41_H0.7151.00
262_K266_D0.7131.00
89_A111_R0.7131.00
30_A37_R0.7111.00
357_F361_G0.7111.00
356_R412_D0.7101.00
356_R359_A0.7101.00
352_G412_D0.7081.00
156_V172_V0.7061.00
49_V52_G0.7021.00
28_T33_S0.7011.00
96_E102_F0.7001.00
242_E395_R0.6981.00
336_E340_N0.6981.00
348_L351_P0.6981.00
4_K74_G0.6961.00
298_P301_E0.6951.00
43_L46_D0.6921.00
241_E299_V0.6921.00
90_N94_Q0.6921.00
152_I202_K0.6901.00
189_A196_D0.6901.00
397_V400_A0.6891.00
337_C340_N0.6871.00
51_I69_A0.6871.00
158_I172_V0.6861.00
337_C341_A0.6861.00
260_C277_F0.6851.00
46_D50_C0.6841.00
117_V199_Y0.6811.00
142_M178_L0.6801.00
120_I131_V0.6781.00
333_H395_R0.6751.00
213_Q272_A0.6731.00
214_V273_G0.6731.00
27_K46_D0.6731.00
278_L287_I0.6721.00
362_G365_V0.6711.00
217_D220_G0.6701.00
135_D197_M0.6701.00
305_G329_H0.6701.00
336_E341_A0.6681.00
355_T410_I0.6651.00
240_V337_C0.6651.00
370_H375_Y0.6631.00
323_I328_V0.6621.00
228_R242_E0.6621.00
225_L303_I0.6621.00
24_L313_L0.6611.00
142_M145_N0.6591.00
83_G86_S0.6591.00
47_E51_I0.6581.00
92_A96_E0.6571.00
208_R279_F0.6561.00
216_A265_V0.6561.00
216_A270_R0.6531.00
210_V245_A0.6511.00
353_K356_R0.6501.00
305_G331_R0.6491.00
347_F350_S0.6471.00
363_F368_E0.6461.00
48_T52_G0.6451.00
93_E96_E0.6431.00
131_V204_L0.6431.00
115_D162_G0.6431.00
269_Y291_T0.6421.00
226_A303_I0.6421.00
4_K28_T0.6391.00
6_V75_A0.6391.00
350_S354_I0.6381.00
31_V34_S0.6381.00
314_R318_G0.6371.00
323_I327_E0.6371.00
33_S36_D0.6371.00
204_L280_E0.6361.00
227_E245_A0.6351.00
20_A24_L0.6351.00
67_I100_F0.6341.00
248_I253_R0.6311.00
46_D51_I0.6301.00
340_N344_P0.6261.00
225_L230_C0.6261.00
337_C342_E0.6251.00
31_V66_I0.6251.00
303_I330_V0.6251.00
337_C344_P0.6231.00
71_E97_R0.6211.00
342_E349_P0.6211.00
260_C275_F0.6211.00
312_Q316_A0.6201.00
27_K30_A0.6191.00
282_G285_Y0.6181.00
311_E323_I0.6181.00
357_F409_L0.6171.00
107_A111_R0.6171.00
21_C26_I0.6131.00
360_P405_A0.6081.00
92_A95_V0.6081.00
280_E285_Y0.6081.00
345_N351_P0.6061.00
224_Y261_A0.6031.00
149_A152_I0.6021.00
40_K372_Y0.6021.00
208_R247_G0.6011.00
101_I270_R0.5991.00
269_Y273_G0.5981.00
263_A289_M0.5961.00
153_G175_D0.5951.00
65_A69_A0.5931.00
214_V260_C0.5921.00
298_P336_E0.5921.00
150_K154_Y0.5921.00
299_V302_M0.5901.00
390_C398_A0.5901.00
219_Q265_V0.5891.00
341_A344_P0.5891.00
311_E327_E0.5891.00
326_E330_V0.5880.99
29_V37_R0.5880.99
29_V35_A0.5880.99
31_V35_A0.5870.99
221_N265_V0.5870.99
358_H410_I0.5870.99
158_I178_L0.5870.99
363_F366_R0.5870.99
172_V178_L0.5860.99
380_Y411_I0.5850.99
395_R399_I0.5850.99
216_A221_N0.5840.99
5_I309_I0.5840.99
319_Q323_I0.5840.99
396_D399_I0.5830.99
386_G409_L0.5830.99
185_T198_V0.5830.99
320_P323_I0.5830.99
259_R263_A0.5810.99
68_S98_S0.5780.99
181_S185_T0.5780.99
339_I409_L0.5770.99
238_K241_E0.5750.99
34_S38_D0.5740.99
115_D118_S0.5730.99
224_Y325_Q0.5730.99
172_V177_E0.5730.99
233_Q238_K0.5710.99
364_G401_R0.5710.99
304_T328_V0.5680.99
336_E339_I0.5670.99
398_A402_M0.5660.99
28_T35_A0.5640.99
357_F378_P0.5640.99
167_R188_E0.5630.99
185_T189_A0.5610.99
338_R342_E0.5610.99
329_H332_G0.5610.99
131_V287_I0.5590.99
216_A220_G0.5580.99
239_V340_N0.5580.99
122_A267_I0.5580.99
149_A200_M0.5580.99
13_I293_I0.5560.99
169_M236_H0.5540.99
217_D321_L0.5520.99
181_S184_M0.5520.99
158_I200_M0.5510.99
372_Y379_P0.5500.99
315_I321_L0.5500.99
186_R198_V0.5490.99
112_L125_K0.5460.99
173_R203_Y0.5460.99
350_S353_K0.5450.99
351_P354_I0.5400.99
345_N349_P0.5390.99
145_N148_I0.5390.99
314_R322_S0.5370.99
45_A49_V0.5370.99
255_Y262_K0.5360.99
61_L91_F0.5360.99
78_I102_F0.5350.99
229_D245_A0.5340.99
360_P364_G0.5340.99
63_I89_A0.5310.99
225_L304_T0.5310.99
45_A50_C0.5300.99
341_A352_G0.5300.99
28_T34_S0.5290.99
177_E181_S0.5290.99
304_T330_V0.5280.99
368_E374_G0.5280.99
313_L316_A0.5270.99
66_I78_I0.5260.99
44_L47_E0.5240.99
257_G262_K0.5230.99
346_T353_K0.5220.99
8_A66_I0.5220.99
288_E292_R0.5210.99
346_T352_G0.5210.99
226_A330_V0.5210.99
219_Q318_G0.5190.99
363_F367_W0.5190.99
270_R315_I0.5170.99
358_H373_A0.5170.99
402_M406_L0.5170.99
123_M128_V0.5170.99
256_I260_C0.5150.99
148_I200_M0.5140.99
226_A328_V0.5140.99
20_A307_D0.5130.99
112_L291_T0.5120.99
156_V202_K0.5120.99
116_K159_K0.5100.99
44_L50_C0.5100.99
249_T279_F0.5090.99
171_V236_H0.5090.99
161_S199_Y0.5080.99
12_E387_K0.5070.99
262_K267_I0.5070.99
154_Y173_R0.5060.99
367_W409_L0.5050.98
178_L182_I0.5040.98
110_I291_T0.5030.98
51_I65_A0.5020.98
37_R40_K0.5020.98
272_A293_I0.5010.98
119_A286_F0.5010.98
354_I357_F0.5010.98
407_Q410_I0.5010.98
223_I226_A0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3n6rA 1 0.8396 100 0.302 Contact Map
4rcnA 6 0.9109 100 0.307 Contact Map
3u9tA 3 0.9666 100 0.309 Contact Map
3va7A 1 0.833 100 0.31 Contact Map
4qshA 4 0.8597 100 0.314 Contact Map
2qf7A 4 0.8953 100 0.315 Contact Map
3hblA 4 0.9933 100 0.32 Contact Map
4mv4A 2 0.9777 100 0.321 Contact Map
2vpqA 2 0.9844 100 0.331 Contact Map
2dzdA 2 0.9933 100 0.332 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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