ACCC - ECOLI - GREMLIN Contacts

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ACCC - Biotin carboxylase

UniProt:	P24182	Sequences: MLDKIVIANRGEIALRILRACKELGIKTVAVHSSADRDLKHVLLADETVCIGPAPSVKSYLNIPAIISAAEITGAVAIHPGYGFLSENANFAEQVERSGFIFIGPKAETIRLMGDKVSAIAAMKKAGVPCVPGSDGPLGDDMDKNRAIAKRIGYPVIIKASGGGGGRGMRVVRGDAELAQSISMTRAEAKAAFSNDMVYMEKYLENPRHVEIQVLADGQGNAIYLAERDCSMQRRHQKVVEEAPAPGITPELRRYIGERCAKACVDIGYRGAGTFEFLFENGEFYFIEMNTRIQVEHPVTEMITGVDLIKEQLRIAAGQPLSIKQEEVHVRGHAVECRINAEDPNTFLPSPGKITRFHAPGGFGVRWESHIYAGYTVPPYYDSMIGKLICYGENRDVAIARMKNALQELIIDGIKTNVDLQIRIMNDENFQHGGTNIHYLEKKLGLQEK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10276
Length:	449 (393)
Sequences:	18826 (10677)
Seq/√Len:	538.6

ECOLI - ACCC PUR2 PURT PURK CARB DDLB
BACSU - ACCC2 ACCC1 PUR2 BACD PURT PURK PYC CARY CARB
HALSA - Q9HQ67 Q9HPP8 Q9HRM3 CARB
SULSO - Q97VY6 Q7LXR2 PURT PURK CARB

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
150_K	175_D	3.923	1.00
68_S	72_I	3.322	1.00
146_R	179_A	3.305	1.00
174_G	177_E	3.288	1.00
4_K	27_K	3.215	1.00
141_D	144_K	3.210	1.00
258_E	262_K	3.083	1.00
93_E	111_R	2.951	1.00
132_P	202_K	2.860	1.00
280_E	283_E	2.839	1.00
62_N	65_A	2.835	1.00
254_R	258_E	2.686	1.00
394_N	397_V	2.615	1.00
93_E	97_R	2.557	1.00
154_Y	175_D	2.547	1.00
71_E	98_S	2.463	1.00
173_R	177_E	2.424	1.00
88_N	114_G	2.377	1.00
134_S	151_R	2.355	1.00
259_R	262_K	2.335	1.00
250_P	254_R	2.292	1.00
314_R	319_Q	2.227	1.00
392_G	397_V	2.193	1.00
125_K	266_D	2.153	1.00
34_S	50_C	2.150	1.00
123_M	263_A	2.148	1.00
255_Y	283_E	2.128	1.00
20_A	23_E	2.101	1.00
261_A	265_V	2.098	1.00
243_A	303_I	2.083	1.00
218_G	270_R	2.074	1.00
173_R	205_E	2.068	1.00
7_I	18_L	2.037	1.00
121_A	125_K	2.022	1.00
94_Q	98_S	2.013	1.00
67_I	98_S	2.005	1.00
148_I	151_R	1.997	1.00
118_S	121_A	1.979	1.00
249_T	252_L	1.967	1.00
175_D	179_A	1.959	1.00
393_E	397_V	1.952	1.00
63_I	94_Q	1.926	1.00
259_R	284_F	1.903	1.00
337_C	402_M	1.895	1.00
255_Y	259_R	1.860	1.00
353_K	377_V	1.831	1.00
171_V	203_Y	1.824	1.00
311_E	322_S	1.816	1.00
310_K	314_R	1.791	1.00
179_A	183_S	1.770	1.00
5_I	103_I	1.769	1.00
262_K	265_V	1.733	1.00
23_E	310_K	1.717	1.00
190_K	196_D	1.712	1.00
142_M	183_S	1.703	1.00
142_M	179_A	1.693	1.00
67_I	71_E	1.689	1.00
148_I	152_I	1.682	1.00
78_I	100_F	1.668	1.00
121_A	124_K	1.665	1.00
186_R	196_D	1.641	1.00
21_C	28_T	1.623	1.00
117_V	121_A	1.615	1.00
111_R	118_S	1.609	1.00
252_L	255_Y	1.596	1.00
65_A	68_S	1.591	1.00
146_R	175_D	1.587	1.00
20_A	310_K	1.576	1.00
349_P	352_G	1.565	1.00
215_L	311_E	1.557	1.00
15_L	44_L	1.555	1.00
96_E	107_A	1.555	1.00
106_K	109_T	1.554	1.00
64_P	94_Q	1.543	1.00
69_A	73_T	1.519	1.00
180_Q	184_M	1.509	1.00
112_L	122_A	1.505	1.00
263_A	268_G	1.503	1.00
142_M	146_R	1.501	1.00
142_M	182_I	1.500	1.00
140_D	144_K	1.480	1.00
95_V	100_F	1.466	1.00
147_A	151_R	1.459	1.00
34_S	37_R	1.453	1.00
22_K	46_D	1.446	1.00
49_V	69_A	1.445	1.00
27_K	47_E	1.431	1.00
264_C	267_I	1.431	1.00
264_C	268_G	1.424	1.00
302_M	391_Y	1.423	1.00
372_Y	375_Y	1.423	1.00
122_A	125_K	1.422	1.00
147_A	150_K	1.421	1.00
396_D	400_A	1.416	1.00
252_L	279_F	1.414	1.00
4_K	29_V	1.403	1.00
255_Y	258_E	1.402	1.00
122_A	126_A	1.402	1.00
94_Q	97_R	1.401	1.00
161_S	197_M	1.400	1.00
212_I	256_I	1.397	1.00
215_L	272_A	1.397	1.00
70_A	100_F	1.391	1.00
122_A	266_D	1.385	1.00
134_S	148_I	1.385	1.00
146_R	150_K	1.384	1.00
68_S	71_E	1.382	1.00
204_L	287_I	1.364	1.00
302_M	389_I	1.362	1.00
106_K	270_R	1.349	1.00
5_I	21_C	1.340	1.00
117_V	135_D	1.339	1.00
108_E	112_L	1.335	1.00
144_K	147_A	1.333	1.00
368_E	371_I	1.327	1.00
202_K	285_Y	1.323	1.00
404_N	408_E	1.323	1.00
112_L	118_S	1.315	1.00
149_A	156_V	1.314	1.00
254_R	257_G	1.314	1.00
49_V	73_T	1.312	1.00
149_A	154_Y	1.312	1.00
96_E	106_K	1.307	1.00
364_G	367_W	1.298	1.00
293_I	308_L	1.297	1.00
183_S	187_A	1.289	1.00
143_D	147_A	1.288	1.00
305_G	328_V	1.286	1.00
19_R	23_E	1.284	1.00
47_E	73_T	1.283	1.00
32_H	37_R	1.282	1.00
5_I	26_I	1.282	1.00
154_Y	174_G	1.279	1.00
126_A	266_D	1.265	1.00
120_I	201_E	1.261	1.00
305_G	330_V	1.260	1.00
93_E	108_E	1.258	1.00
374_G	377_V	1.246	1.00
119_A	123_M	1.241	1.00
113_M	289_M	1.234	1.00
336_E	387_K	1.230	1.00
124_K	132_P	1.225	1.00
215_L	315_I	1.218	1.00
345_N	348_L	1.214	1.00
63_I	67_I	1.208	1.00
214_V	264_C	1.205	1.00
263_A	267_I	1.201	1.00
30_A	41_H	1.197	1.00
263_A	266_D	1.194	1.00
340_N	383_S	1.191	1.00
95_V	102_F	1.190	1.00
143_D	146_R	1.184	1.00
216_A	222_A	1.183	1.00
250_P	253_R	1.174	1.00
132_P	152_I	1.166	1.00
397_V	401_R	1.165	1.00
101_I	317_A	1.154	1.00
78_I	95_V	1.154	1.00
124_K	130_C	1.151	1.00
403_K	407_Q	1.145	1.00
170_R	185_T	1.145	1.00
156_V	200_M	1.143	1.00
390_C	402_M	1.140	1.00
253_R	257_G	1.136	1.00
251_E	255_Y	1.134	1.00
335_V	398_A	1.133	1.00
180_Q	183_S	1.130	1.00
18_L	44_L	1.130	1.00
205_E	281_N	1.130	1.00
392_G	401_R	1.123	1.00
70_A	78_I	1.116	1.00
332_G	391_Y	1.114	1.00
142_M	186_R	1.108	1.00
399_I	403_K	1.108	1.00
214_V	275_F	1.105	1.00
226_A	229_D	1.103	1.00
93_E	107_A	1.102	1.00
335_V	399_I	1.099	1.00
121_A	133_G	1.097	1.00
4_K	47_E	1.091	1.00
306_V	311_E	1.088	1.00
140_D	197_M	1.082	1.00
124_K	135_D	1.081	1.00
84_F	89_A	1.077	1.00
33_S	37_R	1.074	1.00
219_Q	320_P	1.073	1.00
29_V	33_S	1.071	1.00
404_N	407_Q	1.066	1.00
332_G	393_E	1.063	1.00
354_I	371_I	1.060	1.00
17_I	79_H	1.059	1.00
353_K	376_T	1.059	1.00
26_I	317_A	1.055	1.00
176_A	180_Q	1.053	1.00
120_I	130_C	1.052	1.00
43_L	372_Y	1.051	1.00
388_L	405_A	1.049	1.00
400_A	404_N	1.048	1.00
150_K	179_A	1.036	1.00
96_E	270_R	1.034	1.00
182_I	198_V	1.029	1.00
157_I	171_V	1.024	1.00
145_N	182_I	1.022	1.00
248_I	252_L	1.020	1.00
46_D	49_V	1.020	1.00
388_L	409_L	1.018	1.00
210_V	279_F	1.015	1.00
123_M	286_F	1.012	1.00
67_I	94_Q	1.007	1.00
401_R	404_N	1.007	1.00
48_T	51_I	1.006	1.00
145_N	178_L	1.005	1.00
249_T	282_G	1.003	1.00
45_A	48_T	1.001	1.00
92_A	102_F	1.000	1.00
52_G	61_L	0.993	1.00
108_E	111_R	0.992	1.00
257_G	261_A	0.988	1.00
63_I	91_F	0.983	1.00
177_E	180_Q	0.982	1.00
124_K	134_S	0.978	1.00
152_I	156_V	0.977	1.00
101_I	218_G	0.975	1.00
115_D	161_S	0.974	1.00
356_R	360_P	0.969	1.00
359_A	409_L	0.966	1.00
251_E	254_R	0.966	1.00
138_L	141_D	0.964	1.00
223_I	323_I	0.962	1.00
24_L	314_R	0.962	1.00
219_Q	268_G	0.960	1.00
157_I	203_Y	0.955	1.00
158_I	198_V	0.955	1.00
30_A	45_A	0.954	1.00
373_A	376_T	0.951	1.00
371_I	375_Y	0.948	1.00
29_V	34_S	0.945	1.00
66_I	95_V	0.939	1.00
216_A	264_C	0.937	1.00
30_A	34_S	0.934	1.00
212_I	257_G	0.932	1.00
21_C	313_L	0.930	1.00
5_I	313_L	0.930	1.00
170_R	181_S	0.928	1.00
338_R	341_A	0.927	1.00
24_L	307_D	0.922	1.00
4_K	76_V	0.917	1.00
205_E	280_E	0.915	1.00
373_A	377_V	0.912	1.00
64_P	68_S	0.910	1.00
128_V	286_F	0.909	1.00
28_T	32_H	0.908	1.00
69_A	75_A	0.901	1.00
162_G	195_N	0.901	1.00
95_V	98_S	0.899	1.00
146_R	183_S	0.898	1.00
117_V	161_S	0.897	1.00
129_P	259_R	0.896	1.00
182_I	186_R	0.895	1.00
129_P	283_E	0.894	1.00
279_F	284_F	0.894	1.00
275_F	289_M	0.893	1.00
392_G	398_A	0.893	1.00
138_L	148_I	0.888	1.00
202_K	283_E	0.888	1.00
326_E	329_H	0.886	1.00
325_Q	328_V	0.883	1.00
144_K	148_I	0.882	1.00
154_Y	178_L	0.882	1.00
226_A	230_C	0.877	1.00
365_V	405_A	0.876	1.00
367_W	386_G	0.874	1.00
170_R	184_M	0.874	1.00
225_L	228_R	0.872	1.00
405_A	408_E	0.871	1.00
91_F	95_V	0.870	1.00
32_H	35_A	0.869	1.00
24_L	310_K	0.866	1.00
7_I	21_C	0.866	1.00
314_R	317_A	0.865	1.00
176_A	179_A	0.859	1.00
301_E	389_I	0.851	1.00
21_C	79_H	0.850	1.00
124_K	133_G	0.846	1.00
18_L	45_A	0.846	1.00
313_L	317_A	0.846	1.00
247_G	279_F	0.842	1.00
256_I	284_F	0.842	1.00
265_V	268_G	0.840	1.00
47_E	50_C	0.839	1.00
115_D	197_M	0.838	1.00
172_V	181_S	0.838	1.00
346_T	351_P	0.837	1.00
109_T	270_R	0.832	1.00
204_L	285_Y	0.831	1.00
31_V	51_I	0.831	1.00
215_L	224_Y	0.831	1.00
225_L	229_D	0.828	1.00
311_E	314_R	0.826	1.00
390_C	405_A	0.826	1.00
79_H	312_Q	0.823	1.00
365_V	390_C	0.823	1.00
184_M	188_E	0.816	1.00
103_I	313_L	0.816	1.00
30_A	35_A	0.816	1.00
6_V	31_V	0.812	1.00
227_E	230_C	0.810	1.00
149_A	182_I	0.810	1.00
18_L	28_T	0.808	1.00
117_V	197_M	0.805	1.00
149_A	178_L	0.800	1.00
32_H	48_T	0.799	1.00
67_I	97_R	0.793	1.00
158_I	182_I	0.791	1.00
145_N	200_M	0.784	1.00
356_R	373_A	0.783	1.00
184_M	187_A	0.782	1.00
134_S	138_L	0.779	1.00
121_A	135_D	0.779	1.00
158_I	181_S	0.778	1.00
220_G	265_V	0.778	1.00
149_A	153_G	0.778	1.00
70_A	95_V	0.777	1.00
357_F	360_P	0.777	1.00
6_V	70_A	0.769	1.00
339_I	406_L	0.769	1.00
113_M	267_I	0.768	1.00
90_N	111_R	0.768	1.00
352_G	356_R	0.766	1.00
106_K	268_G	0.764	1.00
356_R	410_I	0.764	1.00
43_L	48_T	0.764	1.00
8_A	91_F	0.764	1.00
96_E	108_E	0.763	1.00
258_E	261_A	0.762	1.00
227_E	253_R	0.756	1.00
138_L	145_N	0.756	1.00
364_G	368_E	0.753	1.00
30_A	33_S	0.752	1.00
29_V	32_H	0.752	1.00
26_I	29_V	0.751	1.00
170_R	188_E	0.750	1.00
42_V	48_T	0.749	1.00
4_K	73_T	0.747	1.00
134_S	144_K	0.745	1.00
331_R	393_E	0.741	1.00
355_T	412_D	0.741	1.00
256_I	259_R	0.741	1.00
212_I	260_C	0.740	1.00
222_A	261_A	0.739	1.00
260_C	264_C	0.736	1.00
327_E	330_V	0.732	1.00
22_K	28_T	0.732	1.00
138_L	144_K	0.729	1.00
132_P	151_R	0.725	1.00
264_C	273_G	0.725	1.00
331_R	391_Y	0.723	1.00
243_A	299_V	0.722	1.00
358_H	361_G	0.722	1.00
224_Y	257_G	0.721	1.00
255_Y	284_F	0.719	1.00
157_I	169_M	0.718	1.00
15_L	41_H	0.715	1.00
262_K	266_D	0.713	1.00
89_A	111_R	0.713	1.00
30_A	37_R	0.711	1.00
357_F	361_G	0.711	1.00
356_R	412_D	0.710	1.00
356_R	359_A	0.710	1.00
352_G	412_D	0.708	1.00
156_V	172_V	0.706	1.00
49_V	52_G	0.702	1.00
28_T	33_S	0.701	1.00
96_E	102_F	0.700	1.00
242_E	395_R	0.698	1.00
336_E	340_N	0.698	1.00
348_L	351_P	0.698	1.00
4_K	74_G	0.696	1.00
298_P	301_E	0.695	1.00
43_L	46_D	0.692	1.00
241_E	299_V	0.692	1.00
90_N	94_Q	0.692	1.00
152_I	202_K	0.690	1.00
189_A	196_D	0.690	1.00
397_V	400_A	0.689	1.00
337_C	340_N	0.687	1.00
51_I	69_A	0.687	1.00
158_I	172_V	0.686	1.00
337_C	341_A	0.686	1.00
260_C	277_F	0.685	1.00
46_D	50_C	0.684	1.00
117_V	199_Y	0.681	1.00
142_M	178_L	0.680	1.00
120_I	131_V	0.678	1.00
333_H	395_R	0.675	1.00
213_Q	272_A	0.673	1.00
214_V	273_G	0.673	1.00
27_K	46_D	0.673	1.00
278_L	287_I	0.672	1.00
362_G	365_V	0.671	1.00
217_D	220_G	0.670	1.00
135_D	197_M	0.670	1.00
305_G	329_H	0.670	1.00
336_E	341_A	0.668	1.00
355_T	410_I	0.665	1.00
240_V	337_C	0.665	1.00
370_H	375_Y	0.663	1.00
323_I	328_V	0.662	1.00
228_R	242_E	0.662	1.00
225_L	303_I	0.662	1.00
24_L	313_L	0.661	1.00
142_M	145_N	0.659	1.00
83_G	86_S	0.659	1.00
47_E	51_I	0.658	1.00
92_A	96_E	0.657	1.00
208_R	279_F	0.656	1.00
216_A	265_V	0.656	1.00
216_A	270_R	0.653	1.00
210_V	245_A	0.651	1.00
353_K	356_R	0.650	1.00
305_G	331_R	0.649	1.00
347_F	350_S	0.647	1.00
363_F	368_E	0.646	1.00
48_T	52_G	0.645	1.00
93_E	96_E	0.643	1.00
131_V	204_L	0.643	1.00
115_D	162_G	0.643	1.00
269_Y	291_T	0.642	1.00
226_A	303_I	0.642	1.00
4_K	28_T	0.639	1.00
6_V	75_A	0.639	1.00
350_S	354_I	0.638	1.00
31_V	34_S	0.638	1.00
314_R	318_G	0.637	1.00
323_I	327_E	0.637	1.00
33_S	36_D	0.637	1.00
204_L	280_E	0.636	1.00
227_E	245_A	0.635	1.00
20_A	24_L	0.635	1.00
67_I	100_F	0.634	1.00
248_I	253_R	0.631	1.00
46_D	51_I	0.630	1.00
340_N	344_P	0.626	1.00
225_L	230_C	0.626	1.00
337_C	342_E	0.625	1.00
31_V	66_I	0.625	1.00
303_I	330_V	0.625	1.00
337_C	344_P	0.623	1.00
71_E	97_R	0.621	1.00
342_E	349_P	0.621	1.00
260_C	275_F	0.621	1.00
312_Q	316_A	0.620	1.00
27_K	30_A	0.619	1.00
282_G	285_Y	0.618	1.00
311_E	323_I	0.618	1.00
357_F	409_L	0.617	1.00
107_A	111_R	0.617	1.00
21_C	26_I	0.613	1.00
360_P	405_A	0.608	1.00
92_A	95_V	0.608	1.00
280_E	285_Y	0.608	1.00
345_N	351_P	0.606	1.00
224_Y	261_A	0.603	1.00
149_A	152_I	0.602	1.00
40_K	372_Y	0.602	1.00
208_R	247_G	0.601	1.00
101_I	270_R	0.599	1.00
269_Y	273_G	0.598	1.00
263_A	289_M	0.596	1.00
153_G	175_D	0.595	1.00
65_A	69_A	0.593	1.00
214_V	260_C	0.592	1.00
298_P	336_E	0.592	1.00
150_K	154_Y	0.592	1.00
299_V	302_M	0.590	1.00
390_C	398_A	0.590	1.00
219_Q	265_V	0.589	1.00
341_A	344_P	0.589	1.00
311_E	327_E	0.589	1.00
326_E	330_V	0.588	0.99
29_V	37_R	0.588	0.99
29_V	35_A	0.588	0.99
31_V	35_A	0.587	0.99
221_N	265_V	0.587	0.99
358_H	410_I	0.587	0.99
158_I	178_L	0.587	0.99
363_F	366_R	0.587	0.99
172_V	178_L	0.586	0.99
380_Y	411_I	0.585	0.99
395_R	399_I	0.585	0.99
216_A	221_N	0.584	0.99
5_I	309_I	0.584	0.99
319_Q	323_I	0.584	0.99
396_D	399_I	0.583	0.99
386_G	409_L	0.583	0.99
185_T	198_V	0.583	0.99
320_P	323_I	0.583	0.99
259_R	263_A	0.581	0.99
68_S	98_S	0.578	0.99
181_S	185_T	0.578	0.99
339_I	409_L	0.577	0.99
238_K	241_E	0.575	0.99
34_S	38_D	0.574	0.99
115_D	118_S	0.573	0.99
224_Y	325_Q	0.573	0.99
172_V	177_E	0.573	0.99
233_Q	238_K	0.571	0.99
364_G	401_R	0.571	0.99
304_T	328_V	0.568	0.99
336_E	339_I	0.567	0.99
398_A	402_M	0.566	0.99
28_T	35_A	0.564	0.99
357_F	378_P	0.564	0.99
167_R	188_E	0.563	0.99
185_T	189_A	0.561	0.99
338_R	342_E	0.561	0.99
329_H	332_G	0.561	0.99
131_V	287_I	0.559	0.99
216_A	220_G	0.558	0.99
239_V	340_N	0.558	0.99
122_A	267_I	0.558	0.99
149_A	200_M	0.558	0.99
13_I	293_I	0.556	0.99
169_M	236_H	0.554	0.99
217_D	321_L	0.552	0.99
181_S	184_M	0.552	0.99
158_I	200_M	0.551	0.99
372_Y	379_P	0.550	0.99
315_I	321_L	0.550	0.99
186_R	198_V	0.549	0.99
112_L	125_K	0.546	0.99
173_R	203_Y	0.546	0.99
350_S	353_K	0.545	0.99
351_P	354_I	0.540	0.99
345_N	349_P	0.539	0.99
145_N	148_I	0.539	0.99
314_R	322_S	0.537	0.99
45_A	49_V	0.537	0.99
255_Y	262_K	0.536	0.99
61_L	91_F	0.536	0.99
78_I	102_F	0.535	0.99
229_D	245_A	0.534	0.99
360_P	364_G	0.534	0.99
63_I	89_A	0.531	0.99
225_L	304_T	0.531	0.99
45_A	50_C	0.530	0.99
341_A	352_G	0.530	0.99
28_T	34_S	0.529	0.99
177_E	181_S	0.529	0.99
304_T	330_V	0.528	0.99
368_E	374_G	0.528	0.99
313_L	316_A	0.527	0.99
66_I	78_I	0.526	0.99
44_L	47_E	0.524	0.99
257_G	262_K	0.523	0.99
346_T	353_K	0.522	0.99
8_A	66_I	0.522	0.99
288_E	292_R	0.521	0.99
346_T	352_G	0.521	0.99
226_A	330_V	0.521	0.99
219_Q	318_G	0.519	0.99
363_F	367_W	0.519	0.99
270_R	315_I	0.517	0.99
358_H	373_A	0.517	0.99
402_M	406_L	0.517	0.99
123_M	128_V	0.517	0.99
256_I	260_C	0.515	0.99
148_I	200_M	0.514	0.99
226_A	328_V	0.514	0.99
20_A	307_D	0.513	0.99
112_L	291_T	0.512	0.99
156_V	202_K	0.512	0.99
116_K	159_K	0.510	0.99
44_L	50_C	0.510	0.99
249_T	279_F	0.509	0.99
171_V	236_H	0.509	0.99
161_S	199_Y	0.508	0.99
12_E	387_K	0.507	0.99
262_K	267_I	0.507	0.99
154_Y	173_R	0.506	0.99
367_W	409_L	0.505	0.98
178_L	182_I	0.504	0.98
110_I	291_T	0.503	0.98
51_I	65_A	0.502	0.98
37_R	40_K	0.502	0.98
272_A	293_I	0.501	0.98
119_A	286_F	0.501	0.98
354_I	357_F	0.501	0.98
407_Q	410_I	0.501	0.98
223_I	226_A	0.500	0.98

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3n6rA	1	0.8396	100	0.302	Contact Map
4rcnA	6	0.9109	100	0.307	Contact Map
3u9tA	3	0.9666	100	0.309	Contact Map
3va7A	1	0.833	100	0.31	Contact Map
4qshA	4	0.8597	100	0.314	Contact Map
2qf7A	4	0.8953	100	0.315	Contact Map
3hblA	4	0.9933	100	0.32	Contact Map
4mv4A	2	0.9777	100	0.321	Contact Map
2vpqA	2	0.9844	100	0.331	Contact Map
2dzdA	2	0.9933	100	0.332	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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