ACRF - ECOLI - GREMLIN Contacts

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ACRF - Multidrug export protein AcrF

UniProt:	P24181	Sequences: MANFFIRRPIFAWVLAIILMMAGALAILQLPVAQYPTIAPPAVSVSANYPGADAQTVQDTVTQVIEQNMNGIDNLMYMSSTSDSAGSVTITLTFQSGTDPDIAQVQVQNKLQLATPLLPQEVQQQGISVEKSSSSYLMVAGFVSDNPGTTQDDISDYVASNVKDTLSRLNGVGDVQLFGAQYAMRIWLDADLLNKYKLTPVDVINQLKVQNDQIAAGQLGGTPALPGQQLNASIIAQTRFKNPEEFGKVTLRVNSDGSVVRLKDVARVELGGENYNVIARINGKPAAGLGIKLATGANALDTAKAIKAKLAELQPFFPQGMKVLYPYDTTPFVQLSIHEVVKTLFEAIMLVFLVMYLFLQNMRATLIPTIAVPVVLLGTFAILAAFGYSINTLTMFGMVLAIGLLVDDAIVVVENVERVMMEDKLPPKEATEKSMSQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIVSAMALSVLVALILTPALCATLLKPVSAEHHENKGGFFGWFNTTFDHSVNHYTNSVGKILGSTGRYLLIYALIVAGMVVLFLRLPSSFLPEEDQGVFLTMIQLPAGATQERTQKVLDQVTDYYLKNEKANVESVFTVNGFSFSGQAQNAGMAFVSLKPWEERNGDENSAEAVIHRAKMELGKIRDGFVIPFNMPAIVELGTATGFDFELIDQAGLGHDALTQARNQLLGMAAQHPASLVSVRPNGLEDTAQFKLEVDQEKAQALGVSLSDINQTISTALGGTYVNDFIDRGRVKKLYVQADAKFRMLPEDVDKLYVRSANGEMVPFSAFTTSHWVYGSPRLERYNGLPSMEIQGEAAPGTSSGDAMALMENLASKLPAGIGYDWTGMSYQERLSGNQAPALVAISFVVVFLCLAALYESWSIPVSVMLVVPLGIVGVLLAATLFNQKNDVYFMVGLLTTIGLSAKNAILIVEFAKDLMEKEGKGVVEATLMAVRMRLRPILMTSLAFILGVLPLAISNGAGSGAQNAVGIGVMGGMVSATLLAIFFVPVFFVVIRRCFKG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10267
Length:	1034 (995)
Sequences:	15789 (10064)
Seq/√Len:	319.1

ECOLI - ACRF ACRD ACRB MDTB MDTF MDTC CUSA
BACSU - SWRC SECDF

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
62_T	88_V	3.976	1.00
958_G	961_E	3.913	1.00
244_E	247_G	3.913	1.00
47_A	88_V	3.838	1.00
309_K	312_E	3.821	1.00
247_G	263_K	3.785	1.00
311_A	314_Q	3.771	1.00
914_A	1008_G	3.577	1.00
708_H	711_S	3.569	1.00
590_L	624_G	3.464	1.00
729_E	807_H	3.429	1.00
529_S	1019_F	3.305	1.00
304_K	334_Q	3.153	1.00
425_L	433_K	3.078	1.00
150_T	153_D	3.071	1.00
585_R	588_K	3.023	1.00
248_K	263_K	3.012	1.00
75_L	92_L	2.986	1.00
3_N	7_R	2.973	1.00
280_R	594_T	2.929	1.00
426_P	429_E	2.924	1.00
188_L	203_V	2.914	1.00
834_T	842_L	2.910	1.00
759_N	770_L	2.898	1.00
730_V	735_A	2.859	1.00
531_G	964_L	2.856	1.00
62_T	82_S	2.841	1.00
193_L	198_L	2.812	1.00
58_Q	822_P	2.801	1.00
735_A	745_I	2.797	1.00
731_D	805_T	2.791	1.00
169_L	305_A	2.743	1.00
142_F	158_V	2.703	1.00
690_G	693_A	2.693	1.00
693_A	696_Q	2.647	1.00
165_T	309_K	2.647	1.00
247_G	268_V	2.644	1.00
262_L	268_V	2.617	1.00
76_M	93_T	2.590	1.00
835_S	838_D	2.586	1.00
896_I	949_K	2.579	1.00
251_L	265_V	2.553	1.00
307_K	328_D	2.541	1.00
282_N	607_S	2.508	1.00
345_F	349_M	2.504	1.00
243_P	247_G	2.454	1.00
154_I	321_M	2.445	1.00
704_M	707_Q	2.445	1.00
741_S	744_D	2.439	1.00
697_A	854_I	2.414	1.00
378_G	480_L	2.402	1.00
189_D	192_L	2.328	1.00
587_Q	591_D	2.313	1.00
314_Q	322_K	2.302	1.00
918_F	1004_I	2.261	1.00
76_M	95_Q	2.256	1.00
186_I	207_L	2.253	1.00
731_D	734_K	2.251	1.00
527_T	968_R	2.238	1.00
157_Y	321_M	2.237	1.00
600_N	604_N	2.231	1.00
246_F	262_L	2.227	1.00
702_L	706_A	2.217	1.00
144_S	148_G	2.193	1.00
632_P	635_E	2.181	1.00
382_I	476_S	2.171	1.00
145_D	322_K	2.169	1.00
573_T	628_V	2.156	1.00
696_Q	700_Q	2.154	1.00
957_K	965_M	2.146	1.00
834_T	838_D	2.143	1.00
419_V	425_L	2.136	1.00
204_I	772_V	2.130	1.00
730_V	745_I	2.124	1.00
188_L	200_P	2.124	1.00
642_S	645_A	2.119	1.00
301_D	305_A	2.115	1.00
182_Y	270_L	2.112	1.00
952_M	1025_F	2.110	1.00
419_V	437_Q	2.082	1.00
65_I	90_I	2.078	1.00
783_E	786_D	2.064	1.00
418_R	422_E	2.031	1.00
65_I	69_M	2.029	1.00
951_L	955_E	2.015	1.00
600_N	649_R	2.013	1.00
714_S	829_E	2.006	1.00
728_L	804_T	2.003	1.00
989_A	1007_M	2.003	1.00
740_V	790_V	1.991	1.00
342_K	346_E	1.989	1.00
597_Y	650_A	1.989	1.00
535_G	960_V	1.976	1.00
712_L	715_V	1.962	1.00
799_P	802_A	1.960	1.00
702_L	717_P	1.956	1.00
599_K	653_E	1.951	1.00
187_W	269_E	1.949	1.00
963_T	1026_V	1.943	1.00
577_L	581_A	1.943	1.00
252_R	255_S	1.940	1.00
686_Q	701_L	1.933	1.00
729_E	805_T	1.932	1.00
415_N	437_Q	1.931	1.00
606_E	631_K	1.927	1.00
951_L	957_K	1.912	1.00
145_D	284_K	1.900	1.00
786_D	801_S	1.898	1.00
280_R	587_Q	1.890	1.00
10_I	888_A	1.882	1.00
371_A	484_V	1.881	1.00
526_Y	967_V	1.877	1.00
727_K	809_V	1.876	1.00
57_V	61_V	1.846	1.00
705_A	843_M	1.843	1.00
532_K	536_S	1.838	1.00
429_E	433_K	1.831	1.00
193_L	265_V	1.814	1.00
708_H	842_L	1.814	1.00
242_N	245_E	1.800	1.00
55_Q	59_D	1.799	1.00
546_L	550_G	1.785	1.00
162_V	313_L	1.776	1.00
190_A	778_F	1.776	1.00
537_T	1026_V	1.774	1.00
69_M	90_I	1.773	1.00
699_N	702_L	1.772	1.00
553_V	556_L	1.770	1.00
781_L	784_D	1.761	1.00
62_T	80_S	1.756	1.00
183_A	771_Y	1.751	1.00
521_H	524_N	1.751	1.00
604_N	638_G	1.748	1.00
143_V	324_L	1.744	1.00
450_S	479_A	1.738	1.00
305_A	308_A	1.732	1.00
149_T	320_G	1.729	1.00
8_R	892_E	1.719	1.00
698_R	824_M	1.717	1.00
951_L	965_M	1.713	1.00
702_L	715_V	1.706	1.00
69_M	92_L	1.704	1.00
181_Q	273_E	1.700	1.00
198_L	202_D	1.697	1.00
267_R	775_D	1.696	1.00
740_V	803_F	1.694	1.00
960_V	1026_V	1.690	1.00
92_L	107_V	1.679	1.00
82_S	88_V	1.679	1.00
590_L	610_T	1.679	1.00
521_H	525_H	1.674	1.00
388_Y	472_I	1.666	1.00
697_A	700_Q	1.665	1.00
244_E	248_K	1.661	1.00
7_R	428_K	1.660	1.00
211_N	759_N	1.654	1.00
204_I	208_K	1.651	1.00
734_K	737_A	1.649	1.00
536_S	539_R	1.649	1.00
592_Q	595_D	1.644	1.00
600_N	653_E	1.641	1.00
651_K	714_S	1.637	1.00
920_Q	1004_I	1.632	1.00
415_N	418_R	1.630	1.00
571_F	628_V	1.624	1.00
597_Y	605_V	1.619	1.00
24_A	28_L	1.616	1.00
596_Y	653_E	1.611	1.00
65_I	114_A	1.610	1.00
241_K	245_E	1.609	1.00
844_E	866_R	1.607	1.00
532_K	535_G	1.601	1.00
29_Q	384_A	1.595	1.00
745_I	803_F	1.583	1.00
527_T	531_G	1.581	1.00
20_M	377_L	1.577	1.00
541_L	545_A	1.576	1.00
141_G	281_I	1.574	1.00
884_F	897_P	1.572	1.00
199_T	202_D	1.568	1.00
903_V	941_A	1.561	1.00
307_K	325_Y	1.555	1.00
649_R	653_E	1.554	1.00
735_A	740_V	1.553	1.00
727_K	807_H	1.547	1.00
207_L	249_V	1.545	1.00
304_K	308_A	1.542	1.00
595_D	599_K	1.539	1.00
240_F	246_F	1.538	1.00
775_D	778_F	1.533	1.00
408_D	939_K	1.527	1.00
3_N	432_E	1.523	1.00
552_V	556_L	1.523	1.00
188_L	193_L	1.521	1.00
47_A	62_T	1.519	1.00
297_A	302_T	1.518	1.00
586_T	624_G	1.516	1.00
301_D	304_K	1.516	1.00
386_F	476_S	1.508	1.00
74_N	98_T	1.507	1.00
841_A	844_E	1.505	1.00
679_F	828_G	1.504	1.00
591_D	595_D	1.501	1.00
338_H	342_K	1.498	1.00
418_R	969_M	1.497	1.00
575_I	590_L	1.494	1.00
479_A	483_L	1.484	1.00
416_V	493_C	1.482	1.00
189_D	267_R	1.482	1.00
248_K	261_R	1.478	1.00
26_A	381_A	1.474	1.00
758_V	772_V	1.471	1.00
78_M	92_L	1.467	1.00
842_L	845_N	1.467	1.00
575_I	593_V	1.466	1.00
638_G	649_R	1.465	1.00
419_V	422_E	1.463	1.00
202_D	791_R	1.460	1.00
472_I	476_S	1.458	1.00
838_D	841_A	1.452	1.00
529_S	532_K	1.451	1.00
577_L	589_V	1.449	1.00
695_T	699_N	1.441	1.00
379_T	477_A	1.440	1.00
328_D	331_P	1.435	1.00
142_F	162_V	1.435	1.00
839_A	842_L	1.434	1.00
192_L	196_Y	1.432	1.00
14_V	885_L	1.430	1.00
711_S	842_L	1.429	1.00
307_K	311_A	1.429	1.00
548_V	552_V	1.420	1.00
43_V	107_V	1.419	1.00
593_V	654_L	1.419	1.00
34_Q	568_Q	1.417	1.00
703_G	707_Q	1.410	1.00
202_D	205_N	1.403	1.00
575_I	624_G	1.402	1.00
700_Q	703_G	1.399	1.00
604_N	646_V	1.398	1.00
47_A	122_V	1.397	1.00
790_V	803_F	1.397	1.00
57_V	82_S	1.397	1.00
728_L	806_S	1.395	1.00
757_Y	769_K	1.391	1.00
61_V	122_V	1.384	1.00
581_A	585_R	1.384	1.00
98_T	103_A	1.382	1.00
172_V	291_I	1.382	1.00
688_G	854_I	1.382	1.00
525_H	528_N	1.381	1.00
339_E	342_K	1.380	1.00
412_V	435_M	1.380	1.00
99_D	102_I	1.380	1.00
693_A	697_A	1.379	1.00
612_N	624_G	1.379	1.00
686_Q	694_L	1.375	1.00
317_F	323_V	1.375	1.00
791_R	797_M	1.373	1.00
199_T	791_R	1.370	1.00
541_L	1027_V	1.369	1.00
205_N	209_V	1.368	1.00
864_Q	867_L	1.362	1.00
605_V	628_V	1.360	1.00
571_F	647_I	1.359	1.00
234_I	753_L	1.359	1.00
201_V	205_N	1.356	1.00
841_A	845_N	1.356	1.00
844_E	847_A	1.354	1.00
250_T	259_V	1.354	1.00
66_E	817_R	1.350	1.00
553_V	557_R	1.350	1.00
600_N	646_V	1.346	1.00
591_D	594_T	1.344	1.00
537_T	1030_R	1.344	1.00
740_V	793_A	1.339	1.00
712_L	839_A	1.334	1.00
596_Y	600_N	1.334	1.00
648_H	652_M	1.333	1.00
594_T	598_L	1.333	1.00
838_D	842_L	1.326	1.00
571_F	650_A	1.324	1.00
960_V	964_L	1.324	1.00
261_R	264_D	1.323	1.00
47_A	65_I	1.322	1.00
163_K	167_S	1.322	1.00
45_V	92_L	1.322	1.00
792_S	796_E	1.318	1.00
982_I	1007_M	1.318	1.00
352_F	369_T	1.318	1.00
422_E	425_L	1.318	1.00
595_D	598_L	1.317	1.00
205_N	208_K	1.317	1.00
542_L	546_L	1.316	1.00
937_S	1013_A	1.316	1.00
240_F	249_V	1.316	1.00
950_D	954_K	1.315	1.00
349_M	353_L	1.311	1.00
382_I	386_F	1.310	1.00
170_N	305_A	1.310	1.00
700_Q	704_M	1.307	1.00
279_A	288_G	1.306	1.00
192_L	195_K	1.305	1.00
698_R	717_P	1.305	1.00
53_D	56_T	1.304	1.00
245_E	248_K	1.299	1.00
45_V	69_M	1.298	1.00
631_K	635_E	1.296	1.00
596_Y	656_K	1.293	1.00
952_M	1029_R	1.292	1.00
598_L	608_V	1.291	1.00
425_L	429_E	1.289	1.00
560_S	837_G	1.287	1.00
604_N	631_K	1.286	1.00
712_L	828_G	1.285	1.00
58_Q	817_R	1.280	1.00
4_F	11_F	1.279	1.00
203_V	265_V	1.276	1.00
115_T	124_Q	1.275	1.00
69_M	107_V	1.275	1.00
209_V	736_Q	1.274	1.00
77_Y	819_N	1.267	1.00
22_A	381_A	1.267	1.00
6_I	491_A	1.266	1.00
833_G	838_D	1.265	1.00
202_D	252_R	1.264	1.00
77_Y	93_T	1.263	1.00
550_G	554_L	1.262	1.00
278_I	587_Q	1.261	1.00
959_V	963_T	1.260	1.00
19_L	378_G	1.259	1.00
305_A	309_K	1.258	1.00
374_V	488_L	1.256	1.00
525_H	529_S	1.255	1.00
911_V	930_L	1.254	1.00
143_V	322_K	1.253	1.00
527_T	965_M	1.250	1.00
193_L	203_V	1.249	1.00
63_Q	817_R	1.245	1.00
415_N	947_F	1.244	1.00
69_M	78_M	1.244	1.00
112_Q	115_T	1.243	1.00
982_I	1011_V	1.239	1.00
43_V	104_Q	1.238	1.00
915_A	926_F	1.234	1.00
27_I	341_V	1.230	1.00
588_K	592_Q	1.229	1.00
13_W	894_W	1.217	1.00
577_L	586_T	1.216	1.00
703_G	706_A	1.213	1.00
948_A	963_T	1.212	1.00
142_F	323_V	1.211	1.00
701_L	846_L	1.211	1.00
689_L	854_I	1.208	1.00
961_E	965_M	1.207	1.00
949_K	954_K	1.204	1.00
608_V	626_A	1.204	1.00
58_Q	815_L	1.200	1.00
542_L	549_A	1.199	1.00
156_D	768_K	1.196	1.00
653_E	656_K	1.196	1.00
309_K	313_L	1.191	1.00
549_A	553_V	1.188	1.00
6_I	432_E	1.185	1.00
952_M	959_V	1.181	1.00
725_Q	811_G	1.180	1.00
561_S	921_K	1.180	1.00
685_D	818_Y	1.178	1.00
65_I	111_L	1.178	1.00
247_G	267_R	1.177	1.00
834_T	839_A	1.176	1.00
310_L	323_V	1.176	1.00
26_A	384_A	1.173	1.00
149_T	153_D	1.173	1.00
140_A	325_Y	1.173	1.00
216_A	236_A	1.172	1.00
986_L	1007_M	1.171	1.00
906_L	1016_L	1.168	1.00
339_E	999_Q	1.165	1.00
957_K	961_E	1.164	1.00
68_N	114_A	1.163	1.00
304_K	307_K	1.162	1.00
3_N	436_S	1.160	1.00
57_V	88_V	1.160	1.00
75_L	78_M	1.160	1.00
165_T	316_F	1.158	1.00
784_D	787_K	1.158	1.00
74_N	95_Q	1.157	1.00
687_A	823_S	1.156	1.00
449_L	939_K	1.153	1.00
975_L	979_L	1.152	1.00
528_N	531_G	1.150	1.00
530_V	534_L	1.149	1.00
648_H	651_K	1.148	1.00
533_I	1023_V	1.148	1.00
419_V	433_K	1.147	1.00
187_W	267_R	1.145	1.00
218_Q	231_N	1.145	1.00
590_L	612_N	1.144	1.00
110_K	113_L	1.143	1.00
839_A	843_M	1.141	1.00
527_T	964_L	1.138	1.00
172_V	302_T	1.137	1.00
166_L	175_V	1.136	1.00
157_Y	161_N	1.131	1.00
49_Y	52_A	1.130	1.00
433_K	436_S	1.128	1.00
262_L	266_A	1.128	1.00
206_Q	249_V	1.128	1.00
379_T	476_S	1.125	1.00
834_T	843_M	1.125	1.00
923_D	926_F	1.122	1.00
835_S	839_A	1.121	1.00
859_T	863_Y	1.120	1.00
308_A	312_E	1.119	1.00
701_L	826_I	1.118	1.00
250_T	261_R	1.115	1.00
920_Q	1000_N	1.113	1.00
303_A	330_T	1.112	1.00
20_M	24_A	1.112	1.00
589_V	592_Q	1.111	1.00
370_I	492_L	1.110	1.00
835_S	842_L	1.110	1.00
76_M	867_L	1.110	1.00
45_V	65_I	1.109	1.00
705_A	712_L	1.107	1.00
298_N	301_D	1.107	1.00
818_Y	859_T	1.106	1.00
949_K	952_M	1.103	1.00
311_A	315_P	1.100	1.00
711_S	834_T	1.098	1.00
693_A	854_I	1.096	1.00
16_A	488_L	1.095	1.00
446_A	482_V	1.095	1.00
149_T	321_M	1.094	1.00
165_T	313_L	1.093	1.00
688_G	693_A	1.093	1.00
388_Y	394_T	1.091	1.00
196_Y	260_V	1.090	1.00
145_D	148_G	1.089	1.00
5_F	12_A	1.088	1.00
138_M	306_I	1.087	1.00
140_A	323_V	1.086	1.00
971_L	975_L	1.085	1.00
870_N	873_P	1.084	1.00
773_Q	779_R	1.081	1.00
445_I	482_V	1.080	1.00
11_F	889_A	1.079	1.00
528_N	532_K	1.078	1.00
947_F	951_L	1.076	1.00
524_N	528_N	1.076	1.00
760_D	769_K	1.076	1.00
821_L	855_G	1.076	1.00
533_I	540_Y	1.075	1.00
544_Y	1020_F	1.074	1.00
248_K	733_E	1.072	1.00
592_Q	596_Y	1.071	1.00
597_Y	626_A	1.071	1.00
594_T	610_T	1.071	1.00
415_N	419_V	1.069	1.00
955_E	965_M	1.069	1.00
557_R	916_T	1.067	1.00
732_Q	742_L	1.067	1.00
142_F	154_I	1.065	1.00
78_M	820_G	1.064	1.00
493_C	497_L	1.064	1.00
66_E	80_S	1.062	1.00
175_V	289_L	1.062	1.00
138_M	307_K	1.061	1.00
447_M	886_C	1.060	1.00
708_H	845_N	1.059	1.00
561_S	923_D	1.059	1.00
965_M	968_R	1.058	1.00
891_Y	942_I	1.058	1.00
686_Q	697_A	1.058	1.00
539_R	542_L	1.054	1.00
533_I	1019_F	1.052	1.00
699_N	703_G	1.051	1.00
186_I	758_V	1.049	1.00
155_S	180_A	1.047	1.00
979_L	983_L	1.043	1.00
115_T	123_Q	1.043	1.00
834_T	840_M	1.042	1.00
978_S	1014_T	1.042	1.00
833_G	842_L	1.041	1.00
371_A	489_T	1.037	1.00
792_S	795_G	1.037	1.00
706_A	715_V	1.035	1.00
79_S	93_T	1.034	1.00
750_S	756_T	1.034	1.00
251_L	260_V	1.033	1.00
141_G	286_A	1.032	1.00
81_T	91_T	1.032	1.00
697_A	850_L	1.031	1.00
371_A	409_A	1.031	1.00
185_R	773_Q	1.030	1.00
235_I	725_Q	1.029	1.00
98_T	106_Q	1.028	1.00
982_I	1010_M	1.028	1.00
417_E	421_M	1.025	1.00
308_A	311_A	1.025	1.00
743_S	747_Q	1.025	1.00
314_Q	323_V	1.025	1.00
789_Y	797_M	1.023	1.00
520_D	524_N	1.023	1.00
535_G	538_G	1.022	1.00
785_V	806_S	1.022	1.00
606_E	629_S	1.021	1.00
835_S	843_M	1.021	1.00
30_L	380_F	1.018	1.00
592_Q	657_I	1.017	1.00
444_G	886_C	1.017	1.00
80_S	817_R	1.017	1.00
334_Q	338_H	1.016	1.00
644_E	648_H	1.016	1.00
143_V	284_K	1.015	1.00
68_N	113_L	1.015	1.00
428_K	432_E	1.015	1.00
415_N	438_I	1.014	1.00
108_Q	112_Q	1.014	1.00
145_D	320_G	1.013	1.00
367_I	492_L	1.010	1.00
914_A	1004_I	1.009	1.00
863_Y	867_L	1.009	1.00
187_W	775_D	1.008	1.00
312_E	315_P	1.007	1.00
201_V	744_D	1.006	1.00
261_R	733_E	1.006	1.00
545_A	549_A	1.004	1.00
830_A	839_A	1.004	1.00
836_S	839_A	1.004	1.00
596_Y	599_K	1.003	1.00
711_S	831_A	1.002	1.00
978_S	982_I	1.002	1.00
427_P	431_T	1.002	1.00
382_I	480_L	0.999	1.00
246_F	268_V	0.998	1.00
163_K	175_V	0.998	1.00
597_Y	628_V	0.998	1.00
444_G	890_L	0.996	1.00
549_A	552_V	0.995	1.00
740_V	745_I	0.995	1.00
46_S	87_S	0.993	1.00
216_A	749_I	0.992	1.00
751_T	756_T	0.992	1.00
702_L	826_I	0.992	1.00
45_V	90_I	0.991	1.00
833_G	836_S	0.991	1.00
833_G	843_M	0.990	1.00
303_A	307_K	0.987	1.00
950_D	955_E	0.986	1.00
370_I	488_L	0.986	1.00
947_F	969_M	0.985	1.00
565_E	644_E	0.982	1.00
538_G	542_L	0.981	1.00
787_K	801_S	0.980	1.00
692_D	695_T	0.980	1.00
183_A	273_E	0.980	1.00
144_S	149_T	0.980	1.00
20_M	374_V	0.978	1.00
554_L	913_L	0.977	1.00
538_G	1027_V	0.976	1.00
214_I	746_N	0.975	1.00
449_L	478_M	0.974	1.00
913_L	917_L	0.973	1.00
537_T	1027_V	0.972	1.00
420_M	427_P	0.972	1.00
207_L	758_V	0.972	1.00
645_A	649_R	0.971	1.00
582_T	585_R	0.970	1.00
281_I	286_A	0.967	1.00
307_K	330_T	0.967	1.00
102_I	106_Q	0.964	1.00
948_A	1025_F	0.963	1.00
429_E	432_E	0.962	1.00
280_R	591_D	0.962	1.00
726_F	782_P	0.962	1.00
94_F	107_V	0.958	1.00
687_A	857_D	0.956	1.00
193_L	196_Y	0.953	1.00
148_G	320_G	0.949	1.00
911_V	1005_G	0.949	1.00
588_K	591_D	0.949	1.00
207_L	246_F	0.949	1.00
761_F	770_L	0.948	1.00
48_N	87_S	0.948	1.00
439_Q	443_V	0.943	1.00
437_Q	950_D	0.943	1.00
600_N	650_A	0.942	1.00
360_Q	516_N	0.942	1.00
643_A	647_I	0.941	1.00
899_S	1024_F	0.941	1.00
846_L	856_Y	0.940	1.00
70_N	820_G	0.939	1.00
965_M	969_M	0.938	1.00
231_N	276_N	0.938	1.00
144_S	320_G	0.938	1.00
80_S	90_I	0.937	1.00
836_S	840_M	0.937	1.00
515_F	519_F	0.935	1.00
247_G	266_A	0.935	1.00
983_L	986_L	0.934	1.00
543_I	550_G	0.933	1.00
189_D	778_F	0.933	1.00
518_T	521_H	0.932	1.00
451_A	882_V	0.930	1.00
383_L	388_Y	0.930	1.00
341_V	345_F	0.927	1.00
593_V	626_A	0.925	1.00
757_Y	771_Y	0.922	1.00
138_M	303_A	0.921	1.00
845_N	848_S	0.919	1.00
394_T	469_Q	0.918	1.00
517_T	521_H	0.917	1.00
708_H	846_L	0.913	1.00
546_L	549_A	0.913	1.00
246_F	770_L	0.910	1.00
186_I	266_A	0.909	1.00
551_M	912_L	0.909	1.00
198_L	251_L	0.908	1.00
178_F	290_G	0.908	1.00
833_G	840_M	0.908	1.00
198_L	203_V	0.907	1.00
571_F	630_L	0.907	1.00
573_T	597_Y	0.906	1.00
13_W	17_I	0.906	1.00
594_T	608_V	0.906	1.00
534_L	1026_V	0.905	1.00
815_L	822_P	0.904	1.00
760_D	767_V	0.900	1.00
652_M	655_G	0.900	1.00
307_K	314_Q	0.899	1.00
540_Y	543_I	0.898	1.00
786_D	806_S	0.898	1.00
203_V	772_V	0.898	1.00
909_V	1012_S	0.897	1.00
283_G	594_T	0.897	1.00
698_R	702_L	0.897	1.00
438_I	446_A	0.895	1.00
718_N	816_E	0.894	1.00
424_K	430_A	0.893	1.00
838_D	843_M	0.892	1.00
431_T	494_A	0.891	1.00
83_D	87_S	0.890	1.00
833_G	839_A	0.889	1.00
604_N	637_N	0.889	1.00
735_A	803_F	0.888	1.00
448_V	939_K	0.888	1.00
638_G	646_V	0.887	1.00
523_V	527_T	0.886	1.00
68_N	117_L	0.886	1.00
185_R	269_E	0.885	1.00
914_A	918_F	0.885	1.00
169_L	309_K	0.884	1.00
416_V	434_S	0.884	1.00
526_Y	530_V	0.884	1.00
526_Y	534_L	0.881	1.00
645_A	648_H	0.879	1.00
432_E	436_S	0.879	1.00
460_G	871_Q	0.879	1.00
374_V	484_V	0.879	1.00
650_A	654_L	0.878	1.00
362_M	366_L	0.878	1.00
581_A	586_T	0.878	1.00
16_A	374_V	0.877	1.00
163_K	177_L	0.877	1.00
686_Q	854_I	0.876	1.00
963_T	967_V	0.876	1.00
906_L	1020_F	0.874	1.00
47_A	82_S	0.873	1.00
547_I	909_V	0.873	1.00
310_L	314_Q	0.871	1.00
302_T	305_A	0.870	1.00
243_P	270_L	0.869	1.00
744_D	747_Q	0.868	1.00
646_V	649_R	0.867	1.00
651_K	655_G	0.867	1.00
964_L	968_R	0.867	1.00
7_R	432_E	0.867	1.00
62_T	90_I	0.866	1.00
686_Q	826_I	0.865	1.00
840_M	843_M	0.865	1.00
166_L	309_K	0.864	1.00
156_D	160_S	0.864	1.00
780_M	784_D	0.864	1.00
412_V	442_L	0.864	1.00
441_A	950_D	0.861	1.00
986_L	990_I	0.860	1.00
518_T	522_S	0.860	1.00
898_V	902_L	0.860	1.00
190_A	774_A	0.859	1.00
948_A	966_A	0.859	1.00
694_L	854_I	0.856	1.00
649_R	652_M	0.855	1.00
71_G	110_K	0.855	1.00
174_D	292_K	0.853	1.00
728_L	749_I	0.853	1.00
596_Y	657_I	0.852	1.00
58_Q	62_T	0.852	1.00
836_S	842_L	0.851	1.00
693_A	853_G	0.850	1.00
347_A	351_V	0.848	1.00
252_R	260_V	0.847	1.00
1017_A	1021_V	0.846	1.00
4_F	8_R	0.846	1.00
404_L	408_D	0.845	1.00
840_M	862_S	0.844	1.00
712_L	843_M	0.844	1.00
880_F	901_M	0.843	1.00
313_L	317_F	0.843	1.00
550_G	553_V	0.843	1.00
519_F	523_V	0.839	1.00
422_E	433_K	0.839	1.00
158_V	289_L	0.839	1.00
397_G	401_A	0.838	1.00
44_S	91_T	0.837	1.00
682_E	823_S	0.836	1.00
726_F	808_W	0.834	1.00
404_L	980_A	0.834	1.00
610_T	626_A	0.833	1.00
404_L	981_F	0.833	1.00
152_D	272_G	0.832	1.00
940_N	1013_A	0.830	1.00
755_G	773_Q	0.830	1.00
273_E	769_K	0.829	1.00
139_V	290_G	0.828	1.00
705_A	715_V	0.828	1.00
531_G	961_E	0.827	1.00
745_I	800_F	0.824	1.00
959_V	1026_V	0.823	1.00
47_A	125_Q	0.823	1.00
534_L	1023_V	0.822	1.00
873_P	877_A	0.822	1.00
48_N	123_Q	0.821	1.00
652_M	656_K	0.820	1.00
534_L	964_L	0.819	1.00
738_L	798_V	0.818	1.00
593_V	596_Y	0.817	1.00
1024_F	1028_I	0.817	1.00
346_E	349_M	0.816	1.00
752_A	788_L	0.816	1.00
102_I	105_V	0.814	1.00
843_M	858_W	0.814	1.00
137_L	303_A	0.814	1.00
153_D	156_D	0.813	1.00
589_V	657_I	0.813	1.00
188_L	266_A	0.812	1.00
923_D	1001_A	0.812	1.00
939_K	980_A	0.812	1.00
49_Y	57_V	0.811	1.00
209_V	741_S	0.810	1.00
204_I	751_T	0.810	1.00
338_H	341_V	0.810	1.00
840_M	844_E	0.809	1.00
201_V	747_Q	0.808	1.00
358_F	976_M	0.808	1.00
877_A	881_V	0.808	1.00
203_V	206_Q	0.807	1.00
439_Q	486_L	0.806	1.00
1014_T	1017_A	0.806	1.00
46_S	89_T	0.806	1.00
884_F	894_W	0.804	1.00
715_V	828_G	0.803	1.00
541_L	1023_V	0.802	1.00
449_L	981_F	0.800	1.00
155_S	159_A	0.800	1.00
584_E	588_K	0.800	1.00
413_V	493_C	0.799	1.00
278_I	583_Q	0.799	1.00
13_W	495_T	0.799	1.00
638_G	645_A	0.797	1.00
1011_V	1015_L	0.797	1.00
607_S	629_S	0.797	1.00
281_I	607_S	0.797	1.00
740_V	792_S	0.793	1.00
558_L	912_L	0.793	1.00
782_P	786_D	0.792	1.00
604_N	649_R	0.792	1.00
488_L	492_L	0.792	1.00
120_Q	124_Q	0.792	1.00
520_D	523_V	0.791	1.00
184_M	761_F	0.791	1.00
835_S	840_M	0.790	1.00
719_G	824_M	0.789	1.00
81_T	814_R	0.788	1.00
819_N	857_D	0.788	1.00
167_S	174_D	0.786	1.00
695_T	824_M	0.786	1.00
188_L	772_V	0.785	1.00
317_F	321_M	0.784	1.00
240_F	761_F	0.784	1.00
445_I	980_A	0.782	1.00
940_N	978_S	0.781	1.00
2_A	435_M	0.780	1.00
94_F	103_A	0.780	1.00
10_I	894_W	0.780	1.00
700_Q	849_K	0.779	1.00
270_L	763_D	0.778	1.00
918_F	1008_G	0.777	1.00
278_I	612_N	0.777	1.00
752_A	774_A	0.776	1.00
575_I	663_I	0.776	1.00
465_A	468_R	0.776	1.00
381_A	385_A	0.775	1.00
956_G	962_A	0.775	1.00
250_T	253_V	0.775	1.00
52_A	57_V	0.775	1.00
140_A	289_L	0.774	1.00
200_P	751_T	0.773	1.00
246_F	249_V	0.773	1.00
77_Y	818_Y	0.773	1.00
692_D	696_Q	0.772	1.00
555_F	912_L	0.771	1.00
361_N	364_A	0.770	1.00
922_N	927_M	0.770	1.00
50_P	123_Q	0.770	1.00
851_P	854_I	0.770	1.00
186_I	772_V	0.769	1.00
587_Q	612_N	0.769	1.00
383_L	473_T	0.768	0.99
203_V	262_L	0.767	0.99
1012_S	1016_L	0.767	0.99
944_I	967_V	0.767	0.99
571_F	643_A	0.766	0.99
726_F	806_S	0.766	0.99
253_V	259_V	0.765	0.99
457_A	475_V	0.764	0.99
231_N	621_Q	0.764	0.99
118_L	122_V	0.764	0.99
694_L	824_M	0.763	0.99
69_M	111_L	0.763	0.99
523_V	968_R	0.763	0.99
748_T	790_V	0.762	0.99
842_L	846_L	0.761	0.99
628_V	650_A	0.760	0.99
169_L	302_T	0.760	0.99
445_I	939_K	0.759	0.99
450_S	475_V	0.759	0.99
1026_V	1030_R	0.758	0.99
750_S	754_G	0.758	0.99
532_K	537_T	0.757	0.99
713_V	831_A	0.756	0.99
74_N	97_G	0.756	0.99
232_A	726_F	0.756	0.99
177_L	180_A	0.754	0.99
280_R	610_T	0.754	0.99
817_R	822_P	0.753	0.99
850_L	856_Y	0.753	0.99
379_T	480_L	0.753	0.99
687_A	855_G	0.752	0.99
580_G	724_A	0.752	0.99
915_A	1005_G	0.752	0.99
544_Y	548_V	0.752	0.99
534_L	963_T	0.751	0.99
279_A	286_A	0.750	0.99
204_I	756_T	0.750	0.99
734_K	802_A	0.749	0.99
862_S	866_R	0.748	0.99
138_M	310_L	0.747	0.99
876_V	927_M	0.747	0.99
252_R	259_V	0.747	0.99
159_A	163_K	0.746	0.99
697_A	701_L	0.746	0.99
704_M	848_S	0.744	0.99
660_G	664_P	0.743	0.99
959_V	1030_R	0.743	0.99
191_D	787_K	0.740	0.99
836_S	843_M	0.740	0.99
141_G	326_P	0.739	0.99
288_G	609_F	0.739	0.99
25_L	29_Q	0.739	0.99
556_L	559_P	0.739	0.99
573_T	665_F	0.739	0.99
64_V	114_A	0.738	0.99
95_Q	98_T	0.737	0.99
47_A	57_V	0.737	0.99
940_N	1017_A	0.735	0.99
6_I	431_T	0.735	0.99
533_I	536_S	0.735	0.99
138_M	325_Y	0.735	0.99
899_S	1021_V	0.734	0.99
718_N	823_S	0.734	0.99
896_I	899_S	0.734	0.99
37_T	296_G	0.734	0.99
573_T	626_A	0.733	0.99
630_L	646_V	0.732	0.99
391_N	394_T	0.732	0.99
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186_I	265_V	0.540	0.95
538_G	545_A	0.540	0.95
586_T	612_N	0.539	0.95
537_T	1023_V	0.539	0.95
238_T	742_L	0.539	0.95
728_L	745_I	0.539	0.95
528_N	535_G	0.538	0.95
946_E	950_D	0.538	0.95
166_L	306_I	0.538	0.95
978_S	981_F	0.537	0.95
330_T	334_Q	0.537	0.95
360_Q	397_G	0.537	0.95
704_M	849_K	0.537	0.95
446_A	485_A	0.537	0.95
730_V	742_L	0.536	0.95
783_E	787_K	0.536	0.95
442_L	486_L	0.536	0.95
149_T	157_Y	0.536	0.95
171_G	302_T	0.535	0.95
191_D	778_F	0.535	0.95
883_V	934_I	0.535	0.95
210_Q	240_F	0.535	0.95
534_L	960_V	0.534	0.95
136_Y	139_V	0.534	0.95
355_M	406_V	0.534	0.95
144_S	321_M	0.534	0.95
13_W	492_L	0.534	0.95
336_S	392_T	0.534	0.95
177_L	287_A	0.533	0.95
281_I	609_F	0.533	0.95
396_F	999_Q	0.533	0.95
939_K	978_S	0.532	0.95
157_Y	162_V	0.532	0.95
12_A	491_A	0.532	0.95
140_A	310_L	0.532	0.95
207_L	770_L	0.532	0.95
685_D	859_T	0.531	0.94
989_A	992_N	0.531	0.94
724_A	808_W	0.531	0.94
791_R	796_E	0.531	0.94
364_A	417_E	0.530	0.94
836_S	865_E	0.529	0.94
52_A	82_S	0.529	0.94
209_V	744_D	0.529	0.94
16_A	484_V	0.529	0.94
165_T	821_L	0.529	0.94
49_Y	121_E	0.528	0.94
482_V	486_L	0.527	0.94
32_V	390_I	0.527	0.94
728_L	800_F	0.527	0.94
574_M	623_A	0.526	0.94
169_L	172_V	0.526	0.94
58_Q	82_S	0.526	0.94
717_P	826_I	0.525	0.94
16_A	487_I	0.525	0.94
777_K	780_M	0.525	0.94
573_T	593_V	0.525	0.94
880_F	934_I	0.525	0.94
10_I	13_W	0.524	0.94
884_F	901_M	0.524	0.94
952_M	958_G	0.523	0.94
943_L	948_A	0.523	0.94
786_D	805_T	0.523	0.94
376_L	398_M	0.522	0.94
216_A	746_N	0.522	0.94
888_A	892_E	0.521	0.94
747_Q	751_T	0.521	0.94
393_L	399_V	0.521	0.94
717_P	824_M	0.520	0.94
457_A	471_S	0.520	0.94
120_Q	123_Q	0.519	0.94
2_A	6_I	0.519	0.94
926_F	1001_A	0.518	0.94
213_Q	239_R	0.518	0.94
196_Y	265_V	0.518	0.94
652_M	707_Q	0.517	0.94
970_R	977_T	0.517	0.94
740_V	744_D	0.517	0.94
885_L	889_A	0.517	0.94
593_V	661_F	0.516	0.94
967_V	971_L	0.516	0.94
166_L	169_L	0.516	0.94
408_D	445_I	0.516	0.94
367_I	488_L	0.515	0.94
442_L	445_I	0.515	0.94
744_D	791_R	0.515	0.94
412_V	486_L	0.515	0.94
837_G	841_A	0.515	0.94
282_N	324_L	0.514	0.93
252_R	258_S	0.513	0.93
420_M	426_P	0.512	0.93
410_I	976_M	0.512	0.93
900_V	944_I	0.512	0.93
857_D	863_Y	0.512	0.93
353_L	357_L	0.511	0.93
944_I	1017_A	0.511	0.93
525_H	532_K	0.511	0.93
16_A	19_L	0.511	0.93
271_G	275_Y	0.511	0.93
19_L	484_V	0.511	0.93
756_T	772_V	0.511	0.93
255_S	258_S	0.510	0.93
139_V	178_F	0.509	0.93
918_F	989_A	0.509	0.93
915_A	921_K	0.509	0.93
48_N	86_G	0.508	0.93
21_M	25_L	0.508	0.93
140_A	307_K	0.508	0.93
434_S	442_L	0.508	0.93
342_K	345_F	0.507	0.93
366_L	496_L	0.507	0.93
884_F	895_S	0.507	0.93
522_S	525_H	0.507	0.93
914_A	1012_S	0.507	0.93
872_A	927_M	0.506	0.93
904_V	938_A	0.506	0.93
651_K	664_P	0.506	0.93
105_V	108_Q	0.506	0.93
33_A	299_A	0.506	0.93
633_W	636_R	0.506	0.93
696_Q	699_N	0.506	0.93
936_L	981_F	0.505	0.93
187_W	271_G	0.505	0.93
566_E	998_A	0.504	0.93
169_L	306_I	0.504	0.93
529_S	533_I	0.504	0.93
725_Q	809_V	0.503	0.93
9_P	494_A	0.503	0.93
343_T	981_F	0.503	0.93
411_V	442_L	0.503	0.93
136_Y	292_K	0.503	0.93
343_T	984_G	0.502	0.93
697_A	856_Y	0.502	0.93
909_V	913_L	0.501	0.93
597_Y	604_N	0.501	0.93
991_S	1000_N	0.501	0.93
868_S	872_A	0.500	0.93
401_A	404_L	0.500	0.93
711_S	838_D	0.500	0.93

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4k0jA	3	0.9294	100	0.228	Contact Map
4mt1A	3	0.971	100	0.285	Contact Map
3w9iA	3	0.9932	100	0.294	Contact Map
3ne5A	3	0.9632	100	0.297	Contact Map
4dx5A	3	0.9913	100	0.308	Contact Map
3aqpA	1	0.6712	100	0.739	Contact Map
4r86A	1	0.2805	100	0.749	Contact Map
2ew9A	1	0.1431	88	0.98	Contact Map
4n8nA	1	0.0967	82.8	0.982	Contact Map
4u9rA	1	0.1335	65.1	0.984	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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