GREMLIN Database
YFFB - Protein YffB
UniProt: P24178 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11147
Length: 118 (111)
Sequences: 2497 (1744)
Seq/√Len: 165.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
21_E27_Y3.1471.00
39_S81_A2.5581.00
46_I80_A2.4561.00
66_D69_T2.4001.00
33_R88_A2.2691.00
4_L17_R2.1951.00
6_G29_F2.1821.00
95_L111_Y2.1131.00
97_V101_P2.0921.00
67_E70_R1.9951.00
39_S43_N1.9591.00
8_K31_D1.9451.00
43_N80_A1.8021.00
31_D34_V1.7591.00
61_T86_M1.5991.00
60_T64_K1.5711.00
38_D41_L1.5481.00
3_T28_R1.4921.00
19_W106_F1.4821.00
44_D48_E1.4571.00
107_S110_S1.4001.00
42_L84_T1.3951.00
61_T65_L1.3921.00
47_N76_A1.3811.00
75_D78_S1.3801.00
59_G88_A1.3501.00
46_I50_G1.3461.00
52_E57_T1.3351.00
96_C102_M1.3331.00
13_I32_Y1.3331.00
5_Y30_H1.3181.00
49_L54_L1.3021.00
60_T63_R1.2901.00
19_W23_N1.2861.00
30_H36_G1.2731.00
17_R29_F1.2651.00
8_K34_V1.2631.00
4_L13_I1.2471.00
17_R21_E1.2431.00
46_I54_L1.2371.00
53_A58_R1.2231.00
55_L83_M1.2031.00
41_L96_C1.2001.00
53_A104_L1.1881.00
73_I78_S1.1811.00
96_C99_G1.1761.00
109_S112_Q1.1761.00
6_G17_R1.1341.00
30_H41_L1.1261.00
83_M89_I1.1121.00
9_N14_K1.1101.00
41_L44_D1.1091.00
8_K17_R1.0981.00
103_L114_F1.0951.00
67_E71_N1.0911.00
41_L45_F1.0861.00
13_I17_R1.0841.00
51_W79_A1.0761.00
58_R107_S1.0751.00
71_N79_A1.0730.99
49_L104_L1.0610.99
39_S80_A1.0570.99
103_L115_F1.0500.99
48_E102_M1.0450.99
61_T64_K1.0240.99
76_A80_A1.0160.99
110_S113_Q1.0150.99
7_I13_I1.0140.99
46_I51_W1.0010.99
36_G90_I0.9980.99
72_K78_S0.9880.99
49_L102_M0.9610.99
28_R35_D0.9520.99
45_F94_L0.9510.99
19_W112_Q0.9500.99
108_D112_Q0.9400.99
83_M90_I0.9250.99
43_N47_N0.9170.98
110_S114_F0.9070.98
4_L95_L0.9030.98
69_T85_E0.9000.98
3_T30_H0.8940.98
39_S77_A0.8850.98
18_R22_A0.8840.98
13_I89_I0.8680.98
95_L115_F0.8650.98
43_N76_A0.8610.98
111_Y115_F0.8520.97
42_L80_A0.8450.97
109_S113_Q0.8450.97
94_L104_L0.8450.97
101_P114_F0.8380.97
62_W89_I0.8330.97
103_L111_Y0.8160.97
16_A20_L0.8130.97
45_F102_M0.8130.97
44_D96_C0.8100.97
46_I76_A0.8100.97
23_N112_Q0.7970.96
54_L104_L0.7810.96
30_H35_D0.7760.96
34_V59_G0.7570.95
43_N77_A0.7390.94
76_A79_A0.7330.94
14_K18_R0.7310.94
81_A85_E0.7310.94
97_V100_K0.7280.94
40_E43_N0.7250.94
62_W73_I0.7190.93
21_E26_D0.7160.93
7_I88_A0.7060.93
33_R61_T0.6990.92
11_D18_R0.6900.92
62_W70_R0.6850.92
32_Y90_I0.6840.92
95_L103_L0.6830.92
18_R21_E0.6820.91
30_H37_L0.6800.91
59_G64_K0.6730.91
17_R27_Y0.6680.91
32_Y94_L0.6660.90
6_G31_D0.6640.90
11_D14_K0.6630.90
39_S84_T0.6570.90
65_L82_L0.6470.89
48_E100_K0.6400.89
54_L94_L0.6390.89
4_L29_F0.6360.88
71_N82_L0.6340.88
37_L41_L0.6300.88
94_L101_P0.6220.87
55_L79_A0.6210.87
51_W76_A0.6150.87
79_A83_M0.6120.86
8_K13_I0.6070.86
4_L20_L0.6030.86
52_E79_A0.5940.85
61_T88_A0.5930.85
55_L87_P0.5900.84
9_N31_D0.5810.83
64_K86_M0.5740.83
14_K17_R0.5640.82
45_F96_C0.5590.81
50_G53_A0.5530.80
5_Y36_G0.5520.80
7_I33_R0.5510.80
79_A82_L0.5490.80
37_L84_T0.5490.80
19_W108_D0.5390.79
8_K88_A0.5370.78
33_R59_G0.5330.78
32_Y37_L0.5330.78
5_Y41_L0.5330.78
96_C100_K0.5310.78
103_L107_S0.5210.76
48_E101_P0.5210.76
48_E97_V0.5110.75
56_N63_R0.5090.75
59_G87_P0.5080.75
42_L90_I0.5050.74
44_D47_N0.5050.74
16_A111_Y0.5040.74
11_D58_R0.5020.74
12_T59_G0.5010.74
103_L110_S0.5010.74
19_W79_A0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fz4A 1 0.9661 100 0.282 Contact Map
3gkxA 2 0.9661 100 0.293 Contact Map
1rw1A 1 0.9661 100 0.298 Contact Map
2kokA 1 0.9746 100 0.3 Contact Map
3f0iA 1 0.9492 100 0.318 Contact Map
1s3cA 2 0.9746 100 0.32 Contact Map
2m46A 1 0.9746 100 0.321 Contact Map
2mu0A 1 0.9492 100 0.326 Contact Map
1z3eA 1 0.9746 100 0.328 Contact Map
3l78A 1 0.9746 100 0.334 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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