ACRD - ECOLI - GREMLIN Contacts

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ACRD - Probable aminoglycoside efflux pump

UniProt:	P24177	Sequences: MANFFIDRPIFAWVLAILLCLTGTLAIFSLPVEQYPDLAPPNVRVTANYPGASAQTLENTVTQVIEQNMTGLDNLMYMSSQSSGTGQASVTLSFKAGTDPDEAVQQVQNQLQSAMRKLPQAVQNQGVTVRKTGDTNILTIAFVSTDGSMDKQDIADYVASNIQDPLSRVNGVGDIDAYGSQYSMRIWLDPAKLNSFQMTAKDVTDAIESQNAQIAVGQLGGTPSVDKQALNATINAQSLLQTPEQFRDITLRVNQDGSEVRLGDVATVEMGAEKYDYLSRFNGKPASGLGVKLASGANEMATAELVLNRLDELAQYFPHGLEYKVAYETTSFVKASIEDVVKTLLEAIALVFLVMYLFLQNFRATLIPTIAVPVVLMGTFSVLYAFGYSVNTLTMFAMVLAIGLLVDDAIVVVENVERIMSEEGLTPREATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGTTGAIYRQFSITIVAAMVLSVLVAMILTPALCATLLKPLKKGEHHGQKGFFAWFNQMFNRNAERYEKGVAKILHRSLRWIVIYVLLLGGMVFLFLRLPTSFLPLEDRGMFTTSVQLPSGSTQQQTLKVVEQIEKYYFTHEKDNIMSVFATVGSGPGGNGQNVARMFIRLKDWSERDSKTGTSFAIIERATKAFNQIKEARVIASSPPAISGLGSSAGFDMELQDHAGAGHDALMAARNQLLALAAENPELTRVRHNGLDDSPQLQIDIDQRKAQALGVAIDDINDTLQTAWGSSYVNDFMDRGRVKKVYVQAAAPYRMLPDDINLWYVRNKDGGMVPFSAFATSRWETGSPRLERYNGYSAVEIVGEAAPGVSTGTAMDIMESLVKQLPNGFGLEWTAMSYQERLSGAQAPALYAISLLVVFLCLAALYESWSVPFSVMLVVPLGVIGALLATWMRGLENDVYFQVGLLTVIGLSAKNAILIVEFANEMNQKGHDLFEATLHACRQRLRPILMTSLAFIFGVLPMATSTGAGSGGQHAVGTGVMGGMISATILAIYFVPLFFVLVRRRFPLKPRPE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10014
Length:	1037 (997)
Sequences:	15806 (10032)
Seq/√Len:	317.7

ECOLI - ACRD MDTB ACRF MDTF ACRB MDTC CUSA
BACSU - SWRC SECDF

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
956_D	959_E	4.011	1.00
244_E	247_R	4.004	1.00
62_T	88_A	3.946	1.00
309_R	312_E	3.873	1.00
311_D	314_A	3.852	1.00
247_R	263_G	3.842	1.00
47_A	88_A	3.809	1.00
913_A	1006_G	3.567	1.00
728_D	806_R	3.531	1.00
590_V	624_A	3.458	1.00
529_G	1017_Y	3.372	1.00
304_E	334_K	3.180	1.00
425_L	433_K	3.147	1.00
150_D	153_D	3.067	1.00
248_D	263_G	3.062	1.00
3_N	7_D	3.051	1.00
426_T	429_E	3.046	1.00
585_Q	588_K	3.025	1.00
531_A	962_L	2.976	1.00
75_L	92_L	2.972	1.00
188_L	203_V	2.929	1.00
280_R	594_E	2.880	1.00
758_N	769_V	2.869	1.00
729_I	734_A	2.824	1.00
62_T	82_S	2.820	1.00
734_A	744_I	2.806	1.00
730_D	804_T	2.787	1.00
169_V	305_L	2.778	1.00
58_E	821_S	2.774	1.00
690_G	693_A	2.773	1.00
193_L	198_M	2.745	1.00
693_A	696_A	2.707	1.00
165_P	309_R	2.693	1.00
142_F	158_V	2.686	1.00
247_R	268_V	2.635	1.00
262_L	268_V	2.626	1.00
895_V	948_N	2.588	1.00
76_M	93_S	2.585	1.00
307_L	328_E	2.572	1.00
282_N	607_S	2.552	1.00
345_L	349_A	2.539	1.00
704_L	707_E	2.506	1.00
740_A	743_D	2.501	1.00
251_L	265_V	2.498	1.00
243_P	247_R	2.460	1.00
154_I	321_L	2.457	1.00
378_G	480_L	2.400	1.00
587_L	591_E	2.372	1.00
314_A	322_E	2.369	1.00
697_A	853_F	2.367	1.00
189_D	192_K	2.348	1.00
527_E	966_R	2.310	1.00
76_M	95_K	2.293	1.00
157_Y	321_L	2.278	1.00
632_D	635_E	2.255	1.00
702_L	706_A	2.255	1.00
144_S	148_S	2.248	1.00
730_D	733_K	2.242	1.00
917_R	1002_T	2.235	1.00
186_I	207_I	2.231	1.00
955_H	963_H	2.229	1.00
382_V	476_A	2.221	1.00
833_V	841_I	2.220	1.00
573_T	628_I	2.216	1.00
246_F	262_L	2.215	1.00
696_A	700_Q	2.209	1.00
301_A	305_L	2.154	1.00
204_T	771_V	2.142	1.00
188_L	200_A	2.134	1.00
419_I	425_L	2.129	1.00
145_T	322_E	2.122	1.00
729_I	744_I	2.119	1.00
182_Y	270_M	2.113	1.00
782_D	785_N	2.099	1.00
950_M	953_K	2.086	1.00
951_N	1023_F	2.084	1.00
419_I	437_Q	2.078	1.00
705_A	842_M	2.057	1.00
187_W	269_E	2.050	1.00
597_Y	650_A	2.031	1.00
535_H	958_F	2.018	1.00
65_I	69_M	2.013	1.00
65_I	90_V	2.012	1.00
987_A	1005_M	2.011	1.00
961_T	1024_V	2.005	1.00
702_L	716_H	2.004	1.00
739_V	789_V	1.995	1.00
252_R	255_Q	1.992	1.00
342_K	346_E	1.982	1.00
728_D	804_T	1.978	1.00
602_K	649_R	1.972	1.00
950_M	955_H	1.968	1.00
727_I	803_A	1.966	1.00
599_T	653_A	1.959	1.00
713_R	828_E	1.958	1.00
577_L	581_S	1.956	1.00
685_D	701_L	1.951	1.00
798_P	801_A	1.947	1.00
711_L	714_V	1.937	1.00
726_Q	808_E	1.922	1.00
785_N	800_S	1.922	1.00
834_S	837_T	1.903	1.00
280_R	587_L	1.901	1.00
708_N	841_I	1.889	1.00
526_Y	965_C	1.886	1.00
415_N	437_Q	1.879	1.00
701_L	846_V	1.873	1.00
521_R	524_E	1.871	1.00
553_F	556_L	1.870	1.00
57_L	61_V	1.864	1.00
429_E	433_K	1.857	1.00
10_I	887_A	1.856	1.00
606_M	631_K	1.849	1.00
371_A	484_V	1.836	1.00
699_N	702_L	1.833	1.00
55_Q	59_N	1.828	1.00
532_K	536_R	1.826	1.00
242_T	245_Q	1.826	1.00
143_V	324_K	1.799	1.00
780_L	783_D	1.798	1.00
149_M	320_G	1.798	1.00
193_L	265_V	1.796	1.00
450_S	479_V	1.791	1.00
537_S	1024_V	1.785	1.00
546_L	550_G	1.778	1.00
305_L	308_N	1.773	1.00
190_P	777_Y	1.767	1.00
841_I	844_S	1.753	1.00
162_I	313_L	1.752	1.00
62_T	80_S	1.747	1.00
843_E	847_K	1.746	1.00
183_S	770_Y	1.744	1.00
702_L	714_V	1.740	1.00
843_E	865_R	1.739	1.00
950_M	963_H	1.739	1.00
244_E	248_D	1.736	1.00
958_F	1024_V	1.734	1.00
698_R	823_V	1.725	1.00
69_M	92_L	1.719	1.00
697_A	700_Q	1.717	1.00
8_R	891_E	1.715	1.00
7_D	428_R	1.713	1.00
739_V	802_F	1.712	1.00
592_Q	595_K	1.709	1.00
521_R	525_R	1.705	1.00
92_L	107_V	1.699	1.00
69_M	90_V	1.695	1.00
267_T	774_A	1.693	1.00
204_T	208_E	1.684	1.00
596_Y	653_A	1.680	1.00
419_I	423_E	1.678	1.00
590_V	610_A	1.675	1.00
388_Y	472_I	1.673	1.00
679_F	827_G	1.672	1.00
24_T	28_F	1.670	1.00
181_Q	273_E	1.664	1.00
211_N	758_N	1.664	1.00
198_M	202_D	1.662	1.00
919_L	1002_T	1.660	1.00
536_R	539_R	1.652	1.00
418_R	423_E	1.648	1.00
733_K	736_A	1.647	1.00
711_L	838_A	1.635	1.00
29_S	384_Y	1.635	1.00
241_Q	245_Q	1.631	1.00
415_N	418_R	1.627	1.00
65_I	114_A	1.624	1.00
527_E	531_A	1.623	1.00
145_T	284_K	1.621	1.00
571_F	628_I	1.616	1.00
744_I	802_F	1.612	1.00
552_V	556_L	1.608	1.00
82_S	88_A	1.607	1.00
651_T	713_R	1.602	1.00
726_Q	806_R	1.597	1.00
532_K	535_H	1.596	1.00
20_C	377_M	1.596	1.00
595_K	599_T	1.595	1.00
541_I	545_V	1.593	1.00
304_E	308_N	1.592	1.00
948_N	952_Q	1.586	1.00
734_A	739_V	1.582	1.00
199_T	202_D	1.582	1.00
649_R	653_A	1.581	1.00
307_L	325_V	1.578	1.00
301_A	304_E	1.578	1.00
597_Y	605_I	1.574	1.00
774_A	777_Y	1.567	1.00
602_K	653_A	1.560	1.00
418_R	967_Q	1.556	1.00
596_Y	656_Q	1.554	1.00
902_V	940_A	1.554	1.00
3_N	432_R	1.554	1.00
141_A	281_F	1.553	1.00
840_D	843_E	1.542	1.00
240_L	246_F	1.540	1.00
74_N	98_T	1.537	1.00
386_F	476_A	1.537	1.00
591_E	595_K	1.535	1.00
338_E	342_K	1.532	1.00
189_D	267_T	1.532	1.00
207_I	249_I	1.531	1.00
575_V	590_V	1.528	1.00
593_I	654_F	1.526	1.00
529_G	532_K	1.525	1.00
188_L	193_L	1.525	1.00
883_F	896_P	1.524	1.00
575_V	593_I	1.524	1.00
408_D	938_K	1.515	1.00
479_V	483_L	1.514	1.00
695_M	699_N	1.513	1.00
248_D	261_R	1.508	1.00
560_T	836_G	1.504	1.00
47_A	62_T	1.502	1.00
26_A	381_S	1.501	1.00
297_A	302_T	1.500	1.00
757_V	771_V	1.496	1.00
416_V	493_C	1.494	1.00
142_F	162_I	1.484	1.00
833_V	837_T	1.480	1.00
586_T	624_A	1.478	1.00
78_M	92_L	1.477	1.00
604_N	638_S	1.474	1.00
791_N	795_G	1.472	1.00
685_D	694_L	1.469	1.00
841_I	845_L	1.467	1.00
115_M	124_N	1.465	1.00
472_I	476_A	1.460	1.00
234_I	752_W	1.456	1.00
710_E	841_I	1.453	1.00
577_L	589_V	1.452	1.00
379_T	477_A	1.448	1.00
704_L	845_L	1.445	1.00
703_A	707_E	1.444	1.00
700_Q	703_A	1.438	1.00
192_K	196_F	1.438	1.00
61_V	122_V	1.437	1.00
99_D	102_E	1.434	1.00
756_Y	768_K	1.431	1.00
638_S	649_R	1.427	1.00
172_V	291_V	1.427	1.00
43_V	107_V	1.425	1.00
307_L	311_D	1.423	1.00
47_A	122_V	1.421	1.00
548_L	552_V	1.419	1.00
571_F	647_I	1.416	1.00
202_D	205_D	1.412	1.00
575_V	624_A	1.411	1.00
205_D	209_S	1.411	1.00
328_E	331_S	1.408	1.00
202_D	790_R	1.408	1.00
339_D	342_K	1.407	1.00
789_V	802_F	1.407	1.00
727_I	805_S	1.406	1.00
648_E	652_K	1.406	1.00
34_Q	568_R	1.401	1.00
604_N	646_I	1.399	1.00
693_A	697_A	1.398	1.00
201_K	205_D	1.394	1.00
14_V	884_L	1.393	1.00
199_T	790_R	1.392	1.00
412_V	435_M	1.391	1.00
840_D	844_S	1.390	1.00
863_Q	866_L	1.388	1.00
688_G	853_F	1.387	1.00
542_V	546_L	1.382	1.00
205_D	208_E	1.380	1.00
98_T	103_A	1.379	1.00
602_K	646_I	1.376	1.00
541_I	1025_L	1.375	1.00
581_S	585_Q	1.374	1.00
591_E	594_E	1.374	1.00
653_A	656_Q	1.370	1.00
525_R	528_K	1.366	1.00
57_L	82_S	1.361	1.00
537_S	1028_R	1.355	1.00
317_F	323_Y	1.353	1.00
47_A	65_I	1.349	1.00
66_E	816_R	1.348	1.00
45_V	69_M	1.346	1.00
958_F	962_L	1.346	1.00
790_R	796_M	1.342	1.00
261_R	264_D	1.341	1.00
605_I	628_I	1.341	1.00
571_F	650_A	1.339	1.00
951_N	1027_R	1.339	1.00
594_E	598_F	1.336	1.00
163_Q	167_S	1.335	1.00
837_T	840_D	1.335	1.00
846_V	855_L	1.333	1.00
349_A	353_L	1.333	1.00
240_L	249_I	1.332	1.00
423_E	433_K	1.331	1.00
192_K	195_S	1.331	1.00
698_R	716_H	1.330	1.00
352_F	369_T	1.326	1.00
595_K	598_F	1.325	1.00
700_Q	704_L	1.317	1.00
596_Y	602_K	1.317	1.00
980_I	1005_M	1.316	1.00
612_V	624_A	1.314	1.00
170_N	305_L	1.313	1.00
604_N	631_K	1.309	1.00
550_G	554_L	1.306	1.00
631_K	635_E	1.306	1.00
53_S	56_T	1.305	1.00
382_V	386_F	1.302	1.00
425_L	429_E	1.302	1.00
209_S	735_Q	1.302	1.00
525_R	529_G	1.302	1.00
305_L	309_R	1.294	1.00
936_S	1011_A	1.292	1.00
45_V	92_L	1.291	1.00
598_F	608_V	1.290	1.00
527_E	963_H	1.289	1.00
69_M	107_V	1.288	1.00
374_V	488_L	1.288	1.00
279_S	288_G	1.287	1.00
143_V	322_E	1.286	1.00
77_Y	818_N	1.286	1.00
549_G	553_F	1.285	1.00
250_T	259_E	1.285	1.00
703_A	706_A	1.282	1.00
19_L	378_G	1.282	1.00
245_Q	248_D	1.281	1.00
58_E	816_R	1.276	1.00
63_Q	816_R	1.276	1.00
22_T	381_S	1.276	1.00
77_Y	93_S	1.274	1.00
980_I	1009_I	1.274	1.00
608_V	626_M	1.271	1.00
112_Q	115_M	1.270	1.00
278_L	587_L	1.268	1.00
711_L	827_G	1.267	1.00
202_D	252_R	1.262	1.00
203_V	265_V	1.260	1.00
145_T	148_S	1.259	1.00
588_K	592_Q	1.256	1.00
739_V	792_K	1.255	1.00
553_F	557_R	1.254	1.00
542_V	549_G	1.254	1.00
947_A	961_T	1.249	1.00
684_Q	817_Y	1.246	1.00
959_E	963_H	1.245	1.00
193_L	203_V	1.243	1.00
13_W	893_W	1.240	1.00
914_T	925_F	1.240	1.00
6_I	491_A	1.240	1.00
957_L	961_T	1.239	1.00
4_F	11_F	1.238	1.00
69_M	78_M	1.236	1.00
165_P	316_Y	1.233	1.00
27_I	341_V	1.232	1.00
43_V	104_V	1.229	1.00
910_A	929_L	1.226	1.00
156_D	767_K	1.222	1.00
415_N	946_F	1.221	1.00
652_K	655_N	1.221	1.00
528_K	531_A	1.211	1.00
590_V	612_V	1.210	1.00
984_L	1005_M	1.206	1.00
419_I	433_K	1.205	1.00
533_I	1021_L	1.205	1.00
216_V	236_A	1.204	1.00
65_I	111_L	1.204	1.00
142_F	323_Y	1.201	1.00
955_H	959_E	1.200	1.00
724_Q	810_G	1.198	1.00
310_L	323_Y	1.195	1.00
951_N	957_L	1.193	1.00
6_I	432_R	1.192	1.00
247_R	267_T	1.191	1.00
524_E	528_K	1.191	1.00
3_N	436_G	1.190	1.00
710_E	833_V	1.186	1.00
26_A	384_Y	1.185	1.00
577_L	586_T	1.185	1.00
309_R	313_L	1.184	1.00
783_D	786_L	1.183	1.00
218_Q	231_N	1.181	1.00
75_L	78_M	1.180	1.00
187_W	267_T	1.178	1.00
149_M	153_D	1.177	1.00
74_N	95_K	1.174	1.00
304_E	307_L	1.171	1.00
140_I	325_V	1.170	1.00
433_K	436_G	1.168	1.00
685_D	697_A	1.167	1.00
58_E	814_L	1.166	1.00
308_N	312_E	1.165	1.00
708_N	845_L	1.164	1.00
57_L	88_A	1.163	1.00
68_N	114_A	1.163	1.00
157_Y	161_N	1.161	1.00
527_E	962_L	1.160	1.00
172_V	302_T	1.157	1.00
973_L	977_L	1.157	1.00
689_A	853_F	1.156	1.00
339_D	997_Q	1.155	1.00
166_L	175_I	1.152	1.00
919_L	998_H	1.149	1.00
701_L	825_I	1.148	1.00
250_T	261_R	1.146	1.00
858_T	862_Y	1.146	1.00
140_I	323_Y	1.145	1.00
648_E	651_T	1.143	1.00
110_Q	113_S	1.143	1.00
388_Y	394_T	1.140	1.00
530_V	534_L	1.139	1.00
687_A	822_A	1.136	1.00
206_A	249_I	1.135	1.00
705_A	711_L	1.134	1.00
311_D	315_Q	1.132	1.00
379_T	476_A	1.132	1.00
138_L	306_V	1.131	1.00
948_N	951_N	1.131	1.00
592_Q	596_Y	1.130	1.00
149_M	321_L	1.128	1.00
49_Y	52_A	1.125	1.00
589_V	592_Q	1.124	1.00
196_F	260_V	1.123	1.00
446_A	482_V	1.122	1.00
262_L	266_A	1.121	1.00
76_M	866_L	1.119	1.00
820_Y	854_G	1.119	1.00
370_I	492_L	1.119	1.00
693_A	853_F	1.117	1.00
817_Y	858_T	1.117	1.00
449_L	938_K	1.114	1.00
708_N	844_S	1.111	1.00
592_Q	657_I	1.111	1.00
561_S	920_E	1.110	1.00
20_C	24_T	1.108	1.00
303_A	330_T	1.106	1.00
526_Y	530_V	1.105	1.00
515_F	519_F	1.103	1.00
838_A	841_I	1.103	1.00
298_N	301_A	1.103	1.00
869_A	872_P	1.102	1.00
749_Q	755_S	1.100	1.00
557_R	915_W	1.100	1.00
165_P	313_L	1.099	1.00
592_Q	659_E	1.096	1.00
905_L	1014_L	1.094	1.00
772_Q	778_R	1.089	1.00
16_A	488_L	1.087	1.00
528_K	532_K	1.085	1.00
759_D	768_K	1.084	1.00
447_M	885_C	1.083	1.00
248_D	732_R	1.082	1.00
11_F	888_A	1.081	1.00
963_H	966_R	1.080	1.00
493_C	497_L	1.080	1.00
141_A	286_A	1.080	1.00
922_D	925_F	1.078	1.00
445_I	482_V	1.077	1.00
946_F	950_M	1.076	1.00
142_F	154_I	1.074	1.00
5_F	12_A	1.073	1.00
549_G	552_V	1.071	1.00
415_N	419_I	1.070	1.00
742_D	746_D	1.070	1.00
699_N	703_A	1.068	1.00
697_A	849_L	1.066	1.00
688_G	693_A	1.065	1.00
334_K	338_E	1.065	1.00
596_Y	599_T	1.065	1.00
594_E	610_A	1.064	1.00
731_Q	741_I	1.064	1.00
606_M	629_R	1.063	1.00
81_Q	91_T	1.062	1.00
155_A	180_S	1.057	1.00
115_M	123_Q	1.056	1.00
138_L	307_L	1.054	1.00
561_S	922_D	1.052	1.00
175_I	289_L	1.051	1.00
66_E	80_S	1.049	1.00
977_L	981_F	1.048	1.00
596_Y	657_I	1.048	1.00
235_N	724_Q	1.048	1.00
953_K	963_H	1.047	1.00
185_R	772_Q	1.046	1.00
78_M	819_G	1.046	1.00
308_N	311_D	1.045	1.00
788_Y	796_M	1.045	1.00
554_L	912_L	1.044	1.00
533_I	1017_Y	1.043	1.00
545_V	549_G	1.043	1.00
312_E	315_Q	1.042	1.00
68_N	113_S	1.040	1.00
842_M	857_W	1.040	1.00
706_A	714_V	1.038	1.00
79_S	93_S	1.038	1.00
969_L	973_L	1.037	1.00
45_V	65_I	1.035	1.00
597_Y	626_M	1.033	1.00
890_Y	941_I	1.033	1.00
314_A	323_Y	1.032	1.00
371_A	489_T	1.031	1.00
913_A	1002_T	1.026	1.00
261_R	732_R	1.026	1.00
80_S	816_R	1.025	1.00
682_E	824_E	1.022	1.00
98_T	106_Q	1.022	1.00
862_Y	866_L	1.020	1.00
588_K	591_E	1.019	1.00
980_I	1008_M	1.019	1.00
201_K	743_D	1.017	1.00
638_S	645_A	1.017	1.00
108_Q	112_Q	1.017	1.00
539_R	542_V	1.016	1.00
786_L	800_S	1.014	1.00
371_A	409_A	1.014	1.00
602_K	650_A	1.013	1.00
976_S	980_I	1.012	1.00
187_W	774_A	1.011	1.00
829_A	838_A	1.011	1.00
428_R	432_R	1.010	1.00
251_L	260_V	1.009	1.00
444_G	885_C	1.007	1.00
589_V	657_I	1.006	1.00
424_G	430_A	1.005	1.00
976_S	1012_T	1.005	1.00
710_E	830_A	1.005	1.00
46_T	87_Q	1.004	1.00
593_I	657_I	1.003	1.00
30_L	380_F	1.003	1.00
186_I	757_V	1.002	1.00
429_E	432_R	1.001	1.00
367_I	492_L	1.001	1.00
246_F	268_V	1.000	1.00
946_F	967_Q	1.000	1.00
912_L	916_M	0.999	1.00
949_E	953_K	0.999	1.00
692_D	695_M	0.998	1.00
750_T	755_S	0.996	1.00
638_S	646_I	0.996	1.00
216_V	748_L	0.996	1.00
143_V	284_K	0.995	1.00
370_I	488_L	0.995	1.00
784_I	805_S	0.994	1.00
20_C	374_V	0.992	1.00
585_Q	659_E	0.992	1.00
546_L	549_G	0.991	1.00
415_N	438_I	0.991	1.00
702_L	825_I	0.989	1.00
575_V	662_V	0.988	1.00
427_P	431_T	0.987	1.00
949_E	952_Q	0.987	1.00
538_L	542_V	0.986	1.00
102_E	106_Q	0.986	1.00
645_A	649_R	0.984	1.00
214_I	745_N	0.983	1.00
791_N	794_G	0.983	1.00
981_F	984_L	0.981	1.00
533_I	540_W	0.979	1.00
520_N	524_E	0.978	1.00
544_Y	1018_F	0.977	1.00
80_S	90_V	0.977	1.00
444_G	889_L	0.976	1.00
683_L	705_A	0.976	1.00
303_A	307_L	0.976	1.00
725_L	781_P	0.973	1.00
382_V	480_L	0.972	1.00
144_S	320_G	0.972	1.00
307_L	330_T	0.971	1.00
739_V	744_I	0.971	1.00
535_H	538_L	0.970	1.00
518_M	521_R	0.969	1.00
163_Q	175_I	0.967	1.00
517_Q	521_R	0.966	1.00
280_R	591_E	0.965	1.00
45_V	90_V	0.965	1.00
439_Q	443_V	0.965	1.00
543_I	550_G	0.965	1.00
231_N	276_D	0.962	1.00
538_L	1025_L	0.959	1.00
687_A	856_E	0.957	1.00
138_L	303_A	0.957	1.00
48_N	87_Q	0.956	1.00
94_F	107_V	0.955	1.00
963_H	967_Q	0.954	1.00
571_F	630_L	0.954	1.00
551_M	911_L	0.954	1.00
451_A	881_V	0.954	1.00
644_F	648_E	0.953	1.00
207_I	757_V	0.953	1.00
685_D	825_I	0.951	1.00
582_T	585_Q	0.949	1.00
281_F	286_A	0.949	1.00
593_I	626_M	0.949	1.00
701_L	845_L	0.945	1.00
420_M	427_P	0.944	1.00
597_Y	628_I	0.943	1.00
947_A	1023_F	0.941	1.00
683_L	701_L	0.939	1.00
183_S	273_E	0.939	1.00
246_F	769_V	0.938	1.00
70_T	819_G	0.937	1.00
449_L	478_M	0.937	1.00
145_T	320_G	0.935	1.00
898_S	1022_F	0.934	1.00
698_R	702_L	0.934	1.00
394_T	469_Q	0.932	1.00
185_R	269_E	0.932	1.00
13_W	17_I	0.932	1.00
650_A	654_F	0.931	1.00
760_F	769_V	0.931	1.00
144_S	149_M	0.931	1.00
198_M	251_L	0.931	1.00
341_V	345_L	0.930	1.00
650_A	664_A	0.930	1.00
573_T	597_Y	0.929	1.00
207_I	246_F	0.928	1.00
910_A	1003_G	0.927	1.00
685_D	853_F	0.926	1.00
247_R	266_A	0.926	1.00
437_Q	949_E	0.925	1.00
534_L	1024_V	0.924	1.00
360_Q	516_N	0.923	1.00
649_R	652_K	0.921	1.00
178_Y	290_G	0.918	1.00
163_Q	177_A	0.916	1.00
383_L	388_Y	0.915	1.00
169_V	309_R	0.914	1.00
537_S	1025_L	0.914	1.00
460_G	870_Q	0.913	1.00
814_L	821_S	0.910	1.00
599_T	602_K	0.910	1.00
913_A	917_R	0.909	1.00
594_E	608_V	0.908	1.00
759_D	766_V	0.908	1.00
47_A	125_Q	0.906	1.00
646_I	649_R	0.905	1.00
307_L	314_A	0.905	1.00
416_V	434_S	0.904	1.00
565_L	644_F	0.902	1.00
756_Y	770_Y	0.901	1.00
148_S	320_G	0.901	1.00
962_L	966_R	0.901	1.00
984_L	988_T	0.900	1.00
743_D	746_D	0.899	1.00
785_N	805_S	0.899	1.00
193_L	196_F	0.899	1.00
540_W	543_I	0.898	1.00
412_V	442_L	0.897	1.00
68_N	117_K	0.897	1.00
203_V	771_V	0.897	1.00
16_A	374_V	0.896	1.00
734_A	802_F	0.895	1.00
717_N	815_E	0.895	1.00
575_V	660_A	0.894	1.00
961_T	965_C	0.893	1.00
189_D	777_Y	0.892	1.00
7_D	432_R	0.891	1.00
374_V	484_V	0.889	1.00
523_A	527_E	0.888	1.00
905_L	1018_F	0.882	1.00
908_I	1010_S	0.881	1.00
432_R	436_G	0.878	1.00
198_M	203_V	0.876	1.00
576_Q	661_R	0.874	1.00
682_E	822_A	0.874	1.00
605_I	613_G	0.874	1.00
283_G	594_E	0.873	1.00
645_A	648_E	0.871	1.00
518_M	522_N	0.871	1.00
779_M	783_D	0.871	1.00
531_A	959_E	0.868	1.00
705_A	714_V	0.868	1.00
243_P	270_M	0.868	1.00
302_T	305_L	0.866	1.00
190_P	773_A	0.866	1.00
71_G	110_Q	0.866	1.00
166_L	309_R	0.865	1.00
571_F	664_A	0.865	1.00
431_T	494_A	0.864	1.00
186_I	266_A	0.864	1.00
362_F	366_L	0.863	1.00
438_I	446_A	0.863	1.00
174_D	292_K	0.863	1.00
651_T	664_A	0.863	1.00
313_L	317_F	0.862	1.00
707_E	845_L	0.862	1.00
897_F	901_L	0.861	1.00
604_N	649_R	0.860	1.00
62_T	90_V	0.858	1.00
1015_A	1019_V	0.857	1.00
947_A	964_A	0.856	1.00
643_S	647_I	0.856	1.00
581_S	586_T	0.855	1.00
694_L	853_F	0.854	1.00
872_P	876_A	0.852	1.00
727_I	748_L	0.852	1.00
156_D	160_S	0.851	1.00
152_Q	272_A	0.850	1.00
693_A	852_G	0.850	1.00
252_R	260_V	0.849	1.00
448_V	938_K	0.849	1.00
338_E	341_V	0.848	1.00
839_M	861_S	0.844	1.00
876_A	880_L	0.842	1.00
439_Q	486_M	0.841	1.00
102_E	105_Q	0.840	1.00
58_E	62_T	0.840	1.00
48_N	123_Q	0.840	1.00
754_S	772_Q	0.838	1.00
541_I	1021_L	0.837	1.00
683_L	855_L	0.837	1.00
879_L	900_M	0.837	1.00
4_F	8_R	0.836	1.00
584_Q	588_K	0.836	1.00
818_N	856_E	0.835	1.00
201_K	746_D	0.835	1.00
700_Q	848_Q	0.831	1.00
725_L	807_W	0.831	1.00
310_L	314_A	0.830	1.00
957_L	1024_V	0.828	1.00
550_G	553_F	0.827	1.00
229_A	585_Q	0.826	1.00
404_L	978_A	0.825	1.00
158_V	289_L	0.823	1.00
317_F	321_L	0.822	1.00
47_A	82_S	0.822	1.00
44_R	91_T	0.822	1.00
883_F	893_W	0.821	1.00
155_A	159_A	0.820	1.00
534_L	1021_L	0.820	1.00
850_P	853_F	0.819	1.00
404_L	979_F	0.818	1.00
680_D	828_E	0.816	1.00
153_D	156_D	0.814	1.00
547_L	908_I	0.814	1.00
397_A	401_A	0.814	1.00
692_D	696_A	0.813	1.00
1009_I	1013_I	0.813	1.00
346_E	349_A	0.812	1.00
209_S	740_A	0.812	1.00
404_L	408_D	0.811	1.00
939_N	1011_A	0.811	1.00
49_Y	57_L	0.810	1.00
573_T	664_A	0.810	1.00
184_M	760_F	0.809	1.00
139_T	290_G	0.809	1.00
347_A	351_V	0.809	1.00
751_A	787_W	0.807	1.00
587_L	612_V	0.805	1.00
573_T	626_M	0.805	1.00
137_I	303_A	0.804	1.00
922_D	999_A	0.803	1.00
571_F	643_S	0.803	1.00
737_L	797_V	0.803	1.00
204_T	750_T	0.802	1.00
77_Y	817_Y	0.802	1.00
281_F	607_S	0.802	1.00
718_G	823_V	0.801	1.00
381_S	385_A	0.800	1.00
120_Q	124_N	0.800	1.00
534_L	961_T	0.799	1.00
714_V	827_G	0.797	1.00
1012_T	1015_A	0.797	1.00
10_I	893_W	0.796	1.00
441_A	949_E	0.796	1.00
191_A	786_L	0.795	1.00
449_L	979_F	0.795	1.00
685_D	690_G	0.795	1.00
657_I	660_A	0.795	1.00
954_G	960_A	0.795	1.00
203_V	262_L	0.794	1.00
232_A	725_L	0.793	1.00
465_A	468_R	0.793	1.00
534_L	962_L	0.792	1.00
1022_F	1026_V	0.792	1.00
744_I	799_F	0.792	1.00
711_L	842_M	0.791	1.00
204_T	755_S	0.791	1.00
725_L	805_S	0.791	1.00
50_P	123_Q	0.791	1.00
203_V	206_A	0.789	1.00
81_Q	813_R	0.789	1.00
839_M	857_W	0.789	1.00
46_T	89_S	0.789	1.00
167_S	174_D	0.788	1.00
917_R	1006_G	0.787	1.00
200_A	750_T	0.786	1.00
523_A	966_R	0.786	1.00
712_T	830_A	0.785	1.00
278_L	583_Q	0.785	1.00
488_L	492_L	0.784	1.00
558_L	911_L	0.783	1.00
551_M	554_L	0.783	1.00
695_M	823_V	0.782	1.00
188_L	266_A	0.782	1.00
413_V	493_C	0.781	1.00
13_W	495_T	0.781	1.00
697_A	701_L	0.780	1.00
118_L	122_V	0.779	1.00
253_V	259_E	0.778	1.00
273_E	768_K	0.774	1.00
240_L	760_F	0.773	1.00
938_K	978_A	0.772	1.00
457_A	475_V	0.771	1.00
739_V	791_N	0.770	1.00
610_A	626_M	0.770	1.00
531_A	958_F	0.770	1.00
231_N	621_Q	0.768	0.99
733_K	801_A	0.768	0.99
94_F	103_A	0.768	0.99
358_F	974_M	0.767	0.99
839_M	865_R	0.766	0.99
169_V	302_T	0.766	0.99
137_I	302_T	0.765	0.99
687_A	854_G	0.765	0.99
140_I	289_L	0.764	0.99
2_A	435_M	0.764	0.99
361_N	364_A	0.764	0.99
188_L	771_V	0.762	0.99
177_A	180_S	0.762	0.99
520_N	523_A	0.762	0.99
141_A	288_G	0.761	0.99
246_F	249_I	0.761	0.99
279_S	286_A	0.760	0.99
383_L	473_T	0.760	0.99
555_F	911_L	0.760	0.99
445_I	978_A	0.759	0.99
921_N	926_Q	0.758	0.99
593_I	596_Y	0.757	0.99
849_L	855_L	0.756	0.99
1024_V	1028_R	0.756	0.99
694_L	823_V	0.756	0.99
747_T	789_V	0.755	0.99
781_P	785_N	0.755	0.99
914_T	1003_G	0.754	0.99
816_R	821_S	0.754	0.99
250_T	253_V	0.753	0.99
551_M	908_I	0.753	0.99
531_A	535_H	0.752	0.99
749_Q	753_G	0.751	0.99
607_S	629_R	0.751	0.99
194_N	788_Y	0.751	0.99
95_K	98_T	0.751	0.99
25_L	29_S	0.750	0.99
450_S	475_V	0.750	0.99
519_F	523_A	0.748	0.99
141_A	326_A	0.748	0.99
69_M	111_L	0.748	0.99
751_A	773_A	0.747	0.99
750_T	771_V	0.747	0.99
6_I	431_T	0.746	0.99
299_E	330_T	0.746	0.99
533_I	536_R	0.744	0.99
138_L	325_V	0.744	0.99
52_A	57_L	0.743	0.99
159_A	163_Q	0.743	0.99
368_P	413_V	0.743	0.99
1010_S	1014_L	0.743	0.99
288_G	609_F	0.742	0.99
379_T	480_L	0.742	0.99
632_D	636_R	0.741	0.99
556_L	559_P	0.740	0.99
830_A	833_V	0.740	0.99
418_R	437_Q	0.738	0.99
717_N	822_A	0.738	0.99
861_S	865_R	0.738	0.99
337_I	395_M	0.736	0.99
37_D	296_G	0.736	0.99
585_Q	589_V	0.735	0.99
939_N	976_S	0.735	0.99
138_L	310_L	0.735	0.99
203_V	251_L	0.734	0.99
943_I	965_C	0.733	0.99
428_R	494_A	0.733	0.99
166_L	289_L	0.733	0.99
331_S	334_K	0.732	0.99
74_N	97_G	0.732	0.99
445_I	938_K	0.732	0.99
868_G	872_P	0.731	0.99
249_I	262_L	0.728	0.99
142_F	289_L	0.728	0.99
363_R	497_L	0.728	0.99
239_L	761_M	0.728	0.99
921_N	929_L	0.728	0.99
391_N	394_T	0.727	0.99
688_G	852_G	0.727	0.99
957_L	1028_R	0.726	0.99
278_L	612_V	0.726	0.99
186_I	771_V	0.725	0.99
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72_L	75_L	0.544	0.95
483_L	487_I	0.544	0.95
445_I	976_S	0.543	0.95
355_M	406_V	0.541	0.95
727_I	744_I	0.541	0.95
368_P	978_A	0.541	0.95
599_T	603_D	0.541	0.95
136_N	292_K	0.540	0.95
739_V	743_D	0.540	0.95
879_L	933_I	0.540	0.95
348_I	351_V	0.539	0.95
326_A	609_F	0.539	0.95
196_F	265_V	0.539	0.95
894_S	1026_V	0.538	0.95
562_F	867_S	0.538	0.95
283_G	595_K	0.538	0.95
856_E	862_Y	0.537	0.95
139_T	327_Y	0.536	0.95
140_I	307_L	0.536	0.95
836_G	840_D	0.535	0.95
442_L	486_M	0.535	0.95
5_F	8_R	0.535	0.95
49_Y	121_A	0.535	0.95
120_Q	123_Q	0.535	0.95
652_K	707_E	0.535	0.95
149_M	157_Y	0.535	0.95
752_W	787_W	0.534	0.95
445_I	890_Y	0.534	0.95
376_L	398_M	0.534	0.95
529_G	533_I	0.533	0.95
397_A	473_T	0.533	0.95
945_E	949_E	0.533	0.95
177_A	287_S	0.532	0.94
696_A	699_N	0.532	0.94
643_S	666_S	0.532	0.94
883_F	900_M	0.532	0.94
968_R	975_T	0.531	0.94
684_Q	824_E	0.531	0.94
364_A	417_E	0.531	0.94
342_K	345_L	0.531	0.94
213_Q	239_L	0.531	0.94
166_L	169_V	0.530	0.94
209_S	743_D	0.530	0.94
282_N	324_K	0.530	0.94
593_I	660_A	0.530	0.94
130_R	174_D	0.529	0.94
522_N	525_R	0.529	0.94
353_L	357_L	0.529	0.94
446_A	485_A	0.529	0.94
41_P	94_F	0.529	0.94
976_S	979_F	0.528	0.94
538_L	545_V	0.528	0.94
310_L	325_V	0.528	0.94
230_L	580_G	0.528	0.94
396_F	399_V	0.528	0.94
50_P	125_Q	0.527	0.94
336_S	392_T	0.527	0.94
191_A	777_Y	0.527	0.94
965_C	969_L	0.526	0.94
19_L	484_V	0.526	0.94
367_I	493_C	0.526	0.94
171_G	302_T	0.525	0.94
408_D	445_I	0.525	0.94
482_V	486_M	0.525	0.94
30_L	384_Y	0.525	0.94
366_L	496_L	0.524	0.94
994_S	997_Q	0.524	0.94
210_Q	240_L	0.523	0.94
427_P	494_A	0.523	0.94
516_N	520_N	0.523	0.94
746_D	750_T	0.523	0.94
169_V	172_V	0.522	0.94
393_L	399_V	0.522	0.94
396_F	997_Q	0.522	0.94
57_L	62_T	0.522	0.94
467_Y	471_S	0.521	0.94
351_V	399_V	0.521	0.94
32_V	390_V	0.520	0.94
46_T	128_T	0.520	0.94
951_N	956_D	0.520	0.94
58_E	82_S	0.520	0.94
714_V	828_E	0.520	0.94
646_I	650_A	0.518	0.94
310_L	313_L	0.518	0.94
365_T	931_T	0.517	0.94
410_I	974_M	0.516	0.94
716_H	825_I	0.516	0.94
938_K	976_S	0.516	0.94
270_M	767_K	0.516	0.94
871_A	926_Q	0.516	0.94
574_S	623_V	0.515	0.93
37_D	133_G	0.515	0.93
602_K	638_S	0.515	0.93
785_N	804_T	0.515	0.93
348_I	369_T	0.514	0.93
869_A	873_A	0.514	0.93
198_M	790_R	0.514	0.93
925_F	999_A	0.514	0.93
842_M	845_L	0.514	0.93
442_L	445_I	0.512	0.93
52_A	82_S	0.512	0.93
412_V	486_M	0.512	0.93
139_T	178_Y	0.511	0.93
13_W	492_L	0.511	0.93
12_A	491_A	0.510	0.93
747_T	751_A	0.510	0.93
539_R	549_G	0.510	0.93
901_L	1019_V	0.510	0.93
906_G	1019_V	0.510	0.93
155_A	287_S	0.510	0.93
594_E	612_V	0.510	0.93
716_H	823_V	0.509	0.93
37_D	295_S	0.509	0.93
69_M	72_L	0.509	0.93
874_L	877_I	0.509	0.93
697_A	855_L	0.508	0.93
157_Y	162_I	0.508	0.93
554_L	557_R	0.508	0.93
116_R	123_Q	0.508	0.93
216_V	727_I	0.507	0.93
10_I	13_W	0.507	0.93
343_T	982_G	0.507	0.93
420_M	499_P	0.506	0.93
457_A	471_S	0.506	0.93
633_W	636_R	0.505	0.93
48_N	86_G	0.505	0.93
43_V	127_V	0.504	0.93
169_V	306_V	0.504	0.93
186_I	265_V	0.503	0.93
411_V	442_L	0.503	0.93
21_L	880_L	0.502	0.93
701_L	842_M	0.502	0.93
832_G	837_T	0.502	0.93
724_Q	808_E	0.502	0.93
343_T	979_F	0.502	0.93
314_A	318_P	0.502	0.93
745_N	748_L	0.501	0.93
913_A	1010_S	0.501	0.93
177_A	289_L	0.500	0.92
550_G	556_L	0.500	0.92
691_H	718_G	0.500	0.92
105_Q	108_Q	0.500	0.92

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4k0jA	3	0.9277	100	0.21	Contact Map
4mt1A	3	0.9701	100	0.27	Contact Map
3w9iA	3	0.9884	100	0.278	Contact Map
3ne5A	3	0.9595	100	0.28	Contact Map
4dx5A	3	0.9952	100	0.294	Contact Map
3aqpA	1	0.6779	100	0.724	Contact Map
4r86A	1	0.2797	100	0.748	Contact Map
2ew9A	1	0.1427	85.8	0.981	Contact Map
4n8nA	1	0.0964	79.3	0.982	Contact Map
4q2lA	1	0.0617	74.1	0.983	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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