GREMLIN Database
MANB - Phosphomannomutase
UniProt: P24175 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10162
Length: 456 (435)
Sequences: 10828 (6672)
Seq/√Len: 319.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
232_A236_H4.0441.00
317_R320_K3.9891.00
182_A248_F3.6931.00
174_V238_A3.5941.00
256_E363_G3.2921.00
231_N235_K3.2091.00
160_F195_A2.7911.00
30_R65_A2.7791.00
49_L212_N2.7781.00
294_V306_M2.7101.00
172_K201_E2.7001.00
232_A235_K2.6771.00
86_H154_A2.6461.00
40_T68_D2.6371.00
360_K368_D2.6171.00
305_V317_R2.6081.00
299_A372_A2.5651.00
282_K303_T2.5271.00
188_A195_A2.5131.00
34_E129_L2.3911.00
55_K71_D2.3791.00
272_E300_A2.3211.00
153_D157_D2.3161.00
244_F348_W2.3051.00
41_I62_L2.2501.00
230_R234_I2.2171.00
62_L93_I2.1571.00
29_G58_L2.1511.00
253_L351_V2.1141.00
22_E53_T2.1071.00
43_L59_A2.0911.00
58_L93_I2.0831.00
32_Y91_G2.0661.00
439_D443_M2.0641.00
394_E398_S2.0621.00
295_D298_T2.0501.00
44_G80_I2.0321.00
42_V89_V1.9771.00
45_G55_K1.9711.00
360_K364_E1.9611.00
275_L302_G1.9491.00
33_G62_L1.9311.00
52_E56_L1.9241.00
45_G51_S1.9201.00
227_D231_N1.9101.00
15_K103_D1.9051.00
129_L132_A1.9011.00
33_G65_A1.8731.00
272_E276_E1.8641.00
125_D128_R1.8181.00
259_Q367_R1.8101.00
278_N281_A1.8051.00
82_F86_H1.8041.00
128_R132_A1.7921.00
34_E65_A1.7821.00
63_Q146_Y1.7671.00
153_D188_A1.7571.00
294_V298_T1.7541.00
443_M447_T1.7491.00
174_V232_A1.7431.00
317_R321_E1.7171.00
40_T70_L1.7161.00
32_Y109_L1.7011.00
269_L354_L1.6951.00
391_N395_Q1.6671.00
15_K104_Y1.6631.00
361_T364_E1.6551.00
256_E361_T1.6521.00
156_V189_I1.6491.00
242_I348_W1.6441.00
30_R34_E1.6231.00
297_V302_G1.5881.00
26_W57_A1.5681.00
276_E358_K1.5641.00
257_K363_G1.5621.00
438_G441_P1.5571.00
204_K207_N1.5351.00
172_K203_I1.5331.00
441_P444_E1.5331.00
382_K385_Q1.5231.00
380_N385_Q1.4821.00
127_Q131_E1.4811.00
15_K18_E1.4781.00
231_N234_I1.4711.00
40_T90_D1.4661.00
25_A107_M1.4621.00
117_I126_V1.4571.00
351_V362_L1.4571.00
316_E320_K1.4501.00
188_A194_K1.4481.00
388_E392_R1.4421.00
434_V446_R1.4351.00
157_D195_A1.4231.00
68_D145_R1.4191.00
282_K305_V1.4061.00
233_V241_G1.4051.00
62_L67_V1.4011.00
187_D194_K1.4011.00
440_V444_E1.3981.00
47_V74_M1.3961.00
270_L335_F1.3951.00
285_H304_P1.3861.00
26_W60_K1.3841.00
118_S121_T1.3801.00
177_S207_N1.3751.00
408_D411_S1.3551.00
173_L240_M1.3541.00
307_S317_R1.3471.00
444_E448_R1.3451.00
395_Q399_R1.3431.00
314_I326_G1.3401.00
42_V83_A1.3391.00
201_E236_H1.3381.00
26_W64_D1.3331.00
49_L211_G1.3321.00
295_D437_R1.3311.00
153_D195_A1.3261.00
211_G214_P1.3201.00
70_L149_I1.3131.00
12_I28_I1.3101.00
82_F158_H1.3091.00
272_E368_D1.3051.00
68_D147_Q1.3041.00
267_V327_G1.3031.00
128_R131_E1.2991.00
35_F121_T1.2901.00
172_K236_H1.2841.00
206_H228_D1.2841.00
159_L346_I1.2831.00
45_G52_E1.2821.00
229_T254_F1.2801.00
255_D363_G1.2781.00
29_G107_M1.2771.00
6_C131_E1.2731.00
390_I394_E1.2731.00
240_M352_A1.2691.00
16_L50_T1.2691.00
25_A54_L1.2661.00
33_G67_V1.2631.00
391_N394_E1.2621.00
59_A146_Y1.2601.00
388_E391_N1.2591.00
229_T243_A1.2531.00
162_Y350_L1.2521.00
171_L239_D1.2501.00
59_A63_Q1.2401.00
303_T321_E1.2331.00
62_L69_V1.2301.00
187_D207_N1.2241.00
392_R396_H1.2231.00
271_A283_I1.2181.00
394_E406_R1.2131.00
387_V390_I1.2001.00
75_S79_E1.1921.00
45_G71_D1.1901.00
240_M355_V1.1831.00
172_K237_G1.1831.00
398_S401_A1.1801.00
441_P445_A1.1761.00
292_N369_R1.1751.00
203_I236_H1.1731.00
35_F129_L1.1731.00
355_V365_L1.1641.00
43_L58_L1.1641.00
90_D112_E1.1611.00
389_A392_R1.1591.00
117_I121_T1.1591.00
387_V391_N1.1571.00
363_G367_R1.1571.00
159_L349_L1.1561.00
154_A157_D1.1561.00
392_R395_Q1.1551.00
196_L349_L1.1551.00
436_S442_L1.1541.00
158_H161_G1.1521.00
152_R185_V1.1501.00
360_K365_L1.1431.00
29_G62_L1.1421.00
378_E385_Q1.1391.00
35_F125_D1.1381.00
273_A357_L1.1341.00
234_I257_K1.1331.00
228_D231_N1.1231.00
272_E365_L1.1221.00
387_V423_T1.1191.00
395_Q398_S1.1161.00
150_N153_D1.1161.00
268_G292_N1.1131.00
12_I109_L1.1091.00
41_I91_G1.1071.00
365_L368_D1.1021.00
59_A71_D1.1001.00
227_D230_R1.0911.00
157_D161_G1.0911.00
305_V321_E1.0911.00
55_K59_A1.0871.00
125_D129_L1.0871.00
285_H306_M1.0851.00
182_A244_F1.0761.00
68_D144_G1.0731.00
410_I445_A1.0711.00
84_T92_G1.0661.00
285_H289_L1.0651.00
242_I253_L1.0631.00
70_L147_Q1.0631.00
268_G296_V1.0611.00
396_H400_E1.0601.00
38_P125_D1.0591.00
289_L293_T1.0591.00
379_I447_T1.0561.00
229_T233_V1.0501.00
87_L151_L1.0491.00
93_I107_M1.0471.00
71_D148_Q1.0471.00
364_E367_R1.0461.00
175_I193_F1.0461.00
156_V195_A1.0461.00
296_V300_A1.0431.00
152_R188_A1.0401.00
32_Y93_I1.0391.00
58_L95_V1.0341.00
164_N353_E1.0311.00
22_E57_A1.0301.00
230_R260_F1.0291.00
269_L366_V1.0291.00
80_I94_E1.0281.00
80_I92_G1.0281.00
183_G207_N1.0211.00
193_F348_W1.0211.00
82_F154_A1.0201.00
57_A61_G1.0181.00
124_R128_R1.0111.00
378_E382_K1.0111.00
275_L300_A1.0111.00
86_H158_H1.0111.00
124_R127_Q1.0101.00
47_V209_P1.0091.00
76_G79_E1.0081.00
158_H162_Y1.0081.00
206_H218_P1.0051.00
255_D259_Q1.0051.00
205_V232_A1.0031.00
282_K321_E1.0021.00
38_P129_L1.0011.00
183_G187_D0.9991.00
156_V185_V0.9931.00
24_I28_I0.9911.00
30_R64_D0.9881.00
412_M419_F0.9841.00
318_M323_A0.9841.00
294_V304_P0.9811.00
295_D299_A0.9781.00
353_E357_L0.9751.00
50_T53_T0.9741.00
44_G94_E0.9731.00
58_L62_L0.9701.00
313_F316_E0.9691.00
411_S418_R0.9671.00
72_I75_S0.9651.00
157_D160_F0.9651.00
408_D412_M0.9641.00
55_K95_V0.9631.00
133_N138_V0.9611.00
175_I182_A0.9611.00
56_L60_K0.9551.00
335_F350_L0.9541.00
173_L198_A0.9521.00
233_V254_F0.9511.00
194_K204_K0.9501.00
60_K64_D0.9461.00
267_V293_T0.9431.00
42_V72_I0.9421.00
193_F198_A0.9411.00
31_A130_A0.9401.00
297_V304_P0.9391.00
322_D336_R0.9351.00
229_T241_G0.9351.00
166_K169_T0.9341.00
121_T125_D0.9271.00
193_F352_A0.9271.00
282_K323_A0.9221.00
205_V228_D0.9221.00
171_L355_V0.9181.00
175_I244_F0.9131.00
31_A129_L0.9121.00
120_D125_D0.9041.00
186_V244_F0.9041.00
119_G123_L0.9031.00
354_L358_K0.9011.00
382_K386_P0.9011.00
265_Y366_V0.9001.00
266_I333_H0.8981.00
413_T448_R0.8981.00
172_K239_D0.8931.00
111_R121_T0.8921.00
266_I351_V0.8921.00
139_D142_K0.8871.00
174_V203_I0.8841.00
51_S105_N0.8821.00
403_A413_T0.8811.00
151_L154_A0.8761.00
179_N206_H0.8761.00
283_I293_T0.8701.00
120_D123_L0.8691.00
45_G74_M0.8691.00
325_Y333_H0.8681.00
295_D373_F0.8671.00
259_Q363_G0.8651.00
442_L446_R0.8611.00
253_L266_I0.8581.00
276_E300_A0.8571.00
350_L353_E0.8561.00
117_I123_L0.8521.00
267_V283_I0.8501.00
29_G61_G0.8501.00
160_F196_L0.8491.00
119_G313_F0.8481.00
273_A354_L0.8461.00
283_I297_V0.8461.00
251_C347_P0.8441.00
174_V236_H0.8431.00
149_I153_D0.8431.00
22_E26_W0.8421.00
223_P260_F0.8411.00
272_E369_R0.8401.00
133_N137_P0.8381.00
70_L89_V0.8341.00
296_V299_A0.8331.00
272_E296_V0.8321.00
176_N229_T0.8301.00
44_G75_S0.8281.00
274_F350_L0.8261.00
242_I251_C0.8241.00
152_R184_P0.8231.00
206_H215_N0.8211.00
140_E143_R0.8201.00
383_L386_P0.8201.00
259_Q366_V0.8191.00
185_V345_M0.8181.00
284_I326_G0.8161.00
308_K313_F0.8151.00
83_A151_L0.8121.00
67_V90_D0.8061.00
234_I237_G0.8051.00
224_E227_D0.8051.00
233_V238_A0.8021.00
158_H338_F0.8001.00
256_E364_E0.8001.00
173_L352_A0.8001.00
75_S94_E0.7971.00
40_T89_V0.7951.00
406_R410_I0.7951.00
352_A355_V0.7951.00
74_M181_A0.7941.00
370_M374_P0.7941.00
324_I337_D0.7931.00
266_I270_L0.7901.00
378_E384_A0.7891.00
28_I130_A0.7871.00
405_D413_T0.7851.00
259_Q265_Y0.7851.00
355_V362_L0.7841.00
47_V181_A0.7841.00
29_G33_G0.7831.00
406_R409_G0.7831.00
23_D27_R0.7821.00
171_L240_M0.7781.00
244_F344_G0.7761.00
268_G290_S0.7741.00
269_L365_L0.7711.00
295_D376_S0.7711.00
73_G184_P0.7701.00
252_F260_F0.7681.00
87_L154_A0.7670.99
333_H347_P0.7660.99
299_A373_F0.7650.99
298_T304_P0.7620.99
83_A87_L0.7610.99
285_H294_V0.7610.99
127_Q130_A0.7590.99
290_S327_G0.7590.99
242_I352_A0.7580.99
287_P420_N0.7580.99
268_G369_R0.7570.99
226_R254_F0.7550.99
210_D216_G0.7550.99
405_D409_G0.7540.99
223_P230_R0.7540.99
79_E152_R0.7540.99
156_V188_A0.7510.99
156_V160_F0.7510.99
378_E383_L0.7500.99
171_L352_A0.7490.99
270_L354_L0.7490.99
86_H151_L0.7480.99
186_V345_M0.7480.99
390_I423_T0.7470.99
163_I349_L0.7460.99
291_W435_E0.7420.99
251_C344_G0.7400.99
254_F260_F0.7400.99
84_T91_G0.7380.99
270_L350_L0.7360.99
362_L366_V0.7330.99
118_S123_L0.7310.99
164_N168_L0.7290.99
414_F417_W0.7290.99
59_A69_V0.7280.99
175_I186_V0.7280.99
284_I317_R0.7280.99
10_Y286_D0.7270.99
332_H342_D0.7260.99
376_S443_M0.7260.99
394_E397_F0.7260.99
57_A60_K0.7250.99
261_I362_L0.7230.99
135_F138_V0.7230.99
44_G72_I0.7230.99
198_A202_L0.7220.99
315_K334_Y0.7220.99
228_D232_A0.7210.99
379_I382_K0.7190.99
293_T327_G0.7190.99
417_W436_S0.7180.99
298_T303_T0.7150.99
150_N154_A0.7150.99
436_S441_P0.7140.99
179_N218_P0.7140.99
174_V241_G0.7130.99
202_L207_N0.7130.99
370_M376_S0.7090.99
205_V231_N0.7080.99
63_Q144_G0.7080.99
419_F449_T0.7060.99
32_Y36_L0.7020.99
153_D156_V0.6990.99
99_H108_K0.6990.99
72_I79_E0.6970.99
240_M253_L0.6940.99
397_F401_A0.6920.99
9_A425_N0.6890.99
416_D437_R0.6890.99
36_L91_G0.6870.99
380_N383_L0.6830.99
184_P188_A0.6820.99
230_R254_F0.6820.99
27_R130_A0.6790.99
241_G254_F0.6760.99
51_S55_K0.6760.99
42_V87_L0.6730.99
17_G53_T0.6710.99
366_V370_M0.6700.99
390_I398_S0.6700.99
186_V193_F0.6690.99
278_N324_I0.6690.99
385_Q388_E0.6690.99
179_N215_N0.6680.99
251_C348_W0.6670.99
102_M212_N0.6640.99
267_V325_Y0.6640.99
367_R371_A0.6630.99
8_K11_D0.6590.98
152_R156_V0.6570.98
265_Y372_A0.6550.98
411_S420_N0.6540.98
171_L356_C0.6530.98
275_L297_V0.6530.98
272_E372_A0.6510.98
413_T444_E0.6500.98
257_K367_R0.6470.98
29_G93_I0.6470.98
115_R319_R0.6440.98
445_A448_R0.6430.98
318_M336_R0.6420.98
126_V130_A0.6420.98
203_I232_A0.6410.98
409_G412_M0.6410.98
72_I80_I0.6410.98
109_L126_V0.6410.98
155_Y159_L0.6410.98
26_W61_G0.6400.98
271_A293_T0.6390.98
293_T304_P0.6390.98
443_M446_R0.6370.98
21_N24_I0.6360.98
172_K238_A0.6340.98
32_Y41_I0.6340.98
97_A100_N0.6340.98
270_L347_P0.6330.98
261_I269_L0.6320.98
390_I396_H0.6310.98
325_Y335_F0.6300.98
18_E103_D0.6290.98
116_P123_L0.6280.98
53_T57_A0.6270.98
380_N384_A0.6260.98
49_L102_M0.6250.98
75_S152_R0.6250.98
164_N357_L0.6250.98
81_Y340_Y0.6250.98
15_K19_E0.6240.98
275_L279_P0.6230.98
271_A325_Y0.6210.98
17_G21_N0.6200.98
381_S386_P0.6190.98
396_H399_R0.6180.98
113_G319_R0.6180.98
179_N216_G0.6170.98
389_A393_V0.6160.98
288_R309_T0.6150.98
376_S379_I0.6140.98
25_A57_A0.6130.98
28_I109_L0.6130.98
291_W413_T0.6120.98
100_N426_T0.6110.98
27_R30_R0.6100.98
177_S202_L0.6100.98
232_A238_A0.6100.98
410_I413_T0.6090.97
41_I67_V0.6080.97
60_K144_G0.6070.97
144_G148_Q0.6060.97
60_K63_Q0.6030.97
284_I307_S0.6000.97
63_Q143_R0.6000.97
186_V348_W0.6000.97
20_L24_I0.5970.97
393_V397_F0.5960.97
162_Y346_I0.5960.97
189_I345_M0.5940.97
277_K280_G0.5940.97
270_L351_V0.5930.97
305_V323_A0.5930.97
24_I130_A0.5910.97
441_P448_R0.5890.97
34_E132_A0.5890.97
239_D256_E0.5870.97
40_T87_L0.5870.97
25_A29_G0.5860.97
98_S108_K0.5860.97
440_V443_M0.5850.97
39_K112_E0.5850.97
358_K365_L0.5840.97
87_L149_I0.5830.97
285_H291_W0.5820.97
437_R441_P0.5820.97
416_D441_P0.5810.97
187_D204_K0.5810.97
170_P356_C0.5790.97
368_D371_A0.5780.97
418_R435_E0.5780.97
407_T421_L0.5750.96
10_Y116_P0.5740.96
370_M375_A0.5730.96
445_A449_T0.5720.96
390_I401_A0.5710.96
52_E73_G0.5710.96
285_H293_T0.5700.96
434_V442_L0.5700.96
393_V396_H0.5680.96
27_R131_E0.5670.96
261_I366_V0.5660.96
79_E185_V0.5650.96
71_D146_Y0.5630.96
409_G448_R0.5630.96
358_K361_T0.5630.96
100_N104_Y0.5620.96
120_D124_R0.5610.96
8_K425_N0.5610.96
86_H157_D0.5600.96
442_L445_A0.5600.96
215_N228_D0.5590.96
268_G272_E0.5570.96
193_F196_L0.5540.96
284_I314_I0.5540.96
380_N386_P0.5530.96
291_W295_D0.5530.96
201_E204_K0.5520.96
383_L389_A0.5510.95
210_D214_P0.5490.95
123_L126_V0.5490.95
226_R260_F0.5490.95
169_T239_D0.5460.95
176_N243_A0.5450.95
25_A58_L0.5450.95
201_E205_V0.5450.95
266_I331_A0.5440.95
355_V358_K0.5440.95
379_I446_R0.5440.95
6_C24_I0.5430.95
20_L25_A0.5420.95
193_F197_G0.5410.95
35_F126_V0.5410.95
262_E265_Y0.5410.95
275_L281_A0.5410.95
155_Y343_S0.5400.95
193_F244_F0.5400.95
84_T89_V0.5390.95
311_H342_D0.5370.95
209_P213_F0.5360.95
20_L28_I0.5300.94
136_P139_D0.5300.94
168_L353_E0.5290.94
75_S80_I0.5290.94
203_I238_A0.5280.94
243_A254_F0.5280.94
13_R99_H0.5270.94
61_G65_A0.5260.94
26_W30_R0.5250.94
58_L107_M0.5250.94
421_L432_L0.5240.94
174_V229_T0.5230.94
14_G19_E0.5220.94
201_E232_A0.5220.94
24_I27_R0.5220.94
111_R115_R0.5210.94
144_G147_Q0.5200.94
100_N108_K0.5200.94
22_E60_K0.5190.94
7_F28_I0.5180.94
423_T430_V0.5170.94
60_K143_R0.5170.94
170_P198_A0.5150.94
226_R241_G0.5140.94
98_S249_D0.5140.94
233_V258_G0.5130.93
63_Q69_V0.5130.93
226_R230_R0.5120.93
335_F346_I0.5110.93
219_N342_D0.5100.93
98_S328_E0.5100.93
139_D143_R0.5100.93
274_F324_I0.5080.93
251_C351_V0.5070.93
272_E358_K0.5070.93
194_K197_G0.5070.93
250_R328_E0.5070.93
16_L20_L0.5060.93
288_R433_N0.5060.93
379_I434_V0.5060.93
135_F139_D0.5050.93
351_V354_L0.5040.93
293_T297_V0.5040.93
16_L54_L0.5040.93
335_F347_P0.5040.93
273_A358_K0.5030.93
379_I385_Q0.5020.93
251_C333_H0.5020.93
42_V92_G0.5020.93
99_H249_D0.5010.93
115_R315_K0.5000.93
155_Y344_G0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2f7lA 4 0.9803 100 0.086 Contact Map
1wqaA 3 0.9781 100 0.087 Contact Map
1tuoA 1 0.9254 100 0.11 Contact Map
3uw2A 1 0.9539 100 0.123 Contact Map
3pdkA 2 0.9496 100 0.127 Contact Map
1p5dX 1 0.9693 100 0.132 Contact Map
3i3wA 2 0.9408 100 0.147 Contact Map
3na5A 2 0.9803 100 0.162 Contact Map
4hjhA 2 0.9496 100 0.166 Contact Map
2z0fA 2 0.9364 100 0.17 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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